HK1134033B - Eyelid scrub composition - Google Patents

Abstract

An eyelid scrub composition comprising polyhexamethylene biguanide (PHMB), 1,2-hexanediol, 1,2-octanediol, and a pH stabilizing surfactant solution present in an amount effective to control the pH level of the composition between 5.5 and 7.5. The composition can further comprise moisturizers and foam stabilizers. The composition can be combined with a fabric pad for use as an eyelid scrub, where the fabric pad is pre-moistened with the composition and packaged for use. The composition may be applied to the eyelid scrub and rubbed to induce foaming. The composition is produced by preparing a modified Ringer's solution and adding 1,2-hexanediol, 1,2-octanediol, and an effective amount of one or more pH stabilizing surfactants. The mixture is then heated and allowed to cool before polyhexamethylene biguanide is added.

Description

Eyelid scrub composition

Technical Field

The present invention relates to an antimicrobial composition. The present invention also relates to compositions useful as eyelid scrubs.

Background

Eyelids are important for the health of the entire eye because they protect the eye from hazards such as near objects, or airborne contaminants such as pollen, dust particles, or other foreign objects. The eyelids contain several glands, including the lacrimal and meibomian glands, which produce layers of tear film that are critical to eye health. When a person blinks, a new tear film is created and tears are distributed throughout the cornea to wet the surface of the eye. This blinking action also "flushes" foreign material out of the eye.

However, the eyelids also suffer from certain problems, which, although common, are somewhat annoying, especially for contact lens wearers, and may lead to other, more serious complications. One complication is blepharitis (blepharitis) caused by staphylococci. Blepharitis is a common chronic inflammation of the eyelids characterized by a scaly crust at the eyelid margin. This condition may be caused by a bacterial infection, or may be a primary allergy or associated with seborrhea on the face or scalp. Treatment typically involves periodic cleansing of the eyelid to remove excess grease, debris, and sloughed off skin that may cause problems.

Often associated with or secondary to blepharitis is an infection of the skin surface at the edge of the eyelid, known as an internal hordeolum. Other such infections include external hordeolum, commonly known as hordeolum, which is an infection of the tiny oil secreting meibomian glands surrounding the eyelashes along the eyelid margin. Hordeolum begins with a red, soft mass and usually develops completely within three days. Such conditions are accompanied by pain, redness and tenderness of the eyelid margin. Although meibomitis often recurs, periodic cleaning of the eyelid margin can minimize the occurrence of such conditions. The second problem is chalazion, which is an inflammation of the meibomian glands in the eyelid. Chalazions generally develop slowly over 2 to 3 weeks and, although they usually do not cause pain, they often require surgery if left untreated.

For any of the above problems, as well as other medical complications such as rosacea and seborrhea, proper eyelid hygiene with eyelid cleansers can minimize the severity of the onset of the problem, or can completely prevent the problem from occurring if taken early. Eyelid cleansers may be used to cleanse the eyelashes, eyelids, or periocular areas as well as may be used as a pre-surgical scrub to help reduce the presence of harmful bacteria that may cause infection, inflammation, or even endophthalmitis in a patient.

Endophthalmitis is an intraocular infection that usually occurs after cataract surgery. The causative agent of postoperative endophthalmitis is typically a bacterium, usually staphylococcus epidermidis. To prevent endophthalmitis and blepharitis after surgery, eyelid scrubs are commonly used to cleanse the eyelids.

Pure skin cleansers are often not suitable for use on the eyelids. Eyelid cleansers must be non-irritating to the sensitive skin surrounding the eye and the eye tissue itself, yet have an antimicrobial effect. One factor that causes eye irritation is abnormal pH of the eyelid cleansing composition. The non-irritating formulation should have a pH level close to neutral 7.0. Many skin cleansers have a pH outside this range. In order to control the pH level of skin cleansers, conventional pH adjusters are often employed. Conventional pH adjusters include: basic pH adjusters such as ammonia, monoalkylamines, dialkylamines and trialkylamines, monoalkanolamines, dialkanolamines and trialkanolamines, hydroxides of alkali metals and alkaline earth metals (e.g., ammonia, sodium hydroxide, potassium hydroxide, lithium hydroxide, monoethanolamine, triethylamine, isopropylamine, diethanolamine and triethanolamine), and acidic pH adjusters such as inorganic acids and polycarboxylic acids (e.g., hydrochloric acid, nitric acid, phosphoric acid, sulfuric acid, citric acid, glycolic acid and lactic acid). Unfortunately, the pH adjusting agent itself can also irritate the eye. Thus, there is a need for an eyelid scrub composition that is effective in killing bacteria but does not contain traditional pH adjusters so that it is gentle enough to be used around the eyes.

