HK1131619B

HK1131619B - Stat3/5 activation inhibitor

Info

Publication number: HK1131619B
Application number: HK09111385.1A
Authority: HK
Inventors: 和生关口; 敬铃木; 丰大渕; 贡广奥野; 直人大井; 健司大西; 晶章本山; 宪司吉田; 健志儿玉; 和久杉山; 圣司赤松; 邦彦清野; 康夫柳原; 隆司渡边; 一彦林; 英男田中; 卓美住田
Original assignee: 大塚制药株式会社
Priority date: 2006-10-02
Filing date: 2007-10-02
Publication date: 2015-03-06

Description

STAT3/5 activation inhibitors

Technical Field

The invention relates to a STAT3/5 activation inhibitor.

Background

The STAT (signal transducer and activator of transcription) protein family is one of the DNA binding proteins and plays a role in information transmission and activation of transcription. Currently, the STAT family is known to have 6 different members (STAT1, STAT2, STAT3, STAT4, STAT5 and STAT6) and several subtypes (STAT1 α, STAT1 β, STAT3 α, STAT3 β, STAT5a and STAT5 b). STAT activity is regulated by stimulation of various cytokines and mitogens. When a cytokine binds to its receptor, it activates the Janus protein tyrosine kinase (JAK) associated with that receptor.

STAT3 has an SH2(src homology domain 2) domain that is capable of recognizing the structure of a specific phosphorylated tyrosine. STAT3 is believed to specifically recognize phosphorylated tyrosine in the gp130 cell domain and is transported to gp130 where tyrosine is phosphorylated by JAK. STAT3 having phosphorylated tyrosine forms either a dimer of STAT3 (homodimer) or a dimer of STAT3 and STAT1 (heterodimer) through its SH2 region, migrates into the nucleus, and recognizes and binds to a specific DNA sequence. By this pathway, STAT3 is known to regulate transcription of many genes.

This in vivo effect of STAT3/5 has been reported in several publications.

For example, non-patent document 1 describes the relationship between activation of STAT3 and the IL-6-signaling pathway and the relationship between IL-6 and chronic diseases such as Alzheimer's disease, rheumatism, Crohn's disease, and anemia, and cancer-related diseases such as cachexia.

Further, non-patent document 2 describes a relationship between STAT3 activation and hepatitis c virus, and non-patent document 3 describes a relationship between STAT3 activation and psoriasis, respectively. Also, non-patent document 2 describes the relationship between STAT3 and inflammatory diseases and autoimmune diseases, and non-patent document 4 describes the relationship between STAT3 activation and obesity, diabetes, infertility, and thermal disorder (thermal dysregulation), respectively. Non-patent documents 5 and 6 and the like describe that STAT5 is a key factor in IgE-induced MC (mast cell) activation and inflammatory and autoimmune diseases, and describe the role of STAT5 in allergy, inflammation, hyperprolactinemia (hyperprolactimia), and malignant tumor.

On the other hand, an aromatic compound having a collagen production inhibitory action (collagen production inhibition action) is known (patent document 1). However, the aromatic compound described in patent document 1 is not known to have a STAT3/5 activation inhibitory effect.

[ patent document 1] WO2006/014012

[ patent document 2] US2001/0029250

(non-patent document 1) j.gerntology; MEDICAL SCIENCES 2006, Vol.61A, No.6, 575-

[ non-patent document 2] J.Exp.Med.Vol.196, No.5, 2002, 641-653-

[ non-patent document 3] Nature Medicine, Vol.11, No.1, 2005, 43-49

[ non-patent document 4] PNAS March 30, 2004, vol.101, No.13, 4661-

[ non-patent document 5] J.immunology, 2006, 177: 3421-3426

[ non-patent document 6] Ann. Rheum. Dis.2004; 63: 67-71.

Disclosure of Invention

It is an object of the present invention to provide a STAT3/5 activation inhibitor.

The present inventors have repeatedly studied the aromatic compound described in patent document 1. As a result, the compound was found to have STAT3/5 activation inhibitory effect. The present invention has been achieved based on such a finding.

Accordingly, the present invention provides a STAT3/5 activation inhibitor represented by the following items A to C.

Item A: a STAT3/5 activation inhibitor comprising, as an active ingredient, an aromatic compound represented by the following general formula (hereinafter sometimes simply referred to as aromatic compound (1)) or a salt thereof:

[ general formula 1]

Wherein, X₁Represents a nitrogen atom or a group-CH ═ CH;

R¹represents a group-Z-R⁶，

Z represents a group-N (R)⁸) -B-, group-B-N (R)⁸) -, group-B₀-O-、

[ general formula 2]

A radical of (A), a radical-CO-, a radical-CH (OH) -, a radical-N (R)^9a)-CO-N-(R^9b) -, group-N ═ CH-, group-N (R)^10a)-SO₂-(B_22a) e-, lower alkenylene group, group-NHCO-B₁-, the radical-NHCO-B₂- (W) u-, group-B₀-O-B_19a-、

[ general formula 3]

A group of,

[ general formula 4]

Group of (a), group-SO₂-N(R^10b) -, a group-S-, a lower alkynylene group, a lower alkylene group, a group-N (R)^8d) -or a group-CO-NH-B_18a-，R⁸Represents a hydrogen atom, a lower alkyl group which may have a lower alkoxy group as a substituent, a lower alkanoyl group, a lower alkylsulfonyl group or a phenyl lower alkyl group,

b represents a group-CO-or a lower alkylene group,

B₀represents a lower alkylene group, and is represented by,

B₁represents a lower alkenylene group which may have a phenyl group as a substituent,

B₂represents a lower alkylene group which may be substituted by a group selected from a lower alkoxy group and a phenyl group,

R^9arepresents a hydrogen atom or a lower alkyl group,

R^9brepresents a hydrogen atom or a lower alkyl group,

R^10arepresents a hydrogen atom or a lower alkyl group,

B_22arepresents a lower alkylene group or a lower alkenylene group,

e represents a number of 0's or 1's,

B_18arepresents a lower alkylene group, and is represented by,

B_19aRepresents a lower alkylene group, and is represented by,

B_20arepresents a lower alkylene group, and is represented by,

B_21arepresents a lower alkylene group, and is represented by,

k represents a number of 2 or 3,

c represents a number of 0 or 1,

d' represents a number of 0 or 1,

R^10brepresents a hydrogen atom or a lower alkyl group,

R^8drepresents a hydrogen atom or a lower alkyl group,

w represents an oxygen atom, a group-NH-, or a sulfur atom,

u represents a number of 0 or 1,

R⁶represents a 5-to 15-membered monocyclic, bicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms (wherein the heterocyclic group may have 1 to 3 substituents selected from the group consisting of an oxy group, a lower alkoxy group which may have a halogen atom as a substituent, a lower alkyl group which may have a halogen atom as a substituent, a halogen atom, a lower alkylsulfonyl group, a phenyl group which may be substituted on the phenyl ring by a lower alkyl group which may have a halogen atom, a lower alkylthio group, a pyrrolyl group, a benzoyl group, a lower alkanoyl group, a lower alkoxycarbonyl group and a saturated or unsaturated heterocyclic group which may have a lower alkyl group and a lower alkanoyl group selected from the group consisting of a lower alkyl group and a lower alkanoyl groupAmino group as a substituent for a group selected from the group consisting of lower alkyl group, halogen atom and amino group which may have a group selected from the group consisting of lower alkyl group and lower alkanoyl group as a substituent, alkyl group which may have a lower alkoxy group as a substituent, cycloalkyl group which may be substituted on the cycloalkyl ring by a group selected from the group consisting of lower alkyl group which may have lower alkyl group and lower alkyl group which may have a halogen atom as a substituent, lower alkenyl group which may have a halogen atom as a substituent, lower alkanoyl group, benzoyl group (which may have 1 to 3 groups selected from the group consisting of lower alkyl group which may have a halogen atom and a halogen atom on the benzene ring) lower alkyl group which may have a halogen atom as a substituent, cycloalkyl lower alkyl group or naphthyl group (wherein 1 to 3 groups selected from the group consisting of lower alkyl group which may have a halogen atom and a halogen atom on the benzene ring), lower alkyl group which may have a halogen atom as a

[ general formula 5]

The group of (a) or (b),

R⁷represents a hydrogen atom, a phenyl group, a carboxyl group, a hydroxyl group, a halogen atom, a lower alkyl group which may have a halogen atom as a substituent, a phenoxy group, a lower alkoxy group which may have a halogen atom as a substituent, a lower alkylenedioxy group, an amino group which may have a group selected from the group consisting of a lower alkyl group, a lower alkanoyl group, a benzoyl group and a cycloalkyl group as a substituent, a cyano group, a lower alkanoyl group which may have a halogen atom as a substituent, a lower alkylsulfonyl group, an aminosulfonyl group, a lower alkoxycarbonyl group, a lower alkanoyloxy group, a lower alkoxycarbonyl lower alkyl group or a 5-or 6-membered saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms (wherein, the heterocyclic group may have an oxy group),

m represents an integer of 1 to 5 (when m represents 2 to 5, 2 to 5R⁷May be the same or different); and

R²represents a hydrogen atom or a halogen atomOr lower alkyl;

y represents a group-O-, a group-N (R)⁵) -, a group-CO-, a group-CH (OH) -, a lower alkylene group, a group-S (O) N-or a group-C (═ N-OH) -,

R⁵represents a hydrogen atom, a lower alkyl group, a lower alkanoyl group, a benzoyl group, a phenyl lower alkyl group or a cycloalkyl group,

n represents 0, 1 or 2;

A represents

[ general formula 6]

Group of (A) or

[ general formula 7]

The group of (a) or (b),

p represents a number of 1 or 2,

R³represents a hydrogen atom, a lower alkoxy group, a halogen atom, a lower alkyl group which may have a halogen atom as a substituent, a lower alkoxycarbonyl group, a carboxyl group, a group-CONR¹¹R¹²Or a cyano group,

wherein R is¹¹And R¹²May be the same or different and each represents a hydrogen atom, a lower alkyl group, a cycloalkyl group or a phenyl group, and R¹¹And R¹²Can be directly connected with each other or through nitrogen atoms, oxygen atoms or sulfur atoms, and form a 5-7-membered saturated heterocyclic ring together with the nitrogen atoms connected with the saturated heterocyclic ring,

R⁴represents imidazolyl lower alkyl, 1, 2, 4-triazolyl lower alkyl, 1, 2,3-triazolyl lower alkyl group, 1, 2, 5-triazolyl lower alkyl group, pyrazolyl lower alkyl group, pyrimidinyl lower alkyl group which may have an oxy group as a substituent on the pyrimidine ring, 3, 5-dioxoisoxazolidin-4-ylidene lower alkyl group, 1, 2, 4-oxadiazolyl lower alkyl group which may have a lower alkyl group as a substituent on the 1, 2, 4-oxadiazolyl ring, thiazolidinyl lower alkyl group which may have an oxy group as a substituent on the thiazolidine ring, and pharmaceutically acceptable salts thereof,

[ general formula 8]

A group of,

[ general formula 9]

Group of (2) or group- (T)₁-N(R¹⁴)R¹⁵，

R¹³Represents a hydrogen atom, a lower alkyl group which may have a halogen atom as a substituent, a lower alkanoyl group which may have a halogen atom as a substituent, a lower alkoxycarbonyl group, a phenyl lower alkyl group which may have a lower alkylenedioxy group as a substituent on the phenyl ring, an imidazolyl lower alkyl group, a lower alkoxycarbonyl lower alkyl group, a carboxy lower alkyl group, a benzoyl group, a lower alkanoyl group substituted with a morpholinyl group, a piperazinylcarbonyl lower alkyl group which may be substituted on the piperazine ring by a phenyl lower alkyl group which may have a lower alkylenedioxy group as a substituent on the phenyl ring, a piperazinylcarbonyl lower alkanoyl group which may be substituted on the piperazine ring by a phenyl lower alkyl group which may have a lower alkylenedioxy group as a substituent on the phenyl ring, a lower alkyl group substituted with a morpholinylcarbonyl group or an imidazolyl lower alkanoyl group,

R^13aRepresents a hydrogen atom or a hydroxyl group,

t represents a lower alkylene group, a group-N (R)¹⁷)-B₃-CO-, group-B₁₉-N(R¹⁸) -CO-, group-B₄-CO-, group-Q-B₅-CO-, group-B₆-N(R¹⁹)-B₇-CO-, group-CO-B₈-, the group-CH (OH) -B₉-, the radical-CO-B₁₀-CO-, a group-CH (OH) -B₁₁-CO-, group-SO₂-or a group-B_23a-CO-CO-，

Wherein R is¹⁷Represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, a cycloalkylcarbonyl group, a lower alkanoyl group which may have a halogen atom as a substituent, a lower alkenyl group, a lower alkanoyl group which may have an amino group which may have a lower alkyl group as a substituent or a lower alkylsulfonyl group,

B₃represents a lower alkylene group, and is represented by,

B₁₉represents a lower alkylene group, and is represented by,

R¹⁸represents a hydrogen atom or a lower alkyl group,

B₄represents a lower alkylene group or a lower alkylene group which may have a hydroxyl group as a substituent,

q represents an oxygen atom or a group-S (O) n- (wherein n is the same as defined above),

B₅represents a lower alkylene group, and is represented by,

B₆represents a lower alkylene group, and is represented by,

R¹⁹represents a hydrogen atom or a lower alkanoyl group,

B₇represents a lower alkylene group, and is represented by,

B₈represents a lower alkylene group, and is represented by,

B₉represents a lower alkylene group, and is represented by,

B₁₀represents a lower alkylene group, and is represented by,

B₁₁represents a lower alkylene group, and is represented by,

B_23arepresents a lower alkylene group, and is represented by,

l represents a number of 0 or 1,

R¹⁴represents a hydrogen atom or an alkyl group which may have a hydroxyl group as a substituent,

R¹⁵Represents (2) a hydroxy-substituted alkyl group, (3) a cycloalkyl group which may have a group selected from the group consisting of a hydroxy group and a lower alkyl group as a substituent, (4) a phenoxy lower alkyl group, (5) a phenyl group which may be substituted on the phenyl ring by 1 to 3 groups selected from the group consisting of a lower alkyl group, a lower alkoxy group which may have a halogen atom as a substituent, a halogen atom, an amino lower alkoxy group which may have a lower alkyl group as a substituent, a hydroxy-substituted lower alkyl group, a phenyl lower alkyl group, a lower alkynyl group, an amino group which may have a lower alkylsulfonyl group as a substituent, a lower alkylthio group, a cycloalkyl group, a phenylthio group, an adamantyl group, an anilino group which may have a halogen atom as a substituent on the phenyl ring, a lower alkoxycarbonyl group, a piperazinyl group which may have a lower alkyl group as a substituent on the piperazine ring, a pyrrolidinyl group which may have an oxy group as, Among the lower alkanoylamino, cyano and phenoxy groups, (6) phenoxy group, (7) phenyl lower alkyl group which may be substituted on the benzene ring by 1 to 3 groups selected from halogen atom, lower alkoxy group which may have halogen atom as a substituent and lower alkyl group, (8) phenyl lower alkyl group which may have lower alkylenedioxy group as a substituent on the benzene ring, (10) lower alkyl group substituted by lower alkoxycarbonyl group, (11) lower alkyl group substituted by carboxyl group, (12) amino group which may have lower alkanoyl group as a substituent, (13) 1, 2, 3, 4-tetrahydroquinolyl group which may have 1 to 3 groups as a substituent on the tetrahydroquinoline ring, which groups are selected from oxy group, lower alkoxy group and lower alkylenedioxy group, (14) cycloalkyl lower alkyl group, (15) piperazinyl lower alkanoyl group which may be substituted on the piperazine ring by phenyl lower alkyl group which may have lower alkylenedioxy group as a substituent on the benzene ring, (16) pyridyl lower alkyl, (17) may have a substituent selected from the group consisting of lower alkyl and lower alkanoyl Amino-substituted lower alkyl group as a substituent for the group in the group, (18) lower alkoxy lower alkyl group, (19) imidazolyl group, (20) imidazolyl group lower alkyl group, (21)1, 2, 3, 4-tetrahydroisoquinolinylcarbonyl-substituted lower alkyl group, (22) piperidinylcarbonyl group which may have a group selected from lower alkoxycarbonyl group, phenyl lower alkyl group and furyl lower alkyl group as a substituent on the piperidine ring, (23) thiazolidinyl lower alkanoyl group which may have an oxygen group as a substituent on the thiazolidine ring, (24) piperidinyl group which may be substituted by a group selected from lower alkoxycarbonyl group, phenyl lower alkyl group, benzoyl group and furyl lower alkyl group on the piperidine ring, (25) piperidinyl group which may be substituted by a group selected from lower alkoxycarbonyl group, phenyl lower alkyl group, benzoyl group and furyl lower alkyl group, (

[ general formula 10]

A carbonyl lower alkyl group substituted with (26) a carbonyl lower alkyl group substituted with

[ general formula 11]

A carbonyl lower alkyl group substituted with a group of (1), (27) a group of-CO-B₂₀-N(R³⁶)R³⁷(26a) pyrrolidinyl lower alkyl, (27a) morpholinyl lower alkyl, (28a) phenyl lower alkenyl, (29a) anilinocarbonyl lower alkyl which may have lower alkyl as a substituent on the benzene ring, (30a) indolyl, (31a) piperazinyl lower alkyl which may have a group selected from lower alkyl and phenyl lower alkyl which may have lower alkylenedioxy as a substituent on the benzene ring as a substituent on the piperazine ring, (32a) amidino lower alkyl which may have lower alkyl as a substituent, (33a) fluorenyl, (34a) carbazolyl which may have lower alkyl as a substituent on the carbazole ring, (35a) amidino which may have lower alkyl as a substituent, (36a) carbazolyl which may have lower alkyl as a substituent on the piperazine ring Piperazinyl-substituted oxalyl group as a substituent, the group being selected from phenyl lower alkyl (which may have 1 to 3 groups selected from lower alkylenedioxy and lower alkoxy as substituents on the phenyl ring) and pyridyl lower alkyl, or (37a) cyano-substituted lower alkyl,

R³⁴represents an oxy group or a phenyl group,

d represents an integer of 0 to 3,

B₂₀represents a lower alkylene group, and is represented by,

R³⁶and R³⁷May be linked to each other directly or through a nitrogen atom, an oxygen atom or a sulfur atom, and may form a 5-to 7-membered saturated heterocyclic ring together with the nitrogen atom to which they are linked, wherein on the heterocyclic ring, 1 to 3 phenyl-lower alkyl groups which may have a lower alkylenedioxy group on the benzene ring may be present as substituents,

R¹⁴and R¹⁵Can be linked to each other directly or through a nitrogen atom, oxygen atom or sulfur atom, and form a 5-to 10-membered saturated or unsaturated heterocyclic ring together with the nitrogen atom to which they are linked, or

[ general formula 12]

The group of (a) or (b),

wherein, on the heterocyclic ring, 1 to 3 substituents selected from the group consisting of: (28) a phenyl-substituted lower alkyl group having 1 to 2 phenyl groups which may have a pyridyl group on the lower alkyl group, the phenyl group being substituted on the phenyl ring by 1 to 3 groups selected from the group consisting of a lower alkanoyl group, an amino group which may have a lower alkanoyl group as a substituent, a lower alkoxycarbonyl group, a cyano group, a nitro group, a phenyl group, a halogen atom, a lower alkyl group which may have a halogen atom as a substituent, a lower alkoxy group which may have a halogen atom as a substituent, a phenyl lower alkoxy group, a hydroxyl group and a lower alkylenedioxy group, (29) a carbamoyl group, (30) a pyridyl lower alkyl group which may have 1 to 3 groups as a substituent on the pyridine ring, the groups being selected from the group consisting of a hydroxyl group and a lower alkyl group which may have a hydroxyl group as a substituent, (31) a pyrrolyl lower alkyl group which may have 1 to 3 lower alkyl groups as a substituent on the pyrrole ring, (32) a benzoxazolyl lower alkyl group, (33) benzothiazolyl lower alkyl, (34) furanyl lower alkyl, (35) benzoyl which may be substituted on the benzene ring by 1 to 3 groups selected from cyano, amino which may have lower alkylsulfonyl as a substituent, halogen atom, lower alkoxy, lower alkyl which may have halogen atom as a substituent, thiazolidinyl lower alkyl which may have oxy as a substituent on the thiazolidine ring, and lower alkylenedioxy, (36) pyrimidinyl, (37) pyrazinyl, (38) pyridyl, (39) lower alkoxycarbonyl, (40) thiazolinyl which may have oxy as a substituent on the thiazolidine ring, and (3) benzoyl which may be substituted on the benzene ring by a group selected from oxy and lower alkylenedioxy

[ general formula 13]

Group (wherein R)^aAnd R^bEach represents a lower alkyl group), (41) a lower alkyl group which may have a group selected from the group consisting of a hydroxyl group and a halogen atom as a substituent, (42) a lower alkanoyl group which may have a halogen atom as a substituent, (43) a phenyl group which may be substituted on the benzene ring by 1 to 3 groups selected from the group consisting of a carbamoyl group which may have a group selected from the group consisting of a lower alkoxy lower alkyl group and a lower alkyl group, a lower alkoxycarbonyl group, a carboxyl group, a cyano group, a phenyl group, a halogen atom, a lower alkyl group which may have a halogen atom as a substituent, a lower alkoxy group which may have a halogen atom as a substituent, a benzoyl group which may have a halogen atom as a substituent on the benzene ring, a phenyl lower alkyl group which may have a halogen atom as a substituent on the benzene ring and a hydroxyl group, (44) a thiazolidinyl lower alkanoyl group which may have a group selected from the group on thePhenyl having a lower alkylenedioxy group as a substituent, (45) naphthyl lower alkyl, (46) phenoxy which may be substituted on the phenyl ring by 1 to 3 groups selected from cyano, lower alkyl which may have a halogen atom as a substituent and lower alkoxy which may have a halogen atom as a substituent, (47) phenoxy lower alkyl, (48) phenyl lower alkoxy which may be substituted on the phenyl ring by 1 to 3 groups selected from a halogen atom, lower alkyl which may have a halogen atom as a substituent and lower alkoxy which may have a halogen atom as a substituent, (49) group- (B) ₁₂CO)t-N(R²⁰)R²¹(50) group- (CO) o-B₁₃-N(R²²)R²³(51) a lower alkyl group substituted with 1, 2, 3, 4-tetrahydronaphthyl group which may be substituted with 1 to 5 lower alkyl groups as substituents on the 1, 2, 3, 4-tetrahydronaphthyl ring, (52) a cycloalkyl group which may have a hydroxyl group as a substituent, (53) a piperidinyl group which may be substituted with 1 to 3 lower alkyl groups as substituents on the piperidine ring, (54) a quinolyl lower alkyl group, (55) a 1, 2, 3, 4-tetrazolyl lower alkyl group which may have a group selected from lower alkyl groups and phenyl lower alkyl groups as substituents on the tetrazole ring, (56) a thiazolyl lower alkyl group which may have a phenyl group as a substituent on the thiazole ring, (57) a benzoyl lower alkyl group which may have 1 to 3 groups selected from lower alkoxy groups and halogen atoms as substituents on the benzene ring, (58) a piperidinyl lower alkyl group which may have a lower alkyl group as substituents on the piperidine ring, (59) an imidazolyl group which may have 1 to 3 phenyl groups as substituents on the imidazole ring, (60) a benzimidazolyl group which may have 1 to 3 lower alkyl groups as substituents on the benzimidazole ring, (61) a pyridyl lower alkoxy group, (62) a 1, 2, 3, 4-tetrahydroquinolyl lower alkyl group which may have an oxy group as substituents on the tetrahydroquinoline ring, (63) a 1, 3, 4-oxadiazolyl lower alkyl group which may have an oxy group as substituents on the 1, 3, 4-oxadiazolyl ring, (64) a cycloalkyl lower alkyl group, (65) a tetrahydropyranyl group, (66) a thienyl lower alkyl group, (67) a pyrimidylcarbonyl group which may have an oxy group as substituents on the pyrimidine ring, (68) a hydroxyl group, (69) a carboxyl group, (70) a lower alkoxy lower alkyl group, (71) a lower alkoxy group, (72) a benzoyloxy group, (73) lower alkoxycarbonyl Lower alkoxy, (74) carboxy lower alkoxy, (75) phenoxy lower alkanoyl, (76) 1, 2, 3, 4-tetrahydroquinolinecarbonyl which may have an oxy group as a substituent on the tetrahydroquinoline ring, (77) phenylsulfonyl, (78) imidazolyl lower alkanoyl, (79) imidazolyl lower alkyl, (80) pyridylcarbonyl, (81) imidazolyl carbonyl, (82) lower alkoxycarbonyl lower alkyl, (83) carboxy lower alkyl, (84) group- (O-B)₁₅)s-CO-N(R²⁶)R²⁷(85) group-N (R)²⁸)-CO-B₁₆-N(R²⁹)R³⁰(86) group-N (R)³¹)-B₁₇-CO-N(R³²)R³³(87) a benzoxazolyl group, (88a) a benzothienyl group, (89a) an oxy group and (90a) a 1, 2, 3, 4-tetrahydroquinolyl group which may have an oxy group as a substituent on the tetrahydroquinoline ring,

B₁₂represents a lower alkylene group, and is represented by,

t represents a number of 0 or 1,

R²⁰and R²¹May be the same or different and each represents: a hydrogen atom; an amino group which may have a lower alkoxycarbonyl group as a substituent; a benzoyl group which may have 1 to 3 lower alkoxy groups as substituents on the benzene ring; a lower alkyl group; a lower alkyl group having 1 to 2 phenyl groups which may be substituted on the phenyl ring with 1 to 3 groups selected from the group consisting of a lower alkoxycarbonyl group, a cyano group, a nitro group, a phenyl group, a halogen atom, a lower alkyl group which may have a halogen atom as a substituent, a lower alkoxy group which may have a halogen atom as a substituent, and a lower alkylthio group; a phenyl group which may be substituted on the phenyl ring with 1 to 3 groups selected from a lower alkoxy group which may have a halogen atom as a substituent and a lower alkyl group which may have a halogen atom as a substituent; a lower alkoxycarbonyl group; cycloalkyl lower alkyl; a pyrrolidinyl lower alkyl group which may have 1 to 3 lower alkyl groups which may have a hydroxyl group as a substituent on the pyrrolidine ring; lower alkyl substituted with amino which may have a group selected from phenyl and lower alkyl as a substituent; a lower alkyl group substituted with 1, 2, 3, 4-tetrahydronaphthyl group which may have 1 to 5 lower alkyl groups as substituents on the 1, 2, 3, 4-tetrahydronaphthyl ring; naphthyl lower An alkyl group; pyridyl lower alkyl; quinolinyl lower alkyl; 1, 2, 3, 4-tetrazolyl lower alkyl group which may have 1 to 3 groups selected from lower alkyl groups and phenyl lower alkyl groups as substituents on the tetrazole ring; 1, 2, 4-triazolyl lower alkyl; tetrahydrofuranyl lower alkyl which may have a hydroxy group as a substituent on the lower alkyl; a phenoxy lower alkyl group which may have 1 to 3 groups selected from a lower alkyl group and a nitro group as substituents on a benzene ring; phenyl lower alkanoyl; a lower alkanoyl group which may have a halogen atom as a substituent; imidazolyl lower alkanoyl; lower alkoxycarbonyl lower alkyl; a pyridyl group; or carboxy lower alkyl, or cycloalkyl; and R is²⁰And R²¹May be linked to each other directly or through a nitrogen atom, an oxygen atom or a sulfur atom, and together with the nitrogen atom to which they are linked to form a 5-7-membered saturated heterocyclic ring (wherein, on the heterocyclic ring, 1 to 3 substituents selected from the group consisting of a lower alkyl group, a phenyl group which may have on the phenyl ring 1 to 3 groups selected from the group consisting of a halogen atom and a lower alkyl group which may have a halogen atom as a substituent, and a phenyl lower alkyl group which may have on the phenyl ring a lower alkylenedioxy group as a substituent) may be present,

o represents a number of 0 or 1,

B₁₃represents a lower alkylene group, and is represented by,

R²²and R²³May be the same or different and each represents a hydrogen atom, a lower alkyl group, a benzoyl group which may have 1 to 3 lower alkoxy groups as substituents on the phenyl ring, a phenoxy lower alkyl group which may have a lower alkyl group as substituents on the phenyl ring, a phenyl lower alkyl group or a phenyl group, or R²²And R²³May be linked to each other directly or through a nitrogen atom, an oxygen atom or a sulfur atom, together with the nitrogen atom to which they are linked to form a 5-to 7-membered saturated heterocyclic ring (wherein, on the heterocyclic ring, 1 to 3 substituents selected from the group consisting of a lower alkyl group and a phenyl lower alkyl group which may have a lower alkylenedioxy group as a substituent on the phenyl ring may be present),

B₁₅represents a lower alkylene group, and is represented by,

s represents a number of 0 or 1,

R²⁶and R²⁷Which may be the same or different, each represents a hydrogen atom, a lower alkyl group, a phenyl lower alkyl group or an imidazolyl lower alkyl group, and R²⁶And R²⁷May be linked to each other directly or through a nitrogen atom, an oxygen atom or a sulfur atom, and may be taken together with the nitrogen atom to which they are linked to form a 5-to 7-membered saturated heterocyclic ring (wherein, on the heterocyclic ring, 1 to 3 phenyl-lower alkyl groups which may have a lower alkylenedioxy group as a substituent on the benzene ring may be present as substituents),

R²⁸Represents a hydrogen atom or a lower alkyl group,

B₁₆represents a lower alkylene group, and is represented by,

R²⁹and R³⁰May be linked to each other directly or through a nitrogen atom, an oxygen atom or a sulfur atom, together with the nitrogen atom to which they are linked to form a 5-to 7-membered saturated heterocyclic ring, wherein, on the heterocyclic ring, 1 to 3 substituents selected from the group consisting of lower alkyl, phenyl and phenyl lower alkyl which may have a lower alkylenedioxy group as a substituent on the phenyl ring may be present,

R³¹represents a hydrogen atom or a lower alkyl group,

B₁₇represents a lower alkylene group, and is represented by,

R³²and R³³May be linked to each other directly or through a nitrogen atom, an oxygen atom or a sulfur atom, together with the nitrogen atom to which they are linked to form a 5-to 7-membered saturated heterocyclic ring (wherein, on the heterocyclic ring, 1 to 3 substituents selected from the group consisting of lower alkyl, phenyl and phenyl lower alkyl which may have a lower alkylenedioxy group as a substituent on the phenyl ring may be present),

however, the above-mentioned compound or a salt thereof satisfies the following requirements (i) to (v):

(i)X₁when represents a group-CH ═ then R³Represents a hydrogen atom;

(ii)X₁represents a group-CH ═ l represents 1, T represents-CO-, and R¹⁴When represents a hydrogen atom or an alkyl group which may have a hydroxyl group as a substituent, then R¹⁵Represents a group (24);

(iii)X₁Represents a group-CH ═ l represents 1, and T represents-N (R)¹⁷)-B₃when-CO-then R¹⁴And R¹⁵May be linked to each other directly or through a nitrogen atom, oxygen atom or sulfur atom, and together with the nitrogen atom to which they are linked, to form a 5-to 10-membered saturated or unsaturated heterocyclic ring, wherein, on said heterocyclic ring, 1 to 3 groups (28) may be present as substituents;

(iv)X₁represents a nitrogen atom, and l represents 0, or X₁Represents a nitrogen atom, l represents 1, and T represents-CO-or-SO₂Then R¹⁵Is not a group (5), (7), (19) or (20); and

(v)R⁶represents a cycloalkyl group which may have a substituent selected from the group consisting of a lower alkyl group which may have a lower alkyl group substituted with an amino group and a lower alkyl group which may have a halogen atom as a substituent on the cycloalkyl ring thereof, then R⁴Represents a group- (T)₁-N(R¹⁴)R¹⁵(wherein T and l are as defined above, and R¹⁴And R¹⁵Can be directly connected with each other or through a nitrogen atom, an oxygen atom or a sulfur atom, and form a 5-10-membered saturated heterocyclic ring together with the nitrogen atom connected with the nitrogen atom; or R¹⁴And R¹⁵Form a

[ general formula 14]

The group of (1).

Item B: the inhibitor of STAT3 activation according to clause a is for use in the prevention or treatment of a symptom or disease associated with activation of STAT 3.

Item C: the inhibitor of STAT3 activation according to item B, wherein the symptom or disease associated with STAT3 activation is an autoimmune disease, diabetes, infection, central nervous disease, cancer-related disease, or psoriasis.

The present invention further provides a method for preventing or treating a symptom or disease associated with activation of STAT3 by administering to a patient an effective dose of the aromatic compound (1) according to item a or a salt thereof.

The present invention also provides the use of the aromatic compound (1) according to item a or a salt thereof for producing a STAT3/5 activation inhibitor.

The aromatic compound (1) or a salt thereof used as an active ingredient of the STAT3/5 activation inhibitor of the present invention is the aromatic compound (1) represented by the following item 1 or a salt thereof and is preferably the aromatic compound represented by items 2 to 48 or a salt thereof.

Item 1: an aromatic compound represented by the following general formula:

[ general formula 15]

Wherein, X₁Represents a nitrogen atom or a group-CH ═ CH;

R¹represents a group-Z-R⁶；

Z represents a group-N (R)⁸) -B-, group-B-N (R)⁸) -, group-B₀-O-、

[ general formula 16]

Group (b), groupThe group-CO-, the group-CH (OH) -, the group-N (R)^9a)-CO-N-(R^9b) -, group-N ═ CH-, group-N (R)^10a)-SO₂-(B_22a) e-, lower alkenylene, group-NHCO-B₁-, the radical-NHCO-B₂- (W) u-, group-B₀-O-B_19a-、

[ general formula 17]

A group of,

[ general formula 18]

Group of (a), group-SO₂-N(R^10b) -, a group-S-, a lower alkynylene group, a lower alkylene group, a group-N (R)^8d) -or a group-CO-NH-B_18a-，

R⁸Represents a hydrogen atom, a lower alkyl group which may have a lower alkoxy group as a substituent, a lower alkanoyl group, a lower alkylsulfonyl group or a phenyl lower alkyl group,

B represents a group-CO-or a lower alkylene group,

B₀represents a lower alkylene group, and is represented by,

R^9arepresents a hydrogen atom or a lower alkyl group,

R^9brepresents a hydrogen atom or a lower alkyl group,

R^10arepresents a hydrogen atom or a lower alkyl group,

B_22arepresents a lower alkylene group or a lower alkenylene group,

e represents a number of 0's or 1's,

B_18arepresents a lower alkylene group, and is represented by,

B_19arepresents a lower alkylene group, and is represented by,

B_20arepresents a lower alkylene group, and is represented by,

B_21arepresents a lower alkylene group, and is represented by,

k represents a number of 2 or 3,

c represents a number of 0 or 1,

d' represents a number of 0 or 1,

R^10brepresents a hydrogen atom or a lower alkyl group,

R^8drepresents a hydrogen atom or a lower alkyl group,

w represents an oxygen atom, a group-NH-or a sulphur atom,

u represents a number of 0 or 1,

R⁶represents a 5-15 membered monocyclic, bicyclic or tricyclic saturated or unsaturated heterocyclic group having 1-4 nitrogen atoms, oxygen atoms or sulfur atoms (wherein the heterocyclic ring may have 1-3 substituents selected from the group consisting of an oxy group, a lower alkoxy group which may have a halogen atom as a substituent, a lower alkyl group which may have a halogen atom as a substituent, a halogen atom, a lower alkylsulfonyl group, a phenyl group which may be substituted on the phenyl ring by a lower alkyl group which may have a halogen atom, a lower alkylthio group, a pyrrolyl group, a benzoyl group, a lower alkanoyl group, a lower alkoxycarbonyl group and an amino group which may have a group selected from the group consisting of a lower alkyl group and a lower alkanoyl group as a substituent), an adamantyl group, a naphthyl group (wherein the naphthyl ring may have 1-3 groups selected from the group consisting of a lower alkyl group, a halogen atom and a lower alkyl group which may have a halogen atom as well as a substituent), an An amino group having a group selected from a lower alkyl group and a lower alkanoyl group as a substituent), an alkyl group which may have a lower alkoxy group as a substituent, a cycloalkyl group which may be substituted on the cycloalkyl ring by a group selected from a lower alkyl group which may have a lower alkyl group and a lower alkyl group which may have a halogen atom as a substituent, a lower alkenyl group which may have a halogen atom as a substituent, a lower alkanoyl group, a benzoyl group (wherein 1 to 3 groups selected from a lower alkyl group which may have a halogen atom and a halogen atom may be present on the benzene ring as a substituent), a lower alkyl group which may be substituted by a halogen atom, a cycloalkyl lower alkyl group or a lower alkyl group which may have a halogen atom as a substituent), a cycloalkyl group

[ general formula 19]

The group of (a) or (b),

R²represents a hydrogen atom, a halogen atom or a lower alkyl group;

y represents a group-O-, a group-N (R)⁵) -, a group-CO-, a group-CH (OH) -, a groupAlkylene, a group-s (o) N-or a group-C (═ N-OH) -,

n represents 0, 1 or 2,

a represents

[ general formula 20]

Group of (A) or

[ general formula 21]

The group of (a) or (b),

p represents a number of 1 or 2,

wherein R is¹¹And R¹²May be the same or different and each represents a hydrogen atom, a lower alkyl group, a cycloalkyl group or a phenyl group, and R¹¹And R¹²Can be directly connected with each other or through a nitrogen atom, an oxygen atom or a sulfur atom, and form a 5-to 7-membered saturated heterocyclic ring together with the nitrogen atom connected therewith,

R⁴represents imidazolyl lower alkyl, 1, 2, 4-triazolyl lower alkyl, 1, 2, 3-triazolyl lower alkyl, 1, 2, 5-triazolyl lower alkyl, pyrazolyl lower alkyl, pyrimidinyl lower alkyl which may have an oxy group as a substituent on the pyrimidine ring A lower alkyl group, a 3, 5-dioxoisoxazolidin-4-ylidene lower alkyl group, a 1, 2, 4-oxadiazolyl lower alkyl group which may have a lower alkyl group as a substituent on the 1, 2, 4-oxadiazole ring, a thiazolidinyl lower alkyl group which may have an oxy group as a substituent on the thiazolidine ring, a substituted amino group, a,

[ general formula 22]

A group of,

[ general formula 23]

Group of (2) or group- (T)₁-N(R¹⁴)R¹⁵，

R^13arepresents a hydrogen atom or a hydroxyl group,

T represents a lower alkylene group, a group-N (R)¹⁷)-B₃-CO-, group-B₁₉-N(R¹⁸)-CO-, group-B₄-CO-, group-Q-B₅-CO-, group-B₆-N(R¹⁹)-B₇-CO-, group-CO-B₈-, the group-CH (OH) -B₉-, the radical-CO-B₁₀-CO-, a group-CH (OH) -B₁₁-CO-, group-SO₂-or a group-B_23a-CO-CO-，

B₃represents a lower alkylene group, and is represented by,

B₁₉represents a lower alkylene group, and is represented by,

R¹⁸represents a hydrogen atom or a lower alkyl group,

B₅represents a lower alkylene group, and is represented by,

B₆represents a lower alkylene group, and is represented by,

R¹⁹represents a hydrogen atom or a lower alkanoyl group,

B₇represents a lower alkylene group, and is represented by,

B₈represents a lower alkylene group, and is represented by,

B₉represents a lower alkylene group, and is represented by,

B₁₀represents a lower alkylene group, and is represented by,

B₁₁represents a lower alkylene group, and is represented by,

B_23arepresents a lower alkylene groupThe base group is a group of a compound,

l represents a number of 0 or 1,

R¹⁵represents: (2) a hydroxy-substituted alkyl group, (3) a cycloalkyl group which may have a group selected from the group consisting of a hydroxy group and a lower alkyl group as a substituent, (4) a phenoxy lower alkyl group, (5) a phenyl group which may be substituted on the phenyl ring by 1 to 3 groups selected from the group consisting of a lower alkyl group, a lower alkoxy group which may have a halogen atom as a substituent, a halogen atom, an amino lower alkoxy group which may have a lower alkyl group as a substituent, a hydroxy-substituted lower alkyl group, a phenyl lower alkyl group, a lower alkynyl group, an amino group which may have a lower alkylsulfonyl group as a substituent, a lower alkylthio group, a cycloalkyl group, a phenylthio group, an adamantyl group, an anilino group which may have a halogen atom as a substituent on the phenyl ring, a lower alkoxycarbonyl group, a piperazinyl group which may have a lower alkyl group as a substituent on the piperazine ring, a pyrrolidinyl group which may have an oxy group as, Among the lower alkanoylamino, cyano and phenoxy groups, (6) phenoxy group, (7) phenyl lower alkyl group which may be substituted on the benzene ring by 1 to 3 groups selected from halogen atom, lower alkoxy group which may have halogen atom as a substituent and lower alkyl group, (8) phenyl lower alkyl group which may have lower alkylenedioxy group as a substituent on the benzene ring, (10) lower alkyl group substituted by lower alkoxycarbonyl group, (11) lower alkyl group substituted by carboxyl group, (12) amino group which may have lower alkanoyl group as a substituent, (13) 1, 2, 3, 4-tetrahydroquinolyl group which may have 1 to 3 groups as a substituent on the tetrahydroquinoline ring, which groups are selected from oxy group, lower alkoxy group and lower alkylenedioxy group, (14) cycloalkyl lower alkyl group, (15) piperazinyl lower alkanoyl group which may be substituted on the piperazine ring by phenyl lower alkyl group which may have lower alkylenedioxy group as a substituent on the benzene ring, (16) pyridyl lower alkyl group, (17) amino-substituted lower alkyl group which may have a group selected from lower alkyl group and lower alkanoyl group as a substituent, (18) lower alkoxy lower alkyl group, (19) imidazolyl group, (20) imidazolyl group lower alkyl group, (21) lower alkoxy group )1, 2, 3, 4-tetrahydroisoquinolinylcarbonyl substituted lower alkyl, (22) piperidinylcarbonyl which may have as a substituent a group selected from the group consisting of lower alkoxycarbonyl, phenyl lower alkyl and furyl lower alkyl on the piperidine ring, (23) thiazolidinyl lower alkanoyl which may have as a substituent an oxygen group on the thiazolidine ring, (24) piperidinyl which may be substituted on the piperidine ring by a group selected from the group consisting of lower alkoxycarbonyl, phenyl lower alkyl, benzoyl and furyl lower alkyl, (25) piperidinyl which may be substituted by

[ general formula 24]

[ general formula 25]

A carbonyl lower alkyl group substituted with a group of (1), (27) a group of-CO-B₂₀-N(R³⁶)R³⁷(26a) Pyrrolidinyl lower alkyl, (27a) morpholinyl lower alkyl, (28a) phenyl lower alkenyl, (29a) anilinocarbonyl lower alkyl which may have lower alkyl as a substituent on the benzene ring, (30a) indolyl, (31a) piperazinyl lower alkyl which may have a group selected from lower alkyl and phenyl lower alkyl which may have lower alkylenedioxy as a substituent on the benzene ring as a substituent on the piperazine ring, (32a) amidino lower alkyl which may have lower alkyl as a substituent, (33a) fluorenyl, (34a) carbazolyl which may have lower alkyl as a substituent on the carbazole ring, (35a) amidino which may have lower alkyl as a substituent, (36a) piperazinyl substituted oxalyl which may have 1 to 3 groups as substituents on the piperazine ring, said group being selected from phenyl lower alkyl (which may have a group selected from lower alkylenedioxy on the benzene ring). 1 to 3 groups of the group and the lower alkoxy group as substituents) and pyridyl lower alkyl, or (37a) cyano-substituted lower alkyl,

