HK1146915B - Magnolia extract containing compositions - Google Patents

Description

Composition containing magnolia extract

Cross Reference to Related Applications

This application claims priority from U.S. provisional application No. 60/912,793, filed on 19/4/2007, the contents of which are incorporated herein by reference.

Technical Field

The present invention generally relates to skin care compositions. In a non-limiting aspect, the composition can be used to treat skin conditions such as telangiectasia, eye circles, and puffy eyes. In certain embodiments, the composition may include a magnolia extract and may be added to a cosmetic.

Background

Aging, prolonged exposure to adverse environmental factors, malnutrition, fatigue, and the like, can alter the visual appearance, physical attributes, or physiological functions of the skin in a manner that is considered visually unsatisfactory. Some significant changes include spider veins appearance, eye circles (e.g., black eye circles), and puffy eyes. Other changes include the formation of aged or environmentally damaged skin, which may include the formation of fine lines and wrinkles, loss of elasticity, increased sagging, loss of firmness, loss of color uniformity and tone, roughness of surface texture, and mottled pigmentation. Less obvious but measurable changes that occur as a result of skin aging or exposure to long-term environmental stimuli include a general decrease in cell and tissue viability, a decrease in cell replication rate, a decrease in skin blood flow, a decrease in water content, cumulative errors in structure and function, changes in the normal regulation of common biochemical pathways, and a decrease in the ability of the skin to reconstruct and repair itself. Many changes in the appearance and function of skin are caused by changes in the outer epidermal layer of the skin, while other changes are caused by changes in the sub-dermal layer.

1. Spider web vein

Spider veins (i.e., telangiectasia or radial varices) are formed by the dilation of a small group of blood vessels located near the surface of the skin. Spider veins are most commonly found in the face and legs, although they may occur anywhere in the body. They are visible to the naked eye and appear on the person's thighs, calves and ankles, usually as unsightly, tufted red, blue or purple veins. It is estimated that more than half of the adult female population suffers from this cosmetic problem. Factors that may contribute to the development of spider veins include genetics, pregnancy and other events that cause hormonal changes, weight gain, occupation or activity requiring long periods of sitting or standing, and the use of certain drugs.

Typical methods of treating spider veins are by cosmetic surgery (e.g., sclerotherapy, laser surgery, electro-desiccation, surgical ligation, and outpatient phlebotomy). Sclerotherapy, for example, is a surgical procedure in which veins are injected with sclerosant liquid, which causes them to collapse and disappear from view. Risks associated with sclerotherapy include the formation of blood clots in the veins, severe inflammation, adverse allergic reactions to sclerosing fluids, and skin damage that can lead to permanent scarring. Furthermore, it is common for irregular skin pigmentation (e.g., brown spots) to occur in the treatment area, and the disappearance of the pigmentation can take several months. Another problem associated with sclerotherapy is "reticular capillary linings" where reddish blood vessels appear around the treatment area, requiring further injections. Other surgical methods may have similar side effects.

2. Eye circles and puffy eyes

The skin around the periorbital region (i.e., around the eye) is thin and tender. Like all skin, the periorbital area is meshed by fine capillaries. Sometimes blood leaks from these capillaries, which can lead to the appearance of dark circles. Other known causes of dark circles include ultraviolet radiation (e.g., exposure to sunlight may increase the level of native melanin, and melanin reaches the skin surface, causing it to become black), aging (e.g., as the age increases, the skin around the eye may become thinner, causing dark circles to become more visible), fatigue (fatigue may cause the skin to be paler, causing dark circles to appear darker), allergies (e.g., allergic reactions may cause blotching in the periocular region, and conditions that cause people to rub the eyes may cause dark circles because scratching or rubbing may cause the skin to become darker), pregnancy or menstruation (e.g., during pregnancy and menstruation the skin may become pale, causing dark circles to appear darker), and undernutrition (e.g., lack of key nutrients such as iron may cause dark circles).

One method of treating dark circles includes the topical application of a composition having hydroquinone. However, hydroquinone can be toxic and it can actually cause hyperpigmentation, making dark under-eye circles darker. Cosmetic concealers may be used to cover dark circles. Unfortunately, once the concealer is removed, the dark circles are seen again. Camomile has also been used, but can cause allergic reactions.

For puffy eyes, it is a condition of swelling of the skin around the eyes, which is visually unsatisfactory. Puffy eyes can be caused by several factors including increased vascularization, capillary leakage, thinned/loose skin that can be filled with more fluid, loss of periocular fat pads that contribute to the formation of the lower pouch, allergies, dust, and contaminants that can trigger the release of chemicals that swell the periocular tissues. .

One treatment for puffy eyes involves flushing the face with cold water to reduce swelling. Other treatments include dietary restrictions (e.g., limiting salt intake), placing cucumber slices on the eyes, or placing a tea bag in cold water and then placing the bag on the eyes. These treatment regimens are limited in that their effectiveness is often negligible or transient.

3. Aged or environmentally damaged skin

Several different approaches have been used to treat damaged skin caused by aging, environmental factors, chemicals or malnutrition. One approach involves the use of specific agents to directly stimulate or inhibit selected biochemical targets. Examples include the use of retinoids to stimulate collagen and glycosaminoglycan synthesis by fibroblasts (Schiltz et al, 1986). Another approach is to use agents or processes that promote the rate of epidermal self-turnover, a process known as epidermal cell renewal. The increase in the rate of epidermal cell turnover is often caused by a faster rate of replication of epidermal basal cells and can be caused by a variety of stimuli, such as chemical or physical injury, adverse environmental conditions, or direct stimulation of basal cell division.

Some of the above methods have proven to have a number of disadvantages, such as significant irritation to the skin or skin toxicity. In addition, most of these methods involve inducing chronic damage to the skin, thereby establishing repair mechanisms. For most existing treatments, a period of time of up to weeks or months is required during which the skin is irritated, after which tolerance is established and the symptoms of irritation can be reduced and/or stopped.

Disclosure of Invention

The present invention provides compositions and methods useful for treating the appearance of human skin.

In one embodiment, a topical skin care composition is disclosed that includes, consists essentially of, or consists of at least one of the following ingredients: a magnolia extract; honokiol, magnolol, hops extract, hesperidin methyl chalcone, centella asiatica (centella asiatica extract), dipeptide valyl-tryptophan, palmityl tetrapeptide-3, corylus avellana bud extract, cucumber extract, mulberry extract, roselle flower extract, grape extract, ascorbyl glucoside, lemon extract, oat kernel extract, hydrolyzed soy protein, anise extract, illicium verum leaf extract, artemisia apiacea extract, pomelo fruit extract, or apigenin. These components may be isolated or purified before they are included in the respective compositions. It is contemplated that the compositions of the present invention may include at least 2,3, 4,5, 6, 7, 8, 9, or more of these ingredients in various combinations. The combination of these ingredients can be formulated into a mixture and then added to the composition. Non-limiting examples of Magnolia species from which Magnolia extract may be obtained include Magnolia sharehani (Magnolia acuminata), Magnolia sieboldii (Magnolia ashei), Magnolia sieboldii, Magnolia huangshanensis, Magnolia denudata, Magnolia forrestii (Magnolia frageri), Magnolia liliifolia, Magnolia japonica (magnola hypoleuca), Magnolia japonica (Magnolia kobus), Magnolia liliifolia, Magnolia loensis (Magnolia logneri), Magnolia grandiflorum, Magnolia officinalis (Magnolia officinalis), Magnolia pyramis (Magnolia pyracantha), Magnolia sieboldii, Magnolia biguai, Magnolia wudanense, Magnolia grandiflora (magna stella) are, Magnolia triphylla (Magnolia triphylla), Magnolia asteroides, Magnolia nivea (magnum biona), Magnolia biondifolia (magnum), Magnolia biondifolia (mangnolia yunnata), Magnolia biondii (mangnolia yunnaria, michelia figo-a, Magnolia sieboldii, and michelia figo-containing Magnolia. In certain embodiments, the composition may comprise magnolia extract and isolated or purified honokiol or magnolol, or a combination of all three. In a particular embodiment the magnolia extract is magnolia biondii extract. In other aspects, the composition can include magnolia extract and hops extract, magnolia extract and hesperidin methyl chalcone and centella asiatica, magnolia extract and dipeptide valyl-tryptophan, magnolia extract and palmitoyl tetrapeptide-3, magnolia extract and corylus avellana bud extract, magnolia extract and a plant mixture including cucumber extract, mulberry extract, hibiscus sabdariffa flower extract and grape extract, magnolia extract and ascorbyl glucoside, lemon extract and cucumber extract, magnolia extract and a mixture of oat kernel extract, hydrolyzed soy protein, aniseed extract, illicium verum leaf extract and hibiscus sabdariffa flower extract, magnolia extract and artemisia annua extract, magnolia extract and pomelo fruit extract or magnolia extract and isolated or purified apigenin. In certain aspects, the grapefruit fruit extract includes at least 90 wt% apigenin. The composition may also include cooling agents (e.g., agents that provide a cooling sensation when applied to the skin). The cooling agent can be one known in the art, such as, for example, menthol or menthol derivatives (e.g., menthyl lactate and menthone glycerol acetal).

