HK1027718A - Nutritive composition for cardiovascular health - Google Patents

Description

Nutritional composition for cardiovascular health

Cross reference to related application

This invention is a partial renewal application of copending non-transient application No. 08/661, 088 filed on 10.6.1996. Background of the invention

1. Field of the invention

The present invention provides a novel nutritional composition, particularly a nutritional composition containing fish oil, garlic, rutin, capsaicin, vitamin a (beta carotene), vitamin E, vitamin C, selenium and selected juice concentrates, which is useful for lowering triglycerides in human serum. Cholesterol and Low Density Lipoprotein (LDL), lowering blood pressure, and increasing High Density Lipoprotein (HDL) levels in human serum.

2. Background of the invention

In recent years, the scientific literature has provided strong evidence to show an unsuspecting relationship between nutrient compositions (such as vitamins, minerals, fish oils and plant extracts) and cardiovascular disease. For those at high risk for cardiovascular disease, it is known that an appropriate reduction of their serum levels of high cholesterol, triglycerides, LDL is important to reduce the risk of heart disease. It is also known that increasing HDL levels can also be provided as a means to significantly reduce the risk of heart disease.

Cardiovascular disease, which is formed by arterial plaque, is known to be a major cause of illness and death in humans. Arterial plaque formation is mainly due to the formation of precipitated substances by oxidized low density lipoprotein (O-LDL). The formation of O-LDL plaques in arteries is considered to be a factor in the development of ischemic heart disease. Free radical oxides oxidize LDL to its harmful form, i.e., O-LDL. Many of the free radical oxides described are derived from naturally occurring sources such as sun exposure, metabolism of certain nutrients, exercise, or are frequently observed in patients with diabetes and hypertension, and free radical "scavenger" compounds such as vitamin A, E, C and selenium are believed to react with these oxides and render them unavailable for oxidation. The inhibitory effect of these antioxidants thus inhibits the formation of O-LDL, thereby reducing the deposition of arterial plaque in the blood vessel. Conversely, the presence of HDL in the body is considered to be a great health benefit. In particular, HDL is known to be a more soluble form of lipoprotein, so its presence does not significantly contribute to the formation of arterial plaque. Furthermore, known HDL can absorb plaque material and, therefore, can directly reduce arterial plaque content. 3. Description of the Prior Art

Essential Fatty Acids (EFAs) are naturally unsaturated fatty acids with a chain length of 18, 20 or 22 carbon atoms. These EFAs cannot be synthesized by the body, and thus the EFAs must be taken from the diet. Two eicosapentaenoic acids (EPA) and docosahexaenoic acid (DHA) belonging to the EFA family are generally present in fish oils. Epidemiological observations have shown that fish oil reduces platelet aggregation and serum triglycerides and thus may reduce the risk of myocardial infarction, hypertension, atherosclerosis and certain types of cancer. [ Gerster, h., lnat.j.vit.nutr.res., 65: 3-20(1994). In particular, EPA and DHA from fish oils have been shown to play an important structural role in most cell membranes and to influence cell membrane fluidity by reducing systemic viscosity and increasing the surface of the red blood cells for tortuosity and deformability (Gerster, cited above). In addition, EFAs such as EPA and DHA are known as precursors of eicosanoid derivatives (eicosaniod). Eicosanoid derivatives are a broad class of compounds that include prostaglandin derivatives (prostanods) such as prostaglandins and thromboxan, leukotrienes and hydroxy fatty acids. Eicosanoid derivatives are known to affect platelet aggregation, vessel wall permeability and tension, blood pressure and inflammatory immune responses (Gerster, cited above).

Supplementation of fish oil in the diet is known to have other beneficial health effects. Glycogen storage is a genetic disease and is often complicated by severe hyperlipoproteinemia and hypercholesterolemia, thus increasing premature atherosclerosis and cardiovascular disease. Reports have reported that: patients with glycogen storage disease who received 10g of fish oil for 3 months had a significant decrease in serum triglyceride (-49%), cholesterol (23%), LDL (-40%), and a significant increase in serum HDL (+ 30%), (Levy, e., et al, i.am.j.clin.nutr.57: 922-29 (1993)).

Garlic powder has not been recognized as having many valuable benefits to the human body, and it can be used as a prophylactic against cardiovascular diseases. For example, daily garlic intake results in decreased lipid levels in human serum, increased fibrinolysis and increased tissue plasminogen activator (t-PA) activity, such as decreased plasma fibrinogen viscosity, which may reduce the likelihood of cardiovascular disease. (Brosche, T. et al, British J.Clin.Practice, supplement 69: 12-19 (1990); kiesewetter H. et al, British J.Clin.Practice, supplement 69: 24-29 (1990); furthermore, daily intake of garlic is known to reduce total cholesterol and triglyceride levels in human serum, as well as to reduce peripheral vascular diastolic blood pressure (Auer, W. et al, British J.Clin.Practice, supplement 69: 3-6 (1990)).