R³⁴represents an oxy group or a phenyl group,

d represents an integer of 0 to 3,

B₂₀represents a lower alkylene group, and is represented by,

[ general formula 26]

The group of (a) or (b),

[ general formula 27]

Group (wherein R)^aAnd R^bEach represents a lower alkyl group), (41) a lower alkyl group which may have a group selected from a hydroxyl group and a halogen atom as a substituent, (42) a lower alkanoyl group which may have a halogen atom as a substituent, (43) a phenyl group which may be substituted on the benzene ring by 1 to 3 groups selected from a carbamoyl group which may have a group selected from a lower alkoxy lower alkyl group and a lower alkyl group, a lower alkoxycarbonyl group, a carboxyl group, a cyano group, a phenyl group, a halogen atom, a lower alkyl group which may have a halogen atom as a substituent, a lower alkoxy group which may have a halogen atom as a substituent, a benzoyl group which may have a halogen atom as a substituent on the benzene ring, a phenyl lower alkyl group which may have a halogen atom as a substituent on the benzene ring and a hydroxyl group, (44) a phenyl group which may have a lower alkylenedioxy group as a substituent on the benzene ring, (45) naphthyl lower alkyl, (46) phenoxy which may be substituted on the phenyl ring by 1 to 3 groups, saidA group selected from the group consisting of a cyano group, a lower alkyl group which may have a halogen atom as a substituent, and a lower alkoxy group which may have a halogen atom as a substituent, (47) a phenoxy lower alkyl group, (48) a phenyl lower alkoxy group which may be substituted on the phenyl ring by 1 to 3 groups selected from the group consisting of a halogen atom, a lower alkyl group which may have a halogen atom as a substituent, and a lower alkoxy group which may have a halogen atom as a substituent, (49) a group- (B) ₁₂CO)t-N(R²⁰)R²¹(50) group- (CO) o-B₁₃-N(R²²)R²³(51) a lower alkyl group substituted with 1, 2, 3, 4-tetrahydronaphthyl group which may be substituted with 1 to 5 lower alkyl groups as substituents on the 1, 2, 3, 4-tetrahydronaphthyl ring, (52) a cycloalkyl group which may have a hydroxyl group as a substituent, (53) a piperidinyl group which may be substituted with 1 to 3 lower alkyl groups as substituents on the piperidine ring, (54) a quinolyl lower alkyl group, (55) a 1, 2, 3, 4-tetrazolyl lower alkyl group which may have a group selected from lower alkyl groups and phenyl lower alkyl groups as substituents on the tetrazole ring, (56) a thiazolyl lower alkyl group which may have a phenyl group as a substituent on the thiazole ring, (57) a benzoyl lower alkyl group which may have 1 to 3 groups selected from lower alkoxy groups and halogen atoms as substituents on the benzene ring, (58) a piperidinyl lower alkyl group which may have a lower alkyl group as substituents on the piperidine ring, (59) an imidazolyl group which may have 1 to 3 phenyl groups as substituents on the imidazole ring, (60) a benzimidazolyl group which may have 1 to 3 lower alkyl groups as substituents on the benzimidazole ring, (61) a pyridyl lower alkoxy group, (62) a 1, 2, 3, 4-tetrahydroquinolyl lower alkyl group which may have an oxy group as substituents on the tetrahydroquinoline ring, (63) a 1, 3, 4-oxadiazolyl lower alkyl group which may have an oxy group as substituents on the 1, 3, 4-oxadiazolyl ring, (64) a cycloalkyl lower alkyl group, (65) a tetrahydropyranyl group, (66) a thienyl lower alkyl group, (67) a pyrimidylcarbonyl group which may have an oxy group as substituents on the pyrimidine ring, (68) a hydroxyl group, (69) a carboxyl group, (70) a lower alkoxy lower alkyl group, (71) a lower alkoxy group, (72) a benzoyloxy group, (73) lower alkoxycarbonyl lower alkoxy, (74) carboxy lower alkoxy, (75) phenoxy lower alkanoyl, (76) 1, 2 which may have an oxy group as a substituent on the tetrahydroquinoline ring, 3, 4-tetrahydroquinolinylcarbonyl, (77) phenylsulfonyl, (78) imidazolyl-lower alkanoyl, (79) imidazolyl-lower alkyl, (80) pyridylcarbonyl, (81) imidazolyl-carbonyl, (82) lower alkoxycarbonyl-lower alkyl, (83) carboxy-lower alkyl, (84) group- (O-B)₁₅)s-CO-N(R²⁶)R²⁷(85) group-N (R)²⁸)-CO-B₁₆-N(R²⁹)R³⁰(86) group-N (R)³¹)-B₁₇-CO-N(R³²)R³³(87) a benzoxazolyl group, (88a) a benzothienyl group, (89a) an oxy group and (90a) a 1, 2, 3, 4-tetrahydroquinolyl group which may have an oxy group as a substituent on the tetrahydroquinoline ring,

B₁₂represents a lower alkylene group, and is represented by,

t represents a number of 0 or 1,

R²⁰and R²¹May be the same or different and each represents: a hydrogen atom; an amino group which may have a lower alkoxycarbonyl group as a substituent; benzoyl which may have 1 to 3 lower alkoxy groups as substituents on the phenyl ring, lower alkyl; a lower alkyl group having 1 to 2 phenyl groups which may be substituted on the phenyl ring with 1 to 3 groups selected from the group consisting of a lower alkoxycarbonyl group, a cyano group, a nitro group, a phenyl group, a halogen atom, a lower alkyl group which may have a halogen atom as a substituent, a lower alkoxy group which may have a halogen atom as a substituent, and a lower alkylthio group; a phenyl group which may be substituted on the phenyl ring with 1 to 3 groups selected from a lower alkoxy group which may have a halogen atom as a substituent and a lower alkyl group which may have a halogen atom as a substituent; a lower alkoxycarbonyl group; cycloalkyl lower alkyl; a pyrrolidinyl lower alkyl group which may have 1 to 3 lower alkyl groups which may have a hydroxyl group as a substituent on the pyrrolidine ring; lower alkyl substituted with amino which may have a group selected from phenyl and lower alkyl as a substituent; a lower alkyl group substituted with 1, 2, 3, 4-tetrahydronaphthyl group which may have 1 to 5 lower alkyl groups as substituents on the 1, 2, 3, 4-tetrahydronaphthyl ring; naphthyl lower alkyl; pyridyl lower alkyl; quinolinyl lower alkyl; may have 1 to 3 groups selected from lower alkyl and phenyl lower alkyl on the tetrazole ring as Substituted 1, 2, 3, 4-tetrazolyl lower alkyl; 1, 2, 4-triazolyl lower alkyl; tetrahydrofuranyl lower alkyl which may have a hydroxy group as a substituent on the lower alkyl; a phenoxy lower alkyl group which may have 1 to 3 groups selected from a lower alkyl group and a nitro group as substituents on a benzene ring; phenyl lower alkanoyl; a lower alkanoyl group which may have a halogen atom as a substituent; imidazolyl lower alkanoyl; lower alkoxycarbonyl lower alkyl; a pyridyl group; or carboxy lower alkyl, or cycloalkyl; and R is²⁰And R²¹May be linked to each other directly or through a nitrogen atom, an oxygen atom or a sulfur atom, and together with the nitrogen atom to which they are linked to form a 5-7-membered saturated heterocyclic ring (wherein, on the heterocyclic ring, 1 to 3 substituents selected from the group consisting of a lower alkyl group, a phenyl group which may have on the phenyl ring 1 to 3 groups selected from the group consisting of a halogen atom and a lower alkyl group which may have a halogen atom as a substituent, and a phenyl lower alkyl group which may have on the phenyl ring a lower alkylenedioxy group as a substituent) may be present,

o represents a number of 0 or 1,

B₁₃represents a lower alkylene group, and is represented by,

R²²and R²³May be the same or different and each represents a hydrogen atom, a lower alkyl group, a benzoyl group which may have 1 to 3 lower alkoxy groups as substituents on the phenyl ring, a phenoxy lower alkyl group which may have a lower alkyl group as substituents on the phenyl ring, a phenyl lower alkyl group or a phenyl group, or R ²²And R²³May be linked to each other directly or through a nitrogen atom, an oxygen atom or a sulfur atom, together with the nitrogen atom to which they are linked to form a 5-to 7-membered saturated heterocyclic ring (wherein, on the heterocyclic ring, 1 to 3 substituents selected from the group consisting of a lower alkyl group and a phenyl lower alkyl group which may have a lower alkylenedioxy group as a substituent on the phenyl ring may be present),

B₁₅represents a lower alkylene group, and is represented by,

s represents a number of 0 or 1,

R²⁶and R²⁷Can be combined with each otherAre the same or different and each represents a hydrogen atom, a lower alkyl group, a phenyl lower alkyl group or an imidazolyl lower alkyl group, and R²⁶And R²⁷May be linked to each other directly or through a nitrogen atom, an oxygen atom or a sulfur atom, and may be taken together with the nitrogen atom to which they are linked to form a 5-to 7-membered saturated heterocyclic ring (wherein, on the heterocyclic ring, 1 to 3 phenyl-lower alkyl groups which may have a lower alkylenedioxy group as a substituent on the benzene ring may be present as substituents),

R²⁸represents a hydrogen atom or a lower alkyl group,

B₁₆represents a lower alkylene group, and is represented by,

R³¹Represents a hydrogen atom or a lower alkyl group,

B₁₇represents a lower alkylene group, and is represented by,

(i)X₁when represents a group-CH ═ then R³Represents a hydrogen atom;

(ii)X₁represents a group-CH ═ l represents 1, T represents-CO-, and R¹⁴Represents a hydrogen atom or may haveWhen there is an alkyl group having a hydroxyl group as a substituent, then R¹⁵Represents a group (24);

(iv)X₁represents a nitrogen atom, and l represents 0, or X₁Represents a nitrogen atom, l represents 1, and T represents-CO-or-SO ₂Then R¹⁵Is not a group (5), (7), (19) or (20); and

(v)R⁶represents a cycloalkyl group which may have a substituent selected from the group consisting of a lower alkyl group which may have a lower alkyl group substituted with an amino group and a lower alkyl group which may have a halogen atom as a substituent on the cycloalkyl ring thereof, then R⁴Represents a group- (T)_l-N(R¹⁴)R¹⁵(wherein T and l are as defined above, and R¹⁴And R¹⁵Can be directly connected with each other or through a nitrogen atom, an oxygen atom or a sulfur atom, and form a 5-10-membered saturated heterocyclic ring together with the nitrogen atom connected with the nitrogen atom; or R¹⁴And R¹⁵Form a

[ general formula 28]

The group of (1).

Item 2: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-1) to (1-7) or a salt thereof as an active ingredient:

[ general formula 29]

Wherein, Y₃Represents a lower alkylene group.

Item 3: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-8) to (1-14) or a salt thereof as an active ingredient:

[ general formula 30]

Wherein, Y₃Represents a lower alkylene group.

Item 4: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-15) to (1-21) or a salt thereof as an active ingredient:

[ general formula 31]

Wherein, Y₃Represents a lower alkylene group.

Item 5: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-22) to (1-28) or a salt thereof as an active ingredient:

[ general formula 32]

Wherein, Y₃Represents a lower alkylene group.

Item 6: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-29) to (1-35) or a salt thereof as an active ingredient:

[ general formula 33]

Wherein, Y₃Represents a lower alkylene group.

Item 7: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-36) to (1-42) or a salt thereof as an active ingredient:

[ general formula 34]

Wherein, Y₃Represents a lower alkylene group.

Item 8: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-43) to (1-49) or a salt thereof as an active ingredient:

[ general formula 35]

Wherein, Y₃Represents a lower alkylene group.

Item 9: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-50) to (1-56) or a salt thereof as an active ingredient:

[ general formula 36]

Wherein, Y₃Represents a lower alkylene group.

Item 10: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-57) to (1-63) or a salt thereof as an active ingredient:

[ general formula 37]

Wherein, Y₃Represents a lower alkylene group.

Item 11: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-64) to (1-70) or a salt thereof as an active ingredient:

[ general formula 38]

Wherein, Y₃Represents a lower alkylene group, and Z₁Represents a lower alkenylene group.

Item 12: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-71) to (1-77) or a salt thereof as an active ingredient:

[ general formula 39]

Wherein, Y₃Represents a lower alkylene group.

Item 13: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-78) to (1-84) or a salt thereof as an active ingredient:

[ general formula 40]

Wherein, Y₃Represents a lower alkylene group.

Item 14: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-85) to (1-91) or a salt thereof as an active ingredient:

[ general formula 41]

Wherein, Y₃Represents a lower alkylene group.

Item 15: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-92) to (1-98) or a salt thereof as an active ingredient:

[ general formula 42]

Wherein, Y₃Represents a lower alkylene group.

Item 16: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-99) to (1-105) or a salt thereof as an active ingredient:

[ general formula 43]

Wherein, Y₃Represents a lower alkylene group.

Item 17: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-106) to (1-112) or a salt thereof as an active ingredient:

[ general formula 44]

Wherein, Y₃Represents a lower alkylene group.

Item 18: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-113) to (1-119) or a salt thereof as an active ingredient:

[ general formula 45]

Wherein, Y₃Represents a lower alkylene group.

Item 19: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-120) to (1-126) or a salt thereof as an active ingredient:

[ general formula 46]

Wherein, Y₃Represents a lower alkylene group, and Z₂Represents a lower alkynylene group.

Item 20: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-127) to (1-133) or a salt thereof as an active ingredient:

[ general formula 47]

Wherein, Y₃Represents a lower alkylene group.

Item 21: the aromatic compound or a salt thereof according to claim 1, which comprises a compound selected from the group consisting of compounds represented by the following general formulae (1-134) to (1-140) or a salt thereof as an active ingredient:

[ general formula 48]

Wherein, Y₃Represents a lower alkylene group, and Z₃Represents a lower alkylene group or a group-N (R)^8d)-。

Item 22: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein Y is a group-O-.

Item 23: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein Y is a group-N (R)⁵)-。

Item 24: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein Y is a group-CO-, a group-ch (OH) -, a lower alkylene group, a group-s (o) N-, or a group-C (═ N-OH) -.

Item 25: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein A is

[ general formula 49]

A group of (1).

Item 26: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein A is

[ general formula 50]

A group of (1).

Item 27: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is⁴Represents imidazolyl lower alkyl, 1, 2, 4-triazolyl lower alkyl, 1, 2, 3-triazolyl lower alkyl, 1, 2, 5-triazolyl lower alkyl, pyrazolyl lower alkyl, pyrimidinyl lower alkyl which may have an oxy group as a substituent on the pyrimidine ring, 3, 5-dioxoisoxazolidin-4-ylidene lower alkyl, 1, 2, 4-oxadiazolyl lower alkyl which may have a lower alkyl group as a substituent on the 1, 2, 4-oxadiazolyl ring, thiazolidinyl lower alkyl which may have an oxy group as a substituent on the thiazolidine ring, a substituted lower alkyl group, a,

[ general formula 51]

Group of (A) or

[ general formula 52]

A group of (1).

Item 28: the aromatic compound or a salt thereof according to any one of claims 1 to 21, which is represented by the general formula (1), wherein R⁴Represents a group- (T)_l-N(R¹⁴)R¹⁵(T、R¹⁴And R¹⁵Same as defined above) and l represents 0.

Item 29: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is⁴Is a group- (T)_l-N(R¹⁴)R¹⁵And l is 1.

Item 30: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a group-N (R)¹⁷)-B₃-CO-。

Item 31: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a radical-B₁₉-N(R¹⁸)-CO-。

Item 32: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a radical-B₄-CO-。

Item 33: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a group-Q-B₅-CO-。

Item 34: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a radical-B₆-N(R¹⁹)-B₇-。

Item 35: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a radical-CO-B₈-。

Item 36: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a group-CH (OH) -B₉-。

Item 37: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is ⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a radical-CO-B₁₀-CO-。

Item 38: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a group-CH (OH) -B₁₁-CO-。

Item 39: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a group-CO-.

Item 40: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a group-SO₂-。

Item 41: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a radical-B_23a-CO-CO-。

Item 42: the aromatic compound or a salt thereof according to any one of claims 1 to 21, wherein R is⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is lower alkylene.

Item 43: the aromatic compound or a salt thereof according to claim 1, which comprises, as an active ingredient, a compound selected from the group consisting of compounds represented by the general formulae (1-1), (1-2), (1-8), (1-9), (1-15), (1-16), (1-29), (1-30), (1-43), (1-44), (1-57), (1-58), (1-64) and (1-65) or a salt thereof, wherein Y is a group-O-or a group-N (R) ⁵) -, A is

[ general formula 53]

A group of (A), and

R⁴is a group- (T)_l-N(R¹⁴)R¹⁵。

Item 44: the aromatic compound or a salt thereof according to item 43, wherein l is 1, and T is a group-N (R)¹⁷)-B₃-CO-。

Item 45: the aromatic compound or a salt thereof according to item 43, wherein l is 1, and T is a group-B₄-CO-。

Item 46: the aromatic compound or a salt thereof according to item 43, wherein l is 1, and T is a group-CO-.

Item 47: the aromatic compound or a salt thereof according to item 43, wherein l is 0.

Item 48: the aromatic compound or a salt thereof according to item 1, which comprises a compound selected from the following compounds or a salt thereof as an active ingredient:

n- [6- (4- { [2- (4-Piperazinylpiperazin-1-yl) -2-oxoethyl ] ethylamino } -2-methoxyphenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide

(N-[6-(4-{[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]ethylamino}-2-methoxyphenoxy)pyridin-3-yl]-3，4-dichlorobenzamide)、

N- [6- (4- { [2- (4-Piperazino-1-yl) -2-oxoethyl ] ethylamino } phenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide

(N-[6-(4-{[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]ethylamino}phenoxy)pyridin-3-yl]-4-trifluoromethylbenzamide)、

N- [6- (4- { [2- (4-Piperazino-1-yl) -2-oxoethyl ] ethylamino } -2-fluorophenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide

N-[6-(4-{[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]ethylamino}-2-fluorophenoxy)pyridin-3-yl]-4-trifluoromethylbenzamide、

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] methylamino } -2-fluorophenoxy) pyridin-3-yl-4-trifluoromethylbenzamide

(N-[6-(4-{[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]methylamino}-2-fluorophenoxy)pyridin-3-yl]-4-trifluoromethylbenzamide)、

N- [6- (4- { [2- (4-Piperazino-1-yl) -2-oxoethyl ] methylamino } -2-methoxyphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide

(N-[6-(4-{[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]methylamino}-2-methoxyphenoxy)pyridin-3-yl]-4-trifluoromethylbenzamide)、

N- [6- (4- { [2- (4-Piperazino-1-yl) -2-oxoethyl ] ethylamino } -2-methoxyphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide

(N-[6-(4-{[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]ethylamino}-2-methoxyphenoxy)pyridin-3-yl]-4-trifluoromethylbenzamide)、

N- [6- (4- { [2- (4-Piperazinylpiperazin-1-yl) -2-oxoethyl ] ethylamino } -2-methylphenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide

(N-[6-(4-{[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]ethylamino}-2-methylphenoxy)pyridin-3-yl]-3，4-dichlorobenzamide)、

N- [6- (4- { [2- (4-Piperazino-1-yl) -2-oxoethyl ] methylamino } -2-methylphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide

(N-[6-(4-{[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]methylamino}-2-methylphenoxy)pyridin-3-yl]-4-trifluoromethylbenzamide)、

N- (6- {4- [3- (4-Piperazino-1-yl) -3-oxopropyl ] phenoxy } pyridin-3-yl) -3, 4-dichlorobenzenesulfonamide

(N-(6-{4-[3-(4-piperonylpiperazin-1-yl)-3-oxopropyl]phenoxy}pyridin-3-yl)-3，4-dichlorobenzenesulfonamide)、

N- [6- (4- {4- [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] piperazin-1-yl } phenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide

(N-[6-(4-{4-[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]piperazin-1-yl}phenoxy)pyridin-3-yl]-4-trifluoromethylbenzamide)、

N- [6- (4- {4- [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } phenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide

(N-[6-(4-{4-[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]piperidin-1-yl}phenoxy)pyridin-3-yl]-4-trifluoromethylbenzamide)、

N- {6- [ (4- {4- [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } phenyl) methylamino ] pyridin-3-yl } -4-trifluoromethylbenzamide

(N-{6-[(4-{4-[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]piperidin-1-yl}phenyl)methylamino]pyridin-3-yl}-4-trifluoromethylbenzamide)、

N- [6- (4- {4- [2- (4-Benzylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } -2-methylphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide

(N-[6-(4-{4-[2-(4-benzylpiperazin-1-yl)-2-oxoethyl]piperidin-1-yl}-2-methylphenoxy)pyridin-3-yl]-4-trifluoromethylbenzamide)、

N- [6- (4- {4- [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } -2-methylphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide

(N-[6-(4-{4-[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]piperidin-1-yl}-2-methylphenoxy)pyridin-3-yl]-4-trifluoromethylbenzamide)、

N- [6- (4- {4- [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } -2-methylphenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide

(N-[6-(4-{4-[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]piperidin-1-yl}-2-methylphenoxy)pyridin-3-yl]-3，4-dichlorobenzamide)、

N- {6- [4- (4-benzylpiperazine-1-carbonyl) phenoxy ] pyridin-3-yl } -4-trifluoromethylbenzamide

(N-{6-[4-(4-benzylpiperazine-1-carbonyl)phenoxy]pyridin-3-yl}-4-trifluoromethylbenzamide)、

N- {6- [4- (4-benzylpiperazine-1-carbonyl) phenoxy ] pyridin-3-yl } -3, 4-dichlorobenzamide

(N-{6-[4-(4-benzylpiperazine-1-carbonyl)phenoxy]pyridin-3-yl}-3，4-dichlorobenzamide)、

N- [6- ({4- [3- (4-Piperazino-1-yl) -3-oxopropyl ] phenyl } methylamino) pyridin-3-yl ] -4-trifluoromethylbenzamide

(N-[6-({4-[3-(4-piperonylpiperazin-1-yl)-3-oxopropyl]phenyl}methylamino)pyridin-3-yl]-4-trifluoromethylbenzamide)、

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] ethylamino } -2-fluorophenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide

(N-[6-(4-{[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]ethylamino}-2-fluorophenoxy)pyridin-3-yl]-3，4-dichlorobenzamide)、

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] methylamino } -2-fluorophenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide

(N-[6-(4-{[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]methylamino}-2-fluorophenoxy)pyridin-3-yl]-3，4-dichlorobenzamide)、

N- [6- (4- { [2- (4-Piperazino-1-yl) -2-oxoethyl ] methylamino } -2-methoxyphenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide

(N-[6-(4-{[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]methylamino}-2-methoxyphenoxy)pyridin-3-yl]-3，4-dichlorobenzamide)、

N- [6- (4- { [2- (4-Piperazino-1-yl) -2-oxoethyl ] methylamino } phenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide

(N-[6-(4-{[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]methylamino}phenoxy)pyridin-3-yl]-3，4-dichlorobenzamide)、

1- (6- {4- [3- (4-Piperazinylpiperazin-1-yl) -3-oxopropyl ] phenoxy } pyridin-3-yl) -3- (3, 4-dichlorophenyl) -1-ethylurea

(1-(6-{4-[3-(4-piperonylpiperazin-1-yl)-3-oxopropyl]phenoxy}pyridin-3-yl)-3-(3，4-dichlorophenyl)-1-ethylurea)、

N- (6- {4- [3- (4-Piperazino-1-yl) -3-oxopropyl ] phenoxy } pyridin-3-yl) -4-trifluoromethylbenzamide

(N-(6-{4-[3-(4-piperonylpiperazin-1-yl)-3-oxopropyl]phenoxy}pyridin-3-yl)-4-trifluoromethylbenzamide)、

N- [6- (4- { [2- (4-Benzylpiperazin-1-yl) -2-oxoethyl ] methylamino } -2-methylphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide

(N-[6-(4-{[2-(4-benzylpiperazin-1-yl)-2-oxoethyl]methylamino}-2-methylphenoxy)pyridin-3-yl]-4-trifluoromethylbenzamide)、

N- [6- (4- {4- [2- (4-benzylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } phenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide

(N-[6-(4-{4-[2-(4-benzylpiperazin-1-yl)-2-oxoethyl]piperidin-1-yl}phenoxy)pyridin-3-yl]-3，4-dichlorobenzamide)、

N- (6- {4- [3- (4-Piperazinylpiperazine-1-carbonyl) piperidin-1-yl ] phenoxy } pyridin-3-yl) -3, 4-dichlorobenzamide

(N-(6-{4-[3-(4-piperonylpiperazine-1-carbonyl)piperidin-1-yl]phenoxy}pyridin-3-yl)-3，4-dichlorobenzamide)、

N- [6- (4- {4- [2- (4-Benzylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } phenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide

(N-[6-(4-{4-[2-(4-benzylrupiperazin-1-yl)-2-oxoethyl]piperidin-1-yl}phenoxy)pyridin-3-yl]-4-trifluoromethylbenzamide)、

N- {6- [ (4- {4- [2- (4-benzylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } phenyl) methylamino ] pyridin-3-yl } -4-trifluoromethylbenzamide

(N-{6-[(4-{4-[2-(4-benzylpiperazin-1-yl)-2-oxoethyl]piperidin-1-yl}phenyl)methylamino]pyridin-3-yl}-4-trifluoromethylbenzamide)、

N- (6- {4- [ (2- {4- [4- (4-fluorobenzoyl) phenyl ] piperazin-1-yl } -2-oxoethyl) methylamino ] -2-methoxyphenoxy } pyridin-3-yl) -4-trifluoromethylbenzamide

(N-(6-{4-[(2-{4-[4-(4-fluorobenzoyl)phenyl]piperazin-1-yl}-2-oxoethyl)methylamino]-2-methoxyphenoxy}pyridin-3-yl)-4-trifluoromethylbenzamide)、

2- (4-Piperazino-piperazin-1-yl) -N- { 3-methyl-4- [5- (4-trifluoromethylphenoxymethyl) pyridin-2-yloxy ] phenyl } -2-oxoacetamide

(2-(4-piperonylpiperazin-1-yl)-N-{3-methyl-4-[5-(4-trifluoromethylphenoxymethyl)pyridin-2-yloxy]phenyl}-2-oxoacetamide)、

N- [6- (4- { [2- (4-Piperazino-1-yl) -2-oxoethyl ] methylamino } -2-methylphenoxy) pyridin-3-yl ] -2-fluoro-4-trifluoromethylbenzamide

(N-[6-(4-{[2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]methylamino}-2-methylphenoxy)pyridin-3-yl]-2-fluoro-4-trifluoromethylbenzamide)、

N- [6- (4- {4- [2- (4-Piperazino-1-yl) -2-oxoethyl ] piperidin-1-yl } -2-methoxyphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide

(N- [6- (4- {4- [2- (4-piperidinylpiperazin-1-yl) -2-oxoethyl ] perindin-1-yl } -2-methoxyphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide) and

4- (3- { 3-methyl-4- [5- (4-trifluoromethylbenzoylamino) pyridin-2-yloxy ] phenyl } -2-oxohexahydropyrimidin-1-yl) benzoic acid ethyl ester

(4-(3-{3-methyl-4-[5-(4-trifluoromethylbenzoylamino)pyridin-2-yloxy]phenyl}-2-oxohexahydropyrimidin-1-yl)benzoic acid ethyl ester)。

The aromatic compound or a salt thereof used as the active ingredient of the present invention is a known compound and is described in patent document 1.

Specific examples of the respective groups shown in the general formula (1) are as follows:

examples of the lower alkenylene group include linear or branched alkenylene groups having 2 to 6 carbon atoms and 1 to 3 double bonds, such as vinylene, 1-propenylene, 1-methyl-1-propenylene, 2-butenylene, 1-butenylene, 3-butenylene, 2-pentenylene, 1-pentenylene, 3-pentenylene, 4-pentenylene, 1, 3-butadienylene, 1, 3-pentadienylene, 2-penten-4-ylene, 2-hexenylene, 1-hexenylene, 5-hexenylene, 3-hexenylene, 4-hexenylene, 3-dimethyl-1-propenylene, 2-pentenylene, 2-hexenylene, 1-hexenylene, 3-pentenylene, 3-dimethyl-1-propenylene, 2-ethyl-1-propenylene, 1, 3, 5-hexatrienylene, 1, 3-hexadieneylene and 1, 4-hexadiene.

Examples of the lower alkynylene group include a straight chain or branched alkynylene group having 2 to 6 carbon atoms and 1 to 3 triple bonds, for example, ethynylene, 1-propynyl, 1-methyl-1-propynyl, 2-butynyl, 1-butynyl, 3-butynyl, 2-pentynyl, 1-pentynyl, 3-pentynyl, 4-pentynyl, 2-hexynyl, 1-hexynyl, 5-hexynyl, 3-hexynyl, 4-hexynyl, 3-diethyl-1-propynyl and 2-ethyl-1-propynyl.

Examples of the lower alkoxy group include straight or branched alkoxy groups having 1 to 6 carbon atoms such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, tert-butoxy, pentyloxy and hexyloxy.

Examples of the lower alkyl group include straight or branched alkyl groups having 1 to 6 carbon atoms, such as methyl, ethyl, propyl, isopropyl, 2-dimethylpropyl, 1-ethylpropyl, butyl, isobutyl, tert-butyl, isopentyl, pentyl and hexyl.

Examples of the lower alkyl group which may have a lower alkoxy group as a substituent include, in addition to the above-mentioned lower alkyl group, a linear or branched alkyl group of 1 to 6 carbon atoms which may have a linear or branched alkoxy group containing 1 to 6 carbon atoms as a substituent, such as methoxymethyl group, 1-ethoxyethyl group, 2-methoxyethyl group, 2-propoxyethyl group, 3-isopropoxypropyl group, 4-butoxybutyl group, 5-pentyloxypentyl group, 6-hexyloxyhexyl group, 1-dimethyl-2-methoxyethyl group, 2-methyl-3-ethoxypropyl group and 3-methoxypropyl group.

Examples of the lower alkanoyl group include straight-chain or branched alkanoyl groups having 1 to 6 carbon atoms, such as formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, t-butylacyl and hexanoyl.

Examples of the phenyl lower alkyl group include phenylalkyl groups whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as benzyl, 2-phenylethyl, 1-phenylethyl, 3-phenylpropyl, 4-phenylbutyl, 5-phenylpentyl, 6-phenylhexyl, 1-dimethyl-2-phenylethyl and 2-methyl-3-phenylpropyl.

Examples of the lower alkylene group include linear or branched alkylene groups having 1 to 6 carbon atoms, such as a methylene group, an ethylene group, a trimethylene group, a 2-methyltrimethylene group, a 2, 2-dimethylethylene group, a 2, 2-dimethyltrimethylene group, a 1-methyltrimethylene group, a methylmethylene group, an ethylmethylene group, a tetramethylene group, a pentamethylene group and a hexamethylene group.

Examples of the lower alkenylene group which may have a phenyl group as a substituent include straight-chain or branched alkenylene groups having 2 to 6 carbon atoms and 1 to 3 double bonds and which may have a phenyl group as a substituent, such as vinylene group, 1-propenylene group, 1-methyl-1-propenylene group, 2-butenylene group, 1-butenylene group, 3-butenylene group, 2-pentenylene group, 1-pentenylene group, 3-pentenylene group, 4-pentenylene group, 1, 3-butadienylene group, 1, 3-pentadienylene group, 2-penten-4-ylene group, 2-hexenylene group, 1-hexenylene group, 5-hexenylene group, 3-hexenylene group, 4-hexenylene group, 3-dimethyl-1-propenylene group, 2-ethyl-1-propenylene group, 1, 3, 5-hexatrienylene group, 1, 3-hexadieneylene group, 1, 4-hexadieneylene group, 1-phenylvinylene group, 3-phenyl-1-propenylene group, 3-phenyl-1-methyl-1-propenylene group, 3-phenyl-2-methyl-1-propenylene group, 1-phenyl-2-butenylene group, 3-phenyl-1-butenylene group, 1-phenyl-3-butenylene group, 5-phenyl-2-pentenylene group, 4-phenyl-1-pentenyl group, 2-phenyl-3-pentenyl group, 1-phenyl-4-pentenyl group, 1-phenyl-1, 3-butadienyl group, 1-phenyl-1, 3-pentadienyl group, 1-phenyl-2-penten-4-yl group, 1-phenyl-2-hexenyl group, 3-phenyl-1-hexenyl group, 4-phenyl-5-hexenyl group, 6-phenyl-3-hexenyl group, 5-phenyl-4-hexenyl group, 1-phenyl-3, 3-dimethyl-1-propenyl group, 1-phenyl-2-ethyl-1-propenyl group, 6-phenyl-1, 3, 5-hexatrienylene, 1-phenyl-1, 3-hexadienylene and 2-phenyl-1, 4-hexadienylene.

Examples of the lower alkylene group which may be substituted with a group selected from the group consisting of a lower alkoxy group and a phenyl group include, in addition to the above-mentioned lower alkylene groups, straight-chain or branched alkylene groups having 1 to 6 carbon atoms which may be substituted with 1 or 2 groups selected from the group consisting of a straight-chain or branched alkoxy group having 1 to 6 carbon atoms and a phenyl group, for example, methoxymethylene group, 2-phenylethenyl group, 3-ethoxytrimethylene group, 1-propoxy-2-methyltrimethylene group, 1-phenyl-2, 2-dimethylethylene group, 3-phenyl-2, 2-dimethyltrimethylene group, 2-butoxy-1-methyltrimethylene group, phenylmethylmethylene group, 2-pentoxyethylmethylene group, 4-phenyl-2-hexoxytetramethylene group, 3-phenylpentamethylene, 5-phenylhexamethylene, ethoxymethylene, 1-phenylethylene, 3-phenyltrimethylene and 2-phenyl-1-methoxyethylene.

Examples of the 5-to 15-membered monocyclic, bicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms include pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, pyridinyl, 1, 2, 5, 6-tetrahydropyridinyl, 1, 2, 4-triazolyl, 1, 2, 3-triazolyl, 1, 2, 5-triazolyl, thiazolidinyl, 1, 2, 3, 4-tetrazolyl, thienyl, quinolyl, 1, 4-dihydroquinolyl, benzothiazolyl, pyrazinyl, pyrimidinyl, pyridazinyl, 2H-pyrrolyl, 1, 3, 4-oxadiazolyl, tetrahydropyranyl, tetrahydrofuranyl, furonyl (furazanyl), quinolonyl (carbostyryl), 3, 4-dihydroquinolonyl, 1, 2, 3, 4-tetrahydroquinolyl, quinolonyl, quinolyl, and the like, 1, 2, 3, 4-tetrahydroisoquinolinyl, indolyl, isoindolyl, indolinyl (indolinyl), benzimidazolyl, benzoxazolyl, imidazolidinyl, isoquinolyl, quinazolinyl, quinoxalinyl, cinnolinyl, 2, 3-naphthyridinyl, carbazolyl, acridinyl, chromanyl, isoindolinyl, isobenzodihydropyranyl, pyrazolyl, imidazolyl, pyrazolidinyl, phenothiazinyl, benzofuranyl, 2, 3-dihydrobenzo [ b ] furanyl, benzothienyl, phenoxathiinyl, phenoxazinyl, 4H-chromanyl (4H-chromenyl), 1H-indazolyl, phenazinyl, xanthenyl, thianthrenyl, 2-imidazolinyl, 2-pyrrolinyl, furanyl, oxazolyl, isoxazolyl, cinnolinyl (indolinyl), cinnolinyl, quinoxalinyl, cinnolinyl, carbazolyl, cinnolin, Isoxazolyl, thiazolyl, isothiazolyl, pyranyl, 2-thiazolinyl, 2-pyrazolinyl, quinuclidinyl, 1, 4-benzoxazinyl (1, 4-benzoxadinyl), 3, 4-dihydro-2H-1, 4-benzoxazinyl (3, 4-dihydro-2H-1, 4-benzoxadinyl), 3, 4-dihydro-2H-1, 4-benzothiazinyl, 1, 2, 3, 4-tetrahydroquinoxalinyl, 1, 3-dithia-2, 4-dihydronaphthyl, phenanthridinyl, 1, 4-dithianyl, dibenzo [ b, e ] azepinyl and 6, 11-dihydro-5H-dibenzo [ b, e ] azepinyl.

Examples of the halogen atom include a fluorine atom, a chlorine atom, a bromine atom and an iodine atom.

Examples of the lower alkoxy group which may have a halogen atom as a substituent include straight-chain or branched alkoxy groups having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as substituents, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, tert-butoxy, pentyloxy, hexyloxy, trifluoromethoxy, trichloromethoxy, chloromethoxy, bromomethoxy, fluoromethoxy, iodomethoxy, difluoromethoxy, dibromomethoxy, 2-chloroethoxy, 2, 2, 2-trifluoroethoxy, 2, 2, 2-trichloroethoxy, 3-chloropropoxy, 2, 3-dichloropropoxy, 4, 4, 4-trichlorobutoxy, 4-fluorobutoxy, 5-chloropentyloxy, 3-chloro-2-methylpropoxy, 6-bromohexyloxy and 5, 6-dichlorohexyloxy.

Examples of the lower alkyl group which may have a halogen atom as a substituent include, in addition to the above-mentioned lower alkyl groups, straight-chain or branched alkyl groups having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as substituents, such as trifluoromethyl, trichloromethyl, chloromethyl, bromomethyl, fluoromethyl, iodomethyl, difluoromethyl, dibromomethyl, dichloromethyl, 2-chloroethyl, 2, 2, 2-trifluoroethyl, 2, 2, 2-trichloroethyl, 3-chloropropyl, 2, 3-dichloropropyl, 4, 4, 4-trichlorobutyl, 4-fluorobutyl, 5-chloropentyl, 3-chloro-2-methylpropyl, 5-bromohexyl and 5, 6-dibromohexyl.

Examples of the lower alkylsulfonyl group include straight or branched alkylsulfonyl groups having 1 to 6 carbon atoms, such as methylsulfonyl group, ethylsulfonyl group, propylsulfonyl group, isopropylsulfonyl group, butylsulfonyl group, t-butylsulfonyl group, pentylsulfonyl group and hexylsulfonyl group.

Examples of the phenyl group which may be substituted on the benzene ring with a lower alkyl group which may have a halogen atom include phenyl groups which may be substituted on the benzene ring with 1 to 3 linear or branched alkyl groups having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms, such as phenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2-ethylphenyl, 3-ethylphenyl, 4-isopropylphenyl, 3-butylphenyl, 4-pentylphenyl, 4-hexylphenyl, 3, 4-dimethylphenyl, 3, 4-diethylphenyl, 2, 4-dimethylphenyl, 2, 5-dimethylphenyl, 2, 6-dimethylphenyl, 3, 4, 5-trimethylphenyl, 2-trifluoromethylphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl group, 2- (bromomethyl) phenyl group, 3- (2-chloroethyl) phenyl group, 4- (2, 3-dichloropropyl) phenyl group, 4- (4-fluorobutyl) phenyl group, 3- (5-chloropentyl) phenyl group, 4- (5-bromohexyl) phenyl group, 4- (5, 6-dibromohexyl) phenyl group, 3, 4-bis (trifluoromethyl) phenyl group, 3, 4-bis (4, 4, 4-trichlorobutyl) phenyl group, 2, 4-bis (3-chloro-2-methylpropyl) phenyl group, 2, 5-bis (3-chloropropyl) phenyl group, 2, 6-bis (2, 2, 2-trifluoroethyl) phenyl group, 3, 4, 5-tris (trifluoromethyl) phenyl group, 4- (2, 2, 2-trichloroethyl) phenyl, 2-methyl-4-trifluoromethylphenyl and 3-ethyl-4-trichloromethylphenyl.

Examples of the lower alkylthio group include straight or branched alkylthio groups having 1 to 6 carbon atoms, such as methylthio, ethylthio, propylthio, isopropylthio, butylthio, tert-butylthio, pentylthio and hexylthio.

Examples of the amino group which may have a group selected from the group consisting of a lower alkyl group and a lower alkanoyl group as a substituent include amino groups which may have 1 or 2 groups selected from the group consisting of a linear or branched alkyl group having 1 to 6 carbon atoms and a linear or branched alkanoyl group having 1 to 6 carbon atoms as substituents, such as amino, methylamino, ethylamino, propylamino, isopropylamino, butylamino, tert-butylamino, pentylamino, hexylamino, dimethylamino, diethylamino, dipropylamino, dibutylamino, dipentylamino, dihexylamino, N-methyl-N-ethylamino, N-ethyl-N-propylamino, N-methyl-N-butylamino, N-methyl-N-hexylamino, N-acetylamino, N-formylamino, N-propionylamino, N-butyrylamino, N-isobutyrylamino, N-pentanoylamino, N-tert-butanoylamino, N-hexanoylamino, diacetylamino, N-acetyl-N-methylamino and N-acetyl-N-ethylamino.

Examples of the naphthyl group which may be substituted on the naphthalene ring with 1 to 3 substituents selected from the group consisting of a lower alkyl group, a halogen atom and an amino group which may have a group selected from the group consisting of a lower alkyl group and a lower alkanoyl group include naphthyl groups which may have 1 to 3 substituents selected from the group consisting of a straight-chain or branched alkyl group having 1 to 6 carbon atoms, a halogen atom and an amino group which may have 1 or 2 substituents selected from the group consisting of a straight-chain or branched alkyl group having 1 to 6 carbon atoms and a straight-chain or branched alkanoyl group having 1 to 6 carbon atoms on the naphthalene ring, such as (1-or 2-) naphthyl group, 1-methyl- (2-, 3-, 4-, 5-, 6-, 7-or 8-) naphthyl group, 2-ethyl- (1-, 3-, 4-, 5-, 6-, 7-or 8-) naphthyl group, 1-methyl- (3-, 4-, 5-, 6-, 7-or, 3-n-propyl- (1-, 2-, 4-, 5-, 6-, 7-or 8-) naphthyl, 4-n-butyl- (1-, 2-, 3-, 5-, 6-, 7-or 8-) naphthyl, 4-methyl- (1-, 2-, 3-, 5-, 6-, 7-or 8-) naphthyl, 5-n-pentyl- (1-, 2-, 3-, 4-, 6-, 7-or 8-) naphthyl, 6-n-hexyl- (1-, 2-, 3-, 4-, 5-, 7-or 8-) naphthyl, 1, 7-dimethyl- (2-, 3-, 4-, 5-, 6-or 8-) naphthyl, 1, 2, 8-trimethyl- (3-, 4-, 5-, 6-or 7-) naphthyl, 1-dimethylamino- (2-, 3-, 4-, 5-, 6-, 7-or 8-) naphthyl, 2-dimethylamino- (1-, 3-, 4-, 5-, 6-, 7-or 8-) naphthyl, 3-methylamino- (1-, 2-, 4-, 5-, 6-, 7-or 8-) naphthyl, 5-amino- (1-, 2-, 3-, 4-, 6-, 7-or 8-) naphthyl, m, 5-dimethylamino- (1-, 2-, 3-, 4-, 6-, 7-or 8-) naphthyl, 4- (N-methyl-N-ethylamino) - (1-, 2-, 3-, 5-, 6-, 7-or 8-) naphthyl, 1-methyl-2-dimethylamino- (3-, 4-, 5-, 6-, 7-or 8-) naphthyl, 1-chloro- (2-, 3-, 4-, 5-, 6-, 7-or 8-) naphthyl and 1-acetamido- (2-, 3-, 4-, 5-, 6-, 7-or 8-) naphthyl.

