HK1101504A - Atomizer for distributing liquids for medical purposes - Google Patents

Description

Nebulizer for dispensing a medical liquid

Technical Field

The present invention relates to a nebuliser for dispensing a liquid, such as a pharmaceutically active substance formulation (active substance formulations), for medical use from at least one liquid container mountable in a nebuliser { cartridge (cartridge) }, a cartridge and a system comprising a nebuliser and a cartridge mountable in the nebuliser.

Background

A known nebulizer includes, as a basic unit, a cartridge holder provided in a housing; a connector arranged on the shell and internally provided with a spraying device; and a connecting pipe system connecting the spray device and the cartridge holder, wherein the spray device has at least one nozzle body and the connecting pipe system has at least one passage in which a hollow plunger is displaceably mounted, wherein the hollow plunger comprises a valve body.

The hollow plunger inserted into these sprayers comprises a valve body. Once the hollow plunger is moved down to the open position, the valve body may cause a formulation component (formulation) or a mixed formulation inhalation flow to enter the channel portion downstream of the hollow plunger in the flow direction. As soon as the hollow plunger is moved upwards, the valve body closes the hollow plunger, and as the hollow plunger is moved further upwards, the formulation or mixture situated downstream of the hollow plunger in the flow direction is compressed to the desired pressure.

Such nebulizers can be used for the effective application of liquid pharmaceutical formulations by inhalation, in which case the quality of such liquid formulations must meet high standards. For a good distribution of the active substance in the lungs, a liquid formulation which does not comprise the use of propellant gases (propellant gases) is applied as an option by itself with the aid of inhalers or nebulizers suitable for this type of use. A particularly suitable nebulizer is one that can nebulize a small therapeutically necessary dose of a liquid formulation in a few seconds into an aerosol for therapeutic use suitable for inhalation. In this regard, to ensure optimal lung deposition, the duration of nebulization should be optimized in terms of time. According to the present invention, nebulizers are preferred in which the amount of active solution that has been nebulized by one stroke or several strokes is less than 100 microliters, preferably less than 50 microliters, more preferably less than 20 microliters, in order to provide an aerosol with an average particle size of less than 20 microns, preferably less than 10 microns.

Such an airless propellant dispensing drug Device for inhaling a liquid drug dose is described in detail in, for example, international patent application WO 91/14468 entitled "Atomizing devices and methods" and WO 97/12687. In such nebulizers, the drug solution is converted into a pulmonary treatment aerosol by high pressures of up to 500 bar.

In these known nebulizers, the active substance formulations are stored in the form of solutions in a reservoir. In this case, the solutions used must have sufficient storage stability and at the same time be used as they are as free as possible from further processing for medical purposes. Furthermore, these active substance formulations should not have any ingredients that can interact with the nebulizer to avoid either destroying the nebulizer, destroying the solution, or affecting the aerosol produced.

Atomization of the solution may be achieved by using a dedicated nozzle as described in, for example, WO 94/07607 or WO 99/16530.

Further improvements to the structure in this preferred inhaler are also disclosed in WO 97/12687.

The known nebulisers are portable by the patient at any time, since they are cylindrical and can be conveniently controlled in size to a length of less than 9 to 15 cm and a width of less than 2 to 4 cm. Such nebulizers use high pressure to eject a defined volume of a pharmaceutical formulation through a small nozzle to produce an inhalable aerosol.

EP 0918570 describes a nebulizer for nasal sprays whose core assembly includes a spring controlled plunger and nozzle device. A container can be inserted between the plunger and the nozzle, which container has a ram (ram) at the bottom, the top side of which is sealed by means of a seal. The seal of the container is opened prior to initial use by moving an external nozzle which is fitted into the sprayer through the seal.

However, the nebulisers described are primarily suitable for delivering stable solution formulations, that is to say formulation components which can be mixed stably with one another and which can be stored for a long period of time. Thus, for example, prerequisites in the case of the preparation of a composition comprising at least two active substances are: for example, the dosed active substances are stabilized at the same pH value in the same solvent.

