HK1038163B - Beverage for increasing the body's capacity to break down alcohol - Google Patents

Description

The invention relates to the use of a soft drink composition containing fructose to increase the body's ability to break down alcohol.

The invention also relates to a soft drink, a syrup and a dry substance to increase the body's alcohol-absorbing capacity.

The absorption of alcohol (ethanol) occurs both from the stomach and intestines. The absorption is usually completed in about an hour, but in the sober state earlier, in case of heavy stomach/intestinal filling, the absorption may also be delayed. Due to the oil/water partition ratio of 0.04, a rapid distribution of alcohol occurs in the body water.

The enzyme ADH acts as a catalytic center for zinc and is NADH-dependent. In addition, small amounts of alcohol are also further oxidized to acetaldehyde and acetic acid via the P450-dependent monooxygenase system. Small amounts (0.5%) are directly glucuronidated, columns of sulfuric acid are coupled and separated with the tricarboxylic acid. The source of the enzyme ADH is supplied by the enzyme Aldehydroxydehydrogenase.

A soft drink to lower blood alcohol levels is described in EP 0 205 634 A or DE-C1 4 431 178 and contains water, fructose, ascorbic acid and flavourings and/or citric acid and/or quinine.

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WO 87/01285 A reveals a therapeutic composition for the treatment of acute and/or chronic symptoms associated with excessive alcohol intake. This composition includes an analgesic, nicotinamide and/or NAD. The composition may include fructose, water-soluble vitamins, an antacid, an electrolyte substitute, e.g. potassium, sodium, magnesium or calcium, trace analgesics, e.g. zinc ions, an antihistamine component, alkaloids, caffeine and other additives, e.g. flavorings and sweeteners. It is particularly important for the effect of the composition that the fructose or NAD composition of an analgesic be reduced to at least 7% for patients with severe asthma and may lead to more severe side effects, such as increased symptoms and increased potency of the drug.

CN code 1 090 146 A refers to a health drink containing, inter alia, water-soluble vitamin B, fructose, trace elements, vitamin A, vitamin C, amino acids and having an anti-residue toxicity effect on alcohol.

The CR 9 500 456 B1 describes a drink against the effects of alcohol, which contains, among other things, fructose at 1-10% and vitamin B2 at 0,05-0,5% and a filtrate from a fermentation with lactic acid bacteria. The fermentation is carried out under certain conditions (30-40°C, pH 9-9.5, 50 to 100 hours). The production of this drink is relatively time consuming, which usually also affects the price of the drink.

JP 61162159 A reveals a drink to accelerate the reduction of blood alcohol, where the drink contains fructose, vitamin C and quinine or quinine derivatives.

DE 197 20 818 A describes a composition for the promotion of performance in sport, comprising various electrolytes, vitamins and trace elements with and without L-methionine in dry powder or dissolved in water.

EP 0 652 012 A describes a composition designed to facilitate and promote the passage of substances through the blood-brain barrier, this composition being a combination of sugars and amino acids and can be used for a variety of treatments. This document provides a basic composition. This basic composition may include various additional additives depending on the treatment: For example, it is stated that the composition can be used to restore motor functions after excessive alcohol consumption or to treat alcoholics, where the basic composition is described in Example 1 as L-arginine and/or hydroxymacromolecules and proline.

Derwent Publ. XP002130552 & JP 08 073350 A (Itoen KK) is a compound for the treatment of Alzheimer's disease, Parkinson's disease, senility and neurological disorders, the compounds to be administered in which include fruit sugar, caffeine, tein, nicotinamide, inositol and taurine.

Derwent Publ. XP002130553 & CN 1 126 588 (LIHH-I) is concerned in general with a health drink containing taurine, inositol, vitamin B, caffeine, sorbitol, sugar and other ingredients.

According to EP 0 583 852 A, a composition of bottled pumpkin powder is described as a food or beverage which is intended to mimic the characteristic smell and taste of bottled pumpkin concentrates.

WO 97/02830 A describes a method for the prevention of otitis media in infants and young children, the composition to be administered including fructooligosaccharides, fructosane, xylooligosaccharides and galactooligosaccharides.

The purpose of the present invention is therefore to provide a use of a soft drink composition which significantly increases the rate of alcohol breakdown in the body, also compared to fructose (vitamin C) mixtures, without adding enzymes or NADH+/NAD, so that the shelf life of the product is not limited. The composition is furthermore to exclude substances which cause side effects and which, if frequently ingested, may cause harm to health.