Flavonoids are secondary metabolites present in edible plants and plant-derived foods. Flavonoids are widely recognized as having anti-allergic, anti-inflammatory, anti-viral, anti-proliferative, and anti-carcinogenic activities. [ Manach, C, et al J.Nutr, 125: 1911-22(1995)]. Of the flavonoids, flavonols are the most abundant in plants, possessing most of these biological properties [ Manach, cited above ]. Flavonoids occur naturally as O-glycosides, typically with a sugar moiety attached at the C-3 position. Rutin, a typical glycoside form of quercetin, is the most abundant flavonol-like content in fruits and vegetables.

Capsaicin is the major chemical entity in plants of the capsicum genus, including dried pepper, paprika, and capsicum. Capsaicin is actually a homogeneous compound belonging to the class of straight-and branched-chain alkyl vanillylamides. The antimicrobial and analgesic properties of capsaicin have been known for centuries. In addition, products containing capsaicin have been used to treat rheumatoid arthritis, osteoarthritis, diabetic neuropathy, post-herpetic neuralgia, post-mastectomy pain syndrome, cluster headaches, and sympathetically reflex syndrome (Cordell, G. and Araujo, O., Ann. pharm., 27: 330-36 (1993)).

Certain vitamins and minerals, antioxidants and plant extracts are generally known to have health benefits. For example, many benefits of antioxidants have been known for many years. Antioxidants are chemical substances that can react with free radicals, such as hydroxyl radicals, to protect certain biological systems. Removal of free radicals in the body has been thought to increase human longevity, in particular the presence of antioxidants including superoxide dismutase (SOD), carotenoids, alpha-tocopherols and uric acid, which are believed to be positively associated with resistance to spontaneous autoxidation of tissues in the mammalian body and oxidative damage to DNA [ Cutler, r., am.j.clin.nutr., 53: 3735-9S (1991) ]. Antioxidants are also known to limit free radical damage to healing brain tissue. This result is shown by a method of resuscitating the brain using vitamins such as vitamin A, E and C or selenium (see Klatz et al, U.S. Pat. No.5, 149,321 and PCT application PCT/US 92/06681).

In addition to their antioxidant activity, vitamins A, C and E are also well known for their other beneficial health effects. For example, vitamin E is known to help maintain an appropriate blood glucose value. In another example, vitamin C is known to play a necessary role in the integrity of connective and structural tissues in the body. Vitamin a has effects in maintaining good vision, and in growth and development. Therefore, proper supplementation of these vitamins is essential to maintain optimal health. When vitamin A, E, C and selenium are used in combination with certain active peptides, vitamin A, E, C and selenium are believed to be useful as a means of inhibiting or preventing the cross-linking of gliadins in the skin of the body (see Geoffrey et al, PCT application WO 90/06102).

While the use of compositions is known in a manner to reduce the risk of developing cardiovascular disease, the present invention includes a novel composition consisting of fish oil, garlic, rutin, capsaicin, vitamin A, vitamin C, vitamin E and selenium, and juice concentrate, which achieves this goal. Such compositions are needed in the art for the prevention or treatment of cardiovascular diseases and disorders.

Summary of the invention

The present invention relates to the use of nutritional supplement compositions to overcome nutritional deficiencies associated with normal mammalian diets. This gives the composition of the invention: combining fish oil, garlic powder, rutin, capsaicin, vitamin A, vitamin C, vitamin E, selenium, and one or more juice concentrates. In particular, the present invention relates to the daily administration of fish oil, garlic powder, rutin, capsaicin, vitamin A, vitamin C, vitamin E, selenium and one or more juice concentrates in separate formulations, or a combined formulation containing these ingredients, preferably in a single lozenge.

It is therefore an object of the present invention to provide a nutritional, safe composition containing fish oil, garlic powder, rutin, capsaicin, vitamin A, vitamin C, vitamin E, selenium and juice concentrate for use as a dietary supplement in humans.

Another object is to provide novel compositions that increase HDL levels in human serum.

It is a further object of the present invention to provide a composition that reduces the level of O-LDL in human hemospermia.

It is another object of the present invention to provide compositions that reduce the levels of cholesterol and triglycerides in human serum.

It is another object of the present invention to provide a composition that can lower blood pressure in the human system.