Examples of the alkyl group which may have a lower alkoxy group as a substituent include, in addition to the above-mentioned lower alkyl group which may have a lower alkoxy group as a substituent, a straight-chain or branched alkyl group having 1 to 8 carbon atoms which may have a straight-chain or branched alkoxy group having 1 to 6 carbon atoms as a substituent, such as a heptyl group, a 1-ethylpentyl group, an octyl group, a 7-methoxyheptyl group, a 1-ethoxyheptyl group, a 2-propoxy-1-ethylpentyl group, a 3-isopropoxyoctyl group, a 7-butoxyheptyl group, an 8-pentoxyoctyl group and a 5-hexyloxy-1-ethylpentyl group.

Examples of the lower alkyl group which may have a lower alkyl group and which may have an amino substitution include a straight chain or branched alkyl group having 1 to 6 carbon atoms which may be substituted with an amino group having 1 or 2 straight chain or branched alkyl groups having 1 to 6 carbon atoms, such as aminomethyl, 2-aminoethyl, 1-aminoethyl, 3-aminopropyl, 4-aminobutyl, 5-aminopentyl, 6-aminohexyl, 1-dimethyl-2-aminoethyl, 2-methyl-3-aminopropyl, methylaminomethyl, 1-ethylaminoethyl, 2-propylaminoethyl, 3-isopropylaminopropyl, 4-butylaminobutyl, 5-pentylaminopentyl, 6-hexylaminohexyl, dimethylaminomethyl, 2-diethylaminoethyl, 2-diisopropylaminoethyl, (N-ethyl-N-propylamino) methyl group and 2- (N-methyl-N-hexylamino) ethyl group.

Examples of the cycloalkyl group include cycloalkyl groups having 3 to 16 carbon atoms, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclodecyl, cycloundecyl, cyclododecyl, cyclotridecyl, cyclotetradecyl, cyclopentadecyl and cyclohexadecyl.

Examples of the cycloalkyl group which may be substituted on the cycloalkyl ring with a group selected from a lower alkyl group which may be substituted with an amino group which may have a lower alkyl group and a lower alkyl group which may have a halogen atom as a substituent include, in addition to the above-mentioned cycloalkyl groups, cycloalkyl groups having 3 to 16 carbon atoms which may be substituted with 1 to 3 groups selected from a straight-chain or branched alkyl group having 1 to 6 carbon atoms which may be substituted with an amino group having 1 or 2 straight-chain or branched alkyl groups having 1 to 6 carbon atoms and a straight-chain or branched alkyl group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent, such as 4-dimethylaminomethylcyclohexyl, 2- (aminomethyl) cyclopropyl, 3- (2-aminomethyl) cyclobutyl, 2- (1-aminoethyl) cyclopentyl, 3- (3-aminopropyl) cyclohexyl, 3- (4-aminobutyl) cycloheptyl group, 4- (5-aminopentyl) cyclooctyl group, 4- (6-aminohexyl) cyclohexyl group, 2- (1, 1-dimethyl-2-aminoethyl) cycloheptyl group, 3- (2-methyl-3-aminopropyl) cyclopentyl group, 3- (methylaminomethyl) cyclohexyl group, 2- (1-ethylaminoethyl) cyclooctyl group, 2- (2-propylaminoethyl) cyclohexyl group, 3- (3-isopropylaminopropyl) cyclopentyl group, 4- (4-butylaminobutyl) cycloheptyl group, 2- (5-pentylaminopentyl) cyclohexyl group, 2- (6-hexylaminohexyl) cyclopentyl group, 3- (dimethylaminomethyl) cyclohexyl group, cyclohexyl group, 3- [ (N-Ethyl-N-propylamino) methyl ] cycloheptyl, 4- [2- (N-methyl-N-hexylamino) ethyl ] cyclooctyl, 4-dimethylaminomethylcyclononyl, 2- (aminomethyl) cyclodecyl, 3- (2-aminomethyl) cycloundecyl, 2- (1-aminoethyl) cyclododecyl, 3- (3-aminopropyl) cyclotridecyl, 3- (4-aminobutyl) cyclotetradecyl, 4- (5-aminopentyl) cyclopentadecyl, 4- (6-aminohexyl) cyclohexadecyl, 2- (1, 1-dimethyl-2-aminoethyl) cyclononyl, 3- (2-methyl-3-aminopropyl) cyclodecyl, N-ethyl-N-methyl-N-hexylamino-2-aminoethyl-cyclononyl, N-ethylmethyl-N-1-aminopropyl-cyclodecyl, N-ethylcyclohexyl-2-aminodecyl, N-ethyl, 3- (methylaminomethyl) cycloundecyl, 2- (1-ethylaminoethyl) cyclododecyl, 2- (2-propylaminoethyl) cyclotridecyl, 3- (3-isopropylaminopropyl) cyclotetradecyl, 4- (4-butylaminobutyl) cyclopentadecyl, 2- (5-pentylaminopentyl) cyclohexadecyl, 2- (6-hexylaminohexyl) cyclononyl, 3- (dimethylaminomethyl) cyclododecyl, 3- [ (N-ethyl-N-propylamino) methyl ] cyclodecyl, 4- [2- (N-methyl-N-hexylamino) ethyl ] cyclohexadecyl, 2-dimethylcyclopropyl and 2-trifluoromethylcyclopropyl.

Examples of the lower alkenyl group include straight-chain or branched alkenyl groups having 2 to 6 carbon atoms and 1 to 3 double bonds, such as vinyl, 1-propenyl, 1-methyl-1-propenyl, 2-butenyl, 1-butenyl, 3-butenyl, 2-pentenyl, 1-pentenyl, 3-pentenyl, 4-pentenyl, 1, 3-butadienyl, 1, 3-pentadienyl, 2-penten-4-yl, 2-hexenyl, 1-hexenyl, 5-hexenyl, 3-hexenyl, 4-hexenyl, 3-dimethyl-1-propenyl, 2-ethyl-1-propenyl, 2-hexenyl, 1, 3, 5-hexanetriene, 1, 3-hexadienyl and 1, 4-hexadienyl.

Examples of the lower alkenyl group which may have a halogen atom as a substituent include, in addition to the above-mentioned lower alkenyl groups, straight-chain or branched alkenyl groups having 2 to 6 carbon atoms and 1 to 3 double bonds which may have 1 to 3 halogen atoms as substituents, such as 3, 3, 3-trifluoro-1-propenyl, 2-bromovinyl, 3-chloro-1-propenyl, 3-iodo-1-methyl-1-propenyl, 3-fluoro-2-methyl-1-propenyl, 2-butenyl, 4, 3-trichloro-1-butenyl, 4-difluoro-3-butenyl, 5-fluoro-2-pentenyl, 5, 3-tribromo-1-pentenyl, 5-bromo-1-pentenyl, 3-chloro-1-propenyl, 3-iodo-1-methyl-1-propenyl, 3-fluoro-2-pentenyl, 3-bromo, 5-chloro-3-pentenyl, 5, 5, 5-trifluoro-4-pentenyl, 4-chloro-1, 3-butadienyl, 5-fluoro-1, 3-pentadienyl, 5-bromo-2-penten-4-yl, 6-fluoro-2-hexenyl, 6, 5-trifluoro-1-hexenyl, 6-chloro-5-hexenyl, 5-bromo-3-hexenyl, 6-chloro-4-hexenyl, 3-dimethyl-2-chloro-1-propenyl, 3-fluoro-2-ethyl-1-propenyl, 6-chloro-1, 3, 5-hexanetrienyl, 5-trifluoro-pentenyl, 5-chloro-2-hexenyl, 6-bromo-hexenyl, 6-chloro-4-hexenyl, 3-dimethyl-2-chloro-1-propenyl, 3-fluoro, 6-bromo-1, 3-hexadienyl and 6-fluoro-1, 4-hexadienyl.

Examples of the benzoyl group (which may have 1 to 3 substituents selected from the group consisting of a lower alkyl group which may have a halogen atom as a substituent and a halogen atom on the benzene ring) include benzoyl groups (which may have 1 to 3 substituents selected from the group consisting of a linear or branched alkyl group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent and a halogen atom on the benzene ring), such as benzoyl group, 3, 4-difluorobenzoyl group, 2-fluorobenzoyl group, 3-bromobenzoyl group, 4-iodobenzoyl group, 4-methylbenzoyl group, 2-methylbenzoyl group, 3-methylbenzoyl group, 2-ethylbenzoyl group, 3-ethylbenzoyl group, 4-isopropylbenzoyl group, 3-butylbenzoyl group, 4-pentylbenzoyl, 4-hexylbenzoyl, 3, 4-dimethylbenzoyl, 3, 4-diethylbenzoyl, 2, 4-dimethylbenzoyl, 2, 5-dimethylbenzoyl, 2, 6-dimethylbenzoyl, 3, 4, 5-trimethylbenzoyl, 2-trifluoromethylbenzoyl, 3-trifluoromethylbenzoyl, 4-trifluoromethylbenzoyl, 2- (bromomethyl) benzoyl, 3- (2-chloroethyl) benzoyl, 4- (2, 3-dichloropropyl) benzoyl, 4- (4-fluorobutyl) benzoyl, 3- (5-chloropentyl) benzoyl, 4- (5-bromohexyl) benzoyl, 4- (5, 6-dibromohexyl) benzoyl, 3, 4-bis (trifluoromethyl) benzoyl, 3, 4-bis (4, 4, 4-trichlorobutyl) benzoyl, 2, 4-bis (3-chloro-2-methylpropyl) benzoyl, 2, 5-bis (3-chloropropyl) benzoyl, 2, 6-bis (2, 2, 2-trifluoroethyl) benzoyl, 3, 4, 5-tris (trifluoromethyl) benzoyl, 4- (2, 2, 2-trichloroethyl) benzoyl, 2-methyl-4-trifluoromethylbenzoyl, 3-ethyl-4-trichloromethylbenzoyl, 2-chloro-4-trifluoromethylbenzoyl, 3-ethyl-4-fluorobenzoyl, 3-methyl-4-fluorobenzoyl, methyl-4-trifluoromethyl-benzoyl, methyl-2, methyl-4-methyl-benzoyl, methyl-4-methyl-, 3-fluoro-4-trichloromethylbenzoyl, 2-methyl-3-trifluoromethyl-4-trifluoromethylbenzoyl, 3-fluorobenzoyl, 4-fluorobenzoyl, 2-bromobenzoyl, 4-bromobenzoyl, 2-iodobenzoyl, 3-iodobenzoyl, 2, 3-dibromobenzoyl, 2, 4-diiodobenzoyl, 2, 5-difluorobenzoyl, 2, 6-dichlorobenzoyl, 2, 4, 6-trichlorobenzoyl, 2, 4-difluorobenzoyl, 3, 5-difluorobenzoyl, 2, 6-difluorobenzoyl, 2-chlorobenzoyl, 3-chlorobenzoyl, 4-chlorobenzoyl, 2, 3-dichlorobenzoyl, 4-chlorobenzoyl, 3-dichlorobenzoyl, 3-fluorobenzoyl, 4-fluorobenzoyl, 2, 4-iodobenzoyl, 2, 3-fluorobenzoyl, 2, 4-dichlorobenzoyl, 2, 5-dichlorobenzoyl, 3, 4-dichlorobenzoyl, 2, 6-dichlorobenzoyl, 3, 5-dichlorobenzoyl, 2, 4, 6-trifluorobenzoyl and 2, 4-difluorobenzoyl.

Examples of the halogen-substituted lower alkyl group include linear or branched alkyl groups having 1 to 6 carbon atoms having 1 to 3 halogen atoms as substituents, such as trifluoromethyl, trichloromethyl, chloromethyl, bromomethyl, fluoromethyl, iodomethyl, difluoromethyl, dibromomethyl, 2-chloroethyl, 2, 2, 2-trifluoroethyl, 2, 2, 2-trichloroethyl, 3-chloropropyl, 2, 3-dichloropropyl, 4, 4, 4-trichlorobutyl, 4-fluorobutyl, 5-chloropentyl, 3-chloro-2-methylpropyl, 5-bromohexyl and 5, 6-dibromohexyl.

Examples of the lower alkylenedioxy group include straight-chain or branched alkylenedioxy groups having 1 to 4 carbon atoms, such as methylenedioxy group, ethylenedioxy group, trimethylenedioxy group and tetramethylenedioxy group.

Examples of the amino group which may have a substituent selected from the group consisting of a lower alkyl group, a lower alkanoyl group, a benzoyl group and a cycloalkyl group include amino groups which may have 1 or 2 substituents selected from the group consisting of a linear or branched alkyl group having 1 to 6 carbon atoms, a linear or branched alkanoyl group having 1 to 6 carbon atoms, a benzoyl group and a cycloalkyl group having 3 to 16 carbon atoms, such as amino, methylamino, ethylamino, propylamino, isopropylamino, butylamino, tert-butylamino, pentylamino, hexylamino, dimethylamino, diethylamino, dipropylamino, dibutylamino, dipentylamino, dihexylamino, N-methyl-N-ethylamino, N-ethyl-N-propylamino, N-methyl-N-butylamino, N-methyl-N-hexylamino, N-methyl-N-acetylamino, N-acetylamino, N-formylamino, N-propionylamino, N-butyrylamino, N-isobutyrylamino, N-pentanoylamino, N-tert-butyrylamino, N-hexanoylamino, N-ethyl-N-acetylamino, N-benzoylamino, N-ethyl-N-benzoylamino, N-methyl-N-benzoylamino, N-acetyl-N-benzoylamino, cyclopropylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino, cycloheptylamino, cyclooctylamino, N-methyl-N-cyclohexylamino, N-methyl-N-cyclopentylamino, N-methyl-N-cycloheptylamino, N-cyclohexyl-N-acetylamino, N-butyrylamino, N-isobutyrylamino, N-pentanoylamino, N-tert-butyrylamino, N-hexanoylamino, N-ethyl-N-acetylamino, N-benzoylamino, N-methyl-N-benzoylamino, N-acetyl-benzoylamino, cyclopropylamino, cyclo, N-cyclopentyl-N-benzoylamino, cyclononyl amino, cyclodecylamino, cyclododecylamino, cyclotridecylamino, cyclotetradecylamino, cyclopentadecylamino, N-methyl-N-cyclohexadecyl amino, N-methyl-N-cyclononyl amino, N-methyl-N-cyclodecylamino, N-cycloundecyl-N-acetylamino, N-cyclohexadecyl-N-benzoylamino.

Examples of the lower alkanoyl group which may have a halogen atom as a substituent include, in addition to the above lower alkanoyl groups, straight-chain or branched alkanoyl groups having 2 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent, such as 2, 2, 2-trifluoroacetyl, 2, 2, 2-trichloroacetyl, 2-chloroacetyl, 2-bromoacetyl, 2-fluoroacetyl, 2-iodoacetyl, 2, 2-difluoroacetyl, 2, 2-dibromoacetyl, 3, 3, 3-trifluoropropionyl, 3, 3, 3-trichloropropionyl, 3-chloropropionyl, 2, 3-dichloropropionyl, 4, 4, 4-trichlorobutyryl, 4-fluorobutyryl, 5-chloropentanoyl, 3-chloro-2-methylpropionyl, 3-chloropropionyl, 2-trichloroacetyl, 2-chloroacetyl, 2-bromoacetyl, 2-iodoacetyl, 2, 6-bromohexanoyl and 5, 6-dibromohexanoyl.

Examples of the lower alkoxycarbonyl group include alkoxycarbonyl groups whose alkoxy moiety is a linear or branched alkoxy group having 1 to 6 carbon atoms, such as methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, tert-butoxycarbonyl, pentyloxycarbonyl and hexyloxycarbonyl.

Examples of the lower alkanoyloxy group include straight-chain or branched alkanoyloxy groups having 2 to 6 carbon atoms, such as acetoxy, propionyloxy, butyryloxy, isobutyryloxy, valeryloxy, tert-butyryloxy and hexanoyloxy.

Examples of the 5-or 6-membered saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms include pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, pyridyl, 1, 2, 5, 6-tetrahydropyridinyl, thienyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, 2H-pyrrolyl, imidazolidinyl, pyrazolyl, imidazolyl, pyrazolidinyl, furoyl, 2-imidazolinyl, 2-pyrrolinyl, furyl, oxazolyl, isoxazolidinyl, isoxazolyl, thiazolyl, isothiazolyl, pyranyl, 2-pyrazolidinyl, 1, 2, 4-triazolyl, 1, 2, 3-triazolyl, 1, 2, 5-triazolyl, thiazolidinyl, 2-thiazolinyl, 1, 2, 3, 4-tetrazolyl, 1, 3, 4-oxadiazolyl, tetrahydropyranyl and tetrahydrofuranyl.

From R¹¹And R¹²Examples of the 5 to 7-membered saturated heterocyclic ring which may be formed by connecting each other together with the nitrogen atom to which it is attached with or without a nitrogen atom, a sulfur atom or an oxygen atom include pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl and homopiperazinyl (homopiperazinyl).

Examples of the imidazolyl lower alkyl group include imidazolyl alkyl groups in which the alkyl moiety is a straight or branched alkyl group having 1 to 6 carbon atoms, such as (1, 2, 4 or 5-) imidazolyl methyl, 2- [ (1, 2, 4 or 5-) imidazolyl ] ethyl, 1- [ (1, 2, 4 or 5-) imidazolyl ] ethyl, 3- [ (1, 2, 4 or 5-) imidazolyl ] propyl, 4- [ (1, 2, 4 or 5-) imidazolyl ] butyl, 5- [ (1, 2, 4 or 5-) imidazolyl ] pentyl, 6- [ (1, 2, 4 or 5-) imidazolyl ] hexyl, 1-dimethyl-2- [ (1, 2, 4 or 5-) imidazolyl ] ethyl and 2-methyl-3- [ (1, 2, 4 or 5-) imidazolyl ] ethyl, 2. 4 or 5-) imidazolyl ] propyl.

Examples of the 1, 2, 4-triazolyl lower alkyl group include a 1, 2, 4-triazolyl alkyl group in which the alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as (1, 3, or 5-)1, 2, 4-triazolyl methyl group, 2- [ (1, 3, or 5-)1, 2, 4-triazolyl ] ethyl group, 1- [ (1, 3, or 5-)1, 2, 4-triazolyl ] ethyl group, 3- [ (1, 3, or 5-)1, 2, 4-triazolyl ] propyl group, 4- [ (1, 3, or 5-)1, 2, 4-triazolyl ] butyl group, 5- [ (1, 3, or 5-)1, 2, 4-triazolyl ] pentyl group, 6- [ (1, 3, or 5-)1, 2, 4-triazolyl ] hexyl group, 1, 1-dimethyl-2- [ (1, 3 or 5-)1, 2, 4-triazolyl ] ethyl and 2-methyl-3- [ (1, 3 or 5-)1, 2, 4-triazolyl ] propyl.

Examples of the 1, 2, 3-triazolyl lower alkyl group include a 1, 2, 3-triazolyl alkyl group in which the alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as (1, 4 or 5-)1, 2, 3-triazolyl methyl group, 2- [ (1, 4 or 5-)1, 2, 3-triazolyl ] ethyl group, 1- [ (1, 4 or 5-)1, 2, 3-triazolyl ] ethyl group, 3- [ (1, 4 or 5-)1, 2, 3-triazolyl ] propyl group, 4- [ (1, 4 or 5-)1, 2, 3-triazolyl ] butyl group, 5- [ (1, 4 or 5-)1, 2, 3-triazolyl ] pentyl group, 6- [ (1, 4 or 5-)1, 2, 3-triazolyl ] hexyl group, and, 1, 1-dimethyl-2- [ (1, 4 or 5-)1, 2, 3-triazolyl ] ethyl and 2-methyl-3- [ (1, 4 or 5-)1, 2, 3-triazolyl ] propyl.

Examples of the 1, 2, 5-triazolyl lower alkyl group include a 1, 2, 5-triazolyl alkyl group in which the alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as (1, 3 or 4-)1, 2, 5-triazolyl methyl group, 2- [ (1, 3 or 4-)1, 2, 5-triazolyl ] ethyl group, 1- [ (1, 3 or 4-)1, 2, 5-triazolyl ] ethyl group, 3- [ (1, 3 or 4-)1, 2, 5-triazolyl ] propyl group, 4- [ (1, 3 or 4-)1, 2, 5-triazolyl ] butyl group, 5- [ (1, 3 or 4-)1, 2, 5-triazolyl ] pentyl group, 6- [ (1, 3 or 4-)1, 2, 5-triazolyl ] hexyl group, and, 1, 1-dimethyl-2- [ (1, 3 or 4-)1, 2, 5-triazolyl ] ethyl and 2-methyl-3- [ (1, 3 or 4-)1, 2, 5-triazolyl ] propyl.

Examples of pyrazolyl lower alkyl include pyrazolyl alkyl whose alkyl moiety is a straight or branched chain alkyl having 1 to 6 carbon atoms, such as (1, 3, 4 or 5-) pyrazolyl methyl, 2- [ (1, 3, 4 or 5-) pyrazolyl ] ethyl, 1- [ (1, 3, 4 or 5-) pyrazolyl ] ethyl, 3- [ (1, 3, 4 or 5-) pyrazolyl ] propyl, 4- [ (1, 3, 4 or 5-) pyrazolyl ] butyl, 5- [ (1, 3, 4 or 5-) pyrazolyl ] pentyl, 6- [ (1, 3, 4 or 5-) pyrazolyl ] hexyl, 1-dimethyl-2- [ (1, 3, 4 or 5-) pyrazolyl ] ethyl and 2-methyl-3- [ (1, 3, 4 or 5-) pyrazolyl ] ethyl, 3. 4 or 5-) pyrazolyl ] propyl.

Examples of the pyrimidyl lower alkyl group which may have an oxy group as a substituent on the pyrimidine ring include pyrimidyl alkyl groups which may have 1 to 3 oxy groups as substituents on the pyrimidine ring and whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as (2, 4, 5 or 6-) pyrimidylmethyl, 2- [ (2, 4, 5 or 6-) pyrimidyl ] ethyl, 1- [ (2, 4, 5 or 6-) pyrimidyl ] ethyl, 3- [ (2, 4, 5 or 6-) pyrimidyl ] propyl, 4- [ (2, 4, 5 or 6-) pyrimidyl ] butyl, 5- [ (2, 4, 5 or 6-) pyrimidyl ] pentyl, 6- [ (2, 4, 5 or 6-) pyrimidyl ] hexyl, 1-dimethyl-2- [ (2, 6-), 4. 5 or 6-) pyrimidinyl ] ethyl, 2-methyl-3- [ (2, 4, 5 or 6-) pyrimidinyl ] propyl, [ (1, 3, 4 or 5-)2, 6-dioxopyrimidinyl ] methyl, [ (1, 3, 4, 5 or 6-) 2-oxopyrimidinyl ] methyl, [ (1, 2, 4 or 5-) 6-oxopyrimidinyl ] methyl, [ (1, 2, 5 or 6-) 4-oxopyrimidinyl ] methyl, [ (1, 3, 5 or 6-)2, 4-dioxopyrimidinyl ] methyl, 2- [ (4 or 6-)2, 5-dioxopyrimidinyl ] ethyl, 1- [ (1, 3, 4 or 5-)2, 6-dioxopyrimidinyl ] ethyl, 3- [ (1, 6) or 5-)2, 6-dioxopyrimidinyl ] ethyl, 3 or 5-)2, 4, 6-trioxopyrimidinyl ] propyl, 4- [ (1, 3, 4 or 5-)2, 6-dioxopyrimidinyl ] butyl, 5- [ (4 or 6-)2, 5-dioxopyrimidinyl ] pentyl, 6- [ (1, 3, 5 or 6-)2, 4-dioxopyrimidinyl ] hexyl, 1-dimethyl- [ (1, 3, 4 or 5-)2, 6-dioxopyrimidinyl ] ethyl and 2-methyl-3- [ (1, 3, 4 or 5-)2, 6-dioxopyrimidinyl ] propyl.

Examples of the 3, 5-dioxoisoxazolidin-4-ylidene lower alkyl group include a 3, 5-dioxoisoxazolidin-4-ylidene alkyl group whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as 3, 5-dioxoisoxazolidin-4-ylidenemethyl, 3, 5-dioxoisoxazolidin-4-ylideneethyl, 3, 5-dioxoisoxazolidin-4-ylidenepropyl, 3, 5-dioxoisoxazolidin-4-ylideneisopropyl, 3, 5-dioxoisoxazolidin-4-ylidenebutyl, 3, 5-dioxoisoxazolidin-4-ylidenepentyl and 3, 5-dioxoisoxazolidin-4-ylidenehexyl.

Examples of the 1, 2, 4-oxadiazolyl lower alkyl group which may have a lower alkyl group as a substituent on the 1, 2, 4-oxadiazolyl ring include 1, 2, 4-oxadiazolyl alkyl groups which may have a linear or branched alkyl group having 1 to 6 carbon atoms as a substituent on the 1, 2, 4-oxadiazolyl ring and whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as (3 or 5-)1, 2, 4-oxadiazolyl methyl group, 2- [ (3 or 5-)1, 2, 4-oxadiazolyl ] ethyl group, 1- [ (3 or 5-)1, 2, 4-oxadiazolyl ] ethyl group, 3- [ (3 or 5-)1, 2, 4-oxadiazolyl ] propyl group, 4- [ (3 or 5-)1, 2, 4-oxadiazolyl ] butyl, 5- [ (3 or 5-)1, 2, 4-oxadiazolyl ] pentyl, 6- [ (3 or 5-)1, 2, 4-oxadiazolyl ] hexyl, 1-dimethyl-2- [ (3 or 5-)1, 2, 4-oxadiazolyl ] ethyl, 2-methyl-3- [ (3 or 5-)1, 2, 4-oxadiazolyl ] propyl, 5-methyl-3- (1, 2, 4-oxadiazolyl) methyl, 3-ethyl-2- [5- (1, 2, 4-oxadiazolyl) ] ethyl, 1- [ 3-propyl-5- (1, 2, 4-oxadiazolyl) ] ethyl, 3- [ 5-butyl-3- (1, 2, 4-oxadiazolyl) ] propyl, 4- [ 3-pentyl-5- (1, 2, 4-oxadiazolyl) ] butyl, 5- [ 5-hexyl-3- (1, 2, 4-oxadiazolyl) ] pentyl, 6- [ 3-methyl-5- (1, 2, 4-oxadiazolyl) ] hexyl, 1-dimethyl-2- [ 5-isopropyl-3- (1, 2, 4-oxadiazolyl) ] ethyl and 2-methyl-3- [ 3-isobutyl-5- (1, 2, 4-oxadiazolyl) ] propyl.

Examples of the thiazolidinyl lower alkyl group which may have an oxy group as a substituent on the thiazolidine ring include thiazolidinyl alkyl groups which may have 1 to 3 oxy groups as substituents on the thiazolidine ring and whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as (2, 3, 4 or 5-) thiazolidinyl methyl, 2- [ (2, 3, 4 or 5-) thiazolidinyl ] ethyl, 1- [ (2, 3, 4 or 5-) thiazolidinyl ] ethyl, 3- [ (2, 3, 4 or 5-) thiazolidinyl ] propyl, 4- [ (2, 3, 4 or 5-) thiazolidinyl ] butyl, 5- [ (2, 3, 4 or 5-) thiazolidinyl ] pentyl, 6- [ (2, 3, 4 or 5-) thiazolidinyl ] hexyl, 1-dimethyl-2- [ (2, 3. 4 or 5-) thiazolidinyl ] ethyl, 2-methyl-3- [ (2, 3, 4 or 5-) thiazolidinyl ] propyl, 2, 4-dioxo-5-thiazolidinylmethyl, 2- [ 2-oxo- (3, 4 or 5-) thiazolidinyl ] ethyl, 1- [ 4-oxo- (2, 3 or 5-) thiazolidinyl ] ethyl, 3- [ 5-oxo- (2, 3 or 4-) thiazolidinyl ] propyl, 4- [2, 5-dioxo- (3 or 4-) thiazolidinyl ] butyl, 5- [2, 4, 5-trioxo-3-thiazolidinyl ] pentyl, 6- [4, 5-dioxo- (2 or 3-) thiazolidinyl ] hexyl, thiazolyl and the like, 1, 1-dimethyl-2- [2, 4-dioxo- (3 or 5-) thiazolidinyl ] ethyl, 2-methyl-3- [2, 4-dioxo- (3 or 5-) thiazolidinyl ] propyl and 3- [2, 4-dioxo- (3 or 5-) thiazolidinyl ] propyl.

Examples of the phenyl lower alkyl group which may have a lower alkylenedioxy group as a substituent on the benzene ring include, in addition to the above-mentioned phenyl lower alkyl groups, phenylalkyl groups which may have a straight chain or branched alkylenedioxy group having 1 to 4 carbon atoms as a substituent on the benzene ring and whose alkyl moiety is a straight chain or branched alkyl group having 1 to 6 carbon atoms, such as 3, 4-methylenedioxybenzyl group, 3, 4-trimethylenedioxyphenylmethyl group, 2- (2, 3-ethylenedioxyphenyl) ethyl group, 1- (3, 4-trimethylenedioxyphenyl) ethyl group, 3- (2, 3-tetramethylenedioxyphenyl) propyl group, 4- (3, 4-methylenedioxyphenyl) butyl group, 5- (2, 3-ethylenedioxyphenyl) pentyl group, 6- (3, 4-trimethylenedioxyphenyl) hexyl, 1-dimethyl-2- (2, 3-methylenedioxyphenyl) ethyl and 2-methyl-3- (3, 4-ethylenedioxyphenyl) propyl.

Examples of the lower alkoxycarbonyl lower alkyl group include alkoxycarbonylalkyl groups whose alkoxy moiety is a linear or branched alkoxy group having 1 to 6 carbon atoms and whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as methoxycarbonylmethyl, ethoxycarbonylmethyl, 2-methoxycarbonylethyl, 2-ethoxycarbonylethyl, 1-ethoxycarbonylethyl, 3-methoxycarbonylpropyl, 3-ethoxycarbonylpropyl, 4-ethoxycarbonylbutyl, 5-isopropoxycarbonylpentyl, 6-propoxycarbonylhexyl, 1-dimethyl-2-butoxycarbonylethyl, 2-methyl-3-tert-butoxycarbonylpropyl, 2-pentyloxycarbonylethyl and hexyloxycarbonylmethyl.

Examples of the carboxy lower alkyl group include carboxyalkyl groups whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as carboxymethyl, 2-carboxyethyl, 1-carboxyethyl, 3-carboxypropyl, 4-carboxybutyl, 5-carboxypentyl, 6-carboxyhexyl, 1-dimethyl-2-carboxyethyl and 2-methyl-3-carboxypropyl.

Examples of the lower alkanoyl group substituted with a morpholino group include a morpholino-substituted alkanoyl group whose alkanoyl moiety is a straight-chain or branched alkanoyl group having 2 to 6 carbon atoms, for example 2- [ (2, 3 or 4-) morpholinyl ] acetyl, 3- [ (2, 3 or 4-) morpholinyl ] propanoyl, 2- [ (2, 3 or 4-) morpholinyl ] propanoyl, 4- [ (2, 3 or 4-) morpholinyl ] butanoyl, 5- [ (2, 3 or 4-) morpholinyl ] pentanoyl, 6- [ (2, 3 or 4-) morpholinyl ] hexanoyl, 2-dimethyl-2- [ (2, 3 or 4-) morpholinyl ] propanoyl and 2-methyl-3- [ (2, 3 or 4-) morpholinyl ] propanoyl.

Examples of the piperazinocarbonyl lower alkyl group which may be substituted on the piperazine ring by a phenyl lower alkyl group which may have a lower alkylenedioxy group as a substituent on the benzene ring include piperazinocarbonylalkyl groups which may be substituted on the piperazine ring by 1 to 3 phenylalkyl groups which may be substituted on the piperazine ring by a straight-chain or branched-chain alkylenedioxy group which may have 1 to 6 carbon atoms and whose alkyl moiety may be substituted by a straight-chain or branched-chain alkyl group having 1 to 6 carbon atoms, such as [ (1, 2 or 3-) piperazinyl ] carbonylmethyl group, 2- [ (1, 2 or 3-) piperazinyl ] carbonylethyl group, 1- [ (1, 2 or 3-) piperazinyl ] carbonylethyl group, 3- [ (1, 2 or 3-) piperazinyl ] carbonylpropyl group, 4- [ (1, 2 or 3- ] -carbonylpropyl group, 2 or 3-) piperazinyl ] carbonylbutyl, 5- [ (1, 2, or 3-) piperazinyl ] carbonylpentyl, 6- [ (1, 2, or 3-) piperazinyl ] carbonylhexyl, 1-dimethyl-2- [ (1, 2, or 3-) piperazinyl ] carbonylethyl, 2-methyl-3- [ (1, 2, or 3-) piperazinyl ] carbonylpropyl, (4-benzyl-1-piperazinylcarbonyl) methyl, 2- [4- (2-phenylethyl) -1-piperazinylcarbonyl ] ethyl, 1- [4- (3-phenylpropyl) -1-piperazinylcarbonyl ] ethyl, 3- [4- (4-phenylbutyl) -1-piperazinylcarbonyl ] propyl, methyl-ethyl, ethyl-propyl-ethyl, propyl-ethyl, propyl-ethyl, 4- [4- (5-phenylpentyl) -1-piperazinylcarbonyl ] butyl, 5- [4- (6-phenylpropyl) -1-piperazinylcarbonyl ] pentyl, 6- (4-benzyl-1-piperazinylcarbonyl) hexyl, 1-dimethyl-2- (4-benzyl-1-piperazinylcarbonyl) ethyl, 2-methyl-3- (4-benzyl-1-piperazinylcarbonyl) propyl, [4- (3, 4-methylenedioxybenzyl) -1-piperazinylcarbonyl ] methyl, 2- {4- [2- (2, 3-ethylenedioxyphenyl) ethyl ] -1-piperazinylcarbonyl } ethyl, methyl, ethyl, propyl, butyl, pentyl, hexyl, methyl, pentyl, hexyl, 1- {4- [3- (3, 4-trimethylenedioxyphenyl) propyl ] -1-piperazinylcarbonyl } ethyl, 3- {4- [4- (2, 3-tetramethylenedioxyphenyl) butyl ] -1-piperazinylcarbonyl } propyl, 4- {4- [5- (3, 4-methylenedioxyphenyl) pentyl ] -1-piperazinylcarbonyl } butyl, 5- {4- [3- (2, 3-ethylenedioxyphenyl) propyl ] -1-piperazinylcarbonyl } pentyl, 6- [4- (3, 4-trimethylenedioxyphenyl) -1-piperazinylcarbonyl ] hexyl, 1-dimethyl-2- [4- (2, 3-tetramethylenedioxybenzyl) -1-piperazinylcarbonyl ] ethyl, 2-methyl-3- [4- (3, 4-methylenedioxybenzyl) -1-piperazinylcarbonyl ] propyl, (3, 4-diphenylmethyl-1-piperazinylcarbonyl) methyl, (3, 4, 5-trityl-1-piperazinylcarbonyl) methyl, [2, 4-bis (3, 4-methylenedioxybenzyl) -1-piperazinylcarbonyl ]) methyl, [2, 4, 6-tris (3, 4-methylenedioxybenzyl) -1-piperazinylcarbonyl ] methyl and [ 3-benzyl-4- (3, 4-methylenedioxybenzyl) -1-piperazinylcarbonyl ] methyl.

Examples of the piperazinyl lower alkanoyl group which may be substituted on the piperazine ring with a phenyl lower alkyl group which may have a lower alkylenedioxy group as a substituent on the benzene ring include piperazinyl alkanoyl groups which may have an alkanoyl moiety of a straight chain or branched chain having 2 to 6 carbon atoms and which may be substituted on the piperazine ring with a straight chain or branched chain alkylenedioxy group which may have 1 to 4 carbon atoms on the benzene ring as a substituent and an alkyl moiety of a straight chain or branched chain having 1 to 6 carbon atoms, such as 2- [ (1, 2 or 3-) piperazinyl ] acetyl, 3- [ (1, 2 or 3-) piperazinyl ] propionyl, 2- [ (1, 2 or 3-) piperazinyl ] propionyl, 4- [ (1, 2 or 3-) piperazinyl ] butyryl, 5- [ (1, 2 or 3-) piperazinyl ] butyryl, 2 or 3-) piperazinyl ] pentanoyl, 6- [ (1, 2 or 3-) piperazinyl ] hexanoyl, 2-dimethyl-3- [ (1, 2 or 3-) piperazinyl ] propionyl, 2-methyl-3- [ (1, 2 or 3-) piperazinyl ] propionyl, 2- (4-benzyl-1-piperazinyl) acetyl, 3- [4- (2-phenylethyl) -1-piperazinyl ] propionyl, 2- [4- (3-phenylpropyl) -1-piperazinyl ] propionyl, 4- [4- (4-phenylbutyl) -1-piperazinyl ] butyryl, 5- [4- (5-phenylpentyl) -1-piperazinyl ] pentanoyl, hexanoyl, and their salts, 6- [4- (6-phenylpropyl) -1-piperazinyl ] hexanoyl, 6- (4-benzyl-1-piperazinyl) hexanoyl, 2-dimethyl-3- (4-benzyl-1-piperazinyl) propionyl, 2-methyl-3- (4-benzyl-1-piperazinyl) propionyl, 2- [4- (3, 4-methylenedioxybenzyl) -1-piperazinyl) acetyl, 3- {4- [2- (2, 3-ethylenedioxyphenyl) ethyl ] -1-piperazinyl } propionyl, 2- {4- [3- (3, 4-trimethylenedioxyphenyl) propyl ] -1-piperazinyl } propionyl, methyl-ethyl-2-methyl-3- (4-methylenedioxyphenyl) propyl ] -1-piperazinyl } propionyl, methyl-ethyl-2-methyl-4-piperazinyl, methyl-1-methyl-ethyl-1-piperazinyl, 4- {4- [4- (2, 3-tetramethylenedioxyphenyl) butyl ] -1-piperazinyl } butanoyl, 5- {4- [5- (3, 4-methylenedioxyphenyl) pentyl ] -1-piperazinyl } pentanoyl, 5- {4- [3- (2, 3-ethylenedioxyphenyl) propyl ] -1-piperazinyl } pentanoyl, 6- [4- (3, 4-trimethylenedioxybenzyl) -1-piperazinyl ]) hexanoyl, 2-dimethyl-3- [4- (2, 3-tetramethylenedioxybenzyl) -1-piperazinyl ] propanoyl, 2-methyl-3- [4- (3, 4-methylenedioxybenzyl) -1-piperazinyl ] propionyl, 2- (3, 4-benzhydryl-1-piperazinyl) acetyl, 2- (3, 4, 5-trityl-1-piperazinyl) acetyl, 2- [2, 4-bis (3, 4-methylenedioxybenzyl) -1-piperazinyl ]) acetyl, 2- [2, 4, 6-tris (3, 4-methylenedioxybenzyl) -1-piperazinyl ]) acetyl and 2- [ 3-benzyl-4- (3, 4-methylenedioxybenzyl) -1-piperazinyl ]) acetyl.

Examples of the lower alkyl substituted by morpholinylcarbonyl include morpholinylcarbonylalkyl whose alkyl moiety is a straight-chain or branched-chain alkyl having 1 to 6 carbon atoms, such as [ (2, 3, or 4-) morpholinyl ] carbonylmethyl, 2- [ (2, 3, or 4-) morpholinyl ] carbonylethyl, 1- [ (2, 3, or 4-) morpholinyl ] carbonylethyl, 3- [ (2, 3, or 4-) morpholinyl ] carbonylpropyl, 4- [ (2, 3, or 4-) morpholinyl ] carbonylbutyl, 5- [ (2, 3, or 4-) morpholinyl ] carbonylpentyl, 6- [ (2, 3, or 4-) morpholinyl ] carbonylhexyl, 1-dimethyl-2- [ (2, 3, or 4-) morpholinyl ] carbonylethyl and 2-methyl-3- [ (2, 3, or 4-) morpholinyl ] carbonylethyl, 3 or 4-) morpholinyl ] carbonylpropyl.

Examples of the imidazolyl lower alkanoyl group include imidazolyl alkanoyl groups whose alkanoyl moiety is a straight or branched alkanoyl group having 2 to 6 carbon atoms, for example 2- [ (1, 2, 4 or 5-) imidazolyl ] acetyl, 3- [ (1, 2, 4 or 5-) imidazolyl ] propionyl, 2- [ (1, 2, 4 or 5-) imidazolyl ] propionyl, 4- [ (1, 2, 4 or 5-) imidazolyl ] butyryl, 5- [ (1, 2, 4 or 5-) imidazolyl ] pentanoyl, 6- [ (1, 2, 4 or 5-) imidazolyl ] hexanoyl, 2-dimethyl-3- [ (1, 2, 4 or 5-) imidazolyl ] propionyl and 2-methyl-3- [ (1, 2, 4 or 5-) imidazolyl ] propionyl.

Examples of the cycloalkylcarbonyl group include cycloalkylcarbonyl groups whose cycloalkyl moiety is a cycloalkyl group having 3 to 16 carbon atoms, such as cyclopropylcarbonyl group, cyclobutylcarbonyl group, cyclopentylcarbonyl group, cyclohexylcarbonyl group, cycloheptylcarbonyl group, cyclooctylcarbonyl group, cyclononylcarbonyl group, cyclodecylcarbonyl group, cycloundecylcarbonyl group, cyclododecylcarbonyl group, cyclotridecylcarbonyl group, cyclotetradecylcarbonyl group, cyclopentadecylcarbonyl group, and cyclohexadecylcarbonyl group.

Examples of the lower alkanoyl group which may have a lower alkyl group as a substituent include straight-chain or branched alkanoyl groups having 2 to 6 carbon atoms substituted with an amino group which may have 1 or 2 straight-chain or branched-chain alkyl groups containing 1 to 6 carbon atoms as a substituent, such as aminoacetyl group, 2-aminopropionyl group, 3-aminopropionyl group, 4-aminobutyryl group, 5-aminopentanoyl group, 6-aminocaproyl group, 2-dimethyl-3-aminopropionyl group, 2-methyl-3-aminopropionyl group, methylaminoacetyl group, 2-ethylaminopropionyl group, 3-propylaminopropionyl group, 3-isopropylaminopropionyl group, 4-butylaminobutyryl group, 5-pentylaminopentanoyl group, 6-hexylaminocaproyl group, dimethylaminoacetyl group, substituted with a lower alkyl group, 3-diisopropylaminopropionyl, (N-ethyl-N-propylamino) acetyl and 2- (N-methyl-N-hexylamino) acetyl.

