HK1129575A - Tooth enamel dissolution inhibitor - Google Patents

Description

Dissolution inhibitor for tooth enamel

Technical Field

The present invention relates to a tooth enamel dissolution (decalcification) inhibitor which can be used for inhibiting dissolution (decalcification) of enamel in a tooth.

Background

In recent years, food life has become abundant, and various foods have been developed in which functionality and flavor are required, but at present, there is an increasing number of foods in which tooth enamel is easily dissolved.

For example, the present inventors have found that acids such as citric acid, malic acid, and ascorbic acid have an action of promoting the secretion of human beta-defensin as an antimicrobial peptide, and reported that the use of these acids for promoting the secretion of human beta-defensin in the oral cavity is effective for the prevention or treatment of dental caries, periodontal disease, and halitosis (see patent document 1). On the other hand, when an acid is applied to the oral cavity, the acid may dissolve (decalcify) enamel forming the teeth.

Against the background of such conventional techniques, development of an effective enamel dissolution inhibitor for preventing the dissolution of enamel in teeth, thereby maintaining the healthy state of teeth and keeping the oral health has been desired.

Patent document 1: international publication WO2005/027893 pamphlet

Disclosure of Invention

The purpose of the present invention is to provide a tooth enamel dissolution (decalcification) inhibitor that can inhibit the dissolution of tooth enamel and maintain the healthy state of teeth.

The present inventors have conducted extensive studies to solve the above problems and found that guar gum, glucomannan, β -cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin and/or xanthan gum have an effect of inhibiting dissolution (decalcification) of enamel. In particular, it has been found that the above-mentioned ingredients exert an effective inhibitory effect on the dissolution of tooth enamel caused by citric acid, malic acid or ascorbic acid. The present invention has been completed based on these findings and through further repeated studies.

That is, the present invention provides the following forms of the invention:

item 1. a tooth enamel dissolution inhibitor characterized by containing at least one selected from the group consisting of guar gum, glucomannan, β -cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin, and xanthan gum.

Item 2. the dissolution inhibitor of item 1, comprising guar gum and/or glucomannan.

Item 3. the dissolution inhibitor according to item 1, which is used for inhibiting dissolution of tooth enamel by an acid.

Item 4. a food for inhibiting tooth enamel dissolution, characterized by containing at least one selected from the group consisting of guar gum, glucomannan, β -cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin, and xanthan gum.

Item 5. the food for inhibiting tooth enamel dissolution according to item 4, which comprises guar gum and/or glucomannan.

Item 6. a pharmaceutical for inhibiting tooth enamel dissolution, which comprises at least one selected from the group consisting of guar gum, glucomannan, β -cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin and xanthan gum.

Item 7. the pharmaceutical preparation for inhibiting tooth enamel dissolution according to item 6, which comprises guar gum and/or glucomannan.

Item 8 the pharmaceutical product for inhibiting dissolution of enamel in tooth according to item 6, which is used for inhibiting dissolution of enamel in tooth caused by acid.

Item 9. an oral product for inhibiting tooth enamel dissolution, comprising at least one selected from the group consisting of guar gum, glucomannan, β -cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin, and xanthan gum.

Item 10. the oral product for inhibiting tooth enamel dissolution according to item 9, comprising guar gum and/or glucomannan.

Item 11. the oral product for suppressing dissolution of tooth enamel according to item 9, for suppressing dissolution of tooth enamel by acid.

Item 12. a method of inhibiting dissolution of enamel in a tooth, characterized by applying an effective amount of at least one selected from the group consisting of guar gum, glucomannan, beta-cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin, and xanthan gum to the oral cavity.

Item 13. the method of item 12, wherein an effective amount of guar gum and/or glucomannan is applied to the oral cavity.

The method according to item 12, which is a method for inhibiting dissolution of enamel in a tooth by an acid.

Item 15. use of at least one selected from the group consisting of guar gum, glucomannan, beta-cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin, and xanthan gum in the manufacture of a tooth enamel dissolution inhibitor.

