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HK1178171B - 2-(((s)-(((2r，3r，4r，5r)-5-(2，4-二氧代-3，4-二氢嘧啶-1(2h)-基)-4-氟代-3-羟基-4-甲基四氢呋喃-2-基)甲氧基)(苯氧基)磷酰基)氨基)丙酸(s)-异丙酯 - Google Patents

2-(((s)-(((2r，3r，4r，5r)-5-(2，4-二氧代-3，4-二氢嘧啶-1(2h)-基)-4-氟代-3-羟基-4-甲基四氢呋喃-2-基)甲氧基)(苯氧基)磷酰基)氨基)丙酸(s)-异丙酯 Download PDF

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Publication number
HK1178171B
HK1178171B HK13105092.1A HK13105092A HK1178171B HK 1178171 B HK1178171 B HK 1178171B HK 13105092 A HK13105092 A HK 13105092A HK 1178171 B HK1178171 B HK 1178171B
Authority
HK
Hong Kong
Prior art keywords
phenoxy
mixture
isopropyl
crystalline
fluoro
Prior art date
Application number
HK13105092.1A
Other languages
German (de)
English (en)
French (fr)
Other versions
HK1178171A1 (zh
Inventor
Bruce S. Ross
Michael Joseph Sofia
Ganapati Reddy Pamulapati
Suguna Rachakonda
Hai-Ren Zhang
Byoung-Kwon Chun
Peiyuan Wang
Original Assignee
Gilead Pharmasset Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/783,680 external-priority patent/US8642756B2/en
Application filed by Gilead Pharmasset Llc filed Critical Gilead Pharmasset Llc
Priority claimed from PCT/US2011/030725 external-priority patent/WO2011123645A2/en
Publication of HK1178171A1 publication Critical patent/HK1178171A1/zh
Publication of HK1178171B publication Critical patent/HK1178171B/zh

Links

HK13105092.1A 2010-03-31 2011-03-31 2-(((s)-(((2r，3r，4r，5r)-5-(2，4-二氧代-3，4-二氢嘧啶-1(2h)-基)-4-氟代-3-羟基-4-甲基四氢呋喃-2-基)甲氧基)(苯氧基)磷酰基)氨基)丙酸(s)-异丙酯 HK1178171B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31954810P 2010-03-31 2010-03-31
US31951310P 2010-03-31 2010-03-31
US319548P 2010-03-31
US319513P 2010-03-31
US783680 2010-05-20
US12/783,680 US8642756B2 (en) 2009-05-20 2010-05-20 Nucleoside phosphoramidates
PCT/US2011/030725 WO2011123645A2 (en) 2010-03-31 2011-03-31 Nucleoside phosphoramidates

Publications (2)

Publication Number Publication Date
HK1178171A1 HK1178171A1 (zh) 2013-09-06
HK1178171B true HK1178171B (zh) 2016-04-01

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