HK1002279A - Heterocyclic compounds having tachykinin receptor antagonist activity, their preparation and their use - Google Patents

Description

Heterocyclic compounds having tachykinin receptor antagonistic activity, their preparation and use

Background

The present invention relates to a series of novel heterocyclic compounds having tachykinin receptor antagonistic activity. Also provided are methods and compositions for using them in the treatment and prevention of disease, as well as methods for preparing them and intermediates useful in their preparation.

The various forms of tachykinins present in mammals are associated with a variety of diseases and disorders, including respiratory diseases such as asthma, bronchitis, rhinitis and cough; (ii) an allergic reaction; ocular inflammations such as conjunctivitis and vernal conjunctivitis; skin diseases such as contact dermatitis, allergic dermatitis and urticaria; diseases related to rheumatism, such as rheumatoid arthritis; pain, such as migraine, headache and toothache; central nervous system disorders such as anxiety and alzheimer's disease; and gastrointestinal diseases such as colitis; and cystitis; and so on. Thus, inhibition of the activity of these forms of tachykinin would lead to novel treatments and/or prevention of these diseases and disorders.

The compounds of the invention are generally antagonistic to the tachykinin receptor but also to the substance P receptor (this receptor is generally referred to as the "neurokinin 1 receptor" -NK₁) And the neurokinin A receptor (this receptor is generally referred to as the "neurokinin 2 receptor" -NK₂) Has special antagonistic effect. The compounds of the invention are particularly advantageous in that they can simultaneously antagonize these receptors, also known as "dual action".

Compounds structurally related to the compounds of the present invention are disclosed in FR2729952, FR2729953 and FR 2729954. However, they are selectivelyActing on NK₁None of the compounds have the dual role of the compounds of the present invention.

Non-peptide compounds of low molecular weight are known to have antagonistic effects on these two receptors, for example, certain compounds disclosed in WO 9429309(1994), WO 9417045(1994), WO 9426735(1994) and WO 9528389 (1995). Typical examples of compounds disclosed in these documents include:compound AWO 9429309Compound BWO 9417045Compound CWO 9426735

However, these compounds are poorly absorbed orally. Thus, these prior art compounds cannot be administered orally and must be administered parenterally, e.g., by injection. As is common knowledge in the medical field, administration of any drug by injection is undesirable because it requires either training of the patient (and some patients are not trainable themselves) or administration by experienced medical personnel, which adds to the expense and inconvenience to both the patient and the medical personnel.

Therefore, there is a need to develop novel tachykinin receptor antagonists having the above dual effects, good oral absorption effect and low toxicity.

We have found a series of novel compounds which have antagonistic NK activity at least equivalent to those of the compounds of the prior art₁Are active and have a dual effect and they surprisingly have a tailored strong antagonistic NK₂The activity of the receptor.

Summary of The Invention

It is therefore an object of the present invention to provide a series of novel heterocyclic compounds.

It is another more specific object of the present invention to provide compounds having tachykinin receptor antagonistic activity.

It is another more specific object of the present invention to provide a toolSuch as NK₁And NK₂The tachykinin receptor antagonistic activity of a compound of (a).

It is another more specific object of the invention to provide compounds with greatly increased activity.

Other objects and advantages of the present invention will become apparent as the description proceeds.