Furthermore, devices for administering drugs are known from the prior art in various principles, the drugs being stored separately before administration and subsequently being supplied to the patient in the form of a cocktail.

WO 2004/011068 discloses an electronic system for administering a pharmaceutical composition.

WO 2004/011071 discloses a system for administering a medicament wherein two medicament containers are of different types.

WO 2004/011067 and 011070 also disclose systems for administering drug cocktails wherein 01170 claims administration of multiple inter-formulated drugs with drugs that are not suitable for inter-formulation.

WO 2004/011067 claims a simple system for administering drugs wherein the agents are stored in separate containers but can be delivered to the patient in a mixture.

Disclosure of Invention

The object of the present invention is to provide a nebulizer that can store and dispense formulations that are stable to storage under relatively different conditions, such as pH, solvents or additives.

It is another object of the present invention to provide a cartridge for storing a formulation.

It is a further subsidiary object of the invention to provide a system comprising a nebulizer and a cartridge.

According to the invention, the object is firstly achieved with a nebulizer in which a first hollow plunger is displaceably mounted in a first channel and a second hollow plunger is displaceably mounted in a second channel, wherein the first hollow plunger and the second hollow plunger extend into a cartridge holder. The term "hollow plunger" is used to describe a tubular plunger having an outer diameter dimension slightly less than the inner diameter dimension of the passageway. The first and second passages are preferably bores having a circular cross-section and extend in generally parallel relationship to each other. In this case, the channels perform two tasks, on the one hand they serve as guide portions for the axial movement of the hollow plunger mounted therein, and on the other hand the formulation of the active substance passes through them on its way to the nozzle body. The part of the passage from the nozzle body to the end of the hollow plunger downstream in the flow direction is at the same time a pressure chamber, the volume of which decreases gradually as the hollow plunger moves upwards. The front end of the hollow plunger in the flow direction extends into the cartridge holder.

Preferably the spraying device comprises a first nozzle body having at least one first nozzle outlet and a second nozzle body having at least one second nozzle outlet, wherein the first nozzle body is connected to the first passage and the second nozzle body is connected to the second passage. In this embodiment, the two different liquids pass through the atomizer completely separate from each other and only join on the outside of the device to form a cyclone cloud (aerosol cloud). Contact between the different formulations and the reactions caused thereby during storage and nebulisation can thus be minimised.

The first nozzle outlet of the first nozzle body and the second nozzle outlet of the second nozzle body may be inclined to each other so that the two liquids merge and are co-atomized outside the atomizer.

It has proven to be particularly advantageous if the first nozzle body has two nozzle outlets and the second nozzle body also has two nozzle outlets, wherein the two nozzle outlets of the nozzle bodies are preferably inclined to one another. In this case, the two liquids are atomized in a parallel relationship with respect to time to produce two interpenetrating, cyclone-like clouds. In principle, not only two separate nozzle outlets per nozzle head, but also more nozzle outlets are possible.

According to another embodiment, the spraying device has only one nozzle body, wherein the first and the second channel are each introduced into the nozzle body and each channel is provided with a first and a second nozzle outlet. In this case, the two flowing liquid streams form a common cyclonic-like cloud after being ejected from separate nozzle outlets. In this embodiment, the first nozzle outlet and the second nozzle outlet of the common nozzle body are also inclined to each other so that the two liquid streams merge in front of the nozzle body, thereby providing a common atomization.

Furthermore, multiple separate nozzle bodies, each having two or more nozzle outlets, can simultaneously produce different particle size formulations from different formulations. Thus, for example, a larger particle size of the first formulation may be administered for the treatment of upper respiratory tract disease, while a smaller particle size of the second formulation may be administered for the treatment of lower respiratory tract disease.

In a further preferred embodiment, the spraying device comprises a nozzle body in front of which, in the flow direction, a mixing channel is arranged, in which the first and second channels meet. The mixing passage supplies the mixed solution to the nozzle body. In this embodiment, it is also preferred to provide two nozzle outlets which are inclined to one another and which can be used to prepare a cyclonic shaped cloud.