Disclosure of Invention

The compositions of the present invention are effective antimicrobial and provide minimal eye irritation. The composition contains polyhexamethylene biguanide (PHMB), 1, 2-hexanediol, 1, 2-octanediol, and a pH stabilizing surfactant solution present in an amount effective to control the pH level of the composition between 5.5 and 7.5. The use of surfactant solutions to control the pH, rather than traditional pH adjusters, makes the composition less irritating to the eye. Furthermore, the foaming ability of the surfactant solution contained in the composition improves its cleaning ability.

In one embodiment, the pH stabilizing surfactant solution contains disodium cocoamphodiacetate, polyoxyethylene (80) sorbitan monolaurate, decyl polyglucoside, and modified Ringer's solution.

In another embodiment, the composition further comprises a humectant such as methyl gluceth-20, sorbitol, glycerin, ethylene glycol, propylene glycol, a carboxylate, an amino acid, a glycoside derivative, urea, a lactate salt, and a pantothenic acid derivative.

The preparation of the composition: a modified ringer's solution is prepared by mixing an electrolyte in water, and 1, 2-hexanediol, 1, 2-octanediol, and an effective amount of one or more pH stabilizing actives are mixed with the modified ringer's solution. The mixture was then heated and allowed to cool before the polyhexamethylene biguanide was added.

The composition may be applied to the eyelid by applying an effective amount of the composition to the eyelid. Alternatively, the composition may be rubbed on the eyelid to produce foam.

The composition can be used as an eyelid scrub in combination with a fabric pad. The fabric pad is pre-wetted with the composition and packaged for use. Description of the drawings figure 1 is a top view of the fabric pad of the present invention. Fig. 2 is a top view of the fabric pad container.

Detailed Description

The composition of the present invention is effective as an eyelid cleanser or scrub because it has antibacterial efficacy but remains practically non-irritating to the eye. The composition has these beneficial properties due to the combination of polyhexamethylene biguanide (PHMB) and Symdiol. Symdiol is a combination of 1, 2-hexanediol and 1, 2-octanediol. The PHMB-Symdiol combination has a synergistic antibacterial effect. In addition, the compositions of the present invention avoid the traditional pH adjusters by using a pH stabilizing surfactant solution. The removal of conventional pH adjusters reduces the degree of irritation caused by the composition compared to previous eyelid cleansers.

The eyelid scrub composition of the present invention contains polyhexamethylene biguanide (PHMB), 1, 2-hexanediol, 1, 2-octanediol, and a pH stabilizing surfactant solution present in an amount effective to control the pH level of the composition between 5.5 and 7.5.

For the purposes of the present invention, polyhexamethylene biguanide (PHMB) is the pseudonym of polyhexamethylene biguanide, polyhexamethylene biguanide hydrochloride and polyaminopropyl biguanide. A20% aqueous solution of PHMB under the trade name of Arch Personal Care Products L.PAnd (5) selling the product. The combination of 1, 2-hexanediol and 1, 2-octanediol is sold by Symrise under the trade name Symdiol 68. 1, 2-octanediol is also known as octanediol. PHMB has synergistic antimicrobial efficacy in combination with 1, 2-hexanediol and 1, 2-octanediol.

To avoid the irritating effects of conventional pH adjusting agents, pH stabilizing surfactant solutions are prepared to provide a pH stable composition. The surfactant may also enhance the cleaning ability of the composition and have foaming ability. PHMB is most effective as an antibacterial agent in the pH range of 5.5 to 7.5. Therefore, it is necessary to control the pH level of the composition within this range by mixing a surfactant. There is also a need for the eyelid scrub of the present invention to have foaming capabilities that promote physical cleansing of the eyelid. Therefore, a surface cleaner must be selected that can both control the pH of the composition within the effective range of PHMB and provide the foaming capacity necessary to physically clean the eyelids.