The compounds of the present invention are compounds of formula (I) and its quaternary ammonium derivatives of formula (Ia), and their pharmaceutically acceptable salts and esters:wherein: r¹And R²Which may be the same or different, each represents a carbocyclic aryl or an aromatic heterocyclic group, the aryl and heterocyclic groups being unsubstituted or substituted by at least one substituent preferably selected from the group consisting of α, A represents a methylene group, a carbonyl group or a sulfonyl group, B represents the groups A and R¹An alkylene group having 1 to 4 carbon atoms or an alkenylene group having 2 to 4 carbon atoms; drepresents an oxygen or sulfur atom; e represents an alkylene group having 1 to 6 carbon atoms, a haloalkylene group having 1 to 6 carbon atoms, a cycloalkane-1, 1-diyl group having 3 to 6 carbon atoms, a cycloalkane-1, 1-diyl methyl group having 3 to 6 carbon atoms in the cycloalkane moiety or a cycloalkane-1, 1-di (ylmethyl) group having 3 to 6 carbon atoms in the cycloalkane moiety; g represents an alkylene group having 1 to 4 carbon atoms or an alkenylene group having 2 to 4 carbon atoms; l represents orGroup or formulaGroup wherein R³Denotes a carbocyclic aryl or aromatic heterocyclic radical, which aryl and aromatic heterocyclic radicals are unsubstituted or substituted by at least one substituent preferably selected from the group of substituents α⁴Represents a hydrogen atom, a carbocyclic aryl or aromatic heterocyclic group which is unsubstituted or substituted by at least one substituent preferably selected from the group consisting of α⁵Expression formula (I)A group, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an amino group, an amido group, a C1-C6 alkyl groupAn alkyl group substituted with an amido group, an amido group in which the nitrogen atom is substituted with an alkyl group having 1 to 6 carbon atoms, a hydroxyl group, a hydroxyalkyl group having 1 to 6 carbon atoms, an alkoxyalkyl group in which the alkoxy moiety and the alkyl moiety each have 1 to 6 carbon atoms, or an aralkyloxyalkyl group in which the oxyalkyl moiety has 1 to 6 carbon atoms, the alkyl moiety of the aralkyl moiety has 1 to 4 carbon atoms and is substituted with 1 to 3 carbocyclic aryl groups which are unsubstituted or substituted with at least one substituent α preferably custom defined wherein R is⁶Represents an alkyl group having 1 to 6carbon atoms, an alkoxy group having 1 to 6 carbon atoms, orA group, a carbocyclic aryl or heterocyclic group, the aryl and heterocyclic groups being unsubstituted or substituted by at least one substituent preferably selected from the group consisting of α

Wherein R is^aRepresents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, having 1 to 6 carbons

Alkoxy of an atom, aliphatic carboxylic acid acyl having 1 to 6 carbon atoms, having 1 to 6 carbons

Alkanesulfonyl of an atom, haloalkanesulfonyl having 1 to 6 carbon atoms, having 3 to 8

Cycloalkyl of carbon atoms, unsubstituted or substituted by at least one substituent preferably self-defined

α or wherein the alkyl moiety has from 1 to 4 carbon atoms and

aralkyl substituted by 1 to 3 carbocyclic aryl groups as defined above, and

wherein R is^bRepresents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, having 1 to 6 carbons

Alkoxy of an atom, aliphatic carboxylic acid acyl having 1 to 6 carbon atoms, having 1 to 6 carbons

Alkanesulfonyl of an atom, haloalkanesulfonyl having 1 to 6 carbon atoms, having 3 to 8

Cycloalkyl radicals, carbocyclic aryl radicals or aromatic heterocyclic radicals of carbon atoms, the aryl and aromatic heterocyclic radicals not being

Substituted or substituted by at least one substituent preferably selected from the group consisting of α

Wherein the alkyl moiety has from 1 to 4 carbon atoms and is taken up by from 1 to 3 carbocyclic aryl groups as defined above

A substituted aralkyl group,

or

R^aAnd R^bTogether with the nitrogen atom to which they are attached represent a nitrogen-containing heterocyclic group, R⁴And R⁵Together with the carbon atom to which they are attached represent a cycloalkyl group having 5 to 10 ring atoms, which is unsubstituted or substituted by at least one substituent selected from the group consisting of substituents β as defined below, and which has one heteroatom selected from nitrogen, oxygen and sulfur atoms, or R⁴And R⁵Together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclyl group as defined above and fused to a carbocyclic aryl or aromatic heterocyclyl group, which aryl and aromatic heterocyclyl group are unsubstituted or substituted by at least one substituent preferably defined as substituent α⁷Represents an alkyl group having 1 to 6 carbon atoms, and the above-mentioned substituent α is selected from the group consisting of a halogen atom, an alkyl group having 1 to 6 carbon atoms, a haloalkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an aliphatic carboxylic acid acyl group having 1 to 6 carbon atoms, an alkylsulfonyl group having 1 to 6 carbon atoms, an haloalkylsulfonyl group having 1 to 6 carbon atoms, a hydroxyl group, a carboxyl group, an alkoxycarbonyl group having 1 to 6 carbon atoms in the alkoxy moiety, an acylaliphatic carboxylic acid amino group having 1 to 6 carbon atoms, an alkylsulfonylamino group having 1 to 6 carbon atoms, an haloalkylsulfonyl group having 1 to 6 carbon atoms, an amino group, a cyano group, and an alkylene group having 1 to 8 carbon atoms (forming a cycloalkyl group fused with an aryl group or a heterocyclic group), the above-mentioned substituent β is:

when substituting carbon atoms, oxo

When substituted for a nitrogen atom, selected from alkylsulfonyl groups of 1 to 6 carbon atoms, having 1 to 6 carbon atoms

