HK1003031B - 缩合嘧啶衍生物及其用作血管紧张素ⅱ拮抗物之用途 - Google Patents

缩合嘧啶衍生物及其用作血管紧张素ⅱ拮抗物之用途 Download PDF

Info

Publication number: HK1003031B
Authority: HK; Hong Kong
Prior art keywords: compound; formula; methyl; pyrimidin; pharmaceutically acceptable
Prior art date: 1991-10-24

Application number

HK98102075.7A

Other languages

German (de)

English (en)

French (fr)

Other versions

HK1003031A1 (zh

Inventor

Watson Ellingboe John

Nikaido Madelene

Franroz Bagli Jehan

Original Assignee

Wyeth

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-24

Filing date

1998-03-12

Publication date

1998-09-30

1991-10-24 Priority claimed from US07/782,025 external-priority patent/US5149699A/en

1992-04-07 Priority claimed from GB9207560A external-priority patent/GB2265899A/en

1992-06-25 Priority claimed from US07/901,485 external-priority patent/US5256654A/en

1998-03-12 Application filed by Wyeth filed Critical Wyeth

1998-09-30 Publication of HK1003031B publication Critical patent/HK1003031B/zh

1998-09-30 Publication of HK1003031A1 publication Critical patent/HK1003031A1/zh

Links

HK98102075A 1991-10-24 1998-03-12 縮合嘧啶衍生物及其用作血管緊張素ⅱ拮抗物之用途 HK1003031A1 (zh)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US782025		1991-10-24
US07/782,025 US5149699A (en)	1991-10-24	1991-10-24	Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560		1992-04-07
GB9207560A GB2265899A (en)	1992-04-07	1992-04-07	Substituted pyrimidines
US07/901,485 US5256654A (en)	1991-10-24	1992-06-25	Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
US901485		1992-06-25

Publications (2)

Publication Number	Publication Date
HK1003031B true HK1003031B (zh)	1998-09-30
HK1003031A1 HK1003031A1 (zh)	1998-09-30

Family

ID=27266132

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK98102075A HK1003031A1 (zh)	1991-10-24	1998-03-12	縮合嘧啶衍生物及其用作血管緊張素ⅱ拮抗物之用途

Country Status (21)

Country	Link
EP (1)	EP0539086B1 (zh)
JP (1)	JP3240192B2 (zh)
KR (1)	KR100286624B1 (zh)
CN (2)	CN1039324C (zh)
AT (1)	ATE161537T1 (zh)
AU (1)	AU653635B2 (zh)
CA (1)	CA2080705C (zh)
DE (1)	DE69223734T2 (zh)
DK (1)	DK0539086T3 (zh)
ES (1)	ES2111617T3 (zh)
FI (1)	FI103971B1 (zh)
GR (1)	GR3025926T3 (zh)
HK (1)	HK1003031A1 (zh)
HU (2)	HU218786B (zh)
IL (1)	IL103436A (zh)
LV (1)	LV12047B (zh)
NO (1)	NO301275B1 (zh)
SG (1)	SG47626A1 (zh)
SK (1)	SK322192A3 (zh)
TW (1)	TW226375B (zh)
UA (1)	UA27748C2 (zh)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0643704T3 (da) *	1991-11-18	2004-01-19	Merck & Co Inc	Tetrazolylphenylboronsyremellemprodukter til syntese af All-receptor antagonister
DK0618207T3 (da) *	1993-03-24	1999-08-30	American Home Prod	Substituerede pyridopyrimidiner som antihypertensiva
US5965738A (en) *	1994-09-20	1999-10-12	Wakunaga Seiyaku Kabushiki Kaisha	Process for producing N-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same
IT1292437B1 (it) *	1997-06-30	1999-02-08	Zambon Spa	Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US6638937B2 (en)	1998-07-06	2003-10-28	Bristol-Myers Squibb Co.	Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
PE20020617A1 (es)	2000-08-22	2002-08-05	Novartis Ag	Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina
US8168616B1 (en)	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0327839D0 (en)	2003-12-01	2003-12-31	Novartis Ag	Organic compounds
GB0402262D0 (en)	2004-02-02	2004-03-10	Novartis Ag	Process for the manufacture of organic compounds
JP2007529459A (ja)	2004-03-17	2007-10-25	ノバルティスアクチエンゲゼルシャフト	治療に置けるレニン阻害剤の使用
CN101102755B (zh)	2004-10-08	2013-01-02	诺瓦提斯公司	肾素抑制剂在制备预防或治疗舒张功能障碍或舒张性心力衰竭的药物中的用途
EP1749828A1 (en)	2005-08-04	2007-02-07	Farmaprojects S.L.	Process for preparing an angiotensin II receptor antagonist
JP5930573B2 (ja)	2007-03-01	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤の新規使用
EP2142514B1 (en)	2007-04-18	2014-12-24	Probiodrug AG	Thiourea derivatives as glutaminyl cyclase inhibitors
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2008261102B2 (en)	2007-06-04	2013-11-28	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2688079C (en) *	2007-06-07	2016-05-03	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	5beta, 14beta-androstane derivatives useful for the treatment of restenosis after angioplastic or endoartherectomy and diseases due to organ fibrosis
EP3239170B1 (en)	2008-06-04	2019-03-20	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en)	2008-07-16	2010-01-21	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
SG178953A1 (en)	2009-09-11	2012-04-27	Probiodrug Ag	Heterocylcic derivatives as inhibitors of glutaminyl cyclase
EP2542549B1 (en)	2010-03-03	2016-05-11	Probiodrug AG	Inhibitors of glutaminyl cyclase
WO2011110613A1 (en)	2010-03-10	2011-09-15	Probiodrug Ag	Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
US8541596B2 (en)	2010-04-21	2013-09-24	Probiodrug Ag	Inhibitors
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
US8530670B2 (en)	2011-03-16	2013-09-10	Probiodrug Ag	Inhibitors
BR112014014527A2 (pt)	2011-12-15	2017-06-13	Takeda Pharmaceuticals Usa Inc	combinações de azilsartan e clorotalidona para tratar hipertensão em pacientes negros
EP2970384A1 (en)	2013-03-15	2016-01-20	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
WO2014151200A2 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
HRP20240805T1 (hr)	2013-06-05	2024-09-27	Bausch Health Ireland Limited	Ultra-pročišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i uporabe
PL3461819T3 (pl)	2017-09-29	2020-11-30	Probiodrug Ag	Inhibitory cyklazy glutaminylowej

