[go: up one dir, main page]

HK1003115A1 - Il-1alpha derivatives and drugs - Google Patents

Il-1alpha derivatives and drugs Download PDF

Info

Publication number
HK1003115A1
HK1003115A1 HK98102171A HK98102171A HK1003115A1 HK 1003115 A1 HK1003115 A1 HK 1003115A1 HK 98102171 A HK98102171 A HK 98102171A HK 98102171 A HK98102171 A HK 98102171A HK 1003115 A1 HK1003115 A1 HK 1003115A1
Authority
HK
Hong Kong
Prior art keywords
polypeptide
cells
activity
amino acid
gene
Prior art date
Application number
HK98102171A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1003115B (en
Inventor
Nakai Satoru
Kaneta Mayumi
Haitsu-Datemusume Kikumoto Yoshikazu
Hong Yeong-Man
Haitsu Soreiyu Kawai Kazuyoshi
Takegata Setsuko
Ishii Kiyoshi
Yanagihara Yasuo
Hirai Yoshikatsu
Original Assignee
大�制药株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 大�制药株式会社 filed Critical 大�制药株式会社
Publication of HK1003115B publication Critical patent/HK1003115B/en
Publication of HK1003115A1 publication Critical patent/HK1003115A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L5/00—Devices for use where pipes, cables or protective tubing pass through walls or partitions
    • F16L5/02—Sealing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mechanical Engineering (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK98102171A 1986-03-14 1998-03-16 Il-1alpha derivatives and drugs HK1003115A1 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
JP5788586 1986-03-14
JP57885/86 1986-03-14
JP129759/86 1986-06-03
JP12975986 1986-06-03
JP14839386 1986-06-25
JP148393/86 1986-06-25
JP160250/86 1986-07-08
JP16025086 1986-07-08
JP200323/86 1986-08-27
JP20032386 1986-08-27

Publications (2)

Publication Number Publication Date
HK1003115B HK1003115B (en) 1998-10-09
HK1003115A1 true HK1003115A1 (en) 1998-10-09

Family

ID=27523408

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98102171A HK1003115A1 (en) 1986-03-14 1998-03-16 Il-1alpha derivatives and drugs

Country Status (8)