Item 16. use of guar gum and/or glucomannan in the manufacture of a tooth enamel dissolution inhibitor.

The use according to item 15, wherein the tooth enamel dissolution inhibitor is useful for inhibiting dissolution of tooth enamel by an acid.

Effects of the invention

The tooth enamel dissolution (decalcification) inhibitor of the present invention is useful for maintaining oral health because it has an excellent effect of inhibiting tooth enamel dissolution and can maintain the healthy state of teeth.

Detailed Description

The tooth enamel dissolution inhibitor of the present invention is characterized by containing at least one of guar gum, glucomannan, β -cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin, and xanthan gum (hereinafter, these may be simply referred to as an active ingredient).

The above-mentioned active ingredients are all known ingredients having practical effects in the fields of food and pharmaceutical products. The molecular weight and the like of the above-mentioned active ingredient which can be used in the dissolution inhibitor of the present invention are not particularly limited. In the present invention, hyaluronic acid as the active ingredient may be used in the form of a salt.

In the present invention, among the above active ingredients, guar gum and glucomannan are preferable from the viewpoint of more effectively suppressing the dissolution of enamel in teeth.

In the present invention, the above active ingredients may be used alone in 1 kind, or in combination in 2 or more kinds.

The dissolution inhibitor of the present invention is excellent particularly in the inhibition effect on tooth enamel dissolution by an acid, particularly tooth enamel dissolution by citric acid, malic acid or ascorbic acid. That is, the dissolution inhibitor of the present invention is preferably used at the time of or after the ingestion of an acid-containing food, particularly at the time of or after the ingestion of a food containing citric acid, malic acid or ascorbic acid.

The dissolution inhibitor of the present invention is a substance that inhibits dissolution of tooth enamel when applied in the oral cavity, and can be used in the fields of foods, medicines, and oral products.

The dissolution inhibitor of the present invention can be used as it is or as a food, a pharmaceutical or an oral product. The dissolution inhibitor of the present invention can be used as a food, a pharmaceutical (including quasi drugs) or an oral product by mixing the above-mentioned active ingredient with a carrier acceptable in food hygiene or in pharmaceutical industry, and further mixing other ingredients such as additives as needed.

The method of using the dissolution inhibitor of the present invention is not particularly limited, and for example, the dissolution inhibitor can be applied to the oral cavity 1 to 10 times per day in an amount of 0.001 to 20g per day of the active ingredient. In addition, the dissolution inhibitor of the present invention is preferably used by being retained in the oral cavity for, for example, about 1 second or more after being applied to the oral cavity.

When the dissolution inhibitor of the present invention is prepared as a food, a sweetener, a coloring agent, a preservative, a thickener, a stabilizer, a gelling agent, a starch adhesive, an antioxidant, a coloring agent, a bleaching agent, a mold inhibitor (anti-mold agent), a yeast activator, a gum base, a flavor, an acidulant, a seasoning, a tofu coagulant, an emulsifier, a pH adjuster, brine, a bulking agent, a nutrient supplement, and the like may be added as necessary in addition to the above-mentioned active ingredients. When the dissolution inhibitor of the present invention is prepared as a food, it can be prepared, for example, in the form of a beverage (carbonated beverage, refreshing beverage, milk beverage, alcoholic beverage, fruit juice beverage, tea, nutritional beverage, etc.), powdered beverage (powdered fruit juice, powdered soup, etc.), snack (chewing gum, tablet (cookies), sugar, biscuit, gummy candy (gummy), wafer, biscuit, jelly, etc.), bread, noodle-type food, cereal, jam, seasoning (sauce (souce), seasoning (dressing), etc.), etc. Among these, preferable examples include a cool beverage, a fruit juice beverage, a chewing gum, a sheet-like food, and a gummy candy. The dissolution inhibitor of the present invention prepared as a food can be used as a food for inhibiting the dissolution of tooth enamel, and is useful as a food for special health care, a food for nutritional supplement, a food for patients, and the like. When the dissolution inhibitor of the present invention is prepared into a food, the mixing ratio of the active ingredients in the food may be appropriately set according to the kind of the active ingredients to be used, the form of the food, the daily suitable amount of the active ingredients, and the like. The total amount of the active ingredients is 0.001 to 100% by weight, preferably 0.001 to 80% by weight, and more preferably 0.005 to 50% by weight, based on the total weight of the food.