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0407342A3 (en) *	1989-07-06	1991-07-10	Ciba-Geigy Ag	Pyrimidine derivatives
US5100897A (en) *	1989-08-28	1992-03-31	Merck & Co., Inc.	Substituted pyrimidinones as angiotensin ii antagonists
EP0415886A3 (en) *	1989-08-30	1991-10-23	Ciba-Geigy Ag	Aza compounds
JPH05503530A (ja) *	1990-02-13	1993-06-10	メルク・エンド・カムパニー・インコーポレーテツド	置換ベンジル成分を含むアンギオテンシン２拮抗物質
IL100917A0 (en)	1991-02-16	1992-11-15	Fisons Plc	Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
US5149699A (en) *	1991-10-24	1992-09-22	American Home Products Corporation	Substituted pyridopyrimidines useful as antgiotensin II antagonists

1992
- 1992-08-27 TW TW081106755A patent/TW226375B/zh active
- 1992-09-30 FI FI924397A patent/FI103971B1/fi not_active IP Right Cessation
- 1992-10-01 AU AU26079/92A patent/AU653635B2/en not_active Ceased
- 1992-10-06 HU HU9203161A patent/HU218786B/hu not_active IP Right Cessation
- 1992-10-14 DK DK92309333.0T patent/DK0539086T3/da active
- 1992-10-14 AT AT92309333T patent/ATE161537T1/de not_active IP Right Cessation
- 1992-10-14 ES ES92309333T patent/ES2111617T3/es not_active Expired - Lifetime
- 1992-10-14 DE DE69223734T patent/DE69223734T2/de not_active Expired - Fee Related
- 1992-10-14 SG SG1996003253A patent/SG47626A1/en unknown
- 1992-10-14 EP EP92309333A patent/EP0539086B1/en not_active Expired - Lifetime
- 1992-10-15 IL IL10343692A patent/IL103436A/en not_active IP Right Cessation
- 1992-10-16 CA CA002080705A patent/CA2080705C/en not_active Expired - Fee Related
- 1992-10-23 NO NO924121A patent/NO301275B1/no not_active IP Right Cessation
- 1992-10-23 KR KR1019920019580A patent/KR100286624B1/ko not_active Expired - Fee Related
- 1992-10-23 JP JP28588592A patent/JP3240192B2/ja not_active Expired - Fee Related
- 1992-10-23 CN CN92113781A patent/CN1039324C/zh not_active Expired - Fee Related
- 1992-10-26 SK SK3221-92A patent/SK322192A3/sk unknown
1993
- 1993-06-18 UA UA93003129A patent/UA27748C2/uk unknown
1995
- 1995-06-29 HU HU95P/P00549P patent/HU211915A9/hu unknown
1997
- 1997-05-13 CN CN97111592A patent/CN1175414A/zh active Pending
1998
- 1998-01-15 GR GR980400096T patent/GR3025926T3/el unknown
- 1998-03-09 LV LVP-98-45A patent/LV12047B/en unknown
- 1998-03-12 HK HK98102075A patent/HK1003031A1/zh not_active IP Right Cessation

Publication	Publication Date	Title
EP0539086B1 (en)	1997-12-29	Condensed pyrimidine derivatives and their use as angiotensine II antagonists
US5149699A (en)	1992-09-22	Substituted pyridopyrimidines useful as antgiotensin II antagonists
HK1003031B (zh)	1998-09-30	缩合嘧啶衍生物及其用作血管紧张素ⅱ拮抗物之用途
US5225414A (en)	1993-07-06	Substituted azoles, a process for their preparation, and their use
EP0611368B1 (en)	1996-02-07	Substituted aminopyrimidines as angiotensin ii antagonists
JP3260415B2 (ja)	2002-02-25	アンギオテンシンｉｉ拮抗作用を有する複素環化合物
EP0445811B1 (en)	1995-06-14	Nitrogen-containing heterocyclic compounds, their production and use
US5466692A (en)	1995-11-14	Substituted pyridopyrimidines and antihypertensives
WO1993008170A1 (en)	1993-04-29	Substituted heterocycles as angiotensin ii antagonists
US5330989A (en)	1994-07-19	Heterocycles substituted with biphenyl-3-cyclobutene-1,2-dione derivatives
US5283242A (en)	1994-02-01	Substituted benzimidazoles and quinazolines as antihypertensives
US5256654A (en)	1993-10-26	Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
US4596799A (en)	1986-06-24	9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines
EP0618207B1 (en)	1999-01-07	Substituted pyridopyrimidines as antihypertensives
GB2265899A (en)	1993-10-13	Substituted pyrimidines
US6096754A (en)	2000-08-01	N-3 substituted pyrimidin-4-ones with AII antagonistic activity
HK1011358B (zh)	2000-04-28	取代吡啶并嘧啶用作抗高血压药物