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HK1018002A1 - 具有改进的生物利用度的抗真菌组合物 - Google Patents

具有改进的生物利用度的抗真菌组合物 Download PDF

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Publication number
HK1018002A1
HK1018002A1 HK99102947A HK99102947A HK1018002A1 HK 1018002 A1 HK1018002 A1 HK 1018002A1 HK 99102947 A HK99102947 A HK 99102947A HK 99102947 A HK99102947 A HK 99102947A HK 1018002 A1 HK1018002 A1 HK 1018002A1
Authority
HK
Hong Kong
Prior art keywords
dosage form
itraconazole
particles
mammal
weight
Prior art date
Application number
HK99102947A
Other languages
German (de)
English (en)
French (fr)
Other versions
HK1018002B (zh
Inventor
Elvire Colette Baert Lieven
Verreck Geert
Thone Dany
Original Assignee
詹森药业有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26142825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1018002(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 詹森药业有限公司 filed Critical 詹森药业有限公司
Publication of HK1018002A1 publication Critical patent/HK1018002A1/zh
Publication of HK1018002B publication Critical patent/HK1018002B/zh

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK99102947.2A 1996-05-20 1997-05-12 具有改进的生物利用度的抗真菌组合物 HK1018002B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP96201430 1996-05-20
EP96201430 1996-05-20
EP97200698 1997-03-07
EP97200698 1997-03-07
PCT/EP1997/002507 WO1997044014A1 (en) 1996-05-20 1997-05-12 Antifungal compositions with improved bioavailability

Publications (2)

Publication Number Publication Date
HK1018002A1 true HK1018002A1 (zh) 1999-12-10
HK1018002B HK1018002B (zh) 2004-04-16

Family

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Also Published As

Publication number Publication date
CZ188598A3 (cs) 1998-11-11
SK284145B6 (sk) 2004-10-05
CN1209740A (zh) 1999-03-03
JP3391801B2 (ja) 2003-03-31
AU722101B2 (en) 2000-07-20
BR9706897B1 (pt) 2010-09-21
AR007195A1 (es) 1999-10-13
IL124935A0 (en) 1999-01-26
DK0904060T3 (da) 2004-04-13
ATE255883T1 (de) 2003-12-15
BG102532A (en) 1999-02-26
US6509038B2 (en) 2003-01-21
EE03902B1 (et) 2002-12-16
AU2956297A (en) 1997-12-09
SI0904060T1 (en) 2004-04-30
PL330931A1 (en) 1999-06-07
EA199800571A1 (ru) 1998-12-24
US8591948B2 (en) 2013-11-26
HU227745B1 (en) 2012-02-28
KR19990044257A (ko) 1999-06-25
EE9800304A (et) 1999-02-15
CZ293841B6 (cs) 2004-08-18
TW460282B (en) 2001-10-21
US9642806B2 (en) 2017-05-09
EP0904060A1 (en) 1999-03-31
SK84898A3 (en) 1999-03-12
US20060263436A1 (en) 2006-11-23
WO1997044014A1 (en) 1997-11-27
NZ330739A (en) 1999-06-29
ID16926A (id) 1997-11-20
MX9805418A (es) 1998-10-31
HRP970270A2 (en) 1998-04-30
US7081255B2 (en) 2006-07-25
CA2240161C (en) 2005-05-24
HUP9901620A3 (en) 2000-03-28
DE69726729T2 (de) 2004-12-02
TR199801225T2 (xx) 1998-11-23
IL124935A (en) 2001-06-14
US20030082239A1 (en) 2003-05-01
CN1165291C (zh) 2004-09-08
BR9706897A (pt) 1999-08-31
EA001219B1 (ru) 2000-12-25
US20010007678A1 (en) 2001-07-12
ES2212810T3 (es) 2004-08-01
NO982599D0 (no) 1998-06-05
MY123827A (en) 2006-06-30
PL188566B1 (pl) 2005-02-28
PT904060E (pt) 2004-04-30
EP0904060B1 (en) 2003-12-10
JPH11509238A (ja) 1999-08-17
US20140134244A1 (en) 2014-05-15
CY2434B1 (en) 2004-11-12
HUP9901620A2 (hu) 1999-10-28
DE69726729D1 (de) 2004-01-22
CA2240161A1 (en) 1997-11-27
BG64368B1 (bg) 2004-12-30
HRP970270B1 (en) 2005-02-28
NO320495B1 (no) 2005-12-12
NO982599L (no) 1998-11-19

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PE Patent expired

Effective date: 20170511