HK1128270B - Multi-chamber container - Google Patents

Description

Multi-chamber container

Technical Field

The invention relates to a multi-chamber container, the using method comprises the following steps: separately, various unstable medicaments (liquid, powder or solid) that change with time if prepared are contained and mixed under aseptic conditions at the time of administration.

Background

Some of the drugs administered to patients by intravenous injection are unstable drugs that undergo an undesirable change with time when prepared in advance. For example, when an amino acid injection and a glucose injection are prepared and stored, a mixture solution is browned by a so-called maillard reaction. In addition, when the fat emulsion and the electrolyte solution are mixed and stored, the fat component is aggregated; when the liquid containing phosphoric acid and the liquid containing calcium are mixed, calcium phosphate precipitation occurs, and thus an undesirable change occurs.

In many cases, these medicines are prepared by separately storing the components before mixing in a multi-chamber container. The multi-chamber container is provided with a plurality of chambers for storing medicines, respectively, and a partitioning weak seal portion openable by applying pressure from the outside is provided between the chambers. Such a multi-chamber container has a structure: the drug can be stored in a partitioned state by a partitioning weak seal part before use, and the drug solutions to be mixed can be mixed aseptically at the time of administration, however, recently, the following accidents (medical accidents) have been pointed out to be dangerous: forgetting to open the partition member, the liquid medicine in only 1 chamber is erroneously administered.

In order to prevent such an accident in advance, a multi-chamber medical container has been proposed in which the medicines contained in the respective chambers are mixed together and then administered. For example, the following multi-chamber medical container is proposed: a plurality of housing chambers are provided in series via a partitioning weak seal portion, a discharge weak seal portion is provided between at least one of the housing chambers and a discharge port, and the seal strength (joint strength) of the discharge weak seal portion is set to be greater than the seal strength of the partitioning weak seal portion (for example, see patent document 1). In this multi-chamber medical container, when the respective storage chambers are pressed to mix the medicines, the partitioning weak seal portion opens before the discharge weak seal portion, so that it is possible to prevent only the discharge weak seal portion from opening, and to prevent erroneous medicine administration.

In addition, a multi-chamber medical container in which the sealing strength of the discharge weak seal portion is set to be smaller than the sealing strength of the partitioning weak seal portion has also been proposed (for example, see patent document 2). In this multi-chamber medical container, when the medicine is administered, the partitioning weak seal portion is first opened by pressing the storage chamber away from the discharge port side to mix the medicines, and then the discharge weak seal portion is opened by pressing the entire container, the seal strength of the discharge weak seal portion is set to be small, so that the container has an advantage of easy opening.

Patent document 1: japanese laid-open patent publication No. 2002-136570

Patent document 2: japanese laid-open patent publication No. 2003-159310

Disclosure of Invention

Problems to be solved by the invention

However, if a difference in seal strength is provided between the partitioning weak seal portion and the discharge weak seal portion as in the above-described two conventional examples, the design conditions required for setting the seal width, the heating time, the heating temperature, the pressurizing force, and the like become complicated, and the manufacturing process also becomes complicated, which leads to a problem of an increase in cost. For example, if the seal width is set to be wide in order to improve the seal strength, there is a problem that the volume of the housing chamber becomes small; if the heating time is made longer, the productivity is lowered.

In addition, the weak seal portion is formed by accommodating the drug and the diluent by first pressure peeling and then thermally pressing and adhering the films to each other, and therefore, has a disadvantage that the bonding strength is low and it is easily opened by an external force. After shipment, external forces acting on the multi-chamber container during transportation or the like are difficult to completely eliminate, and there is a concern that: there is a possibility that an external force may not be applied to the multi-chamber container because of a problem in the handling method after the carrying-in.

For this reason, the following simple method needs to be provided: in order to prevent the weak seal portion from opening by an external force before administration, the bonding strength of the weak seal portion can be surely improved after the drug and the diluent are contained without increasing the seal width or extending the heating time. In addition, when the joint strength of the partitioning weak seal portion and the discharge weak seal portion is improved at the same time, since the closed space is enlarged after the partitioning weak seal portion is opened at the time of administration, it is also necessary to provide a device for easily opening the discharge weak seal portion.

The present invention has been made in view of such circumstances, and an object thereof is to provide a multi-chamber container which is easy to open at the time of administration and is inexpensive by improving the bonding strength of a weak seal portion.

