HK1156868B - Oil in water emulsion cosmetic material for skin - Google Patents

Description

Oil-in-water emulsion skin cosmetic

Technical Field

The present invention relates to an oil-in-water type emulsion skin cosmetic. More specifically, the present invention relates to an oil-in-water type emulsion skin cosmetic composition containing a stable amount of vitamins a, having excellent usability (skin compatibility, feeling of effect after application) and excellent stability with time (emulsion stability) of a base, particularly cream.

Background

Vitamin a compounds (retinoids) represented by vitamin a, vitamin a acetate, and the like have been known as effective ingredients for preventing or treating keratosis and the like, preventing or recovering skin aging, and the like, and have been blended as effective ingredients in external preparations for skin.

However, retinoids are unstable and easily deteriorate under the influence of light, air, heat, metal ions, and the like. Therefore, the skin external preparation containing such vitamin a has a problem in stability with time. In order to solve these problems, a technique of blending an oil-soluble antioxidant or the like has been reported. For example, japanese patent laying-open No. 11-228377 (patent document 1) discloses an oil-in-water emulsion composition containing a vitamin a fatty acid ester, an oil-soluble antioxidant, an amphiphilic substance, and a hydrophilic nonionic surfactant at a predetermined mixing ratio. Further, Japanese patent application laid-open No. 2005-104962 (patent document 2) discloses an external preparation for skin containing vitamins and/or derivatives thereof, a drug having a peroxide removal rate of 75% or more, and an oil-soluble antioxidant.

However, the invention described in patent document 1 has no study on usability (skin-friendly property, feeling of effect after application), although it exerts an excellent effect on stable incorporation of vitamins a. Patent document 2 also does not describe any usability effect.

In addition, Japanese patent application laid-open No. 2005-320263 (patent document 3) shows that it is desired to obtain an oil-in-water type emulsion skin cosmetic, particularly cream type emulsion skin cosmetic, having a pleasant feeling, a penetrating feeling, and the like in use, but this publication does not describe or suggest a stable preservation of vitamin A type.

Documents of the prior art

Patent document

Patent document 1: japanese laid-open patent publication No. 11-228377

Patent document 2: japanese patent laid-open publication No. 2005-104962

Patent document 3: japanese patent laid-open publication No. 2005-320263

Disclosure of Invention

Problems to be solved by the invention

The present invention has been made in view of the above circumstances, and an object thereof is to provide an oil-in-water type emulsion skin cosmetic which contains a vitamin a compound stably and has excellent usability (skin-friendly property, feeling of effect after application) and excellent stability with time (emulsion stability) of a base.

Means for solving the problems

In order to solve the above problems, the present invention provides an oil-in-water emulsion skin cosmetic comprising, based on the total amount of the cosmetic:

0.01 to 4 mass% of (a) vitamin A and a derivative thereof;

0.6 to 4% by mass of (b) a nonionic surfactant comprising the following components (b-1) to (b-3),

(b-1) sorbitan tristearate,

(b-2) polyethylene glycol stearate having an addition mole number of 20 to 120 of polyethylene glycol,

(b-3) glyceryl stearate with HLB of 5-8; and

1 to 10 mass% of (c) a higher alcohol having 14 to 24 carbon atoms;

the mixing ratio (mass ratio) of the component (b-1) to the component (b) is 0.1 to 0.8.

ADVANTAGEOUS EFFECTS OF INVENTION

The oil-in-water emulsion skin cosmetic composition of the present invention is stable in the incorporation of vitamins a, and is excellent in usability (skin-friendly properties, feeling of effect after application) and stability with time (emulsion stability) of a base.

Detailed Description

The present invention will be described in detail below.

Examples of the vitamin a and its derivative as the component (a) include vitamin a (═ retinol), vitamin a aldehyde (═ retinal), vitamin a acid (═ retinoic acid), vitamin a fatty acid esters, and salts thereof. Examples of the vitamin a fatty acid ester include vitamin a acetate (retinol acetate), vitamin a palmitate (retinol palmitate), vitamin a propionate (retinol propionate), and vitamin a linoleate (retinol linoleate). Examples of the salt include alkali metal salts (e.g., sodium salt, potassium salt, lithium salt, etc.), alkaline earth metal salts (e.g., calcium salt, magnesium salt, etc.), ammonium salts, organic amine salts (e.g., monoethanolamine salt, diethanolamine salt, triethanolamine salt, etc.), and the like. In the present invention, from the viewpoint of stability, effectiveness, and the like, a vitamin a fatty acid ester and a salt thereof are particularly preferably used as the component (a). (a) The components can be 1 or more than 2.