Increasing HDL and lowering cholesterol, triglycerides, blood pressure and O-LDL will reduce the risk of heart disease in humans. Accordingly, it is a primary object of the present invention to reduce the risk of developing cardiovascular disease by providing for daily administration of the compositions of the present invention. Detailed Description

The present composition is intended for a daily dose to reduce the rate of heart attack and comprises (1) fish oil; (2) garlic powder; (3) rutin; (4) capsaicin; (5) a vitamin A; (6) vitamin C; (7) a vitamin E; (8) selenium; and (9) one or more juice concentrates.

In the description of the compositions of the present invention, the term "dose" means the daily dose-i.e. the total dose given in one day. A dose may thus comprise one or more dosage forms and such dosage forms may be administered one or more times on a single day.

The fish oil component of the compositions of the present invention may be obtained from commercial sources. [ Arista, Pharmachem ]. EPA and DHA are active components in fish oil. The fish oil component of the present invention comprises EPA in an amount of about 250mg to about 3500mg, and most preferably about 3000 mg. The remainder of the fish oil component contains 150mg to 2500mg DHA, and preferably 2000mg DHA. The total weight of the fish oil component of the present invention is about 500mg to 15,000mg, preferably 5000mg to 10,000mg per dose.

The garlic powder used in the composition of the present invention may be obtained from commercial sources. [ Extracts, Ashland, Pure-Gar ]. In addition, garlic powder in a deodorized and aged form is preferably used. The weight of garlic powder in a pharmaceutically acceptable form used in the composition of the present invention is about 100mg to 7,000mg, preferably 1,750mg to 6,500mg, most preferably about 3500mg of deodorized and aged garlic powder per dose.

Rutin for use in the compositions of the present invention may also be obtained from commercial sources. [ Westco Chemical, Freeman industries, Inc. ]. Each dose contains rutin 10-1500 mg, preferably 1000 mg.

The capsaicin used in the compositions of the present invention is also commercially available. [ AllChem, Good HopeBotanicals ]. Each dose of the composition of the present invention contains the capsaicin component in an amount of 20mg to 1500mg, preferably 1000 mg.

Multiple grades of vitamin A may be used as the vitamin A component of the present invention, with each dose containing about 1,000IU to 20,000IU, preferably 2,000IU to 15,000IU, and most preferably 2,500IU to 10,000IU of vitamin A component by weight.

Plural grades of vitamin C can be used as the vitamin C component of the present invention. Each dose contains about 50mg to 4,000mg, preferably 150mg to 3,000mg, and most preferably 175mg to 2,000mg of vitamin C component.

Multiple vitamin E levels can be used as vitamin E components in the present invention. Each dose contains about 50IU-1,000IU, preferably 75IU-925IU, and most preferably 125IU-425IU of vitamin E.

Multiple levels of organic selenium or selenium salts are also incorporated as the selenium component of the present invention. Alternatively, selenium yeast may be used as a source of selenium in the compositions of the invention. Selenium yeast in this form is available commercially. [ Universal FoodsCorp ]. Each dose contains the selenium component in an amount of about 20 μ g to about 400 μ g, preferably about 55 μ g to about 300 μ g, and most preferably about 150 μ g to about 250 μ g.

The total weight of juice concentrate contained in a preferred embodiment of the composition of the present invention is about 1,000mg to 7,500mg, and preferably 2,000mg to 6,000mg per dose.

The juice concentrate comprised in the composition of the invention has a concentration which is at least 10 times, preferably more than 15 times, most preferably more than 20 times that of the juice in its natural, unconcentrated form. The juice concentrate in concentrated form is completely anhydrous and is generally in powder form.

Acorn squash (acorn squash) concentrate forms suitable for use as a supplement to human diet in the present invention comprise from 1 to 20%, preferably from 7.5% to 15%, and most preferably from 8% to 12% by weight of the total juice concentrate ingredients of the present invention.

Alfalfa juice concentrates suitable for use as a dietary supplement in the present invention are present in an amount of from 1% to 20%, preferably from 7.5% to 15%, and most preferably from 8% to 12% by weight of the total juice concentrate component of the present invention.

The form of apple juice concentrate suitable for human dietary supplementation in the present invention comprises from 1% to 20%, preferably from 7.5% to 15%, and most preferably from 8% to 12% by weight of the total juice concentrate component of the present invention.

The plum juice concentrate suitable for dietary supplementation by the inventors is present in a form of 1% to 20%, preferably 7.5% to 15%, and most preferably 8% to 12% by weight of the total juice concentrate component of the present invention.

Artichoke juice concentrate, suitable for human dietary supplementation in the present invention, is present in a form of 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most suitably 2% by weight of the juice concentrate component of the present invention.

Avocado juice concentrate forms suitable for human dietary supplementation in the present invention comprise from 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most suitably 1% by weight of the juice concentrate component of the present invention.

The banana juice concentrate form suitable for human dietary supplementation in the present invention comprises from 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most suitably 1% by weight of the juice concentrate component of the present invention.