As an alternative to the embodiments described above, the spraying device may also have a nozzle body with a plenum chamber disposed in the nozzle body, and the first and second channels meeting in the plenum chamber. In this embodiment, the mixing channel is moved into the nozzle body, which is called a plenum chamber, in distinction to the previous embodiments. A cyclonic shaped cloud may be prepared in a manner corresponding to that described in the above embodiments.

The stated objects of the invention are also achieved with a nebulizer in which at least one hollow plunger branches into a first and a second plunger part at its end adjacent to the cartridge holder, wherein the first and second plunger parts protrude into the cartridge holder. In this configuration, the hollow plunger is displaceably mounted in the channel. The hollow plunger branches off outside the channel into two plunger parts. In addition to the embodiment described above, the preparation of the mixture comprising the two formulations does not take place in the mixing or aeration chamber, but already in the hollow plunger. For the preparation of a cyclonic shaped cloud, the atomizer may also have a first and a second nozzle outlet in a single nozzle body, which are preferably inclined to one another.

In all embodiments, in case of multiple nozzle outlets, these inclined nozzle outlets may be oriented such that they form a liquid injection direction with an impact angle of preferably 20 ° to 160 °, more preferably 60 ° to 150 °, most preferably 80 ° to 100 °. This impingement angle is decisive for determining the impingement distance, i.e. the distance between the nozzle outlets where the two liquids meet. The impingement distance cannot be selected too large, otherwise an adequate spray cannot occur.

The nozzle outlets in the nozzle body are preferably arranged at a distance of 10 to 200 microns, more preferably at a distance of 10 to 100 microns, even more preferably at a distance of 30 to 70 microns, most preferably at a distance of 50 microns.

The valve body is preferably arranged at the end of the hollow plunger at the downstream end in the flow direction. This prevents backflow of the formulation or mixed formulation into the hollow plunger.

Ideally, the at least one nozzle body is fixed in position on the at least one channel.

The cartridge holder is preferably mounted in a removable manner.

A force receiving member may be provided in the housing to store a predetermined energy. For example, the force receiving element used may be a helical spring compressible in its axial direction. Upon activation of the release button, the pre-stressed force-receiving member energizes and moves the cartridge holder in the axial direction of the housing, i.e., in the direction of the spray device. The performance of the force-receiving element determines the energy that can be applied to the formulation and thus the fluid pressure of the formulation that is actually available. The fluid pressure ranges from 100 bar to 700 bar, preferably from 200 bar to 500 bar.

The first and second secondary objects of the present invention are achieved by a cartridge having a first cartridge chamber in which a first liquid is stored and a second cartridge chamber in which a second liquid is stored, the second cartridge chamber being spatially separated from the first cartridge chamber. In this case, the two liquids are placed in one cartridge, whereby the insertion of the cartridge can be simplified.

Preferably, the cartridge has a peripheral wall, a lid wall and a bottom wall that are dimensionally stable.

A further secondary object is achieved by means of a system in which a first liquid is stored in a first cartridge or cartridge chamber, a second liquid is stored in a second cartridge or cartridge chamber, which is spatially separated from the first cartridge or cartridge chamber, a first hollow plunger can be inserted into the first cartridge or cartridge chamber and a second hollow plunger can be inserted into the second cartridge, or a first plunger part connected to the hollow plunger can be inserted into the first cartridge or first cartridge chamber and a second plunger part can be inserted into the second cartridge or second cartridge chamber.

Drawings

For a more complete understanding of the present invention, reference is now made to the following descriptions taken in conjunction with the accompanying drawings. In the drawings:

FIG. 1 is a longitudinal cross-sectional view of a first embodiment of a sprayer having two drug solution cartridge chambers in a drug solution cartridge, the sprayer having two nozzles and two channels extending in parallel relationship with an internally guided hollow plunger;

FIG. 2 is a view corresponding to FIG. 1 of a second embodiment with a nozzle body and two channels extending in parallel relationship with an internally guided hollow plunger;

FIG. 3 is a view corresponding to FIG. 1 of a third embodiment having a nozzle body and a mixing passage in which first and second passages meet;

FIG. 4 is a partial view corresponding to FIG. 1 of a fourth embodiment in which a nozzle body and an impingement chamber are provided in which the first and second passages intersect;

FIG. 5 is a view corresponding to FIG. 1 of a fifth embodiment having a nozzle body and a hollow plunger branched into plunger portions;

FIG. 6 is a longitudinal cross-sectional view of a medical fluid cartridge having first and second medical fluid cartridge chambers.