The use of the method described at the outset is characterised by the fact that the composition of the soft drink includes, in addition to fructose, one or more components of the vitamin B complex and taurine. This surprisingly increases the rate of alcohol breakdown in the body very effectively, preferably by at least 45% (see examples). The added fructose can be present in any known form and also be phosphorylated. The composition of the invention is highly stable and therefore can be stored for a longer period.

Vitamin B complex is defined as all water-soluble vitamins except vitamin C. In many cases they are components of coenzymes (see below) that are active in redox reactions and thus directly or indirectly promote the reaction of alcohol dehydrogenase. In particular, the activation of the tricarboxylic acid cycle by the B-complex vitamins is an essential property of the present invention, since it has been shown that activation of the citrate cycle can also significantly increase the rate of aclohal degradation.

Taurine is the name for 2-aminoethanesulfonic acid and is found in almost all mammalian species. Taurine plays an important role in the development of the central nervous system (CNS) and influences transport processes of 2-value metal ions, e.g. as a calcium, magnesium and zinc modulator. Taurine continues to act as an inhibitory neurotransmitter or neuromodulator. Relatively high concentrations of taurine are found in the CNS, retina and heart.

Taurine has also been shown to support and accelerate the breakdown of alcohol in the body. By adding taurine to a composition that includes fructose and at least one vitamin B complex component, a drink is made available that breaks down alcohol in the body extremely effectively. These (at least) three components, when contained in a composition, have a surprisingly synergistic effect, i.e. the components are in a functional interaction with each other and have a combinatory effect that exceeds the sum of their individual effects. The combination of these (at least) three components has an extremely powerful breakdown effect.

This drink can also be given as a concomitant treatment in particularly extreme cases, such as alcohol poisoning with coma, circulatory failure, convulsions, etc.

Another use is in the treatment of alcoholics who have chronic symptoms such as chronic loss of electrolytes and fluids, tremors, fatigue, coordination problems, physical weakness and mental problems such as depression, hallucinations, etc.

A particularly favourable use is given by the fact that the composition includes fructose and vitamin B complex components in a weight ratio of 10:1 to 10,000:1, in particular from 100:1 to 5,000:1, particularly preferably from 1,000:1. Even the two extreme ratios of 10:1 and 10,000:1 increase the rate of breakdown of blood alcohol, but the ratio of fructose to vitamin B complex components of 1,000:1 has been shown to be optimal for accelerated alcohol breakdown in the body.

Preferably, the components of the vitamin B complex are selected from vitamin B1, B2, B6, B12, biotin, niacin, pantothenic acid, folic acid, adenine, choline, adenosine phosphate, orotic acid, pangamic acid, carnitine, 4-aminobenzoic acid, myo-inosite, lipoic acid and/or amygdalin. Vitamin B1, also known as thiamin, is converted in the body to thiaminpyrophosphate, a coenzyme in a series of reactions in which C-C bonds can be cleaved. It can also be added as thiaminx chloride, among others. Vitamin B2, also called riboxal, is absorbed in the small intestine, converted to n-amino (Famino) and converted to pyridoxine (Famino) and other enzymes, including the pyridoxine (Famino) and coenzyme pyridoxine (Famino), which are also found in the coenzyme pyridoxine, and in the coenzyme pyridoxine (Famino), which is found in the coenzyme pyridoxine, and in the coenzyme pyridoxine, which is found in the coenzyme pyridoxine, and in the coenzyme pyridoxine.It is a component of pyridoxal-5 phosphate, which is a cofactor in glycogen breakdown and amino acid metabolism, e.g. as a coenzyme of decarboxylase. Preferably, this substance is added to the drink composition in the form of pyridoxine hydrochloride. Vitamin B12, also called cyanocobalamin, has a complex structure and is a component of cobalamin coenzymes, with e.g. methylcobalamin and cobalamide playing a role in hydrogen migration rearrangements, among others. Biotin, also called vitamin B7 or H, is covalently bound to carboxylases, niacin, an umbrella term for nicotinic acid and nicotinamide phosphate, as a component of NADP and its hydrogen excess is the most important in the body and has a protective effect on the body.Pantothenic acid, also known as vitamin B3 or B5, has a precursor function to coenzyme A, which occupies a central position in metabolism. Folic acid, or vitamin M, B9 or Bc, is a component of coenzyme tetrahydrofolate. These examples (to name a few) clearly show the important role that vitamin B complex components play in metabolism.