Advantageously, controlling the pH of the composition with a surfactant solution rather than a traditional pH adjusting agent has the benefit of safety, as many traditional pH adjusting agents are irritating to the eye. Generally, surfactants are less irritating to the eye than traditional pH adjusters. Examples of conventional pH adjusters include: basic pH adjusters such as ammonia, monoalkylamines, dialkylamines and trialkylamines, monoalkanolamines, dialkanolamines and trialkanolamines, hydroxides of alkali metals and alkaline earth metals (e.g., ammonia, sodium hydroxide, potassium hydroxide, lithium hydroxide, monoethanolamine, triethylamine, isopropylamine, diethanolamine and triethanolamine), and acidic pH adjusters such as inorganic acids and polycarboxylic acids (e.g., hydrochloric acid, nitric acid, phosphoric acid, sulfuric acid, citric acid, glycolic acid and lactic acid).

In addition to reducing irritation, many surfactants have the added ability to generate foam, which can aid the cleaning ability of the composition. To form the pH stabilizing surfactant solution, one or more foam-generating surfactants are first selected to provide the foaming capabilities of the composition. Suitable surfactants include anionic, nonionic and amphoteric surfactants. In one embodiment, polyoxyethylene (80) sorbitan monolaurate and decyl polyglucoside are both used as the lathering surfactant.

To control the pH of the composition, one or more additional surfactants may be required in the pH stabilizing surfactant solution to compensate for the pH level of the foaming surfactant. To determine whether a pH compensating surfactant is required, the pH of the foaming surfactant is measured and the pH compensating surfactant is selected to control the pH of the solution within the desired range. For example, if the pH level of the foaming surfactant is in the acidic range, i.e., below 7.0, a pH compensating surfactant in the alkaline range is selected. Suitable pH compensating surfactants include foaming and non-foaming surfactants, which also include anionic, nonionic and amphoteric surfactants. In one embodiment, the pH compensating surfactant is disodium cocoamphodiacetate.

The surfactant composition is added to the modified ringer's solution. For the purposes of the present invention, a modified ringer's solution is an isotonic aqueous solution of electrolytes that is physiologically compatible with human tissue. In one embodiment, the modified ringer's solution comprises sodium chloride, potassium chloride, calcium chloride, and water. The surfactant solution contains a modified ringer's solution to ensure that the composition does not remove water from human tissue by osmosis.

The combination of surfactant and modified ringer's solution is mixed with the combination of PHMB, 1, 2-hexanediol, and 1, 2-octanediol to form an eyelid scrub composition. To determine the correct amount of each surfactant included in the eyelid scrub composition, the pH of the entire composition, the foaming capacity of the composition, and the cleansing capacity of the composition were tested. The pH level of the composition is measured with a pH meter and the amount of each surfactant is adjusted to control the pH of the composition within the desired pH range.

The foaming capacity of the compositions was measured according to the Ross Miles method. The measurements include generating foam from the composition and measuring foam height and stability over time. The foam was generated by pouring the composition from a set height into itself for five minutes. Alternatively, if the composition has a low foaming capacity, the composition may be stirred with a turbine stirrer for a certain period of time to produce foam. The foam thickness was measured at regular time intervals. The amount of foaming surfactant in the composition is varied to achieve the desired foaming capacity.

Finally, the cleaning ability of the composition was tested by a random human test. The composition is applied to the eyes by a human for cleansing the eyelids. The level of irritation, skin tone and overall clean feel caused by the composition are reported by humans. The amount and type of surfactant used is adjusted according to these reports.

The effective amount of the pH stabilizing surfactant to be used is determined by adjusting the amount and type of the surfactant in the pH stabilizing surfactant solution according to the test results of pH level, foaming ability and cleaning ability. The combination of the pH stabilizing surfactant solution with PHMB, 1, 2-hexanediol, and 1, 2-octanediol forms the composition of the present invention.