The sweet pepper juice concentrate suitable for human dietary supplementation in the present invention comprises from 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most preferably 1% by weight of the juice concentrate component of the present invention.

Broccoli juice concentrate suitable for human dietary supplementation in the present invention is present in a form of 1% to 20%, preferably 7.5% to 15%, and most preferably 8% to 12% by weight of the total juice concentrate component of the present invention.

The form of the Brussels sprouts concentrate, suitable for human dietary supplementation according to the present invention, represents 1% to 20%, preferably 7.5% to 15% by weight of the total juice concentrate component according to the present invention, and most preferably 8% to 12% by weight of the juice concentrate component according to the present invention.

The form of cabbage juice concentrate suitable for human dietary supplementation in the present invention comprises from 1% to 20% by weight of the total juice concentrate component of the present invention, and most preferably 2% by weight of the juice concentrate component of the present invention.

The muskmelon juice concentrate suitable for human dietary supplementation in the present invention is present in a form of 1% to 20%, preferably 7.5% to 15%, and most preferably 8% to 12% by weight of the total juice concentrate component of the present invention.

Carrot juice concentrates suitable for use as a dietary supplement in the present invention are present in an amount of from 1% to 20%, preferably from 7.5% to 15%, and most preferably from 8% to 12% by weight of the total juice concentrate component of the present invention.

The broccoli juice concentrate suitable for human dietary supplementation in the present invention is present in a form of 1% to 20%, preferably 7.5% to 15%, and most preferably 8% to 12% by weight of the total juice concentrate component of the present invention.

Celery juice concentrate forms suitable as a supplement to the human diet of the present invention comprise from 1% to 20%, preferably from 7.5% to 15%, and most preferably from 8% to 12% by weight of the total juice concentrate ingredients of the present invention.

The cherry juice concentrate suitable for human dietary supplementation in the present invention is present in a form of 1% to 20%, preferably 7.5% to 15%, and most preferably 8% to 12% by weight of the total juice concentrate component of the present invention.

The form of the kale greens juice concentrate suitable for human dietary supplementation in the present invention comprises 1% to 20% by weight of the total juice concentrate component of the present invention, and most preferably 2% by weight of the juice concentrate component of the present invention.

The grape juice concentrate forms suitable for human dietary supplementation in the present invention comprise from 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most preferably 2% by weight of the juice concentrate component of the present invention.

Grapefruit juice concentrates suitable for use as a dietary supplement in the present invention comprise from 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most preferably 2% by weight of the juice concentrate component of the present invention.

The green barley juice concentrate suitable for human dietary supplementation in the present invention is present in a form of 1% to 20%, preferably 7.5% to 15%, and most preferably 8% to 12% by weight of the total juice concentrate component of the present invention.

The leek juice concentrate suitable for human dietary supplementation in the present invention is present in a form of 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most preferably 2% by weight of the juice concentrate component of the present invention.

The green salad (green lette) juice concentrate suitable for use as a supplement to the human diet of the invention comprises from 0.5% to 20% by weight of the total juice concentrate component of the invention, and most preferably 1% by weight of the juice concentrate component of the invention.

The form of kale juice concentrate suitable for human dietary supplementation in the present invention represents between 0.5% and 20% by weight of the total juice concentrate component of the present invention, and most preferably 1% by weight of the juice concentrate component of the present invention.

The kiwi fruit juice concentrate forms suitable for human dietary supplementation herein comprise from 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most preferably 1% by weight of the juice concentrate component of the present invention.

The form of kale kohlrabi juice concentrate suitable for human dietary supplementation in the present invention represents between 0.5% and 20% by weight of the total juice concentrate component of the present invention, and most preferably 1% by weight of the juice concentrate component of the present invention.

The leek juice concentrate form suitable for human dietary supplementation in the present invention comprises 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most preferably 1% by weight of the juice concentrate component of the present invention.

Lettuce juice concentrate forms suitable for human dietary supplementation according to the present invention comprise from 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most preferably 1% by weight of the juice concentrate component of the present invention.

The onion juice concentrate forms suitable for human dietary supplementation herein comprise from 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most preferably 5% by weight of the juice concentrate component of the present invention.

The form of orange juice concentrate suitable for human dietary supplementation in the present invention comprises from 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most preferably 5% by weight of the juice concentrate component of the present invention.

The papaya juice concentrate suitable for human dietary supplementation in the present invention is present in a form of 1% to 20%, preferably 7.5% to 15%, and most preferably 8% to 12% by weight of the total juice concentrate component of the present invention.

The form of coriander juice concentrate suitable for human dietary supplementation herein comprises from 1% to 20%, preferably from 7.5% to 15%, and most preferably from 8% to 12% by weight of the total juice concentrate component of the present invention.

