HK1128628A - Oral care regimen - Google Patents

Description

Oral care regimen

Cross Reference to Related Applications

This application claims priority to U.S. provisional patent application serial No. 60/798,940, filed 2006, month 5, and day 9, the contents of which are incorporated herein by reference.

Background

After professional tooth cleaning by a dentist or hygienist, the consumer reports a sensation of refreshment, satisfaction, cleanliness, and general well-being similar to those experienced after spa or beauty. Thus, there is a need in the art for an at-home oral care regimen for allowing consumers to recreate the "extra-clean" mouthfeel and associated sensations of well-being experienced after professional tooth cleaning.

Disclosure of Invention

The present invention includes methods of cleaning oral surfaces, maintaining oral health, and/or increasing oral health. Such methods include contacting the oral surface with the primary oral care composition at least once a day, and contacting the oral surface with the periodic oral care composition at least once over a period of about 42 days. Periodic oral care compositions suitable for use in the method include a first abrasive having an Einlehner hardness of greater than about 5mg loss per 100,000 revolutions (5mg loss per 100,000 revolutions); and a second abrasive having an Einlehner hardness of less than about 5mg loss per 100,000 revolutions. The ratio of the first abrasive to the second abrasive in the periodic oral care composition is from about 1:1.6 to about 1.6: 1. The periodic oral care composition is characterized by a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200. Additionally or alternatively, the method may include those wherein the second abrasive comprises silica and has a height of greater than about 90cm³Oil absorption per 100g and/or Einlehner hardness less than about 5mg loss per 100,000 revolutions. The ratio of the first abrasive to the second abrasive can be about 1:1.6 to about 1.6: 1. In oral compositionsThe total amount of first and second abrasives present may be greater than about 25% by weight of the composition and/or the oral composition has a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200.

Detailed Description

The present invention provides regimen methods of cleaning oral surfaces to remove, for example, bacteria, food particles, biofilm, plaque, and/or other agents that may cause or contribute to various oral conditions, such as halitosis, poor oral health, gingivitis, or periodontitis. The regimen methods of the present invention also provide a smooth, polished feel and appearance to the user's tooth surfaces that can be perceived as a "clean feel" comparable to the professional post-cleaning experience. Methods of maintaining oral health and/or increasing oral health are also provided.

The present invention is an oral care regimen comprising contacting an oral surface with at least two oral care compositions at different time increments. The oral surfaces to be treated include all within the oral cavity. Exemplary surfaces include hard tissue (e.g., teeth) and soft surfaces (e.g., gums and tongue).

One of the oral care compositions used in the regimen methods of the present invention is a primary oral care composition. The primary oral care composition may be any known or to be developed in the art and may take any form. For example, the primary oral care composition may be in the form of a lotion, cream, gel, fluid, suspension, film, patch, gum (gum), lozenge, confection, or semi-solid pates or stick. The primary oral care composition may be a conventional toothpaste, such as in COLGATETrade mark (Colgate-palm olive Company, New York, New York) or in CRESTTrademark (Procter)& Gamble Corporation，Cincinnati，Ohio) those sold. Alternatively, the primary oral care composition can be any of those described below, for example, U.S. patent No.4,721,614; 4,894,220; 4,986,981, respectively; 5,037,635, respectively; 5,156,835, respectively; 5,288,480, respectively; 5,344,641; 5,538,715; 5,776,435 and U.S. patent application publication nos. 2004/0126332, 2004/0136924, 2005/0019273, 2005/0271601, and 2005/0271602, the contents of each of which are incorporated herein by reference.