The amount of the component (a) blended in the oil-in-water emulsion skin cosmetic composition of the present invention is 0.01 to 4% by mass, preferably 0.1 to 0.5% by mass. When the content is less than 0.01% by mass, the drug effect as the component (a) cannot be sufficiently exhibited, while when the content exceeds 4% by mass, excessive irritation may be caused to the skin.

(b) The component (A) is a nonionic surfactant, and 3 kinds of the following components (b-1), (b-2) and (b-3) are essential components in the present invention.

The component (b-1) is sorbitan tristearate. HLB2.1, lipophilic.

The component (b-2) is polyethylene glycol stearate with the addition mole number of 20-120 of polyethylene glycol. Specific examples include polyethylene glycol monostearate (20 mol polyethylene glycol adduct, also referred to as 20EO or 20 pg), polyethylene glycol monostearate (25EO), polyethylene glycol monostearate (30EO), polyethylene glycol monostearate (40EO), polyethylene glycol monostearate (45EO), polyethylene glycol monostearate (55EO) and polyethylene glycol monostearate (100EO), but the examples are not limited thereto. Among them, polyethylene glycol monostearate (40EO), polyethylene glycol monostearate (45EO), polyethylene glycol monostearate (55EO), and the like are preferably used from the viewpoint of usability and the like. The component (b-2) may be used in 1 type or 2 or more types.

The component (b-3) is glyceryl stearate with HLB of 5-8. The component (b-3) is obtained by mixing an arbitrary higher fatty acid with glyceryl stearate to adjust HLB to 5 to 8. Also disclosed is a self-emulsifying substance obtained by adding a soap and/or a nonionic surfactant to glyceryl stearate. Specific examples thereof include glyceryl stearate (HLB5), self-emulsifying glyceryl stearate (HLB5), self-emulsifying glyceryl stearate (HLB6), self-emulsifying glyceryl stearate (HLB7), glyceryl isostearate (HLB6), glyceryl diisostearate (HLB3), and the like. The component (b-3) may be used in 1 type or 2 or more types.

Further, HLB is calculated by the above formula shown in the following numerical formula 1.

Mathematical formula 1

HLB＝7+11.7log(MW/MO)

(wherein MW represents the molecular weight of the hydrophilic moiety and MO represents the molecular weight of the lipophilic moiety)

The amount of the component (b) blended in the oil-in-water emulsion skin cosmetic composition of the present invention is 0.6 to 4% by mass, preferably 1 to 3% by mass. When the amount is less than 0.6% by mass, a sufficient emulsifying power cannot be secured and the stability of the base agent with time is poor, while when it exceeds 4% by mass, the component (a) cannot be stably blended.

In the present invention, the blending ratio (mass ratio) of the component (b-1) to the total amount of the component (b) is 0.1 to 0.8 as component (b-1)/component (b). If the blending ratio of component (b-1)/component (b) deviates from the above range, the stable blending effect of component (a) cannot be obtained.

(c) The component is a higher alcohol having 14 to 24 carbon atoms, preferably 16 to 22 carbon atoms. Specific examples thereof include linear alcohols such as cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, and cetostearyl alcohol; and branched alcohols such as monostearyl glyceryl ether (batyl alcohol), 2-decyltetradecylenol, lanolin alcohol, hexyldodecanol, isostearyl alcohol, and octyldodecanol. Among them, stearyl alcohol and behenyl alcohol are preferably used. (c) The components can be 1 or more than 2.

The amount of the component (c) blended in the oil-in-water emulsion skin cosmetic composition of the present invention is 1 to 10% by mass, preferably 2 to 5% by mass. When the amount is less than 1% by mass, the base is a cream, separation tends to occur, and the base is less likely to be incorporated in the sense of usability, while when the amount is more than 10% by mass, a sticky feeling is produced, and usability is deteriorated.