Means for solving the problems

(1) In the multi-chamber container of the present invention, one end side of the medicine accommodating chamber is connected to the diluent chamber via a partitioning weak seal portion, and the other end side of the medicine accommodating chamber is connected to a hollow chamber having a mouth portion via a discharging weak seal portion, wherein a film material for improving the bonding strength of the partitioning weak seal portion and the discharging weak seal portion is stuck to the medicine accommodating chamber, and the discharging weak seal portion is provided with an easy-opening portion which is easy to be partially opened.

With this configuration, the partitioning weak seal portion and the discharge weak seal portion can be effectively reinforced and the bonding strength can be reliably improved by simple processing of attaching the film material to the medicine accommodating chamber by heat sealing or by attaching with an adhesive after accommodating the medicine and the diluent. This prevents the occurrence of such a problem that the partitioning weak seal portion and the discharge weak seal portion are inadvertently peeled off by an external force or the like before administration. In addition, when the drug is administered, first, the partitioning weak seal portion is opened by applying a pressing force to the diluent chamber to mix the drug and the diluent, and after confirming the mixed state, the easy-opening portion provided in the discharge weak seal portion can be opened by pressing the entire partitioning weak seal portion, and the drug can be administered via the empty chamber. In this way, since the weak seal portion can be reliably reinforced only by attaching the film material to the medicine accommodating chamber, the design and the manufacture are easy, and the medicine accommodating chamber can be provided at low cost. As the film material, for example, a gas barrier film for protecting the drug from oxygen or water vapor can be used, but the present invention is not limited to these materials.

(2) The film material may have a portion attached to one end side edge thereof overlapping the partitioning weak seal portion, and a portion attached to the other end side edge thereof overlapping the discharge weak seal portion, or may be adjacent to the mouth portion side of the discharge weak seal portion. With this structure, it has been verified that the partitioning weak seal portion and the discharge weak seal portion can be effectively reinforced, and the joint strength thereof is surely improved.

(3) The film material may have a portion bonded to one end side edge thereof adjacent to the diluent chamber side or the drug storage chamber side of the partitioning weak seal portion, and a portion bonded to the other end side edge thereof may overlap the discharge weak seal portion or may be adjacent to the mouth portion side of the discharge weak seal portion. With this structure, it has been verified that the partitioning weak seal portion and the discharge weak seal portion can be effectively reinforced, and the joint strength thereof is surely improved.

(4) The film material may be a gas barrier film that is substantially impermeable to gases and water vapor. With this configuration, the partitioning weak seal portion and the discharging weak seal portion can be effectively reinforced, and the medicine accommodated in the medicine accommodating chamber can be protected from oxygen or water vapor.

(5) The easy-open portion may be formed in a protruding shape toward the medicine accommodating chamber. With this structure, the total pressure applied to the periphery of the projecting end when the multi-chamber container is pressed becomes larger than that of the other region of the discharge weak seal portion, and therefore peeling from the projecting end is easily started.

(6) Preferably, the weak sealing portion for discharge has the easy-open portion and a straight portion continuous with the easy-open portion and extending substantially straight from both sides of the easy-open portion, the easy-open portion has a vertex at an end edge of the empty chamber side so as to be recessed in the empty chamber side, so that a convex shape is formed on the medicine containing chamber side, and the vertex of the end edge of the empty chamber side is formed so as to be positioned closer to the medicine containing chamber side than the end edge of the straight portion on the medicine containing chamber side. With this configuration, the easy-opening portion which starts peeling before the other portion due to the concentrated pressure at the time of unsealing can be peeled before the other portion, and the medicine containing chamber and the empty chamber can be opened at the earliest.

(7) A plurality of easy-open portions formed in the protruding shape may be provided. With this structure, peeling is made easier.

(8) The easy-open part is formed into a V shape, and the vertex angle of the easy-open part can be set to be 20-150 degrees. When the apex angle is set to such an angle, peeling can be easily performed from the top.

Effects of the invention

In the multi-chamber container of the present invention, since the partitioning weak seal portion and the discharging weak seal portion are reinforced by attaching the film material to the medicine accommodating chamber, it is possible to prevent the partitioning weak seal portion and the discharging weak seal portion from being unintentionally peeled off by an external force or the like before administration. In addition, when administering the drug, first, the partitioning weak seal portion is opened by applying a pressing force to the diluent chamber to mix the drug and the diluent, and after confirming the mixed state, the easy-to-open portion can be opened by pressing the whole to administer the drug. Such a multi-chamber container to which a film material is attached can be provided at a low cost because of its easy design and manufacture.