The primary oral care composition may comprise one or more agents such as humectants, solvents, thickeners, surfactants, abrasives, flavorants, colorants, viscosity and/or rheology modifiers, gums (gum), polymers, sweeteners, and the like. Examples of agents that may be present in the primary oral care composition include antibacterial agents, plaque dispersing agents, anti-adhesion agents, anti-caries (anticaries) agents, desensitizing agents, flavorants, colorants, stannous ion agents, triclosan monophosphate, chlorhexidine, alexidine, hexetidine, sanguinarine, benzalkonium chloride, salicylanilide, domiphen bromide, cetylpyridinium chloride, tetradecylpyridinium chloride, N-tetradecyl-4-ethylpyridinium chloride, octenidine, delmopinol, octapinol, nisin, zinc ion agents, copper ion agents, essential oils, furanones, bacteriocins, ethyl lauroyl arginine esters, magnolia extract, metal ion sources, arginine bicarbonate, and magnolol, magonol, ursolic acid, ursic acid, morin, sea buckthorn extract, peroxides, phytoperoxides, and mixtures thereof, Enzymes, camellia extract, flavonoids, flavans, halogenated diphenyl ethers, creatine, and/or propolis.

In the practice of the methods of the present invention, the primary oral care composition may be applied to or contacted with the oral surface at least once a day. In some embodiments, the application of the primary oral care composition may be performed two, three, four, five, six, seven, or up to fifteen times per day.

The oral surface may be contacted with the primary oral care composition using any means known or to be developed in the art; this manner may vary depending on the primary oral care composition form. Exemplary means of contacting the primary oral care composition with the oral surface include use of an implement (such as a brush, toothbrush, stick, sponge, cotton swab), lavage, chewing, adjacent placement, and application of a dissolved confection.

Another oral care composition for use in the methods of the present invention is a periodic oral care composition. The periodic oral care composition has a pellicle cleaning ratio ("PCR") of greater than 100 while having a radiotracer dentin abrasion ("RDA") of less than 200. In certain embodiments, the RDA is less than or equal to about 175 while still having a PCR in excess of about 100. In some embodiments, the RDA is less than 165. (methods of performing PCR and RDA are described, for example, in U.S. Pat. Nos. 5,939,051 and 6,290,933, both of which are incorporated herein by reference in their entirety.)

The periodic oral care composition comprises a first abrasive and a second abrasive; such abrasives are described in U.S. patent application serial No. 60/752,340, filed on 21/12/2005, the contents of which are incorporated herein by reference.

In certain embodiments, the periodic oral composition comprises a first abrasive having an Einlehner hardness of greater than about 5mg loss per 100,000 revolutions (5mg loss per 100,000 revolutions) and a second abrasive having an Einlehner hardness of less than about 5mg loss per 100,000 revolutions. The first particles having an einlehner hardness of greater than 5mg loss per 100,000 revolutions have a primary (primary) polishing function when they contact the oral surface. The second particles having an einlehner hardness of less than about 5mg loss per 100,000 revolutions have a primary cleaning function because they are softer particles. In certain embodiments, the second particle has a hardness of greater than about 10 mg loss per 100,000 revolutions, and in other embodiments, greater than about 15 mg loss per 100,000 revolutions.

The first abrasive of the periodic oral care composition can be a cleaning abrasive having a hardness less than or equal to the oral surface to be treated, and the second abrasive is a polishing abrasive having a hardness greater than or equal to the oral surface to be treated.

The first abrasive and the second abrasive of the periodic oral care composition each have a particle size. In certain embodiments, the first particle size is smaller than the second particle size. The average particle size may be measured, for example, using a Malvern particle size analyzer, model Mastersizer S, Malvern Instruments, inc.

In certain embodiments, the average particle size of the first abrasive is less than about 11 μm, preferably less than about 10 μm. For example, examples of suitable abrasives have an average particle size of about 7 μm to 11 μm. Some abrasives have a particle size of less than 5 μm. In other embodiments, the average particle size of the second abrasive is greater than about 8 μm, preferably greater than about 10 μm. In some embodiments, the average particle size of the second abrasive can be about 8 μm to about 14 μm.