In certain aspects, the composition may be formulated to have a pH of about less than 4.0, or any integer derived from 4.0, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 5.0, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6.0, 6.1, 6.2, 6.3, 6.4, 6.5, 6.6, 6.7, 6.8, 6.9, 7.0, 7.1, 7.2, 7.3, 7.4, 7.5, 7.6, 7.7, 7.8, 7.9, 8.0, 8.1, 8.2, 8.3, 8.4, 8.5, 8.6, 8.7, 8.8.8, 9, 9.9, 9.0, 8.1, 8.3, 8.4, 8.5, 9.6, 9.7, 9.8, 9.9, 9.9.9, 10.9, 10.0, 11.9, 11, 11.9.6, 10.9.9, 10, 10.6, or more. In other aspects, the composition can be formulated as a cosmetic product (e.g., skin cleanser, moisturizer, concealer, etc.). The compositions can be included in a cosmetic carrier (e.g., an emulsion, cream, lotion, solution, anhydrous base, gel, ointment, or the like). The composition may be in the form of a dry, powder, liquid, solid, semi-solid or, spray or aerosol. It is contemplated that the compositions of the present invention may be used in combination with other cosmetic products (e.g., the compositions of the present invention may be formulated into concealer products that may be used in combination with foundation products). The composition may be formulated for application to the skin at least 1, 2,3, 4,5, 6, 7 or more times per day.

As described throughout this specification, the ingredients in the compositions of the present invention may be present in the compositions in various amounts. The amount can be measured by the total weight or volume of the composition. By way of example only, ingredients may be included in the composition at 0.0001, 0.001, 0.01, 0.1, 1, 2,3, 4,5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 96, 97, 98, 99% or more by weight or volume of the total composition, or any range or integer percentage derivable therein. In certain aspects, the magnolia extract may be about 0.1 wt% to about 10.0 wt% in the composition. The ratio of any ingredient to another ingredient in the composition may be about 1: 1, 2: 1, 3: 1, 4: 1, 5: 1, 6: 1, 7: 1, 8: 1, 9: 1, 10: 1, 11: 1, 12: 1, 13: 1, 14: 1, 15: 1, 16: 1, 17: 1, 18: 1, 19: 1, 20: 1, 21: 1, 22: 1, 23: 1, 24: 1, 25: 1, 26: 1, 27: 1, 28: 1, 29: 1, 30: 1, 31: 1, 32: 1, 33: 1, 34: 1, 35: 1, 36: 1, 37: 1, 38: 1, 39: 1, 40: 1, 50: 1, 60: 1, 70: 1, 80: 1, 90: 1, 100: 1 or more, or any number derivable therein, by weight or volume of the total composition. In another aspect, the ratio of any ingredient to another ingredient in the composition can be about 1: 2, 1: 3, 1: 4, 1: 5, 1: 6, 1: 7, 1: 8, 1: 9, 1: 10, 1: 11, 1: 12, 1: 13, 1: 14, 1: 15, 1: 16, 1: 17, 1: 18, 1: 19, 1: 20, 1: 21, 1: 22, 1: 23, 1: 24, 1: 25, 1: 26, 1: 27, 1: 28, 1: 29, 1: 30, 1: 31, 1: 32, 1: 33, 1: 34, 1: 35, 1: 36, 1: 37, 1: 38, 1: 39, 1: 40, 1: 50, 1: 60, 1: 70, 1: 80, 1: 90, 1: 100, or more, or any number derived therefrom, by weight or volume of the total composition.

It is also contemplated that the viscosity of the composition can be selected to achieve a desired result (e.g., the viscosity of such composition can be from about 1cps to greater than or derived from 1000,000cps, or any range or integer of cps, depending on the type of composition desired (e.g., 2cps, 3, 4,5, 6, 7, 8, 9, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 2000, 3000, 4000, 5000, 6000, 7000, 8000, 9000, 10000, 20000, 30000, 40000, 50000, 60000, 70000, 80000, 90000, 100000, 200000, 300000, 400000, 500000, 600000, 700000, 800000, 900000, 1000000cps, etc.).

The compositions of the present invention may include additional ingredients that may be included in the cosmetic or pharmaceutical compositions. As explained throughout this specification, non-limiting examples of additional ingredients may include essential oils, volatile and non-volatile oils, thickeners, surfactants, preservatives, silicone-containing compounds, absorbents, adsorbents, chelating agents, lubricants, solvents, moisturizers (including, for example, emollients, humectants, film formers, occlusive agents, agents that affect the natural moisturizing mechanism of the skin), water repellents, antioxidants, uv absorbers, anti-irritants, antimicrobial agents, dyes and colorant ingredients, or structuring agents, or any combination thereof.

In other aspects of the invention, methods of treating a skin condition are disclosed, the methods comprising topically applying to the skin an effective amount of a composition of the invention. Topical application of the composition can treat or prevent the skin condition. The efficacy of the composition can be compared to skin treated without the composition of the present invention. In certain non-limiting embodiments, skin treatment may be localized to and/or around the area where the composition is applied to the skin. The skin may be facial, torso, back, neck, ears, pelvis, arms, hands, legs (e.g., ankles, knees, thighs), feet, or hip skin. For example, topical application of a composition wherein topical application of the composition treats a skin condition. Non-limiting examples of skin conditions that may be treated or prevented with the compositions of the present invention include telangiectasia (i.e., spider veins), eye circles (e.g., dark eye circles), puffy eyes, pruritus, freckles, age spots, senile purpura, keratosis, melasma, pimples, wrinkles, fine lines, nodules, sun damaged skin, dermatitis (including but not limited to seborrheic dermatitis, nummular dermatitis, contact dermatitis, atopic dermatitis, exfoliative dermatitis, perioral dermatitis, and stasis dermatitis), psoriasis, folliculitis, rosacea, acne, impetigo, erysipelas, erythrasma, eczema, or pigmentation. In certain aspects, the skin condition may result from exposure to ultraviolet light, aging, radiation, chronic sun exposure, environmental pollutants, air pollution, wind, cold, heat, chemicals, disease pathologies, or smoking. The skin to be treated may be aged, nutritionally damaged or environmentally damaged skin. In certain aspects, the composition can be topically applied in an amount effective to increase the turnover rate of the stratum corneum of the skin, collagen synthesis production of the skin, lipogenesis of the skin, firmness of the skin, or elasticity of the skin. In other aspects, the composition can be topically applied in an amount effective to reduce or inhibit the formation of new capillary blood vessels in or near the skin, blood flow to the skin, fluid volume in or near the skin, or melanin production in the skin.

Also disclosed are kits that can include the compositions of the invention. In certain non-limiting aspects, the composition is included in a container. The container may be a bottle, a dispenser, or a package, etc. The container may be configured to dispense a predetermined amount of the composition. The container may be configured to dispense the composition in the form of a semi-solid, liquid, spray or aerosol. In certain aspects, the kit can include indicia on its surface and/or instructions for using the composition.

In other aspects of the invention, the compositions may be used as part of a regimen for treating a skin condition. For example, the protocol may include the first application of the composition of the present invention as disclosed throughout this specification. The scheme may then include additional applications that are the same as, similar to, or different from the first application. Additional applications may include, for example, a second, third, fourth, fifth, sixth, seventh, eighth, ninth, tenth, or more applications of the compositions of the present invention and/or the use of another method of treating a particular skin condition (e.g., other compositions, surgery, etc.).

It is contemplated that any embodiment discussed in this specification can be implemented using any method or composition of the invention, and vice versa. In addition, the compositions of the present invention can be used to practice the methods of the present invention.

The terms "inhibit," "reduce," or "prevent," or any variation of these terms, as used in the claims and/or the specification, include any measurable decrease or complete inhibition to achieve a desired result.

The term "effective" when used in the specification and/or claims means sufficient to achieve a desired, expected, or expected result.

The use of the words "a" or "an" when used in conjunction with the term "comprising" in the claims and/or the specification may mean "one", but it is also consistent with the meaning of "one or more", "at least one", and "one or more".

The term "about" or "approximately" is defined as being close to, and in one non-limiting embodiment, within 10%, within 5%, within 1%, and in some aspects, within 0.5%, as understood by one of ordinary skill in the art.

The use of the term "or" in the claims is intended to mean "and/or" unless explicitly indicated to be only an alternative or that alternatives are mutually exclusive, although the disclosure supports the definition of only alternatives and "and/or".

As used in this specification and claims, the words "comprise" (and any form of comprise), (including), (having), (including.

Other aspects, features and advantages of the present invention will be apparent from the following detailed description. It should be understood, however, that the detailed description and the examples, while indicating specific embodiments of the invention, are given by way of illustration only. In addition, it is contemplated that variations and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description.

Detailed Description

In today's image-focused society, people are constantly seeking products that improve the appearance of skin. The appearance of skin can be negatively affected by the condition of the skin. For example, spider web veins (i.e., telangiectasia or radial varicose veins) may appear as unsightly, clustered red, blue, or purple veins on a person's skin (e.g., face, thighs, calves, ankles, arms, torso, hips, etc.). Eye circles and puffy eyes may show as dark circles and swelling around the orbital area, respectively. In addition, aged or environmentally damaged skin may include fine lines and wrinkles in appearance, loss of elasticity, increased sagging, loss of firmness, loss of color uniformity or tone, rough surface texture, and mottled pigmentation.