Drawings

FIG. 1 is a front view of a multi-chamber container according to a first embodiment of the present invention.

Fig. 2 is a sectional view of the multi-chamber container of the first embodiment.

Fig. 3 shows the results of a test for confirming the reinforcing effect of the weak seal portion by using the thin film material in the first embodiment.

Fig. 4(a) is an enlarged explanatory view of an easy-open portion of the first embodiment, and (b) is a sectional view taken along line a-a of (a).

FIG. 5 is a front view of a multi-chamber container of a second embodiment of the present invention.

Description of the reference numerals

1 medicine accommodating chamber

2 weak seal for partition

3 Diluent chamber

4 weak sealing part for discharge

5 empty chamber

6 mouth part

7 thin film material

8 easy-to-open part

71, 72 adhesive part

Detailed Description

Hereinafter, a multi-chamber container according to a first embodiment of the present invention will be described in detail with reference to the accompanying drawings.

Fig. 1 is a front view of a multi-chamber container, and fig. 2 is a sectional view. In these drawings, reference numeral 1 denotes a medicine accommodating chamber which accommodates various medicines such as antibiotics; 2 denotes a partitioning weak seal portion provided at one end side of the medicine accommodating chamber 1; 3 refers to the diluent chamber; 4 denotes a discharge weak seal portion provided on the other end side of the medicine accommodating chamber 1, and 5 denotes an empty chamber in an aseptic state; the discharge port 6 is formed by attaching a film material 7 for improving the bonding strength between the partitioning weak seal portion 2 and the discharge weak seal portion 4 to both the front and back surfaces of the medicine accommodating chamber 1 by heat sealing or an adhesive.

The multi-chamber container is formed with a partitioning weak seal portion 2 and a discharge weak seal portion 4 so as to divide an inner space, which is formed by sealing the entire periphery between outer peripheral portions of two resin plates (transparent resin plates) that are stacked, into three spaces (a medicine accommodating chamber 1, a diluent chamber 3, and an empty chamber 5). The multi-chamber container of the present embodiment is formed to be long in the longitudinal direction, and partitions the drug-containing chamber 1 and the diluent chamber 3 by the partitioning weak seal portion 2 extending in the transverse direction (direction perpendicular to the long dimension direction); the medicine accommodating chamber 1 and the empty chamber 5 are partitioned by the discharge weak seal 4 extending in the same direction as the partitioning weak seal 2, and thus the diluent chamber 3, the medicine accommodating chamber 1, and the empty chamber 5 are formed in this order from above in the longitudinal direction.

The film material 7 is attached such that the attaching portion 71 at one end side edge of the film material 7 overlaps and is attached to the partitioning weak seal portion 2, and the attaching portion 72 at the other end side edge overlaps and is attached to the discharge weak seal portion 4. That is, the film material 7 is bonded to the outer surfaces of the two transparent resin plates forming the medicine accommodating chamber 1, the diluent chamber 3, and the empty chamber 5 so as to cover the region defining the medicine accommodating chamber 1 from the outside in a state where the upper and lower bonding portions 71 and 72 are respectively overlapped with the partitioning weak seal portion 2 and the discharge weak seal portion 4.

The film material 7 may be, for example, a gas barrier film that is substantially impermeable to gas and water vapor, and may be appropriately selected when the gas barrier property is not an important condition. Examples of the gas barrier film include films having a gas barrier film layer formed as follows: silica and/or alumina is vapor-deposited on polyethylene terephthalate (PET), and the resulting film is adhered to an olefin resin such as Polyethylene (PE) in multiple layers.

By attaching the film material 7 to the medicine storage chamber 1, the medicine can be protected from water vapor or oxygen without using a desiccant or a deoxidizer. When the gas barrier film is used as the film material 7, the film material 7 is bonded to the outer surfaces of the two transparent resin plates forming the drug storage chamber 1, the diluent chamber 3, and the empty chamber 5 (sealing the region between the resin plates) at both ends in the width direction of the multi-chamber container. As a result, the entire periphery of the film material 7 covering the medicine-containing chamber 1 is sealed outside the medicine-containing chamber 1, and as a result, inflow of water vapor or oxygen from the surroundings can also be prevented. Further, since the film material 7 is transparent, the inside of the drug storage chamber 1 can be seen from the outside, and the state of the stored drug can be clearly confirmed, and the presence or absence of insoluble foreign matter and the like can be confirmed when the diluent is introduced from the diluent chamber 3 into the drug storage chamber 1 by breaking the partitioning weak seal 2 and mixed with the drug, and therefore, the occurrence of erroneous administration can be prevented.