When the dissolution inhibitor of the present invention is prepared into a pharmaceutical product, a binder, a disintegrant, a lubricant, a wetting agent, a buffer, a preservative, a perfume, and the like may be optionally mixed as needed in addition to the above active ingredients. When the inhibitor is formulated into a pharmaceutical product, the form thereof is not particularly limited. Examples of the agent include a film, a troche, a liquid, a powder, a tablet, a granule, a capsule, and a syrup. Among them, liquid preparations, films and troches can be cited as preferable forms. When the dissolution inhibitor of the present invention is prepared into a pharmaceutical product, the mixing ratio of the active ingredients in the pharmaceutical product can be appropriately set according to the kind of the active ingredients to be used, the form of the pharmaceutical product, the daily suitable amount of the active ingredients, and the like. Examples thereof include 0.001 to 100% by weight, preferably 0.001 to 80% by weight, and more preferably 0.005 to 50% by weight of the total amount of the active ingredient based on the total weight of the drug. The dissolution inhibitor of the present invention prepared as a pharmaceutical product can be used as a pharmaceutical product for inhibiting the dissolution of enamel in teeth.

When the dissolution inhibitor of the present invention is prepared into an oral product, various additives such as various surfactants, pigments (dyes and pigments), flavors, preservatives, bactericides (antibacterial agents), thickeners, antioxidants, chelating agents, fresheners, deodorants, pH adjusters, and the like may be mixed as necessary. Specific examples of the oral product include toothpaste, mouthwash, mouth freshener, and gargle. When the dissolution inhibitor of the present invention is prepared into an oral product, the mixing ratio of the active ingredients in the oral product can be appropriately set according to the kind of the active ingredients to be used, the form of the oral product, the daily suitable amount of the active ingredients, and the like. Examples thereof include 0.001 to 100% by weight, preferably 0.001 to 80% by weight, and more preferably 0.005 to 50% by weight of the total amount of the active ingredients, based on the total weight of the oral product. The dissolution inhibitor of the present invention, which is formulated into an oral product, can be used as an oral product for inhibiting the dissolution of tooth enamel.

Examples

The present invention will be described below by referring to test examples and examples, but the present invention is not limited to these examples.

Test example 1

In order to evaluate the inhibitory effect of each test substance on the dissolution (decalcification) of enamel in teeth, the following test was performed using a hydroxyapatite sintered body as a model of enamel in teeth.

To 2% by weight of citric acid adjusted with ultrapure water, test substances at the prescribed concentrations shown in Table 1 were added, and 10ml of a test solution adjusted to pH2.5 with sodium hydroxide was prepared. 10ml of the test solution and 1 piece (720mg, 10X 2mm) of a hydroxyapatite sintered body (manufactured by APP-100, ペンタツクス Co., Ltd.) were put into a 15ml polypropylene tube, and the tube was sealed and exposed to vibration for 2 days under a condition of about 120 times/min in the horizontal direction. After the exposure, in each test solution, the amount of phosphorus eluted from the hydroxyapatite sintered body was measured by high-frequency inductively coupled plasma emission spectrometry (ICP-AES). In addition, as a negative control, a 2 wt% citric acid solution (ph 2.5 adjusted with sodium hydroxide) was used as a test solution, and the test was performed in the same manner as described above. In addition, as a positive control, CaCl was used₂(10mM) As a test substance, the test was carried out in the same manner as described above. The phosphorus dissolution rate (%) in each test substance was calculated by taking the amount of phosphorus dissolved in the negative control as 100%.