In one aspect, the present invention provides compositions and methods for treating skin conditions. In one non-limiting embodiment, the compositions of the present invention can be used to treat spider veins, eye circles, puffy eyes, or environmentally damaged skin by topically applying the compositions of the present invention to an area of skin in need of such treatment. As referred to throughout this specification, the composition may include at least one or any combination of the following ingredients: a magnolia extract; honokiol, magnolol, hops extract, hesperidin methyl chalcone, centella asiatica, dipeptide valyl-tryptophan, palmitoyl tetrapeptide-3, corylus avellana bud extract, cucumber extract, mulberry extract, hibiscus sabdariffa flower extract, grape extract, ascorbyl glucoside, lemon extract, oat kernel extract, hydrolyzed soybean protein, anise extract, illicium simsii leaf extract, artemisia annua extract, pomelo fruit extract, or apigenin. These and other non-limiting aspects of the invention are described in more detail in the following sections.

A. Composition (I)

The following paragraphs provide non-limiting examples of ingredients that may be included in the compositions of the present invention. The composition may include any one of the following ingredients or a combination of these ingredients. It is contemplated that other ingredients may also be added to the composition. In addition, one of ordinary skill will recognize that the components may be commercially available, may be chemically synthesized, or may be isolated or purified by known methods from sources that include the components.

1. Magnolia extract

In certain non-limiting embodiments, the compositions of the present invention may include magnolia extract. The magnolia extract may be obtained or derived from a variety of sources (e.g., flowers, bark, seed cones, etc.) of the magnolia plant. Generally, magnolia is a large genus of magnolia subfamily of the magnoliaceae family having about 210 species of flowering plants. The magnolia extract may be obtained from a species of the magnolia family. Non-limiting examples of such species include Magnolia sharpleaf, Magnolia sieboldii, Magnolia xanthiifolia, Magnolia tibetana, Magnolia yulan, Magnolia delavayi, Magnolia johnsonii, Magnolia japonica, Magnolia biondii, Magnolia liliifolia, Magnolia lodendri, Magnolia grandiflorum, Magnolia officinalis, Magnolia pyramis (magnlia pyramidata), Magnolia sieboldii, Magnolia biondii, Magnolia wushurica, Magnolia biondii, Magnolia bayana, Magnolia virginiana, Magnolia baphicacantha, and michelia. A more comprehensive listing of species of the Magnoliaceae family can be found in Figlar & Nooteboom (2004), which is incorporated herein by reference.

The magnolia extract may reduce blood flow near the surface of the skin in a variety of ways (e.g., vasoconstriction, inhibition of angiogenesis, vascular endothelial cell migration, or tubule formation in or near an area of the skin that has been contacted with the magnolia extract-containing composition). Active ingredients that have been identified in magnolia flower, bark, and seed cone extracts include magnolol, dihydroxydihydromagnolol, honokiol, and dihydrohonokiol. These active ingredients are polyphenol-containing compounds, wherein honokiol is an isomer of magnolol.

Commercially available magnolia extracts are obtained from a variety of different sources. For example, magnolia Extracts are available from Carrubba, Inc. (Milford connection), Arcadia Herbs & Alternatives (Langhorn, Pennsylvania), and Herbal Extracts Plus (Croydon, Pennsylvania). Alternatively, one of ordinary skill in the art would be able to isolate magnolia extract from magnolia flowers, bark, or seed cones using any suitable isolation and purification method known in the art (see, e.g., Bai et al (2003)).

2. Honokiol and magnolol

The compositions of the present invention may comprise honokiol or magnolol or both. As mentioned above, they are bisphenol-containing compounds, wherein honokiol is an isomer of magnolol. These compounds are useful for reducing blood flow near the surface of the skin by a variety of mechanisms (e.g., vasoconstriction, inhibition of angiogenesis, migration of vascular endothelial cells, or tubule formation in or near an area of the skin that has been contacted with a composition comprising honokiol or magnolol). The chemical structures of these compounds are schematically shown below:

honokiol and magnolol can be isolated or purified from magnolia extracts (e.g., flower, bark, and seed cone extracts), or other extracts that include these compounds, by standard techniques. Alternatively, these compounds are commercially available (e.g., Wako Chemical Company (Tokyo, Japan)) or can be synthesized using conventional Chemical synthesis techniques known to those of ordinary skill in the art (see, e.g., Vollhardt and Schore, 1994).

3. Chemical compounds and extracts

The composition of the invention may comprise hop extract, centella asiatica (centella asiatica extract), hesperidin methyl chalcone, dipeptide valyl-tryptophan, palmitoyl tetrapeptide-3, corylus avellana bud extract, cucumber extract, mulberry extract, hibiscus sabdariffa flower extract, grape extract, ascorbyl glucoside, lemon extract, oat kernel extract, hydrolyzed soy protein, anise extract, illicium verum leaf extract, artemisia annua extract, pomelo fruit extract or apigenin or any combination or mixture of these components.

For example, the hops extract or hops extract can be used to reduce blood flow near the surface of the skin by vasoconstriction, inhibition of angiogenesis, migration of vascular endothelial cells, or tubule formation in or near the area of the skin that has been contacted with the composition containing hops extract. Hops extracts are available from a variety of commercial sources (e.g., Actives International (Allendale, New Jersey)) and can also be isolated or purified from hops by standard isolation and purification techniques. Non-limiting examples of the various hops from which the hops extract can be obtained include hops lupulus (humulus lupulus var. lupulus), heart-leaf hops (humulus lupulus var. cordifolia), humulus lupulus var. lupulus (syn. h. americanus) (hops distributed in the eastern part of the north america), humulus lupulus var. neometricus (hops distributed in the western part of the north america), and humulus lupulus var. puscuens (hops distributed in the central part of the north america). The hop extract comprises active ingredients such as humulene and lupinene (lupulene).

Centella asiatica (centella asiatica) extracts are rattan-like plants native to india and southeast asia. Such ingredients may be used to enhance the capillary microvascular barrier and may improve the overall function (e.g., effective or improved blood circulation) of blood vessels in or near areas of the skin that have been exposed to compositions containing centella asiatica extract. Centella asiatica extracts are available from a variety of commercial sources (e.g., Naturex (south heckensk, New Jersey)), and can also be isolated or purified from centella asiatica-containing plants by standard isolation and purification techniques. Centella asiatica extract contains compounds such as asiaticoside (triterpenoid), brahmoside (brahmoside) and brahminoside (both saponins), madecassoside (a glycoside with anti-inflammatory properties), madecassoside, vitamin B1, riboflavin, vitamin B6, vitamin K, aspartic acid, glutamic acid, serine, threonine, alanine, lysine, histidine, magnesium, calcium and sodium.

Hesperidin methyl chalcone, the dipeptide valyl-tryptophan (i.e., dipeptide-2 including valine and tryptophan) and palmityl tetrapeptide-3 (which is the reaction product of palmitic acid and a synthetic peptide containing glycine, glutamine, proline and arginine) can also be included in the compositions of the present invention. Hesperidin, a bioflavonoid found in Citrus peels such as sweet orange peel (Citrus aurantium var. sinensis), can be converted to hesperidin methyl chalcone by extracting hesperidin from its source and subjecting the extract to an alkaline solution. This converts hesperidin into hesperidin chalcone, which can then be methylated by any known methylation process to produce hesperidin methyl chalcone. Hesperidin methyl chalcone can enhance the capillary microvascular barrier in or near an area of skin that has been contacted with a composition comprising this ingredient. By Sederma SAS (Cedex, France) under the trademark DIPEPTIDE VW^TMThe dipeptide valyl-tryptophan is sold for use when applied to the skin to mobilize and drain fluids from the skin tissue (to reduce puffy eyes). Available through Sederma SAS (Cedex, France) under the trademark N-PALMITOYL RIGIN^TMThe palm tetrapeptide-3 of (a), can reduce local inflammation in skin tissue and restore skin firmness and elasticity when applied to the skin. In addition, of these three componentsThe mixture was also passed through Dermaxime (Gauteng, South Africa) under the trade name EYELISS^TMAnd (5) selling.

The corylus (hazel) extract can moisturize the skin and when applied to the skin can be used to mobilize and drain fluids from the skin tissue (can reduce edema of the eye). The extract can be obtained from bud, flower, leaf, nut, bark, etc. of hazel plant. Hazel extracts are available from a variety of commercial sources (e.g., Mountain Rose Herbs, Eugene Oregon), and can also be isolated or purified from hazel plants by standard isolation and purification techniques. Non-limiting examples of species from which hazel extracts can be obtained include Corylus heterophylla, Corylus avellana, Corylus heterophylla (Corylus ferox), Corylus heterophylla (Corylus maxima), Corylus heterophylla (Corylus sieboldiana) and Corylus tibetana (Corylus tibetaca).