Further, since the medicine storage chamber 1 is covered with the transparent film material 7, the contamination of foreign matter or the like can be clearly detected even in the manufacturing process. Moreover, the following advantages are also provided: for example, if a label printed on both sides is attached to one surface of the diluent chamber 3, the label can be seen through from the outside and read even when the medicine storage chamber 1 and the diluent chamber 3 are folded in two by the partitioning weak seal portion 2.

Further, since the diluent chamber 3 is connected to the medicine-accommodating chamber 1 via the partitioning weak seal portion 2, the partitioning weak seal portion 2 can be opened by pressing the diluent chamber 3 side of the multi-chamber container, and the medicine can be introduced into the empty chamber 5 in a state of being diluted with the diluent at a constant rate. Thus, the diluted drug can be administered through the empty chamber 5, and the occurrence of erroneous administration can be prevented. Further, since the empty chamber 5 having the mouth portion is provided in connection with the medicine accommodating chamber 1 covered with the gas barrier film 7 via the discharge weak seal portion 4, the gas barrier property is not an important requirement for the mouth portion 6 and the periphery thereof, and therefore, the material cost of the portion can be reduced. Further, since a conventional aluminum thin film is not used, it can be provided at a low cost, and it is more environmentally friendly and facilitates disposal.

Further, as described above, since the sticking portions 71 and 72 of the film material 7 stuck to the medicine accommodating chamber 1 are overlapped with the partitioning weak seal portion 2 and the discharging weak seal portion 4, the partitioning weak seal portion 2 and the discharging weak seal portion 4 can be effectively reinforced, and the joining strength thereof can be surely improved. This prevents the partitioning weak seal portion 2 and the discharge weak seal portion 4 from being unintentionally peeled off by an external force or the like before administration. The reinforcing effect by the application (heat sealing) of the film material 7 was confirmed by experiments. The test results are shown in fig. 3.

In the test results, as in sample 3, the fact that when the adhering portion (indicated as the gas-barrier seal position in the experiment) 72 of the film material 7 was overlapped with the discharge side of the discharge weak seal portion (indicated as the EPS seal portion in the experiment) 4, after the opening of the partitioning weak seal portion 2, the opening was not easily performed when the whole of the multi-chamber container was pressed, and a sufficient reinforcing effect was exhibited has been confirmed. Further, in this experiment, the easy-to-open portion 8 was not provided in the discharge weak seal portion 4, and only the reinforcing effect was confirmed. In the present embodiment, the partitioning weak seal portion 2 overlapping the other-side bonded portion 71 of the film material 7 is similarly reinforced to improve the bonding strength, but can be opened properly when the diluent chamber 3 is pressed. This is because the closed space has a small volume, and a large internal pressure can act on the partitioning weak seal portion 2, and therefore, the opening operation is not affected at all. Further, the other adhesive portion 71 of the film material 7 is adjacent to the diluent chamber 3 side or the drug storage chamber 1 side of the partitioning weak seal portion 2 without a gap, whereby the bonding strength of the partitioning weak seal portion 2 can be improved.

With the other samples 2, 4, although the effect was inferior to that of sample 3, a definite reinforcing effect was confirmed. Further, in sample 2, the pasted portion 72 was made adjacent to the discharge side of the discharge weak seal portion 4 without a gap; in the sample 4, the sticking portion 72 is overlapped with the medicine accommodating chamber 1 side of the discharge weak seal portion 4. The reinforcing effect is low in the sample 1 in which the sticking portion 72 is stuck with a space of 5mm from the discharge side of the discharge weak seal portion 4 and the sample 5 in which the sticking portion 72 is adjacent to the medicine accommodating chamber 1 side of the discharge weak seal portion 4. In addition, in the sample 6 in which the pasting portion 72 is separated from the medicine accommodating chamber 1 side of the discharge weak seal portion 4 by an interval of 5mm, there is no reinforcing effect and opening is easy. From the above results, it was confirmed that samples 2, 3 and 4 were used.