The oil-in-water emulsion skin cosmetic of the present invention containing the components (a) to (c) is stably blended with the component (a) and is excellent in usability (skin-blendability, feeling of effect after application) and stability with time (emulsion stability).

The oil-in-water type emulsified skin cosmetic of the present invention can be prepared by a conventional method, and the method of emulsification is not particularly limited. Examples of the method include the following: the oil phase (internal phase) and the aqueous phase (external phase) are heated to about 70 ℃ respectively, the heated oil phase is slowly added to the aqueous phase, the mixture is emulsified by an emulsifier, and then the mixture is cooled to room temperature. The water phase (external phase) is preferably 20 to 80% by mass, more preferably 30 to 60% by mass, based on the total amount of the cosmetic.

Examples of the oil-in-water type emulsified skin cosmetic of the present invention include emulsion products such as emulsified foundation, sunscreen lotion and cosmetic liquid, and cream products such as skin cream, but are not limited thereto.

The oil-in-water emulsion skin cosmetic of the present invention may be appropriately blended with other optional additives generally used in skin external preparations such as cosmetics and pharmaceuticals, for example, powder components, solid oils and fats, waxes, hydrocarbons, higher fatty acids, esters, silicones, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants (other than component (b)), water-soluble polymers, ultraviolet absorbers, metal ion chelating agents, lower alcohols, polyols, sugars, amino acids, organic amines, polymer emulsions, pH regulators, skin nutrients, vitamins, antioxidants, antioxidant aids, perfumes, water, and the like, as necessary, within a range not to impair the effects of the present invention.

Examples of the powder component include inorganic powders (for example, talc, kaolin, mica, sericite (serilite), muscovite, phlogopite, synthetic mica, lepidolite, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate (calcined gypsum), calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, metal soaps (for example, zinc myristate, calcium palmitate, and aluminum stearate), boron nitride, and the like); organic powders (e.g., polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, etc.); inorganic white pigments (e.g., titanium dioxide, zinc oxide, etc.); inorganic red pigments (e.g., iron oxide (red iron oxide), iron titanate, etc.); inorganic brown pigments (e.g., gamma-iron oxide); inorganic yellow pigments (e.g., yellow iron oxide, yellow soil, etc.); inorganic black pigments (e.g., black iron oxide, low-dimensional titanium oxide, etc.); inorganic violet pigments (e.g., manganese violet and cobalt violet); inorganic green pigments (e.g., chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (e.g., ultramarine blue and berlin blue); pearlescent pigments (e.g., titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, colored titanium oxide-coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (e.g., aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium, or aluminum lakes (e.g., organic pigments such as red 201, red 202, red 204, red 205, red 220, red 226, red 228, red 405, orange 203, orange 204, yellow 205, yellow 401, and blue 404, organic pigments such as red 3, red 104, red 106, red 227, red 230, red 401, red 505, orange 205, yellow 4, yellow 5, yellow 202, yellow 203, green 3, and blue 1); natural pigments (e.g., chlorophyll, beta-carotene, etc.), and the like.

Examples of the solid fat and oil include cacao butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, mutton tallow, hydrogenated beef tallow, palm kernel oil, lard, beef bone fat, beeswax kernel oil, hydrogenated oil, beef foot fat, beeswax, hydrogenated castor oil, and the like.

Examples of the waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, white wax, spermaceti, montan wax, rice bran wax, lanolin, kapok wax, acetylated lanolin, liquid lanolin, sugar cane wax, isopropyl lanolate, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, and POE hydrogenated lanolin alcohol ether.

Examples of the higher fatty acid include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, tall acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