Examples of the lower alkylene group which may have a hydroxyl group as a substituent include, in addition to the above-mentioned lower alkylene groups, straight-chain or branched alkylene groups having 1 to 6 carbon atoms which may have 1 to 3 hydroxyl groups as substituents, such as 1-hydroxymethylene, 2-hydroxyethylene, 1-hydroxyethylene, 2-hydroxytrimethylene, 3-hydroxytrimethylene, 1-hydroxytrimethylene, 3-hydroxy-2-methyltrimethylene, 1-hydroxy-2-methyltrimethylene, 3-hydroxy-2, 2-dimethyltrimethylene, 1-hydroxy-2, 2-dimethyltrimethylene, 3-hydroxy-1-methyltrimethylene, 2-hydroxy-1-methyltrimethylene, 1-hydroxymethylmethylene, 2-hydroxymethyltrimethylene, 2-hydroxymethyl-2-methyltrimethylene, (2-hydroxyethyl) methylene, (1-hydroxyethyl) methylene, 4-hydroxytetramethylene, 2-hydroxytetramethylene, 3-hydroxytetramethylene, 1-hydroxytetramethylene, 5-hydroxypentamethylene, 4-hydroxypentamethylene, 3-hydroxypentamethylene, 2-hydroxypentamethylene, 1-hydroxypentamethylene, 6-hydroxyhexamethylene, 5-hydroxyhexamethylene, 4-hydroxyhexamethylene, 3-hydroxyhexamethylene, 2-hydroxyhexamethylene, 1, 2-dihydroxytrimethylene, 2, 2, 4-trihydroxy tetramethylene, 1, 2, 6-trihydroxy hexamethyleneene and 3, 4, 5-trihydroxy pentamethylene.

Examples of the alkyl group which may have a hydroxyl group as a substituent include, in addition to the above-mentioned lower alkyl group, a straight-chain or branched alkyl group having 1 to 16 carbon atoms which may have 1 to 3 hydroxyl groups as substituents, such as heptyl group, octyl group, nonyl group, decyl group, undecyl group, dodecyl group, tridecyl group, tetradecyl group, pentadecyl group, 1-methylhexyl group, hexadecyl group, hydroxymethyl group, 2-hydroxyethyl group, 1-hydroxyethyl group, 3-hydroxypropyl group, 2, 3-dihydroxypropyl group, 4-hydroxybutyl group, 1-dimethyl-2-hydroxyethyl group, 5, 4-trihydroxypentyl group, 5-hydroxypentyl group, 6-hydroxyhexyl group, 1-hydroxyisopropyl group and 2-methyl-3-hydroxypropyl group.

Examples of the hydroxyl-substituted alkyl group include linear or branched alkyl groups having 1 to 16 carbon atoms having 1 to 3 hydroxyl groups as substituents, such as hydroxymethyl, 2-hydroxyethyl, 1-hydroxyethyl, 3-hydroxypropyl, 2, 3-dihydroxypropyl, 4-hydroxybutyl, 1-dimethyl-2-hydroxyethyl, 5, 4-trihydroxypentyl, 5-hydroxypentyl, 6-hydroxyhexyl, 1-hydroxyisopropyl and 2-methyl-3-hydroxypropyl.

Examples of the cycloalkyl group which may have a substituent selected from the group consisting of a hydroxyl group and a lower alkyl group include, in addition to the above-mentioned cycloalkyl groups, cycloalkyl groups having 3 to 16 carbon atoms which may have 1 to 3 substituents selected from the group consisting of a hydroxyl group and a linear or branched alkyl group having 1 to 6 carbon atoms, such as 2-hydroxycyclopropyl, 3-hydroxycyclobutyl, 3-hydroxycyclopentyl, 2-hydroxycyclohexyl, 4-hydroxycyclohexyl, 3-hydroxycyclocycloheptyl, 4-hydroxycyclooctyl, 5-hydroxycyclononyl, 3-hydroxycyclodecyl, 4-hydroxycycloundecyl, 5-hydroxycyclododecyl, 6-hydroxycyclotridecyl, 7-hydroxycyclotetradecyl, 6-hydroxycyclopentadecyl, 8-hydroxycyclohexadecyl, 2, 4-dihydroxycyclohexyl, 2-hydroxycyclodecyl, 3-hydroxycyclododecyl, and 3-hydroxycyclo, 2, 4, 6-trihydroxycyclohexyl, 1-methylcyclopentyl, 2-ethylcyclopropyl, 3-n-propylcyclobutyl, 2-n-butylcyclohexyl, 4-n-pentylcycloheptyl, 4-n-hexylcyclooctyl, 2, 3-dimethylcyclohexyl, 2, 3, 4-trimethylcyclohexyl and 2-methyl-4-hydroxycyclohexyl.

Examples of the phenoxy lower alkyl group include phenoxyalkyl groups whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as phenoxymethyl, 2-phenoxyethyl, 1-phenoxyethyl, 3-phenoxypropyl, 4-phenoxybutyl, 1-dimethyl-2-phenoxyethyl, 5-phenoxypentyl, 6-phenoxyhexyl, 1-phenoxyisopropyl and 2-methyl-3-phenoxypropyl.

Examples of the amino lower alkoxy group which may have a lower alkyl group as a substituent include a linear or branched alkoxy group having 1 to 6 carbon atoms which is substituted with an amino group which may have 1 or 2 linear or branched alkyl groups having 1 to 6 carbon atoms, such as aminomethoxy, 2-aminoethoxy, 1-aminoethoxy, 3-aminopropoxy, 4-aminobutoxy, 5-aminopentoxy, 6-aminohexyloxy, 1-dimethyl-2-aminoethoxy, 2-methyl-3-aminopropoxy, methylaminomethoxy, 1-ethylaminoethoxy, 2-propylaminoethoxy, 3-isopropylaminopropoxy, 4-butylaminobutoxy, 5-pentylaminopentoxy, 6-hexylaminohexyloxy, a, Dimethylaminomethoxy, 2-diethylaminoethoxy, 2-diisopropylaminoethoxy, (N-ethyl-N-propylamino) methoxy and 2- (N-methyl-N-hexylamino) ethoxy.

Examples of the hydroxy-substituted lower alkyl group include straight-chain or branched alkyl groups having 1 to 6 carbon atoms having 1 to 3 hydroxy groups as substituents, such as hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 3-hydroxypropyl, 2, 3-dihydroxypropyl, 4-hydroxybutyl, 1-dimethyl-2-hydroxyethyl, 5, 4-trihydroxypentyl, 5-hydroxypentyl, 6-hydroxyhexyl, 1-hydroxyisopropyl and 2-methyl-3-hydroxypropyl.

Examples of the amino group which may have a lower alkylsulfonyl group as a substituent include an amino group which may have 1 or 2 linear or branched alkylsulfonyl groups containing 1 to 6 carbon atoms as a substituent, for example, amino, methylsulfonylamino, ethylsulfonylamino, propylsulfonylamino, isopropylsulfonylamino, butylsulfonylamino, tert-butylsulfonylamino, pentylsulfonylamino, hexylsulfonylamino, dimethylsulfonylamino, diethylsulfonylamino, dipropylsulfonylamino, dibutylsulfonylamino, dipentylsulfonylamino, dihexylsulfonylamino, N-methylsulfonyl-N-ethylsulfonylamino, N-ethylsulfonyl-N-propylsulfonylamino, N-methylsulfonyl-N-butylsulfonylamino and N-methylsulfonyl-N-hexylsulfonylamino.

Examples of the lower alkynyl group include straight-chain or branched alkynyl groups having 2 to 6 carbon atoms, such as ethynyl, 2-propynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 2-pentynyl and 2-hexynyl.

Examples of the anilino group which may have a halogen atom as a substituent on the benzene ring include anilino groups which may have 1 to 3 halogen atoms as substituents on the benzene ring, such as anilino group, 2-fluoroanilino group, 3-fluoroanilino group, 4-fluoroanilino group, 2-bromoanilino group, 3-bromoanilino group, 4-bromoanilino group, 2-iodoanilino group, 3-iodoanilino group, 4-iodoanilino group, 2, 3-dibromoanilino group, 2, 4-diiodoanilino group, 2, 5-difluoroanilino group, 2, 6-dichloroanilino group, 2, 4, 6-trichloroanilino group, 2, 6-difluoroanilino group, 3, 5-difluoroanilino group, 2, 6-difluoroanilino group, 2-chloroanilino group, 3-chloroanilino group, 4-chloroanilino group, 2-chloroanilino group, 2, 3-dichloroanilino, 2, 4-dichloroanilino, 2, 5-dichloroanilino, 3, 4-dichloroanilino, 2, 6-dichloroanilino, 3, 5-dichloroanilino, 2, 4, 6-trifluoroanilino, 2, 4-difluoroanilino and 3, 4-difluoroanilino.

Examples of the piperazinyl group which may have a lower alkyl group as a substituent on the piperazine ring include piperazinyl groups which may have 1 to 3 straight or branched alkyl groups containing 1 to 6 carbon atoms as substituents on the piperazine ring, such as (1-, 2-or 3-) piperazinyl, 4-methyl- (1-, 2-or 3-) piperazinyl, 2, 3-dimethyl- (1 or 5-) piperazinyl and 2, 3, 4-trimethyl- (1-, 5-or 6-) piperazinyl.

Examples of the pyrrolidinyl group which may have an oxy group as a substituent on the pyrrolidine ring include pyrrolidinyl groups which may have 1 or 2 oxy groups as substituents on the pyrrolidine ring, such as (1-, 2-or 3-) pyrrolidinyl group, 2-oxo- (1-, 3-, 4-or 5-) pyrrolidinyl group, 3-oxo- (1-, 2-, 4-or 5-) pyrrolidinyl group, 2, 3-dioxo- (1-, 4-or 5-) pyrrolidinyl group and 2, 5-dioxo- (1-, 3-or 4-) pyrrolidinyl group.

Examples of the lower alkanoylamino group include a straight or branched alkanoylamino group having 2 to 6 carbon atoms having 1 to 3 halogen atoms as a substituent, such as acetylamino, propionylamino, butyrylamino, pentanoylamino, 2-methylpropionylamino and hexanoylamino.

Examples of the phenyl group which may be substituted on the benzene ring with 1 to 3 groups selected from the group consisting of a lower alkyl group, a lower alkoxy group which may have a halogen atom as a substituent, a halogen atom, an amino lower alkoxy group which may have a lower alkyl group as a substituent, a lower alkyl group substituted with a hydroxyl group, a phenyl lower alkyl group, a lower alkynyl group, an amino group which may have a lower alkylsulfonyl group as a substituent, a lower alkylthio group, a cycloalkyl group, a phenylthio group, an adamantyl group, an anilino group which may have a halogen atom as a substituent on the benzene ring, a lower alkoxycarbonyl group, a piperazinyl group which may have a lower alkyl group as a substituent on the piperazine ring, a lower alkanoylamino group, a cyano group, a pyrrolidinyl group which may have an oxy group as a substituent on the pyrrolidine ring and a phenoxy group include a phenyl group which may be substituted on the benzene ring with 1 to 3 groups selected from the group consisting of a straight chain or branched alkyl group having 1 to 6 carbon atoms, a, A halogen atom, an aminoalkoxy group whose alkoxy group moiety is a straight-chain or branched-chain alkoxy group having 1 to 6 carbon atoms and which may have 1 or 2 straight-chain or branched-chain alkyl groups containing 1 to 6 carbon atoms as substituents, a straight-chain or branched-chain alkyl group having 1 to 3 hydroxyl groups as substituents and having 1 to 6 carbon atoms, a phenylalkyl group whose alkyl group moiety is a straight-chain or branched-chain alkyl group having 1 to 6 carbon atoms, a straight-chain or branched-chain alkynyl group having 2 to 6 carbon atoms, an amino group which may have 1 or 2 straight-chain or branched-chain alkylsulfonyl groups containing 1 to 6 carbon atoms as substituents, a straight-chain or branched-chain alkylthio group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 16 carbon atoms, a phenylthio group, an adamantyl group, an anilino group which may have 1 to 3 halogen atoms as substituents on the benzene ring, an alkoxycarbonyl group whose alkoxy group moiety is a straight-chain or branched-chain alkoxy group having 1 to 6 carbon atoms, An amino group which may have 1 or 2 straight-chain or branched alkanoyl groups having 2 to 6 carbon atoms, a cyano group, a piperazinyl group which may have 1 to 3 straight-chain or branched-chain alkyl groups having 1 to 6 carbon atoms as substituents on the piperazine ring, a phenyl group which may be substituted with 1 to 3 groups of a pyrrolidinyl group and a phenoxy group which may have 1 or 2 oxy groups as substituents on the pyrrolidine ring, such as a phenyl group, a 2-methylphenyl group, a 3-methylphenyl group, a 4-methylphenyl group, a 2-ethylphenyl group, a 3-ethylphenyl group, a 4-ethylphenyl group, a 2-isopropylphenyl group, a 4-isopropylphenyl group, a 3-butylphenyl group, a 4-pentylphenyl group, a 4-hexylphenyl group, a 3, 4-dimethylphenyl group, a 3, 4-diethylphenyl group, a 2, 4-dimethylphenyl group, a 2, 5-dimethylphenyl, 2, 6-dimethylphenyl, 3, 4, 5-trimethylphenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 2-ethoxyphenyl, 3-ethoxyphenyl, 4-isopropoxyphenyl, 3-butoxyphenyl, 4-pentyloxyphenyl, 4-hexyloxyphenyl, 3, 4-dimethoxyphenyl, 3, 4-diethoxyphenyl, 2, 4-dimethoxyphenyl, 2, 5-dimethoxyphenyl, 2, 6-dimethoxyphenyl, 3, 4, 5-trimethoxyphenyl, 2-trifluoromethoxyphenyl, 3-trifluoromethoxyphenyl, 4-trifluoromethoxyphenyl, 2- (bromomethoxy) phenyl, 2-dimethoxyphenyl, 3-dimethylmethoxyphenyl, 4-dimethoxyphenyl, 2- (bromomethoxy) phenyl, and the like, 3- (2-chloroethoxy) phenyl, 4- (2, 3-dichloropropoxy) phenyl, 4- (4-fluorobutoxy) phenyl, 3- (5-chloropentyloxy) phenyl, 4- (5-bromohexyloxy) phenyl, 4- (5, 6-dibromohexyloxy) phenyl, 3, 4-bis (trifluoromethoxy) phenyl, 3, 4-bis (4, 4, 4-trichlorobutoxy) phenyl, 2, 4-bis (3-chloro-2-methoxypropyl) phenyl, 2, 5-bis (3-chloropropyloxy) phenyl, 2, 6-bis (2, 2, 2-trifluoroethoxy) phenyl, 3, 4, 5-tris (trifluoromethoxy) phenyl, 4- (2, 2, 2-trichloroethoxy) phenyl, 3- (4-chloro-2-n-butoxy) phenyl, 4- (2, 2-trichloroethoxy) phenyl, 2-methyl-4-trifluoromethoxyphenyl group, 3-ethyl-4-trichloromethoxyphenyl group, 2-methoxy-4-trifluoromethoxyphenyl group, 3-ethoxy-4-trichloromethoxyphenyl group, 2-methyl-3-trifluoromethoxyphenyl-4-trifluoromethoxyphenyl group, 2-phenoxyphenyl group, 3-phenoxyphenyl group, 4-phenoxyphenyl group, 2, 3-diphenoxyphenyl group, 3, 4-diphenoxyphenyl group, 2, 6-diphenoxyphenyl group, 3, 4, 5-triphenoxyphenyl group, 2-methyl-4-phenoxyphenyl group, 3-ethyl-4-phenoxyphenyl group, 2-methoxy-4-phenoxyphenyl group, 2-ethoxy-4-phenoxyphenyl group, 3-ethoxy-4-phenoxyphenyl group, 2-methoxy-4-phenoxyphenyl group, 2-ethoxy-4-phenoxyphenyl group, 3-ethoxy-4-phenoxyphenyl, 2-methyl-3-phenoxy-4-trifluoromethoxyphenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 2, 3-dichlorophenyl, 2, 4-dichlorophenyl, 2, 5-dichlorophenyl, 3, 4-dichlorophenyl, 2, 6-dichlorophenyl, 3, 5-dichlorophenyl, 2, 4, 6-trichlorophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 2, 5-difluorophenyl, 2, 4-difluorophenyl, 3, 5-difluorophenyl, 2, 6-difluorophenyl, 2, 4, 6-trifluorophenyl, 2-bromophenyl, 3-bromophenyl, 2, 4-dichlorophenyl, 2-chlorophenyl, 4-dichlorophenyl, 2, 4-dichlorophenyl, 3, 4-difluorophenyl, 4-bromophenyl, 2-iodophenyl, 3-iodophenyl, 4-iodophenyl, 2, 3-dibromophenyl, 2, 4-diiodophenyl, 4-methylthiophenyl, 4-cyclohexylphenyl, 4-chloro-2-anilinophenyl, 2- (4-chloroanilino) -5-ethoxycarbonylphenyl, 4- [2- (N, N-diethylamino) ethoxy ] phenyl, 4- (4-methyl-1-piperazinyl) phenyl, 4- (2-oxo-1-pyrrolidinyl) phenyl, 4-methylsulfonylaminophenyl, 4- (2-hydroxyethyl) phenyl, 4-phenylmethylphenyl, 4-ethynylphenyl, 4-phenylthiophenyl, 4-iodophenyl, 2, 3-dibromophenyl, 2, 4-diiodophenyl, 4-methylthiophenyl, 4- (4-chloroanilino) phenyl, 4- (4, 4- (1-adamantyl) phenyl, 5-acetylamino-2-chlorophenyl, 2-propionylaminophenyl, 3-cyanophenyl, 2-cyanophenyl, 4-cyanophenyl, 3, 4-dicyanophenyl and 3, 4, 5-tricyanophenyl.

Examples of the phenyl lower alkyl group which may be substituted on the benzene ring with 1 to 3 groups selected from the group consisting of a halogen atom, a lower alkoxy group which may have a halogen atom as a substituent and a lower alkyl group include, in addition to the above-mentioned phenyl lower alkyl group, a phenylalkyl group whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms and which may be substituted on the benzene ring with 1 to 3 groups selected from the group consisting of a halogen atom, a straight-chain or branched alkoxy group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent and a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as 4-fluorobenzyl, 2-chlorobenzyl, 3-chlorobenzyl, 4-chlorobenzyl, 2- (2-fluorophenyl) ethyl, 2- (4-chlorophenyl) ethyl, 3, 4-dibromobenzyl, 3, 4-diiodobenzyl, 2, 4-difluorobenzyl, 2, 5-dichlorobenzyl, 2, 6-dichlorobenzyl, 3, 4, 5-trifluorobenzyl, 3- (4-chlorophenyl) propyl, 1- (2-bromophenyl) ethyl, 4- (3-fluorophenyl) butyl, 5- (4-iodophenyl) pentyl, 6- (4-chlorophenyl) hexyl, 1-dimethyl-2- (3-fluorophenyl) ethyl, 2-methyl-3- (4-chlorophenyl) propyl, 2-methylbenzyl, 2- (3-methylphenyl) ethyl, 3- (4-methylphenyl) propyl, 1- (2-ethylphenyl) ethyl, 2-methylbenzyl, 3- (4-methylphenyl) propyl, 3- (2-ethylphenyl) ethyl, 2-methylbenzyl, 3- (4-fluorophenyl) propyl, 3- (2-ethylphenyl) ethyl, 2-trifluoromethylphenyl), 4- (3-ethylphenyl) butyl, 5- (4-ethylphenyl) pentyl, 6- (4-isopropylphenyl) hexyl, 1-dimethyl-2- (3-butylphenyl) ethyl, 2-methyl-3- (4-pentylphenyl) propyl, 4-hexylbenzyl, 3, 4-dimethylbenzyl, 3, 4-diethylbenzyl, 2, 4-dimethylbenzyl, 2, 5-dimethylbenzyl, 2, 6-dimethylbenzyl, 3, 4, 5-trimethylbenzyl, 2-methoxybenzyl, 2- (2-methoxyphenyl) ethyl, 2- (3-methoxyphenyl) ethyl, 2- (4-methoxyphenyl) ethyl, 4-methoxybenzyl group, 1- (2-ethoxyphenyl) ethyl group, 3- (3-ethoxyphenyl) propyl group, 4- (4-ethoxyphenyl) butyl group, 5- (4-isopropoxyphenyl) pentyl group, 6- (3-butoxyphenyl) hexyl group, 1-dimethyl-2- (4-pentyloxyphenyl) ethyl group, 2-methyl-3- (4-hexyloxyphenyl) propyl group, 3, 4-dimethoxybenzyl group, 3, 4-diethoxybenzyl group, 2, 4-dimethoxybenzyl group, 2, 5-dimethoxybenzyl group, 2, 6-dimethoxybenzyl group, 3, 4, 5-trimethoxybenzyl group, 2-trifluoromethoxybenzyl group, 2-ethoxybenzyl group, 3- (4-ethoxyphenyl) butyl group, 4- (4-hexyloxyphenyl) hexyl group, 2, 1-dimethyl-2- (4-pentyloxyphenyl) ethyl group, 2-, 3-trifluoromethoxybenzyl group, 4-trifluoromethoxybenzyl group, 2- [2- (bromomethoxy) phenyl ] ethyl group, 1- [3- (2-chloroethoxy) phenyl ] ethyl group, 3- [4- (2, 3-dichloropropoxy) phenyl ] propyl group, 4- [4- (4-fluorobutoxy) phenyl ] butyl group, 5- [3- (5-chloropentyloxy) phenyl ] pentyl group, 6- [4- (5-bromohexyloxy) phenyl ] hexyl group, 1-dimethyl-2- [4- (5, 6-dibromohexyloxy) phenyl ] ethyl group, 3, 4-bis (trifluoromethoxy) benzyl group, 3, 4-bis (4, 4, 4-trichlorobutoxy) benzyl group, methyl group, ethyl group, propyl group, butyl group, pentyl group, hexyl group, 2, 4-bis (3-chloro-2-methoxypropyl) benzyl, 2, 5-bis (3-chloropropoxy) benzyl, 2, 6-bis (2, 2, 2-trifluoroethoxy) benzyl, 3, 4, 5-tris (trifluoromethoxy) benzyl, 4- (2, 2, 2-trichloroethoxy) benzyl, 2-methyl-4-trifluoromethoxybenzyl, 3-ethyl-4-trichloromethoxybenzyl, 2-methoxy-4-trifluoromethoxybenzyl, 3-ethoxy-4-trichloromethoxybenzyl, 2-methyl-3-trifluoromethoxy-4-trifluoromethoxybenzyl, 2-chloro-3-methylbenzyl, 2-chloro-3-trifluoromethylphenyl, 2-chloro-5-trifluoromethylphenyl, 2, 5-bis (3-chloropropoxy) benzyl, 2, 2, 2-bis (2, 2, 2, 2-trifluoroethoxy) benzyl, 3-trifluoromethyl-, 4-fluoro-2-trifluoromethoxybenzyl and 3-chloro-2-methyl-4-methoxybenzyl.

Examples of the phenyl lower alkyl group having a lower alkylenedioxy group as a substituent on the benzene ring include phenylalkyl groups having a linear or branched alkylenedioxy group having 1 to 4 carbon atoms as a substituent on the benzene ring and the alkyl moiety thereof is a linear or branched alkyl group having 1 to 6 carbon atoms, such as 3, 4-methylenedioxybenzyl, 3, 4-trimethylenedioxybenzyl, 2- (2, 3-ethylenedioxyphenyl) ethyl, 1- (3, 4-trimethylenedioxyphenyl) ethyl, 3- (2, 3-tetramethylenedioxyphenyl) propyl, 4- (3, 4-methylenedioxyphenyl) butyl, 5- (2, 3-ethylenedioxyphenyl) pentyl, 6- (3, 4-trimethylenedioxyphenyl) hexyl, 2-tetramethylenedioxyphenyl, 1, 1-dimethyl-2- (2, 3-methylenedioxyphenyl) ethyl and 2-methyl-3- (3, 4-ethylenedioxyphenyl) propyl.

Examples of the amino group which may have a lower alkanoyl group as a substituent include amino groups which may have a straight or branched alkanoyl group having 1 to 6 carbon atoms as a substituent, such as amino, N-acetylamino, N-formylamino, N-propionylamino, N-butyrylamino, N-isobutyrylamino, N-valerylamino, N-tert-butyrylamino and N-hexanoylamino.

Examples of the 1, 2, 3, 4-tetrahydroquinolyl group which may have 1 to 3 substituents selected from an oxy group, a lower alkoxy group and a lower alkylenedioxy group on the tetrahydroquinoline ring include 1, 2, 3, 4-tetrahydroquinolyl groups which may have 1 to 3 substituents selected from an oxy group, a straight or branched alkoxy group having 1 to 6 carbon atoms and a straight or branched alkylenedioxy group having 1 to 4 carbon atoms on the tetrahydroquinoline ring, such as (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl group, 2-oxo- (1, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl group, 2-oxo-6, 7-methylenedioxy- (1, 3, 4, 5 or 8-)1, 2, 3, 4-tetrahydroquinolyl, 4-oxo- (1, 2, 3, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl, 2, 4-dioxo- (1, 3, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl, 2, 4-dioxo-6, 7-methylenedioxy- (1, 3, 5 or 8-)1, 2, 3, 4-tetrahydroquinolyl, 5, 6-ethylenedioxy- (1, 2, 3, 4, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl, 7, 8-trimethylenedioxy- (1, 2, 3, 4, 5 or 6-)1, 2, 3, 4-tetrahydroquinolyl, 6, 7-tetramethylenedioxy- (1, 2, 3, 4-tetrahydroquinolyl), 2. 3, 4, 5 or 8-)1, 2, 3, 4-tetrahydroquinolyl, 5-methoxy-2-oxo- (1, 3, 4, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl and 2-oxo-6, 7-ethylenedioxy- (1, 3, 4, 5 or 8-)1, 2, 3, 4-tetrahydroquinolyl.

Examples of the cycloalkyl lower alkyl group include cycloalkylalkyl groups having 3 to 16 carbon atoms whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as cyclopropylmethyl, cyclohexylmethyl, 2-cyclopropylethyl, 1-cyclobutylethyl, 3-cyclopentylpropyl, 4-cyclohexylbutyl, 5-cycloheptylpentyl, 6-cyclooctylhexyl, 1-dimethyl-2-cyclononylethyl, 2-methyl-3-cyclodecylpropyl, cycloundecylmethyl, 2-cyclododecylethyl, 1-cyclotridecylethyl, 3-cyclotetradecylpropyl, 4-cyclopentadecylbutyl and 5-cyclodecylpentyl.

Examples of pyridyl lower alkyl include pyridylalkyl whose alkyl moiety is a straight or branched chain alkyl having 1 to 6 carbon atoms, such as (2, 3 or 4-) pyridylmethyl, 2- [ (2, 3 or 4-) pyridyl ] ethyl, 1- [ (2, 3 or 4-) pyridyl ] ethyl, 3- [ (2, 3 or 4-) pyridyl ] propyl, 4- [ (2, 3 or 4-) pyridyl ] butyl, 1-dimethyl-2- [ (2, 3 or 4-) pyridyl ] ethyl, 5- [ (2, 3 or 4-) pyridyl ] pentyl, 6- [ (2, 3 or 4-) pyridyl ] hexyl, 1- [ (2, 3 or 4-) pyridyl ] isopropyl and 2-methyl-3- [ (2, 3 or 4-) pyridyl ] isopropyl, 3 or 4-) pyridyl ] propyl.

Examples of the lower alkyl group which may be substituted with an amino group having a substituent selected from the group consisting of a lower alkyl group and a lower alkanoyl group include a straight-chain or branched-chain alkyl group having 1 to 6 carbon atoms and an amino group which may have 1 or 2 substituents selected from the group consisting of a straight-chain or branched-chain alkyl group having 1 to 6 carbon atoms and a straight-chain or branched-chain alkanoyl group having 1 to 6 carbon atoms, such as an aminomethyl group, a 2-aminoethyl group, a 1-aminoethyl group, a 3-aminopropyl group, a 4-aminobutyl group, a 5-aminopentyl group, a 6-aminohexyl group, a 1, 1-dimethyl-2-aminoethyl group, a 2-methyl-3-aminopropyl group, a methylaminomethyl group, a 1-ethylaminoethyl group, a 2-propylaminoethyl group, a 3-isopropylaminopropyl group, a 4-butylaminobutyl group, a 5-pentylaminopentyl, Dimethylaminomethyl group, 2-diisopropylaminoethyl group, (N-ethyl-N-propylamino) methyl group, 2- (N, N-dimethylamino) ethyl group, 2- (N-methyl-N-hexylamino) ethyl group, formylaminomethyl group, acetylaminomethyl group, 1-propionylaminoethyl group, 2-acetylaminoethyl group, 3-butyrylaminopropyl group, 4-valerylaminobutyl group, 5-caproylaminopentyl group, 6-acetylaminohexyl group, N-methyl-N-acetylaminomethyl group, 2- (N-ethyl-N-propionylamino) ethyl group, (N-ethyl-N-butyrylamino) methyl group, 2- (N-methyl-N-caproylamino) ethyl group and 3- (N, n-dimethylamino) propyl.

Examples of the lower alkoxy lower alkyl group include a linear or branched alkyl group having 1 to 6 carbon atoms having a linear or branched alkoxy group having 1 to 6 carbon atoms as a substituent, such as methoxymethyl group, 1-ethoxyethyl group, 2-methoxyethyl group, 2-propoxyethyl group, 3-isopropoxypropyl group, 4-butoxybutyl group, 5-pentyloxypentyl group, 6-hexyloxyhexyl group, 1-dimethyl-2-methoxyethyl group, 2-methyl-3-ethoxypropyl group and 3-methoxypropyl group.

Examples of the 1, 2, 3, 4-tetrahydroisoquinolinylcarbonyl-substituted lower alkyl group include a 1, 2, 3, 4-tetrahydroisoquinolinylcarbonylalkyl group whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroisoquinolinylcarbonylmethyl group, 2- [ (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroisoquinolinylcarbonyl ] ethyl group, 1- [ ((1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroisoquinolinylcarbonyl ] ethyl group, 3- [ (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroisoquinolinylcarbonyl ] propyl group, 1, 2, 3, 4-tetrahydroisoquinolinylcarbonyl group, 4- [ (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroisoquinolinylcarbonyl ] butyl, 1-dimethyl-2- [ (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroisoquinolinylcarbonyl ] ethyl, 5- [ (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroisoquinolinylcarbonyl ] pentyl, 6- [ (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroisoquinolinylcarbonyl ] hexyl, 1- [ (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroisoquinolinylcarbonyl ] isopropyl and 2-methyl-3- [ (1, 2, 3, 4-), 2. 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroisoquinolinylcarbonyl ] propyl.

Examples of the piperidinylcarbonyl group which may have a substituent(s) on the piperidine ring selected from the group consisting of a lower alkoxycarbonyl group, a phenyllower alkyl group and a furanyl lower alkyl group include an alkoxycarbonyl group which may have a substituent(s) on the piperidine ring selected from the group consisting of an alkoxycarbonyl group whose alkoxy moiety is a linear or branched alkoxy group having 1 to 6 carbon atoms, a phenylalkyl group whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms and a furanylalkyl group whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as a piperidinylcarbonyl group (1, 2, 3 or 4-) phenylmethyl- (2, 3 or 4-) piperidinylcarbonyl group, a 1- (2 or 3-) furanylmethyl- (2, 3 or 4-) piperidinylcarbonyl group, a 1- (2-phenylethyl) - (2, a, 3 or 4-) piperidinylcarbonyl, 1- {2- [ (1 or 2-) furyl ] ethyl } - (2, 3 or 4-) piperidinylcarbonyl, 1- (1-phenylethyl) - (2, 3 or 4-) piperidinylcarbonyl, 1- {3- [ (1 or 2-) furyl ] propyl ] } - (2, 3 or 4-) piperidinylcarbonyl, 1- (3-phenylpropyl) - (2, 3 or 4-) piperidinylcarbonyl, 1- {1- [ (1 or 2-) furyl ] ethyl ] } - (2, 3 or 4-) piperidinylcarbonyl, 1- (4-phenylbutyl) - (2, 3 or 4-) piperidinylcarbonyl, 1- {4- [ (1 or 2-) furyl ] butyl ] } - (2, 3 or 4-) furyl ] butyl ] }, 2- (2) piperidylcarbonyl, or a salt thereof, 3 or 4-) piperidinylcarbonyl, 1- (5-phenylpentyl) - (2, 3 or 4-) piperidinylcarbonyl, 1- {5- [ (1 or 2-) furyl ] pentyl ] } - (2, 3 or 4-) piperidinylcarbonyl, 1- (6-phenylhexyl) - (2, 3 or 4-) piperidinylcarbonyl, 1- {6- [ (1 or 2-) furyl ] hexyl ] } - (2, 3 or 4-) piperidinylcarbonyl, 1, 2-benzhydryl- (3, 4, 5 or 6-) piperidinylcarbonyl, 1, 3-bis (1 or 2-) furylmethyl- (2, 4, 5 or 6-) piperidinylcarbonyl, 1, 3, 5-trityl- (2, 5, 4-or 6-) piperidinylcarbonyl, 1, 3, 5-trityl- (2, 4, 5 or 6-) piperidinylcarbonyl, 1, 3, 4 or 6-) piperidinylcarbonyl, 1, 2, 6-tris (1 or 2-) furylmethyl- (3, 4 or 5-) piperidinylcarbonyl, 1-benzyl-3- (1 or 2-) furylmethyl- (2, 4, 5 or 6-) piperidinylcarbonyl, 1- {1- [ (1 or 2-) furyl ] ethyl ] } - (2, 3 or 4-) piperidinylcarbonyl, 1-methoxycarbonyl- (2, 3 or 4-) piperidinylcarbonyl, 1-ethoxycarbonyl- (2, 3 or 4-) piperidinylcarbonyl, 1-propoxycarbonyl- (2, 3 or 4-) piperidinylcarbonyl, 1-butoxycarbonyl- (2, 3 or 4-) piperidinylcarbonyl, 1-tert-butoxycarbonyl- (2, 5 or 5-) piperidinylcarbonyl, 3 or 4-) piperidinylcarbonyl, 1-pentyloxycarbonyl- (2, 3 or 4-) piperidinylcarbonyl, 1-hexyloxycarbonyl- (2, 3 or 4-) piperidinylcarbonyl, 1, 2-dimethoxycarbonyl- (3, 4, 5 or 6-) piperidinylcarbonyl, 1, 2, 6-triethoxycarbonyl- (3, 4 or 5-) piperidinylcarbonyl, 1- (1 or 2-) furylmethyl-3-tert-butoxycarbonyl- (3, 4, 5 or 6-) piperidinylcarbonyl, 1-benzyl-2-methoxycarbonyl- (2, 4, 5 or 6-) piperidinylcarbonyl and 1- (1 or 2-) furylmethyl-2, 4-dimethoxycarbonyl- (3, 4-dimethoxycarbonyl, 5 or 6-) piperidinylcarbonyl.

Examples of the thiazolidinyl lower alkanoyl group which may have an oxy group as a substituent on the thiazolidine ring include thiazolidinyl alkanoyl groups which may have 1 to 3 oxy groups as substituents on the thiazolidine ring and whose alkanoyl moiety is a straight-chain or branched alkanoyl group having 2 to 6 carbon atoms, such as 2- [ (2, 3, 4 or 5-) thiazolidinyl ] acetyl, 3- [ (2, 3, 4 or 5-) thiazolidinyl ] propionyl, 2- [ (2, 3, 4 or 5-) thiazolidinyl ] propionyl, 4- [ (2, 3, 4 or 5-) thiazolidinyl ] butyryl, 5- [ (2, 3, 4 or 5-)1, 2, 4-thiazolidinyl ] pentanoyl, 6- [ (2, 3, 4 or 5-) thiazolidinyl ] hexanoyl, 2-dimethyl-3- [ (2, 3, 4 or 5-) thiazolidinyl ] hexanoyl, 3. 4 or 5-) thiazolidinyl ] propionyl, 2-methyl-3- [ (2, 3, 4 or 5-) thiazolidinyl ] propionyl, 2, 4-dioxo- (3 or 5-) thiazolidinyl acetyl, 3- [ 2-oxo- (3, 4 or 5-) thiazolidinyl ] propionyl, 2- [ 4-oxo- (2, 3 or 5-) thiazolidinyl ] propionyl, 4- [ 5-oxo- (2, 3 or 4-) thiazolidinyl ] butyryl, 5- [2, 5-dioxo- (3 or 4-) thiazolidinyl ] pentanoyl, 6- [2, 4, 5-trioxo-3-thiazolidinyl ] hexanoyl, 2- [4, 5-dioxo- (2 or 3-) thiazolidinyl ] acetyl, thiazolidinyl, and mixtures thereof, 2, 2-dimethyl-3- [2, 4-dioxo- (3 or 5-) thiazolidinyl ] propionyl and 2-methyl-3- [2, 4-dioxo- (3 or 5-) thiazolidinyl ] propionyl.

Examples of the piperidyl group which may be substituted on the piperidine ring by a group selected from the group consisting of a lower alkoxycarbonyl group, a phenyl lower alkyl group, a benzoyl group and a furyl lower alkyl group include piperidyl groups which may be substituted on the piperidine ring by 1 to 3 groups selected from the group consisting of an alkoxycarbonyl group whose alkoxy moiety is a linear or branched alkoxy group having 1 to 6 carbon atoms, a phenylalkyl group whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, a benzoyl group and a furyl alkyl group whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as (1, 2, 3 or 4-) piperidyl, 1-benzyl- (2, 3 or 4-) piperidyl, 1- (2 or 3-) furyl methyl- (2, 3 or 4-) piperidyl, 1- (2-phenylethyl) - (2, 3 or 4-) piperidinyl, 1- {2- [ (1 or 2-) furanyl ] ethyl } - (2, 3 or 4-) piperidinyl, 1- (1-phenylethyl) - (2, 3 or 4-) piperidinyl, 1- {3- [ (1 or 2-) furanyl ] propyl ] } - (2, 3 or 4-) piperidinyl, 1- (3-phenylpropyl) - (2, 3 or 4-) piperidinyl, 1- {1- [ (1 or 2-) furanyl ] ethyl ] } - (2, 3 or 4-) piperidinyl, 1- (4-phenylbutyl) - (2, 3 or 4-) piperidinyl, 1- {4- [ (1 or 2-) furanyl ] butyl ] } - (2, 4-) 3. Or 4-) piperidinyl, 1- (5-phenylpentyl) - (2, 3 or 4-) piperidinyl, 1- {5- [ (1 or 2-) furanyl ] pentyl ] } - (2, 3 or 4-) piperidinyl, 1- (6-phenylhexyl) - (2, 3 or 4-) piperidinyl, 1- {6- [ (1 or 2-) furanyl ] hexyl ] } - (2, 3 or 4-) piperidinyl, 1, 2-benzhydryl- (3, 4, 5 or 6-) piperidinyl, 1, 3-bis (1 or 2-) furanylmethyl- (2, 4, 5 or 6-) piperidinyl, 1, 3, 5-trityl- (2, 4 or 6-) piperidinyl, 1, 2, 6-tris (1 or 2-) furylmethyl- (3, 4 or 5-) piperidinyl, 1-benzyl-3- (1 or 2-) furylmethyl- (2, 4, 5 or 6-) piperidinyl, 1- {1- [ (1 or 2-) furyl ] ethyl ] } - (2, 3 or 4-) piperidinyl, 1-benzoyl- (2, 3 or 4-) piperidinyl, 1, 2-dibenzoyl- (3, 4, 5 or 6-) piperidinyl, 1, 3, 5-tribenzoyl- (2, 4 or 6-) piperidinyl, 1-methyl- (2, 3 or 4-) piperidinyl, 1-ethyl- (2, 3 or 4-) piperidinyl, piperidinyl, 1-propyl- (2, 3 or 4-) piperidinyl, 1-isopropyl- (2, 3 or 4-) piperidinyl, 1-butyl- (2, 3 or 4-) piperidinyl, 1-isobutyl- (2, 3 or 4-) piperidinyl, 1-tert-butyl- (2, 3 or 4-) piperidinyl, 1-pentyl- (2, 3 or 4-) piperidinyl, 1-hexyl- (2, 3 or 4-) piperidinyl, 1, 2-dimethyl- (3, 4, 5 or 6-) piperidinyl, 1, 2, 6-trimethyl- (3, 4 or 5-) piperidinyl, 1-methyl-3-benzyl- (3, 4, 5 or 6-) piperidinyl, 1-benzoyl-2-methyl- (2, 4-) piperidinyl, 4. 5 or 6-) piperidinyl, 1- (1 or 2-) furylmethyl-2, 4-dimethyl- (3, 5 or 6-) piperidinyl, 1-methoxycarbonyl- (2, 3 or 4-) piperidinyl, 1-ethoxycarbonyl- (2, 3 or 4-) piperidinyl, 1-propoxycarbonyl- (2, 3 or 4-) piperidinyl, 1-butoxycarbonyl- (2, 3 or 4-) piperidinyl, 1-tert-butoxycarbonyl- (2, 3 or 4-) piperidinyl, 1-pentoxycarbonyl- (2, 3 or 4-) piperidinyl, 1-hexoxycarbonyl- (2, 3 or 4-) piperidinyl, 1, 2-dimethoxycarbonyl- (3, 4, 5 or 6-) piperidinyl, 1-dimethoxycarbonyl- (3, 4, 5 or 6-) piperidinyl, 1, 2, 6-triethoxycarbonyl- (3, 4 or 5-) piperidinyl, 1-methyl-3-tert-butoxycarbonyl- (3, 4, 5 or 6-) piperidinyl, 1-benzoyl-2-methoxycarbonyl- (2, 4, 5 or 6-) piperidinyl, 1- (1 or 2-) furylmethyl-2, 4-dimethoxycarbonyl- (3, 5 or 6-) piperidinyl and 1-benzyl-2, 4-dimethoxycarbonyl- (3, 5 or 6-) piperidinyl.

By using

[ general formula 54]

Examples of the group (hereinafter referred to as "A group") substituted carbonyl lower alkyl group of (A) include A group-substituted carbonylalkyl groups whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as an A group-substituted carbonylmethyl group, a 2-A group-substituted carbonylethyl group, a 1-A group-substituted carbonylethyl group, a 3-A group-substituted carbonylpropyl group, a 4-A group-substituted carbonylbutyl group, a 1, 1-dimethyl-2-A group-substituted carbonylethyl group, a 5-A group-substituted carbonylpentyl group, a 6-A group-substituted carbonylhexyl group, a 1-A group-substituted carbonylisopropyl group and a 2-methyl-3-A group-substituted carbonylpropyl group.

By using

[ general formula 55]

Group (wherein, R)³⁴An oxo group or a phenyl group, and d is an integer of 0 to 3, hereinafter referred to as "B group") includes a B group-substituted carbonylalkyl group in which the alkyl moiety is a straight or branched alkyl group having 1 to 6 carbon atomsFor example, a carbonylmethyl group substituted with a group B, a carbonylethyl group substituted with a group 2-B, a carbonylethyl group substituted with a group 1-B, a carbonylpropyl group substituted with a group 3-B, a carbonylbutyl group substituted with a group 4-B, a carbonylethyl group substituted with a group 1, 1-dimethyl-2-B, a carbonylpentyl group substituted with a group 5-B, a carbonylhexyl group substituted with a group 6-B, a carbonylisopropyl group substituted with a group 1-B and a carbonylpropyl group substituted with a group 2-methyl-3-B.