The potato juice concentrate forms suitable for human dietary supplementation herein comprise from 1% to 20%, preferably from 7.5% to 15%, and most preferably from 8% to 12% by weight of the total juice concentrate ingredients of the present invention.

The dried plum juice concentrate suitable for human dietary supplementation in the present invention is present in a form of 1% to 20%, preferably 7.5% to 15%, and most preferably 8% to 12% by weight of the total juice concentrate component of the present invention.

The kohlrabi juice concentrate suitable for human dietary supplementation in the present invention is present in a form of 1% to 20%, preferably 7.5% to 15%, and most preferably 8% to 12% by weight of the total juice concentrate component of the present invention.

Spinach juice concentrates suitable for human dietary supplementation in the present invention are present in a form of from 1% to 20%, preferably from 7.5% to 15%, and most preferably from 8% to 12% by weight of the total juice concentrate component of the present invention.

The form of strawberry juice concentrate suitable for human dietary supplementation in the present invention comprises from 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most preferably 2% by weight of the juice concentrate component of the present invention.

The sugarcane juice concentrate forms suitable for human dietary supplementation according to the present invention comprise from 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most preferably 2% by weight of the juice concentrate component of the present invention.

The form of sugar beet juice concentrate suitable for human dietary supplementation in the present invention comprises from 0.5% to 20% by weight of the total juice concentrate component of the present invention, and most preferably 2% by weight of the juice concentrate component of the present invention.

Tomato juice concentrates suitable for use as a supplement to the human diet of this invention comprise from 1% to 20% by weight of the total juice concentrate component of this invention, and most preferably 3% by weight of the juice concentrate component of this invention.

These preparations can be made by conventional methods and, in order to prepare the compositions of the invention, the fish oils mentioned above are used. The garlic powder, rutin and capsaicin components are combined into one preparation as the active ingredient and then mixed with a suitable carrier according to conventional mixing techniques. To prepare the compositions of the present invention, the vitamin A, vitamin E, vitamin C, selenium and juice concentrate ingredients described above are combined into one formulation as the active ingredient, which is then mixed with a suitable carrier according to conventional mixing techniques. The two formulations are then administered simultaneously.

Depending on the mode of administration of the formulation, such as: oral, sublingual, nasal or parenteral administration, optionally with a suitable carrier.

In preparing the compositions in oral dosage form, any of the usual pharmacological vehicles may be used. For oral liquid preparations (e.g., suspensions, elixirs and solutions), vehicles such as water, oils, alcohols, flavors, preservatives, colors, and the like may be employed. Carriers such as starches, sugars, diluents, granulating agents, lubricants, binders, disintegrating agents and the like may be used in the manufacture of oral solids (e.g., powders, gelatin capsules, pills and tablets). Gelatin capsules are the preferred oral dosage form. Elixirs and controlled release dosage forms may also be employed. Elixirs, tablets, pills and capsules are the best oral dosage unit form for their ease of administration, and in each case, solid pharmaceutical carriers are obviously employed. If desired, the tablets may be sugar coated or enteric coated using standard techniques.

Such additional inactive ingredients for convenient oral administration include (but are not limited to): lemon bioflavonoids (lemon bioflavonoids, fresh), caraway powder, bees , lecithin, gelatin, purified water and glycerol. These compounds can be used to make new nutritional supplement elixirs.

For parenteral products, the carrier will typically comprise sterile water, while other ingredients may also include, for example: to aid dissolution or for preservation purposes. Injectable suspensions may also be prepared, for example, using appropriate liquid carriers, suspending agents and the like.

The preferred method of using the invention is: the user ingests 5-10 lozenges of fish oil, garlic, rutin, and capsaicin preparations and 1-4 lozenges of vitamin a, vitamin E, vitamin C, selenium, and juice concentrates daily.

The following examples will illustrate preferred embodiments of the present invention. These examples are intended to be illustrative only, and are not intended to limit the invention in any way.

Example 1

The following examples provide a preferred composition of the invention. The compositions provided are two separate formulations: lozenge a (fish oil, garlic, rutin and capsaicin preparations), and lozenge B (vitamin a, vitamin E, vitamin C, selenium and juice concentrate preparations). Suitable daily dosages are 5-10 lozenges A and 1-4 lozenges B.