The results obtained are shown in table 1. From these results, it was found that guar gum, glucomannan, β -cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin, and xanthan gum were effective in suppressing the elution of phosphorus from the hydroxyapatite sintered body caused by citric acid. In particular, it was confirmed that guar gum and glucomannan have an extremely high effect of inhibiting phosphorus elution from the sintered hydroxyapatite body.

[ Table 1]

Example 1 chewing gum

(wt%)

Gum base 20

Sorbitol 40

Maltitol 5

Mannitol 20

Malic acid 10

Guar acid 1

Proper amount of glycerin

Proper amount of perfume

Total 100

Example 2 chewing gum

In the composition of example 1 above, equal amounts of glucomannan, beta-cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin or xanthan gum were used instead of guar gum.

Example 3 mouthwash

(wt%)

Ethanol 15

Glycerol 10

Polyoxyethylene hydrogenated castor oil 2

Saccharin sodium 0.15

Sodium benzoate 0.05

Citric acid 10

Pectin 1

Proper amount of perfume

Proper amount of colorant

Proper amount of pure water

The total content is 100%

Example 4 mouthwash

In the composition of example 3 above, guar gum, glucomannan, beta-cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan or xanthan gum was used in equal amounts instead of pectin.

EXAMPLE 5 breath freshening Agents

(wt%)

Glucomannan 2

L-menthol 1

L-ascorbic acid sodium salt 20

Refined white sugar 76

Proper amount of perfume

The total content is 100%

EXAMPLE 6 breath freshening Agents

In the composition of example 5 above, guar gum, beta-cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin or xanthan gum were used in equal amounts instead of glucomannan.

Claims (17)

1. A tooth enamel dissolution inhibitor characterized by containing at least one selected from the group consisting of guar gum, glucomannan, beta-cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin and xanthan gum.

2. The dissolution inhibitor according to claim 1, comprising guar gum and/or glucomannan.

3. The dissolution inhibitor according to claim 1, which is used for inhibiting dissolution of tooth enamel by an acid.

4. A food for inhibiting tooth enamel dissolution, which comprises at least one selected from the group consisting of guar gum, glucomannan, beta-cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin and xanthan gum.

5. The food for inhibiting tooth enamel dissolution according to claim 4, comprising guar gum and/or glucomannan.

6. A pharmaceutical preparation for inhibiting tooth enamel dissolution, which comprises at least one selected from the group consisting of guar gum, glucomannan, beta-cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin and xanthan gum.

7. The medicine for suppressing dissolution of enamel in tooth according to claim 6, which comprises guar gum and/or glucomannan.

8. The drug for suppressing dissolution of enamel in tooth according to claim 6, which is used for suppressing dissolution of enamel in tooth caused by acid.

9. An oral product for inhibiting tooth enamel dissolution, comprising at least one selected from the group consisting of guar gum, glucomannan, beta-cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin and xanthan gum.

10. An oral product for inhibiting enamel dissolution according to claim 9 comprising guar gum and/or glucomannan.

11. The oral product for suppressing dissolution of enamel in a tooth according to claim 9, which is used for suppressing dissolution of enamel in a tooth caused by an acid.

12. A method for inhibiting tooth enamel dissolution, characterized in that an effective amount of at least one selected from the group consisting of guar gum, glucomannan, beta-cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin and xanthan gum is applied in the oral cavity.

13. The method of claim 12, wherein an effective amount of guar gum and/or glucomannan is applied in the oral cavity.

14. The method according to claim 12, which is a method for inhibiting dissolution of enamel in a tooth caused by an acid.

15. Use of at least one selected from the group consisting of guar gum, glucomannan, beta-cyclodextrin, tragacanth gum, carrageenan, locust bean gum, hyaluronic acid, pullulan, pectin and xanthan gum in the manufacture of a tooth enamel dissolution inhibitor.

16. Use of guar gum and/or glucomannan for the manufacture of a tooth enamel dissolution inhibitor.

17. The use according to claim 15, wherein the tooth enamel dissolution inhibitor is useful for inhibiting acid-induced dissolution of tooth enamel.