Alkyl which is unsubstituted or substituted by at least one substituent which is preferably defined by the following substituents γ,

aliphatic acyl radicals, unsubstituted or substituted by at least one substituent, preferably defined as substituent α above

Carbocyclic aryl radicals in which the alkyl part has from 1 to 4 carbon atoms and is interrupted by from 1 to 3 carbocyclic rings as defined above

An aryl-substituted aralkyl group, a substituted aralkyl group,

and when substituting the sulfur atom, one or two oxygen atoms to form a sulfoxide or sulfone group; and the above-mentioned substituent γ is selected from the group consisting of a halogen atom, an alkoxy group having 1 to 6 carbon atoms, an aliphatic carboxylic acid group having 1 to 6 carbon atoms, an alkylsulfonyl group having 1 to 6 carbon atoms, an haloalkylsulfonyl group having 1 to 6 carbon atoms, a hydroxyl group, a carboxyl group, an alkoxycarbonyl group having 1 to 6 carbon atoms in the alkoxy moiety, an aliphatic acylamino group having 1 to 6 carbon atoms, an amino group, and a cyano group.

The present invention also provides a composition for treating or preventing central nervous system disorders, neurodegenerative disorders, respiratory disorders, inflammatory disorders, allergy, allergic disorders, ophthalmic disorders, skin disorders, drug addiction, physical disorders caused by stress, sympathetically-reflective dystrophy, dysthymia, unwanted immune responses, disorders associated with increased immunity, digestive disorders, emesis, bladder disorders, eosinophilia, disorders caused by abnormal blood flow, and pain, comprising an effective amount of a compound of formula (I) or (Ia), or a pharmaceuticallyacceptable salt or ester thereof, in admixture with a pharmaceutically acceptable carrier or diluent.

The invention further provides a method of treatment or prophylaxis of diseases or disorders of the central nervous system, neurodegenerative diseases, respiratory diseases, inflammatory diseases, allergy, allergic diseases, ophthalmic diseases, dermatological diseases, drug addiction, physical disorders caused by stress, sympatholytic dystrophy, dysthymia, unwanted immune responses, diseases associated with increased immunity, diseases of the digestive system, emesis, bladder function disorders, eosinophilia, diseases caused by abnormal blood flow, and pain, which comprises administering to an animal, which may be a human, suffering from or susceptible to such a disease or disorder an effective amount of a compound of formula (I) or (Ia), or a pharmaceutically acceptable salt or ester thereof.

The present invention also provides compounds of formula (Iz):wherein:

j represents an alkylene group having 1 to 6 carbon atoms;

ar represents a fused ring of a carbocyclic aryl or aromatic heterocyclic group, the aryl and aromatic heterocyclic groups being unsubstituted or

Substituted with at least one substituent preferably customized to substituent α as above;

R¹⁴represents a hydrogen atom or an amino protecting group; and

represents a sulfoxide group in which the sulfur atom has the S-configuration.

Detailed description of the invention

When R is¹，R²，R³，R⁴，R⁶，R^a，R^bAr or the substituent β represents a carbocyclic aryl group having 5 to 14, preferably 6 to 14, more preferably 6 to 10, most preferably 6 or 10 ring carbon atoms, these groups may have a single aromatic ring or may have two or more fused aromatic rings, these groups may be unsubstituted or may be substituted with one or more substituents selected from the group consisting of the substituents α as defined above and listed below, except for the number of substitutable positions, sometimes sterically restricting the rings, the number of substituents is not limited, however, when the groups are substituted, we generally prefer 1 to 3 substituents.