Any orally or cosmetically acceptable abrasive that achieves the above requirements can be selected for use in the periodic oral care composition. Suitable abrasives include, but are not limited to: silica, silicates, silicon, alumina (including calcined alumina), aluminosilicates (such as bentonite, zeolite, kaolin and mica), diatomaceous earth (silica or diatomaceous earth), pumice, calcium carbonate, cuttlebone (cuttlebone), insoluble phosphates, composite resins (such as melamine, phenolic and urea resins), polycarbonates, silicon carbide, boron carbide, microcrystalline wax, microcrystalline cellulose (including combinations of colloidal microcrystalline cellulose and carboxymethylcellulose, available under the trade name AVICEL @)Commercially available from FMC Biopolymer of philiadelphia, Pennsylvania, u.s.a) and combinations and derivatives of all of the above. "mica" refers to any of a group of hydrated aluminum silicate minerals having a flat morphology and cracks in a perfect matrix (of mica). The mica may be, for example, mica boards, mica shavings or mica platelets, exemplified by muscovite, biotite or phlogopite type mica. Insoluble phosphates useful as abrasives include orthophosphates, polymetaphosphates and pyrophosphates. Illustrative examples are dicalcium orthophosphate dihydrate, dicalcium phosphate dihydrate, phosphoric acidCalcium hydrogen phosphate, calcium pyrophosphate, beta-calcium pyrophosphate, tricalcium phosphate, calcium metaphosphate, potassium metaphosphate, and sodium metaphosphate.

Synthetic silicas include silica gels and precipitated silicas, which can be prepared, for example, by neutralizing aqueous silicate solutions with a strong mineral acid. In silica gel preparation, the silica hydrogel is formed and is typically washed to reduce the salt content. The washed hydrogel may be ground to the desired size or otherwise dried to the point that its structure no longer changes due to shrinkage. When preparing such synthetic silicas, the objective is to obtain an abrasive that provides maximum cleaning (i.e., removal of the stained pellicle) with minimal damage to the enamel and other oral tissues.

Useful abrasives for preparing periodic oral compositions include high cleaning, low structure silica abrasives, such as those available under the trade nameXWA or783 from Davison chemical Division of W.R.Grace&Of Baltimore, MD.XWA650 is a silica hydrogel composed of colloidal silica particles. An exemplary silica hydrogel includes colloidal silica particles having an average particle size of about 3 μm to about 12 μm and more preferably about 5 μm to about 10 μm and a pH range of 4 to 10, preferably 6 to 9, when measured as a 5% by weight slurry. The particles of the XWA650 contain about 10 wt% to about 35 wt% water, have an average particle size of about 5 μm to about 12 μm, an Einlehner hardness of greater than or equal to about 5mg loss per 100,000 revolutions to about 20mg loss per 100,000 revolutions, less than 90cm³Per 100g, e.g. about 40cm³100g to about 90cm³Oil absorption of 100 g. The abrasive has a thickness of 100m²G to 700m²Brucel-Emmett-Teller (BET) surface area/g. The XWA650 has a brightness of 96.8 technidyne. Such abrasives are described in U.S. Pat. No.6,290,933The disclosure is incorporated by reference herein in its entirety.

Another high cleaning silica abrasive that can be included in the periodic composition acts asXWA 300 is sold as a silica hydrogel containing from about 10% to about 25% by weight water, and has an average particle size of from about 2 μm to about 4 μm. The particles have a size ranging from 150m²G to 400m²BET surface area per g of silica. The XWA 300 abrasive has less than 90cm³Oil absorption per 100g of silica; at boiling (no CO)₂) The pH in a 5% w/w suspension in demineralized water is equal to or greater than 8.5. Such abrasives are disclosed in U.S. Pat. No.5,939,051, which is incorporated herein by reference in its entirety.

Another suitable high cleaning silica that may be included in the periodic composition comprises a silica product wherein the particles are from about 5 wt% to about 35 wt% water, have an average particle size of from about 7 μm to about 11 μm, an Einlehner hardness of from 12 to about 19, and about 50cm³100g to about 65cm³Oil absorption of 100 g. BET surface area of about 100m²G to about 700m²Per gram of silica. Brightness is generally reported to be greater than about 95 technidyne. The silica product can be used asA commercial route 105 was obtained from j.m. huber of Havre de Grace, Maryland, u.s.a.