As described above, on the premise that the discharge weak sealed portion 4 and the partitioning weak sealed portion 2 are reinforced together, in the present embodiment, as shown in fig. 1, the discharge weak sealed portion 4 is provided with the easy-opening portion 8 which is easy to open the discharge weak sealed portion 4. That is, in the multi-chamber container of the present embodiment, the easy-opening portion 8 which is easy to open the discharge weak seal portion 4 is provided on the premise that the discharge weak seal portion 4 which is reinforced is opened in a state where the internal pressure generated by pressing the multi-chamber container is hard to act after the opening of the partition weak seal portion 2.

Specifically, the discharge weak seal portion 4 of the present embodiment includes: an easy-open portion 8 formed in a protruding shape toward the medicine accommodating chamber 1; straight portions 9, 9 continuous with the easy-opening portion 8 and extending substantially straight from both sides of the easy-opening portion 8. In the multi-chamber container shown in fig. 1 and 2, the bonded portion 72 on the other end side edge of the film material 7 is disposed along the discharge weak seal portion 4, and the bonded portion 72 is bonded so as to be partially overlapped with the discharge weak seal portion 4 (the easy-opening portion 8 and the straight portions 9 and 9) on the chamber side.

The easy-open portion 8 of the present embodiment is formed so as to protrude in a V-shape with the apex P positioned on the medicine-containing chamber 1 side. That is, the easy-open portion 8 is formed to have a peak AP at an end edge of the empty chamber 5 side so as to be recessed toward the empty chamber 5 side, and to have a convex shape toward the medicine accommodating chamber 1 side. In this way, when the easy penetration portion 8 is in a state of protruding in a V-shape (chevron shape), the angle α of the apex angle of the protruding end portion B is preferably set to 20 ° to 150 °.

Further, in this manner, the easy-open portion 8 protruding from the medicine accommodating chamber 1 side is formed as follows: the apex P of the easy-open portion 8 is located more inward (toward the medicine containing chamber 1) than the inner horizontal edge 72a (see fig. 1) of the adhering portion 72 of the film material 7 located toward the medicine containing chamber 1. The more preferable specific scheme is as follows: the easy-opening portion 8 is formed such that a vertex AP of an end edge of the easy-opening portion 8 on the empty chamber 5 side is located more inward (on the medicine containing chamber 1 side) than an end edge 90 of the straight portions 9 and 9 on the medicine containing chamber 1 side. The arrangement of the vertex p (ap) is an important condition for facilitating the opening of the discharge weak seal portion 4.

In such an easy-to-open portion 8, when the multi-chamber container is pressed, as shown in fig. 4(a) and (B), a pressure acts in the direction indicated by the arrow, and the total pressure acting on the outer periphery of the protruding end portion B (the periphery of the edge on the medicine-accommodating chamber 1 side) is greater than that in the other region of the discharge weak seal portion, so that the easy-to-open portion is easily peeled from the outer side of the protruding end portion B. That is, even if the pressing volume is increased, the easy-open portion 8 can be peeled off or opened from the outside of the protruding end B with a small pressing pressure before the other portions (the straight portions 9 and 9), and the entire discharge weak seal portion 4 can be easily opened due to the opening of the easy-open portion 8.

In the multi-chamber container having the above configuration, since the joining strength of the partitioning weak seal portion 2 and the discharge weak seal portion 4 is improved before the administration, the occurrence of the inconvenience of careless opening due to the external force is prevented. In addition, at the time of administration, first, the partitioning weak seal portion 2 is opened by applying a pressing pressure to the diluent chamber 3 to mix the drug and the diluent, and after confirming the mixed state, the easy-to-open portion 8 can be opened by pressing the whole to administer the drug. In this way, the multichamber container in which the film material 7 is stuck to the medicine accommodating chamber 1 can be provided at a low cost because of its easy design and manufacture.

Next, a multi-chamber container according to a second embodiment of the present invention will be described. In the multi-chamber container of the present embodiment, the same structure as that of the first embodiment or the structure corresponding to that of the first embodiment is given the same name and the same reference numeral and description thereof is omitted, except that the manner of sealing (the portion to which the gas barrier film is attached) in the vicinity of the easy-open portion is different, and therefore, the vicinity of the easy-open portion 8 (the weak sealing portion 4 for discharge (the easy-open portion 8) and the portion to which the film material 7 is attached) is mainly described.