Examples of pyrrolidinyl lower alkyl groups include pyrrolidinyl alkyl groups wherein the alkyl moiety is a straight or branched alkyl group having 1 to 6 carbon atoms, such as (1-, 2-or 3-) pyrrolidinylmethyl, 2- [ (1-, 2-or 3-) pyrrolidinyl ] ethyl, 1- [ (1-, 2-or 3-) pyrrolidinyl ] ethyl, 3- [ (1-, 2-or 3-) pyrrolidinyl ] propyl, 4- [ (1-, 2-or 3-) pyrrolidinyl ] butyl, 5- [ (1-, 2-or 3-) pyrrolidinyl ] pentyl, 6- [ (1-, 2-or 3-) pyrrolidinyl ] hexyl, 1-dimethyl-2- [ (1- 2-or 3-) pyrrolidinyl ] ethyl and 2-methyl-3- [ (1-, 2-or 3-) pyrrolidinyl ] propyl.

Examples of morpholinyl lower alkyl include morpholinyl alkyl whose alkyl moiety is a straight-chain or branched alkyl having 1 to 6 carbon atoms, such as (2-, 3-or 4-) morpholinylmethyl, 2- [ (2-, 3-or 4-) morpholinyl ] ethyl, 1- [ (2-, 3-or 4-) morpholinyl ] ethyl, 3- [ (2-, 3-or 4-) morpholinyl ] propyl, 4- [ (2-, 3-or 4-) morpholinyl ] butyl, 5- [ (2-, 3-or 4-) morpholinyl ] pentyl, 6- [ (2-, 3-or 4-) morpholinyl ] hexyl, 1-dimethyl-2- [ (2-, 4- ] 3-or 4-) morpholinyl ] ethyl and 2-methyl-3- [ (2-, 3-or 4-) morpholinyl ] propyl.

Examples of the phenyl lower alkenyl group include phenylalkenyl groups whose alkenyl moiety is a straight-chain or branched-chain alkenyl group having 2 to 6 carbon atoms and having 1 to 3 double bonds, such as styryl, 3-phenyl-2-propenyl (common name: cinnamyl), 4-phenyl-2-butenyl, 4-phenyl-3-butenyl, 5-phenyl-4-pentenyl, 5-phenyl-3-pentenyl, 6-phenyl-5-hexenyl, 6-phenyl-4-hexenyl, 6-phenyl-3-hexenyl, 4-phenyl-1, 3-butadienyl and 6-phenyl-1, 3, 5-hexanetrienyl.

Examples of the anilinocarbonyl lower alkyl group which may have a lower alkyl group as a substituent on the benzene ring include anilinocarbonylalkyl groups whose alkyl moiety is a straight-chain or branched-chain alkyl group having 1 to 6 carbon atoms and which may have 1 to 3 straight-chain or branched-chain alkyl groups having 1 to 6 carbon atoms as substituents on the benzene ring, such as anilinocarbonylmethyl, 2-anilinocarbonylethyl, 1-anilinocarbonylethyl, 3-anilinocarbonylpropyl, 4-anilinocarbonylbutyl, 5-anilinocarbonylpentyl, 6-anilinocarbonhexylyl, 1-dimethyl-2-anilinocarbonylethyl, 2-methyl-3-anilinocarbonylpropyl, (4-methylanilinocarbonyl) methyl, 2- (3-methylanilinocarbonyl) ethyl, 3- (4-methylanilinocarbonyl) propyl group, 1- (2-ethylanilinocarbonyl) ethyl group, 4- (3-ethylanilinocarbonyl) butyl group, 5- (4-ethylanilinocarbonyl) pentyl group, 6- (4-isopropylanilinocarbonyl) hexyl group, 1-dimethyl-2- (3-butylanilinocarbonyl) ethyl group, 2-methyl-3- (4-pentylanilinocarbonyl) propyl group, 4-hexylanilinocarbonylmethyl group, 3, 4-dimethylanilinocarbonylmethyl group, 3, 4-diethylanilinocarbonylmethyl group, 2, 4-dimethylanilinocarbonylmethyl group, 2, 5-dimethylanilinocarbonylmethyl group, 2, 6-dimethylanilinocarbonylmethyl group and 3, 4, 5-trimethylanilinocarbonylmethyl.

Examples of the piperazinyl lower alkyl group which may have a substituent selected from the group consisting of a lower alkyl group and a phenyl lower alkyl group which may have a lower alkylenedioxy group as a substituent on the benzene ring include a piperazinyl alkyl group whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms and which may have 1 to 3 substituents selected from the group consisting of a straight-chain or branched alkyl group having 1 to 6 carbon atoms and a phenylalkyl group which may have a straight-chain or branched alkylenedioxy group containing 1 to 4 carbon atoms as a substituent on the benzene ring and whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as [ (1-, 2-or 3-) piperazinyl ] methyl, 2- [ (1-, 2-or 3-) piperazinyl ] ethyl, 1- [ (1-, 2-or 3-) piperazinyl ] ethyl, piperazinyl, 3- [ (1-, 2-or 3-) piperazinyl ] propyl, 4- [ (1-, 2-or 3-) piperazinyl ] butyl, 5- [ (1-, 2-or 3-) piperazinyl ] pentyl, 6- [ (1-, 2-or 3-) piperazinyl ] hexyl, 1-dimethyl-2- [ (1-, 2-or 3-) piperazinyl ] ethyl, 2-methyl-3- [ (1-, 2-or 3-) piperazinyl ] propyl, [ 1-methyl- (2-, 3-or 4-) piperazinyl ] methyl, 2- [ 1-ethyl- (2-, 3-or 4-) piperazinyl ] ethyl, methyl, ethyl, propyl, pentyl, 1- [ 4-propyl- (1-, 2-or 3-) piperazinyl ] ethyl, 3- [ 3-isopropyl- (1-, 2-, 4-, 5-or 6-) piperazinyl ] propyl, 4- [ 2-butyl- (1-, 3, 4-, 5-or 6-) piperazinyl ] butyl, 5- [ 1-isobutyl- (2-, 3-or 4-) piperazinyl ] pentyl, 3- [ 4-methyl- (1-, 2-or 3-) piperazinyl ] propyl, 6- [ 1-tert-butyl- (2-, 3-or 4-) piperazinyl ] hexyl, 1-dimethyl-2- [ 4-pentyl- (1- 2-or 3-) piperazinyl ] ethyl, [1, 2-dimethyl- (3-, 4-, 5-or 6-) piperazinyl ] methyl, [1, 2, 6-trimethyl- (3-, 4-or 5-) piperazinyl ] methyl and 2- [4- (3, 4-methylenedioxybenzyl) - (1-, 2-or 3-) piperazinyl ] ethyl.

Examples of the amidinoalkyl group which may have a lower alkyl group as a substituent include amidinoalkyl groups whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms and which may have 1 or 2 straight-chain or branched alkyl groups containing 1 to 6 carbon atoms, such as amidinoalkyl, 2-amidinoaethyl, 1-amidinoaethyl, 3-amidinoapropyl, 4-amidinoabutyl, 5-amidinoapentyl, 6-amidinoahexyl, 1-dimethyl-2-amidinoaethyl, 2-methyl-3-amidinoapropyl, N-dimethylaminomethyl, 2- (N, N-dimethylaminoalkyl) ethyl, 1- (N-methylamidino) ethyl, 3- (N-ethylamidino) propyl, 4- (N-N-propylamidino) propyl, 5- (N-N-pentylamidino) pentyl, 6- (N-N-hexylamidino) hexyl and (N-methyl-N-ethylamidino) methyl.

Examples of the carbazolyl group which may have a lower alkyl group as a substituent on the carbazole ring include carbazolyl groups which may have 1 to 3 straight-chain or branched alkyl groups having 1 to 6 carbon atoms as substituents on the carbazole ring, such as (1-, 2-, 3-or 4-) carbazolyl, 9-methyl- (1-, 2-, 3-or 4-) carbazolyl, 9-ethyl- (1-, 2-, 3-or 4-) carbazolyl, 1-ethyl- (2-, 3-, 4-, 5-, 6-, 7-, 8-or 9-) carbazolyl, 2-n-propyl- (1-, 3-, 4-, 5-, 6-, 8-or 9-) carbazolyl, carbazolyl, 3-n-butyl- (1-, 2-, 4-, 5-, 6-, 7-, 8-or 9-) carbazolyl, 4-n-pentyl- (1-, 2-, 3-, 5-, 6-, 7-, 8-or 9-) carbazolyl, 5-n-hexyl- (1-, 2-, 3-, 4-, 6-, 7-, 8-or 9-) carbazolyl, 6, 9-dimethyl- (1-, 2-, 3-, 4-, 5-, 7-or 8-) carbazolyl and 1, 7, 8-trityl- (2-, 3-, 4-, 5-, 6-), Or 9-) carbazolyl.

Examples of the amidino group which may have a lower alkyl group as a substituent include amidino groups which may have 1 or 2 linear or branched alkyl groups containing 1 to 6 carbon atoms as a substituent, such as amidino group, N-dimethylaminoamidino group, N-methylamidino group, N-ethylamidino group, N-N-propylamidino group, N-N-butylamidino group, N-N-pentylamidino group, N-N-hexylamidino group, N-diethylamidino group and N-methyl-N-ethylamidino group.

Examples of the phenyl lower alkyl group (which may have 1 to 3 substituents selected from the group consisting of a lower alkylenedioxy group and a lower alkoxy group on the benzene ring) include, in addition to the above-mentioned phenyl lower alkyl group, a phenylalkyl group whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms (and which may have 1 to 3 substituents selected from the group consisting of a linear or branched alkylenedioxy group having 1 to 4 carbon atoms and a linear or branched alkoxy group having 1 to 6 carbon atoms on the benzene ring), such as 3, 4-methylenedioxybenzyl group, 3, 4-trimethylenedioxybenzyl group, 2- (2, 3-ethylenedioxyphenyl) ethyl group, 1- (3, 4-trimethylenedioxyphenyl) ethyl group, 3- (2, 3-tetramethylenedioxyphenyl) propyl group, 4- (3, 4-methylenedioxyphenyl) butyl, 5- (2, 3-ethylenedioxyphenyl) pentyl, 6- (3, 4-trimethylenedioxyphenyl) hexyl, 1-dimethyl-2- (2, 3-methylenedioxyphenyl) ethyl, 2-methyl-3- (3, 4-ethylenedioxyphenyl) propyl, 2-methoxybenzyl, 2- (2-methoxyphenyl) ethyl, 2- (3-methoxyphenyl) ethyl, 2- (4-methoxyphenyl) ethyl, 4-methoxybenzyl, 1- (2-ethoxyphenyl) ethyl, 3- (3-ethoxyphenyl) propyl, 4- (4-ethoxyphenyl) butyl, 5- (4-isopropoxyphenyl) pentyl, 2- (3-ethoxyphenyl) hexyl, 2- (2-methylethoxyphenyl) pentyl, 2-methyl-ethyl, 4-ethoxyphenyl) propyl, 4- (4-ethoxyphenyl) butyl, 5- (4-isopropoxyphenyl) pentyl, 2-methyl-ethyl, 2-methyl-3, 6- (3-butoxyphenyl) hexyl, 1-dimethyl-2- (4-pentyloxyphenyl) ethyl, 2-methyl-3- (4-hexyloxyphenyl) propyl, 3, 4-dimethoxybenzyl, 3, 4-diethoxybenzyl, 2, 4-dimethoxybenzyl, 2, 5-dimethoxybenzyl, 2, 6-dimethoxybenzyl, and 3, 4, 5-trimethoxybenzyl.

The piperazinyl-substituted oxalyl group which may have 1 to 3 substituents selected from phenyl lower alkyl (which may have 1 to 3 substituents selected from lower alkylenedioxy and lower alkoxy on the benzene ring) and pyridyl lower alkyl on the piperazine ring includes a piperazinyl-substituted oxalyl group which may have 1 to 3 substituents selected from phenylalkyl (which may have 1 to 3 substituents selected from straight-chain or branched-chain alkylenedioxy having 1 to 4 carbon atoms and straight-chain or branched-chain alkoxy having 1 to 6 carbon atoms on the benzene ring) whose alkyl moiety is straight-chain or branched-chain alkyl having 1 to 6 carbon atoms and pyridylalkyl whose alkyl moiety is straight-chain or branched-chain alkyl having 1 to 6 carbon atoms on the benzene ring, such as 4- (3, 4-methylenedioxybenzyl) - (1-methylenedioxybenzyl), 2-or 3-) piperazinoxalyl, 4- (2-, 3-or 4-pyridylmethyl) - (1-, 2-or 3-) piperazinoxalyl, 4- (3, 4-dimethoxybenzyl) - (1-, 2-or 3-) piperazinoxalyl, 4- (2, 3-methylenedioxybenzyl) - (1-, 2-or 3-) piperazinoxalyl, 4- (3, 4-ethylenedioxybenzyl) - (1-, 2-or 3-) piperazinoxalyl, 4- [2- (2-, 3-or 4-pyridyl) ethyl ] - (1-, 2-or 3-) piperazinoxalyl, and mixtures thereof, 4- [3- (2-, 3-or 4-pyridyl) propyl- (1-, 2-or 3-) piperazinoxalyl, 2, 4-bis (2-, 3-or 4-pyridylmethyl) - (1-, 2-or 3-) piperazinoxalyl, 2- (3, 4-methylenedioxybenzyl) -4- (2-, 3-or 4-pyridylmethyl) - (1-, 2-or 3-) piperazinoxalyl and 2, 3, 4-tris (2-, 3-or 4-pyridylmethyl) - (1-, 2-or 3-) piperazinoxalyl.

Examples of the cyano-substituted lower alkyl group include cyanoalkyl groups whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as cyanomethyl, 2-cyanoethyl, 1-cyanoethyl, 3-cyanopropyl, 4-cyanobutyl, 5-cyanopentyl, 6-cyanohexyl, 1-dimethyl-2-cyanoethyl and 2-methyl-3-cyanopropyl.

From R³⁶And R³⁷Examples of the 5 to 7-membered saturated heterocyclic ring which may be formed by connecting each other together with the nitrogen atom to which they are attached with or without a nitrogen atom, an oxygen atom or a sulfur atom include pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl and homopiperazinyl.

R¹⁴And R¹⁵Examples of the 5-to 10-membered saturated or unsaturated heterocyclic ring which may be connected to each other with or without a nitrogen atom, an oxygen atom or a sulfur atom together with the nitrogen atom to which they are bonded include 1, 2, 3, 4, 5, 6-hexahydropyrimidyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperazinyl, homopiperidinyl, thiazolidinyl, 1, 2, 5, 6-tetrahydropyridinyl, pyrrolyl, pyrazolyl, imidazolyl, 2-pyrrolinyl, 2-imidazolinyl, imidazolidinyl, 2-pyrazolinyl, pyrazolidinyl, 1, 2-dihydropyridinyl, 1, 2-dihydroquinolinyl, 1, 2, 3, 4-tetrahydroquinolinyl, 1, 2, 3, 4-tetrahydroisoquinolinyl, 1, 2-dihydroisoquinolinyl, indolyl, isoindolyl, indolinyl, Isoindoline, 3, 4-dihydro-2H-1, 4-benzoxazinyl, 3, 4-dihydro-2H-1, 4-benzothiazolyl, 1, 4-benzothiazinyl, 1, 2, 3, 4-tetrahydroquinoxalinyl, 1, 2, 3, 4-tetrahydrocinnolinyl, 1, 2, 3, 4-tetrahydronaphthyridinyl, 1, 2, 3, 4-tetrahydroquinazolinyl, 1, 2-dihydroquinoxalinyl, 3, 4-dihydroquinoxalinyl, 1, 2-dihydrocinnolinyl, 1, 2-dihydronaphthyridinyl, 3, 4-dihydronaphthyridinyl, 1, 2-dihydroquinazolinyl, 3, 4-dihydroquinazolinyl, indazolyl (indazolinyl), 6-azabicyclo [3, 2, 1 ] rings ]Octyl, 3-aza-spiro [5, 5 ]]Undecyl and thiazolidinyl. Preferably, R¹⁴And R¹⁵Are linked to each other directly or through a nitrogen atom and together with the nitrogen atom to which they are linked form a 6-membered saturated heterocyclic group. Most preferably, it includes piperidinyl and piperazinyl.

Examples of the phenyl lower alkoxy group include phenylalkoxy groups whose alkoxy moiety is a linear or branched alkoxy group having 1 to 6 carbon atoms, such as benzyloxy, 2-phenylethoxy, 1-phenylethoxy, 3-phenylpropoxy, 4-phenylbutoxy, 5-phenylpentoxy, 6-phenylhexyloxy, 1-dimethyl-2-phenylethoxy and 2-methyl-3-phenylpropoxy.

Examples of the lower alkyl group which has 1 or 2 phenyl groups which may be substituted on the benzene ring by 1 to 3 substituents selected from the group consisting of a lower alkanoyl group, an amino group which may have a lower alkanoyl group as a substituent, a lower alkoxycarbonyl group, a cyano group, a nitro group, a phenyl group, a halogen atom, a lower alkyl group which may have a halogen atom as a substituent, a lower alkoxy group which may have a halogen atom as a substituent, a phenyl lower alkoxy group, a hydroxyl group and a lower alkylenedioxy group and which may have a pyridyl group on the lower alkyl group include, in addition to the above phenyl lower alkyl group, an amino group which has 1 or 2 substituents which may be substituted on the benzene ring by a straight-chain or branched-chain alkanoyl group selected from the group consisting of 1 to 6 carbon atoms, an amino group which may have 1 or 2 straight-chain or branched-chain alkanoyl groups containing 1 to 6 carbon atoms as a substituent, an alkoxycarbonyl group whose alkoxy group is a straight-chain or branched-chain alkoxy group having 1, Cyano, nitro, phenyl, halogen atom, straight or branched chain alkyl group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as substituents, straight or branched chain alkoxy group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as substituents, phenylalkoxy group whose alkoxy group moiety is straight or branched chain alkoxy group having 1 to 6 carbon atoms, phenyl group substituted with 1 to 3 substituents of hydroxyl group and straight or branched chain alkylenedioxy group having 1 to 4 carbon atoms and which may have pyridyl group on the alkyl group, phenyl-substituted alkyl group whose alkyl moiety is straight or branched chain alkyl group having 1 to 6 carbon atoms, such as 1-phenyl-1- (2, 3 or 4-) pyridylmethyl, 1-diphenylmethyl, 1-bis (4-fluorophenyl) methyl, 1-phenyl-1- (4-methoxyphenyl) methyl group, 3, 4-methylenedioxybenzyl group, 3, 4-ethylenedioxybenzyl group, 3, 4-trimethylenedioxybenzyl group, 2, 5-difluorobenzyl group, 2, 4-difluorobenzyl group, 3, 5-difluorobenzyl group, 2, 6-difluorobenzyl group, 3-trifluoromethylbenzyl group, 2-trifluoromethylbenzyl group, 4-trifluoromethylbenzyl group, 3, 4-dimethoxybenzyl group, 3, 5-dimethoxybenzyl group, 2-chlorophenylmethyl group, 3-chlorophenylmethyl group, 4-chlorophenylmethyl group, 2-methylphenylmethyl group, 3-methylphenylmethyl group, 4-methylphenylmethyl group, 3, 4-dimethylphenylmethyl group, 3, 4-dimethoxybenzyl group, 3, 5-dimethoxybenzyl group, 2-chlorophenylmethyl group, 3-chlorophenylmethyl group, 4-chlorophenylmethyl group, 2-methylphenylmethyl group, 3-methylphenylmethyl group, 4, 2, 3-dimethylbenzyl group, 2-methoxybenzyl group, 3-methoxybenzyl group, 4-cyanobenzyl group, 2-cyanobenzyl group, 3-cyanobenzyl group, 4-methoxybenzyl group, 2, 3-dichlorobenzyl group, 2, 4-dichlorobenzyl group, 2, 5-dichlorobenzyl group, 3, 4-dichlorobenzyl group, 2, 6-dichlorobenzyl group, 4-fluorobenzyl group, 3-fluorobenzyl group, 2-fluorobenzyl group, 4-nitrobenzyl group, 3-nitrobenzyl group, 2-nitrobenzyl group, 3-trifluoromethoxybenzyl group, 4-trifluoromethoxybenzyl group, 2-trifluoromethoxybenzyl group, 4-methoxycarbonylbenzyl group, 3-methoxycarbonylbenzyl group, 4-tert-butylbenzyl group, 4-ethylbenzyl, 4-isopropylbenzyl, 4-methoxy-3-chlorophenylmethyl, 2- (4-methoxyphenyl) ethyl, 2- (4-fluorophenyl) ethyl, 2- (4-chlorophenyl) ethyl, 2- (3-methoxyphenyl) ethyl, 2- (4-methylphenyl) ethyl, 4-phenylbenzyl, 3-diphenylpropyl, 3-methyl-4-nitrobenzyl, 4- (4-methoxyphenyl) butyl, 2- (4-methylphenyl) ethyl, 4-tert-butoxycarbonylbenzyl, 3-chloro-6-methoxybenzyl, 4-acetamido-benzyl, 4-nitro-3-methylbenzyl, methyl-ethyl, ethyl-benzyl, 4-hydroxybenzyl group, 3-hydroxybenzyl group, 2-hydroxybenzyl group, 4-tert-butyrylphenyl methyl group, 4-benzyloxybenzyl group, 4-pivaloylphenyl methyl group, 2- (4-acetylphenyl) ethyl group, 1- (3-propionylphenyl) ethyl group, 3- (2-butyrylphenyl) propyl group, 4- (4-valerylphenyl) butyl group, 5- (3-hexanoylphenyl) pentyl group, 6- (2, 4-diacetylphenyl) hexyl group, 1-dimethyl-2- (2, 4, 6-triacetylphenyl) ethyl group, 2-methyl-3- (3, 4-diacetylphenyl) propyl group, 2- (4-aminophenyl) ethyl group, methyl group, ethyl group, isopropyl group, 1- (3-propionylaminophenyl) ethyl, 3- (2-butyrylaminophenyl) propyl, 4- (4-pentanoylamino) phenylbutyl, 5- (hexanoylaminophenyl) pentyl, 6- (N-acetyl-N-propionylaminophenyl) hexyl, 1-dimethyl-2- (3, 4-diaminophenyl) ethyl, 2-methyl-3- (3, 4, 5-triacetylphenyl) propyl, 2- (2-ethoxycarbonylphenyl) ethyl, 1- (3-propoxycarbonylphenyl) ethyl, 3- (4-pentoxycarbonylphenyl) propyl, 4- (3-hexoxycarbonylphenyl) butyl, 5- (3, 4-dimethoxycarbonylphenyl) pentyl, N-butyl, N-, 6- (3, 4, 5-Trioxycarbonylphenyl) hexyl, 1-dimethyl-2- (4-butoxycarbonylphenyl) ethyl, 2-methyl-3- (4-methoxycarbonylphenyl) propyl, 2- (2-cyanophenyl) ethyl, 1- (3-cyanophenyl) ethyl, 3- (4-cyanophenyl) propyl, 4- (2-cyanophenyl) butyl, 5- (3-cyanophenyl) pentyl, 6- (4-cyanophenyl) hexyl, 1-dimethyl-2- (2, 4-dicyanophenyl) ethyl, 2-methyl-3- (2, 4, 6-tricyanophenyl) propyl, 2- (2-nitrophenyl) ethyl, 1-dimethyl-2- (2, 4-dicyanophenyl) ethyl, 1, 4-di-methyl-3- (2, 4, 6-tricyanophenyl) propyl, 2- (2-nitrophenyl) ethyl, 2-, 1- (3-nitrophenyl) ethyl group, 3- (4-nitrophenyl) propyl group, 4- (2-nitrophenyl) butyl group, 5- (3-nitrophenyl) pentyl group, 6- (4-nitrophenyl) hexyl group, 1-dimethyl-2- (2, 4-dinitrophenyl) ethyl group, 2-methyl-3- (2, 4, 6-trinitrophenyl) propyl group, 2- (2-phenylphenyl) ethyl group, 1- (3-phenylphenyl) ethyl group, 3- (4-phenylphenyl) propyl group, 4- (2-phenylphenyl) butyl group, 5- (3-phenylphenyl) pentyl group, 6- (4-phenylphenyl) hexyl group, 1-dimethyl-2- (2), 4-diphenylphenyl) ethyl group, 2-methyl-3- (2, 4, 6-triphenylphenyl) propyl group, 2- (2-fluorophenyl) ethyl group, 1- (3-bromophenyl) ethyl group, 3- (4-iodophenyl) propyl group, 4- (2-bromophenyl) butyl group, 5- (3-chlorophenyl) pentyl group, 6- (4-bromophenyl) hexyl group, 1-dimethyl-2- (2, 4-dichlorophenyl) ethyl group, 2-methyl-3- (2, 4, 6-trifluorophenyl) propyl group, 2- (2-ethylphenyl) ethyl group, 1- (3-propylphenyl) ethyl group, 3- (4-butylphenyl) propyl group, 4- (2-pentylphenyl) butyl group, methyl-3- (2-iodophenyl) propyl group, methyl-5- (3-chlorophenyl) pentyl group, methyl-2-bromophenyl) hexyl group, methyl-3- (2, 5- (3-hexylphenyl) pentyl group, 6- (4-trifluoromethylphenyl) hexyl group, 1-dimethyl-2- (2, 4-dimethylphenyl) ethyl group, 2-methyl-3- [2, 4, 6-tris (trifluoromethyl) phenyl ] propyl group, 2- (2-ethoxyphenyl) ethyl group, 1- (3-propoxyphenyl) ethyl group, 3- (4-butoxyphenyl) propyl group, 4- (2-pentyloxyphenyl) butyl group, 5- (3-hexyloxyphenyl) pentyl group, 6- (4-trifluoromethoxyphenyl) hexyl group, 1-dimethyl-2- (2, 4-dimethoxyphenyl) ethyl group, 2-methyl-3- [2, 4, 6-tris (trifluoromethoxy) phenyl ] propyl, 2- (2-benzyloxyphenyl) ethyl, 1- [3- (2-phenylethoxy) phenyl ] ethyl, 3- [4- (3-phenylpropoxy) phenyl ] propyl, 4- [2- (4-phenylbutoxy) phenyl ] butyl, 5- [3- (5-phenylpentyloxy) phenyl ] pentyl, 6- [4- (6-phenylhexyloxy) phenyl ] hexyl, 1-dimethyl-2- (2, 4-diphenylmethoxyphenyl) ethyl, 2-methyl-3- (2, 4, 6-triphenylmethoxyphenyl) propyl, 2- (2-hydroxyphenyl) ethyl, 1- (3-hydroxyphenyl) ethyl, 2- (2-hydroxyphenyl) ethyl, 1- (2-phenylethoxy) ethyl, 2- (2-phenylethoxy) ethyl, 1- (3-phenyl) ethyl, 3- (4-hydroxyphenyl) propyl group, 4- (2-hydroxyphenyl) butyl group, 5- (3-hydroxyphenyl) pentyl group, 6- (4-hydroxyphenyl) hexyl group, 1-dimethyl-2- (2, 4-dihydroxyphenyl) ethyl group, 2-methyl-3- (2, 4, 6-trihydroxyphenyl) propyl group, 2- (3, 4-methylenedioxyphenyl) ethyl group, 1- (2, 3-ethylenedioxyphenyl) ethyl group, 3- (3, 4-trimethylenedioxyphenyl) propyl group, 4- (3, 4-tetramethylenedioxyphenyl) butyl group, 5- (3, 4-methylenedioxyphenyl) pentyl group, 6- (3, 4-ethylenedioxyphenyl) hexyl group, 2- (4-hydroxyphenyl) hexyl group, 2-methyl-3- (2, 4-trihydroxyphenyl) propyl group, 2- (3, 4-methylenedioxyphenyl) pentyl group, and, 1, 1-dimethyl-2- (3, 4-methylenedioxy) ethyl and 2-methyl-3- (3, 4-methylenedioxyphenyl) propyl. Preferably, it includes a lower alkyl group which may be substituted on the benzene ring by a phenyl group as a substituent selected from the group consisting of a lower alkanoyl group, an amino group which may have a lower alkanoyl group as a substituent, a lower alkoxycarbonyl group, a cyano group, a nitro group, a phenyl group, a halogen atom, a lower alkyl group which may have a halogen atom as a substituent, a lower alkoxy group which may have a halogen atom as a substituent, a phenyl lower alkoxy group, a hydroxyl group and a lower alkylenedioxy group.

The piperidyl lower alkyl group which may have 1 to 3 substituents selected from a hydroxyl group and a lower alkyl group which may have a hydroxyl group as a substituent on the pyridine ring includes, in addition to the above-mentioned piperidyl lower alkyl group, a piperidyl alkyl group which may have 1 to 3 substituents selected from a hydroxyl group and a linear or branched alkyl group having 1 to 6 carbon atoms which may have 1 to 3 hydroxyl groups as a substituent on the pyridine ring and the alkyl moiety thereof may be a linear or branched alkyl group having 1 to 6 carbon atoms, such as [ 2-methyl- (3, 4, 5 or 6-) pyridyl ] methyl, [ 2-methyl-3-hydroxy-5-hydroxymethyl- (4 or 6-) pyridyl ] methyl, 2- [ 3-ethyl- (2, 4, 5 or 6-) pyridyl ] ethyl, n-butyl, n-, 1- [ 4-propyl- (2, 3, 5 or 6-) pyridyl ] ethyl, 3- [ 2-butyl- (3, 4, 5 or 6-) pyridyl ] propyl, 4- [ 3-pentyl- (2, 4, 5 or 6-) pyridyl ] butyl, 1-dimethyl-2- [ 4-hexyl- (2, 3, 5 or 6-) pyridyl ] ethyl, 5- [2, 3-dimethyl- (4, 5 or 6-) pyridyl ] pentyl, 6- [2, 4, 6-trimethyl- (3 or 5-) pyridyl ] hexyl, 1- [ 2-hydroxy- (2, 3, 5 or 6-) pyridyl ] isopropyl, 2-methyl-3- [ 3-hydroxy- (2, 3, 5 or 6-) -pyridyl ] isopropyl, 4. 5 or 6-) pyridyl ] propyl, [ 2-hydroxy- (3, 4, 5 or 6-) pyridyl ] methyl, 2- [ 3-hydroxy- (2, 4, 5 or 6-) pyridyl ] ethyl, 1- [ 4-hydroxy- (2, 3, 5 or 6-) pyridyl ] ethyl, 3- [ 2-hydroxy- (3, 4, 5 or 6-) pyridyl ] propyl, 4- [ 3-hydroxy- (2, 4, 5 or 6-) pyridyl ] butyl, 1-dimethyl-2- [ 4-hydroxy- (2, 3, 5 or 6-) pyridyl ] ethyl, 5- [2, 3-dihydroxy- (4, 5 or 6-) pyridyl ] pentyl, 6- [2, 4, 6-trihydroxy- (3 or 5-) pyridyl ] hexyl, [ 2-hydroxymethyl- (3, 4, 5 or 6-) pyridyl ] methyl, 2- [3- (2-hydroxyethyl) - (2, 4, 5 or 6-) pyridyl } ethyl, 1- [4- (3-hydroxypropyl) - (2, 3, 5 or 6-) pyridyl ] ethyl, 3- [2- (4-hydroxybutyl) - (3, 4, 5 or 6-) pyridyl ] propyl, 4- [3- (5-hydroxypentyl) - (2, 4, 5 or 6-) pyridyl ] butyl, 1-dimethyl-2- [4- (6-hydroxyhexyl) - (2, 3, 5 or 6-) pyridyl ] ethyl, methyl, ethyl, propyl, butyl, pentyl, hexyl, pentyl, hexyl, 5- [2, 3-bis (hydroxymethyl) - (4, 5 or 6-) pyridyl ] pentyl, 6- [2, 4, 6-tris (hydroxymethyl) - (3 or 5-) pyridyl ] hexyl, 1- [ 2-hydroxymethyl- (2, 3, 5 or 6-) pyridyl ] isopropyl, 2-methyl-3- [3- (2, 3-dihydroxypropyl) - (2, 4, 5 or 6-) pyridyl ] propyl, [ 2-methyl-3- (2, 2, 4-trihydroxybutyl) - (4, 5 or 6-) pyridyl ] methyl and [ 2-methyl-5-hydroxymethyl- (3, 4 or 6-) pyridyl ] methyl.

Examples of the pyrrolyl lower alkyl group which may have 1 to 3 lower alkyl groups as substituents on the pyrrole ring include pyrrolyl alkyl groups which may have 1 to 3 straight-chain or branched alkyl groups having 1 to 6 carbon atoms on the pyrrole ring and the alkyl moiety thereof is a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as [ (1, 2 or 3-) pyrrolyl ] methyl, 2- [ (1, 2 or 3-) pyrrolyl ] ethyl, 1- [ (1, 2 or 3-) pyrrolyl ] ethyl, 3- [ (1, 2 or 3-) pyrrolyl ] propyl, 4- [ (1, 2 or 3-) pyrrolyl ] butyl, 5- [ (1, 2 or 3-) pyrrolyl ] pentyl, 6- [ (1, 2 or 3-) pyrrolyl ] hexyl, 1-dimethyl-2- [ (1, 1, 2 or 3-) pyrrolyl ] ethyl, 2-methyl-3- [ (1, 2 or 3-) pyrrolyl ] propyl, [ 1-methyl- (2 or 3-) pyrrolyl ] methyl, 2- [ 2-ethyl- (1, 3, 4 or 5-) pyrrolyl ] ethyl, 1- [ 3-propyl- (1, 2, 4 or 5-) pyrrolyl ] ethyl, 3- [ 1-butyl- (2, 3 or 4-) pyrrolyl ] propyl, 4- [ 2-pentyl- (1, 3, 4 or 5-) pyrrolyl ] butyl, 5- [ 3-hexyl- (1, 2, 4 or 5-) pyrrolyl ] pentyl, 6- [1, 2-dimethyl- (3, 4 or 5-) pyrrolyl ] hexyl, and hexyl, 1, 1-dimethyl-2- [1, 2, 3-trimethyl- (4 or 5-) pyrrolyl ] ethyl and 2-methyl-3- [ 1-ethyl-2-methyl- (3, 4 or 5-) pyrrolyl ] propyl.

Examples of the benzoxazolyl lower alkyl group include benzoxazolyl alkyl groups in which the alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as [ (2, 4, 5, 6 or 7-) benzoxazolyl ] methyl, 2- [ (2, 4, 5, 6 or 7-) benzoxazolyl ] ethyl, 1- [ (2, 4, 5, 6 or 7-) benzoxazolyl ] ethyl, 3- [ (2, 4, 5, 6 or 7-) benzoxazolyl ] propyl, 4- [ (2, 4, 5, 6 or 7-) benzoxazolyl ] butyl, 5- [ (2, 4, 5, 6 or 7-) benzoxazolyl ] pentyl, 6- [ (2, 4, 5, 6 or 7-) benzoxazolyl ] hexyl, 1-dimethyl-2- [ (2, 6 or 7-) benzoxazolyl ] hexyl, 1-dimethyl-2- [ (2, 4. 5, 6 or 7-) benzoxazolyl ethyl and 2-methyl-3- [ (2, 4, 5, 6 or 7-) benzoxazolyl ] propyl.

Examples of the benzothiazolyl lower alkyl group include a benzothiazolylalkyl group whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as [ (2, 4, 5, 6 or 7-) benzothiazolyl ] methyl, 2- [ (2, 4, 5, 6 or 7-) benzothiazolyl ] ethyl, 1- [ (2, 4, 5, 6 or 7-) benzothiazolyl ] ethyl, 3- [ (2, 4, 5, 6 or 7-) benzothiazolyl ] propyl, 4- [ (2, 4, 5, 6 or 7-) benzothiazolyl ] butyl, 5- [ (2, 4, 5, 6 or 7-) benzothiazolyl ] pentyl, 6- [ (2, 4, 5, 6 or 7-) benzothiazolyl ] hexyl, 1-dimethyl-2- [ (2, 7-), 4. 5, 6 or 7-) benzothiazolyl ] ethyl and 2-methyl-3- [ (2, 4, 5, 6 or 7-) benzothiazolyl ] propyl.

Examples of the furyl lower alkyl group include furyl alkyl groups whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as [ (2 or 3-) furyl ] methyl group, 2- [ (2 or 3-) furyl ] ethyl group, 1- [ (2 or 3-) furyl ] ethyl group, 3- [ (2 or 3-) furyl ] propyl group, 4- [ (2 or 3-) furyl ] butyl group, 5- [ (2 or 3-) furyl ] pentyl group, 6- [ (2 or 3-) furyl ] hexyl group, 1-dimethyl-2- [ (2 or 3-) furyl ] ethyl group and 2-methyl-3- [ (2 or 3-) furyl ] propyl group.

Examples of the thiazolidinyl lower alkyl group which may have an oxy group as a substituent on the thiazolidine ring include thiazolidinyl alkyl groups which may have 1 to 3 oxy groups as substituents on the thiazolidine ring and whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as (2, 3, 4 or 5-) thiazolidinyl methyl, 2- [ (2, 3, 4 or 5-) thiazolidinyl ] ethyl, 1- [ (2, 3, 4 or 5-) thiazolidinyl ] ethyl, 3- [ (2, 3, 4 or 5-) thiazolidinyl ] propyl, 4- [ (2, 3, 4 or 5-) thiazolidinyl ] butyl, 5- [ (2, 3, 4 or 5-) thiazolidinyl ] pentyl, 6- [ (2, 3, 4 or 5-) thiazolidinyl ] hexyl, 1-dimethyl-2- [ (2, 3. 4 or 5-) thiazolidinyl ] ethyl, 2-methyl-3- [ (2, 3, 4 or 5-) thiazolidinyl ] propyl, [2, 4-dioxo- (3 or 5-) thiazolidinyl ] methyl, 2- [ 2-oxo- (3, 4 or 5-) thiazolidinyl ] ethyl, 1- [ 4-oxo- (2, 3 or 5-) thiazolidinyl ] ethyl, 3- [ 2-oxo- (3, 4 or 5-) thiazolidinyl ] propyl, 4- [ 5-oxo- (2, 3 or 4-) thiazolidinyl ] butyl, 5- [2, 5-dioxo- (3 or 4-) thiazolidinyl ] pentyl, 6- [2, 4, 5-trioxo-3-thiazolidinyl ] hexyl, thiazolyl, and the like, 1- [4, 5-dioxo- (2 or 3-) thiazolidinyl ] ethyl, 2- [4, 5-dioxo- (2-or 3-) thiazolidinyl ] ethyl, 1-dimethyl-2- [2, 4-dioxo- (3 or 5-) thiazolidinyl ] ethyl and 2-methyl-3- [2, 4-dioxo- (3 or 5-) thiazolidinyl ] propyl.

Examples of the thiazolidinyl lower alkyl group which may have an oxy group as a substituent on the thiazolidine ring include thiazolidinyl alkyl groups which may have 1 to 3 oxy groups as substituents on the thiazolidine ring and whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as (2, 4, or 5-) thiazolidinylmethyl, (2, 4, or 5-) thiazolidinylethyl, (2, 4, or 5-) thiazolidinylpropyl, (2, 4, or 5-) thiazolidinylisopropyl, (2, 4, or 5-) thiazolidinylbutyl, (2, 4, or 5-) thiazolidinylpentyl, (2, 4, or 5-) thiazolidinylhexyl, 4, 5-dioxo-2-thiazolidinylmethyl, 2, 5-dioxo-4-thiazolidinylmethylmethylyl, 2, 4-dioxo-5-thiazolylidenemethyl, 4-oxo- (2 or 5-) thiazolylideneethyl, 5-oxo- (2 or 4-) thiazolylidenepropyl and 2-oxo- (4 or 5-) thiazolylidenebutyl.

Examples of the benzoyl group which may be substituted on the benzene ring by 1 to 3 groups selected from the group consisting of a cyano group, an amino group which may have a lower alkylsulfonyl group as a substituent, a halogen atom, a lower alkoxy group, a lower alkyl group which may have a halogen atom, a thiazolidinyl lower alkyl group which may have an oxy group as a substituent on the thiazolidine ring, a thiazolidinylidene lower alkyl group which may have an oxy group as a substituent on the thiazolidine ring and a lower alkylenedioxy group include an amino group which may be substituted on the benzene ring by a substituent selected from the group consisting of a cyano group, a linear or branched alkylsulfonyl group which may have 1 or 2 straight chain or branched alkylsulfonyl groups containing 1 to 6 carbon atoms, a halogen atom, a linear or branched alkoxy group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent, a thiazolidine ring which may have 1 to 3 oxy groups as a substituent on the thiazolidine ring and whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms An alkylthioalkyl group, a thiazolidinoalkyl group which may have 1 to 3 oxy groups as substituents on the thiazolidine ring and whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, and a benzoyl group substituted with 1 to 3 groups of a linear or branched alkylenedioxy group having 1 to 4 carbon atoms, such as benzoyl, 4-cyanobenzoyl, 3, 4-methylenedioxybenzoyl, 2-aminobenzoyl, 3-aminobenzoyl, 4-aminobenzoyl, 3, 4-diaminobenzoyl, 2, 4, 6-triaminobenzoyl, 4-methoxybenzoyl, 4-trifluoromethylbenzoyl, 4-chlorobenzoyl, 3, 4-difluorobenzoyl, 2-fluorobenzoyl, 3-bromobenzoyl, 4-iodobenzoyl, 3, 4-dimethoxybenzoyl, 4-fluorobenzoyl, 3-cyanobenzoyl, 2, 3-dicyanobenzoyl, 3, 4, 5-tricyanobenzoyl, 4-methylbenzoyl, 4- (2, 4-dioxothiazolidinylmethyl) benzoyl, 2-methylbenzoyl, 3-methylbenzoyl, 2-ethylbenzoyl, 3-ethylbenzoyl, 4-isopropylbenzoyl, 3-butylbenzoyl, 4-pentylbenzoyl, 4-hexylbenzoyl, 3, 4-dimethylbenzoyl, 2-dioxothiazolidinylmethyl, 4-thiazolylmethyl, 4-ethylbenzoyl, 4-isopropylbenzoyl, 3-butylbenzoyl, 4-pentylbenzoyl, 4-hexylbenzoyl, 3, 4-dimethylbenzoyl, 2-dioxothiazolid, 3, 4-diethylbenzoyl, 2, 4-dimethylbenzoyl, 2, 5-dimethylbenzoyl, 2, 6-dimethylbenzoyl, 3, 4, 5-trimethylbenzoyl, 2-methoxybenzoyl, 3-methoxybenzoyl, 2-ethoxybenzoyl, 3-ethoxybenzoyl, 4-isopropoxybenzoyl, 3-butoxybenzoyl, 4-pentyloxybenzoyl, 4-hexyloxybenzoyl, 3, 4-diethoxybenzoyl, 2, 4-dimethoxybenzoyl, 2, 5-dimethoxybenzoyl, 2, 6-dimethoxybenzoyl, 3, 4, 5-trimethoxybenzoyl, 2, 6-dimethoxybenzoyl, 2, 4-dimethylbenzoyl, 2, 5-dimethylbenzoyl, 2, 6-dimethylbenzoyl, 3, 4, 5-dimethylbenzoyl, 2, 6-methoxybenzoyl, 2-ethoxybenzoyl, 4-methoxybenzoyl, 2-trifluoromethylbenzoyl, 3-trifluoromethylbenzoyl, 4-trifluoromethylbenzoyl, 2- (bromomethyl) benzoyl, 3- (2-chloroethyl) benzoyl, 4- (2, 3-dichloropropyl) benzoyl, 4- (4-fluorobutyl) benzoyl, 3- (5-chloropentyl) benzoyl, 4- (5-bromohexyl) benzoyl, 4- (5, 6-dibromohexyl) benzoyl, 3, 4-bis (trifluoromethyl) benzoyl, 3, 4-bis (4, 4, 4-trichlorobutyl) benzoyl, 2, 4-bis (3-chloro-2-methylpropyl) benzoyl, 2, 5-bis (3-chloropropyl) benzoyl, 2- (bromomethyl) benzoyl, 4- (2, 3-dichloropropyl) benzoyl, 4-trifluoromethylbenzoyl, 4-fluorobutyl) benzoyl, 3- (5-chloropentyl) benzoyl, 4-chlorobutyl) benzoyl, 2, 4-bis (3-bromohexyl) benzoyl, 4, 2, 6-bis (2, 2, 2-trifluoroethyl) benzoyl, 3, 4, 5-tris (trifluoromethyl) benzoyl, 4- (2, 2, 2-trichloroethyl) benzoyl, 2-methyl-4-trifluoromethylbenzoyl, 3-ethyl-4-trichloromethylbenzoyl, 2-methoxy-4-trifluoromethylbenzoyl, 3-ethyl-4-fluorobenzoyl, 3-ethoxy-4-trichloromethylbenzoyl, 2-methyl-3-trifluoromethyl-4-trifluoromethylbenzoyl, 3-fluorobenzoyl, 4-fluorobenzoyl, 2-bromobenzoyl, 4-bromobenzoyl, 2-iodobenzoyl, and, 3-iodobenzoyl, 2, 3-dibromobenzoyl, 2, 4-diiodobenzoyl, 2, 5-difluorobenzoyl, 2, 6-dichlorobenzoyl, 2, 4, 6-trichlorobenzoyl, 2, 4-difluorobenzoyl, 3, 5-difluorobenzoyl, 2, 6-difluorobenzoyl, 2-chlorobenzoyl, 3-chlorobenzoyl, 4-chlorobenzoyl, 2, 3-dichlorobenzoyl, 2, 4-dichlorobenzoyl, 2, 5-dichlorobenzoyl, 3, 4-dichlorobenzoyl, 2, 6-dichlorobenzoyl, 3, 5-dichlorobenzoyl, 2, 4, 6-trifluorobenzoyl, 2, 4-difluorobenzoyl, 3, 5-dichlorobenzoyl, 2, 6-trifluorobenzoyl, 2, 4-difluorobenzoyl, 2, 5-difluorobenzoyl, 2, 6-difluorobenzoyl, 3, 4-difluorobenzoyl, 3, 4-methylenedioxybenzoyl, 3, 4-trimethylenedioxybenzoyl, 2, 3-ethylenedioxybenzoyl, 3, 4-trimethylenedioxybenzoyl, 2, 3-tetramethylenedioxybenzoyl, 2, 3-methylenedioxybenzoyl, 3, 4-ethylenedioxybenzoyl and 2-methylsulfonylaminobenzoyl.