Other abrasives that may be useful include typical cleaning silica abrasives, such as precipitated silicas, having an average particle size of up to about 20 μm, typically about 8 μm to about 14 μm, and greater than about 90cm³100g to about 110cm³An oil-absorbing structure of 100 g; such as marketed by j.m.huber115 having a pH of about 6.5-7.5 at 5% of the particles and an einlehner hardness of about 2mg loss per 100,000 revolutions to 4mg loss per 100,000 revolutions. This is achieved byThe brightness of the seed silica particles is greater than about 95. In certain embodiments, such a cleaning abrasive comprises a second abrasive of the oral composition.

In embodiments where the dentifrice is a clear or transparent gel, the colloidal silica abrasive is, for example, under the trademark "colloidal silica" or "colloidal silica" abrasiveIs as follows72 and74 or under the trademarkAlkali metal aluminum silicate complexes sold at 100 f are particularly useful because the refractive index of these abrasives is close to that of the gelling agent-liquid (including water and/or humectant) systems commonly used in dentifrices.

According to various embodiments of the present invention, the first and second abrasives are combined in the periodic composition to provide cleaning ability, mildness (relatively low abrasiveness), and aesthetically acceptable periodic care compositions. In various embodiments, the amount of the first abrasive to the second abrasive can be expressed as a ratio of the first abrasive to the second abrasive of about 1:1.6 to about 1.6: 1. For example, the ratio of the first abrasive to the second abrasive is about 1:1. The first abrasive and the second abrasive can each be present in the oral composition in an amount of about 13 to about 21% by weight of the oral composition.

In some embodiments, the amount of the first abrasive is from about 15% to about 19% by weight of the oral composition, and the amount of the second abrasive is from about 15% to about 19% by weight of the oral composition. In certain preferred embodiments, the first abrasive is present in an amount of about 17% by weight of the oral composition and the second abrasive is present in an amount of about 17% by weight of the oral composition. Thus, according to various embodiments of the present invention, the total amount of abrasive in the periodic oral care composition, including the first and second abrasives, is preferably greater than about 25%, more preferably greater than about 30%, and in some embodiments greater than about 35% of the total weight of the periodic oral care composition.

In some embodiments, the periodic oral composition comprises a first abrasive having an einlehner hardness of greater than about 5mg loss per 100,000 revolutions and a second abrasive having an einlehner hardness of less than about 5mg loss per 100,000 revolutions. The ratio of the first abrasive to the second abrasive is about 1:1.6 to about 1.6: 1. Also, the periodic oral composition has a PCR of greater than about 100 and an RDA of less than about 200. In certain embodiments, the RDA is less than about 175. In certain embodiments, the first abrasive has an oil absorption of less than about 90cm³A/100 g, and a second abrasive having an oil absorption of greater than about 90cm³100g of the total weight. In some embodiments, the ratio of the first abrasive to the second abrasive is about 1:1. The total amount of abrasive including the first and second abrasives is greater than about 30%. The first abrasive and the second abrasive are optionally present in an amount of about 17% each, respectively. In some embodiments, the first and second abrasives are present in an amount of about 15% to about 19%, respectively, by weight of the total periodic oral care composition. The first and second abrasives optionally comprise silica.