Like parts in the drawings are denoted by like reference numerals.

Detailed Description

Fig. 1 is a longitudinal sectional view of a first embodiment of a nebulizer 1 having a first nozzle body 8a, a second nozzle body 8b and two channels 9a and 9b extending in parallel relationship with hollow plungers 10a, 10b guided therein. The channels 9a, 9b and the hollow plungers 10a, 10b together form a connecting tube system 7.

The sprayer comprises a housing 3 which is divided into two parts which are rotatable relative to each other, whereby the force-receiving element 23 is compressible. Once the release button 24 is activated, the cup-shaped thrust plate 27 is released and pushed forward in the flow direction 15 (see fig. 2) by means of the spring force of the force-receiving element 23. In this case, two hollow plungers 10a, 10b fixed to the thrust plate 27 and penetrating the thrust plate are also pushed forward together with the thrust plate 27, thus compressing the liquid previously sucked into the passages 9a, 9b and then causing the liquid to flow out from the first nozzle body 8a and the second nozzle body 8 b. By means of separate nozzle outlets 11a provided in the nozzle bodies 8a, 8b₁、11a₂、11b₁、11b₂I.e. all four nozzle outlets form two separate cyclone-like clouds.

For reuse, the force receiving member 23 may be tightened again, thereby moving the thrust plate 27 and the hollow plungers 10a, 10b downward. As the hollow plungers 10a, 10b move downward, each formulation is drawn out of the medical fluid chambers 2a, 2 and flows into the respective first and second passages 9a, 9 b. During this downward movement, the two valve bodies 21a, 21b are in the fluid transfer position.

Upon activation of the release button 24, the hollow plungers 10a, 10b are displaced in the axial direction 25 of the housing 3, i.e. they move upwards. In this case, each valve body 21a, 21b automatically closes the first hollow plunger 10a or the second hollow plunger 10b, thereby compressing the liquid. The valve bodies 21a, 21b are disposed at the rear end 22 of the respective hollow plungers 10a, 10b (see fig. 2).

During the upward movement of the first hollow plunger 10a and the second hollow plunger 10b, the patient can hold his mouth around the connection port 5 provided on the housing 3 and can inhale the aerosol. The connecting port 5 can be covered with a closure cap 26.

In the embodiment shown in fig. 1, each channel 9a, 9b has its own respective nozzle body 8a, 8 b. For the passage of the respective liquid, the nozzle bodies 8a, 8b have two nozzle outlets 11a on the first nozzle body 8a₁、11a₂On the second nozzle body 8b, two further nozzle outlets 11b are provided₁、11b₂. The nozzle outlet 11b of the second nozzle body 8b₁、11b₂Oriented so as to exit the nozzle 11b₁、11b₂The liquid streams ejected in the ejection direction 12 meet at an impingement spacing 14. Likewise, it is applicable to the nozzle outlet 11a from the first nozzle body 8a₁、11a₂The liquid that flows out. Two separate cyclone-like clouds mixed with each other can thereby be prepared.

Nozzle outlet 11a of the first nozzle body 8a₁、11a₂Such as the nozzle outlet 11b of the second nozzle body 8b₁、11b₂As well as being spaced a distance 14a relative to each other, respectively.

Fig. 2 shows a second embodiment of the nebulizer, wherein the channels 9a, 9b in the region of the nebulizing means 6 extend in a common nozzle body 8 and dispense the medicament from the common nozzle body by means of separate individual first and second individual nozzle outlets 11a, 11 b.