Can be substituted on the thiazolidine ring with a group selected from oxo and oxo:

[ general formula 56]

(wherein R is^aAnd R^bEach represents a lower alkyl group) include thiazolidinyl lower alkanoyl groups which may be substituted on the thiazolidine ring with a substituent selected from the group consisting of oxo and a group:

[ general formula 57]

(wherein R is^aAnd R^bEach represents a linear or branched alkyl group having 1 to 6 carbon atoms) and the alkanoyl moiety thereof is a linear or branched alkanoyl group having 2 to 6 carbon atoms, for example, 2- [ (2, 3, 4 or 5-) thiazolidinyl]Acetyl, 3- [ (2, 3, 4 or 5-) thiazolidinyl]Propionyl, 2- [ (2, 3, 4 or 5-) thiazolidinyl]Propionyl, 4- [ (2, 3, 4 or 5-) thiazolidinyl]Butyryl, 5- [ (2, 3, 4 or 5-) thiazolidinyl]Pentanoyl, 6- [ (2, 3, 4 or 5-) thiazolidinyl]Hexanoyl, 2-dimethyl-3- [ (2, 3, 4 or 5-) thiazolidinyl]Propionyl, 2-methyl-3- [ (2, 3, 4 or 5-) thiazolidinyl]Propionyl group, [2, 4-dioxo- (3 or 5-) thiazolidinyl group]Acetyl, 3- [ 2-oxo- (3, 4 or 5-) thiazolidinyl]Propionyl, 2- [ 4-oxo- (2, 3 or 5-) thiazolidinyl]Propionyl, 4- [ 5-oxo- (2, 3 or 4-) thiazolidinyl]Butyryl, 5- [2, 5-dioxo- (3 or 4-) thiazolidinyl ]Pentanoyl, 6- [2, 4, 5-trioxo-3-thiazolidinyl]Hexanoyl, 2- [4, 5-dioxo- (2 or 3-) thiazolidinyl]Acetyl, 2-dimethyl-3- [2, 4-dioxo- (3 or 5-) thiazolidinyl]Propionyl, 2-methyl-3- [2, 4-dioxo- (3 or 5-) thiazolidinyl]Propionyl, 2- [ 4-oxo-2-isoPropyleneimido- (3 or 5-) thiazolidinyl]Acetyl, 2- [ 2-oxo-5-isopropylidenediamino- (3 or 4-) thiazolidinyl]Acetyl, 2- [2, 4-bis (isopropylideneamino) - (3 or 5-) thiazolidinyl]Acetyl, 3- [ 2-methylenedianilino- (3, 4 or 5-) thiazolidinyl]Propionyl, 2- [ 4-ethylideneimino- (2, 3 or 5-) thiazolidinyl]Propionyl, 4- [ 5-propyleneimido- (2, 3 or 4-) thiazolidinyl]Butyryl, 5- [2, 5-bis (isopropylideneamino) - (3 or 4-) thiazolidinyl]Pentanoyl, 6- [2, 4, 5-tris (isopropylidenediamino) -3-thiazolidinyl]Hexanoyl, 2- [4, 5-bis (isopropylidenediamino) - (2 or 3-) thiazolidinyl]Acetyl, 2-dimethyl-3- [ 4-butylideneamino- (2, 3 or 5-) thiazolidinyl]Propionyl, 2-methyl-3- [ 5-pentylene- (2, 3 or 4-) thiazolidinyl]Propionyl and 2- (hexylidene) amino) - (3, 4 or 5-) thiazolidinyl acetyl.

Examples of the lower alkyl group which may have a substituent selected from the group consisting of a hydroxyl group and a halogen atom include, in addition to the above-mentioned lower alkyl groups, straight-chain or branched-chain alkyl groups having 1 to 6 carbon atoms which may have 1 to 3 substituents selected from the group consisting of a hydroxyl group and a halogen atom, for example, hydroxymethyl, 2-hydroxyethyl, 1-hydroxyethyl, 3-hydroxypropyl, 2, 3-dihydroxypropyl, 4-hydroxybutyl, 1-dimethyl-2-hydroxyethyl, 5, 4-trihydroxypentyl, 5-hydroxypentyl, 6-hydroxyhexyl, 1-hydroxyisopropyl, 2-methyl-3-hydroxypropyl, trifluoromethyl, trichloromethyl, chloromethyl, bromomethyl, fluoromethyl, iodomethyl, difluoromethyl, dibromomethyl, 2-chloroethyl, 2, 2, 2-trifluoroethyl, and, 2, 2, 2-trichloroethyl, 3-chloropropyl, 2, 3-dichloropropyl, 4, 4, 4-trichlorobutyl, 4-fluorobutyl, 5-chloropentyl, 3-chloro-2-methylpropyl, 5-bromohexyl, 5, 6-dibromohexyl, 2-hydroxy-3-fluoropropyl and 2, 2-dichloro-3-hydroxybutyl.

Examples of the carbamoyl group which may have a group selected from the group consisting of a lower alkoxy lower alkyl group and a lower alkyl group include carbamoyl groups which may have 1 or 2 groups selected from the group consisting of a linear or branched alkyl group having 1 to 6 carbon atoms and a linear or branched alkyl group having 1 to 6 carbon atoms which is selected from the group consisting of a linear or branched alkoxy group having 1 to 6 carbon atoms, such as carbamoyl group, N- (2-methoxyethyl) carbamoyl group, methylcarbamoyl group, ethylcarbamoyl group, propylcarbamoyl group, isopropylcarbamoyl group, butylcarbamoyl group, t-butylcarbamoyl group, pentylcarbamoyl group, hexylcarbamoyl group, dimethylcarbamoyl group, diethylcarbamoyl group, dipropylcarbamoyl group, dibutylcarbamoyl group, dipentylcarbamoyl group, dihexylcarbamoyl group, di-propylcarbamoyl group, N-ethylcarbamoyl group, N- (2-methoxyethyl) carbamoyl group, N-methyl-N-ethylcarbamoyl group, N-ethyl-N-propylcarbamoyl group, N-methyl-N-butylcarbamoyl group, N-methyl-N-hexylcarbamoyl group, N- (methoxymethyl) carbamoyl group, N- (3-propoxypropyl) carbamoyl group, N- (4-butoxybutyl) carbamoyl group, N- (4-ethoxybutyl) carbamoyl group, N- (5-pentyloxypentyl) carbamoyl group, N- (5-methoxypentyl) carbamoyl group, N- (6-hexyloxyhexyl) carbamoyl group, bis (2-methoxyethyl) carbamoyl group, N- (2-methoxyethyl) -N-methylcarbamoyl group and N- (2-methoxyethyl) -N-methylcarbamoyl group ) -N-ethylcarbamoyl.

Examples of the phenyl group which may be substituted on the benzene ring with 1 to 3 groups selected from the group consisting of a carbamoyl group which may have a group selected from the group consisting of a lower alkoxy lower alkyl group and a lower alkyl group, a lower alkoxycarbonyl group, a carboxyl group, a cyano group, a phenyl group, a halogen atom, a lower alkyl group which may have a halogen atom as a substituent, a lower alkoxy group which may have a halogen atom as a substituent, a benzoyl group which may have a halogen atom as a substituent on the benzene ring, a phenyl lower alkyl group which may have a halogen atom as a substituent on the benzene ring, and a hydroxyl group include a carbamoyl group which may be substituted on the benzene ring with 1 to 2 groups selected from the group consisting of a straight-chain or branched alkoxy group which may have an alkoxy group selected from the group consisting of a straight-chain or branched alkyl group whose alkoxy group is a straight-chain or branched alkyl group having 1 to 6 carbon atoms and a straight-chain or branched alkyl group, An alkoxycarbonyl group whose alkoxy group is a straight-chain or branched-chain alkoxy group having 1 to 6 carbon atoms, a carboxyl group, a cyano group, a phenyl group, a halogen atom, a straight-chain or branched-chain alkyl group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent, a straight-chain or branched-chain alkoxy group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent, a benzoyl group which may have 1 to 3 halogen atoms as a substituent on a benzene ring, a phenylalkyl group which may have 1 to 3 halogen atoms as a substituent on a benzene ring and whose alkyl moiety is a straight-chain or branched-chain alkyl group having 1 to 6 carbon atoms, and a phenyl group substituted with 1 to 3 groups of a hydroxyl group, such as a phenyl group, a 2-methylphenyl group, a 3-methylphenyl group, a 4-methylphenyl group, a 2-ethylphenyl group, a 3-ethylphenyl group, 4-ethylphenyl group, 4-isopropylphenyl group, 3-butylphenyl group, 4-pentylphenyl group, 4-hexylphenyl group, 3, 4-dimethylphenyl group, 3, 4-diethylphenyl group, 2, 4-dimethylphenyl group, 2, 3-dimethylphenyl group, 2, 5-dimethylphenyl group, 2, 6-dimethylphenyl group, 3, 4, 5-trimethylphenyl group, 2-methoxyphenyl group, 3-methoxyphenyl group, 4-methoxyphenyl group, 2-ethoxyphenyl group, 3-ethoxyphenyl group, 4-isopropoxyphenyl group, 3-butoxyphenyl group, 4-pentyloxyphenyl group, 4-hexyloxyphenyl group, 3, 4-dimethoxyphenyl group, 3, 4-diethoxyphenyl group, 2-propylphenyl group, 2, 4-dimethylphenyl group, 2, 5-dimethylphenyl group, 2, 6-dimethylphenyl group, 3, 4, 2, 4-dimethoxyphenyl group, 2, 5-dimethoxyphenyl group, 2, 6-dimethoxyphenyl group, 3, 4, 5-trimethoxyphenyl group, 2-trifluoromethoxyphenyl group, 3-trifluoromethoxyphenyl group, 4-trifluoromethoxyphenyl group, 2- (bromomethoxy) phenyl group, 3- (2-chloroethoxy) phenyl group, 4- (2, 3-dichloropropoxy) phenyl group, 4- (4-fluorobutoxy) phenyl group, 3- (5-chloropentyloxy) phenyl group, 4- (5-bromohexyloxy) phenyl group, 4- (5, 6-dibromohexyloxy) phenyl group, 3, 4-bis (trifluoromethoxy) phenyl group, 3, 4-bis (4, 4, 4-trichlorobutoxy) phenyl group, 2, 4-bis (3-chloro-2-methoxypropyl) phenyl group, 2, 5-bis (3-chloropropyloxy) phenyl, 2, 6-bis (2, 2, 2-trifluoroethoxy) phenyl, 3, 4, 5-tris (trifluoromethoxy) phenyl, 4- (2, 2, 2-trichloroethoxy) phenyl, 2-methyl-4-trifluoromethoxyphenyl, 3-ethyl-4-trichloromethoxyphenyl, 2-methoxy-4-trifluoromethoxyphenyl, 3-ethoxy-4-trichloromethoxyphenyl, 2-trifluoromethylphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 2- (bromomethyl) phenyl, 3- (2-chloroethyl) phenyl, 4- (2, 3-dichloropropyl) phenyl, 4- (4-fluorobutyl) phenyl, 2-bis (2, 2, 2-trifluoroethoxy) phenyl, 3-bis (2-chloroethyl) phenyl, 4- (2, 3-dichloropropyl) phenyl, 4- (4-fluorobutyl) phenyl, 2, 6-bis (2, 2, 3- (5-chloropentyl) phenyl, 4- (5-bromohexyl) phenyl, 4- (5, 6-dibromohexyl) phenyl, 3, 4-bis (trifluoromethyl) phenyl, 3, 4-bis (4, 4, 4-trichlorobutyl) phenyl, 2, 4-bis (3-chloro-2-methylpropyl) phenyl, 2, 5-bis (3-chloropropyl) phenyl, 2, 6-bis (2, 2, 2-trifluoroethyl) phenyl, 3, 4, 5-tris (trifluoromethyl) phenyl, 4- (2, 2, 2-trichloroethyl) phenyl, 2-methyl-4-trifluoromethylphenyl, 3-ethyl-4-trichloromethylphenyl, 2-methoxycarbonylphenyl, 3-dibromohexyl, 4-methoxycarbonylphenyl, 2-ethoxycarbonylphenyl, 3-ethoxycarbonylphenyl, 4-isopropyloxycarbonylphenyl, 3-butoxycarbonylphenyl, 4-tert-butoxycarbonylphenyl, 4-pentyloxycarbonylphenyl, 4-hexyloxycarbonylphenyl, 3, 4-dimethoxycarbonylphenyl, 3, 4-diethoxycarbonylphenyl, 2, 4-dimethoxycarbonylphenyl, 2, 5-diethoxycarbonylphenyl, 2, 6-dimethoxycarbonylphenyl, 3, 4, 5-triethoxycarbonylphenyl, 2-cyanophenyl, 3-cyanophenyl, 4-cyanophenyl, 3, 4-dicyanophenyl, 3, 5-dicyanophenyl, 2, 4-dicyanophenyl, 2, 5-dicyanophenyl, 2, 6-dicyanophenyl group, 3, 4, 5-tricyanophenyl group, 2-phenylphenyl group, 3-phenylphenyl group, 4-phenylphenyl group, 3, 4-diphenylphenyl group, 3, 5-diphenylphenyl group, 2, 4-diphenylphenyl group, 2, 5-diphenylphenyl group, 2, 6-diphenylphenyl group, 3, 4, 5-triphenylphenyl group, 2-chlorophenyl group, 3-chlorophenyl group, 4-chlorophenyl group, 2, 3-dichlorophenyl group, 2, 4-dichlorophenyl group, 2, 5-dichlorophenyl group, 3, 4-dichlorophenyl group, 2, 6-dichlorophenyl group, 3, 5-dichlorophenyl group, 2, 4, 6-trichlorophenyl group, 2-fluorophenyl group, 3-fluorophenyl group, 4-fluorophenyl group, 2, 5-difluorophenyl group, 2, 4-difluorophenyl group, 3, 5-difluorophenyl group, 2, 6-difluorophenyl group, 2, 4, 6-trifluorophenyl group, 2-bromophenyl group, 3-bromophenyl group, 4-bromophenyl group, 2-iodophenyl group, 3-iodophenyl group, 4-iodophenyl group, 2, 3-dibromophenyl group, 2, 4-diiodophenyl group, 2-hydroxyphenyl group, 3-hydroxyphenyl group, 4-hydroxyphenyl group, 3, 4-dihydroxyphenyl group, 3, 5-dihydroxyphenyl group, 2, 4-dihydroxyphenyl group, 2, 5-dihydroxyphenyl group, 2, 6-dihydroxyphenyl group, 3, 4, 5-trihydroxyphenyl group, 3-benzylphenyl group, 2- (2-phenylethyl) phenyl group, 4- (1-phenylethyl) phenyl group, 3-phenylethyl group, 2- (3-phenylpropyl) phenyl, 3- (4-phenylbutyl) phenyl, 4- (5-phenylpentyl) phenyl, 2- (6-phenylhexyl) phenyl, 4- (1, 1-dimethyl-2-phenylethyl) phenyl, 3- (2-methyl-3-phenylpropyl) phenyl, 2- (4-fluorophenylmethyl) phenyl, 2-methyl-5-chlorophenyl, 2-methoxy-5-chlorophenyl, 4- (4-fluorophenylformyl) phenyl, 4- (4-fluorophenylmethyl) phenyl, 3- (2-chlorophenylmethyl) phenyl, 4- (3-chlorophenylmethyl) phenyl, 2- (4-chlorophenylmethyl) phenyl, 3- [2- (4-fluorophenyl) ethyl ] phenyl, methyl, ethyl, propyl, butyl, pentyl, hexyl, and hexyl, 4- [2- (4-chlorophenyl) ethyl ] phenyl, 2- (3, 4-dibromophenylmethyl) phenyl, 3- (3, 4-diiodophenylmethyl) phenyl, 4- (2, 4-difluorophenylmethyl) phenyl, 2- (2, 5-dichlorophenylmethyl) phenyl, 3- (2, 6-dichlorophenylmethyl) phenyl, 4- (3, 4, 5-trifluorophenylmethyl) phenyl, 2- [3- (4-chlorophenyl) propyl ] phenyl, 3- [1- (2-bromophenyl) ethyl ] phenyl, 4- [4- (3-fluorophenyl) butyl ] phenyl, 2- [5- (4-iodophenyl) pentyl ] phenyl, 3- [6- (4-chlorophenyl) hexyl ] phenyl, 2- [1, 1-dimethyl-2- (3-fluorophenyl) ethyl ] phenyl, 4- [ 2-methyl-3- (4-chlorophenyl) propyl ] phenyl, 2, 4-benzhydrylphenyl, 2, 4, 6-tritylphenyl, 2-chloro-4-cyanophenyl, 3-hydroxy-4-phenylphenyl, 3-ethoxycarbonyl-2-benzoylphenyl, 2-benzyl-4-methyl-6-methoxyphenyl, 4- [ (2-methoxyethyl) carbamoyl ] phenyl, 3- (N-ethyl-N-isopropylcarbamoyl) phenyl, 4-dimethylcarbamoylphenyl, 2-carboxyphenyl, N-propylcarbamoyl, phenyl, N-propylcarbamoyl, 3-carboxyphenyl and 4-carboxyphenyl.

Examples of the phenyl group having a lower alkylenedioxy group as a substituent on the benzene ring include phenyl groups having a linear or branched alkylenedioxy group containing 1 to 4 carbon atoms as a substituent on the benzene ring, such as 3, 4-methylenedioxyphenyl group, 3, 4-trimethylenedioxyphenyl group, 2, 3-ethylenedioxyphenyl group, 2, 3-tetramethylenedioxyphenyl group, 2, 3-methylenedioxyphenyl group, 3, 4-ethylenedioxyphenyl group and 2, 3-trimethylenedioxyphenyl group.

Examples of the naphthyl lower alkyl group include naphthylalkyl groups whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as (1 or 2-) naphthylmethyl, 2- [ (1 or 2-) naphthyl ] ethyl, 1- [ (1 or 2-) naphthyl ] ethyl, 3- [ (1 or 2-) naphthyl ] propyl, 4- [ (1 or 2-) naphthyl ] butyl, 5- [ (1 or 2-) naphthyl ] pentyl, 6- [ (1 or 2-) naphthyl ] hexyl, 1-dimethyl-2- [ (1 or 2-) naphthyl ] ethyl and 2-methyl-3- [ (1 or 2-) naphthyl ] propyl.

Examples of the phenoxy group which may be substituted on the benzene ring with 1 to 3 groups selected from the group consisting of a cyano group, a lower alkyl group which may have a halogen atom as a substituent, and a lower alkoxy group which may have a halogen atom as a substituent include phenoxy groups which may be substituted on the benzene ring with 1 to 3 groups selected from the group consisting of a cyano group, a straight-chain or branched alkyl group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent, and a straight-chain or branched alkoxy group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent, such as phenoxy group, 2-methylphenoxy group, 3-methylphenyl group, 4-methylphenoxy group, 2-ethylphenoxy group, 3-ethylphenoxy group, 4-isopropylphenoxy group, 3-butylphenoxy group, 4-pentylphenoxy group, 4-hexylphenoxy group, 3, 4-dimethylphenoxy group, 3, 4-diethylphenoxy group, 2, 4-dimethylphenoxy group, 2, 5-dimethylphenoxy group, 2, 6-dimethylphenoxy group, 3, 4, 5-trimethylphenoxy group, 2-methoxyphenoxy group, 3-methoxyphenoxy group, 4-methoxyphenoxy group, 2-ethoxyphenoxy group, 3-ethoxyphenoxy group, 4-isopropoxyphenoxy group, 3-butoxyphenoxy group, 4-pentyloxyphenoxy group, 4-hexylphenoxy group, 3, 4-dimethoxyphenoxy group, 3, 4-diethoxyphenoxy group, 2, 4-dimethoxyphenoxy group, 2, 5-dimethoxyphenoxy group, 2-dimethoxyphenoxy group, 3, 4-diethylphenoxy group, 2-n-ethoxyphenoxy group, 2-ethoxyphenoxy group, 2, 6-dimethoxyphenoxy group, 3, 4, 5-trimethoxyphenoxy group, 2-trifluoromethoxyphenoxy group, 3-trifluoromethoxyphenoxy group, 4-trifluoromethoxyphenoxy group, 2- (bromomethoxy) phenoxy group, 3- (2-chloroethoxy) phenoxy group, 4- (2, 3-dichloropropoxy) phenoxy group, 4- (4-fluorobutoxy) phenoxy group, 3- (5-chloropentyloxy) phenoxy group, 4- (5-bromohexyloxy) phenoxy group, 4- (5, 6-dibromohexyloxy) phenoxy group, 3, 4-bis (trifluoromethoxy) phenoxy group, 3, 4-bis (4, 4, 4-trichlorobutoxy) phenoxy group, 2, 4-bis (3-chloro-2-methoxypropyl) phenoxy group, 2-trichloro-ethoxy group, 2-methoxy-propoxy group, 2-fluorophenoxy group, 2-fluoropheno, 2, 5-bis (3-chloropropyloxy) phenoxy group, 2, 6-bis (2, 2, 2-trifluoroethoxy) phenoxy group, 3, 4, 5-tris (trifluoromethoxy) phenoxy group, 4- (2, 2, 2-trichloroethoxy) phenoxy group, 2-methyl-4-trifluoromethoxyphenoxy group, 3-ethyl-4-trichloromethoxyphenoxy group, 2-methoxy-4-trifluoromethoxyphenoxy group, 3-ethoxy-4-trichloromethoxyphenoxy group, 2-trifluoromethylphenoxy group, 3-trifluoromethylphenoxy group, 4-trifluoromethylphenoxy group, 2- (bromomethyl) phenoxy group, 3- (2-chloroethyl) phenoxy group, 4- (2, 3-dichloropropyl) phenoxy group, 2-bromomethyl) phenoxy group, 2-chloroethyl) phenoxy group, 2-trichlorophenoxy, 4- (4-fluorobutyl) phenoxy group, 3- (5-chloropentyl) phenoxy group, 4- (5-bromohexyl) phenoxy group, 4- (5, 6-dibromohexyl) phenoxy group, 3, 4-bis (trifluoromethyl) phenoxy group, 3, 4-bis (4, 4, 4-trichlorobutyl) phenoxy group, 2, 4-bis (3-chloro-2-methylpropyl) phenoxy group, 2, 5-bis (3-chloropropyl) phenoxy group, 2, 6-bis (2, 2, 2-trifluoroethyl) phenoxy group, 3, 4, 5-tris (trifluoromethyl) phenoxy group, 4- (2, 2, 2-trichloroethyl) phenoxy group, 2-methyl-4-trifluoromethylphenoxy group, 3-ethyl-4-trichloromethylphenoxy group, 3-bromohexylphenoxy group, 4- (5-bromohexyl) phenoxy group, 4- (5, 6-bis (trifluoromethyl) phenoxy group, 2, 2-trichloro-ethyl) phenoxy, 2-cyanophenoxy group, 3-cyanophenoxy group, 4-cyanophenoxy group, 3, 4-dicyanophenoxy group, 3, 5-dicyanophenoxy group, 2, 3-dicyanophenoxy group, 2, 4-dicyanophenoxy group, 2, 5-dicyanophenoxy group, 2, 6-dicyanophenoxy group, 3, 4, 5-tricyanophenoxy group, 2-cyano-4-methylphenoxy group, 3-cyano-4-methoxyphenoxy group, 3-cyano-5-trifluoromethylphenoxy group and 4-cyano-3-trifluoromethoxy phenoxy group.

Examples of the phenyl lower alkoxy group which may be substituted on the benzene ring with 1 to 3 groups selected from a halogen atom, a lower alkyl group which may have a halogen atom as a substituent and a lower alkoxy group which may have a halogen atom as a substituent include, in addition to the above-mentioned phenyl lower alkoxy group, a phenylalkoxy group which may be substituted on the benzene ring with 1 to 3 groups selected from a halogen atom, a straight-chain or branched alkyl group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent and a straight-chain or branched alkoxy group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent and whose alkoxy group moiety is a straight-chain or branched alkoxy group having 1 to 6 carbon atoms, such as 2, 5-difluorobenzyloxy, 2, 4-difluorobenzyloxy, 3, 5-difluorobenzyloxy, 2, 6-difluorobenzyloxy, 3-trifluoromethylbenzyloxy, 2-trifluoromethylbenzyloxy, 4-trifluoromethylbenzyloxy, 3, 4-dimethoxybenzyloxy, 3, 5-dimethoxybenzyloxy, 2-chlorophenoxy, 3-chlorophenoxy, 4-chlorophenoxy, 2-methylphenoxy, 3-methylphenoxy, 4-methylphenoxy, 3, 4-dimethylphenoxy, 2, 3-dimethylphenylmethoxy, 2-methoxyphenylmethoxy, 3-methoxyphenylmethoxy, 4-methoxyphenylmethoxy, 2, 3-dichlorophenoxy, 2, 4-dichlorophenoxymethoxy, 2, 5-dichlorophenoxy, 2-dichlorophenoxy, 3-dichlorophenoxy, 2, 4-dichlorophenoxy, 2, 5-dichlorophenoxy, 2-dichlorophenoxy, 3-dichlorophenoxy, 4-dichlorophenoxy, 2, 5-dichlorophenoxy, 2, 3, 4-dichlorophenylmethoxy, 2, 6-dichlorophenylmethoxy, 4-fluorophenylmethoxy, 3-fluorophenylmethoxy, 2-fluorophenylmethoxy, 3-trifluoromethoxyphenylmethoxy, 4-trifluoromethoxyphenylmethoxy, 2-trifluoromethoxyphenylmethoxy, 4-tert-butylbenzylmethoxy, 4-ethylbenzyloxy, 4-isopropylphenylmethoxy, 4-methoxy-3-chlorophenylmethoxy, 2- (4-methoxyphenyl) ethoxy, 2- (4-fluorophenyl) ethoxy, 2- (4-chlorophenyl) ethoxy, 2- (3-methoxyphenyl) ethoxy, 2- (4-methylphenyl) ethoxy, 3-methyl-4-chlorophenylmethoxy, m, 4- (4-methoxyphenyl) butoxy, 2- (4-methylphenyl) ethoxy, 4-tert-butoxyphenylmethoxy, 3-chloro-6-methoxyphenylmethoxy, 4-methoxy-3-methylphenylmethoxy, 2- (2-fluorophenyl) ethoxy, 1- (3-bromophenyl) ethoxy, 3- (4-iodophenyl) propoxy, 4- (2-bromophenyl) butoxy, 5- (3-chlorophenyl) pentyloxy, 6- (4-bromophenyl) hexyloxy, 1-dimethyl-2- (2, 4-dichlorophenyl) ethoxy, 2-methyl-3- (2, 4, 6-trifluorophenyl) propoxy, 2- (2-ethylphenyl) ethoxy, ethoxy, 1- (3-propylphenyl) ethoxy group, 3- (4-butylphenyl) propoxy group, 4- (2-pentylphenyl) butoxy group, 5- (3-hexylphenyl) pentyloxy group, 6- (4-trifluoromethylphenyl) hexyloxy group, 1-dimethyl-2- (2, 4-dimethylphenyl) ethoxy group, 2-methyl-3- [2, 4, 6-tris (trifluoromethyl) phenyl ] propoxy group, 2- (2-ethoxyphenyl) ethoxy group, 1- (3-propoxyphenyl) ethoxy group, 3- (4-butoxyphenyl) propoxy group, 4- (2-pentyloxyphenyl) butoxy group, 5- (3-hexyloxyphenyl) pentyloxy group, 6- (4-trifluoromethoxyphenyl) hexyloxy group, n, 1, 1-dimethyl-2- (2, 4-dimethoxyphenyl) ethoxy and 2-methyl-3- [2, 4, 6-tris (trifluoromethoxy) phenyl ] propoxy.

Examples of the lower alkyl group substituted with 1, 2, 3, 4-tetrahydronaphthyl group which may have 1 to 5 lower alkyl groups as substituents on the 1, 2, 3, 4-tetrahydronaphthyl ring include alkyl groups substituted with 1, 2, 3, 4-tetrahydronaphthyl group which may have 1 to 5 straight-chain or branched alkyl groups containing 1 to 6 carbon atoms as substituents on the 1, 2, 3, 4-tetrahydronaphthyl ring and whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as (1, 2, 5 or 6-)1, 2, 3, 4-tetrahydronaphthyl methyl, 2- [ (1, 2, 5 or 6-)1, 2, 3, 4-tetrahydronaphthyl ] ethyl, 1- [ (1, 2, 5 or 6-)1, 2, 3, 4-tetrahydronaphthyl ] ethyl, 3- [ (1, 2, 5 or 6-)1, 3, 4-tetrahydronaphthyl ] ethyl, 3- [ (1, 2, 5 or 6-)1, 2. 5 or 6-)1, 2, 3, 4-tetrahydronaphthyl ] propyl, 4- [ (1, 2, 5 or 6-)1, 2, 3, 4-tetrahydronaphthyl ] butyl, 5- [ (1, 2, 5 or 6-)1, 2, 3, 4-tetrahydronaphthyl ] pentyl, 6- [ (1, 2, 5 or 6-)1, 2, 3, 4-tetrahydronaphthyl ] hexyl, 1-dimethyl-2- [ (1, 2, 5 or 6-)1, 2, 3, 4-tetrahydronaphthyl ] ethyl, 2-methyl-3- [ (1, 2, 5 or 6-)1, 2, 3, 4-tetrahydronaphthyl ] propyl, 1, 4, 4-tetramethyl (2, 3, 5 or 6-)1, 2, 3, 4-tetrahydronaphthyl methyl, methyl, 1, 1, 4, 4, 5-pentamethyl (2, 3, 6, 7 or 8-)1, 2, 3, 4-tetrahydronaphthylmethyl, 1, 4, 4-trimethyl (2, 3, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydronaphthylmethyl, 5, 6-dimethyl (2, 3, 7 or 8-)1, 2, 3, 4-tetrahydronaphthylmethyl, 2- [ 1-methyl- (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydronaphthyl ] ethyl, 1- [ 2-ethyl- (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydronaphthyl ] ethyl, 3- [ 3-propyl- (1, 2, 3, 4, 5, 4-tetrahydronaphthyl) ethyl, 6. 7 or 8-)1, 2, 3, 4-tetrahydronaphthyl ] propyl, 4- [ (4-butyl-1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydronaphthyl ] butyl, 5- [ 5-pentyl- (1, 2, 3, 4, 6, 7 or 8-)1, 2, 3, 4-tetrahydronaphthyl ] pentyl, 6- [ 6-hexyl- (1, 2, 3, 4, 5, 7 or 8-)1, 2, 3, 4-tetrahydronaphthyl ] hexyl, 1-dimethyl-2- [1, 7-dimethyl- (1, 2, 3, 4, 5, 6 or 8-)1, 2, 3, 4-tetrahydronaphthyl ] ethyl and 2-methyl-3- [1, 1, 4-trimethyl- (2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydronaphthyl ] propyl.

Examples of the piperidyl group which may have 1 to 3 lower alkyl groups as substituents on the piperidine ring include a piperidyl group which may have 1 to 3 straight-chain or branched alkyl groups having 1 to 6 carbon atoms as substituents on the piperidine ring, such as a (1, 2, 3 or 4-) piperidyl group, 1-methyl- (2, 3 or 4-) piperidyl group, 1-ethyl- (2, 3 or 4-) piperidyl group, 1-propyl- (2, 3 or 4-) piperidyl group, 1-isopropyl- (2, 3 or 4-) piperidyl group, 1-butyl- (2, 3 or 4-) piperidyl group, 1-isobutyl- (2, 3 or 4-) piperidyl group, 1-tert-butyl- (2, 3 or 4-) piperidyl group, 1-pentyl- (2, 4-), 3 or 4-) piperidinyl, 1-hexyl- (2, 3 or 4-) piperidinyl, 1, 2-dimethyl- (3, 4, 5 or 6-) piperidinyl and 1, 2, 6-trimethyl- (3, 4 or 5-) piperidinyl.

Examples of the quinolyl lower alkyl group include quinolyl alkyl groups in which the alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as (2, 3, 4, 5, 6, 7 or 8-) quinolyl methyl group, 2- [ (2, 3, 4, 5, 6, 7 or 8-) quinolyl ] ethyl group, 1- [ (2, 3, 4, 5, 6, 7 or 8-) quinolyl ] ethyl group, 3- [ (2, 3, 4, 5, 6, 7 or 8-) quinolyl ] propyl group, 4- [ (2, 3, 4, 5, 6, 7 or 8-) quinolyl ] butyl group, 5- [ (2, 3, 4, 5, 6, 7 or 8-) quinolyl ] pentyl group and 6- [ (2, 3, 4, 5, 6, 7 or 8-) quinolyl ] hexyl group.

Examples of the 1, 2, 3, 4-tetrazolyl lower alkyl group which may have a substituent selected from the group consisting of a lower alkyl group and a phenyl lower alkyl group on the tetrazole ring include a 1, 2, 3, 4-tetrazolyl alkyl group whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms and which may have a substituent selected from the group consisting of a straight or branched alkyl group having 1 to 6 carbon atoms and a phenyl alkyl group whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms on the tetrazole ring, such as [ (1 or 5-)1, 2, 3, 4-tetrazolyl ] methyl, 2- [ (1 or 5-)1, 2, 3, 4-tetrazolyl ] ethyl, 1- [ (1 or 5-)1, 2, 3, 4-tetrazolyl ] ethyl, 3- [ (1 or 5-)1, 2, 3, 4-tetrazolyl ] propyl, 4- [ (1 or 5-)1, 2, 3, 4-tetrazolyl ] butyl, 5- [ (1 or 5-)1, 2, 3, 4-tetrazolyl ] pentyl, 6- [ (1 or 5-)1, 2, 3, 4-tetrazolyl ] hexyl, 5- [ 1-methyl-5- (1, 2, 3, 4-tetrazolyl) ] pentyl, 6- [ 1-methyl-5- (1, 2, 3, 4-tetrazolyl) ] hexyl, 5-methyl-1- (1, 2, 3, 4-tetrazolyl) methyl, 2- [ 5-ethyl-1- (1, 2, 3, 4-tetrazolyl ] hexyl, 1-dimethyl-2- [ (1 or 5-)1, 2, 3, 4-tetrazolyl) ] ethyl group, 2-methyl-3- [ (1 or 5-)1, 2, 3, 4-tetrazolyl ] propyl group, [ 1-methyl-5- (1, 2, 3, 4-tetrazolyl) ] methyl group, [ 1-ethyl-5- (1, 2, 3, 4-tetrazolyl) ] methyl group, 2- [ 1-propyl-5- (1, 2, 3, 4-tetrazolyl) ] ethyl group, 1- [ 1-butyl-5- (1, 2, 3, 4-tetrazolyl) ] ethyl group, 3- [ 1-pentyl-5- (1, 2, 3, 4-tetrazolyl) ] propyl group, 3- [ 5-propyl-1- (1, 2, 3, 4-tetrazolyl) ] propyl group, 4-tetrazolyl) ] propyl group, 4- [ 5-butyl-1- (1, 2, 3, 4-tetrazolyl) ] butyl group, 5- [ 5-pentyl-1- (1, 2, 3, 4-tetrazolyl) ] pentyl group, 6- [ 5-hexyl-1- (1, 2, 3, 4-tetrazolyl) ] hexyl group, [ 1-ethyl-5- (1, 2, 3, 4-tetrazolyl) ] methyl group, [ 1-benzyl-5- (1, 2, 3, 4-tetrazolyl) ] methyl group, 1- [ (2-phenylethyl) -5- (1, 2, 3, 4-tetrazolyl) ] methyl group, 2- [1- (3-phenylpropyl) -5- (1, 2, 3, 4-tetrazolyl) ] ethyl, 1- [1- (4-phenylbutyl) -5- (1, 2, 3, 4-tetrazolyl) ] ethyl, 3- [1- (5-phenylpentyl) -5- (1, 2, 3, 4-tetrazolyl) ] propyl, 4- [1- (6-phenylhexyl) -5- (1, 2, 3, 4-tetrazolyl) ] butyl, 5- [1- (1, 1-dimethyl-2-phenylethyl) -5- (1, 2, 3, 4-tetrazolyl) ] methyl, 6- [1- (2-methyl-3-phenylpropyl) -5- (1, 2, 3, 4-tetrazolyl) ] hexyl, and mixtures thereof, 5-benzyl-1- (1, 2, 3, 4-tetrazolyl) methyl, 2- [5- (1-phenylethyl) -1- (1, 2, 3, 4-tetrazolyl) ] ethyl, 3- [5- (3-phenylpropyl) -1- (1, 2, 3, 4-tetrazolyl) ] propyl, 4- [5- (4-phenylbutyl) -1- (1, 2, 3, 4-tetrazolyl) ] butyl, 5- [5- (5-phenylpentyl) -1- (1, 2, 3, 4-tetrazolyl) ] pentyl and 6- [5- (6-phenylhexyl) -1- (1, 2, 3, 4-tetrazolyl) ] hexyl.

Examples of the thiazolyl lower alkyl group which may have a phenyl group as a substituent on the thiazole ring include a thiazolyl alkyl group which may have 1 or 2 phenyl groups as substituents on the thiazole ring and the alkyl moiety thereof is a straight or branched alkyl group having 1 to 6 carbon atoms, such as [ (2, 4 or 5-) thiazolyl ] methyl, 2- [ (2, 4 or 5-) thiazolyl ] ethyl, 1- [ (2, 4 or 5-) thiazolyl ] ethyl, 3- [ (2, 4 or 5-) thiazolyl ] propyl, 4- [ (2, 4 or 5-) thiazolyl ] butyl, 5- [ (2, 4 or 5-) thiazolyl ] pentyl, 6- [ (2, 4 or 5-) thiazolyl ] hexyl, 1-dimethyl-2- [ (2, 4 or 5-) thiazolyl ] ethyl, thiazolyl, 2-methyl-3- [ (2, 4 or 5-) thiazolyl ] propyl, [ 2-phenyl- (4 or 5-) thiazolyl ] methyl, 2- [ 4-phenyl- (2 or 5-) thiazolyl ] ethyl, 1- [ 5-phenyl- (2 or 4-) thiazolyl ] ethyl, 3- [ 2-phenyl- (2 or 5-) thiazolyl ] propyl, 4- (2, 4-diphenyl-5-thiazolyl) butyl, 5- (2, 5-diphenyl-4-thiazolyl) pentyl, 6- (4, 5-diphenyl-2-thiazolyl) hexyl, 1-dimethyl-2- [ 2-phenyl- (4 or 5-) thiazolyl ] ethyl, methyl, ethyl, propyl, butyl, pentyl, hexyl, thiazolyl, 2-methyl-3- [ 4-phenyl- (2 or 5-) thiazolyl ] propyl, [ 4-phenyl- (2 or 5-) thiazolyl ] methyl, [ 5-phenyl- (2 or 4-) thiazolyl ] methyl, (2, 4-diphenyl-5-thiazolyl) methyl, (2, 5-diphenyl-4-thiazolyl) methyl, and (4, 5-diphenyl-2-thiazolyl) methyl.