In certain embodiments, the periodic oral composition comprises: a first abrasive comprising silica having an Einlehner hardness greater than about 5mg loss per 100,000 revolutions and less than about 90cm³Oil absorption of 100 g. The periodic oral composition further comprises a second abrasive comprising silica, having an Einlehner hardness of less than about 5mg loss per 100,000 revolutions and greater than about 90cm³Oil absorption of 100 g. The first abrasive is present in an amount of about 13% to about 21% by weight, and likewise, the second abrasive is present in an amount of about 13% to about 21% by weight of the composition. In some embodiments, the first abrasive and the second abrasive are each present in an amount of about 15% to about 19% by weight of the periodic oral composition. In certain embodiments, the first and second abrasives are each present in an amount of about 17% by weight of the oral composition. PCR is preferably greater than 100 and RDA is preferably less than 200, and in certain embodiments, less than about 175. The total amount of first and second abrasives present in the oral composition is preferably greater than about 25%, and even more preferably greater than about 25%More preferably greater than about 30%.

In certain embodiments, the periodic oral composition comprises: a first abrasive comprising silica having less than about 90cm³Oil absorption per 100g and Einlehner hardness greater than about 5mg loss per 100,000 revolutions. The periodic oral composition further comprises a second abrasive comprising silica having a height of greater than about 90cm³Oil absorption of 100g and Einlehner hardness of less than about 5mg loss per 100,000 revolutions. The ratio of the first abrasive to the second abrasive is about 1:1.6 to about 1.6: 1. Further, the total amount of the first and second abrasives present in the oral composition is greater than about 25% by weight of the composition.

In certain embodiments, the periodic oral composition has a ratio of the first abrasive to the second abrasive of about 1:1.6 to about 1.6: 1. In particular embodiments, the active ingredient includes a non-ionic antimicrobial ingredient, such as a halogenated diphenyl ether like triclosan, which will be discussed in more detail below. In some embodiments, the first abrasive has less than about 90cm³Oil absorption of 100g and Einlehner hardness of greater than about 5mg loss per 100,000 revolutions, while the second abrasive has an Einlehner hardness of greater than about 90cm³Oil absorption of 100g and Einlehner hardness of less than about 5mg loss per 100,000 revolutions.

The periodic oral compositions described herein (both primary and periodic) can comprise an orally acceptable carrier. Conventional ingredients useful for forming carriers for oral care compositions are known to those skilled in the art. The carrier may be a liquid, semi-solid or solid phase. The oral composition may be in the form of a dentifrice (including toothpastes, tooth powders, and prophylaxis pastes), confectionaries (including gums, beads, and chews), film, coated gels (paint-on gels), or any other form known to those skilled in the art of abrasive application. The selection of the particular carrier component depends on the desired product form.

In certain preferred embodiments, the oral composition(s) are independently in the form of a dentifrice, wherein the exemplary carrier is substantially semi-solid or solid. The carrier may be aqueous, wherein the carrier preferably contains from about 5% to about 95% water. In other embodiments, the carrier may be substantially anhydrous. Carriers optionally include, for example, oral care actives, surface active agents such as surfactants, emulsifiers and foam modulators, viscosity modifiers and thickeners, lubricants, diluents, fillers, additional pH modifiers, colorants, preservatives, solvents, and combinations thereof. It should be understood that while the general nature of each of the above categories of materials may vary; there may be some common properties and any given material may serve multiple purposes within two or more of these material classes. As recognized by those skilled in the art, the oral composition(s) optionally include other materials in addition to those components previously described, including, for example, emollients, moisturizers, mouth feel agents, and the like. Examples of suitable oral composition carriers are disclosed in U.S. Pat. Nos. 6,669,929, 6,379,654, and 4,894,220, the contents of each of which are incorporated herein by reference.

Oral care active ingredients include, for example, antibacterial actives, anticalculus agents, anticaries agents, anti-inflammatory agents, anti-sensitivity agents, enzymes, nutrients, and the like. Those active agents useful herein are also disclosed in U.S. Pat. Nos. 6,290,933 and 6,685,921, the contents of each of which are incorporated herein by reference.