Examples of substituted groups include 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 2, 4-dimethoxyphenyl, 2, 3-dimethoxyphenyl, 2, 5-dimethoxyphenyl, 3, 4-dimethoxyphenyl, 3, 5-dimethoxyphenyl, 2, 6-dimethoxyphenyl, 3, 4, 5-trimethoxyphenyl, 2, 3, 4-trimethoxyphenyl, 2, 3, 5-trimethoxyphenyl, 2, 3, 6-trimethoxyphenyl, 2, 4, 6-trimethoxyphenyl, 2-ethoxyphenyl, 3-ethoxyphenyl, 4-ethoxyphenyl, 2-isopropoxyphenyl, 3-isopropoxyphenyl, 4-isopropoxyphenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2, 4-dimethylphenyl, 2, 3-dimethylphenyl, 2, 5-dimethylpropyl, 3, 4-dimethylphenyl, 3, 5-dimethylphenyl, 2, 6-dimethylphenyl, 3, 4, 5-trimethylphenyl, 2, 3, 4-trimethylphenyl, 2, 3, 5-trimethylphenyl, 2, 3, 6-trimethylphenyl, 2, 4, 6-trimethylphenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 2, 4-dichlorophenyl, 2, 3-dichlorophenyl, 2, 5-dichlorophenyl, 3, 4-dichlorophenyl, 3, 5-dichlorophenyl, 2, 6-dichlorophenyl, 3, 4, 5-trichlorophenyl group, 2, 3, 4-trichlorophenyl group, 2, 3, 5-trichlorophenyl group, 2, 3, 6-trichlorophenyl group, 2, 4, 6-trichlorophenyl group, 2-fluorophenyl group, 3-fluorophenyl group, 4-fluorophenyl group, 2, 4-difluorophenyl group, 2, 3-difluorophenyl group, 3, 4-difluorophenyl group, 3, 5-difluorophenyl group, 2, 6-difluorophenyl group, 3, 4, 5-trifluorophenyl group, 2-trifluoromethylphenyl group, 3-trifluoromethylphenyl group, 4-trifluoromethylphenyl group, 2, 4-bis (trifluoromethyl) phenyl group, 2, 3-bis (trifluoromethyl) phenyl group, 3, 4-bis (trifluoromethyl) phenyl group, 3, 5-bis (trifluoromethyl) phenyl, 2, 6-bis (trifluoromethyl) phenyl, 3, 4, 5-tris (trifluoromethyl) phenyl, 2-acetamidophenyl, 3-acetamidophenyl, 4-acetamidophenyl, 2-methoxycarbonylphenyl, 3-methoxycarbonylphenyl, and 4-methoxycarbonylphenyl.

When substituent α is an alkylene group having 1 to 8 carbon atoms, it forms, together with the two carbon atoms of the aryl group to which it is attached, a cycloalkyl fused to the aryl group an example of a fused ring is 2, 3-indanyl.

When R is¹，R²，R³，R⁴，R⁶，R^bOr Ar represents an aromatic heterocyclic group, they have 5 to 7 ring atoms. A monocyclic ring in which 1 to 3 atoms are hetero atoms selected from nitrogen, oxygen and sulfur atoms, or in which at least one is as defined aboveThe other rings are fused ring systems of aromatic heterocyclic or carbocyclic aryl as defined above. When there are 3 heteroatoms in the heteroaromatic ring, they are preferably all nitrogen atoms, or have one or two nitrogen atoms, respectively two or one oxygen and/or sulfur atoms.

Examples of aryl heterocyclic groups include furyl, thienyl, pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1, 2, 3-oxadiazolyl, triazolyl, tetrazolyl, thiadiazolyl, pyranyl, pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl. Preferably a 5-to 7-membered aromatic heterocycle containing at least one nitrogen atom, optionally with additional nitrogen, oxygen or sulphur atoms, examples of such groups include pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1, 2, 3-oxadiazolyl, triazolyl, tetrazolyl, thiadiazolyl, pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl. Of these groups, pyridyl, imidazolyl, oxazolyl, pyrazinyl and thiazolyl are more preferable.

These heteroaryl groups may form fused rings with other cyclic groups, and examples of such fused ring systems include thienylyl, benzofuranyl, benzothienyl, benzoxazolyl, benzimidazolyl, isoquinolyl, quinolyl and quinoxalinyl.

These heteroaryl groups may be unsubstituted or substituted with one or more substituents selected from the group consisting of the substituents α defined above and exemplified below, the number of substituents being not particularly limited except for the limitation by steric hindrance at the substitution position.

Optionally, R⁶May represent non-aromatic (preferably saturated) heterocyclic groups which may have 5 to 7 ring atoms of which 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur atoms, preferably at least one of which is nitrogen. Examples of such groups include pyrrolidinyl, piperidinyl, piperazinyl, N-methylpiperazinyl, morpholinyl, thioxolinyl, oxazolidinyl, thiazolidinyl, diazolidinyl, oxolanyl, thiolanyl and perhydropyridinyl.