Examples of the benzoyl lower alkyl group which may have 1 to 3 substituents selected from the group consisting of a lower alkoxy group and a halogen atom on the benzene ring include benzoylalkyl groups which may have 1 to 3 substituents selected from the group consisting of a straight-chain or branched alkoxy group having 1 to 6 carbon atoms and a halogen atom on the benzene ring and whose alkyl moiety is a branched or branched alkyl group having 1 to 6 carbon atoms, such as benzoylmethyl group, 2-benzoylethyl group, 1-benzoylethyl group, 3-benzoylpropyl group, 4-benzoylbutyl group, 5-benzoylpentyl group, 6-benzoylhexyl group, 1-dimethyl-2-benzoylethyl group, 2-methyl-3-benzoylpropyl group, 4-fluorobenzoylmethyl group, 2-chlorobenzoylmethyl group, 3-chlorobenzoylmethyl, 4-chlorobenzoylmethyl, 2- (4-fluorobenzoyl) ethyl, 2- (4-chlorobenzoyl) ethyl, 3, 4-dibromobenzoylmethyl, 3, 4-diiodobenzoylmethyl, 2, 4-difluorobenzoylmethyl, 2, 5-dichlorobenzoylmethyl, 2, 6-dichlorobenzoylmethyl, 3, 4, 5-trifluorobenzoylmethyl, 3- (4-chlorobenzoyl) propyl, 1- (2-bromobenzoyl) ethyl, 4- (3-fluorobenzoyl) butyl, 5- (4-iodobenzoyl) pentyl, 6- (4-chlorobenzoyl) hexyl, 1-dimethyl-2- (3-fluorobenzoyl) ethyl, m, 2-methyl-3- (4-chlorobenzoyl) propyl group, 2-methoxybenzoyl methyl group, 2- (3-methoxybenzoyl) ethyl group, 2- (4-methoxybenzoyl) ethyl group, 4-methoxybenzoyl methyl group, 1- (2-ethoxybenzoyl) ethyl group, 3- (3-ethoxybenzoyl) propyl group, 4- (4-ethoxybenzoyl) butyl group, 5- (4-isopropoxybenzoyl) pentyl group, 6- (3-butoxybenzoyl) hexyl group, 1-dimethyl-2- (4-pentyloxybenzoyl) ethyl group, 2-methyl-3- (4-hexyloxybenzoyl) propyl group, methyl-2- (4-hexyloxybenzoyl) hexyl group, methyl, 3, 4-dimethoxybenzoylmethyl group, 3, 4-diethoxybenzoylmethyl group, 2, 4-dimethoxybenzoylmethyl group, 2, 5-dimethoxybenzoylmethyl group, 2, 6-dimethoxybenzoylmethyl group, 3, 4, 5-trimethoxybenzoylmethyl group, 2-chloro-4-methoxybenzoylmethyl group and 3-fluoro-5-ethoxybenzoylmethyl group.

Examples of the piperidyl lower alkyl group which may have a lower alkyl group as a substituent on the piperidine ring include a piperidyl alkyl group which may have 1 to 3 straight-chain or branched alkyl groups having 1 to 6 carbon atoms as substituents on the piperidine ring and whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as [ (1, 2, 3 or 4-) piperidyl ] methyl, 2- [ (1, 2, 3 or 4-) piperidyl ] ethyl, 1- [ (1, 2, 3 or 4-) piperidyl ] ethyl, 3- [ (1, 2, 3 or 4-) piperidyl ] propyl, 4- [ (1, 2, 3 or 4-) piperidyl ] butyl, 5- [ (1, 2, 3 or 4-) piperidyl ] pentyl, 6- [ (1, 2, 3 or 4-) piperidyl ] hexyl, hexyl, 1, 1-dimethyl-2- [ (1, 2, 3 or 4-) piperidinyl ] ethyl, 2-methyl-3- [ (1, 2, 3 or 4-) piperidinyl ] propyl, [ 1-methyl- (2, 3 or 4-) piperidinyl ] methyl, 2- [ 1-ethyl- (2, 3 or 4-) piperidinyl ] ethyl, 1- [ 4-propyl- (1, 2 or 3-) piperidinyl ] ethyl, 3- [ 3-isopropyl- (1, 2, 4, 5 or 6-) piperidinyl ] propyl, 4- [ 2-butyl- (1, 3, 4, 5 or 6-) piperidinyl ] butyl, 5- [ 1-isobutyl- (2, 3 or 4-) piperidinyl ] pentyl, and so forth, 6- [ 1-tert-butyl- (2, 3 or 4-) piperidinyl ] hexyl, 1-dimethyl-2- [ 4-pentyl- (1, 2 or 3-) piperidinyl ] ethyl, 2-methyl-3- [ 1-hexyl- (2, 3 or 4-) piperidinyl ] propyl, [1, 2-dimethyl- (3, 4, 5 or 6-) piperidinyl ] methyl and [1, 2, 6-trimethyl- (3, 4 or 5-) piperidinyl ] methyl.

Examples of the imidazole group which may have 1 to 3 phenyl groups as substituents on the imidazole ring include imidazole groups which may have 1 to 3 phenyl groups as substituents on the imidazole ring, such as (1, 2, 4 or 5-) imidazole group, 1-phenyl- (2, 4 or 5-) imidazole group, 2-phenyl- (1, 4 or 5-) imidazole group, 4-phenyl- (1, 2 or 5-) imidazole group, 5-phenyl- (1, 2 or 4-) imidazole group, 1, 2-diphenyl- (4 or 5-) imidazole group, 2, 4-diphenyl- (1 or 5-) imidazole group, 4, 5-diphenyl- (1 or 2-) imidazole group, 2, 5-diphenyl- (1 or 4-) imidazole group and 2, 4, 5-triphenyl-1-imidazolyl.

Examples of the benzimidazolyl group which may have 1 to 3 lower alkyl groups as substituents on the benzimidazole ring include benzimidazolyl groups which may have 1 to 3 straight-chain or branched alkyl groups having 1 to 6 carbon atoms as substituents on the benzimidazole ring, such as (1, 2, 4, 5, 6 or 7-) benzimidazolyl, 1-methyl- (2, 4, 5, 6 or 7-) benzimidazolyl, 2-ethyl- (1, 4, 5, 6 or 7-) benzimidazolyl, 4-propyl- (1, 2, 5, 6 or 7-) benzimidazolyl, 5-butyl- (1, 2, 4, 6 or 7-) benzimidazolyl, 6-pentyl- (1, 2, 4, 5 or 7-) benzimidazolyl, 7-hexyl- (1, 7-), 2. 4, 5 or 6-) benzimidazolyl, 1-ethyl- (2, 4, 5, 6 or 7-) benzimidazolyl ] hexyl, 1-butyl- (2, 4, 5, 6 or 7-) benzimidazolyl, 1-isopropyl- (1, 2, 4, 5, 6 or 7-) benzimidazolyl, 1, 2-dimethyl- (4, 5, 6 or 7-) benzimidazolyl, 1-methyl-4-ethyl- (2, 5, 6 or 7-) benzimidazolyl, 1-propyl-5-methyl- (2, 4, 6 or 7-) benzimidazolyl and 1, 2, 5-trimethyl- (2, 4, 5, 6 or 7-) benzimidazolyl.

Examples of pyridyl lower alkoxy include pyridylalkoxy whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as (2, 3 or 4-) pyridylmethoxy, 2- [ (2, 3 or 4-) pyridyl ] ethoxy, 1- [ (2, 3 or 4-) pyridyl ] ethoxy, 3- [ (2, 3 or 4-) pyridyl ] propoxy, 4- [ (2, 3 or 4-) pyridyl ] butoxy, 1-1-dimethyl-2- [ (2, 3 or 4-) pyridyl ] ethoxy, 5- [ (2, 3 or 4-) pyridyl ] pentoxy, 6- [ (2, 3 or 4-) pyridyl ] hexoxy, 1- [ (2, 3 or 4-) pyridyl ] isopropoxy and 2-methyl-3- [ (2, 3 or 4-) pyridyl ] isopropoxy, 3 or 4-) pyridyl ] propoxy.

Examples of the 1, 2, 3, 4-tetrahydroquinolyl lower alkyl group which may have an oxy group as a substituent on the tetrahydroquinoline ring include a 1, 2, 3, 4-tetrahydroquinolyl alkyl group which may have 1 or 2 oxy groups as substituents on the tetrahydroquinoline ring and whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl methyl, 2- [ (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl ] ethyl, 1- [ (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl ] ethyl, 3- [ (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl propyl, 4- [ (1, 2, 3, 4, 5, 6, 7, or 8-)1, 2, 3, 4-tetrahydroquinolyl ] butyl, 5- [ (1, 2, 3, 4, 5, 6, 7, or 8-)1, 2, 3, 4-tetrahydroquinolyl ] pentyl, 6- [ (1, 2, 3, 4, 5, 6, 7, or 8-)1, 2, 3, 4-tetrahydroquinolyl ] hexyl, 1-dimethyl-2- [ (1, 2, 3, 4, 5, 6, 7, or 8-)1, 2, 3, 4-tetrahydroquinolyl ] ethyl, 2-methyl-3- [ (1, 2, 3, 4, 5, 6, 7, or 8-)1, 2, 3, 4-tetrahydroquinolyl ] propyl, 4- [ (1, 2, 3, 4, 5, 6, 7, or 8-), [ 2-oxo- (1, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl ] methyl, [ 4-oxo- (1, 2, 3, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl ] methyl, [2, 4-dioxo- (1, 3, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl ] methyl, 2- [ 2-oxo- (1, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl ] ethyl, 3- [ 4-oxo- (1, 2, 3, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl ] propyl, 4- [2, 4-dioxo- (1, 4, 1, 3, 4-tetrahydroquinolyl, 3. 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl butyl, 5- [ 2-oxo- (1, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl ] pentyl and 6- [ 4-oxo- (1, 2, 3, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl ] hexyl.

Examples of the 1, 3, 4-oxadiazolyl lower alkyl group which may have an oxy group as a substituent on the 1, 3, 4-oxadiazolyl ring include 1, 3, 4-oxadiazolyl alkyl groups which may have an oxy group as a substituent on the 1, 3, 4-oxadiazolyl ring and whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as (2 or 5-)1, 3, 4-oxadiazolyl methyl, 2- [ (2 or 5-)1, 3, 4-oxadiazolyl ] ethyl, 1- [ (2 or 5-)1, 3, 4-oxadiazolyl ] ethyl, 3- [ (2 or 5-)1, 3, 4-oxadiazolyl ] propyl, 4- [ (2 or 5-)1, 3, 4-oxadiazolyl ] butyl, 5- [ (2 or 5-)1, 3, 4-oxadiazolyl ] pentyl, 6- [ (2 or 5-)1, 3, 4-oxadiazolyl ] hexyl, 1-dimethyl-2- [ (2 or 5-)1, 3, 4-oxadiazolyl ] ethyl, 2-methyl-3- [ (2 or 5-)1, 3, 4-oxadiazolyl ] propyl, 2-oxo- [ (3 or 5-)1, 3, 4-oxadiazolyl ] methyl, 5-oxo- [ (2 or 3-)1, 3, 4-oxadiazolyl ] methyl, 2- [ 2-oxo- (3 or 5-) (1, 3, 4-oxadiazolyl) ] ethyl, 1- [ 5-oxo- (2 or 3-)1, 3, 4-oxadiazolyl ] ethyl, oxadiazolyl ] hexyl, oxadiazolyl ] ethyl, oxadiazolyl ] propyl, oxa-2-methyl, oxadiazolyl, oxa-2, 3- [ (2 or 5-)1, 3, 4-oxadiazolyl ] propyl, 4- [ 2-oxo (3 or 5-)1, 3, 4-oxadiazolyl ] butyl, 5- [ 5-oxo (2 or 3-)1, 3, 4-oxadiazolyl ] pentyl, 6- [ 2-oxo (3 or 5-)1, 3, 4-oxadiazolyl ] hexyl, 1-dimethyl-2- [ 5-oxo (2 or 3-)1, 3, 4-oxadiazolyl ] ethyl and 2-methyl-3- [ 2-oxo (3 or 5-)1, 3, 4-oxadiazolyl ] propyl.

Examples of the thienyl lower alkyl group include thienyl alkyl groups in which the alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms, such as (2 or 3-) thienylmethyl group, 2- [ (2 or 3-) thienyl ] ethyl group, 1- [ (2 or 3-) thienyl ] ethyl group, 3- [ (2 or 3-) thienyl ] propyl group, 4- [ (2 or 3-) thienyl ] butyl group, 5- [ (2 or 3-) thienyl ] pentyl group, 6- [ (2 or 3-) thienyl ] hexyl group, 1-dimethyl-2- [ (2 or 3-) thienyl ] ethyl group and 2-methyl-3- [ (2 or 3-) thienyl ] propyl group.

Examples of the pyrimidylcarbonyl group which may have an oxy group as a substituent on the pyrimidine ring include pyrimidylcarbonyl groups which may have 1 to 3 oxy groups as substituents on the pyrimidine ring, such as (2, 3, 4 or 6-) pyrimidylcarbonyl, 2, 6-dioxo- (1, 3, 4 or 5-) pyrimidylcarbonyl, 2-oxo- (1, 3, 4, 5 or 6-) pyrimidylcarbonyl, 6-oxo- (1, 2, 3, 4 or 5-) pyrimidylcarbonyl, 4-oxo- (1, 2, 3, 5 or 6-) pyrimidylcarbonyl, 2, 4-dioxo- (1, 3, 4 or 6-) pyrimidylcarbonyl and 2, 4, 6-trioxo- (1, 3 or 5-) pyrimidylcarbonyl.

Examples of the lower alkoxy group include linear or branched alkoxy groups having 1 to 6 carbon atoms which may have a linear or branched alkoxy group having 1 to 6 carbon atoms as a substituent, such as methoxymethoxy group, 1-ethoxyethoxy group, 2-methoxyethoxy group, 2-propoxyethoxy group, 3-isopropoxypropoxy group, 4-butoxybutoxy group, 5-pentoxypentyloxy group, 6-hexoxyhexyloxy group, 1-dimethyl-2-methoxyethoxy group, 2-methyl-3-ethoxypropoxy group and 3-methoxypropoxy group.

Examples of the lower alkoxycarbonyl lower alkoxy group include alkoxycarbonylalkoxy groups in which both alkoxy moieties are straight-chain or branched alkoxy groups having 1 to 6 carbon atoms, such as methoxycarbonylmethoxy, ethoxycarbonylmethoxy, 2-methoxycarbonylethoxy, 2-ethoxycarbonylethoxy, 1-ethoxycarbonylethoxy, 3-methoxycarbonylpropoxy, 3-ethoxycarbonylpropoxy, 4-ethoxycarbonylbutoxy, 5-isopropoxycarbonylpentyloxy, 6-propoxycarbonylhexyloxy, 1-dimethyl-2-butoxycarbonylethoxy, 2-methyl-3-tert-butoxycarbonylpropoxy, 2-pentyloxycarbonylethoxy and hexyloxycarbonylmethoxy.

Examples of the carboxy lower alkoxy group include carboxyalkoxy groups whose alkoxy moiety is a linear or branched alkoxy group having 1 to 6 carbon atoms, such as carboxymethoxy group, 2-carboxyethoxy group, 1-carboxyethoxy group, 3-carboxypropoxy group, 4-carboxybutoxy group, 5-carboxypentyloxy group, 6-carboxyhexyloxy group, 1-dimethyl-2-carboxyethoxy group and 2-methyl-3-carboxypropoxy group.

Examples of the phenoxy lower alkanoyl group include phenoxy alkanoyl groups whose alkanoyl moiety is a straight-chain or branched alkanoyl group having 2 to 6 carbon atoms, such as 2-phenoxyacetyl, 3-phenoxypropionyl, 2-phenoxypropionyl, 4-phenoxybutyryl, 5-phenoxyvaleryl, 6-phenoxyhexanoyl, 2-dimethyl-2-phenoxypropionyl and 2-methyl-3-phenoxypropionyl.

Examples of the 1, 2, 3, 4-tetrahydroquinolylcarbonyl group which may have an oxy group as a substituent on the tetrahydroquinoline ring include a 1, 2, 3, 4-tetrahydroquinolylcarbonyl group which may have 1 or 2 oxy groups as substituents on the tetrahydroquinoline ring, for example [ (1, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl ] carbonyl, [ 2-oxo- (1, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl ] carbonyl, [ 4-oxo- (1, 2, 3, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl ] carbonyl and [2, 4-dioxo- (1, 3, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl ] carbonyl.

Examples of the 1, 2, 3, 4-tetrahydroquinolyl group which may have an oxy group as a substituent on the tetrahydroquinoline ring include 1, 2, 3, 4-tetrahydroquinolyl groups which may have 1 or 2 oxy groups as substituents on the tetrahydroquinoline ring, such as (1, 2, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl, 2-oxo- (1, 3, 4, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl, 4-oxo- (1, 2, 3, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl and 2, 4-dioxo- (1, 3, 5, 6, 7 or 8-)1, 2, 3, 4-tetrahydroquinolyl.

Examples of the amino group which may have a lower alkoxycarbonyl group as a substituent include amino groups of an alkoxycarbonyl group which may have a linear or branched alkoxy group whose alkoxy moiety is 1 to 6 carbon atoms, such as amino, methoxycarbonylamino, ethoxycarbonylamino, propoxycarbonylamino, isopropoxycarbonylamino, butoxycarbonylamino, tert-butoxycarbonylamino, pentyloxycarbonylamino and hexyloxycarbonylamino.

Examples of the benzoyl group which may have 1 to 3 lower alkoxy groups as a substituent on the benzene ring include benzoyl groups which may have 1 to 3 straight-chain or branched alkoxy groups having 1 to 6 carbon atoms as substituents on the benzene ring, such as benzoyl group, 2-methoxybenzoyl group, 3-methoxybenzoyl group, 4-methoxybenzoyl group, 2-ethoxybenzoyl group, 3-ethoxybenzoyl group, 4-isopropoxybenzoyl group, 3-butoxybenzoyl group, 4-pentyloxybenzoyl group, 4-hexyloxybenzoyl group, 3, 4-dimethoxybenzoyl group, 3, 4-diethoxybenzoyl group, 2, 4-dimethoxybenzoyl group, 2, 5-dimethoxybenzoyl group, p, 2, 6-dimethoxybenzoyl and 3, 4, 5-trimethoxybenzoyl.

Examples of the lower alkyl group which may have 1 or 2 phenyl groups which may have 1 to 3 substituents selected from the group consisting of a lower alkoxycarbonyl group, a cyano group, a nitro group, a phenyl group, a halogen atom, a lower alkyl group which may have a halogen atom as a substituent, a lower alkoxy group which may have a halogen atom as a substituent and a lower alkylthio group on the benzene ring include, in addition to the above phenyl lower alkyl group, alkoxycarbonyl groups which have 1 to 6 carbon atoms and 1 or 2 phenyl groups which may have 1 to 3 substituents selected from the group consisting of a straight-chain or branched alkoxy group whose alkoxy moiety is a straight-chain or branched alkoxy group having 1 to 6 carbon atoms, cyano groups, nitro groups, phenyl groups, halogen atoms, a straight-chain or branched alkyl group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent, a straight-chain or branched alkoxy group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent, and a straight-chain or branched alkylthio group having 1 to 6 carbon atoms Straight-chain or branched alkyl groups, for example, 1, 1-diphenylmethyl, 1, 1-bis (4-fluorophenyl) methyl, 1-phenyl-1- (4-methoxyphenyl) methyl, 3-diphenylpropyl, 2, 5-difluorobenzyl, 2, 4-difluorobenzyl, 3, 5-difluorobenzyl, 2, 6-difluorobenzyl, 3-trifluoromethylbenzyl, 2-trifluoromethylbenzyl, 4-trifluoromethylbenzyl, 3, 4-dimethoxybenzyl, 3, 5-dimethoxybenzyl, 2-chlorophenylmethyl, 3-chlorophenylmethyl, 4-chlorophenylmethyl, 2-methylphenylmethyl, 3-methylphenylmethyl, 4-methylphenylmethyl, 3, 4-dimethylbenzyl group, 2, 3-dimethylbenzyl group, 2-methoxybenzyl group, 3-methoxybenzyl group, 4-cyanobenzyl group, 2-cyanobenzyl group, 3-cyanobenzyl group, 4-methoxybenzyl group, 2, 3-dichlorobenzyl group, 2, 4-dichlorobenzyl group, 2, 5-dichlorobenzyl group, 3, 4-dichlorobenzyl group, 2, 6-dichlorobenzyl group, 4-fluorobenzyl group, 3-fluorobenzyl group, 2-fluorobenzyl group, 4-nitrobenzyl group, 3-nitrobenzyl group, 2-nitrobenzyl group, 3-trifluoromethoxybenzyl group, 4-trifluoromethoxybenzyl group, 2-trifluoromethoxybenzyl group, 4-methoxycarbonylbenzyl group, 3-methoxycarbonylbenzyl, 4-tert-butylbenzyl, 4-ethylbenzyl, 4-isopropylbenzyl, 4-methoxy-3-chlorophenylmethyl, 2- (4-methoxyphenyl) ethyl, 2- (4-fluorophenyl) ethyl, 2- (4-chlorophenyl) ethyl, 2- (3-methoxyphenyl) ethyl, 2- (4-methylphenyl) ethyl, 4-phenylbenzyl, 3-diphenylpropyl, 3-methyl-4-nitrobenzyl, 4- (4-methoxyphenyl) butyl, 2- (4-methylphenyl) ethyl, 4-tert-butoxycarbonylbenzyl, 3-chloro-6-methoxybenzyl, 4-nitro-3-methylbenzyl, methyl, ethyl, isopropyl, 4-tert-butyrylphenylmethyl group, 2- (2-ethoxycarbonylphenyl) ethyl group, 1- (3-propoxycarbonylphenyl) ethyl group, 3- (4-pentyloxycarbonylphenyl) propyl group, 4- (3-hexyloxycarbonylphenyl) butyl group, 5- (3, 4-dimethoxycarbonylphenyl) pentyl group, 6- (3, 4, 5-diethoxycarbonylphenyl) hexyl group, 1-dimethyl-2- (4-butoxycarbonylphenyl) ethyl group, 2-methyl-3- (4-methoxycarbonylphenyl) propyl group, 2- (2-cyanophenyl) ethyl group, 1- (3-cyanophenyl) ethyl group, 3- (4-cyanophenyl) propyl group, 4- (2-cyanophenyl) butyl group, methyl group, ethyl group, propyl group, pentyl group, hexyl, 5- (3-cyanophenyl) pentyl, 6- (4-cyanophenyl) hexyl, 1-dimethyl-2- (2, 4-dicyanophenyl) ethyl, 2-methyl-3- (2, 4, 6-tricyanophenyl) propyl, 2- (2-nitrophenyl) ethyl, 1- (3-nitrophenyl) ethyl, 3- (4-nitrophenyl) propyl, 4- (2-nitrophenyl) butyl, 5- (3-nitrophenyl) pentyl, 6- (4-nitrophenyl) hexyl, 1-dimethyl-2- (2, 4-dinitrophenyl) ethyl, 2-methyl-3- (2, 4, 6-trinitrophenyl) propyl, methyl-2, 2- (2-phenylphenyl) ethyl, 1- (3-phenylphenyl) ethyl, 3- (4-phenylphenyl) propyl, 4- (2-phenylphenyl) butyl, 5- (3-phenylphenyl) pentyl, 6- (4-phenylphenyl) hexyl, 1-dimethyl-2- (2, 4-diphenylphenyl) ethyl, 2-methyl-3- (2, 4, 6-triphenylphenyl) propyl, 2- (2-fluorophenyl) ethyl, 1- (3-bromophenyl) ethyl, 3- (4-iodophenyl) propyl, 4- (2-bromophenyl) butyl, 5- (3-chlorophenyl) pentyl, 6- (4-bromophenyl) hexyl, methyl-ethyl, propyl, butyl, pentyl, hexyl, and the like, 1, 1-dimethyl-2- (2, 4-dichlorophenyl) ethyl, 2-methyl-3- (2, 4, 6-trifluorophenyl) propyl, 2- (2-ethylphenyl) ethyl, 1- (3-propylphenyl) ethyl, 3- (4-butylphenyl) propyl, 4- (2-pentylphenyl) butyl, 5- (3-hexylphenyl) pentyl, 6- (4-trifluoromethylphenyl) hexyl, 1-dimethyl-2- (2, 4-dimethylphenyl) ethyl, 2-methyl-3- [2, 4, 6-tris (trifluoromethyl) phenyl ] propyl, 2- (2-ethoxyphenyl) ethyl, 1- (3-propoxyphenyl) ethyl, 3- (4-butoxyphenyl) propyl, 4- (2-pentyloxyphenyl) butyl, 5- (3-hexyloxyphenyl) pentyl, 6- (4-trifluoromethoxyphenyl) hexyl, 1-dimethyl-2- (2, 4-dimethoxyphenyl) ethyl, 2-methyl-3- [2, 4, 6-tris (trifluoromethoxy) phenyl ] propyl, 2-methylthiobenzyl, 3-methylthiobenzyl, 4-methylthiobenzyl, 3, 4-dimethylthiobenzyl, 2, 3-dimethylthiobenzyl, 2- (2-ethylthiophenyl) ethyl, 2- (4-methylthiophenyl) ethyl, 1- (3-propylthiophenyl) ethyl, methyl, propyl, butyl, pentyl, hexyl, 2- (3-trifluoromethylphenyl) ethyl, pentyl, hexyl, 2-methyl-3- [2, 4, 6-tris (, 3- (4-butylthiophenyl) propyl, 4- (2-pentylthiophenyl) butyl, 5- (3-hexylthiophenyl) pentyl, 6- (4-methylthiophenyl) hexyl, 1-dimethyl-2- (2, 4-dimethylthiophenyl) ethyl, 2-methyl-3- [2, 4, 6-trimethylthiophenyl ] propyl, 2-methyl-4-cyanobenzyl, 3-ethoxy-4-ethoxycarbonylbenzyl, 4-phenyl-3-nitrobenzyl, 3-fluoro-4-methoxybenzyl, 4-trifluoromethyl-3-cyanobenzyl, and 3-trifluoromethoxy-3-fluorobenzyl.

Examples of the phenyl group which may have 1 to 3 groups selected from a lower alkoxy group which may have a halogen atom as a substituent and a lower alkyl group which may have a halogen atom as a substituent on the phenyl ring include phenyl groups which may have 1 to 3 groups selected from a straight-chain or branched alkoxy group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent and a straight-chain or branched alkyl group having 1 to 6 carbon atoms which may have 1 to 3 halogen atoms as a substituent on the phenyl ring, such as phenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2-ethylphenyl, 3-ethylphenyl, 4-isopropylphenyl, 3-butylphenyl, 4-pentylphenyl, 4-hexylphenyl, 3, 4-dimethylphenyl, 3, 4-diethylphenyl group, 2, 4-dimethylphenyl group, 2, 5-dimethylphenyl group, 2, 6-dimethylphenyl group, 3, 4, 5-trimethylphenyl group, 2-methoxyphenyl group, 3-methoxyphenyl group, 4-methoxyphenyl group, 2-ethoxyphenyl group, 3-ethoxyphenyl group, 4-isopropoxyphenyl group, 3-butoxyphenyl group, 4-pentyloxyphenyl group, 4-hexyloxyphenyl group, 3, 4-dimethoxyphenyl group, 3, 4-diethoxyphenyl group, 2, 4-dimethoxyphenyl group, 2, 5-dimethoxyphenyl group, 2, 6-dimethoxyphenyl group, 3, 4, 5-trimethoxyphenyl group, 2-trifluoromethoxyphenyl group, 3-trifluoromethoxyphenyl group, 2-ethoxyphenyl group, 4-dimethoxyphenyl group, 3-ethoxyphenyl group, 4-trifluoromethoxyphenyl group, 2- (bromomethoxy) phenyl group, 3- (2-chloroethoxy) phenyl group, 4- (2, 3-dichloropropoxy) phenyl group, 4- (4-fluorobutoxy) phenyl group, 3- (5-chloropentyloxy) phenyl group, 4- (5-bromohexyloxy) phenyl group, 4- (5, 6-dibromohexyloxy) phenyl group, 3, 4-bis (trifluoromethoxy) phenyl group, 3, 4-bis (4, 4, 4-trichlorobutoxy) phenyl group, 2, 4-bis (3-chloro-2-methoxypropyl) phenyl group, 2, 5-bis (3-chloropropyloxy) phenyl group, 2, 6-bis (2, 2, 2-trifluoroethoxy) phenyl group, 3, 4, 5-tris (trifluoromethoxy) phenyl group, 4- (2, 2, 2-trichloroethoxy) phenyl, 2-methyl-4-trifluoromethoxyphenyl, 3-ethyl-4-trichloromethoxyphenyl, 2-methoxy-4-trifluoromethoxyphenyl, 3-ethoxy-4-trichloromethoxyphenyl, 2-trifluoromethylphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 2- (bromomethyl) phenyl, 3- (2-chloroethyl) phenyl, 4- (2, 3-dichloropropyl) phenyl, 4- (4-fluorobutyl) phenyl, 3- (5-chloropentyl) phenyl, 4- (5-bromohexyl) phenyl, 4- (5, 6-dibromohexyl) phenyl, 3, 4-bis (trifluoromethyl) phenyl, 3, 4-bis (4, 4, 4-trichlorobutyl) phenyl, 2, 4-bis (3-chloro-2-methylpropyl) phenyl, 2, 5-bis (3-chloropropyl) phenyl, 2, 6-bis (2, 2, 2-trifluoroethyl) phenyl, 3, 4, 5-tris (trifluoromethyl) phenyl, 4- (2, 2, 2-trichloroethyl) phenyl, 2-methyl-4-trifluoromethylphenyl and 3-ethyl-4-trichloromethylphenyl.

Examples of the pyrrolidinyl lower alkyl group which may have 1 to 3 lower alkyl groups which may have a hydroxyl group as a substituent on the pyrrolidine ring include pyrrolidinyl alkyl groups which may have 1 to 3 straight-chain or branched alkyl groups having 1 to 6 carbon atoms which may have 1 to 3 hydroxyl groups as substituents on the pyrrolidine ring and whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as [ (1, 2 or 3-) pyrrolidinyl ] methyl group, 2- [ (1, 2 or 3-) pyrrolidinyl ] ethyl group, 1- [ (1, 2 or 3-) pyrrolidinyl ] ethyl group, 3- [ (1, 2 or 3-) pyrrolidinyl ] propyl group, 4- [ (1, 2 or 3-) pyrrolidinyl ] butyl group, 5- [ (1, 2 or 3-) pyrrolidinyl ] pentyl group, 6- [ (1, 2, or 3-), 2 or 3-) pyrrolidinyl ] hexyl, 1-dimethyl-2- [ (1, 2 or 3-) pyrrolidinyl ] ethyl, 2-methyl-3- [ (1, 2 or 3-) pyrrolidinyl ] propyl, [ 1-methyl- (2 or 3-) pyrrolidinyl ] methyl, 2- [ 2-ethyl- (1, 3, 4 or 5-) pyrrolidinyl ] ethyl, 1- [ 3-propyl- (1, 2, 4 or 5-) pyrrolidinyl ] ethyl, 3- [ 1-butyl- (2 or 3-) pyrrolidinyl ] propyl, 4- [ 2-pentyl- (1, 3, 4 or 5-) pyrrolidinyl ] butyl, 5- [ 3-hexyl- (1, 2 or 3-), 2. 4 or 5-) pyrrolidinyl ] pentyl, 6- [1, 2-dimethyl- (3, 4 or 5-) pyrrolidinyl ] hexyl, 1-dimethyl-2- [1, 2, 3-trimethyl- (4 or 5-) pyrrolidinyl ] ethyl, 2-methyl-3- [ 1-ethyl-2-methyl- (3, 4 or 5-) pyrrolidinyl ] propyl, [1- (2-hydroxyethyl) - (2 or 3-) pyrrolidinyl ] methyl, [ 2-hydroxymethyl- (1, 3, 4 or 5-) pyrrolidinyl ] methyl, 2- [ 2-hydroxymethyl- (1, 3, 4 or 5-) pyrrolidinyl ] ethyl, 1- [3- (3-hydroxypropyl) - (1, 3, 5-), 2. 4 or 5-) pyrrolidinyl ] ethyl, 3- [1- (4-hydroxybutyl) - (2 or 3-) pyrrolidinyl ] propyl, 4- [2- (5-hydroxypentyl) - (1, 3, 4 or 5-) pyrrolidinyl ] butyl, 5- [3- (6-hydroxyhexyl) - (1, 2, 4 or 5-) pyrrolidinyl ] pentyl, 6- [1, 2-dimethylol- (3, 4 or 5-) pyrrolidinyl ] hexyl, 1-dimethyl-2- [1, 2, 3-trimethylol- (4 or 5-) pyrrolidinyl ] ethyl, 2-methyl-3- [2- (1, 2-hydroxyethyl) - (1, 5-), 3. 4 or 5-) pyrrolidinyl ] propyl and [2- (2, 3, 4-trihydroxybutyl) - (1, 3, 4 or 5-) pyrrolidinyl ] methyl.

Examples of the lower alkyl group substituted with an amino group which may have a substituent selected from the group consisting of a phenyl group and a lower alkyl group include a straight-chain or branched-chain alkyl group having 1 to 6 carbon atoms which is substituted with an amino group which may have 1 or 2 substituents selected from the group consisting of a phenyl group and a straight-chain or branched-chain alkyl group having 1 to 6 carbon atoms, such as an aminomethyl group, a 2-aminomethyl group, a 1-aminoethyl group, a 3-aminopropyl group, a 4-aminobutyl group, a 5-aminopentyl group, a 6-aminohexyl group, a 1, 1-dimethyl-2-aminoethyl group, an N, N-diethyl-2-aminoethyl group, a 2-methyl-3-aminopropyl group, a methylaminomethyl group, a 1-ethylaminoethyl group, a 2-propylaminoethyl group, a 3-isopropylaminopropyl group, a 4-butylaminobutyl group, a 5-, 6-hexylaminohexyl, dimethylaminomethyl, 2-diisopropylaminoethyl, (N-ethyl-N-propylamino) methyl, 2- (N-methyl-N-hexylamino) ethyl, phenylaminomethyl, 1-phenylaminoethyl, 2-phenylaminoethyl, 3-phenylaminopropyl, 4-phenylaminobutyl, 5-phenylaminopentyl, 6-phenylaminohexyl, N-methyl-N-phenylaminomethyl, 2- (N-ethyl-N-phenylamino) ethyl, (N-ethyl-N-phenylamino) methyl and 2- (N-methyl-N-phenylamino) ethyl.

Examples of the tetrahydrofuranyl lower alkyl group which may have a hydroxyl group as a substituent on the lower alkyl group include tetrahydrofuranyl alkyl groups which may have a hydroxyl group as a substituent on the lower alkyl group and whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as [ (2 or 3-) tetrahydrofuranyl ] methyl, 2- [ (2 or 3-) tetrahydrofuranyl ] ethyl, 1- [ (2 or 3-) tetrahydrofuranyl ] ethyl, 3- [ (2 or 3-) tetrahydrofuranyl ] propyl, 4- [ (2 or 3-) tetrahydrofuranyl ] butyl, 5- [ (2 or 3-) tetrahydrofuranyl ] pentyl, 6- [ (2 or 3-) tetrahydrofuranyl ] hexyl, 1-dimethyl-2- [ (2 or 3-) tetrahydrofuranyl ] ethyl, p, 2-methyl-3- [ (2 or 3-) tetrahydrofuryl ] propyl, 1-hydroxy-1- [ (2 or 3-) tetrahydrofuryl ] methyl, 2-hydroxy-2- [ (2 or 3-) tetrahydrofuryl ] ethyl, 2-hydroxy-1- [ (2 or 3-) tetrahydrofuryl ] ethyl, 3-hydroxy-3- [ (2 or 3-) tetrahydrofuryl ] propyl, 4-hydroxy-4- [ (2 or 3-) tetrahydrofuryl ] butyl, 5-hydroxy-5- [ (2 or 3-) tetrahydrofuryl ] pentyl, 6-hydroxy-6- [ (2 or 3-) tetrahydrofuryl ] hexyl, 2-hydroxy-1, 1-dimethyl-2- [ (2 or 3-) tetrahydrofuryl ] ethyl and 3-hydroxy-2-methyl-3- [ (2 or 3-) tetrahydrofuryl ] propyl.

Examples of the phenoxy lower alkyl group which may have 1 to 3 substituents selected from the group consisting of a lower alkyl group and a nitro group on the benzene ring include, in addition to the above phenoxy lower alkyl group, a phenoxyalkyl group which may have 1 to 3 substituents selected from the group consisting of a straight-chain or branched alkyl group having 1 to 6 carbon atoms and a nitro group on the benzene ring and the alkyl moiety of which is a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as 2-methylphenoxymethyl, 3-methylphenoxymethyl, 4-methylphenoxymethyl, 3, 4-dimethylphenoxymethyl, 2, 3-dimethylphenoxymethyl, 3, 4, 5-trimethylphenoxymethyl, 2- (2-ethylphenoxy) ethyl, 2- (3-methylphenoxy) ethyl, 2- (4-methylphenoxy) ethyl, 2- (3-, 1- (3-propylphenoxy) ethyl group, 3- (4-butylphenoxy) propyl group, 4- (2-pentylphenoxy) butyl group, 5- (3-hexylphenoxy) pentyl group, 6- (4-methylphenoxy) hexyl group, 1-dimethyl-2- (2, 4-dimethylphenoxy) ethyl group, 2-methyl-3- (2, 4, 6-trimethylphenoxy) propyl group, 2- (4-nitro-3-methylphenoxy) ethyl group, 4-nitrophenoxymethyl group, 3-nitrophenoxymethyl group, 2- (2-nitrophenoxy) ethyl group, 2- (4-nitrophenoxy) ethyl group, 1- (3-nitrophenoxy) ethyl group, 2- (2-nitrophenoxy) ethyl group, 2- (4-nitrophenoxy) ethyl group, 2-nitrophenoxy group, 2, 3- (4-nitrophenoxy) propyl, 4- (2-nitrophenoxy) butyl, 5- (3-nitrophenoxy) pentyl, 6- (4-nitrophenoxy) hexyl, 1-dimethyl-2- (2, 4-dinitrophenoxy) ethyl and 2-methyl-3- (2, 4, 6-trinitrophenoxy) propyl.

Examples of the phenyl lower alkanoyl group include phenylalkanoyl groups whose alkanoyl moiety is a straight or branched chain alkanoyl group having 2 to 6 carbon atoms, such as 2-phenylacetyl, 3-phenylpropionyl, 2-phenylpropionyl, 4-phenylbutyryl, 5-phenylpentanoyl, 6-phenylhexanoyl, 2-dimethyl-3-phenylpropionyl and 2-methyl-3-phenylpropionyl.

Examples of the phenyl group which may have 1 to 3 substituents selected from a halogen atom and a lower alkyl group which may have a halogen atom on the phenyl ring include phenyl groups which may have 1 to 3 substituents selected from a halogen atom and a linear or branched alkyl group containing 1 to 6 carbon atoms which may have 1 to 3 halogen atoms on the phenyl ring, such as phenyl, 3, 4-difluorophenyl, 2-fluorophenyl, 3-bromophenyl, 4-iodophenyl, 4-methylphenyl, 2-methylphenyl, 3-methylphenyl, 2-ethylphenyl, 3-ethylphenyl, 4-isopropylphenyl, 3-butylphenyl, 4-pentylphenyl, 4-hexylphenyl, 3, 4-dimethylphenyl, 3, 4-diethylphenyl, 2, 4-dimethylphenyl, 2-ethylphenyl, 4-dimethylphenyl, 2, 5-dimethylphenyl group, 2, 6-dimethylphenyl group, 3, 4, 5-trimethylphenyl group, 2-trifluoromethylphenyl group, 3-trifluoromethylphenyl group, 4-trifluoromethylphenyl group, 2- (bromomethyl) phenyl group, 3- (2-chloroethyl) phenyl group, 4- (2, 3-dichloropropyl) phenyl group, 4- (4-fluorobutyl) phenyl group, 3- (5-chloropentyl) phenyl group, 4- (5-bromohexyl) phenyl group, 4- (5, 6-dibromohexyl) phenyl group, 3, 4-bis (trifluoromethyl) phenyl group, 3, 4-bis (4, 4, 4-trichlorobutyl) phenyl group, 2, 4-bis (3-chloro-2-methylpropyl) phenyl group, 2, 5-bis (3-chloropropyl) phenyl group, 2-trifluoromethylphenyl group, 4-trifluoromethylphenyl group, 3-trifluoromethylphenyl group, 4-bis (4, 4-trichlorobutyl) phenyl group, and the like, 2, 6-bis (2, 2, 2-trifluoroethyl) phenyl group, 3, 4, 5-tris (trifluoromethyl) phenyl group, 4- (2, 2, 2-trichloroethyl) phenyl group, 2-methyl-4-trifluoromethylphenyl group, 3-ethyl-4-trichloromethylphenyl group, 2-chloro-4-trifluoromethylphenyl group, 3-ethyl-4-fluorophenyl group, 3-fluoro-4-trichloromethylphenyl group, 2-methyl-3-trifluoromethyl-4-trifluoromethylphenyl group, 3-fluorophenyl group, 4-fluorophenyl group, 2-bromophenyl group, 4-bromophenyl group, 2-iodophenyl group, 3-iodophenyl group, 2, 3-dibromophenyl group, 2, 4-diiodophenyl group, 2-iodophenyl group, 2, 5-difluorophenyl, 2, 6-dichlorophenyl, 2, 4, 6-trichlorophenyl, 2, 4-difluorophenyl, 3, 5-difluorophenyl, 2, 6-difluorophenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 2, 3-dichlorophenyl, 2, 4-dichlorophenyl, 2, 5-dichlorophenyl, 3, 4-dichlorophenyl, 2, 6-dichlorophenyl, 3, 5-dichlorophenyl, 2, 4, 6-trifluorophenyl and 2, 4-difluorophenyl.

From R²⁰And R²¹、R²²And R²³、R²⁶And R²⁷、R²⁹And R³⁰Or R³²And R³³Examples of the 5-to 7-membered saturated heterocyclic ring which may be formed by bonding each other with or without a nitrogen atom, an oxygen atom or a sulfur atom together with the nitrogen atom bonded thereto include pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl and homopiperazinyl.

Examples of the phenoxy lower alkyl group which may have a lower alkyl group as a substituent on the benzene ring include, in addition to the above-mentioned phenoxy lower alkyl group, a phenoxy alkyl group which may have 1 to 3 straight-chain or branched alkyl groups having 1 to 6 carbon atoms as substituents on the benzene ring and whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms, such as 2-methylphenoxymethyl, 3-methylphenoxymethyl, 4-methylphenoxymethyl, 3, 4-dimethylphenoxymethyl, 2, 3-dimethylphenoxymethyl, 3, 4, 5-trimethylphenoxymethyl, 2- (2-ethylphenoxy) ethyl, 2- (4-methylphenoxy) ethyl, 1- (3-propylphenoxy) ethyl, 3- (4-butylphenoxy) propyl, n-butyl-phenoxy) propyl, n-butyl, 4- (2-pentylphenoxy) butyl, 5- (3-hexylphenoxy) pentyl, 6- (4-methylphenoxy) hexyl, 1-dimethyl-2- (2, 4-dimethylphenoxy) ethyl and 2-methyl-3- (2, 4, 6-trimethylphenoxy) propyl.