In the multi-chamber container of the present embodiment, as shown in fig. 5, the discharge weak seal portion 4 is formed so as to extend in the width direction of the multi-chamber container (the direction perpendicular to the direction in which the medicine accommodating chamber 1, the diluent chamber 3, and the empty chamber 5 are aligned), and the easy-open portion 8 is formed by forming a projection shape at the middle portion of the discharge weak seal portion 4 toward the medicine accommodating chamber 1 side. Specifically, the discharge weak seal portion 4 includes the easy-open portion 8 and linear portions 9 and 9 continuous with the easy-open portion 8 and extending substantially straight from both sides of the easy-open portion 8.

The easy-opening portion 8 is formed to protrude in a V-shape so that the apex P is located on the medicament accommodating chamber 1 side, as in the first embodiment. That is, the easy-open portion 8 is formed of a bent region (V-shaped region) protruding toward the medicine accommodating chamber 1. The easy-opening portion 8 has a vertex AP at an end edge on the cavity 5 side so as to be recessed on the cavity 5 side and to form a convex shape on the medicine containing chamber 1 side, and the vertex AP at the end edge on the cavity 5 side is formed to be positioned closer to the medicine containing chamber 1 side than the end edges on the medicine containing chamber 1 side of the linear portions 9 and 9.

In contrast, the film material 7 of the present embodiment has a bonded portion 72 at the other end side edge (on the side of the empty chamber 5) extending over substantially the entire length in the width direction of the multi-chamber container, and overlaps the discharge weak seal portion 4 on the side of the empty chamber 5 (on the discharge side) in a strip-like region having a substantially constant width in the direction in which the drug storage chamber 1, the diluent chamber 3, and the empty chamber 5 are aligned in a row. That is, the bonded portion 72 on the other end side edge of the film material 7 is bonded over substantially the entire length in the width direction of the multi-chamber container so as to overlap only the linear portions 9 and 9 of the discharge weak seal portion 4 on the side of the empty chamber 5. Therefore, in the multi-chamber container of the present embodiment, the region surrounded by the bonded portion 72 of the film material 7 and the openable portion 8 is in a state where sealing, bonding of the film material 7, or the like is not performed.

As described above, the easy-opening portion 8 of the present embodiment is formed by the curved region protruding toward the medicine-accommodating chamber 1, and therefore, the apex AP is formed also at the end edge on the empty chamber 5 side. Further, as in the first embodiment, the easy-opening portion 8 of the present embodiment is formed such that the apex AP of the edge on the side of the empty chamber 5 is positioned closer to the medicine containing chamber 1 than the edge on the side of the medicine containing chamber 1 of the weak sealing portion 4 for discharge (linear portions 9, 9).

In the multi-chamber container having the above-described structure, the easy-open portion 8 is formed in a protruding shape toward the medicine-accommodating chamber 1, and therefore, the pressure when the multi-chamber container is pressed acts on the easy-open portion 8 intensively. As a result, the easy-open portion 8 preferentially starts peeling. In the multi-chamber container of the present embodiment, the apex AP of the edge on the empty chamber 5 side of the easy-opening portion 8 is located closer to the medicine containing chamber 1 side than the edge on the medicine containing chamber 1 side of the weak sealing portion 4 for discharge (linear portions 9, 9), and therefore the easy-opening portion 8 that preferentially starts peeling opens before the other portions (linear portions). Thus, even if the adhesive force is increased by attaching the film material 7 as described above, the entire discharge weak seal portion 4 is easily peeled off or opened due to peeling (or opening) of the easy-opening portion 8 at the time of opening (at the time of pressing the multi-chamber container), that is, the medicine accommodating chamber 1 and the empty chamber 5 are communicated with each other.

As described above, the multi-chamber container of the present embodiment can also produce the same operation and effect as the first embodiment. That is, in the multi-chamber container of the present embodiment, since the joint strength of the partitioning weak seal portion 2 and the discharge weak seal portion 4 is improved, it is possible to prevent the occurrence of such a problem that the opening is inadvertently performed by an external force before the administration. On the other hand, in the administration, the medicine can be diluted with the diluent by opening the partitioning weak seal portion 2 by pressing the multi-chamber container (from the diluent chamber 5 side). Even if the internal space (closed space) in which the drug storage chamber 1 and the diluent chamber 3 communicate with each other is enlarged and the internal pressure generated by pressing the multi-chamber container is reduced, the discharge seal 4 can be reliably and easily opened by providing the easy-to-open portion 8, and a diluted drug can be administered. In this way, the multichamber container in which the film material 7 is stuck to the medicine accommodating chamber 1 can be provided at a low cost because of its easy design and manufacture.