When applied to the skin, Cucumber (Cucumber) extract, mulberry extract, hibiscus flower extract, grape extract can be used to lighten or even the skin color by inhibiting tyrosinase activity. These components are available from a variety of commercial sources, and can also be isolated or purified from plants containing these extracts by standard isolation and purification techniques. In certain non-limiting aspects, mixtures of these ingredients can be used to achieve a brighter or more uniform skin tone. This mixture was passed through a GreenTech SA (Saint Beauzire, France) under the trademark CLEILIYS^TMAnd (5) selling.

When applied to the skin, ascorbyl glucoside may also be used to lighten or even the skin color by inhibiting tyrosinase activity. Ascorbyl glucoside is a derivative of ascorbic acid (vitamin C) which includes linked glucose monosaccharides. In an ascorbyl glucoside molecule, glucose is usually bound to the OH group of ascorbic acid. The following is a non-limiting example of one form of ascorbyl glucoside, ascorbic acid-2 glucoside:

ascorbic acid-2-glucoside

Other non-limiting examples of ascorbyl glucosides include ascorbic acid 1-glucoside (including 1-O-alpha-D-glucopyranosyl-L-ascorbic acid and 1-O-beta-D-glucopyranosyl-L-ascorbic acid), ascorbic acid 2-glucoside (including 2-O-alpha-D-glucopyranosyl-L-ascorbic acid and 2-O-beta-D-glucopyranosyl-L-ascorbic acid), ascorbic acid 3-glucoside (including 3-O-alpha-D-glucopyranosyl-L-ascorbic acid or 3-O-beta-D-glucopyranosyl-L-ascorbic acid), Ascorbic acid 5-glucosides (including 5-O- α -D-glucopyranosyl-L-ascorbic acid or 5-O- β -D-glucopyranosyl-L-ascorbic acid), and ascorbic acid 6-glucosides (including 6-O- α -D-glucopyranosyl-L-ascorbic acid or 6-O- β -D-glucopyranosyl-L-ascorbic acid). Ascorbyl glucoside is commercially available (e.g., Hayashibara Biochemical Laboratories, Inc.). Formulations of ascorbyl glucoside are also known in the art (see, e.g., U.S. Pat. Nos. 5,084,563; 5,252,722; 5,272,136; 5,388,420; 5,432,161; 5,843,907; and 5,508,391).

The composition of the present invention may include an extract preparation including Cucumber (cuumber) extract and lemon. When applied to the skin, the preparation can be used to lighten or even the skin color by inhibiting tyrosinase activity. This formulation is sold under the trademark UNINONTAN U34 by Chesham Chemicals, Ltd (United Kingdom)^TMAnd (5) selling. UNINONTAN U34^TMThe ingredients of the formulation included cucumber extract (cucumber) (15.0%), lemon extract (lemon) (16.0%), sodium citrate (20.0%), propylene glycol (23.5%) and water (25.5%).

Non-limiting examples of anti-irritants and antioxidants that may be included in the compositions of the present invention include oat (Oat) extract, hydrolyzed soy protein, anise extract, illicium verum leaf extract, and roselle (roselle) flower extract, or any combination or mixture of these ingredients.These components are obtained from a variety of commercial sources and can also be isolated or purified from plants containing these extracts by standard isolation and purification techniques. For example, a composition comprising an extract of oats is passed through Symrise (Holzminden, Germany) under the trademark DRAGO CALM^TMAnd (5) selling. Hydrolyzed soy protein was obtained by MGP Ingredients, Inc. (Atchison, Kansas) under the trademark AQUA PRO SP^TMAnd (5) selling. A mixture of Anetholea anisa (anise) extract, illicium verum (fresh fruit of Piper nigrum L.) leaf extract, Hibiscus sabdariffa (Hibiscus sabdariffa L.) flower extract is obtained by Southern Cross Botanicals (Knockrow, Australia) under the trademark MOUNTAIN HARVEST^TMAnd (5) selling.

Artemisia capillaris Thunb (Artemisia annua L.) extract can stimulate lipogenesis and help protect periocular fat pad. This is beneficial against fine lines and wrinkles and thinned/flaccid skin. The Artemisia annua extract is obtained by Silab (Cedex, France) under the trademark PULPACTYL^TMCommercially, these extracts can also be isolated or purified from plants containing them by standard isolation and purification techniques.

When applied to the skin, the extract of the peel of grapefruit (grapefruit) has anti-hyaluronidase, anti-angiogenic, and anti-inflammatory properties. The composition can be used as soothing agent for acute or chronic inflammation, and can help repair skin damaged by excessive ultraviolet radiation. The active ingredient in grapefruit extract is apigenin. Grapefruit extract is obtained by Actives International (Allendale, New Jersey) under the trademark VIAPURE CITRUS^TMCommercially, these extracts can also be isolated or purified from plants containing them by standard isolation and purification techniques.

4. Cosmetic composition

The compositions of the present invention may contain other ingredients. Non-limiting examples of additional ingredients that may be added to Cosmetic formulations can be found in International Cosmetic Ingredient Dictionary, 10 th edition, 2004, which is incorporated herein by reference. Such ingredients include surfactants, preservatives, absorbents, adsorbents, chelating agents, lubricants, solvents, moisturizers (including, for example, emollients, humectants, film formers, sealants, and agents that affect the natural moisturizing mechanism of the skin), water repellents, antioxidants, ultraviolet absorbers, anti-irritants, vitamins, trace metals, antimicrobials, dyes, and colorant components, and/or structurants (see, for example, McCutcheon's Functional materials north American Edition 2001 and McCutcheon's Emulsifiers & degerntsnorth American Edition 2001; U.S. patent No. 6,290,938).

a. Surface active agent

The compositions of the present invention may also include one or more surfactants. Surfactants can reduce interfacial tension between phases and improve formulations and formulation stability. Surfactants can be nonionic, cationic, anionic, crypto-anionic (cryptoionic) and amphoteric Emulsifiers (see McCutcheon's Emulsifiers & Detergents (2001); U.S. Pat. No. 5,011,681; 4,421,769; 3,755,560; 6,117,915). Non-limiting examples include glycerol esters, propylene glycol esters, polyethylene glycol fatty acid esters, polypropylene glycol fatty acid esters, sorbitol esters, sorbitan esters, carboxylic acid copolymers, sugar esters and ethers, ethoxy ethers, ethoxylated alcohols, alkyl phosphate esters, polyoxyethylene fatty ether phosphate esters, fatty acid amides, acyl lactylates, soaps, TEA stearate, DEA oleyl polyether-3 phosphate, polyethylene glycol 20 sorbitan monolaurate (Tween 20), polyethylene glycol 5 soya sterol, steareth-2, steareth-20, steareth-21, ceteth-20, PPG-2 methyl glucose ether stearate, ceteth-10, cetyl phosphate, potassium cetyl phosphate, diethanolamine cetyl phosphate, Tween 20, Tween 60, Tween 80, Glyceryl stearate, PEG-100 stearate, tyloxapol, and mixtures thereof.

b. Preservative

Non-limiting examples of preservatives that can be used in the present invention include quaternary ammonium preservatives such as polyquaternium-1 and benzalkonium halides (e.g., benzalkonium chloride ("BAC") and benzalkonium bromide), parabens (e.g., methyl and propyl parabens), phenoxyethanol, benzyl alcohol, chlorobutanol, phenol, sorbic acid, thimerosal, or combinations thereof.

c. Moisture-retaining agent

Non-limiting examples of humectants include amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerol polymers, ethylene glycol, 1, 2, 6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysates, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG-15 butanediol, polyglycerol sorbitol, salts of pyrrolidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol.