In a first embodiment, the composition of the invention contains PHMB, 1, 2-hexanediol, and 1, 2-octanediol in combination with a pH stabilizing surfactant solution. Suitable surfactants that can be used in the pH stabilized surfactant solution include amphoteric surfactants, anionic surfactants, and nonionic surfactants. Suitable amphoteric surfactants include, but are not limited to, alkyl dimethyl betaines, alkyl amide betaines, sulfobetaines, and imidazoline amphoteric surfactants. Suitable anionic surfactants include, but are not limited to, fatty alcohol sulfates, alpha-olefin sulfonates, sulfosuccinates, sarcosinates, phosphate esters, and carboxylates. Suitable nonionic surfactants include, but are not limited to, alkanolamides, ethoxyamides, esters, alcohol alkoxylates (alkoxylated alcohols), alkylpolyglucosides, amine oxides, sorbitan esters, and ethoxylates.

In one embodiment, the pH stabilizing surfactant solution contains disodium cocoamphodiacetate, polyoxyethylene (80) sorbitan monolaurate, decyl polyglucoside, and a modified ringer's solution. Disodium cocoyl amphodiacetate is an amphoteric surfactant. Polyoxyethylene (80) sorbitan monolaurate and decyl polyglucoside are both nonionic surfactants. In another embodiment, when mixed, the composition contains about 0.1 to 25% by weight disodium cocoamphodiacetate, 0.1 to 10% by weight polyoxyethylene (80) sorbitan monolaurate, 0.2 to 10% by weight decyl polyglucoside, and 60 to 98% by weight modified ringer's solution.

In another embodiment of the invention, the modified ringer's solution comprises sodium chloride, potassium chloride, calcium chloride, and water. Preferably, the water used is purified water. The modified ringer's solution may further comprise 0.05 wt.% to 1.2 wt.% sodium chloride, 0.005 wt.% to 0.5 wt.% potassium chloride, 0.005 wt.% to 0.5 wt.% calcium chloride, and water. In yet another embodiment, the modified ringer's solution comprises about 0.7 wt% sodium chloride, about 0.03 wt% potassium chloride, about 0.033 wt% calcium chloride, and purified water.

In yet another embodiment, the compositions of the present invention may further comprise one or more humectants. Moisturizers are compounds that prevent the loss of moisture from the epidermis. Moisturizers prevent water loss by forming a film on the skin surface to prevent evaporation from the skin surface. Alternatively, moisturizers contain hygroscopic molecules that draw components from the air into the skin. Suitable humectants include, but are not limited to, methyl gluceth-20, sorbitol, glycerol, propylene glycol, carboxylates, amino acids, glycoside derivatives, urea, lactate, and pantothenic acid derivatives. Examples of pantothenic acid derivatives include panthenol, D-panthenol and D, L-panthenol.

In yet another embodiment, the composition further comprises a foam stabilizer. Foam stabilizers are chemicals that increase the life of the foam. The foam stabilizer may be a polyethylene glycol diester of methyl glucose and a fatty acid. Suitable fatty acids include oleic acid, stearic acid, lauric acid, caprylic acid and capric acid. Suitably, the foam stabiliser is PEG-120 methyl glucose dioleate.

In a specific embodiment, the composition contains polyhexamethylene biguanide, 1, 2-hexanediol, 1, 2-octanediol, D-panthenol, disodium cocoamphodiacetate, polyoxyethylene (80) sorbitan monolaurate, decyl polyglucoside, methyl gluceth-20, and PEG-120 methyl glucose dioleate. Decyl polyglucoside is sold under the trade name Oramix NS by Seppic, Inc. Polyoxyethylene (80) sorbitan monolaurate is sold by BASF Corporation under the trade name T-MAZ 28. Disodium cocoyl amphodiacetate is sold by The Mcintyre Group under The trade name Mackam 2C. Methyl glucitol polyether-20 is sold under the trade name DowAnd E-20. PEG-120 methyl glucose dioleate is sold by Dow under the trade name glucimate DOE-120. D-panthenol is also known as Dexpantenol and is available from Dow.

In another specific embodiment the composition contains from about 0.02% to about 0.3% by weight PHMB, from about 0.05% to about 2.0% by weight 1, 2-hexanediol, from about 0.05% to about 2.0% by weight 1, 2-octanediol, from about 0.1% to about 25% by weight disodium cocoamphodiacetate, from about 0.1% to about 10% by weight polyoxyethylene (80) sorbitan monolaurate, from about 0.2% to about 10% by weight decyl polyglucoside, and from about 60% to about 98% by weight modified ringer's solution.