Examples of the anionic surfactant include fatty acid soaps (e.g., sodium laurate, sodium palmitate, etc.); higher alkyl sulfate ester salts (e.g., sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfate ester salts (e.g., POE-triethanolamine lauryl sulfate, POE-sodium lauryl sulfate, etc.); n-acyl sarcosines (e.g., sodium lauroyl sarcosinate, etc.); higher fatty acid amide sulfonates (e.g., sodium N-myristoyl-N-methyltaurate, sodium coconut fatty acid methyltaurate, sodium lauryl methyltaurate, etc.); phosphate ester salts (POE-sodium oleyl ether phosphate, POE-stearyl ether phosphate, etc.); sulfosuccinates (e.g., sodium di-2-ethylhexyl sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, and the like); alkyl benzene sulfonates (e.g., linear sodium dodecylbenzene sulfonate, linear triethanolamine dodecylbenzene sulfonate, linear dodecylbenzene sulfonic acid, etc.); higher fatty acid ester sulfate salts (e.g., sodium hydrogenated coconut oil fatty acid glycerol sulfate); n-acyl glutamates (e.g., monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, monosodium N-myristoyl-L-glutamate, etc.); sulfated oils (e.g., turkish red oil, etc.); POE-alkyl ether carboxylic acids; POE-alkyl allyl ether carboxylate; an alpha-olefin sulfonate; higher fatty acid ester sulfonates; secondary alcohol sulfate salts; higher fatty acid alkylolamide sulfate salts; lauroyl monoethanolamide sodium succinate; n-palmitoyl aspartic acid ditriethanolamine; sodium caseinate, and the like.

Examples of the cationic surfactant include alkyltrimethylammonium salts (e.g., stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (e.g., cetyl pyridinium chloride, etc.); distearyldimethylammonium chloride, dialkyldimethylammonium salts; poly (N, N' -dimethyl-3, 5-methylenepiperidinium) chloride; alkyl quaternary ammonium salts; alkyl dimethyl benzyl ammonium salts; an alkylisoquinolinium salt; a dialkyl morpholinium salt; POE-alkylamine; an alkylamine salt; polyamine fatty acid derivatives; a pentanol fatty acid derivative; benzalkonium chloride; benzethonium chloride, and the like.

Examples of the amphoteric surfactant include imidazoline amphoteric surfactants (e.g., 2-undecyl-N, N, N- (hydroxyethyl carboxymethyl) -2-imidazolinium sodium, 2-coco-2-imidazolinium hydroxide-1-carboxyethoxy disodium salt, etc.); betaine-type surfactants (e.g., 2-heptadecyl-N-carboxymethyl-N-hydroxyethyl imidazoline betaine, lauryl dimethylamino acetate betaine, alkyl betaine, amido betaine, sulfobetaine, etc.), and the like.

Examples of the lipophilic nonionic surfactant include sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexanoate, diglycerol sorbitan tetra-2-ethylhexanoate, etc.); glycerol polyglycerin fatty acids (e.g., cottonseed oil fatty acid glyceride, erucic acid glyceride, glyceryl sesquioleate, glyceryl monostearate, α' -oleic acid pyroglutamic acid glyceride, glyceryl monostearate malate, etc.); propylene glycol fatty acid esters (e.g., propylene glycol monostearate); hydrogenated castor oil derivatives; glycerol alkyl ethers, and the like.

Examples of the hydrophilic nonionic surfactant include POE-sorbitan fatty acid esters (e.g., POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, and POE-sorbitan tetraoleate); POE sorbitol fatty acid esters (e.g., POE-sorbitol monolaurate, POE-sorbitol monooleate, POE-sorbitol pentaoleate, POE-sorbitol monostearate, etc.); POE-glycerin fatty acid esters (for example, POE-monooleate such as POE-glycerin monostearate, POE-glycerin monoisostearate and POE-glycerin triisostearate); POE-fatty acid esters (e.g., POE-distearate, POE-monooleate, ethylene glycol distearate, etc.); POE-alkyl ethers (e.g., POE-lauryl ether, POE-oleyl ether, POE-stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE-cholestanol ether, etc.); pluronic types (e.g., Pluronic, etc.); POE/POP-alkyl ethers (e.g., POE/POP-cetyl ether, POE/POP-2-decyltetradecyl ether, POE/POP-monobutyl ether, POE/POP-hydrogenated lanolin, POE/POP-glyceryl ether, etc.); tetrapolye/tetrapod-ethylenediamine condensates (for example, Tetronic); POE-castor oil hydrogenated castor oil derivatives (e.g., POE-castor oil, POE-hydrogenated castor oil monoisostearate, POE-hydrogenated castor oil triisostearate, POE-hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, POE-hydrogenated castor oil maleic acid, etc.); POE-beeswax/lanolin derivatives (e.g., POE-sorbitol beeswax, etc.); alkanolamides (e.g., coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE-propylene glycol fatty acid ester; POE-alkylamine; POE-fatty acid amide; sucrose fatty acid ester; alkyl ethoxy dimethyl amine oxide; triolein phosphoric acid and the like.