When B or G represents an alkylene group having 1 to 4 carbon atoms, they may be a linear or branched group having 1 to 4 carbon atoms, and examples thereof include methylene, methylmethylene, 1, 2-ethylene, 1, 2-propylene, 1, 3-propylene, 1, 4-butylene, 1-methyl-1, 3-propylene, 2-methyl-1, 3-propylene and 3-methyl-1, 3-propylene, among which a linear or branched alkylene group having 1 to 3 carbon atoms is preferred, a linear or branched alkylene group having 2 or 3 carbon atoms is more preferred, and a 1, 2-ethylene group or a 1, 3-propylene group is most preferred.

When B or G represents an alkenylene group having 2 to 4 carbon atoms, they may be a straight chain or branched group having 2 to 4 carbon atoms, and examples thereof include a vinylenegroup, a 2-propenylene group, a 1-methyl-2-propenylene group, a 2-ethyl-2-propenylene group and a 2-butenylene group, of which the vinylene group, the 2-propenylene group and the 3-butenylene group are preferred, and the vinylene group or the 2-propenylene group is more preferred.

When E or J represents an alkylene group having 1 to 6 carbon atoms, it may be a straight or branched chain group having 1 to 6 carbon atoms, examples thereof include methylene, methylmethylene, 1, 2-ethylene, 1, 2-propylene, 1, 3-propylene, 1, 4-butylene, 1-methyl-1, 3-propylene, 2-methyl-1, 3-propylene, 3-methyl-1, 3-propylene, 1, 5-pentylene, 1, 6-hexylene, 1, 1-dimethyl-1, 3-propylene, 2, 2-dimethyl-1, 3-propylene, 1, 1-dimethyl-1, 4-butylene, and 2, 2-dimethyl-1, 4-butylene. Among them, a linear or branched alkylene group having 1 to 4 carbon atoms is preferable, and a methylene group or a 1, 2-ethylene group is more preferable.

E may also represent a haloalkylene group having 1 to 6 carbon atoms substituted with 1 to 3 halogen atoms, preferably fluorine, chlorine, bromine and iodine atoms, wherein the alkylene group may be any of the unsubstituted alkylene groups exemplified above.

When E represents a cycloalkane-1, 1-diyl group having 3 to 6 carbon atoms, it is a group of the formulaWherein m is an integer from 2 to 5. When E represents a cycloalkane having a cycloalkyl moiety of 3 to 6 carbon atomsWhen the radical is a 1, 1-diyl methyl radical, it is a radical of the formulaWherein m is as defined above. When E represents cycloalkane-1, 1-bis (ylmethyl) group having 3 to 6 carbon atoms in the cycloalkyl moiety, it is a group of formulaWherein m is as defined above.

Examples of such groups include cyclopropane-1, 1-diyl, cyclobutane-1, 1-diyl, cyclopentane-1, 1-diyl, cyclohexane-1, 1-diyl, cyclopropane-1, 1-diyl methyl, cyclobutane-1, 1-diyl methyl, cyclopentane-1, 1-diyl methyl, cyclohexane-1, 1-diyl methyl, cyclopropane-1, 1-di (ylmethyl), cyclobutane-1, 1-di (ylmethyl), cyclopentane-1, 1-di (ylmethyl), cyclohexane-1, 1-di (ylmethyl), wherein cyclopropane-1, 1-diyl, cyclobutane-1, 1-diyl, cyclopropane-1, 1-diyl methyl and cyclobutane-1 are preferred, 1-diyl methyl group.

When R is⁵，R⁶，R⁷，R^a，R^bWhen the substituent α or the substituent β represents an alkyl group having 1 to 6 carbon atoms, it may be a straight-chain or branched-chain alkyl group having 1 to 6 carbon atoms, and examples thereof include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, 2-methylbutyl, neopentyl, 1-ethylpropyl, hexyl, isohexyl, 4-methylpentyl, 3-methylpentyl, 2-methylpentyl, 1-methylpentyl, 3, 3-dimethylbutyl, 2, 2-dimethylbutyl, 1, 1-dimethylbutyl, 1, 2-dimethylbutyl, 1, 3-dimethylbutyl, 2, 3-dimethylbutyl and 2-ethylbutyl groups, preferably straight-chain or branched-chain alkyl groups having 1 to 4 carbon atoms such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl and tert-butyl groups, of which methyl and ethyl groups are preferred.