More preferred is a compound represented by the general formula (1) or a salt thereof, wherein,

X₁represents a nitrogen atom or a group-CH ═ CH;

R¹represents a group-Z-R⁶，

Z represents a group-N (R)⁸) -B-, group-B-N (R)⁸) -, group-B₀-O-or a group-N (R)^9a)-CO-N-(R^9b)-，

b represents a group-CO-or a lower alkylene group,

B₀represents a lower alkylene group, and is represented by,

R^9arepresents a hydrogen atom or a lower alkyl group,

R^9brepresents a hydrogen atom or a lower alkyl group,

R⁶to represent

[ general formula 58]

The group of (a) or (b),

R⁷represents a halogen atom or a lower alkyl group which may have a halogen atom as a substituent,

m represents an integer of 1 or 2 (when m represents 2, two R⁷May be the same or different); and

R²represents a hydrogen atom, a halogen atom or a lower alkyl group;

y represents a group-O-or a group-N (R)⁵)-，

R⁵Represents a hydrogen atom or a lower alkyl group;

a represents

[ general formula 59]

The group of (a) or (b),

p represents a number of 1 or 2,

R³represents a hydrogen atom, a lower alkoxy group, a halogen atom or a lower alkyl group which may have a halogen atom as a substituent,

R⁴represents a group- (T)₁-N(R¹⁴)R¹⁵，

T represents a group-N (R)¹⁷)-B₃-CO-, group-B₄-CO-or a group-CO-,

R¹⁷represents a hydrogen atom or a lower alkyl group;

B₃represents a lower alkylene group;

B₄Represents a lower alkylene group or a lower alkylene group which may have a hydroxyl group as a substituent;

l represents 0 or 1;

R¹⁴represents a hydrogen atom or an alkyl group which may have a hydroxyl group as a substituent;

R¹⁵represents (36a) an oxalyl group substituted with a piperazinyl group which may have, as a substituent, on the piperazine ring, 1 to 3 groups selected from phenyl lower alkyl groups (which may have, as a substituent, 1 to 3 groups selected from lower alkylenedioxy groups and lower alkoxy groups on the benzene ring) and pyridyl lower alkyl groups,

R¹⁴and R¹⁵A heterocyclic group which together with the nitrogen atom to which it is attached forms a piperidinyl or piperazinyl group,

wherein the heterocyclic ring may be substituted with a lower alkyl group selected from the group consisting of (28) a phenyl group which may be substituted on the benzene ring with a group selected from the group consisting of a lower alkanoyl group, an amino group which may have a lower alkanoyl group as a substituent, a lower alkoxycarbonyl group, a cyano group, a nitro group, a phenyl group, a halogen atom, a lower alkyl group which may have a halogen atom as a substituent, a lower alkoxy group which may have a halogen atom as a substituent, a phenyl lower alkoxy group, a hydroxyl group and a lower alkylenedioxy group, and (49) a group- (B)₁₂CO)t-N(R²⁰)R²¹Or (a)84) Group- (O-B)₁₅)s-CO-N(R²⁶)R²⁷The substituent (a) is substituted with the group (b),

B₁₂represents a lower alkylene group, and is represented by,

t represents a number of 0 or 1,

R²⁰and R²¹A saturated heterocyclic ring formed into a piperidyl group or a piperazinyl group together with a nitrogen atom to which it is bonded, wherein said heterocyclic ring may be substituted with a phenyl lower alkyl group which may have a lower alkylenedioxy group as a substituent on the phenyl ring,

B₁₅Represents a lower alkylene group, and is represented by,

s represents a number of 0 or 1,

R²⁶and R²⁷May be the same or different and each represents a hydrogen atom, a lower alkyl group, a phenyl lower alkyl group or an imidazolyl lower alkyl group, and R²⁶And R²⁷May be linked together directly or through a nitrogen atom, an oxygen atom or a sulfur atom, and may be linked together with the nitrogen atom to which they are linked to form a 5-7 membered saturated heterocyclic ring (wherein the heterocyclic ring may be substituted with 1-3 phenyl lower alkyl groups which may have a lower alkylenedioxy group on the phenyl ring).

For example, a compound represented by the general formula (1) or a salt thereof is more preferable, wherein,

X₁represents a nitrogen atom;

R¹represents a group-Z-R⁶，

Z represents a group-N (R)⁸)-B-，

R⁸Represents a hydrogen atom or a lower alkyl group which may have a lower alkoxy group as a substituent,

b represents a group-CO-,

R⁶to represent

[ general formula 60]

The group of (a) or (b),

R²represents a hydrogen atom;

y represents a group-O-or a group-N (R)⁵)-，

R⁵Represents a hydrogen atom or a lower alkyl group;

a represents

[ general formula 61]

The group of (a) or (b),

p represents a number of 1 or 2,

R⁴Represents a group- (T)₁-N(R¹⁴)R¹⁵，

T represents a group-N (R)¹⁷)-B₃-CO-, group-B₄-CO-or a group-CO-,

R¹⁷represents a hydrogen atom or a lower alkyl group,

B₃represents a lower alkylene group, and is represented by,

B₄represents a lower group which may have a hydroxyl group as a substituentAn alkylene group, and a nitrogen atom,

l represents a number of 0 or 1,

R¹⁴and R¹⁵And a heterocyclic group which forms piperidinyl or piperazinyl together with the nitrogen atom to which it is attached, wherein the heterocyclic group may be substituted on the heterocyclic ring with (28) lower alkyl which may be substituted on the phenyl ring with lower alkylenedioxy substituted phenyl.

Another more preferred example is a compound represented by the general formula (1) or a salt thereof, wherein,

X₁represents a nitrogen atom;

R¹represents a group-Z-R⁶，

Z represents a group-N (R)⁸)-B-，

b represents a group-CO-,

R⁶to represent

[ general formula 62]

The group of (a) or (b),

R²represents a hydrogen atom;

y represents a group-O-or a group-N (R)⁵)-，

R⁵Represents a hydrogen atom or a lower alkyl group;

a represents

[ general formula 63]

The group of (a) or (b),

p represents a number of 1 or 2,

R⁴Represents a group- (T)₁-N(R¹⁴)R¹⁵，

R¹⁷Represents a hydrogen atom or a lower alkyl group,

B₃represents a lower alkylene group, and is represented by,

B₄represents a lower alkylene group which may have a hydroxyl group as a substituent,

l represents a number of 0 s, and,

R¹⁴and R¹⁵A heterocyclic group which together with the nitrogen atom to which it is attached forms a piperidinyl or piperazinyl group, wherein on said heterocyclic ring there may be present a group- (B) selected from (49)₁₂CO)t-N(R²⁰)R²¹And (84) a group- (O-B)₁₅)s-CO-N(R²⁶)R²⁷One of the substituents in (1) is,

B₁₂represents a lower alkylene group, and is represented by,

t represents a number of 0 or 1,

R²⁰and R²¹A heterocyclic group which forms piperidine or piperazine together with the nitrogen atom to which it is attached, wherein one substituent which is a phenyl lower alkyl group which may have a lower alkylenedioxy group as a substituent on the phenyl ring may be present on the heterocyclic ring,

B₁₅represents a lower alkylene group, and is represented by,

s represents a number of 0 or 1,

R²⁶and R²⁷And, together with the nitrogen atom to which they are bonded, are bonded to each other directly or through an oxygen atom or a nitrogen atom to form a 6-membered saturated heterocyclic ring (wherein the heterocyclic ring may be substituted with 1 to 3 phenyl lower alkyl groups which may have a lower alkylenedioxy group as a substituent on the phenyl ring).

The aromatic compound (1) or a salt thereof contained in the STAT3/5 activation inhibitor of the present invention includes stereoisomers, optical isomers, and solvates (hydrates, ethanolates, etc.).

In the aromatic compound (1), a compound having a basic group can easily react with a conventional pharmacologically acceptable acid to form a salt. Examples of such acids include: inorganic acids such as hydrochloric acid, hydrobromic acid, nitric acid, sulfuric acid and phosphoric acid; and organic acids such as methanesulfonic acid, p-toluenesulfonic acid, acetic acid, citric acid, tartaric acid, maleic acid, fumaric acid, malonic acid and lactic acid.

In the aromatic compound (1), a compound having an acidic group can easily react with a conventional pharmacologically acceptable basic compound to form a salt. Examples of such salts include sodium, potassium and calcium salts.

The aromatic compound (1) and salts thereof can be prepared by the same method as disclosed in WO 2006/014012.

Hereinafter, a pharmaceutical preparation containing the aromatic compound (1) and a salt thereof as an active ingredient will be described.

The pharmaceutical preparation is prepared by formulating the aromatic compound (1) and a salt thereof in the dosage form of a pharmaceutical preparation, and more specifically, is prepared using a diluent or an excipient, such as a filler, a swelling agent, a binder, a wetting agent, a disintegrant, a surfactant or a lubricant.

The dosage form of this pharmaceutical preparation can be selected from various dosage forms according to the therapeutic purpose, and the general dosage forms are tablets, pills, powders, liquids, suspensions, emulsions, granules, capsules, suppositories, and injections (liquids, suspensions).

The carrier for forming the tablet may be widely selected from conventionally known carriers. Examples of the carrier include: excipients, such as lactose, sucrose, sodium chloride, glucose, urea, starch, calcium carbonate, kaolin, and microcrystalline cellulose; binders such as water, ethanol, propanol, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethyl cellulose, shellac, methyl cellulose, potassium phosphate and polyvinylpyrrolidone; disintegrants, for example, such as dry starch, sodium arginine (sodium arginate), agar powder, laminarin powder (laminaran powder), sodium bicarbonate, calcium carbonate, polyoxyethylene sorbitan fatty acid esters, sodium lauryl sulfate, glyceryl monostearate, starch and lactose; anti-disintegrators such as sucrose, stearin (stearine), cacao butter and hydrogenated oil; absorbents such as quaternary ammonium bases and sodium lauryl sulfate; humectants, such as glycerin and starch; adsorbents such as starch, lactose, kaolin, bentonite and colloidal silicates; and lubricants such as refined talc, stearate, boric acid powder, and polyethylene glycol.

In addition, the tablets may be coated in a conventional manner as required. Examples of the coated tablet include a sugar-coated tablet, a gelatin-coated tablet, an enteric-coated tablet, a film-coated tablet, or a double or multilayer tablet.

The carrier for forming the pellet may be broadly selected from conventionally known carriers, and examples of the carrier include: excipients such as glucose, lactose, starch, cocoa butter, hydrogenated vegetable oils, kaolin and talc; binders such as gum arabic powder, tragacanth powder, gelatin and ethanol; and disintegrating agents such as laminarin and agar.

The carrier for forming suppositories can be broadly selected from conventionally known carriers, and examples of the carrier include polyethylene glycol, cacao butter, higher alcohols, esters of higher alcohols, gelatin and semisynthetic glycerides.

When a liquid, an emulsion, and a suspension are prepared for use as an injection preparation, it is preferable that it is sterile and is controlled to be isotonic with blood. The diluents used to form these liquid, emulsion and suspension formulations may be broadly selected from conventionally known diluents. Examples of such diluents include water, ethanol, propylene glycol, ethoxylated isostearyl alcohol, polyoxylated isostearyl alcohol, and polyoxyethylene sorbitan fatty acid alcohol esters. In this case, the pharmaceutical preparation may contain a sufficient amount of sodium chloride, glucose or glycerol to prepare an isotonic solution. Likewise, conventional solubilizers, buffers, analgesics, etc. may be contained, and, if necessary, colorants, preservatives, flavors, sweeteners, etc., or other agents.

Although the amount of the aromatic compound (1) or a salt thereof contained in the pharmaceutical preparation is not particularly limited and may be appropriately selected within a wide range of compounds. However, it is preferable that the amount of the aromatic compound (1) or a salt thereof contained in the pharmaceutical preparation is 1 to 70 wt%.

The method of administration of the pharmaceutical preparation according to the present invention is not particularly limited. The method of administration of the pharmaceutical preparation is determined according to the dosage form of the pharmaceutical preparation, the age, sex, severity of disease and other conditions of the patient. For example, tablets, pills, liquids, suspensions, emulsions, granules and capsules are administered orally. The injectable preparation is administered alone intravenously or by mixing with a conventional rehydration solution such as a glucose solution or an amino acid solution, or, if necessary, alone intramuscularly, intracutaneously, subcutaneously or intraperitoneally. The suppositories are administered into the rectum.

The dosage of the above pharmaceutical preparation can be appropriately selected depending on the administration, the age, sex, severity of disease and other conditions of the patient. Usually, the drug is administered once or several times daily at 0.001 to 100mg per kg of body weight per day, preferably 0.001 to 50mg per kg of body weight per day.

Since the above-mentioned dose may vary depending on various conditions, the dose may be less than the lower limit of the above-mentioned range or greater than the upper limit of the above-mentioned range.

The aromatic compound (1) or a salt thereof in the present invention has STAT3/5 activation inhibitory activity and is useful as a STAT3/5 activation inhibitor.

The aromatic compound (1) or a salt thereof has STAT3 activation inhibitory activity and is therefore useful as a medical drug for preventing or treating autoimmune diseases, diabetes, infections, central nervous diseases, cancer-related diseases, or psoriasis.

Examples of autoimmune diseases include autoimmune cachexia (e.g., hemolytic anemia, aplastic anemia, and idiopathic thrombocytopenia), rheumatism, systemic lupus erythematosus, polychondritis, Wegener's granulomatosis, dermatomyositis, chronic active hepatitis, severe muscle weakness, Stevens-Johnson syndrome, idiopathic toxic diarrhea (idiophathic spele), inflammatory bowel disease (e.g., ulcerative colitis and crohn's disease), endocrine ocular disease, toxic diffuse goiter (Graves ' disease), sarcoidosis (sarcoidosis), multiple sclerosis, primary biliary cirrhosis, juvenile diabetes mellitus (type I diabetes), uveitis (anterior and posterior uveitis), vernal keratoconjunctivitis, psoriatic arthritis, nephropathia (with or without glomerular symptoms of nephropathy, such as idiopathic nephrotic syndrome or minimal change nephropathy).

For central nervous diseases, alzheimer's disease may be mentioned.

For cancer-related diseases, cachexia may be mentioned.

As the infection, there can be mentioned infection with Hepatitis C Virus (HCV) and infection with Kaposi's sarcoma-associated herpes virus (KSHV).

In addition, the compound of the present invention has STAT5 activation inhibitory activity and is useful as a STAT5 activation inhibitor, particularly as a prophylactic or therapeutic agent for the above-mentioned autoimmune diseases, allergy, inflammation, hyperprolactinemia, and the like.

In the present invention, the aromatic compound (1) or a salt thereof may be used in combination with other drugs such as: other STAT3 activation inhibitors, STAT5 activation inhibitors, immunosuppressive agents, anti-inflammatory agents, therapeutic agents for diabetes, therapeutic agents for infectious diseases, therapeutic agents for central nervous diseases, therapeutic agents for cancer-related diseases, therapeutic agents for psoriasis, antitumor agents, and fibrosis inhibitors.

The patents, patent applications, and literature cited in this disclosure are incorporated herein by reference.

Detailed Description

[ example 1]

Testing the Effect of Compounds on the amount of STAT3 activated in the nucleus of Hep G2 cells after stimulation with IL-6

1) Culturing

After Hep G2 cells were washed twice with PBS (-), washed once with trypsin/EDTA solution and detached using trypsin/EDTA solution. The cells were centrifuged and suspended in a medium supplemented with antibiotics (MEM medium (10% FBS + antibiotics (100U/mL penicillin + 100. mu.g/mL streptomycin)), after counting the number of cells, the cells were cultured at 1.2X 10 ⁵Cells/1 mL per well were seeded in 12-well plates.

Two days after seeding the cells, the medium was replaced with 1mL of antibiotic-free medium (MEM medium (10% FBS)).

2) Adding test compound

Two days after medium replacement, test compounds were added to give concentrations of 0, 1, 10 and 100 nM.

Three hours after the test compound was added, IL-6 (No. KTS102S, manufactured by Kamakura Techno Science Inc.) was added to a final concentration of 0 or 500 ng/mL.

5 minutes after the addition of IL-6, Extraction was performed using a Nuclear Extraction Kit (No. 40410, manufactured by Active Motif Inc.).

3) Extraction of nuclear components

The cell supernatant was removed by aspiration. The cells were washed with 1mL of ice-cold PBS containing a phosphatase inhibitor (hereinafter, PBS/phosphatase inhibitor) and the supernatant of the cells was removed by aspiration.

Cells were collected in 0.6mL of ice-cold PBS/phosphatase inhibitor using a cell scraper and dispensed into ice-cold 1.5mL microtubes.

After the microtube was centrifuged at 400 Xg for 5 minutes at 4 ℃, the supernatant was removed.

The cells were redispersed in 0.2mL hypotonic buffer by pipetting up and down several times and placed on ice for 15 minutes.

To this suspension was added 10. mu.L of detergent and vortexed for 10 seconds. After centrifugation at 20,400 Xg for 30 seconds at 4 ℃ the supernatant was removed.

To the resulting cells, 50. mu.L of complete lysis buffer was added. The suspension was aspirated with a pipette, vortexed for 10 seconds, and shaken on ice for 30 minutes.

After vortexing for 30 seconds, the suspension was centrifuged at 20,400 Xg for 10 minutes at 4 ℃.

The supernatant was divided into ice-cold 1.5mL microtubes and stored at-80 ℃.

4) Using a TransAM STAT3 Kit (no: 45196, manufactured by Active motif inc).

To each well of the ELISA plate was added 30. mu.L of complete binding buffer and 20. mu.L of sample (extracted from the nuclei).

Positive control: mu.l of HepG2 cell nucleus extract (2.5mg/mL) was diluted with 40. mu.L of complete lysis buffer (10. mu.g/20. mu.L). Dilutions of 5, 2.5, 1.25, 0.625 and 0.313. mu.g/20. mu.L were prepared by serial half-dilutions and 20. mu.L was added to each well.

Blank wells: add 20. mu.L of complete lysis buffer.

After sealing the plate, the plate was gently shaken at room temperature for 1 hour, and then washed three times with 200. mu.L of wash buffer.

100 μ L of STAT3 antibody was added and the plate was sealed. After that, the plate was gently shaken at room temperature. After 1 hour, the plate was washed three times with 200 μ L of wash buffer. After washing, 100 μ L of HRP-bound antibody was added. After sealing the plate, gently shaking for 1 hour at room temperature, it was then washed four times with 200. mu.L of wash buffer.

Then, 100. mu.L of developing solution returned to room temperature was added, and the plate was incubated for 2 to 10 minutes in the dark. After the color development was confirmed, 100. mu.L of stop solution was added and the absorbance was measured at 450nm and 630nm within 5 minutes.

5) The results for the test compounds listed in table 1 below are shown in table 2.

[ Table 1]

Test compounds

^*: () The values in parentheses are the numbers of the examples in WO 2006/014012.

[ Table 2]

Results

Test Compound number	IC₅₀(nM)
		1	＜150
2	＜150
		3	＜150
4	＜150
		5	＜150
6	＜150
		7	＜150
8	＜150

[ example 2]

The effect of test compounds on inhibition of STAT3 phosphorylation.

(1) Cells

Cell seeding

After the Hep G2 cells were washed twice with PBS (-), they were washed with and removed with trypsin/EDTA solution and further removed using trypsin/EDTA solution. The cells were centrifuged and suspended in a medium supplemented with antibiotics (MEM medium (10% FBS + antibiotics (100U/mL penicillin + 100. mu.g/mL streptomycin)), after counting the number of cells, the cells were cultured at 2.4X 10⁵The ratio of cells/2 mL per well was plated on 6-well plates.

After two days, the antibiotic-added medium was replaced with a medium to which no antibiotic was added (MEM medium (10% FBS)).

Treatment of cells with a medical drug

Three hours after the test compound was added, IL-6 (No. KTS102S, manufactured by Kamakura Techno Science Inc.) was added to a concentration of 100 ng/mL.

Recovery of cells

Five minutes after the addition of IL-6, the cells were washed twice with cooled PBS (-) and scraped from the plate with a spatula. Cells were collected into 1.5mL microtubes using PBS (-). Cells collected in 1.5mL microtubes were centrifuged and the supernatant removed. Cells collected in 1.5mL microtubes were refrigerated in a cryorefrigerator until use.

Cracking treatment

RIPA buffer was added to the frozen cells. The frozen cells were suspended using a 1mL syringe with a 26 Gx 1/2 syringe needle, and the suspension was allowed to stand in ice water for 30-60 minutes. The cell suspension was centrifuged and the supernatant (cell lysate) was transferred to a new tube. The cell lysate collected in the test tube is refrigerated in a cryorefrigerator until use.

Measurement of protein concentration

The amount of protein in each cell lysate was measured according to the method attached to the BCA protein assay kit (BCA proteinassay reagent set).

(2) Western blot analysis

PAGE (electrophoresis)

After the amount of protein in each cell lysate was set to the same value, denaturation treatment was performed under reducing conditions. After the sample and the molecular marker are added to the polyacrylamide gel, electrophoresis is performed.

Print

After the electrophoresis is completed, the gel is equilibrated with the solution to be used in the transfer.

The protein developed on the polyacrylamide gel was transferred onto a PVDF (polyvinylidene fluoride) membrane using a semidry transfer device.

Sealing/washing

After washing the PVDF membrane, it was soaked in a blocking solution (5% BSA) for blocking.

Primary antibody (phospho-STAT 3(Ser 727) antibody or phospho-STAT 3(Tyr 705) antibody)

The blocked PVDF membrane is reacted with a primary antibody.

Secondary antibody (anti-rabbit IgG HRP labeled antibody)/wash

After washing, the PVDF membrane was reacted with the HRP-labeled antibody.

Color development detection with ECL

After washing the PVDF membrane, color development was performed using ECL Western blot detection reagent and fluorescence was detected with LAS-3000.

The effect of test compounds on inhibition of STAT3 phosphorylation was measured according to the methods described above.

[ example 3]

Effect of test Compounds on prolactin-induced STAT5 activation in 22Rv1 cells

1) Culturing

Cryopreserved 22Rv1 cells were tested after at least two subcultures. After culturing to near confluence, the cells were washed with D-PBS (-). Then, they were detached with trypsin/EDTA solution and suspended in a medium (RPMI-1640 medium (10% FBS + antibiotics (100U/mL penicillin + 100. mu.g/mL streptomycin)). the cell suspension was centrifuged at 150 Xg for 5 minutes at 20 to 25 ℃, the supernatant was removed and the pellet was resuspended in the medium ⁵cells/mL, at 2X 10 per well⁵Ratio of cells/mL cells were seeded in 12-well plates. In CO₂Incubator (5% CO)₂Cells were cultured at 37 ℃.

2) Adding test compound

Two days after inoculation, test compounds were added to give concentrations of 0 and 1000 nM.

3 hours after the test compound was added, recombinant human prolactin (rhPRL, R & D systems Inc.) was added to give a concentration of 0 or 250 ng/mL.

3) Extraction of cytoplasmic fraction

Extraction was performed 15 minutes after the addition of prolactin using a nuclear extraction kit (No. 40410, manufactured by activemotif inc.). At 15 minutes after the addition of prolactin, the supernatant was removed and prolactin stimulation was immediately terminated by the addition of 1ml of ice-cold PBS/phosphatase inhibitor. After aspiration of 1mL of ice-cold PBS/phosphatase inhibitor, 0.6mL of ice-cold PBS/phosphatase inhibitor was added and centrifuged at 200 Xg for 5 minutes at 4 ℃.

After removal of the supernatant, 0.2mL hypotonic buffer was added and suspended. After the suspension was left on ice for 15 minutes, 10. mu.L of detergent was added. After the solution was further stirred, it was centrifuged at 14,000 Xg for 1 minute at 4 ℃. The resulting supernatant (cytoplasmic fraction) was divided into three ice-cold 96-well plates and stored in a freezer at-80 ℃.

4) Measurement of activated STAT5

Using TransAM^TMSTAT family kit attached reagents were measured. More specifically, to the TransAM^TMmu.L of complete binding buffer was added to each well of the ELISA plate of STAT family kit, followed by 20. mu.L of cytoplasmic fraction. For the samples of the calibration curve, 12. mu.L TransAM was diluted with 48. mu.L complete lysis buffer^TMA reference sample of the nuclear component attached to STAT family kit (Nb2 nuclear component (prolactin-stimulated, 2.5. mu.g/. mu.L)) (to 10. mu.g/. mu.L) and further diluted in half and in series to prepare 5, 2.5, 1.25, 0.625, 0.313 and 0.156. mu.g/. mu.L dilutions, 20. mu.l each dilution was added to the wells. For the blank, 20. mu.L of complete lysis buffer was added. After the addition of the sample, the plate was sealed and shaken gently for 1 hour at room temperature. The plate was then washed three times with 200 μ L of wash buffer. Next, 100 μ L of STAT5B antibody was added, sealed and cultured at room temperature without stirring. After 1 hour, the plate was washed three times with 200 μ L of wash buffer. 100 μ L of horseradish peroxidase (HRP) -conjugated antibody was added, sealed and incubated at room temperature without stirring. After 1 hour, the plate was washed four times with 200. mu.L of wash buffer and 100. mu.L of developing solution was added. The plate was incubated in the dark for 2-10 minutes. After the color development was confirmed, 100. mu.L of stop solution was added. Immediately thereafter, the absorbance was measured at 450nm (measurement wavelength) and 630nm (reference wavelength) using a plate reader.

The amount of phosphorylated STAT5B dimer was estimated from the calibration curve. Further, the ratio (T/C%) of the amount of phosphorylated STAT5B dimer in the presence and absence of each medical drug was calculated. The results for the test compounds listed in table 1 are shown in table 3.

[ Table 3]

Test Compound number		T/C％
			Target (DMSO)	0	100
1	1000nM	＜30
			2	1000nM	＜30
3	1000nM	＜30
			4	1000nM	＜30
5	1000nM	＜30
			6	1000nM	＜30
7	1000nM	＜30
			8	1000nM	＜30

[ example 4]

Effect of test Compounds on models of sodium anhydroglucarate (DSS) -induced colitis

1. Induction of colitis by DSS

After the female mice C57BL/6J Jms Slc were preliminarily bred for 1 week, the mice were divided into groups according to their Body Weights (BW) on the dividing day and according to the stratified random sampling method.

DSS (batch: 4556J, MP Biomedicals) was dissolved in Otsuka distilled water to prepare a 4% DSS solution. Mice were allowed to drink the 4% DSS solution freely for 7 days from the day following (the second day) the start of the administration to induce colitis.

2. Administration of test Compounds and solvents

Each of the administration solutions was orally administered at a dose of 10mL/kg per day, based on the body weight before (day 1) administration of the DSS solution and the most recent body weight after administration of the DSS solution.

The dose of test compound was 300 mg/kg.

The dosing solution was prepared by suspending the test compound in a 5% gum arabic solution to give a concentration of 30mg/mL of the test compound.

3. Autopsy

Necropsy was performed on day 8.

4. Blood collection

After blood was collected from the posterior abdominal vena cava under ether anesthesia, it was immediately transferred to BDMicrotainer(Nippon Becton, Dickinson and Company), mixing was performed by inverting the Micro-Tina and standing in ice. The Micro-Tina was centrifuged at 2,150 xg for 20 minutes at 4 ℃ using a refrigerated centrifuge (HITACHI CF9RX, T3S51 rotor) to obtain heparin plasma. The plasma was refrigerated in portions in a freezer (-80 ℃) until measured.

5. Organ collection

After mice were killed by exsanguination by cutting the posterior abdominal vena cava under ether anesthesia, the spleen was excised. The weight of the spleen was measured with an electronic force scale. And immediately the large intestine was removed for measurement of intestinal length and evaluation of intestinal shortening.

6. Measurement item

Body weight

Body weights were measured on day 1 (group day), 3, 5, 7, and 8 (necropsy day) electronic force scales.

Body weight change was calculated from body weights on day 1 (group day) and day 8 (necropsy day).

Spleen weight

The weight of the spleen was measured with an electronic force scale.

In addition, from the measurement results of the spleen weight, the spleen weight ratio (T/C%) and the inhibition rate of increase in spleen weight (IR%) relative to the average spleen weight of the control group were calculated.

Length of intestinal tract

The length of the large intestine was measured with a graduated scale.

In addition, from the measurement results of the large intestine length, the intestinal length ratio (T/C%) and the intestinal shortening inhibition ratio (IR%) were calculated with respect to the average intestinal length of the control group.

The results of the test compounds are shown in table 4.

[ Table 4]

Test Compound number	Inhibition of spleen weight increase IR (%)
		9 (example 305 of WO 2006/014012)	＞40
10 (example 1105 of WO 2006/014012)	＞40
		11 (example 1503 of WO 2006/014012)	＞40

Claims

1. Use of an aromatic compound represented by the following general formula or a salt thereof for the preparation of a STAT3/5 activation inhibitor:

[ general formula 1]

Wherein, X₁Represents a nitrogen atom;

R¹represents a group-Z-R⁶，

Z represents a groupgroup-N (R)⁸) -B-or a group-B-N (R)⁸)-，

R⁸Represents a hydrogen atom, a straight chain or branched alkyl group having 1 to 6 carbon atoms which may have a straight chain or branched alkoxy group having 1 to 6 carbon atoms as a substituent,

b represents a group-CO-or a straight-chain or branched alkylene group having 1 to 6 carbon atoms,

R⁶to represent

[ general formula 5]

The group of (a) or (b),

R⁷represents a straight-chain or branched alkyl group having 1 to 6 carbon atoms which may have a halogen atom as a substituent,

m represents an integer of 1 to 5, wherein when m represents 2 to 5, 2 to 5R⁷May be the same or different; and

R²represents a hydrogen atom, a halogen atom or a straight chain or branched alkyl group having 1 to 6 carbon atoms;

y represents a group-O-or a group-N (R)⁵)-，

R⁵Represents a hydrogen atom or a straight chain or branched alkyl group having 1 to 6 carbon atoms;

a represents

[ general formula 6]

Group of (A) or

[ general formula 7]

The group of (a) or (b),

p represents a number of 1 or 2,

R³represents a hydrogen atom, a halogen atom, or may have a halogenA straight chain or branched alkyl group having 1 to 6 carbon atoms as a substituent,

R⁴represents a group- (T)₁-N(R¹⁴)R¹⁵，

T represents a group-N (R) ¹⁷)-B₃-CO-, group-B₄-CO-or a group-CO-,

wherein R is¹⁷Represents a hydrogen atom, a straight chain or branched alkyl group having 1 to 6 carbon atoms, a straight chain or branched alkenyl group having 2 to 6 carbon atoms,

B₃represents a straight-chain or branched alkylene group having 1 to 6 carbon atoms,

B₄represents a linear or branched alkylene group having 2 to 6 carbon atoms or a linear or branched alkylene group having 1 to 6 carbon atoms which may have a hydroxyl group as a substituent,

1 represents a number of 0 or 1,

R¹⁴represents a hydrogen atom or a straight chain or branched alkyl group having 1 to 6 carbon atoms which may have a hydroxyl group as a substituent,

R¹⁵represents (2) a hydroxyl-substituted alkyl group having 1 to 6 carbon atoms; (3) a cycloalkyl group having 3 to 16 carbon atoms which may have a group selected from a hydroxyl group and a linear or branched alkyl group having 1 to 6 carbon atoms as a substituent; (4) a phenoxyalkyl group, the alkyl moiety of which is a straight-chain or branched alkyl group having 1 to 6 carbon atoms; (5) phenyl which may be substituted on the phenyl ring by 1 to 3 groups selected from straight or branched chain alkyl groups having 1 to 6 carbon atoms; a straight-chain or branched alkoxy group having 2 to 6 carbon atoms which may have a halogen atom as a substituent; a halogen atom; an aminoalkoxy group which may have a linear or branched alkyl group having 1 to 6 carbon atoms as a substituent, wherein the aminoalkoxy group is a linear or branched alkoxy group having 2 to 6 carbon atoms substituted with an amino group; a straight-chain or branched alkyl group having 1 to 6 carbon atoms and having 1 to 3 hydroxyl groups as substituents; phenylalkyl, wherein the alkyl part of the phenylalkyl is straight-chain or branched alkyl with 1-6 carbon atoms; a straight or branched chain alkynyl group having 2 to 6 carbon atoms; an amino group which may have an alkylsulfonyl group whose alkyl moiety is a group having A straight chain or branched chain alkyl group of 1 to 6 carbon atoms; an alkylthio group, the alkyl portion of which is a straight-chain or branched alkyl group having 1 to 6 carbon atoms; a cycloalkyl group having 3 to 16 carbon atoms; a phenylthio group; an adamantyl group; an anilino group which may have a halogen atom as a substituent on the benzene ring; an alkoxycarbonyl group whose alkoxy moiety is a straight-chain or branched alkoxy group having 1 to 6 carbon atoms; a piperazinyl group which may have a straight chain or branched alkyl group having 1 to 6 carbon atoms as a substituent on the piperazine ring; a pyrrolidinyl group which may have an oxy group as a substituent on the pyrrolidine ring; a straight-chain or branched alkanoylamino group having 2 to 6 carbon atoms, having 1 to 3 halogen atoms as a substituent; a cyano group; and a phenoxy group; or (6) phenoxy;

R¹⁴and R¹⁵May be linked to each other directly or through a nitrogen atom, an oxygen atom or a sulfur atom, and together with the nitrogen atom to which they are linked, to form a 5-to 10-membered saturated or unsaturated heterocyclic ring, wherein, on the heterocyclic ring, 1 to 3 substituents selected from the following groups may be present: (28) a phenyl-substituted alkyl group having 1 to 2 phenyl groups and may have a pyridyl group on the alkyl group, the alkyl group portion of which has 1 to 6 carbon atoms, the phenyl group may be substituted on the phenyl ring by 1 to 3 groups selected from the group consisting of: a straight-chain or branched alkanoyl group having 1 to 6 carbon atoms; an amino group which may have a straight-chain or branched alkanoyl group having 1 to 6 carbon atoms as a substituent; a linear or branched alkoxycarbonyl group having 1 to 6 carbon atoms; a cyano group; a nitro group; a phenyl group; a halogen atom; a straight-chain or branched alkyl group having 1 to 6 carbon atoms which may have a halogen atom as a substituent; a straight-chain or branched alkoxy group having 1 to 6 carbon atoms which may have a halogen atom as a substituent; a phenylalkoxy group whose alkoxy moiety is a straight-chain or branched alkoxy group having 1 to 6 carbon atoms; a hydroxyl group; and a straight-chain or branched alkylene group having 1 to 4 carbon atoms, or (49) a group- (B) ₁₂CO)t–N(R²⁰)R²¹，

B₁₂Represents a straight-chain or branched alkylene group having 1 to 6 carbon atoms,

t represents a number of 0 or 1,

R²⁰and R²¹Directly or via a nitrogen atom,Oxygen or sulfur atoms are linked to each other and together with the nitrogen atom to which they are linked to form a 5-7 membered saturated heterocyclic ring, wherein, on the heterocyclic ring, 1-3 substituents may be present, said substituents being selected from the group consisting of: a straight chain or branched alkyl group having 1 to 6 carbon atoms; a phenyl group which may have 1 to 3 groups selected from a halogen atom and a straight-chain or branched alkyl group having 1 to 6 carbon atoms which may have a halogen atom as a substituent on a benzene ring; and a phenylalkyl group having an alkylenedioxy group which may have a straight-chain or branched alkylene group having 1 to 4 carbon atoms on the benzene ring as a substituent, the alkyl moiety of which is a straight-chain or branched alkyl group having 1 to 6 carbon atoms,

provided that the above-mentioned compound or a salt thereof satisfies the following requirements (iv):

(iv)X₁represents a nitrogen atom, and l represents 0, or X₁Represents a nitrogen atom, l represents 1, and T represents-CO-, then R¹⁵Is not the group (5).

2. The use according to claim 1, wherein the alkylenedioxy group as 1 to 3 groups substituted on the benzene ring of the (28) phenyl-substituted alkyl group is selected from the group consisting of a methylenedioxy group, an ethylenedioxy group and a trimethylenedioxy group.

3. The use according to claim 1, wherein the alkylenedioxy group on the phenyl ring of the phenylalkyl group is selected from the group consisting of a methylenedioxy group, an ethylenedioxy group and a trimethylenedioxy group.

4. The use according to claim 1, wherein the aromatic compound or a salt thereof is a compound selected from the group consisting of compounds represented by the following general formulae (1-1) to (1-2):

5. the use according to claim 1, wherein the aromatic compound or a salt thereof is a compound selected from the group consisting of compounds represented by the following general formulae (1-8) to (1-9):

6. use according to any one of claims 1 to 5, wherein Y is a group-O-.

7. Use according to any one of claims 1 to 5, wherein Y is a group-N (R)⁵)-。

8. Use according to any one of claims 1 to 5, wherein A is a group:

9. the use according to any one of claims 1 to 5, wherein the aromatic compound or a salt thereof is represented by the general formula (1), wherein R⁴Represents a group- (T)_l-N(R¹⁴)R¹⁵，T、R¹⁴And R¹⁵As defined above, and l represents 0.

10. Use according to any one of claims 1 to 5, wherein R⁴Is a group- (T)_l-N(R¹⁴)R¹⁵And l is 1.

11. The composition of any one of claims 1 to 5 Wherein R is⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a group-N (R)¹⁷)-B₃-CO-。

12. Use according to any one of claims 1 to 5, wherein R⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a radical-B₄-CO-。

13. Use according to any one of claims 1 to 5, wherein R⁴Is a group- (T)_l-N(R¹⁴)R¹⁵L is 1, and T is a group-CO-.

14. The use according to claim 1, wherein the aromatic compound or a salt thereof is a compound selected from the group consisting of compounds represented by the general formulae (1-1), (1-2), (1-8), (1-9):

wherein A is a group:

R⁴is a group- (T)_l-N(R¹⁴)R¹⁵。

15. Use according to claim 14, wherein l is 1 and T is a group-N (R)¹⁷)-B₃-CO-。

16. Use according to claim 14, wherein l is 1 and T is a group-B₄-CO-。

17. Use according to claim 14, wherein l is 1 and T is a group-CO-.

18. Use according to claim 14, wherein i is 0.

19. Use of an aromatic compound or a salt thereof in the preparation of a STAT3/5 activation inhibitor, the aromatic compound being selected from the group consisting of:

n- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] ethylamino } -2-methoxyphenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide,

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] ethylamino } phenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide,

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] ethylamino } -2-fluorophenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide,

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] methylamino } -2-fluorophenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide,

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] methylamino } -2-methoxyphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide,

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] ethylamino } -2-methoxyphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide,

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] ethylamino } -2-methylphenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide,

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] methylamino } -2-methylphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide,

N- (6- {4- [3- (4-piperonylpiperazin-1-yl) -3-oxopropyl ] phenoxy } pyridin-3-yl) -3, 4-dichlorobenzenesulfonamide,

N- [6- (4- {4- [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] piperazin-1-yl } phenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide,

N- [6- (4- {4- [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } phenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide,

N- {6- [ (4- {4- [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } phenyl) methylamino ] pyridin-3-yl } -4-trifluoromethylbenzamide,

N- [6- (4- {4- [2- (4-benzylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } -2-methylphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide,

N- [6- (4- {4- [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } -2-methylphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide,

N- [6- (4- {4- [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } -2-methylphenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide,

N- {6- [4- (4-benzylpiperazine-1-carbonyl) phenoxy ] pyridin-3-yl } -4-trifluoromethylbenzamide,

N- {6- [4- (4-benzylpiperazine-1-carbonyl) phenoxy ] pyridin-3-yl } -3, 4-dichlorobenzamide,

N- [6- ({4- [3- (4-piperonylpiperazin-1-yl) -3-oxopropyl ] phenyl } methylamino) pyridin-3-yl ] -4-trifluoromethylbenzamide,

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] ethylamino } -2-fluorophenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide,

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] methylamino } -2-fluorophenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide,

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] methylamino } -2-methoxyphenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide,

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] methylamino } phenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide,

1- (6- {4- [3- (4-Piperazinylpiperazin-1-yl) -3-oxopropyl ] phenoxy } pyridin-3-yl) -3- (3, 4-dichlorophenyl) -1-ethylurea,

N- (6- {4- [3- (4-piperonylpiperazin-1-yl) -3-oxopropyl ] phenoxy } pyridin-3-yl) -4-trifluoromethylbenzamide,

N- [6- (4- { [2- (4-benzylpiperazin-1-yl) -2-oxoethyl ] methylamino } -2-methylphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide,

N- [6- (4- {4- [2- (4-benzylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } phenoxy) pyridin-3-yl ] -3, 4-dichlorobenzamide,

N- (6- {4- [3- (4-piperonylpiperazine-1-carbonyl) piperidin-1-yl ] phenoxy } pyridin-3-yl) -3, 4-dichlorobenzamide,

N- [6- (4- {4- [2- (4-benzylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } phenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide,

N- {6- [ (4- {4- [2- (4-benzylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } phenyl) methylamino ] pyridin-3-yl } -4-trifluoromethylbenzamide,

N- (6- {4- [ (2- {4- [4- (4-fluorobenzoyl) phenyl ] piperazin-1-yl } -2-oxoethyl) methylamino ] -2-methoxyphenoxy } pyridin-3-yl) -4-trifluoromethylbenzamide,

2- (4-Piperazino-1-yl) -N- { 3-methyl-4- [5- (4-trifluoromethylphenoxymethyl) pyridin-2-yloxy ] phenyl } -2-oxoacetamide,

N- [6- (4- { [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] methylamino } -2-methylphenoxy) pyridin-3-yl ] -2-fluoro-4-trifluoromethylbenzamide,

N- [6- (4- {4- [2- (4-piperonylpiperazin-1-yl) -2-oxoethyl ] piperidin-1-yl } -2-methoxyphenoxy) pyridin-3-yl ] -4-trifluoromethylbenzamide and

4- (3- { 3-methyl-4- [5- (4-trifluoromethylbenzoylamino) pyridin-2-yloxy ] phenyl } -2-oxohexahydropyrimidin-1-yl) benzoic acid ethyl ester.

20. Use according to claim 1, wherein, in the aromatic compound, R¹⁴And R¹⁵Are linked to each other directly or through a nitrogen atom and form a 6-membered saturated heterocyclic group together with the nitrogen atom to which they are linked, and wherein a phenyl-substituted alkyl group whose alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms is present as a substituent on the saturated heterocyclic group And (b) a substituent, wherein the phenyl-substituted alkyl group can be substituted on a benzene ring by 1-2 groups selected from the following groups as substituents: a straight-chain or branched alkanoyl group having 1 to 6 carbon atoms; an amino group which may have a straight-chain or branched alkanoyl group having 1 to 6 carbon atoms as a substituent; an alkoxycarbonyl group whose alkoxy moiety is a straight-chain or branched alkoxy group having 1 to 6 carbon atoms; a cyano group; a nitro group; a phenyl group; a halogen atom; a straight-chain or branched alkyl group having 1 to 6 carbon atoms which may have a halogen atom as a substituent; a straight-chain or branched alkoxy group having 1 to 6 carbon atoms which may have a halogen atom as a substituent; a phenylalkoxy group whose alkoxy moiety is a straight-chain or branched alkoxy group having 1 to 6 carbon atoms; a hydroxyl group; and an alkylenedioxy group having a straight-chain or branched alkylene group of 1 to 4 carbon atoms.

21. The use according to claim 20, wherein the alkylenedioxy group on the benzene ring of the phenyl-substituted alkyl group is selected from the group consisting of methylenedioxy, ethylenedioxy and trimethylenedioxy.

22. The use according to claim 20, wherein an alkyl group substituted with a phenyl group substituted with an alkylenedioxy group is present as a substituent on the piperazinyl group which is a saturated heterocyclic group.

23. Use according to any one of claims 20 to 22, wherein X₁Is a nitrogen atom and Y is an oxygen atom.

24. Use of the aromatic compound or a salt thereof described in claim 1 for the preparation of a medicament for preventing or treating a symptom or disease associated with STAT3 activation.

25. The use according to claim 24, wherein the symptom or disease associated with STAT3 activation is an autoimmune disease, diabetes, infection, central nervous disease, cancer-related disease, or psoriasis.

26. Use of the aromatic compound or a salt thereof described in claim 1 for the preparation of a medicament for preventing or treating a symptom or disease associated with STAT5 activation.

27. The use according to claim 26, wherein the symptom or disease associated with STAT5 activation is an autoimmune disease, allergy, or hyperprolactinemia.