In yet another specific embodiment the composition contains about 0.04% by weight polyhexamethylene biguanide, about 0.2% by weight 1, 2-hexanediol, about 0.2% by weight 1, 2-octanediol, about 0.2% by weight D-panthenol, about 0.215% by weight disodium cocoamphodiacetate, about 4.032% by weight polyoxyethylene (80) sorbitan monolaurate, about 0.275% by weight decyl polyglucoside, about 4.3% by weight methyl gluceth-20, about 0.6% by weight PEG-120 methyl glucose dioleate, about 87.985% by weight modified ringer's solution, and water.

Non-zinc

Zinc salts are astringent agents that cause skin tightening. The skin in the periocular region is more sensitive than the skin in other regions. Inclusion of a zinc salt in the composition may be undesirable as the astringent nature of the zinc salt will make the composition more irritating to the eyelid area. Thus, in one embodiment, the composition contains PHMB, 1, 2-hexanediol, 1, 2-octanediol, and a pH stabilizing surfactant solution, but is substantially free of zinc salts. Examples of zinc salts include zinc acetate, zinc lactate, zinc gluconate, zinc citrate, zinc butyrate, and zinc stearate.

Method of producing a composite material

To prepare the compositions of the present invention, a modified ringer's solution is prepared by mixing the electrolyte in water. Symdiol, a combination of 1, 2-hexanediol and 1, 2-octanediol, is mixed with a modified ringer's solution and a surfactant comprising a pH stabilizing surfactant solution. The mixture is then heated to dissolve the solid in the solution. The mixture was allowed to cool before the polyhexamethylene biguanide was added. In one aspect of the method, the mixture is heated to about 60 ℃. In another aspect, the mixture is allowed to cool until its temperature reaches about 40 ℃.

In another embodiment of the method of producing the composition, the modified ringer's solution is prepared by mixing sodium chloride, potassium chloride, calcium chloride, and water. In yet another embodiment, one or more humectants are also added to the modified ringer's solution. Foam stabilizers may also be included.

The compositions of the present invention are useful for cleansing the eyelid. The eyelid scrub can be used for preoperative sterilization of the eyelid and daily application for prevention of various eyelid diseases, such as blepharitis. To clean the eyelid, an effective amount of an eyelid scrub is applied to the eyelid. The eyelid scrub comprises polyhexamethylene biguanide, 1, 2-hexanediol, 1, 2-octanediol, and a pH stabilizing surfactant solution present in an amount effective to control the pH level of the composition between 5.5 and 7.5. The eyelid scrub may be rubbed on the eyelid to create a foam that facilitates cleansing the eyelid. Advantageously, the eyelid scrub of the present invention can be gentle enough that it can be left on the eyelid after cleansing without rinsing. The ability to retain the eyelid scrub on the eyelid without rinsing enhances the antimicrobial effect of the composition. The longer the antimicrobial composition is generally allowed to contact the pathogen, the more pathogen will be killed.

In another aspect of the method of using the composition of the present invention, the eyelid scrub is applied to the eyelid with a fabric pad. The eyelid scrub may be rubbed with a fabric pad on the eyelid to generate foam, which aids in the cleansing ability of the eyelid scrub.

Pre-wetting cushion

Referring now to fig. 1, the composition of the present invention may be used in conjunction with a fabric pad 1 to form a device for cleansing the eyelids. In a first embodiment, the device comprises a fabric pad 1 pre-moistened with an eyelid scrub composition. The eyelid scrub composition contains polyhexamethylene biguanide, 1, 2-hexanediol, 1, 2-octanediol, and a pH stabilizing surfactant solution present in an amount effective to control the pH level of the composition between 5.5 and 7.5. In one aspect, the fabric pad 1 comprises a rayon and polypropylene blend fabric. In another aspect, the fabric pad has a woven textured surface (textured surface) 2.

Referring now to fig. 2, in another embodiment, the apparatus further comprises a sealable container 3 in which the pre-moistened fabric pad is enclosed. In one aspect, the sealable container 3 may comprise a box or package. The package may be made of any suitable material, including plastic or metal foil materials. The pre-moistened woven mats may be individually packaged for use. In yet another embodiment, the device contains 1.3 grams to 1.5 grams of eyelid scrub. Preferably, 1.4 grams of eyelid scrub is used.