The composition of the soft drink preferably includes the vitamin B complex components in the following parts by weight, in relation to 15 000-20 000 parts by weight of total dry matter: vitamin B1 to 0,1-10, in particular, vitamin B2 to 0,1-10, in particular, 1,5, vitamin B6 to 0,1-10, in particular, 1,5, biotin to 0,01-1, in particular, 0,1, niacin to 0,1-100, in particular, 10-30, pantothenic acid to 0,1-100, in particular, 1-10, vitamin B12 to 0,0001-0,1, in particular, 0,001-0,01, and/or folic acid to 0,01 in particular.

A particularly favourable result is obtained when the composition further includes minerals, especially magnesium and/or potassium and/or zinc. Since minerals are important for a number of metabolic processes in the body, the addition of this group of substances to the composition of the drink is important, with several different minerals being added. Specifically, zinc is a component of alcohol dehydrogenase, potassium and magnesium play a major role in metabolism, among others magnesium is involved in all enzyme reactions catalyzed by ATP. Minerals can be added in combination with other food additives, e.g. magnesium glyphosate, calcium nitrate (sink regulator), acetic acid (hydroxy nitrate), and magnesium nitrate (acetic acid), which could not be described directly in the first place until the discovery of the drug ADH (calcium nitrate), and therefore only some examples of this could be described in the first place.

Preferably the composition includes magnesium, potassium and/or zinc in the following proportions by weight, in relation to 15 000-20 000 total dry matter: magnesium to 10 000 parts, especially 100, potassium to 10 000 parts, especially 100, zinc to 0,1-100 parts, especially 1-10 again these quantity figures are only guidelines, since different ratios give very good results.

It is also beneficial if the composition includes amino acids, especially L-glutamine and/or L-arginine. Amino acids play an important role in the various metabolic processes of the human body, so the addition of amino acids generally has a positive effect on the body's alcohol breakdown. In particular, L-glutamine and L-arginine in particular have a promoting effect on alcohol breakdown, being added preferably at the following weight proportions, in relation to 15 000-20 000 total dry matter weight proportions: L-arginine at 20 000-100, especially 200, L-glutamine at 10 000-100, especially These amounts achieved optimal alcohol breakdown results.

Furthermore, it is beneficial if the composition includes caffeine, especially 0.1-100, preferably 10-50, parts by weight, in relation to 15,000-20,000 parts by weight of total dry matter.Caffeine (thein, guaranine, trimethylxanthin) has a stimulating effect on the CNS, stimulates cardiac activity, metabolism and respiration, increases blood pressure, body temperature and blood circulation rate, the blood vessels in the brain expand while narrowing in the intestines.This results in a suppression of fatigue, temporary improvement in work performance and mood elevation and counters the effects of alcohol.

Anthocyanins are commonly used in the food industry as colouring agents, which can be red, blue or violet depending on pH or complex formation with metals.

Furthermore, it is particularly advantageous if the composition contains 10 to 1000, preferably 100 parts by weight of taurine, in relation to 15 to 20 000 parts by weight of total dry matter.

For optimal alcohol degradation, it is desirable that the composition, expressed as 100 g/l of dry matter, comprise 0,0001-0,1% each, in particular 0,001-0,01%, vitamin B1, vitamin B2 and/or vitamin B6, 0,000001-0,001, in particular 0,00001-0,0001% each, vitamin B12, in particular 0,00001-0,01%, in particular 0,0001-0,001%, biotin and/or fluorine, in particular 0,001-1%, in particular 0,01-0,1%, niacin, pantothenic acid, zinc and/or anthocyanins, in particular 0,01-10%, in particular 0,1-1%, magnesium, potassium, L-glutarol, caffeine and/or taurine, in particular 0,01-100%, in particular 0,1-10%, L-arginine and/or 50-99,99%, in particular 95-98%, fructose. However, different combinations have been shown to be effective in increasing the alcohol content mentioned above.

Another advantageous use is the addition of other vitamins, especially vitamin C, to the composition, which allows all the vitamins commonly used in the food industry, in the usual concentrations. Vitamin C is not necessary to increase the rate of alcohol breakdown, but can be added for health reasons (e.g. to support the immune system), as is usually the case with beverages, especially fruit juices.