Any suitable fluoride ion source may be present in either or both oral compositions, such as those recited in U.S. Pat. No.5,080,887, the contents of which are incorporated herein by reference. Fluoride ion sources, acid phosphatase and pyrophosphatase inhibitors are well known in the art as anticaries agents. Examples of such sources are fluoride salts and compounds of inorganic metals and/or ammonium, such as: sodium fluoride, potassium fluoride, ammonium fluoride, calcium fluoride; copper fluorides, such as cuprous fluoride; zinc fluoride, barium fluoride; sodium silicofluoride, ammonium fluorosilicate, sodium fluorozirconate; and sodium monofluorophosphate, aluminum mono-and di-fluorophosphate, and fluorinated sodium calcium pyrophosphate. The fluoride source may also be an amine fluoride, such as olafluro (N '-octadecyltrimethylenediamine-N, N' -tris (2-ethanol) -dihydrofluoride). Preferred are sodium fluoride, amine fluoride, stannous fluoride, sodium Monofluorophosphate (MFP), and mixtures thereof.

Either or both of the oral compositions optionally comprise an anticalculus component, such as one or more of the anticalculus components recited in U.S. patent No.5,292,526, the contents of which are incorporated herein by reference. In various embodiments, the anticalculus component comprises one or more polyphosphates. The anticalculus composition can include at least one fully or partially neutralized alkali metal or ammonium tripolyphosphate or hexametaphosphate salt present in the oral composition in an effective anticalculus amount. The anticalculus component may also include at least one water-soluble, linear, molecularly dehydrated polyphosphate salt in an effective anticalculus amount. The anticalculus component may also include a mixture of potassium and sodium salts as polyphosphate anticalculus agents, at least one of the potassium and sodium salts being present in an effective anticalculus amount. Other useful anticalculus agents include polycarboxylate polymers and polyvinyl methyl ether/maleic anhydride (PVM/MA) copolymers, such as GANTREZ。

All other substances or molecules known to be useful in oral care compositions can be included in either or both of the daily or periodic compositions. For example, such additional molecules may include antibacterial agents, antiplaque agents, desensitizing agents, anti-inflammatory agents, colorants, thickeners, flavorants, surfactants, abrasives, anti-adhesion agents, anti-caries agents, organoleptic agents, and/or vitamins.

Other components that may be added to either or both compositions include stannous ion agents; triclosan; triclosan monophosphate; chlorhexidine; alexidine; hexetidine; sanguinarine; benzalkonium chloride; salicylanilide; domiphen bromide; cetylpyridinium chloride (CPC); tetradecylpyridinium chloride (TPC); n-tetradecyl-4-ethylpyridinium chloride (TDEPC); octenidine; delmopinol; (ii) octapinol; nisin; a zinc ion reagent; a copper ion reagent; essential oil; a furanone; bacteriocin, ethyl lauroyl arginine ester, magnolia extract, a source of metal ions, arginine bicarbonate, honokiol, magonol, ursolic acid, ursic acid, morin, hippophae rhamnoides extract, peroxide, enzymes, camellia extract, flavonoids, flavans, halogenated diphenyl ethers, creatine, and propolis.

Claims (16)

1. A method of cleaning oral surfaces, maintaining oral health and/or increasing oral health comprising:

a. contacting the oral surface with the primary oral care composition at least once a day, and

b. contacting an oral surface with the periodic oral care composition at least once over a period of about 42 days;

wherein the periodic oral care composition comprises a first abrasive having an Einlehner hardness of greater than about 5mg loss per 100,000 revolutions and a second abrasive having an Einlehner hardness of less than about 5mg loss per 100,000 revolutions, wherein the ratio of the first abrasive to the second abrasive is from about 1:1.6 to about 1.6:1, and wherein the periodic oral composition has a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200.

2. The method of claim 1, wherein (b) is effected by applying the periodic oral care composition to an oral surface using a brush.

3. The method of claim 1, wherein the primary oral care composition comprises an agent selected from the group consisting of abrasive agents, antibacterial agents, plaque dispersing agents, anti-adhesion agents, anti-caries agents, desensitizing agents, flavorants, colorants, and organoleptic agents.