Test results

The compositions of the present invention have a lower irritation level of antimicrobial effect than other antimicrobial compositions. To confirm the properties of the compositions of the present invention, the compositions were tested for irritation and antimicrobial effect. These results are in combination with another commonly available composition,for comparison.

One embodiment of the composition of the present invention (hereinafter referred to as composition 1) was tested for its irritant and antibacterial effects. Composition 1 contains polyhexamethylene biguanide, 1, 2-hexanediol, 1, 2-octanediol, D-panthenol, disodium cocoamphodiacetate, polyoxyethylene (80) sorbitol monolaurate, decyl polyglucoside, methyl gluceth-20, PEG-120 methyl glucose dioleate, a modified ringer's solution, and water.

Commonly available eyelid swabs were also tested for comparison purposes-is obtainable from Advanced Vision and comprises water, PEG-80, sorbitan laurate, sodium trideceth sulfate, cocamidopropyl betaineSodium lauryl amphoacetate, PEG-150 distearate, sodium laureth-13-carboxylate, linalool, hydroxyethyl piperazine ethanesulfonic acid acetate (hepes acetate), sodium perborate monohydrate, panthenol, allantoin, sodium chloride, tea tree oil, Tris-EDTA, boric acid, cocamidopropyl PG-dimethylammonium chloride, etidronic acid, phosphonic acid, and for pH adjustment and citric acid and sodium hydroxide.

To determine the irritation level of the composition, an ocular irritation study was conducted and the results were scored according to the Draize Scale for ocular injury scoring. The irritation test was performed by applying 0.1ml of the composition to the conjunctival sac of a rabbit's eye and recording the size and intensity of the ocular irritation at 1, 24, 48 and 72 hours. This information is translated into a score on the Dreherg scale, which represents the stimulus caused by the composition.

Composition 1 andthe results of the irritation test are shown in Table 1. Composition 1 scored 1.67 of the possible 110.0 on the delaze scale. On the Dreherg scale, 1.67 is classified as "practically non-irritating".Scored 4.0 on the Drehem scale, which was classified as "mild irritation". TABLE 1Ocular irritation testDrehe's scoreComposition comprising a metal oxide and a metal oxide Mean stimulation scoreComposition 11.67/110.0 4.0/110.0

Composition 1 andtime-kill studies were conducted to determine their effectiveness against s.epidermidis, which is the causative agent of postoperative endophthalmitis (post-operative)One type of infection). The time-kill test involves adding a suspension of the pathogen to the composition for 60 seconds and then neutralizing the composition. The pathogens are then inoculated into the plate and incubated for an appropriate period of time. After incubation, the number of colonies of the pathogen was counted and the Log Reduction (Log Reduction) of the number of colonies from the number of control colonies was calculated. The results of the time-kill study are shown in table 2. TABLE 2Time-kill test for Staphylococcus epidermidis Composition comprising a metal oxide and a metal oxide Logarithmic reduction valueComposition 15.5 3.5

Composition 1 was found to have a staphylococcus epidermidis log reduction value of 5.5, while Sterilid was found to have a staphylococcus log reduction value of 3.5. Thus composition 1 has a higher ability to kill Staphylococcus epidermidis pathogens than Sterilid.

The results of these irritation and time-kill tests indicate that composition 1 is more effective and less irritating than Sterilid, which uses citric acid and sodium hydroxide as the pH modifier instead of the pH modifying surfactant solution of the present invention.

Although the present invention has been described with reference to several embodiments, workers skilled in the art will recognize that changes may be made in form and detail without departing from the spirit and scope of the invention. Furthermore, the composition is described for use as an eyelid cleanser. It should also be readily understood that the compositions of the present invention may also be used for other applications.

Claims (35)

1. A composition comprising:

polyhexamethylene biguanide;

1, 2-hexanediol;

1, 2-octanediol;

60 to 98 weight percent of a modified ringer's solution, wherein the modified ringer's solution comprises sodium chloride, potassium chloride, calcium chloride; and water, and

a pH stabilizing surfactant solution present in an amount effective to control the pH level of the composition between 5.5 and 7.5, said pH stabilizing surfactant solution comprising:

one or more amphoteric surfactants comprising: one or more pH compensating surfactants comprising from 0.1 wt% to 25 wt% disodium cocoamphodiacetate,

the pH stabilizing surfactant solution further comprises:

a mixture of one or more foam-generating surfactants comprising at least one of:

0.1-10% by weight of polyoxyethylene (80) sorbitan monolaurate; and

0.2 to 10% by weight of decyl polyglucoside,

wherein the type and amount of the pH compensating surfactant is determined based on the measured pH of the mixture of surfactants that produces foam.