Country Link
US (5) US5008374A (da)
EP (2) EP0578278A1 (da)
JP (1) JP2572220B2 (da)
KR (1) KR950000886B1 (da)
DE (1) DE3750432T2 (da)
DK (2) DK171647B1 (da)
ES (1) ES2009216A6 (da)
HK (1) HK1003115A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5831022A (en) * 1986-02-18 1998-11-03 Hoffmann-La Roche Inc. Purification of recombinant human IL-1α
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
US5290917A (en) * 1988-02-03 1994-03-01 Dainippon Pharmaceutical Co., Ltd. Modified polypeptides of IL-1α
JP2698976B2 (ja) * 1988-02-03 1998-01-19 大日本製薬株式会社 新規ポリペプチド及びそれをコードするｄｎａ
US20030232010A2 (en) * 1988-03-29 2003-12-18 Immunomedics, Inc. Improved cytotoxic therapy
CA1329119C (en) * 1988-03-29 1994-05-03 Milton David Goldenberg Cytotoxic therapy
AU627480B2 (en) * 1988-07-29 1992-08-27 Otsuka Pharmaceutical Co., Ltd. Il-1alpha derivatives and medicament for treating thrombocytopenia
US5649904A (en) * 1988-10-07 1997-07-22 Sandoz Ltd. Method of treating cancer with a fully myeloablative regimen of chemotherapy, radiation or both
WO1990010068A1 (en) * 1989-02-27 1990-09-07 New England Medical Center Hospitals, Inc. Il-1 biological activity inhibitors
GB8915414D0 (en) * 1989-07-05 1989-08-23 Ciba Geigy Novel cytokines
AU642764B2 (en) * 1990-08-10 1993-10-28 Otsuka Pharmaceutical Co., Ltd. Agent for preventing and treating hepatitis
US5723117A (en) * 1990-08-10 1998-03-03 Otsuka Pharmaceutical Co., Ltd. Use of interleukin-1 (IL-1) to inhibit development of hepatitis
JP2818834B2 (ja) * 1991-08-12 1998-10-30 大塚製薬株式会社 ＩＬ−１α安定化医薬製剤
JPH06196070A (ja) * 1992-12-24 1994-07-15 Nec Corp 電磁継電器
US5866134A (en) * 1995-03-24 1999-02-02 Schering Corporation Method for enhancing the antibody response to specific antigens with Interleukin-10
US5753218A (en) * 1996-05-03 1998-05-19 Schering Corporation Method for treating inflammation
US7176179B1 (en) 1997-05-30 2007-02-13 The Regents Of The University Of California Selective induction of cell death by delivery of amino-terminal interleukin-1-α pro-piece polypeptide
US6191269B1 (en) 1997-05-30 2001-02-20 The Regents Of The University Of California Selective induction of cell death by delivery of amino-terminal interleukin-1-α pro-piece polypeptide
WO1999037321A1 (fr) * 1998-01-22 1999-07-29 Gosudarstvenny Nauchno-Issledovatelsky Institut Osobo Chistykh Biopreparatov (Gosnii Ochb) Preparation immuno-modulatrice a base d'interleukine 1 et procede de preparation
US20030154504A1 (en) * 1998-06-24 2003-08-14 Farese Robert V. Methods and compositions for modulating carbohydrate metabolism
US6270758B1 (en) 1998-10-08 2001-08-07 Duke University Substantially non-toxic biologically active mucosal adjuvants in vertebrate subjects
AU2002248192A1 (en) * 2000-12-15 2002-08-12 Stratagene Room temperature stable competent cells
US6855554B2 (en) * 2001-09-21 2005-02-15 Board Of Regents, The University Of Texas Systems Methods and compositions for detection of breast cancer
US20030211624A1 (en) * 2001-11-20 2003-11-13 Board Of Regents, The University Of Texas System Proteomic methods for diagnosis and monitoring of breast cancer
US20050154046A1 (en) * 2004-01-12 2005-07-14 Longgui Wang Methods of treating an inflammatory-related disease
US8563525B2 (en) 2004-01-12 2013-10-22 Natrogen Therapeutics International, Inc. Methods of treating an inflammatory-related disease
US7582670B2 (en) * 2001-12-13 2009-09-01 Natrogen Therapeutics, Inc. Methods of treating an inflammatory-related disease
CN101426268B (zh) * 2007-11-02 2010-08-25 大唐移动通信设备有限公司 导频资源分配方法、系统和设备

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568640A (en) * 1981-05-11 1986-02-04 Harvey Rubin Method of inserting amino acid analogs into proteins
FI82266C (fi) * 1982-10-19 1991-02-11 Cetus Corp Foerfarande foer framstaellning av il-2 -mutein.
US4512974A (en) * 1982-12-08 1985-04-23 Moldawer Lyle L Treatment of protein malnourished surgical patients
US4542017A (en) * 1982-12-09 1985-09-17 Moldawer Lyle L Treatment of protein malnourished bacterially infected humans with LEM
FR2550802B1 (fr) * 1983-08-17 1986-04-11 Inst Nat Sante Rech Med Procede de production d'interleukine 1 humaine et medicaments correspondants
JPS60149386A (ja) * 1984-01-17 1985-08-06 Dainippon Pharmaceut Co Ltd インタ−ロイキン１をコ−ドする伝令リボ核酸及びその調製法
CA1341401C (en) * 1984-03-23 2002-11-26 Adriano Fontana Immunosuppressant factor derived from human glioblastoma cells
EP0155433A1 (en) * 1984-03-23 1985-09-25 Adriano Fontana Immunosuppressant factor
DE3587669T2 (de) * 1984-05-18 1994-03-31 Massachusetts Inst Technology Menschliche IL-1-cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren.
US4762914A (en) * 1984-05-18 1988-08-09 Auron Philip E Truncated protein of interleukin-1
EP0569687B1 (en) * 1984-05-18 2002-08-21 New England Medical Center Hospitals, Inc. Human IL-1 cDNA sequences encoding biologically-active human IL-1 proteins
CA1341433C (en) * 1984-06-19 2003-06-24 Douglas P. Cerretti Purification of interleukin 1
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
EP0188920B1 (en) * 1984-12-25 1993-09-29 Dainippon Pharmaceutical Co., Ltd. Interleukin 1 and its derivative
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene
DE3683186D1 (de) * 1985-04-25 1992-02-13 Hoffmann La Roche Rekombinantes humaninterleukin-1.
IT1188550B (it) * 1986-02-07 1988-01-14 Sclavo Spa Peptide sintetico ad attivita' interleukina 1 umana
US4770781A (en) * 1986-03-03 1988-09-13 Merck & Co., Inc. Purification of human interleukin-1 species
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
US5017692A (en) * 1986-09-04 1991-05-21 Schering Corporation Truncated human interleukin-a alpha
US5047505A (en) * 1987-01-27 1991-09-10 Du Pont Merck Pharmaceutical Company High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
US5035887A (en) * 1989-09-07 1991-07-30 Institute Of Moelcular Biology, Inc. Wound healing composition of IL-1 and PDGF or IGF-1
US5211946A (en) * 1991-09-13 1993-05-18 Mycogen Corporation Bacillus thuringiensis isolates for controlling acarides