Lozenge A weight

Fish oil 570mg

Bulbus Allii powder 194mg

Rutin 11mg

Capsaicin 21mg

Lemon bioflavonoids 11mg

Herba Coriandri powder 38mg

d-alpha-tocopherol 5mg beeswax 75mg lecithin 75mg gelatin 255mg pure water 10mg glycerol 170mg^*The EPA and DHA in the fish oil are 300: 200. Lozenge B approximately contains 2,500IU vitamin C250 mg vitamin E50 IU selenium 50 μ g barley juice concentrate (approximately 20-1) 120mg spinach juice concentrate (approximately 20-1) 125mg alfalfa juice concentrate (approximately 20-1) 145mg caraway juice concentrate (approximately 20-1) 135mg artichoke juice concentrate (approximately 20-1) 135mg carrot juice concentrate (approximately 20-1) 130mg cabbage juice concentrate (approximately 20-1) 130mg strawberry juice concentrate (approximately 20-1) 130mg papaya juice concentrate (approximately 20-1) 130mg vitamin A (from β -carotene) 2,500IU vitamin C50 μ g vitamin A concentrate (approximately 20-1) 130mg vitamin A (from β -carotene) as component of example 2250mg vitamin E50 IU sodium selenate 50 μ g barley juice concentrate (about 20-1) 140mg spinach juice concentrate (about 20-1) 105mg alfalfa juice concentrate (about 20-1) 145mg caraway juice concentrate (about 20-1) 105mg artichoke juice concentrate (about 20-1) 115mg carrot juice concentrate (about 20-1) 145mg cabbage juice concentrate (about 20-1) 120mg strawberry juice concentrate (about 20-1) 140mg papaya juice concentrate (about 20-1) 130mg apple juice concentrate (about 20-1) 68mg fish oil 340mg glycerol 340mg^*980mg Garlic powder 350mg rutin 28mg capsaicin 22mg lemon bioflavonoid 12mg Caraway powder 31 mgd-alpha-Tocopherol 5mg^*The EPA and DHA in the fish oil are 300: 200. Example 3 the ingredients of example 3 were combined into two tablets. The daily dosage of these tablets is 5-10 doses per day. Component (A)About the content of fish oil^*340mg garlic powder 144mg rutin 13mg capsaicin 22mg lemon bioflavonoid 12mg caraway powder 31 mgd-alpha-tocopherol 5mg beeswax 75mg lecithin 75mg d-alpha-tocopheryl acetate 48mg700 IU/g [ Eastman chem. Co ].]Selenium Yeast (1,000ppm Se) 27mg [ Universal Foods Corp.]Beta-carotene (167,000IU/g) 29mg [ BASD Corp.]Riboflavin 0.9mg [ Takeda u.s.a., Inc.]Ascorbic acid (USP grade) 200mg [ Hoffmann-La roche, Inc.]Citrus pectin cellulose 6.3mg [ Stauber Performance Ingredients Inc ].]Microcrystalline cellulose 85mg [ FMC Corp.]Dicalcium phosphate 8.7mg [ Brown Chemical co.inc.]Magnesium stearate 1.5mg [ Stauber Performance Ingredients Inc ].]Freeze drying alfalfa powder 5.3mg[Freeze-dry products USA，Inc.]6.3mg of Freeze-dried apple powder [ Freeze-dry products USA, Inc.]Artichoke powder was Freeze-dried in an amount of 7.2mg [ Freeze-dry products USA, Inc.]Freeze-dried onion powder 7.9mg [ Freeze-dry products USA, Inc.]Freeze-dried banana powder 16mg [ Freeze-dry products USA, Inc.]Strawberry powder, 17mg, was Freeze-dried [ Freeze-dry products USA, Inc.]Freeze-dried Green mustard powder 12mg [ Freeze-dry products USA, Inc.]Freeze-dried papaya powder 13mg [ Freeze-dry products USA, Inc.]Freeze-dried green salad powder 19mg [ Freeze-dry products USA, Inc.]Tomato powder was Freeze-dried at 5mg [ Freeze-dry products USA, Inc.]The broccoli powder was Freeze-dried to 7.9mg [ Freeze-dry products USA, Inc.]The cabbage powder was Freeze-dried in an amount of 8.2mg [ Freeze-dry products USA, Inc.]Freeze-dried melon powder 10.1mg [ Freeze-dry products USA, Inc.]Freeze-dried cherry powder 7mg[Freeze-dry products USA，Inc.]The kale powder was Freeze-dried to 9mg [ Freeze-dry products USA, Inc.]Freeze-dried kiwifruit powder 8mg [ Freeze-dry products USA, Inc.]Freeze-dried broccoli powder 7mg [ Freeze-dry products USA, Inc.]6mg of grape powder was Freeze-dried [ Freeze-dry products USA, Inc.]Grapefruit powder 7mg [ Freeze-dry products USA, Inc.]Freeze-dried leek powder 8mg [ Freeze-dry products USA, Inc.]The powder of the sprouts of the Brussels sprouts was Freeze-dried to 7mg [ Freeze-dry products USA, Inc.]Orange powder was Freeze-dried to 6mg [ Freeze-dry products USA, Inc.]6mg of caraway powder was Freeze-dried [ Freeze-dry products USA, Inc.]The potato powder was Freeze-dried to 8mg [ Freeze-dry products USA, Inc.]Freeze-dried sweet Pepper powder 5mg [ Freeze-dry products USA, Inc.]Freeze-dried plum powder (5 mg) was obtained [ Freeze-dry products USA, Inc.]Freeze-dried carrot powder 12mg[Freeze-dry products USA，Inc.]Beet powder was Freeze-dried to 13mg [ Freeze-dry products USA, Inc.]Spinach powder was Freeze-dried to 5mg [ Freeze-dry products USA, Inc.]The almond powder was Freeze-dried to 13mg [ Freeze-dry products USA, Inc.]Freeze-dried avocado powder 5mg [ Freeze-dry products USA, Inc.]Freeze-drying of the acorn crushed powder 10mg [ Freeze-dry products USA, Inc.]11mg of powder of red cabbage was Freeze-dried [ Freeze-dry products USA, Inc.]Celery powder 12mg was Freeze-dried [ Freeze-dry products USA, Inc.]Freeze-dried broccoli powder 15mg [ Freeze-dry products USA, Inc.]The sweet potato powder was Freeze-dried to 14mg [ Freeze-dry products USA, Inc.]^*The EPA and DHA in the fish oil are 300: 200. Example 4 the ingredients of example 4 were combined into two lozenges comprising a daily dose of about 2-6 doses of the ingredients per day in an amount of fish oil^*580mg garlic powder 184mg rutin 13mg capsaicin 22mg lemon bioflavonoid 12mg coriander powderEnd 31mgd- α -Tocopherol 5mg beeswax 75mg lecithin 75mg d- α -Tocopherol acetate 250mg700 IU/g [ Eastman chem.]Selenium Yeast (1,000ppm Se) 130mg [ Universal Foods Corp.]Beta-carotene (167,000IU/g) 125mg [ BASD Corp.]Riboflavin 400mg [ Takeda u.s.a., Inc.]Ascorbic acid (USP grade) 600mg [ Hoffmann-La roche, Inc.]Citrus pectin cellulose 27mg [ Stauber Performance Ingredients Inc ].]Microcrystalline cellulose 190mg [ FMC Corp.]Dicalcium phosphate 82mg [ Brown Chemical co.inc.]Magnesium stearate 6.7mg [ Stauber Performance Ingredients Inc.]The alfalfa powder was lyophilized to 18mg [ Freeze-dry products USA, Inc.]Freeze-dried apple powder 17.2mg[Freeze-dry products USA，Inc.]Artichoke powder was Freeze-dried in 16.5mg [ Freeze-dry products USA, Inc.]Freeze-dried onion powder 19.6mg [ Freeze-dry products USA, Inc.]Freeze-dried banana powder 6.3mg [ Freeze-dry products USA, Inc.]Strawberry powder was Freeze-dried at 14.1mg [ Freeze-dry products USA, Inc.]Freeze-dried Green mustard powder 7mg [ Freeze-dry products USA, Inc.]Freeze-dried papaya powder 6mg [ Freeze-dry products USA, Inc.]Freeze-dried powder of green salad (6 mg) [ Freeze-dry products USA, Inc ].]Tomato powder was Freeze-dried at 6mg [ Freeze-dry products USA, Inc.]6mg of broccoli powder was Freeze-dried [ Freeze-dry products USA, Inc.]The cabbage powder was Freeze-dried to 7mg [ Freeze-dry products USA, Inc.]Freeze-dried melon powder 5mg [ Freeze-dry products USA, Inc.]Freeze-dried cherry powder 5mg [ Freeze-dry products USA, Inc.]Freeze-dried kale powder 10mg[Freeze-dry products USA，Inc.]Freeze-dried kiwifruit powder 8mg [ Freeze-dry products USA, Inc.]Freeze-dried broccoli powder 9mg [ Freeze-dry products USA, Inc.]Grape powder was Freeze-dried to 15mg [ Freeze-dry products USA, Inc.]Grapefruit powder 11mg was Freeze-dried [ Freeze-dry products USA, Inc.]Freeze-dried leek powder 11mg [ Freeze-dry products USA, Inc.]The bulb powder of the bulbous cabbage was Freeze-dried at 11mg [ Freeze-dry products USA, Inc.]Orange powder was Freeze-dried to 13mg [ Freeze-dry products USA, Inc.]Freeze-dried caraway powder 11mg [ Freeze-dry products USA, Inc.]Potato powder was Freeze-dried at 11mg [ Freeze-dry products USA, Inc.]Freeze-dried sweet Pepper powder 12mg [ Freeze-dry products USA, Inc.]Freeze-dried plum powder (6 mg) was obtained [ Freeze-dry products USA, Inc.]Carrot powder was Freeze-dried to 12mg [ Freeze-dry products USA, Inc.]Freeze-dried beet powder 6mg[Freeze-dry products USA，Inc.]Spinach powder was Freeze-dried to 18mg [ Freeze-dry products USA, Inc.]The almond powder was Freeze-dried to 19mg [ Freeze-dry products USA, Inc.]Freeze-dried avocado powder 15mg [ Freeze-dry products USA, Inc.]Freeze-dried acorn crushed powder 14mg [ Freeze-dry products USA, Inc.]The red cabbage powder was Freeze-dried in an amount of 8mg [ Freeze-dry products USA, Inc.]Celery powder was Freeze-dried to 5mg [ Freeze-dry products USA, Inc.]Freeze-dried broccoli powder 6mg [ Freeze-dry products USA, Inc.]The sweet potato powder was Freeze-dried to 7mg [ Freeze-dry products USA, Inc.]^*The EPA and DHA in the fish oil are 300: 200.