Examples of the natural water-soluble polymer include plant-based polymers (e.g., acacia, tragacanth gum, galactose, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (marmelo), seaweed colloid (seaweed extract), starch (rice, corn, potato, wheat), and glycyrrhizic acid); microbial polymers (e.g., xanthan gum, dextran, succinoglucan, pullulan, etc.); animal polymers (e.g., collagen, casein, albumin, gelatin, etc.), and the like.

Examples of the semisynthetic water-soluble polymer include starch-based polymers (e.g., carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose polymers (methyl cellulose, ethyl cellulose, methylhydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder, etc.); alginic acid polymers (e.g., sodium alginate, propylene glycol alginate, etc.), and the like.

Examples of the water-soluble polymer to be synthesized include vinyl polymers (e.g., polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer, etc.); polyoxyethylene polymers (e.g., polyoxyethylene polyoxypropylene copolymers of polyethylene glycol 20,000, 40,000, 60,000, etc.); acrylic polymers (for example, sodium polyacrylate, polyethylacrylate, polyacrylamide, etc.); a polyethyleneimine; cationic polymers, and the like.

Examples of the inorganic water-soluble polymer include bentonite, magnesium aluminum silicate (Veegum), laponite, hectorite, and silicic anhydride.

Examples of the ultraviolet absorber include benzoic acid-based ultraviolet absorbers (for example, p-aminobenzoic acid (hereinafter, abbreviated as PABA), PABA monoglyceride, N-dipropoxyppaba ethyl ester, N-diethoxyppaba ethyl ester, N-dimethylppaba butyl ester, N-dimethylppaba ethyl ester, and the like); anthranilic acid-based ultraviolet absorbers (e.g., trimethylcyclohexyl (homomenthyl) -N-acetyl anthranilate); salicylic acid-based ultraviolet absorbers (e.g., amyl salicylate, menthyl salicylate, trimethylcyclohexyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanolphenyl salicylate, etc.); cinnamic acid-based ultraviolet absorbers (for example, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2, 5-diisopropyl cinnamate, ethyl-2, 4-diisopropyl cinnamate, methyl-2, 4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isopentyl-p-methoxy cinnamate, octyl-p-methoxy cinnamate (2-ethylhexyl-p-methoxy cinnamate), 2-ethoxyethyl-p-methoxy cinnamate, cyclohexyl-p-methoxy cinnamate, ethyl- α -cyano- β -phenyl cinnamate, 2-ethylhexyl- α -cyano- β -phenyl cinnamate, methyl-2, 5-diisopropyl cinnamate, isopropyl-p-methoxy cinnamate, isopentyl-p-methoxy cinnamate, octyl-p-methoxy cinnamate, 2-ethylhexyl-p-methoxy cinnamate, cyclohexyl-p-, Glyceryl mono-2-ethylhexanoyl-di-p-methoxycinnamate, etc.); benzophenone-based ultraviolet absorbers (e.g., 2, 4-dihydroxybenzophenone, 2 ' -dihydroxy-4-methoxybenzophenone, 2 ' -dihydroxy-4, 4 ' -dimethoxybenzophenone, 2 ', 4, 4 ' -tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4 ' -methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4 ' -phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octyloxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc.); 3- (4' -methylbenzylidene) -d, 1-camphor, 3-benzylidene-d, 1-camphor; 2-phenyl-5-methylbenzoxazole; 2, 2' -hydroxy-5-methylphenylbenzotriazole; 2- (2 '-hydroxy-5' -tert-octylphenyl) benzotriazole; 2- (2 '-hydroxy-5' -methylphenyl) benzotriazole; dibenzylazine (dibenzazine); a dianisilyl methane; 4-methoxy-4' -tert-butyl dibenzoylmethane; 5- (3, 3-dimethyl-2-norbornenyl) -3-pentan-2-one, and the like.

Examples of the metal ion chelating agent include 1-hydroxyethane-1, 1-bisphosphonic acid, 1-hydroxyethane-1, 1-bisphosphonic acid tetrasodium salt, ethylenediaminetetraacetic acid disodium salt, ethylenediaminetetraacetic acid trisodium salt, ethylenediaminetetraacetic acid tetrasodium salt, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, ethylenediaminetetraacetic acid, ethylenediaminehydroxyethyltriacetic acid trisodium salt, and the like.