4. The method of claim 1, wherein the primary oral care composition comprises a stannous ion agent; triclosan; triclosan monophosphate; chlorhexidine; alexidine; hexetidine; sanguinarine; benzalkonium chloride; salicylanilide; domiphen bromide; cetylpyridinium chloride (CPC); tetradecylpyridinium chloride (TPC); n-tetradecyl-4-ethylpyridinium chloride (TDEPC); octenidine; delmopinol; (ii) octapinol; nisin; a zinc ion reagent; a copper ion reagent; essential oil; a furanone; bacteriocin, ethyl lauroyl arginine ester, magnolia extract, a source of metal ions, arginine bicarbonate, honokiol, magonol, ursolic acid, ursic acid, morin, hippophae rhamnoides extract, peroxide, enzymes, camellia extract, flavonoids, flavans, halogenated diphenyl ethers, creatine, and propolis.

5. The method of claim 1, wherein the oral surface is contacted with the primary oral care composition from two to five times per day.

6. The method of claim 1, wherein the periodic oral care composition has a radioactive dentin abrasion of less than about 175.

7. The method according to claim 1, wherein the first abrasive of the periodic oral care composition has less than about 90cm³Oil absorption of 100g and a second abrasive having a height of greater than about 90cm³Oil absorption of 100 g.

8. The method according to claim 1, wherein the first abrasive of the periodic oral care composition has an average particle size of less than about 11 μm and the second abrasive has an average particle size of greater than about 8 μm.

9. The method according to claim 1, wherein the first abrasive of the periodic oral care composition is present in an amount of about 17% by weight and the second abrasive of the periodic oral care composition is present in an amount of about 17% by weight.

10. The method according to claim 1, wherein the total amount of the first and second abrasives in the periodic oral care composition is greater than about 30% by weight of the composition.

11. The method according to claim 1, wherein the first abrasive of the periodic oral care composition is present in an amount of about 13% to about 21% by weight and the second abrasive of the periodic oral care composition is present in an amount of about 13% to about 21% by weight.

12. The method of claim 1, wherein the first abrasive and the second abrasive of the periodic oral care composition each comprise silica.

13. The method of claim 1, wherein the oral surface is contacted with the periodic oral care composition 4 to 18 times over a period of 42 days.

14. The method of claim 1, wherein the oral surface is contacted with the periodic oral care composition 6 times within a period of 42 days.

15. A method of cleaning oral surfaces, maintaining oral health, and/or increasing oral health comprising

a. Contacting the oral surface with the primary oral care composition at least once a day, and

b. contacting an oral surface with a periodic oral care composition at least once over a period of about 42 days;

wherein the periodic oral care composition comprises a first abrasive comprising silica, has an Einlehner hardness of greater than about 5mg loss per 100,000 revolutions, and less than about 90cm³Oil absorption of 100g and the second abrasive comprises silica, has an Einlehner hardness of less than about 5mg loss per 100,000 revolutions, and greater than about 90cm³Per 100g of oil absorption, wherein the first abrasive is present in an amount of about 13% to about 21% by weight and the second abrasive is present in an amount of about 13% to about 21% by weight.

16. A method of cleaning oral surfaces, maintaining oral health, and/or increasing oral health comprising

c. Contacting the oral surface with the primary oral care composition at least once a day, and

d. contacting an oral surface with a periodic oral care composition at least once over a period of about 42 days;

wherein the periodic oral care composition comprises a first abrasive comprising silica having less than about 90cm and a second abrasive³Oil absorption of 100g and Einlehner hardness of greater than about 5mg loss per 100,000 revolutions, and the second abrasive comprises silica and has a hardness of greater than about 90cm³Oil absorption per 100g and an Einlehner hardness of less than about 5mg loss per 100,000 revolutions, wherein the ratio of the first abrasive to the second abrasive is from about 1:1.6 to about 1.6:1, and the total amount of the first and second abrasives present in the oral composition is greater than about 25% by weight of the composition, wherein the oral composition has a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200.