HK1244285B - 作为制备类固醇FXR调节剂的中间体的5β-6-烷基-7-羟基-3-酮类固醇 - Google Patents
作为制备类固醇FXR调节剂的中间体的5β-6-烷基-7-羟基-3-酮类固醇 Download PDFInfo
- Publication number
- HK1244285B HK1244285B HK18103791.5A HK18103791A HK1244285B HK 1244285 B HK1244285 B HK 1244285B HK 18103791 A HK18103791 A HK 18103791A HK 1244285 B HK1244285 B HK 1244285B
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- HK
- Hong Kong
- Prior art keywords
- general formula
- compound
- alkyl
- halo
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1420593.4A GB201420593D0 (en) | 2014-11-19 | 2014-11-19 | Compounds |
| GBGB1420594.2A GB201420594D0 (en) | 2014-11-19 | 2014-11-19 | Compounds |
| GB1420593.4 | 2014-11-19 | ||
| GB1420594.2 | 2014-11-19 | ||
| GBGB1505674.0A GB201505674D0 (en) | 2015-04-01 | 2015-04-01 | Compounds |
| GB1505674.0 | 2015-04-01 | ||
| PCT/GB2015/053517 WO2016079518A1 (en) | 2014-11-19 | 2015-11-19 | 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HK1244285A1 HK1244285A1 (zh) | 2018-08-03 |
| HK1244285B true HK1244285B (zh) | 2020-06-05 |
Family
ID=54704020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18103791.5A HK1244285B (zh) | 2014-11-19 | 2015-11-19 | 作为制备类固醇FXR调节剂的中间体的5β-6-烷基-7-羟基-3-酮类固醇 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10131688B2 (zh) |
| EP (1) | EP3221332B1 (zh) |
| JP (1) | JP6724004B2 (zh) |
| KR (1) | KR102526632B1 (zh) |
| CN (1) | CN107108687B (zh) |
| CA (1) | CA2968301C (zh) |
| DK (1) | DK3221332T3 (zh) |
| EA (1) | EA033445B1 (zh) |
| ES (1) | ES2733643T3 (zh) |
| HK (1) | HK1244285B (zh) |
| MX (1) | MX375864B (zh) |
| PL (1) | PL3221332T3 (zh) |
| TW (1) | TWI686400B (zh) |
| WO (1) | WO2016079518A1 (zh) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107108688B (zh) | 2014-11-19 | 2019-10-29 | Nzp英国有限公司 | 作为制备类固醇FXR调节剂的中间体的6α-烷基-3,7-二酮类固醇 |
| US20170327531A1 (en) | 2014-11-19 | 2017-11-16 | NZP UK Limited | 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators |
| CN107207559B (zh) | 2014-11-19 | 2019-10-25 | Nzp英国有限公司 | 作为制备类固醇fxr调节剂的中间体的6-烷基-7-羟基-4-烯-3-酮类固醇 |
| JP2018538331A (ja) * | 2015-12-22 | 2018-12-27 | インターセプト ファーマシューティカルズ， インコーポレイテッド | オベチコール酸の多型結晶形態 |
| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| GB201608776D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
| GB201608779D0 (en) * | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
| CN106279331B (zh) * | 2016-07-27 | 2019-06-14 | 宋火良 | 胆酸类肝病治疗药物 |
| EP3431486A1 (en) | 2017-07-18 | 2019-01-23 | Bionice, S.L.U. | Process and intermediates for the synthesis of obeticholic acid and derivatives thereof |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| CN111138509B (zh) * | 2018-11-02 | 2022-12-06 | 东莞东阳光药物研发有限公司 | 奥贝胆酸的制备方法 |
| CN113135970B (zh) * | 2020-01-20 | 2024-11-22 | 成都贝诺科成生物科技有限公司 | 一种具有抗芽孢活性的化合物及其药用组合物 |
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| US4289872A (en) | 1979-04-06 | 1981-09-15 | Allied Corporation | Macromolecular highly branched homogeneous compound based on lysine units |