Other examples include acetylated lanolin, acetylated lanolin alcohol, acrylate/C10-30 alkyl acrylate cross-linked copolymer, acrylate copolymer, alanine, algae extract, aloe vera extract, aloe vera gel, hollyhock extract, aluminum starch octenyl succinate, aluminum stearate, almond oil, arginine aspartic acid, arnica extract, ascorbic acid, ascorbyl palmitate, aspartic acid, avocado (avocado) oil, barium sulfate, sphingolipids, butanol, beeswax, behenyl alcohol, beta-sitosterol, BHT, birch (birch) bark extract, borage extract, 2-bromo-2-nitropropane-1, 3-diol, cremains (ruscus aculeatus) extract, butylene glycol, calendula extract, Calendula oil, candelilla wax, canola oil, caprylic/capric triglyceride, cardamom oil, palm (carnauba) wax, carrageenan (carrageen), carrot oil, castor oil, ceramide, ozokerite, ceteareth-5, ceteareth-12, ceteareth-20, cetearyl octanoate, ceteth-20, ceteth-24, cetoacetate, cetearyl octanoate, cetearyl palmitate, chamomile (chamomile) oil, cholesterol ester, cholesteryl hydroxystearate, citric acid, sage clary oil, cocoa butter, cocoa-octanoate/decanoate, coconut oil, collagen amino acids, corn oil, fatty acids, decyl oleate, dextrin, diazoalkyl imidazolium urea, and mixtures thereof, Dimethicone copolyol, dimethiconol, dioctyl adipate, dioctyl succinate, dipentaerythritol hexacaprylate/hexacaprate, DMDM hydantoin, DNA, erythritol, ethoxydiglycol, ethyl linoleate, eucalyptus globulus oil, evening primrose oil, fatty acids, fructose (fructose), gelatin, geranium oil, glucosamine, glucose glutamate, glutamic acid, glyceryl polyether-26, glycerol distearate, glyceryl hydroxystearate, glyceryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl oleate, glyceryl stearate SE, glycine, glycol stearate SE, glycosaminoglycan, grape seed oil, hazelnut (hazel nut) fruit oil, hexenyl glycol, ethylene glycol, glycerol stearate, glycine, glycol stearate SE, glycosaminoglycan, and mixtures thereof, Honey, hyaluronic acid, safflower oil, hydrogenated castor oil, hydrogenated cocoa butter, hydrogenated coconut oil, hydrogenated lanolin, hydrogenated lecithin, hydrogenated glyceryl palmitate, hydrogenated palm kernel oil, hydrogenated soybean oil, hydrogenated glyceryl tallowate, hydrogenated vegetable oil, hydrolyzed collagen, hydrolyzed elastin, hydrolyzed glycosaminoglycan, hydrolyzed keratin, hydrolyzed soy protein, hydroxylated lanolin, hydroxyproline, imidazolidinyl urea, iodopropynyl butylcarbamate, isocetyl palmitate, isocetyl stearoyloxy stearate, isodecyl oleate, isopropyl isostearate, isopropyl lanolate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isostearamide DEA, isostearic acid, isostearyl lactate, isostearyl pivalate, jasmine (mongolian flower) oil, jojoba (jojoba) oil, Seaweed ash, kukukui fruit oil, lactamide MEA, lanolin alcohol polyether-16, lanolin alcohol polyether-10 acetate, lanolin acids, lanolin alcohols, lanolin oil, lanolin wax, lavender oil, lecithin, lemon oil, linoleic acid, linolenic acid, macadamia nut oil, magnesium stearate, magnesium sulfate, maltitol, chamomile (chamomile) oil, methylgluco-sesquistearate PCA, microcrystalline wax, mineral oil, mink oil, Mortierella oil, myristyl lactate, myristyl myristate, myristyl propionate, neopentyl glycol dicaprylate/dicaprate, octyldodecanol myristate, octyldodecanol stearyloxystearate, octyl hydroxystearate, octyl palmitate, octyl salicylate, octyl stearate, oleic acid, olive (olive) petroleum, orange (sweet orange) oil, palm (oil palm) oil, palmitic acid, pantethine, panthenol, panthenyl ethyl ether, paraffin, PCA, persic oil, peanut (groundnut) oil, PEG-8C12-18 ester, PEG 15 cocoamine, PEG 150 distearate, PEG-60 glyceryl isostearate, PEG-5 glyceryl stearate, PEG-30 glyceryl stearate, PEG-7 hydrogenated castor oil, PEG40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG20 methyl glucose sesquistearate, PEG40 sorbitan monooleate, PEG-5 soya sterol, PEG 10 soya sterol, PEG stearate, PEG 8 stearate, PEG-20 stearate, PEG-32 stearate, PEG40 stearate, PEG-50 stearate, PEG 100 stearate, PEG 150 stearate, pentadecanolide, Peppermint oil, petrolatum, phospholipids, polyamino acid polysaccharide condensates, polyglycerol-3 diisostearate, polyquaternium-24, tween 20, tween 40, tween 60, tween 80, tween 85, potassium myristate, potassium palmitate, potassium sorbate, potassium stearate, propylene glycol dicaprylate/caprate, propylene glycol dicaprylate, propylene glycol dipelargonate, propylene glycol laurate, propylene glycol stearate SE, PVP, pyridoxine dipalmitate, quaternium-15, quaternium-18 hectorite, quaternium-22, retinol palmitate, rice (rice) bran oil, RNA, rosemary oil, rose oil, sage oil, salicylic acid, sandalwood oil, serine, serum protein, sesame oil, shea butter (shea butter), silk powder, sodium sulfate, chondroitin sulfate, Sodium hyaluronate, sodium lactate, sodium palmitate, sodium PCA, sodium polyglutamate, sodium stearate, water-soluble collagen, sorbic acid, sorbitan laurate, sorbitan oleate, sorbitan palmitate, sorbitan sesquioleate, sorbitan stearate, sorbitol, soybean (wild soybean) oil, sodium hyaluronate, sodium lactate, sodium palmitate, sodium PCA, sodium stearate, water-soluble collagen, sorbitol, sorbitan laurate, sorbitan oleate, sorbitan stearate, sorbitan palmitate, sorbitan sesquioleate, sorbitan stearate, sodium stearate,

sphingolipids, squalane, squalene, stearamide MEA stearate, stearic acid, stearyloxydimethicone, stearyloxytrimethylsilane, stearyl alcohol, stearyl glycyrrhetinate, stearyl heptanoate, stearyl stearate, sunflower seed oil, sweet almond (sweet almond) oil, synthetic beeswax, vitamin E, tocopheryl acetate, tocopheryl linoleate, behenyl sanbehenate, tridecyl pivalate, tridecyl stearate, triethanolamine, tristearin, urea, vegetable oil, water, wax, wheat germ oil, and ylang oil.

d. Skin-moistening agent

Examples of emollients include, but are not limited to, vegetable oils, mineral oils, silicone oils, synthetic and natural waxes, medium chain triglycerides, petrolatum, lanolin, magnesium aluminum hydroxide stearate (which may also act as a water repellant), and fatty acid esters. Non-limiting examples of vegetable oils include safflower oil, corn oil, sunflower seed oil, and olive oil.

e. Antioxidant agent

Examples of antioxidants include, but are not limited to, acetylcysteine, ascorbic acid polypeptide, ascorbyl dipalmitate, ascorbyl methylsilanol pectate, ascorbyl palmitate, ascorbyl stearate, BHA, BHT, t-butylhydroquinone, cysteine hydrochloride, diamylhydroquinone, di-t-butylhydroquinone, dicetyl thiodipropionate, dioleyl tocopheryl methylsilanol, disodium ascorbyl sulfate, distearyl thiodipropionate, ditridecyl thiodipropionate, lauryl gallate, erythorbic acid, ascorbic acid esters, ethyl ferulate, ferulic acid, gallic acid, hydroquinone, isooctyl thioglycolate, kojic acid, magnesium ascorbate, magnesium ascorbyl phosphate, methylsilanol ascorbic acid, natural plant antioxidants such as green tea or grape seed extract, green tea or grape seed extract, Nordihydroguaiaretic acid, octyl gallate, thiopheneacetic acid, ascorbyl phosphate, potassium ascorbate, propyl gallate, quinone, rosmarinic acid, sodium ascorbate, sodium bisulfite, sodium erythorbate, sodium metabisulfite, sodium sulfite, superoxide dismutase, sodium thioglycolate, sorbitolfural, thiodiethanol, thiodiglycide, thioglycolic acid, thiolactic acid, thiosalicylic acid, tocopheryl polyether-5, tocopheryl polyether-10, tocopheryl polyether-12, tocopheryl polyether-18, tocopheryl polyether-50, vitamin E, tocoferol, tocopheryl acetate, tocopheryl linoleate, tocopheryl nicotinate, tocopheryl succinate, and tris (nonylphenol) phosphite.

f. Compounds having ultraviolet absorbing properties

Non-limiting examples of compounds having ultraviolet light absorbing properties that may be used with the compounds of the present invention include benzophenone, benzophenone-1, benzophenone-2, benzophenone-3, benzophenone-4, benzophenone-5, benzophenone-6, benzophenone-7, benzophenone-8, benzophenone-9, benzophenone-10, benzophenone-11, benzophenone-12, benzyl salicylate, butyl p-aminobenzoate, cinnamate, cinoxate, DEA-methoxycinnamate, methyl diisopropylcinnamate, dihydroxypropyl PABA ethyl ester, diisopropyl cinnamate, methoxycinnamate ethyl ester, PABA ethyl ester, urocanic acid ethyl ester, glyceryl caprylate dimethoxycinnamate, PABA glyceride, ethylene glycol salicylate, and mixtures thereof, Homosalate, isoamyl p-methoxycinnamate, PABA esters, Parsol 1789, isopropyl benzyl salicylate, and octyl methoxycinnamate.

g. Structuring agent

In other non-limiting aspects, the compositions of the present invention can include a structurant. In certain aspects, assist in providing rheology to the composition to promote stability of the composition. In other aspects, the structurant may also act as an emulsifier or surfactant. Non-limiting examples of structurants include stearic acid, palmitic acid, stearyl alcohol, cetyl alcohol, behenyl alcohol, stearic acid, palmitic acid, the polyethylene glycol ether of stearyl alcohol having an average of about 1 to about 21 ethylene oxide units, the polyethylene glycol ether of cetyl alcohol having an average of about 1 to about 5 ethylene oxide units, and mixtures thereof. Other non-limiting examples can be found in International Cosmetic Ingredient Dictionary, 10 th edition, 2004, which is incorporated by reference.

h. Silicon-containing ketone compound

In a non-limiting aspect, silicone-containing compounds include any member of the family of polymers whose molecular backbone consists of alternating silicon and oxygen atoms, and which have pendant groups attached to the silicon atoms. By varying the-Si-O-chain length, pendant groups, and by crosslinking, silicones can be synthesized as a variety of materials. Their consistency can range from liquid to gel to solid.