The present invention is not limited to any of the above embodiments, and design changes and improvements can be made as appropriate without departing from the spirit of the invention.

For example, if a sufficient reinforcing effect is obtained and the gas barrier property is not an important condition, the film material 7 may be attached to only one side. In the case of bonding by heat sealing, a material having heat sealability may be selected as the film material, or a film material having no heat sealability may be bonded with an adhesive.

In any of the above embodiments, the easy-open portion 8 is provided by the bent region (V-shaped), but the shape of the easy-open portion 8 is not limited to this, and for example, the easy-open portion 8 may be formed by a semicircular or semi-elliptical region protruding toward the medicine accommodating chamber 1. That is, the easy-opening portion 8 may be formed in a semicircular arc shape or a semicircular elliptical arc shape having a vertex AP at an end edge on the side of the hollow chamber 5 so as to be recessed on the side of the hollow chamber 5, and the vertex AP at the end edge of the semicircular arc shape or the semicircular elliptical arc shape may be formed at a position closer to the medicine containing chamber 1 than the end edge on the side of the medicine containing chamber 1 of the linear portions 9 and 9.

In this case, since the apex AP is formed at the end edge on the empty chamber 5 side of the easy-opening portion 8 and is positioned closer to the medicine containing chamber 1 side than the end edge 90 on the medicine containing chamber 1 side of the discharge weak seal portion 4 (the straight portions 9, 9 extending straight from the flow side of the easy-opening portion 8), even if the joining strength is increased by joining the joining portion 72 of the film material 7 so as to overlap the discharge weak seal portion 4, the discharge weak seal portion 4 can be opened easily and reliably at the time of unsealing.

Further, in any of the above embodiments, the easy-opening portion 8 of the discharge weak seal portion 4 is provided at only one place, but for example, a plurality of easy-opening portions 8 may be provided in the discharge weak seal portion 4. That is, the discharge weak seal portion 4 may be formed by providing a plurality of easy-open portions 8 and connecting the easy-open portions 8 with straight portions 9 extending on both sides thereof. In this way, since there are more places where the opening is easier and earlier than the straight portion 9, the opening of the discharge weak seal portion 4 can be made easier. However, in this case, in order to increase the bonding strength of the weak seal portions, it is naturally necessary to bond the bonded portions of the film material 7 so as to be at least close to or overlap the straight portions 9.

In any of the above embodiments, the easy-open portion 8 is formed to protrude in a chevron shape (V-shape) toward the medicine containing chamber 1, but for example, the easy-open portion 8 may be formed to protrude toward the medicine containing chamber 1 so as to have an external shape (square, rectangle, trapezoid, etc.) in a front view, and the edge on the empty chamber 5 side may be formed to correspond to the edge on the medicine containing chamber 1 side so that the empty chamber 5 side is recessed in an external shape (square, rectangle, trapezoid, etc.) in a front view. That is, both end edges of the easy-opening portion 8 on the medicine accommodating chamber 1 side and the hollow chamber 5 side may be formed to have corners (corner portions) at two or more positions, and may be formed to protrude from the medicine accommodating chamber 1 side and to be recessed from the hollow chamber 5 side. In this manner, the easy-opening portion 8 is peeled or opened from the corner of the end edge or the vicinity of the corner. However, if it is necessary to improve the ease of unsealing the easy-opening portion 8, the easy-opening portion 8 may be brought into a state in which the empty chamber 5 side is recessed, and more preferably, the edge on the empty chamber 5 side may be brought into a state in which the edge on the empty chamber 5 side has a vertex AP, and the vertex AP of the edge on the empty chamber 5 side may be positioned closer to the medicine containing chamber 1 side than the edge 90 on the medicine containing chamber 1 side of the linear portion 9.

Claims (21)

1. A multichamber container in which one end side of a medicine accommodating chamber is connected to a diluent chamber via a partitioning weak seal portion, and the other end side of the medicine accommodating chamber is connected to a space having a mouth portion via a discharging weak seal portion, wherein a film material for improving the bonding strength of the discharging weak seal portion is stuck to the medicine accommodating chamber, and an easy-opening portion which is easy to be partially opened is provided in the discharging weak seal portion, characterized in that a stuck portion at one end side edge of the film material is overlapped with the partitioning weak seal portion, and a stuck portion at the other end side edge is overlapped with the discharging weak seal portion, or is adjacent to the space side of the discharging weak seal portion.