Examples of the lower alcohol include ethanol, propanol, isopropanol, isobutanol, and tert-butanol.

Examples of the polyhydric alcohol include dihydric alcohols (e.g., ethylene glycol, propylene glycol, 1, 3-propanediol, 1, 2-butanediol, 1, 3-butanediol, 1, 4-butanediol, 2, 3-butanediol, 1, 5-pentanediol, 2-butene-1, 4-diol, hexanediol, octanediol, etc.); trihydric alcohols (e.g., glycerin, trimethylolpropane, etc.); tetrahydric alcohols (e.g., pentaerythritol such as 1, 2, 6-hexanetriol); pentahydric alcohols (e.g., xylitol, etc.); hexahydric alcohols (e.g., sorbitol, mannitol, etc.); polyol polymers (e.g., diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerol, tetraglycerol, polyglycerin, etc.); glycol alkyl ethers (e.g., ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, etc.); glycol alkyl ethers (e.g., diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol butyl ether, etc.); glycol ether esters (e.g., ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadipate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, etc.); glycerol monoalkyl ethers (e.g., chimyl alcohol, selachyl alcohol, batyl alcohol, etc.); sugar alcohols (e.g., sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, amylolytic sugar, maltose, xylose, amylolytic sugar-reducing alcohol, etc.); glysolid; tetrahydrofurfuryl alcohol; POE-tetrahydrofurfuryl alcohol; POP-butyl ether; POP-POE-butyl ether; glyceryl tripropylene oxide ether; POP-glycerol ether; POP-glyceryl ether phosphoric acid; POP-POE-pentaerythritol ether, polyglycerol, etc.

Examples of the monosaccharide include a three-carbon sugar (e.g., D-glyceraldehyde, dihydroxyacetone, etc.); four carbon sugars (e.g., D-erythrose, D-erythrulose, D-threose, erythritol, etc.); five-carbon sugars (e.g., L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L-xylulose, etc.); six carbon sugar (for example, D-glucose, D-talose, D-psicose, D-galactose, D-fructose, L-galactose, L-mannose, D-tagatose, etc.); hepta-sugars (e.g., aldoheptose, heptose, etc.); eight-carbon sugars (e.g., octulose, etc.); deoxy sugars (e.g., 2-deoxy-D-ribose, 6-deoxy-L-galactose, 6-deoxy-L-mannose, etc.); aminosugars (e.g., D-glucosamine, D-galactosamine, sialic acid, aminouronic acid, muramic acid, etc.); uronic acids (e.g., D-glucuronic acid, D-mannuronic acid, L-guluronic acid, D-galacturonic acid, L-iduronic acid, etc.) and the like.

Examples of oligosaccharides include sucrose, gentiotriose, umbelliferose, lactose, psyllium, isolignins (Isolignose), α -trehalose, raffinose, lignins (Lignose), ulmtilicin, stachyose, and verbascose.

Examples of the polysaccharide include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucopolysaccharide sulfate, guar gum, dextran, keratin sulfate, locust bean gum, succinoglucan, and trichosanthes kirilowii acid.

Examples of the amino acid include neutral amino acids (e.g., threonine and cysteine); basic amino acids (e.g., hydroxylysine, etc.), and the like. Examples of the amino acid derivative include sodium acyl sarcosinate (sodium lauroyl sarcosinate), acyl glutamate, sodium acyl β -alanine, glutathione, pyrrolidone carboxylic acid, and the like.

Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1, 3-propanediol, and 2-amino-2-methyl-1-propanol.

Examples of the polymer latex include acrylic resin latex, polyethylacrylate latex, acrylic resin solution, polyalkylacrylate latex, polyvinyl acetate resin latex, and natural rubber latex.

Examples of the pH adjuster include buffers such as sodium lactate, sodium citrate, and sodium succinate.

Examples of the vitamins include vitamins A, B1, B2, B6, C, E and derivatives thereof, pantothenic acid and derivatives thereof, and biotin.

Examples of the antioxidant include tocopherol, dibutylhydroxytoluene (BHT), Butylhydroxyanisole (BHA), and gallic acid esters.