The silicone-containing compounds useful in the present invention include those described in the specification or known to those of ordinary skill in the art. Non-limiting examples include silicone oils (e.g., volatile and non-volatile oils), gels, and solids. In certain aspects, the silicone-containing compound includes a silicone oil such as an organopolysiloxane. Non-limiting examples of organopolysiloxanes include dimethicone, cyclomethicone, polysiloxane-11, phenyl trimethicone, trimethylsilyldimethicone, stearyloxytrimethylsilane, or mixtures of these and other organosiloxane materials in any given ratio to achieve the desired consistency and application characteristics (e.g., application to a particular area such as skin, hair, or eye) depending on the intended application. "volatile silicone oils" include silicone oils having a low heat of vaporization, i.e., generally less than about 50 calories per gram of silicone oil. Non-limiting examples of volatile silicone oils include: cyclomethicones such as Dow Corning 344Fluid, Dow Corning 345Fluid, Dow Corning244Fluid and Dow Corning 245Fluid, vollate Silicon 7207(Union carbide Corp., Danbury, Conn.); low viscosity simethicone, i.e., a simethicone having a viscosity of about 50cst or less (e.g., simethicone such as Dow Corning 200-0.5cst Fluid). Dow Corning Fluids are available from Dow Corning Corporation, Midland, Michigan. Cyclomethicone and dimethicone are described in International Cosmetic Ingredient Dictionary, 10 th edition, 2004, which is incorporated by reference as a mixture of a cyclodimethylpolysiloxane compound and a linear siloxane polymer end-capped with trimethylsiloxy units, respectively. Other non-limiting examples of volatile Silicone oils that may be used in the present invention include those available from General Electric co.

i. Essential oil

Essential oils include oils from herbs, flowers, trees, and other plants. This oil typically exists as tiny droplets between plant cells and can be extracted by several methods known to those skilled in the art (e.g., steam distillation, aroma extraction from flowers (i.e., using fat extraction), maceration, solvent extraction, or mechanical stamping). When these types of oils are exposed to air, they tend to evaporate (i.e., volatile oils). Thus, many essential oils are colorless, but over time they can oxidize and darken. Essential oils are insoluble in water, soluble in alcohols, ethers, fixed oils (plants), and other organic solvents. Typical physical properties found in essential oils include a boiling point of about 160 ℃ to 240 ℃ and a density of about 0.759 to about 1.096.

Essential oils are generally named by the plant in which the oil is found. For example, rose oil or peppermint oil is from rose or peppermint plants, respectively. Non-limiting examples of essential oils that can be used in the present invention include sesame oil, macadamia nut oil, tea tree oil, evening primrose oil, spanish sage oil, spanish rosemary oil, coriander oil, thyme oil, capsicum berry oil, rose oil, anise oil, balsam oil, bergamot oil, rosewood essential oil, cedar oil, chamomile oil, sage oil, clary sage oil, clove oil, cypress essential oil, eucalyptus oil, fennel oil, sea fennel oil, frankincense oil, geranium oil, ginger oil, grapefruit oil, jasmine oil, juniper oil, lavender oil, lemon oil, lemongrass oil, lime oil, mandarin oil, marjoram oil, myrrh oil, orange blossom oil, orange oil, patchouli oil, pepper oil, black pepper oil, orange leaf oil, pine oil, rose essential oil, rosemary oil, sandalwood oil, peppermint oil, spikenard oil, wintergreen oil, or ylang oil. It is well known that other essential oils in art skill are also contemplated as having utility in the present invention. Other essential oils known to those skilled in the art are also contemplated for use in the present invention.

j. Thickening agent

Thickeners, including thickeners or gelling agents, include substances that increase the viscosity of the composition. Certain thickeners can increase the viscosity of the composition without substantially altering the efficacy of the active ingredients within the composition. Thickeners may also improve the stability of the compositions of the present invention.

Non-limiting examples of thickeners that may be used in the present invention include hydrogenated polyisobutene or tristearin or a combination of both. Other examples include carboxylic acid polymers, crosslinked polyacrylate polymers, polyacrylamide polymers, sugars, and gums. Examples of carboxylic acid polymers include crosslinking compounds containing one or more monomers derived from acrylic acid, substituted acrylic acids, and esters and salts of these acrylic acids and substituted acrylic acids, wherein the crosslinking agent contains two or more carbon-carbon double bonds and is derived from a polyol (see U.S. Pat. No. 5,087,445; 4,509,949; No. 2,798,053; CTFAInternational Cosmetic Ingredient Dictionary, 10 th edition, 2004). Examples of commercially available carboxylic acid polymers include carbomers (carbomers), which are homopolymers of acrylic acid crosslinked with allyl ethers of sucrose or pentaerythritol (e.g., Carbopol from b.f. goodrich^TM900 series).

Non-limiting examples of crosslinked polyacrylate polymers include cationic and nonionic polymers. Examples are described in U.S. patent nos. 5,100,660; 4,849,484 No; 4,835,206 No; 4,628,078 No; 4,599,379, th.

Non-limiting examples of polyacrylamide polymers, including nonionic polyacrylamide polymers, including substituted branched or linear polymers, include polyacrylamide, isoparaffins and laureth-7, acrylamide and multi-block polymers of substituted acrylamide with acrylic acid and substituted acrylic acids.

Non-limiting examples of polysaccharides include cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof. Another example is alkyl substituted cellulose, wherein the hydroxyl groups of the cellulose polymer are hydroxyalkylated (e.g., hydroxyethylated or hydroxypropylated) to form a hydroxyalkylated cellulose, which is then further modified with C10-C30 linear or branched alkyl groups via ether linkages. Typically these polymers are ethers of C10-C30 straight or branched chain alcohols with hydroxyalkyl celluloses. Other useful polysaccharides include scleroglucan, which includes linear chains of (1-3) linked glucose units with (1-6) linked glucose units every three units.

Non-limiting examples of gums that may be used in the present invention include acacia, agar, algin, alginic acid, ammonium alginate, pullulan, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, white carbon black, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethylddextrin, sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof.

k. Additional ingredients

Non-limiting examples of additional compounds and agents that may be used in the present invention include vitamins (e.g., D, E, A, K and C), trace metals (e.g., zinc, calcium, and selenium), anti-irritants (e.g., steroids and non-steroidal anti-inflammatory agents), botanical extracts (e.g., aloe, chamomile, cucumber extract, ginkgo biloba, ginseng, and rosemary), dyes and color components (e.g., blue D & C4, green D & C5, orange D & C4, red D & C17, red D & C33, violet D & C2, yellow D & C10, yellow D & C11, and DEA-cetyl phosphate), emollients (i.e., organic esters, fatty acids, lanolin and its derivatives, vegetable and animal fats, and diglycerides and triglycerides), antimicrobial agents (e.g., triclosan and ethanol), perfumes (natural and artificial).

B. The sources of the ingredients

The ingredients of the compositions of the present invention may be obtained by any means known to those of ordinary skill in the art. In a non-limiting embodiment, for example, the components can be isolated by obtaining a source of the components. In many cases, these ingredients are also commercially available as described above. For example, magnolia extract may be obtained by any company, including Carrubba, Inc. (Milford connection), Arcadia Herbs & Alternatives (Langhorn, Pennsylvania), and Herbal Extracts Plus (Croydon, Pennsylvania). In addition, the compounds, agents and active ingredients may be purified by any technique known to those of ordinary skill in the art. Non-limiting examples of purification techniques include polyacrylamide gel electrophoresis, High Performance Liquid Chromatography (HPLC), gel or molecular sieve chromatography, and affinity chromatography. In other aspects, the compounds, agents and active ingredients can be obtained by chemical synthesis or recombinant means by conventional techniques. See, e.g., Stewart and Young, (1984); tam et al, (1983); merrifield, (1986); and Barany and Merrifield (1979), Houghten (1985).

C. Modifications and derivatives

Modifications or derivatives of the ingredients disclosed in this specification are also contemplated for use in the methods and compositions of the invention. Derivatives may be prepared by any method known to those skilled in the art and the properties of these derivatives determined for their desired properties.

In certain aspects, a "derivative" refers to a chemically modified compound that still retains the desired effect of the compound prior to chemical modification. These derivatives may have the addition, removal or substitution of one or more chemical moieties on the parent molecule. Non-limiting examples of the types of modifications that can be made to the compounds and structures disclosed in this document include the addition or removal of lower alkanes such as methyl, ethyl, propyl, or substituted lower alkanes such as hydroxymethyl or aminomethyl groups; carboxyl groups and carbonyl groups; a hydroxyl group; nitro, amino, amide and azo groups; sulfate, sulfonate, sulfenyl (sulfono), mercapto, sulfonyl, sulfoxido (sulfoxido), phosphate, phosphonyl, phosphoryl, and halide substituents. Other modifications may include the addition or deletion of one or more atoms of the atomic framework, for example, the substitution of ethyl by propyl; phenyl is substituted with a larger or smaller aromatic group. Alternatively, in cyclic or bicyclic structures, heteroatoms such as N, S or O may be substituted into the structure in place of carbon atoms.