2. A multi-chamber container in which one end side of a medicine accommodating chamber is connected to a diluent chamber via a partitioning weak seal portion, and the other end side of the medicine accommodating chamber is connected to a chamber having a mouth portion via a discharging weak seal portion, wherein a film material for improving the bonding strength of the discharging weak seal portion is stuck to the medicine accommodating chamber, and an easy-opening portion which is easy to be partially opened is provided in the discharging weak seal portion, characterized in that a stuck portion at one end side edge of the film material is adjacent to the diluent chamber side or the medicine accommodating chamber side of the partitioning weak seal portion, and a stuck portion at the other end side edge is overlapped with the discharging weak seal portion or adjacent to the chamber side of the discharging weak seal portion.

3. Multicompartment container according to claim 1 or 2 wherein the film material is a gas barrier film substantially impermeable to gases and water vapour.

4. The multi-chamber container according to claim 1 or 2, wherein the easy-open portion is formed in a protruding shape toward the medicine-housing chamber.

5. The multi-chamber container according to claim 3, wherein the easy-open portion is formed in a protruding shape toward the medicine-housing chamber.

6. The multi-chamber container according to claim 4, wherein the discharge weak seal portion has the easy-open portion and a straight portion continuous with the easy-open portion and extending substantially straight from both sides of the easy-open portion, the easy-open portion has a vertex at an end edge of the empty chamber side so as to be recessed in the empty chamber side so as to form a convex shape on the medicine containing chamber side, and the vertex of the end edge of the empty chamber side is formed so as to be positioned further toward the medicine containing chamber side than the end edge of the straight portion on the medicine containing chamber side.

7. The multi-chamber container according to claim 5, wherein the discharge weak seal portion has the easy-open portion and a straight portion continuous with the easy-open portion and extending substantially straight from both sides of the easy-open portion, the easy-open portion has a vertex at an end edge of the empty chamber side so as to be recessed in the empty chamber side so as to form a convex shape on the medicine containing chamber side, and the vertex of the end edge of the empty chamber side is formed so as to be positioned further toward the medicine containing chamber side than the end edge of the straight portion on the medicine containing chamber side.

8. The multi-chamber container according to claim 4, characterized in that a plurality of easy-open portions formed in the shape of said protrusions are provided.

9. The multi-chamber container according to claim 5, characterized in that a plurality of easy-open portions formed in the shape of said protrusions are provided.

10. The multi-chamber container according to claim 6, characterized in that a plurality of easy-open portions formed in the shape of said protrusions are provided.

11. The multi-chamber container according to claim 7, characterized in that a plurality of easy-open portions formed in the shape of said protrusions are provided.

12. The multi-chamber container as claimed in claim 1 or 2, characterized in that the easy opening portion is formed in a V-shape with its apex angle set to 20 ° to 150 °.

13. A multicompartment container according to claim 3 wherein the easy opening portion is formed in a V shape with an apex angle set at 20 ° to 150 °.

14. The multicompartment container according to claim 4 wherein the easy opening portion is formed in a V shape with its apex angle set at 20 ° to 150 °.

15. A multicompartment container according to claim 5 wherein the easy opening portion is formed in a V shape with an apex angle set to 20 ° to 150 °.

16. The multicompartment container according to claim 6 wherein the easy opening portion is formed in a V shape with its apex angle set at 20 ° to 150 °.

17. The multicompartment container as claimed in claim 7 wherein the easy opening portion is formed in a V shape with its apex angle set at 20 ° to 150 °.

18. The multicompartment container according to claim 8 wherein the easy opening portion is formed in a V-shape with its apex angle set at 20 ° to 150 °.

19. The multicompartment container according to claim 9 wherein the easy opening portion is formed in a V-shape with its apex angle set at 20 ° to 150 °.

20. The multicompartment container as claimed in claim 10 wherein the easy opening portion is formed in a V shape with its apex angle set at 20 ° to 150 °.

21. The multicompartment container according to claim 11 wherein the easy opening portion is formed in a V-shape with its apex angle set at 20 ° to 150 °.