Also Published As

Publication number Publication date
ES2009216A6 (es) 1989-09-16
EP0237073B1 (en) 1994-08-31
KR950000886B1 (ko) 1995-02-03
US5371204A (en) 1994-12-06
DK127787A (da) 1987-09-15
US5702698A (en) 1997-12-30
DK171647B1 (da) 1997-03-03
KR870009023A (ko) 1987-10-22
JPS63164899A (ja) 1988-07-08
DE3750432T2 (de) 1995-04-20
US5008374A (en) 1991-04-16
DE3750432D1 (de) 1994-10-06
US5543140A (en) 1996-08-06
EP0578278A1 (en) 1994-01-12
DK172339B1 (da) 1998-04-06
EP0237073A2 (en) 1987-09-16
EP0237073A3 (en) 1989-11-15
US5342615A (en) 1994-08-30
JP2572220B2 (ja) 1997-01-16
DK127787D0 (da) 1987-03-12
DK51493D0 (da) 1993-05-05
DK51493A (da) 1993-05-05

Similar Documents

Publication Publication Date Title
EP0237073B1 (en) IL-1alpha derivatives and drugs
HK1003115B (en) Il-1alpha derivatives and drugs
US4959314A (en) Cysteine-depleted muteins of biologically active proteins
EP0261592B1 (en) Gene coding for human colony-stimulating factors
EP0237967B1 (en) IL-1 beta derivatives and drugs
US4898818A (en) Antitumor active substance, process for preparing the same, drug containing the substance, gene coding for the substance, vector containing the gene and recombinant microorganism
EP0098862A1 (en) Interferon-alpha 76
EP0098863A1 (en) Interferon-alpha 61
EP0099389A1 (en) Interferon-alpha 54
EP0328061A2 (en) Human colony-stimulating factors
EP0644203A1 (en) IL-1alpha derivatives and medicament for treating thrombocytopenia
US5847098A (en) DNA encoding interleukin IL-1β mutant
AU595864B2 (en) Il-1 alpha derivatives and drugs
US6107465A (en) IL-1β and derivatives thereof and drugs
EP0401379B1 (en) STABILIZED COMPOSITION OF INTERLEUKIN-1$g(b)
AU601173B2 (en) Il-beta derivatives and drugs
KR960010950B1 (ko) IL-1α 유도체 및 약제
JP2711430B2 (ja) インターロイキン−１α誘導体
JPH06219964A (ja) 抗腫瘍剤
JPH09118633A (ja) 医薬製剤
JP2753694B2 (ja) インターロイキン−１β誘導体及び医薬
JPH1072365A (ja) 医薬製剤
EP0495131B1 (en) Agent for preventing and treating hepatitis
JPH08245695A (ja) 抗腫瘍活性物質

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)