| US5229490A (en) | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
| CA2118130A1 (en) | 1992-04-14 | 1993-10-28 | Jean M. J. Frechet | Dendritic based macromolecules and method of production |
| AU6392894A (en) | 1993-02-26 | 1994-09-14 | Magainin Pharmaceuticals, Inc. | Chemical synthesis of squalamine |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US7138390B2 (en) | 2001-03-12 | 2006-11-21 | Intercept Pharmaceuticals | Steroids as agonists for FXR |
| US20090062256A1 (en) | 2001-06-01 | 2009-03-05 | Bristol-Myers Squibb Pharma Company | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION |
| AU2002352524B2 (en) | 2001-11-07 | 2007-10-04 | Nektar Therapeutics | Branched polymers and their conjugates |
| EP1568706A1 (en) | 2004-02-26 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Novel steroid agonist for FXR |
| ITMI20050912A1 (it) * | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
| JP2007210888A (ja) * | 2006-01-12 | 2007-08-23 | Mitsubishi Chemicals Corp | ステロイド化合物の製造方法 |
| CN101395170A (zh) | 2006-02-14 | 2009-03-25 | 英特塞普特药品公司 | 用于预防或治疗fxr介导的疾病或状态的作为fxr配体的胆汁酸衍生物 |
| WO2008002573A2 (en) | 2006-06-27 | 2008-01-03 | Intercept Pharmaceuticals, Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions |
| EP2112995B1 (en) | 2007-01-19 | 2013-07-31 | Intercept Pharmaceuticals, Inc. | 23-substituted bile acids as tgr5 modulators and methods of use thereof |
| CN105037476B (zh) * | 2008-07-30 | 2018-06-12 | 英特塞普特医药品公司 | Tgr5调节剂及其使用方法 |
| ES2592452T3 (es) | 2008-11-19 | 2016-11-30 | Intercept Pharmaceuticals, Inc. | Moduladores de TGR5 y métodos de uso de los mismos |
| EP2376519B1 (en) | 2008-11-19 | 2013-11-13 | Intercept Pharmaceuticals, Inc. | Tgr5 modulators and method of use thereof |
| US8829213B2 (en) | 2009-07-29 | 2014-09-09 | The University Of Chicago | Liver X receptor agonists |
| SG11201408501UA (en) | 2012-06-19 | 2015-01-29 | Intercept Pharmaceuticals Inc | Preparation, uses and solid forms of obeticholic acid |
| AU2013334122B2 (en) | 2012-10-26 | 2017-11-02 | Intercept Pharmaceuticals, Inc. | Process for preparing bile acid derivatives |
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| US20140206657A1 (en) * | 2013-01-18 | 2014-07-24 | City Of Hope | Bile acid analog tgr5 agonists |
| PT2997035T (pt) | 2013-05-14 | 2018-07-18 | Intercept Pharmaceuticals Inc | Derivados de 11-hidroxilo substituídos em 6 de ácidos biliares e seus conjugados de aminoácido como moduladores do recetor farnesoide x |
| HK1223361A1 (zh) | 2013-05-24 | 2017-07-28 | Société des Produits Nestlé S.A. | 用於预测肠易激综合征诊断的途径特异性测定 |
| WO2015183794A1 (en) | 2014-05-27 | 2015-12-03 | City Of Hope | Tgr5 agonist complexes for treating diabetes and cancer |
| CN106661079B (zh) | 2014-05-29 | 2019-03-01 | 巴尔制药有限公司 | 用于治疗和/或预防fxr和tgr5/gpbar1介导的疾病的胆烷衍生物 |
| KR20170094184A (ko) | 2014-11-06 | 2017-08-17 | 이난타 파마슈티칼스, 인코포레이티드 | Fxr/tgr5 작용제로서의 담즙산 유사체 및 이의 이용 방법 |