D. Equivalents of the formula

The compositions and methods of the present invention may employ known and unknown equivalents of the ingredients discussed in this specification and claims. The equivalents may be used as substitutes for any named ingredient in the compositions of the present invention. The equivalents may also be used to add to the methods and compositions of the present invention. Those of ordinary skill in the art will be able to identify and determine acceptable known and unknown equivalents of the various components without undue experimentation.

E. Compositions of the invention

One of ordinary skill will recognize that the compositions of the present invention can include any number of combinations of the ingredients discussed in this specification. It is also contemplated that the concentration of each component may vary. In non-limiting embodiments, for example, the composition can include, in its final form, for example, at least about 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.0010%, 0.0011%, 0.0012%, 0.0013%, 0.0014%, 0.0015%, 0.0016%, 0.0017%, 0.0018%, 0.0019%, 0.0020%, 0.0021%, 0.0022%, 0.0023%, 0.0024%, 0.0025%, 0.0026%, 0.0027%, 0.0028%, 0.0029%, 0.0030%, 0.0031%, 0.0032%, 0.0033%, 0.0034%, 0.0035%, 0.0036%, 0.0037%, 0030.0030.0030.0040%, 0050.0049%, 0.0040.0040%, 0060.0040.0070.0060%, 0060.0040.0040%, 0060.0040.0070.0040%, 0060.0040.0040%, 0060.0030.0055%, 0060.0050%, 0060.0050.0075%, 0.0040.0050%, 0.0040.0040%, 0.0040%, 0060.0040.0040.0040%, 0060.0055%, 0060%, 0060.0055%, 0060.0050.0075%, 0.0050.0050%, 0.0040%, 0060.0040.0040%, 0.0040%, 0.0040.0040%, 0.0040.0040.0040%, 0060%, 0060.0040.0055%, 0060.0055%, 0060%, 0060.0050%, 0060.0040%, 0.005, 0.0075%, 0.0076%, 0.0077%, 0.0078%, 0.0079%, 0.0080%, 0.0081%, 0.0082%, 0.0083%, 0.0084%, 0.0085%, 0.0086%, 0.0087%, 0.0088%, 0.0089%, 0.0090%, 0.0091%, 0.0092%, 0.0093%, 0.0094%, 0.0095%, 0.0096%, 0.0097%, 0.0098%, 0.00 0.0099%, 0.0100%, 0200.0200%, 0.0250%, 0.0275%, 0.0300%, 0.0325%, 0.0350%, 0.0375%, 0.0400%, 0.0425%, 0.0450%, 0.0475%, 0.0500%, 2500%, 2500.0550.0550%, 0.050.050.065%, 6850.065%, 0.0070%, 0.070%, 0.05%, 0.040%, 75%, 9%, 9.9%, 0.9%, 0.0.0.50%, 0.0.0.0.0.0.0.0.0.0.0.0.0350%, 0%, 0.75%, 0.05%, 0.75%, 0.0350%, 0.75%, 0.05%, 0.75%, 0.9%, 0.75%, 0, 0.8250%, 0.8500%, 0.8750%, 0.9000%, 0.9250%, 0.9500%, 0.9750%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5.5.5%, 5.6%, 5.7%, 8%, 6.6%, 7%, 7.6%, 7%, 8.6%, 7.6%, 7%, 8.6%, 7%, 7.6%, 7%, 8.6%, 7%, 7.8%, 7%, 7.8.6%, 7%, 6%, 7%, 7.8.8%, 7%, 7.8%, 7%, 7.8.8.8%, 6%, 7%, 6%, 7%, 7.8.8%, 7, 8.9%, 9.0%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 35%, 40%, 45%, 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% or more, or any range or integer percentage derivable therein of at least one of the ingredients mentioned in the specification and claims. In non-limiting aspects, the percentage can be calculated by weight or volume of the total composition. One of ordinary skill in the art will appreciate that the concentration may vary depending on the desired effect of the composition and/or the product into which the composition is incorporated.

F. Cosmetic carrier

The compositions of the present invention may be incorporated into a variety of different carriers. Non-limiting examples of suitable carriers include emulsions (e.g., oil/water emulsions, oil/water/oil emulsions, water/oil/water emulsions, water/silicone solutions, water/silicone/water emulsions, silicone/water/silicone emulsions, water/wax emulsions, or oil/water/silicone emulsions), creams, lotions, solutions (both water and aqueous alcohols), anhydrous bases (e.g., lipsticks and powders), gels, ointments, sera, liquids, fluids, non-aerosol sprays, non-aerosol foams, or other methods known to those of ordinary skill in the art or any combination of the foregoing carriers (Remington's, 1990). Variations and other suitable vectors will be apparent to the skilled artisan and are suitable for use in the present invention. In certain aspects, it is important that the concentrations and combinations of the ingredients are selected in the following manner: the combinations are chemically compatible and do not form complexes that would precipitate from the finished product.

G. Cosmetic preparation

The compositions of the present invention may also be used in a variety of cosmetic products including, but not limited to, concealers, foundations, sunscreen products, sunless skin tanning products, moisturizers, skin creams and lotions, emollients, daily lotions, gels, ointments, night creams, lipsticks, cleansers, lotions, masks, hair products, nail products, and other known cosmetic products or applications.

H. Reagent kit

Kits are also contemplated for use in certain aspects of the invention. For example, the compositions of the present invention may be included in a kit. The kit may comprise a container. The container may include a bottle, metal tube, laminated tube, plastic tube, dispenser, pressurized container, barrier container, package, barrier, lipstick container, container with a mirror box, cosmetic tray that may contain a cosmetic composition (e.g., foundation), or other type of container, such as an injection molded or blow molded plastic container having the dispersion or composition therein or the desired bottle, dispenser, or package. The kit and/or container may include indicia on its surface. For example, the indicia may be words, phrases, abbreviations, pictures or symbols.

The container may dispense a predetermined amount of the composition. In other embodiments, the container may be squeezed (e.g., metal, laminated, or plastic tubing) to dispense the desired amount of the composition. The composition may be dispensed as a spray, aerosol, liquid, fluid or semi-solid. The container may have a spraying, pumping or squeezing mechanism. The kit may also include an application kit component and instructions for using any other dispersion or composition included in the container. The instructions may include an explanation of how the product, dispersion, or composition is to be applied, used, and maintained.

Examples

The following examples serve to demonstrate certain non-limiting aspects of the invention. It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent techniques discovered by the inventor to function well in the practice of the invention. However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention.

Example 1

Non-limiting examples of compositions of the present invention are illustrated in table 1. The composition is a cream for topical application to the skin.

TABLE 1^＊

^*The natural extract mixture contains 6.3% of Fortunella margarita (orange) extract, 63.7% of sweet orange (orange) peel extract and 30% of phenoxyethanol (preservative).

The following non-limiting procedure was used to prepare the compositions in Table 1. All phase a ingredients were added to the water in the main vessel and dispersed by propeller and oscillatory mixing. The mixture was heated to 55-60 ℃ and stirred. In a separate vessel, the phase B ingredients are heated to 55-60 ℃ or until the solids melt. The phase B mixture was added to the main vessel and mixed for about 15 minutes. The heat source is removed. Phase C ingredients were added to the main vessel and stirred in the order listed in table 1. The mixture appeared as a white, smooth, thick cream before the addition of phase D ingredients. Phase D ingredients are added to the main vessel and mixed at about 50 ℃ (note that phase D ingredients can be made into a slurry before being added to the main vessel if desired). When the phase D component was added, the mixture became thin and turned yellow. Then adding the phase E ingredients at 40-45 deg.C. Mixing was continued when the mixture was cooled to 30-35 ℃.

Example 2

Table 1 test parameters for the compositions: the compositions in table 1 were tested for efficacy on human skin. The compositions were tested on 123 women ("panelists") who had the following characteristics: (a)1/2 women are 32-45 years old, 1/2 is 46-60 years old; (b)1/3 women are dry/dry to normal skin, 1/3 is normal skin, 1/3 is combined dry/oily skin; (c) 80% of women had a marked mild/moderate "periocular edema"; and (d) 50% of women use the facial concealer product 3 or more times per week. The skin condition of panelists is summarized in table 2. The composition was applied to the periocular skin twice a day (once in the morning and once in the evening) for a total of 14 days. The panelists filled out a questionnaire asking for the tactile sensation and efficacy of the composition.

TABLE 2 (survey team member skin condition)

Results for the compositions of table 1: the panelists' responses are summarized in tables 3-16 below. The responses in table 3 relate to the feel immediately after application to the skin and the efficacy of the composition.