As can be seen from fig. 2, the liquids flow out in the injection direction 12 and merge in front of the atomizer 1. Where the liquids meet at an impingement angle 13. In this embodiment, a cyclonic cloud can be prepared from the two liquids because of the confluence of the formulations, especially the excellent atomization and mixing of the formulations.

Fig. 3 shows a third embodiment of the invention, in which the channel 9 is in the form of a mixing channel 16, in other words the first channel 9a and the second channel 9b are combined in the mixing channel 16. Hollow plungers 10a, 10b are mounted in a displaceable manner in one of the channels 9a and 9b, respectively.

In the embodiment shown in fig. 3, mixing of the two liquids occurs during inhalation, i.e. as soon as the two hollow plungers 10a, 10b move downwards.

When the hollow plungers 10a, 10b are moved upwards, the preparation which has been sucked in advance and is present in the channels 9a, 9b, respectively, is compressed and discharged in the direction of the nozzle body 8. The nozzle outlet 11a is visible in the view shown in fig. 3. In the present embodiment, the formulation sucked in from the first medical fluid cylinder chamber 2a by means of the hollow plunger 10a and the formulation sucked in from the second medical fluid cylinder chamber 2b by means of the hollow plunger 10b may be mixed in the mixing passage 16. The valve 12 prevents backflow from the mixing passage 16 back into the medical fluid cartridge chamber.

Fig. 4 shows a fourth embodiment of the invention with a plenum chamber 17 placed in the nozzle body 8, which can replace the mixing channel 16 seen in fig. 3. The channels 9a, 9b terminate in a plenum 17 for mixing of the formulation once the hollow column base is moved upwards. The difference with the embodiment shown in fig. 3 is that the mixing of the liquids does not take place when the liquid is sucked but when the liquid is discharged.

Fig. 5 shows a fifth alternative embodiment, in which a hollow plunger 10 is mounted displaceably in the passage 9. The single channel 9 ends in the flow direction 15 in the nozzle body 8, through which the solution mixture flows out by means of the nozzle outlets 11a, 11 b. Only the first nozzle outlet 11a is visible in the view of fig. 5. Outside the plunger 9, in the region of the end 18 of the hollow plunger 10 adjacent to the cartridge holder, the hollow plunger 10 branches into a first plunger part 19 and a second plunger part 20. In this case, both plunger portions 19, 20 extend into the cartridge holder 4.

The difference from those embodiments described above is that two physically separate cartridges, namely a first cartridge 55 and a second cartridge 56, are disposed in cartridge holder 4. This embodiment is not a preferred embodiment.

Fig. 6 shows a drug solution cartridge 2 of the present invention having a cylindrical drug solution cartridge chamber 2a and a drug solution cartridge 2b which is also cylindrical and is disposed on the side of the drug solution cartridge chamber 2 a.

The two chemical liquid cylinder chambers 2a and 2b have inner walls 57 and 58 spaced from the peripheral wall 50 and the bottom wall 52, respectively. The cover wall 51 is penetrable by an insertion assisting portion 59 engaged with the hollow plungers 10a, 10b, and is insertable into the first medical fluid cylinder chamber 2a and the second medical fluid cylinder chamber 2b after penetrating the closure septum 51 a.

Description of the reference numerals

1 sprayer

2 liquid medicine cylinder

2a first medical solution cylinder chamber

2b second medical solution cylinder chamber

3 outer cover

4 medicine liquid cylinder fixer

5 connecting port

6 spraying device

7 connecting pipe system

8 nozzle body

8a first nozzle body

8b second nozzle body

9 channel

9a first channel

9b second channel

10 hollow plunger

10a first hollow plunger

10b second hollow plunger

11a first nozzle outlet of the nozzle body

11b second nozzle outlet of nozzle body

11a₁A first nozzle outlet of the first nozzle body

11a₂Second nozzle outlet of first nozzle body

11b₁First nozzle outlet of second nozzle body

11b₂Second nozzle outlet of second nozzle body

12 jetting direction

13 angle of impact

14 impact distance

14a spacing of some nozzle outlets of the nozzle body

15 direction of flow

16 mixing channel

17 plenum chamber

18 adjacent the end of the hollow plunger (10) of the cartridge holder

19 first plunger part

20 second plunger part

21 valve body

21a first valve body

21b second valve body

22 rear end of hollow plunger

23 stressed element

24 Release button

25 axial direction of the housing (3)