Preferably, the composition includes other additives, in particular flavourings, preservatives, colours, antioxidants, electrolytes, enzymes, plant extracts, glycerin phosphates, acid regulators and/or acidifiers, especially fruit acids. These substances generally have no particular influence on the rate of alcohol breakdown, but are only added for food-technical reasons, as in any food and drink. Acid regulators may also be used as anti-acid agents to counteract excessive acidification in the stomach, especially after excessive ingestion.

Other additives may include histamines, which counteract allergic reactions in some people to various ingredients in alcoholic beverages, and, at least in low concentrations, quinines, which are also beneficial and accelerate alcohol breakdown and are muscle relaxants.

A particularly preferred use is achieved by the addition of additional sugars and/or sweeteners to the composition of the soft drink. Both artificial and natural sweeteners can be added to the sweetening of the composition. In addition to fructose, any sugar can be added, such as glucose, galactose, lactose, etc. This gives the drink an even sweeter taste, in addition to the addition of fructose.

The use of the invention of the type mentioned at the outset is furthermore preferably characterised by the fact that the soft drink includes a liquid foodstuff in addition to the invention of the composition described above. Dissolving/suspending the invention of the composition with the liquid foodstuff will produce a liquid drink to reduce the blood alcohol level. The liquid is primarily water, with both carbonated and non-carbonated water being used. However, any other body-friendly liquid, such as fruit juices, milk, coffee, and similar, can be added. Furthermore, it is also possible to make an alcohol-depleting drink.

The use of a composition which is available as a syrup or as a dry substance is also provided for in accordance with the invention. The syrup or dry substance can be diluted or dissolved with any body-friendly liquid to obtain a drink with the best possible taste. The dry substance can be prepared, for example, in the form of a powder or tablet, so that it is easily handled and filled in portions and can be easily taken anywhere and used - in isolation.

It is self-evident that the invention relates to any other possible consistency, the alcohol-degrading composition containing at least fructose and vitamin B complex components being naturally absorbable by drinking, chewing, sipping, swallowing, to name but a few examples.

The following example and figures, to which it is not limited, will explain the invention further. Figures 1-3 show in detail a verum test and Figures 4-6 a placebo test, wherein the alcohol content in the promille in time (min) is shown as an alcohol curve and the individual results are listed in the table (E=drink of the invention, S=snaps, B=beer, W=wine, C=Coca Cola, M=mineral, -=5: structure).

Example:

The following substances were added to 250 ml of water: 15 mg of niacin, 5 mg of pantothenic acid, 1.6 mg of vitamin B6, 1.5 mg of vitamin B2, 1.1 mg of vitamin B1, 0.1 mg of folic acid, 0.1 mg of biotin, 2 mg of vitamin B12, 200 mg of L-arginine, 100 mg of L-glutamine, 100 mg of taurine, 100 mg of K, 5 mg of Zn, 10 mg of anthocyanins, 30 mg of caffeine, 17.500 mg of fructose.

A group of 10 participants were given the same amount and type of alcohol (beer and liquor) over a period of 2.5 hours. 5 people were given 250 ml of the drink of the invention (verum group) at 0, 60, 120 and 180 minutes, 5 people 250 ml of a Coca-Cola drink (control group). The alcohol levels were measured at intervals of 15 minutes over a period of 4 hours. The following day was spent in complete abstinence from alcohol. The next day the preliminary experiment was repeated, but this time the control group received the drink of the invention and the Verum group the Coca-Cola drink.

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Results: The average rate of alcohol degradation was 0.13% per hour in the control group and 0.19% per hour in the verum group, corresponding to an average increase in the rate of alcohol degradation of the beverage of the invention of 46%.