Examples of the antioxidant auxiliary include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.

Examples of other ingredients that can be blended include preservatives (ethyl p-hydroxybenzoate, butyl p-hydroxybenzoate, etc.); anti-inflammatory agents (e.g., glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol (hinokitiol), zinc oxide, allantoin, etc.); whitening agents (e.g., placenta extract, saxifrage extract, arbutin, etc.); various extracts (e.g., phellodendron amurense, goldthread root, chinese herbaceous peony, swertia japonica, birch (birch), sage, loquat, ginseng, aloe, mallow, iris, grape, coix seed, luffa, lily, saffron, chuanxiong rhizome, ginger, forsythia, formononetin, garlic, capsicum, dried orange peel, angelica, seaweed, etc.), activators (e.g., royal jelly, photosensitizer, cholesterol derivative, etc.); blood circulation-promoting agents (e.g., vanillylamide nonanoate (nonillitylamide)), benzyl nicotinate, β -butoxyethyl nicotinate, capsaicin, zingerone, tincture of cantharides, ichthammol, tannic acid, α -borneol, tocopherol nicotinate, inositol hexanicotinate, cyclamate, cinnamylphenylpiperazine, tolazoline, acetylcholine, verapamil, cepharanthine, γ -oryzanol, etc.); anti-lipemic agents (e.g., sulfur, dithionthracene, etc.); anti-inflammatory agents (e.g., tranexamic acid, thiotaurine, hypotaurine, etc.), and the like.

Examples

The present invention will be described more specifically with reference to the following examples, but the present invention is not limited to these examples at all. Unless otherwise specified, the amounts are mass%.

First, the test method and the evaluation method used in this example will be described.

[ stability of vitamin A fatty acid ester ]

The residual rate of vitamin A fatty acid ester in the sample was used as an evaluation index. That is, the residual rate (%) of the vitamin A fatty acid ester in the sample after storage before storage was determined by storing the sample at 50 ℃ for 1 month in a light-shielded aluminum foil and analyzing the result by high performance liquid chromatography, and this was used as the residual rate (%) of the evaluation index. The survival rate is preferably as close to 100%. The residual rate was evaluated as "good" when 80% or more and "poor" when less than 80% was found.

The high performance liquid chromatography for determining the residual ratio was performed under the following conditions.

Column: c18 column (manufactured by senior of Kabushiki Kaisha)

And (3) detection: UV310nm

Mobile phase: 72% methanol/10% acetonitrile/18% ion-exchanged water/0.5% acetic acid.

[ stability over time (emulsion stability) ]

In the above-described stability evaluation test of a vitamin a fatty acid ester, the appearance was visually observed, and the stability with time (emulsion stability) of each sample after 1 month at 50 ℃ was evaluated according to the following evaluation criteria.

(evaluation criteria)

O: after the base (sample) was produced, no abnormal appearance and no separation occurred even after 1 month (50 ℃ C.).

And (delta): slight separation occurred after 1 month (50 ℃ C.) after the preparation of the base (sample).

X: the emulsifying power was insufficient, and the base (sample) could not be produced.

[ usability (skin-fusibility) ]

Each sample (sample immediately after manufacture) was applied to the face by a professional panelist (10), and the skin fusion property at the time of application was evaluated according to the following evaluation criteria.

(evaluation criteria)

Very good: more than 9 answers showed good skin fusion.

O: the 6-8 answers had good skin fusion.

And (delta): 4-5 answers had good skin fusion.

X: the following 3 responses were good in skin fusion.

[ usability (feeling of effect after coating) ]

Each sample (sample immediately after manufacture) was applied to the face by a professional panelist (10), and the feeling of effect after application was evaluated according to the following evaluation criteria.

(evaluation criteria)

Very good: the 9 above answers felt the effect after coating.

O: 6-8 responses were felt to have the effect after coating.

And (delta): the 4-5 answers experienced the effect after coating.

X: the following 3 answers felt the effect after coating.

Comparative example 1 and examples 1 to 4

The samples shown in table 1 below were prepared, and the stability of retinol acetate, the stability with time of the base (emulsion stability), and the usability (skin-friendly property, feeling of effect after application) were evaluated according to the above evaluation methods. The results are shown in Table 1.