When R is⁵，R⁶，R^a，R^bWhen the substituent γ or the substituent α represents an alkoxy group having 1 to 6 carbon atoms, it may be a straight-chain or branched alkoxy group having 1 to 6 carbon atoms, and examples thereof include methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxyA group selected from the group consisting of a sec-butoxy group, a tert-butoxy group, a pentyloxy group, an isopentyloxy group, a 2-methylbutyloxy group, a neopentyloxy group, a 1-ethylpropoxy group, a hexyloxy group, an isohexyloxy group, a 4-methylpentyloxy group, a 3-methylpentyloxy group, a 2-methylpentyloxy group, a 1-methylpentyloxy group, a3, 3-dimethylbutoxy group, a2, 2-dimethylbutoxy group, a 1, 1-dimethylbutoxy group, a 1, 2-dimethylbutoxy group, a 1, 3-dimethylbutoxy group, a2, 3-dimethylbutyl group, and a 2-ethylbutyl group, preferably a straight-chain or branched-chain alkoxy group having 1 to 4 carbon atoms, such as a methoxy group, an ethoxy group, a propoxy group, an isopropoxy group, a butoxy group.

When R is⁵When representing an acylamino group, the acyl moiety may be selected from a variety of acyl groups known in the art. For example, it may be: aliphatic acyl, such as alkanoyl, preferably having 1 to 21 carbon atoms, more preferably 1 to 6 carbon atoms, most preferably 2 to 6 carbon atoms, for example formyl, acetyl, propionyl, butyryl, isobutyryl, pivaloyl, valeryl, isovaleryl, octanoyl, nonanoyl, decanoyl, 3-methylnonanoyl, 8-methylnonanoyl, 3-ethyloctanoyl, 3, 7-dimethyloctanoyl, undecanoyl, dodecanoyl, tridecanoyl, tetradecanoyl, pentadecanoyl, hexadecanoyl, 1-methylpenecanoyl, 14-methylpenecanoyl, 13, 13-dimethyltetradecanoyl, heptadecanoyl, 15-methylhexadecanoyl, octadecanoyl, 1-methyldecadecanoylHeptaalkanoyl, nonadecanoyl, eicosanoyl or heneicosanoyl; haloalkanoyl, wherein the alkanoyl moiety may be any of the alkanoyl exemplified above except formyl, but is preferably alkanoyl having 2 to 6 carbon atoms, of which haloalkanoyl having 1 to 3 halogen atoms is preferred, such as chloroacetyl, dichloroacetyl, trichloroacetyl or trifluoroacetyl; an alkoxyalkyl group in which the alkoxy moiety has 1 to 6 carbon atoms and may be any of the alkoxy groups exemplified for R5 etc., as mentioned above, and the alkanoyl moiety may be any of the alkanoyl groups exemplified above except formyl, but preferably a group having 2 to 6 carbon atoms, for example, a methoxyacetyl group; alkenoylAn alkyl or alkanoyl group, preferably having 3 to 6 carbon atoms, e.g., acryloyl, propioloyl, methacryloyl, butyroyl, methacryloyl or (E) -2-methyl-2-butenoyl; aromatic acyl groups in which the aryl moiety may be R as defined above¹Aryl groups as defined and exemplified in (a) and (b) such as unsubstituted arylcarbonyl, e.g., benzoyl, 1-naphthoyl or 2-naphthoyl; haloarylcarbonyl groups in which the aryl moiety can be R as described above¹Aryl groups as defined and exemplified in (i) and (ii) such as 2-bromobenzoyl or 4-chlorobenzoyl; alkyl-substituted arylcarbonyl