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HK1130049A1 - 三环类化合物及其药物用途 - Google Patents

三环类化合物及其药物用途 Download PDF

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Publication number
HK1130049A1
HK1130049A1 HK09107988.0A HK09107988A HK1130049A1 HK 1130049 A1 HK1130049 A1 HK 1130049A1 HK 09107988 A HK09107988 A HK 09107988A HK 1130049 A1 HK1130049 A1 HK 1130049A1
Authority
HK
Hong Kong
Prior art keywords
compound
ethyl
dihydro
indeno
reaction
Prior art date
Application number
HK09107988.0A
Other languages
German (de)
English (en)
French (fr)
Other versions
HK1130049B (zh
Inventor
Osamu Uchikawa
Tatsuki Koike
Yasutaka Hoashi
Takafumi Takai
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of HK1130049A1 publication Critical patent/HK1130049A1/zh
Publication of HK1130049B publication Critical patent/HK1130049B/zh

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/423Oxazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/428Thiazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK09107988.0A 2006-06-19 2007-06-18 三环类化合物及其药物用途 HK1130049B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006168518 2006-06-19
JP2006168518 2006-06-19
PCT/JP2007/062645 WO2007148808A1 (en) 2006-06-19 2007-06-18 Tricyclic compound and pharmaceutical use thereof

Publications (2)

Publication Number Publication Date
HK1130049A1 true HK1130049A1 (zh) 2009-12-18
HK1130049B HK1130049B (zh) 2015-03-06

Family

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Also Published As

Publication number Publication date
EP2029561B1 (en) 2014-08-13
CL2007001779A1 (es) 2008-01-04
BRPI0713743C1 (pt) 2021-05-25
BRPI0713743B8 (pt) 2020-05-19
US20130079374A1 (en) 2013-03-28
KR101442274B1 (ko) 2014-09-22
US8236837B2 (en) 2012-08-07
CA2655753A1 (en) 2007-12-27
ME00582A (en) 2011-12-20
US8030337B2 (en) 2011-10-04
CR10524A (es) 2009-01-27
NZ574037A (en) 2011-10-28
JP2009541202A (ja) 2009-11-26
ZA200900151B (en) 2010-03-31
CN101506181B (zh) 2011-12-07
UA99104C2 (uk) 2012-07-25
RU2009101299A (ru) 2010-07-27
US8895591B2 (en) 2014-11-25
MA30523B1 (fr) 2009-06-01
TW200815376A (en) 2008-04-01
CA2655753C (en) 2015-08-04
NO341739B1 (no) 2018-01-15
KR20090023701A (ko) 2009-03-05
US20110190361A1 (en) 2011-08-04
SI2029561T1 (sl) 2014-11-28
RU2456278C2 (ru) 2012-07-20
MY158069A (en) 2016-08-30
US20110196003A1 (en) 2011-08-11
US20140011849A1 (en) 2014-01-09
TWI402261B (zh) 2013-07-21
WO2007148808A1 (en) 2007-12-27
PE20080941A1 (es) 2008-09-04
JP5222737B2 (ja) 2013-06-26
PL2029561T3 (pl) 2015-03-31
CO6150175A2 (es) 2010-04-20
RS53616B1 (sr) 2015-04-30
PT2029561E (pt) 2014-11-12
ME01998B (me) 2015-05-20
AU2007261953A1 (en) 2007-12-27
US8552037B2 (en) 2013-10-08
HRP20141046T1 (hr) 2014-12-19
IL195639A0 (en) 2009-09-01
MX2008015842A (es) 2009-01-09
EP2029561A1 (en) 2009-03-04
AR061478A1 (es) 2008-08-27
BRPI0713743B1 (pt) 2020-03-17
AU2007261953B2 (en) 2012-11-08
US20090182023A1 (en) 2009-07-16
NO20090234L (no) 2009-02-12
JO2999B1 (ar) 2016-09-05
BRPI0713743A2 (pt) 2012-11-06
ES2523410T3 (es) 2014-11-25
CY1115729T1 (el) 2017-01-25
GEP20125392B (en) 2012-02-10
DK2029561T3 (da) 2014-11-10
CN101506181A (zh) 2009-08-12
US8349879B2 (en) 2013-01-08

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190618