[ Table 1]

As is clear from the results shown in Table 1, in comparative example 1 lacking the component (b-1), the remaining ratio of retinol acetate was less than 80%, and the stability was lost.

(examples 5 to 8, comparative examples 2 to 4)

The samples shown in table 2 below were prepared, and the stability of retinol acetate, the stability with time of the base (emulsion stability), and the usability (skin-friendly property, feeling of effect after application) were evaluated according to the above evaluation methods. The results are shown in Table 2.

[ Table 2]

As is clear from the results shown in Table 2, in comparative example 2 in which the total amount of component (b) is outside the range of the present invention, retinol acetate is insufficient in stability. In comparative examples 3 and 4 in which the total amount of component (b) is less than the range of the present invention, the stability of the base (emulsion stability) with time was poor, and in comparative example 3, a cream-like base was produced and slightly separated after 1 month (50 ℃), and in comparative example 4, a cream-like base could not be produced. In comparative examples 3 and 4, the residual rate of retinol acetate could not be measured.

(examples 9 to 11)

The samples shown in table 3 below were prepared, and the stability of retinol acetate, the stability with time of the base (emulsion stability), and the usability (skin-friendly property, feeling of effect after application) were evaluated according to the above evaluation methods. The results are shown in Table 3.

[ Table 3]

From the results shown in Table 3, it is clear that examples 9 to 11 in which the components (a) to (c) were within the range of the present invention are excellent in the stability of retinol acetate, and also excellent in the stability with time (emulsion stability) and the usability (skin-friendly property and feeling of effect after application) of the base.

The following further shows formulation examples.

Example 12 skin cream

(Components Complex) (mass%)

(1) Retinol acetate 0.2

(2) Sorbitan tristearate 1.35

(3) Stearic acid PEG 400.81

(4) Self-emulsifying glyceryl monostearate 0.54

(5) Stearyl alcohol 0.9

(6) Behenyl alcohol 3.3

(7) Pentaerythritol Tetrakis (2-ethylhexanoate) 15

(8) Cyclopolydimethylsiloxane 2

(9) Myristyl myristate 2

(10)BHT 0.05

(11) Sodium metabisulfite 0.003

(12) Glycerol 8 for dynamite

(13) Xylitol 3

(14)1, 3-butanediol 8

(15) Xanthan gum 0.2

(16) Sodium citrate 0.06

(17) Citric acid 0.04

(18) Ethylenediaminetetraacetic acid trisodium 0.05

(19) 0.5 parts of phenoxyethanol

(20) Tranexamic acid 1

(21) 4-Methoxysalicylic acid potassium salt 1

(22) Balance of water

(production method)

The components (1) to (10) were uniformly mixed at 70 ℃ and dissolved (oil phase). On the other hand, (11) to (22) were uniformly mixed at 70 ℃ and dissolved (aqueous phase). The oil phase was added to the aqueous phase maintained at 70 ℃ and emulsified with a homomixer. After emulsification was complete, the mixture was cooled to 30 ℃.

Industrial applicability

The oil-in-water emulsion skin cosmetic composition of the present invention is stable in the incorporation of vitamins a, and is excellent in usability (skin-friendly properties, feeling of effect after application) and stability with time (emulsion stability) of a base.

Claims (3)

1. An oil-in-water type emulsified skin cosmetic composition comprising, based on the total amount of the cosmetic composition:

0.01 to 4 mass% of (a) one or more selected from vitamin A, vitamin A fatty acid esters, and salts thereof;

0.6 to 4% by mass of (b) a nonionic surfactant comprising the following components (b-1) to (b-3),

(b-1) sorbitan tristearate,

(b-2) polyethylene glycol stearate having an addition mole number of 20 to 120 of polyethylene glycol,

(b-3) glyceryl stearate with HLB of 5-8; and

1 to 10 mass% of (c) a higher alcohol having 14 to 24 carbon atoms;

and the mass ratio of the component (b-1) to the component (b) is 0.1 to 0.8.

2. The oil-in-water emulsion skin cosmetic according to claim 1, wherein the component (a) is a vitamin A fatty acid ester or a salt thereof.

3. The oil-in-water emulsion skin cosmetic according to claim 1 or 2, wherein the component (c) is stearyl alcohol and/or behenyl alcohol.