26 closure cap

27 thrust plate

Peripheral wall of 50 medicine liquid cylinder

51 medicine liquid cylinder cover wall

51a closure diaphragm

52 bottom wall of liquid medicine barrel

55 first liquid medicine barrel

56 second liquid medicine cylinder

57 inner wall of first cartridge

58 inner wall of the second cartridge

59 insertion aid

Claims (21)

1. A nebulizer for dispensing a medical liquid from at least one cartridge (2, 55, 56) mounted in the nebulizer (1), the nebulizer comprising:

a liquid medicine cylinder fixer (4) arranged in the shell (3),

a connection port (5) provided on the housing (3) and having a spraying device (6) therein, and

a connecting tube system (7) connecting the spraying device (6) with the cartridge holder (4), wherein the spraying device (6) has at least one nozzle body (8), the connecting tube system (7) has at least one channel (9) in which a displaceable hollow plunger (10) is arranged, wherein the hollow plunger (10) comprises a valve body (21),

it is characterized in that the preparation method is characterized in that,

a first hollow plunger (10a) is displaceably mounted in the first channel (9a) and a second hollow plunger (10b) is displaceably mounted in the second channel (9b), wherein the first hollow plunger (10a) and the second hollow plunger (10b) extend into the cartridge holder (4).

2. A nebulizer as claimed in claim 1, characterised in that the nebulizing means (6) comprises a first nozzle body (8a) with at least one first nozzle outlet (11a), and a second nozzle body (8b) with at least one second nozzle outlet (11b), wherein the first nozzle body (8a) is connected to the first channel (9a) and the second nozzle body (8b) is connected to the second channel (9 b).

3. A nebulizer as claimed in claim 2, characterised in that the first nozzle outlet (11a) of the first nozzle body (8a) and the second nozzle outlet (11b) of the second nozzle body (8b) are inclined to each other.

4. Nebulizer according to claim 2, characterized in that the first nozzle body (8a) has two nozzle outlets (11a)₁、11a₂) The second nozzle body (8b) having two nozzle outlets (11b)₁、11b₂) Wherein the two nozzle outlets (11a) of the nozzle bodies (8a, 8b)₁、11a₂；11b₁、11b₂) Are inclined to each other.

5. A nebulizer as claimed in claim 1, characterised in that the nebulizing device (6) has a nozzle body (8), wherein the first and second channels (9a, 9b) are guided into the nozzle body and each channel is provided with a first and second nozzle outlet (11a, 11 b).

6. Nebulizer according to claim 1, characterized in that the nebulizing device (6) comprises a nozzle body (8), in front of which nozzle body (8) in the flow direction (15) a mixing channel (16) is provided, in which the first and second channel (9a, 9b) meet.

7. A nebulizer as claimed in claim 1, characterised in that the nebulizing means (6) has a nozzle body (8) inside which a plenum chamber (17) is provided, in which the first and second channels (9a, 9b) meet.

8. A nebulizer for dispensing a medical liquid from at least one cartridge (2, 55, 56) mounted in the nebulizer (1), the nebulizer comprising:

a liquid medicine cylinder fixer (4) arranged in the shell (3),

a connection port (5) provided on the housing (3) and having a spraying device (6) therein, and

a connecting tube system (7) connecting the spraying device (6) with the cartridge holder (4), wherein the spraying device (6) has at least one nozzle body (8), the connecting tube system (7) has at least one channel (9) in which a displaceable hollow plunger (10) is arranged, wherein the hollow plunger (10) comprises a valve body (21),

it is characterized in that the preparation method is characterized in that,

the at least one hollow plunger (10) is branched into a first and a second plunger part (19, 20) at its end (18) adjacent to the cartridge holder, wherein the first and second plunger parts (19, 20) protrude into the cartridge holder (4).