2. The composition of claim 1, wherein the amphoteric surfactant is selected from the group consisting of: alkyl dimethyl betaines, alkyl amide betaines, sulfobetaines and imidazoline amphoteric surfactants.

3. The composition of claim 1, wherein the modified ringer's solution comprises:

0.05 to 1.2% by weight of sodium chloride;

0.005 to 0.5% by weight of potassium chloride;

0.005 to 0.5% by weight of calcium chloride; and

and (3) water.

4. The composition of claim 3, wherein the modified ringer's solution comprises:

0.7% by weight of sodium chloride;

0.03% by weight of potassium chloride;

0.033% by weight calcium chloride; and

purifying the water.

5. The composition of claim 1, further comprising:

d-panthenol;

methyl glucitol polyether-20; and

PEG-120 methyl glucose dioleate.

6. The composition of claim 1, further comprising one or more humectants.

7. The composition of claim 6, wherein the one or more humectants are selected from the group consisting of: methyl gluceth-20, sorbitol, glycerol, ethylene glycol, propylene glycol, carboxylic acid esters, amino acids, decyl polyglucoside, urea, lactate esters, and panthenol, D-panthenol, and D, L-panthenol and combinations thereof.

8. The composition of claim 1, further comprising a foam stabilizer.

9. The composition of claim 8 wherein the foam stabilizer is a polyethylene glycol diester of methyl glucose and a fatty acid.

10. The composition of claim 9, wherein the fatty acid is selected from the group consisting of oleic acid, stearic acid, lauric acid, caprylic acid, and capric acid.

11. A composition comprising:

polyhexamethylene biguanide;

1, 2-hexanediol;

1, 2-octanediol;

60 to 98 weight percent of a modified ringer's solution, wherein the modified ringer's solution comprises sodium chloride, potassium chloride, calcium chloride; and water, and

a pH stabilizing surfactant solution present in an amount effective to control the pH level of the composition between 5.5 and 7.5, said pH stabilizing surfactant solution comprising:

one or more amphoteric surfactants comprising: one or more pH compensating surfactants comprising from 0.1 wt% to 25 wt% disodium cocoamphodiacetate,

the pH stabilizing surfactant solution further comprises:

a mixture of one or more foam-generating surfactants comprising at least one of:

0.1 wt% to 10 wt% polyoxyethylene (80) sorbitan monolaurate; and

0.2 to 10% by weight of decyl polyglucoside,

wherein the type and amount of the pH compensating surfactant is determined based on a measured pH of a mixture of surfactants that produce foam,

wherein the composition is free of zinc salts.

12. The composition of claim 11, wherein the amphoteric surfactant is selected from the group consisting of: alkyl dimethyl betaines, alkyl amide betaines, sulfobetaines and imidazoline amphoteric surfactants.

13. The composition of claim 11, further comprising one or more humectants.

14. The composition of claim 13, wherein the one or more humectants are selected from the group consisting of: methyl gluceth-20, sorbitol, glycerol, ethylene glycol, propylene glycol, carboxylic acid esters, amino acids, decyl polyglucoside, urea, lactate, and panthenol, D-panthenol and D, L-panthenol, and combinations thereof.

15. The composition of claim 11, further comprising a foam stabilizer.

16. The composition of claim 15 wherein the foam stabilizer is a polyethylene glycol diester of methyl glucose and a fatty acid.

17. A composition comprising:

polyhexamethylene biguanide;

1, 2-hexanediol;

1, 2-octanediol;

0.1-25% by weight disodium cocoamphodiacetate;

0.1 wt% to 10 wt% polyoxyethylene (80) sorbitan monolaurate;

0.2 to 10 weight% decyl polyglucoside; and

60 to 98 weight percent of modified ringer's solution, wherein the modified ringer's solution comprises sodium chloride, potassium chloride, calcium chloride; and water.