Claims (20)

1. The use of a refreshing drink composition containing fructose for increasing the alcohol degradation capacity of the body, characterised in that the composition further comprises one or more components of the vitamin B complex as well as taurine.
2. The use according to claim 1, characterised in that the composition comprises fructose and vitamin B complex components in a weight ratio of from 10:1 to 10,000:1, in particular from 100:1 to 5,000:1, particularly preferred from 1,000:1.
3. The use according to claim 1 or 2, characterised in that the components of the vitamin B complex are selected from vitamin B1, B2, B6, B12, biotin, niacin, pantothenic acid, folic acid, adenine, choline, adenosine phosphate, orotic acid, pangamic acid, carnitine, 4-aminobenzoic acid, myo-inositol, liponic acid and/or amygdaline.
4. The use according to any one of claims 1 to 3, characterised in that the composition comprises the vitamin B complex components in the following parts by weight, based on a total of 15,000-20,000 parts by weight of the dry substance: vitamin B1, 0.1-10, in particular 1; vitamin B2, 0.1-10, in particular 1.5; vitamin B6, 0.1-10, in particular 1.5, biotin, 0.01-1, in particular 0.1; niacin 0.1-100, in particular 10-30; pantothenic acid, 0.1-100, in particular 1-10; vitamin B12, 0.0001-0.1, in particular 0.001-0.01; and/or folic acid, 0.01-10, in particular 0.1.
5. The use according to any one of claims 1 to 4, characterised in that the composition further comprises mineral substances, in particular magnesium and/or potassium and/or zinc.
6. The use according to claim 5, characterised in that the composition comprises magnesium, potassium and/or zinc in the following parts by weight, based on a total of 15,000-20,000 parts by weight of dry substance: magnesium, 10-1,000, in particular 100; potassium: 10-1,000, in particular 100; zinc, 0.1-100, in particular 1-10.
7. The use according to any one of claims 1 to 6, characterised in that the composition comprises amino acids, in particular L-glutamine and/or L-arginine.
8. The use according to claim 7, characterised in that the composition comprises L-arginine and/or L-glutamine in the following parts by weight, based on a total of 15,000-20,000 parts by weight of dry substance: L-arginine, 20-2,000, in particular 200; L-glutamine, 10-1,000, in particular 100.
9. The use according to any one of claims 1 to 8, characterised in that the composition comprises caffeine, in particular 0.1-100, particularly preferably 10-50 parts by weight, based on a total of 15,000-20,000 parts by weight of dry substance.
10. The use according to any one of claims 1 to 9, characterised in that the composition comprises anthocyans, in particular 0.1-100, particularly preferably 10 parts by weight, based on a total of 15,000-20,000 parts by weight of dry substance.
11. The use according to any one of claims 1 to 10, characterised in that the composition comprises 10-1,000, preferably 100, parts by weight of taurine, based on a total of 15,000-20,000 parts by weight of dry substance.
12. The use according to any one of claims 1 to 11, characterised in that, based on 100 parts by weight of dry substance, the composition comprises 0.0001-0.1%, in particular 0.001-0.01%, each of vitamin B1, vitamin B2 and/or vitamin B6, 0.000001-0.001, in particular 0.00001-0.0001% of vitamin B12, 0.00001-0.01%, in particular 0.0001-0.001%, each of biotin and/or folic acid, 0.001-1%, in particular 0.01-0.1%, each of niacin, pantothenic acid, zinc and/or anthocyans, 0.01-10%, in particular 0.1-1%, each of magnesium, potassium, L-glutamine, caffeine and/or taurine, 0.01-100%, in particular 0.1-10%, of L-arginine, and/or 50-99.99%, in particular 95-98% of fructose.
13. The use according to any one of claims 1 to 12, characterised in that the composition comprises further vitamins, in particular vitamin C.
14. The use according to any one of claims 1 to 13, characterised in that the composition comprises further additives, in particular flavoring agents, preserving agents, coloring agents, antioxidants, electrolytes, enzymes, plant extracts, glycerolphosphates, acid regulators and/or acidifiers, in particular fruit acids.
15. The use according to any one of claims 1 to 14, characterised in that the composition comprises further sugars and/or sweeteners.
16. The use of a refreshing drink for increasing the alcohol degradation capacity of the body, characterised in that in addition to the composition as defined in any one of claims 1 to 15 it further comprises a liquid foodstuff.
17. The use according to any one of claims 1 to 15, characterised in that the composition is provided as a syrup.
18. The use according to any one of claims 1 to 15, characterised in that the composition is provided as a dry substance.
19. The use of a syrup for increasing the alcohol degradation capacity of the body, characterised in that it comprises a composition as defined in any one of claims 1 to 15.
20. The use of a dry substance for increasing the alcohol degradation capacity of the body, characterised in that it comprises a composition as defined in any one of claims 1 to 15.