groups in which the aryl moiety can be R as described above¹Aryl as defined and exemplified in (1), and alkyl moieties can be R as described above⁵Alkyl as defined and exemplified in (1) and (b) such as 2, 4, 6-trimethylbenzoyl or 4-toluoyl; alkoxy-substituted arylcarbonyl groups in which the aryl moiety can be R as described above¹Aryl defined and exemplified in the above and alkoxy moieties can be R as described above⁵Alkoxy groups as defined and exemplified in (1) and (b) such as 4-methoxybenzoyl; nitro-substituted arylcarbonyl groups in which the aryl moiety may be R as described above¹Aryl groups as defined and exemplified in (1) and (2) such as 4-nitro-benzoyl or 2-nitrobenzoyl; alkoxycarbonyl-substituted arylcarbonyl groups in which the aryl moiety can be R as described above¹The alkoxy moiety of the arylalkoxycarbonyl group as defined and exemplified in (a) and (b) may be R as described above⁵Alkoxy as defined and exemplified in (1) and (b), such as 2- (methoxycarbonyl) benzoyl; aryl-substituted arylcarbonyl groups in which each aryl moiety can be R as described above¹Aryl groups as defined and exemplified in (1), (b), (c) and (d), etc., such as 4-phenylbenzoyl; alkoxycarbonyl having from 1 to 6, preferably from 1 to 4, carbon atoms in the alkoxy moiety (i.e.having from 2 to 7, preferably from 2 to 5, carbon atoms in total), such as methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, pentyloxycarbonyl, isopentyloxycarbonyl, 2-methylbutoxycarbonyl, neopentyloxycarbonyl, 1-ethylpropoxycarbonyl, hexyloxycarbonyl,iso-hexyloxycarbonyl, 4-methylpentyloxycarbonyl, 3-methylpentyloxycarbonyl, 2-methylpentyloxycarbonyl, 1-methylpentyloxycarbonyl, 3, 3-dimethylbutyloxycarbonyl, 2, 2-dimethylbutyloxycarbonyl, 11-dimethylbutoxycarbonyl, 1, 2-dimethylbutoxycarbonyl, 1, 3-dimethylbutoxycarbonyl, 2, 3-dimethylbutoxycarbonyl and 2-ethylbutyloxycarbonyl, preferably methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl and tert-butoxycarbonyl, with methoxycarbonyl, ethoxycarbonyl, tert-butoxycarbonyl and isobutoxycarbonyl being preferred; alkoxycarbonyl substituted by a halogen atom or trialkylsilyl group, wherein each alkyl moiety has 1 to 6 carbon atoms, such as 2, 2, 2-trichloroethoxycarbonyl or 2-trimethylsilylethoxycarbonyl; alkenylcarbonyl, the alkenyl moiety having from 2 to 6 carbon atoms, such as vinylcarbonyl and allylcarbonyl; aralkylcarbonyl in which the aromatic ring may be substituted by 1 or 2 alkoxy groups having 1 to 6 carbon atoms or by nitro groups, such as benzylcarbonyl, phenacylcarbonyl, 4-methoxybenzylcarbonyl, 3, 4-dimethoxybenzylcarbonyl, 2-nitrobenzylcarbonyl and 4-nitrobenzylcarbonyl; alkylsulfonyl groups having 1 to 6 carbon atoms such as methylsulfonyl group, ethylsulfonyl group and 1-propylsulfonyl group; fluoroalkanesulfonyl groups having 1 to 6 carbon atoms such as trifluoromethanesulfonyl and pentafluoroethanesulfonyl; arylsulfonyl wherein the aryl moiety is as above R¹Etc., such as phenylsulfonyl and p-toluenesulfonyl.