Many modifications may be made without departing from the spirit of the invention. It will therefore be apparent to those skilled in the art that within the scope of the appended claims, the invention may be practiced other than as specifically described. Therefore, it is intended that the following claims cover the invention encompassed by the claims and their substantial equivalents.

Claims (18)

1. A nutritional composition comprises fish oil, garlic powder, rutin, capsaicin, vitamin A, vitamin C, vitamin E, selenium, and one or more juice concentrates.

2. The nutritional composition of claim 1, wherein the juice concentrate is selected from the group consisting of: acorn crush concentrate, alfalfa juice concentrate, apple juice concentrate, plum juice concentrate, artichoke juice concentrate, avocado juice concentrate, banana juice concentrate, sweet pepper juice concentrate, broccoli juice concentrate, Brussels sprouts juice concentrate, cabbage juice concentrate, cantaloupe juice concentrate, carrot juice concentrate, cauliflower juice concentrate, celery juice concentrate, cherry juice concentrate, green mustard juice concentrate, grape juice concentrate, grapefruit juice concentrate, green barley juice concentrate, green leek juice concentrate, green salad juice concentrate, kale juice concentrate, kiwi juice concentrate, kohlrabi juice concentrate, leek juice concentrate, lettuce juice concentrate, onion juice, orange concentrate, papaya juice, coriander juice concentrate, potato juice concentrate, dried plum juice concentrate, kale juice concentrate, avocado juice concentrate, papaya juice, plum juice concentrate, potato juice concentrate, artichoke juice concentrate, or a combination thereof, Spinach juice concentrate, strawberry juice concentrate, sweet potato juice concentrate, beet juice concentrate, and tomato juice concentrate.

3. The nutritional composition of claim 1 wherein the fish oil component comprises from about 250mg to about 3500mg epa.

4. The nutritional composition of claim 1, wherein the fish oil component comprises about 150mg to about 2500mg dha.

5. The nutritional composition of claim 1, wherein the garlic powder comprises garlic powder in a deodorized and aged form.

6. The nutritional composition of claim 1, wherein the garlic powder comprises from about 100mg to about 7,000mg per dose.

7. The nutritional composition of claim 1, wherein rutin contains about 10mg-1500mg per dose.

8. The nutritional composition of claim 1, wherein the capsaicin is present in an amount from about 20mg to about 1500mg per dose.

9. The nutritional composition of claim 1, wherein the vitamin a component comprises about 1000IU-20000IU per dose.

10. The nutritional composition of claim 1, wherein the vitamin C component comprises about 50mg to about 4,000mg per dose.

11. The nutritional composition of claim 1, wherein the vitamin E component comprises from about 50IU to about 1000IU per dose.

12. The nutritional composition of claim 1, wherein the selenium component is selected from the group consisting of organic selenium, selenium salts, and selenium yeast.

13. The nutritional composition of claim 1, wherein the selenium component comprises 20 μ g to 400 μ g per dose.

14. The nutritional composition of claim 1, wherein the juice concentrate comprises a juice concentrate having a concentration at least 10 times greater than a natural unconcentrated form of the juice.

15. A method of supplementing the diet of a human comprising administering to the human a nutritional composition according to any one of claims 1-14.

16. A method of increasing the HDL level of human plasma comprising administering to a human the nutritional composition of any one of claims 1-14.

17. A method for reducing the O-LDL content of human plasma comprising administering to a human a nutritional composition according to any one of claims 1-14.

18. A method of reducing plasma cholesterol levels in a human comprising administering to the human a nutritional composition according to any one of claims 1-14.