18. The composition of claim 17, wherein the composition further comprises one or more humectants.

19. The composition of claim 18, wherein the humectant is selected from the group consisting of: methyl gluceth-20, sorbitol, glycerol, ethylene glycol, propylene glycol, carboxylates, amino acids, decyl polyglucoside, urea, lactates, and panthenol, D-panthenol and D, L-panthenol and combinations thereof.

20. The composition of claim 17, further comprising:

d-panthenol;

methyl glucitol polyether-20; and

PEG-120 methyl glucose dioleate.

21. A composition comprising:

polyhexamethylene biguanide;

1, 2-hexanediol;

1, 2-octanediol;

d-panthenol;

0.1-25% by weight disodium cocoamphodiacetate;

0.1 wt% to 10 wt% polyoxyethylene (80) sorbitan monolaurate;

0.2 to 10 weight% decyl polyglucoside;

methyl glucitol polyether-20; and

PEG-120 methyl glucose dioleate.

22. A composition comprising:

0.02 to 0.3% by weight of polyhexamethylene biguanide;

0.05 to 2.0% by weight of 1, 2-hexanediol;

0.05 to 2.0% by weight of 1, 2-octanediol;

0.1 to 25% by weight of disodium cocoamphodiacetate;

0.1 to 10% by weight of polyoxyethylene (80) sorbitan monolaurate;

0.2 to 10% by weight decyl polyglucoside; and

60 to 98 weight percent of a modified ringer's solution, wherein the modified ringer's solution comprises sodium chloride, potassium chloride, calcium chloride; and water.

23. The composition of claim 22, further comprising:

0.05 to 5.0% by weight of D-panthenol;

1.0 to 20% by weight of methyl gluceth-20; and

0.1 to 5% by weight of PEG-120 methyl glucose dioleate.

24. A composition comprising:

0.04% by weight of polyhexamethylene biguanide;

0.2% by weight of 1, 2-hexanediol;

0.2% by weight of 1, 2-octanediol;

0.2% by weight of D-panthenol;

0.215% by weight disodium cocoamphodiacetate;

4.032 wt% polyoxyethylene (80) sorbitan monolaurate;

0.275% by weight decyl polyglucoside;

4.3% by weight of methyl glucitol polyether-20;

0.6 wt% PEG-120 methyl glucose dioleate;

87.985 wt% of a modified ringer's solution, wherein the modified ringer's solution comprises sodium chloride, potassium chloride, calcium chloride; and water; and

1.953% by weight of water.

25. A method of preparing an eyelid scrub composition comprising the steps of:

a) preparing modified ringer's solution by mixing sodium chloride, potassium chloride, calcium chloride and water,

b) mixing 1, 2-hexanediol, 1, 2-octanediol, and an effective amount of one or more pH stabilizing surfactants selected from the group consisting of 0.1 wt% to 25 wt% disodium cocoamphodiacetate, 0.1 wt% to 10 wt% polyoxyethylene (80) sorbitan monolaurate, 0.2 wt% to 10 wt% decyl polyglucoside, and combinations thereof, with the modified ringer's solution;

c) heating the mixture;

d) cooling the mixture; and

e) polyhexamethylene biguanide was added to the cooled mixture.

26. The method of claim 25, wherein step b) further comprises mixing one or more humectants with the modified ringer's solution.

27. The method of claim 25, wherein step c) comprises heating the mixture to 60 ℃.

28. The method of claim 27, further comprising dissolving the solid prior to cooling the mixture.

29. The method of claim 25, wherein step d) comprises cooling the mixture to 40 ℃.

30. An eyelid scrub composition prepared according to the method of claim 25.

31. A device for cleansing the eyelid comprising: a fabric pad pre-moistened with an eyelid scrub composition, the eyelid scrub composition being a composition as defined in claim 23.

32. The device of claim 31, wherein said fabric pad comprises a rayon and polypropylene blend fabric.

33. The device of claim 31, wherein said fabric pad comprises a textile textured surface.

34. The device of claim 31, wherein the device further comprises a sealable container having a pre-moistened fabric pad disposed therein.

35. The device of claim 31, wherein the device contains from 1.3 grams to 1.5 grams of the eyelid scrub composition.