9. A nebulizer as claimed in any one of claims 6 to 8, characterised in that the one nozzle body (8) has first and second nozzle outlets (11a, 11 b).

10. A nebulizer as claimed in claim 5 or 9, characterised in that the first nozzle outlet (11a) and second nozzle outlet (11b) of the common nozzle body (8) are inclined to each other.

11. Nebulizer according to claim 3, 4 or 10, characterized in that the inclined nozzle outlet (11a, 11 b; 11a)₁、11a₂；11b₁、11b₂) Are oriented such that they form a liquid injection direction with an impact angle of preferably 20 ° to 160 °, more preferably 60 ° to 150 °, most preferably 80 ° to 100 °.

12. A nebulizer according to any one of claims 4, 5 or 9 to 11, characterised in that the nozzle outlet (11a, 11 b; 11a) is provided at a distance (14a) of 10 to 200 micrometres, preferably 10 to 100 micrometres, more preferably 30 to 70 micrometres, even more preferably 50 micrometres, over the nozzle body (8, 8a, 8b)₁、11a₂；11b₁、11b₂)。

13. Nebulizer according to one of claims 1 to 12, characterized in that the valve body (21) is arranged at an end (22) of the hollow plunger (10, 10a, 10b), which end is the downstream end in the flow direction (15).

14. A nebulizer as claimed in any one of claims 1 to 13, characterised in that the at least one nozzle body (8, 8a, 8b) is fixed in position to the at least one passage (9, 9a, 9 b).

15. Nebulizer according to any one of claims 1 to 14, characterized in that the cartridge holder (4) is movably mounted.

16. Nebulizer according to one of claims 1 to 15, characterized in that a force element (23) is provided in the housing (3) to store a predetermined amount of energy.

17. A nebulizer as claimed in claim 16, wherein the force-receiving element (23) provides the energy and moves the cartridge holder (4) in the axial direction (25) of the housing (3) upon actuation of a release button (24).

18. A nebulizer as claimed in claim 16 or 17, characterised in that the force element (23) moves the cartridge holder (4) in the direction of the nebulizing means (6).

19. A cartridge, preferably for mounting in a nebulizer (1) as claimed in one of claims 1 to 16, characterized in that the cartridge (2) has a first and a second cartridge chamber (2a, 2b), wherein the first liquid is stored in the first cartridge chamber (2a) and the second liquid is stored in the second cartridge chamber (2b) which is spatially separated from the first cartridge chamber (2 a).

20. The cartridge according to claim 19, wherein the cartridge (2) has a peripheral wall (50), a lid wall (51) and a bottom wall (52) of a stable shape.

21. A system comprising a nebulizer (1) for dispensing a medical liquid and at least one cartridge (2, 55, 56) disposable in the nebulizer (1), wherein the nebulizer (1) comprises:

a liquid medicine cylinder fixer (4) arranged in the shell (3),

a connection port (5) provided on the housing (3) and having a spraying device (6) therein, and

a connecting tube system (7) connecting the spraying device (6) with the cartridge holder (4), wherein the spraying device (6) has at least one nozzle body (8), the connecting tube system (7) has at least one channel (9) in which a displaceable hollow plunger (10) is arranged, wherein the hollow plunger (10) comprises a valve body (21),

it is characterized in that the preparation method is characterized in that,

a first liquid is stored in a first cartridge (55) or a cartridge chamber (2a), a second liquid is stored in a second cartridge (56) or a cartridge chamber (2b) spatially separated from the first cartridge (55) or the cartridge chamber (2a), and

a first hollow plunger (10a) may be inserted into the first cartridge (55) or the cartridge chamber (2a), a second hollow plunger (10b) may be inserted into the second cartridge (56), or a first plunger portion (19) connected to the hollow plunger (10) may be inserted into the first cartridge (55) or the first cartridge chamber (2a), and a second plunger portion (20) may be inserted into the second cartridge (56) or the second cartridge chamber (2 b).