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| CN107108688B (zh) | 2014-11-19 | 2019-10-29 | Nzp英国有限公司 | 作为制备类固醇FXR调节剂的中间体的6α-烷基-3,7-二酮类固醇 |
| US20170327531A1 (en) | 2014-11-19 | 2017-11-16 | NZP UK Limited | 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators |
| CN107207559B (zh) | 2014-11-19 | 2019-10-25 | Nzp英国有限公司 | 作为制备类固醇fxr调节剂的中间体的6-烷基-7-羟基-4-烯-3-酮类固醇 |
| WO2016086134A1 (en) | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
| KR20170099909A (ko) | 2014-11-26 | 2017-09-01 | 이난타 파마슈티칼스, 인코포레이티드 | Fxr/tgr5 작용제로서의 담즙산 유사체 및 이의 이용 방법 |
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| CN106279328A (zh) | 2015-05-20 | 2017-01-04 | 重庆药友制药有限责任公司 | 一种制备6α-烷基鹅去氧胆酸的方法 |
| CN107771180B (zh) | 2015-06-19 | 2021-03-23 | 英特塞普特医药品公司 | Tgr5调节剂及其使用方法 |
| CN106397522A (zh) | 2015-07-31 | 2017-02-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 3,7‑二（叔丁基二甲基硅基氧基）‑6‑烯‑5β‑胆烷‑24‑酸甲酯 |
| CN106478759A (zh) | 2015-08-31 | 2017-03-08 | 陕西合成药业股份有限公司 | 奥贝胆酸衍生物及其制备方法和用途 |
| CN106478756A (zh) | 2015-09-02 | 2017-03-08 | 中美华世通生物医药科技（武汉）有限公司 | Oca-e单晶及其制备方法和用途 |
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-
2015
- 2015-11-19 PL PL15800910T patent/PL3221332T3/pl unknown
- 2015-11-19 HK HK18103791.5A patent/HK1244285B/zh unknown
- 2015-11-19 US US15/528,220 patent/US10131688B2/en active Active
- 2015-11-19 EP EP15800910.0A patent/EP3221332B1/en active Active
- 2015-11-19 CN CN201580062893.5A patent/CN107108687B/zh active Active
- 2015-11-19 MX MX2017006564A patent/MX375864B/es active IP Right Grant
- 2015-11-19 WO PCT/GB2015/053517 patent/WO2016079518A1/en not_active Ceased
- 2015-11-19 ES ES15800910T patent/ES2733643T3/es active Active
- 2015-11-19 DK DK15800910.0T patent/DK3221332T3/da active
- 2015-11-19 EA EA201790881A patent/EA033445B1/ru unknown
- 2015-11-19 CA CA2968301A patent/CA2968301C/en active Active
- 2015-11-19 TW TW104138184A patent/TWI686400B/zh not_active IP Right Cessation
- 2015-11-19 KR KR1020177016856A patent/KR102526632B1/ko active Active
- 2015-11-19 JP JP2017527816A patent/JP6724004B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN107108687A (zh) | 2017-08-29 |
| JP6724004B2 (ja) | 2020-07-15 |
| TW201629081A (zh) | 2016-08-16 |
| WO2016079518A1 (en) | 2016-05-26 |
| JP2017538691A (ja) | 2017-12-28 |
| US10131688B2 (en) | 2018-11-20 |
| MX375864B (es) | 2025-03-07 |
| KR20170099895A (ko) | 2017-09-01 |
| CA2968301A1 (en) | 2016-05-26 |
| EA201790881A8 (ru) | 2019-07-31 |
| TWI686400B (zh) | 2020-03-01 |
| EA033445B1 (ru) | 2019-10-31 |
| EA201790881A1 (ru) | 2017-11-30 |
| MX2017006564A (es) | 2018-01-26 |
| KR102526632B1 (ko) | 2023-04-27 |
| US20170320907A1 (en) | 2017-11-09 |
| PL3221332T3 (pl) | 2019-10-31 |
| DK3221332T3 (da) | 2019-07-29 |
| CN107108687B (zh) | 2019-10-29 |
| EP3221332B1 (en) | 2019-04-24 |
| EP3221332A1 (en) | 2017-09-27 |
| CA2968301C (en) | 2023-05-16 |
| ES2733643T3 (es) | 2019-12-02 |
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