Table 3 (application instant)

Request item	Number of respondents	% agreement	% disagreement
				Easy to use	123	98	2
Light weight	122	98	2
				Feel soft after use	123	96	4
The eye cream commonly used by I is easier to use than the detection product	118	96	4
				The foundation used by I is easier to use than the detection product	117	96	4
No oily/greasy feeling in use	123	93	7
				Providing a cooling sensation during use	119	92	8
Has no oily/greasy feeling after use	123	91	9
				Feel smooth after use	121	90	10
Is suitable for my skin type	121	90	10
				Has silky smooth texture	121	87	13
Quickly absorb	122	84	16
				Providing a cooling sensation lasting several minutes	122	82	18
Visibly reducing the appearance of periocular edema immediately after application	115	56	44
				Immediately after application, visibly reduces the appearance of periocular edema to a minimum	115	50	50
Visibly reducing the appearance of dark circles to a minimum immediately after application	118	49	51
				Visibly reducing the appearance of dark circles immediately after application	117	44	56

Does not include "i did not use/do not know"

The panelists' responses in table 4 relate to the efficacy of the composition after two weeks of use.

TABLE 4 (after two weeks of use)

Request item＊	Number of respondents	% agreement	% disagreement
				Refreshing my ocular region	121	88	12
Softening the appearance of periocular edema	115	80	20
				Make eye region glow	120	78	22
Visual reduction of the appearance of periocular edema to a minimum	112	75	25
				Make the eye region look full of vitality	119	75	25
Softening the appearance of the dark circles	118	74	26
				Improving the appearance of puffiness around the eyes	114	74	26
Visibly reduced the appearance of periocular edema	113	73	27
				Restoring vitality to eye region	122	73	27
Eliminating the appearance of puffiness around the eyes	112	70	30
				Softening the appearance of periocular sag	102	70	30
Visibly minimizing the appearance of dark circles	118	69	31
				Making eye region look younger	121	69	31
Improving the appearance of dark circles	118	68	32
				Brighten my eye region	121	68	32
Visibly reducing the appearance of dark circles	117	66	34
				Improving the appearance of periocular sag	103	66	34
Make the eye region look full of vitality	120	66	34
				Appearance of eliminating black eye	118	64	36
Visibly reduced eye drop appearance	102	63	37
				Visibly minimize periocular prolapse	102	61	39
Appearance for eliminating eye drop	103	56	44

The responses in table 5 relate to the feel immediately after application to the skin and the efficacy of the composition. The answers are organized by age of the panelists.

TABLE 5 (age-application immediate)

The answers in table 6 relate to the efficacy of the composition after two weeks of use. The answers are organized by age of the panelists.

TABLE 6 (age-after two weeks of use)

The panelists' responses in table 7 relate to the feel immediately after application to the skin and the efficacy of the composition. Responses were organized by panelists with mild/moderate periocular edema and panelists without periocular edema.

TABLE 7 (periocular edema-immediate after application)

The panelists' responses in table 8 relate to the efficacy of the composition after two weeks of use. Responses were organized by panelists with mild/moderate periocular edema and panelists without periocular edema.

Table 8 (edema around the eyes-after two weeks of use)

The panelists' responses in table 9 relate to the feel immediately after application to the skin and the efficacy of the composition. Responses were organized by panelists with and without light dark circles.

Watch 9 (Black eye-applied immediately)

The panelists' responses in table 10 relate to the efficacy of the composition after two weeks of use. Responses were organized by panelists with and without light dark circles.

Watch 10 (Black eye-after two weeks use)

The panelists' responses in table 11 relate to the feel immediately after application to the skin and the efficacy of the composition. The answers were organized by panelists who used concealer products and panelists who did not.

Watch 11 (use concealer-application-immediate)

The panelists' responses in table 12 relate to the efficacy of the composition after two weeks of use. The answers were organized by panelists who used concealer products and panelists who did not.

Watch 12 (use concealer-after two weeks)

The panelists' responses in table 13 relate to the feel immediately after application to the skin and the efficacy of the composition. Responses were organized by panelists with dry, normal and oily skin.

Watch 13 (skin type-application immediate)

The panelists' responses in table 14 relate to the efficacy of the composition after two weeks of use. Responses were organized by panelists with dry, normal and oily skin.

Watch 14 (skin type-after two weeks of use)

The panelists' responses in table 15 relate to the feel immediately after application to the skin and the efficacy of the composition. The answers are organized by panelists with light, medium and dark skin tones.

Watch 15 (skin color-application instant)

"bright" means very bright and bright; "medium" means light to medium, and medium to dark; "dark" is either dark or very dark

The panelists' responses in table 16 relate to the efficacy of the composition after two weeks of use. The answers are organized by panelists with light, medium and dark skin tones.

Watch 16 (skin color-after two weeks use)

"bright" means very bright and bright; "medium" means light to medium, and medium to dark; "dark" is either dark or very dark

Example 3

Three ingredients useful in the compositions of the present invention were tested to determine their effect on melanin production and tyrosinase activity. Three components are CLEILYS^TMAscorbic acid glucoside and UNINTANU 34^TM. The materials and methods used to perform these tests and the corresponding data are as follows.

Materials and methods: human melanocytes from moderately pigmented donors were purchased from Cascade biologics (Portland, Oregon). Human dermal fibroblasts were purchased from Cambrex (Rockland, ME). To determine the optimal concentration of test substances for use in a whitening assay, these substances were first tested in a proliferation assay using human dermal fibroblasts. The highest non-interfering concentration was determined for each test substance and further 5-fold dilutions were prepared for melanocyte culture.

The following assay was used to determine the effect of each substance on melanin production. Melanocytes were seeded in fully supplemented 254 medium (Cascade) in 96-well plates and test substances were added after 24 h. Cells were grown for 6 days with one change of growth medium. At the end of the experiment, the cells were lysed with a cellytic mammalian Cell Lysis/Extraction Reagent (Sigma, St. Louis, Mo.) and the melanin was dissolved in 2N NaOH. Melanin content was determined spectrophotometrically at 405nm using Bradford reagent (Sigma, st.louis, MO) and normalized to the total protein content from the same culture. Kojic acid was used as a positive control. Cell culture was monitored on a Nikon Eclipse inverted microscope.

Tyrosinase activity was determined by a modified Pomerantz method (Biophys Res Commun, 1964). Mushroom tyrosinase (Sigma #3212816630) enzyme stock was 5U/well (25U/ml). Substrate (I-DOPA, Fisher Scientific, Pittsburgh, Pa.) stock solution was 20 mM. Working solutions were prepared in PBS for each assay. The reaction mixture consisted of 50. mu.l of 20mM I-DOPA and 10. mu.l of undiluted test sample. The reaction was started by adding tyrosinase. The assay was performed in 96-well flat-bottomed microplates (Fisher #0720087) and read at 490nm after 5,10 and 20 min.

As a result: the results of the melanin production and tyrosinase inhibition assays are summarized below in table 17. These results demonstrate that the test substance can inhibit melanin production and tyrosinase activity.

TABLE 17 (melanin production assay)

Detecting substance	Melanin inhibition in cells	Dilution factor	Tyrosinase inhibition assay (5min)	Tyrosinase inhibition assay (10min)	Tyrosinase inhibition assay (20min)
						H20	100％	-	100.0	100.0	100.0
Kojic acid	83％	200μM	39.0	35.5	33.1
						CLERILYSTM	60％	1-100	62.4	45.9	34.3
Ascorbic acid glucoside	75-65.5％	1/25-1/125	33.8	30.6	30.1
						UNINONTANU34TM	60.5％	1/100	9.4	6.5	5.0

All of the compositions and/or methods disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure. While the compositions and methods of this invention have been described in terms of specific embodiments, it will be apparent to those of skill in the art that variations may be applied to the compositions and/or methods and in the steps or in the sequence of steps of the methods described herein without departing from the concept, spirit and scope of the invention. More specifically, it will be apparent that certain agents which are both chemically and physiologically related may be substituted for the agents described herein while the same or similar results would be achieved. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims.

Reference to the literature

The following references are specifically incorporated by reference herein to provide exemplary, procedural or other details supplementary to those disclosed herein.

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Claims (8)

1. Use of a composition comprising magnolia biondii flower extract, hops extract, hesperidin methyl chalcone, centella asiatica extract, dipeptide valyl-tryptophan, palmitoyl tetrapeptide-3, corylus avellana bud extract, cucumis sativus extract, morus alba extract, hibiscus sabdariffa flower extract, vitis vinifera extract, ascorbyl glucoside, lemon extract, avena sativa kernel extract, hydrolyzed soy protein, aniseed myrtle extract, illicium simonsii leaf extract, artemisia nana extract, and pomelo fruit extract in the manufacture of a medicament or cosmetic for reducing the appearance of black circles, puffiness, or drooping in the periorbital region of human skin.

2. The use of claim 1, wherein the composition further comprises an antioxidant and a humectant.

3. The use of claim 2, wherein the antioxidant is vitamin E or tocopherol acetate.

4. The use of claim 2, wherein the humectant is petrolatum.

5. The use of claim 4, wherein the composition further comprises water.

6. The use of claim 1, wherein the grapefruit fruit extract is a grapefruit peel extract.

7. The use of claim 1, wherein the composition further comprises an antioxidant, a humectant, and water.

8. The use of claim 7, wherein the antioxidant is vitamin E or tocopherol acetate and the humectant is petrolatum.