Among them, aliphatic acyl groups, aromatic acyl groups and alkylsulfonyl groups are preferred.

When R is⁵When an alkyl group having 1 to 6 carbon atoms is represented and substituted with an amido group, the alkyl moiety can be any of the above R⁵The alkyl, acyl substituents defined and exemplified in (A) can be any of the above R⁵Acyl groups as defined and exemplified in (1).

When R is⁵When representing an acylamino group in which a nitrogen atom is substituted with an alkyl group having 1 to 6 carbon atoms, the acyl substituent may be any of the above R⁵The acyl, alkyl moieties defined and exemplified in (A) can be any of the above R⁵Alkyl groups as defined and exemplified in (1).

When R is⁵When a hydroxyalkyl group having 1 to 6 carbon atoms is represented, it may be any of the above-mentioned alkyl groups substituted with at least one hydroxyl group,for example hydroxymethyl, hydroxyethyl, hydroxypropyl, hydroxybutyl, hydroxypentyl, or hydroxyhexyl.

When R is⁵When alkoxyalkyl is represented, the alkoxy and alkyl moieties can each be selected from the group consisting of R described above⁵The corresponding groups as defined and exemplified in (a). Examples of alkoxyalkyl groups include: methoxymethyl, ethoxymethyl, propoxymethyl, isopropoxymethyl, butoxymethyl, isobutoxymethyl, sec-butoxymethyl, tert-butoxymethyl, pentoxymethyl, isopentyloxymethyl, neopentyloxymethyl, hexyloxymethyl, isohexyloxymethyl, methoxyethyl, ethoxyethyl, propoxyethyl, isopropoxyethyl, butoxyethyl, isobutoxyethyl, sec-butoxyethyl, tert-butoxyethyl, pentyloxyethylOxyethyl, isopentyloxyethyl, neopentyloxyethyl, hexyloxyethyl, isohexyloxyethyl, methoxypropyl, ethoxypropyl, propoxypropyl, isopropyl, butoxypropyl, isobutoxypropyl, sec-butoxypropyl, tert-butoxypropyl, pentyloxypropyl, isopentyloxypropyl, neopentyloxypropyl, hexyloxypropyl, isohexyloxypropyl, methoxybutyl, ethoxybutyl, propoxybutyl, isopropoxybutyl, butoxybutyl, isobutoxybutyl, sec-butoxybutyl, tert-butoxybutyl, pentyloxybutyl, isopentoxybutyl, neopentyoxybutyl, hexyloxybutyl, isohexyloxybutyl, methoxypentyl, ethoxypentyl, propoxypentyl, isopropoxypentyl, butoxypentyl, isobutoxypentyl, sec-butoxypentyl, tert-butoxypentyl, pentyloxypentyl, isopentyloxypentyl, neopentyloxypentyl, hexyloxypentyl, isohexyl, methoxyhexyl, propoxyhexyl, isopropyloxyhexyl, butyloxyhexyl, isobutyloxyhexyl, sec-butyloxyhexyl, tert-butyloxyhexyl, pentyloxyhexyl, isopentyloxyhexyl, neopentyloxyhexyl, hexyloxyhexyl and isohexyloxyhexyl.

When R is⁵When representing aralkyloxyalkyl, the aralkyi moiety is an alkyl group having from 1 to 4 carbon atoms and substituted with from 1 to 3 carbocyclic aryl groups, the carbocyclic aryl groups being unsubstituted or substituted with at least one substituent preferably selected from the group defined above or exemplified below by α, and the alkyl group of the oxyalkyl moiety has from 1 to 6 carbon atoms the alkyl moiety can be any of the R's described above⁵The aralkyl moiety of (a) may be any of those defined and exemplified for substituent βSpecific examples of such a group include benzyloxymethyl, α -naphthylmethoxymethyl, β -naphthylmethoxymethyl, phenethoxymethyl, 2-benzyloxyethyl, 2- β -naphthylmethoxyethyl, 2- β -naphthylmethoxyethyl, 2-phenylethoxyethyl, 3-benzyloxypropyl, 3- β -naphthylmethoxypropyl, 3- β -naphthylmethoxypropyl, 3-phenylethoxypropyl, 4-benzyloxybutyl, 4- α -naphthylmethoxybutyl, 4- β -naphthylmethoxybutyl, 4-phenylethoxybutyl, 5-benzyloxypentyl, 5- α -naphthylmethoxypentyl, 5- β -naphthylmethoxypentyl, 5-phenylethoxypentyl, 6-benzyloxyhexyl, 6- α -naphthylmethoxyhexyl, 6- β -naphthylmethoxyhexyl and 6-phenylethoxyhexyl.

When R is^aAnd R^bWhen the substituent α or the substituent gamma represents an aliphatic carboxylic acid group, it may be R as described above⁵Any of the aliphatic acyl groups, haloalkanoyl groups, alkoxyalkanoyl groups, alkenoyl groups, acyl groups, alkoxycarbonyl groups substituted with a halogen atom, and alkenylcarbonyl groups, particularly formyl group, acetyl group, propionyl group, butyryl group, isobutyryl group, Valeryl group (Pentanoyl group), pivaloyl group, Valeryl group (Valeryl group) and isovaleryl group, preferably acetyl group and propionyl group, defined and exemplified in (a).

When R is^aAnd R^bWhen the substituent α or the substituent γ represents an alkylsulfonyl group or a haloalkylsulfonyl group, it may be any of the above-mentioned R⁵And those defined and exemplified for substituent β.

When R is^aAnd R^bWhen a cycloalkyl group is represented, it may have 3 to 8 ring carbon atoms, and examples thereof include ringsPropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl, with cyclopentyl and cyclohexyl being preferred.

When R is^aAnd R^bWhen it represents a nitrogen-containing heterocyclic group together with the nitrogen atom to which they are attached, it may have 5 to 7 ring atoms of which 1 to 3 hetero atoms selected from nitrogen, oxygen and sulfur atoms, at least one of which is nitrogen. The heterocyclic group is preferably a saturated (non-aromatic) group. Examples include pyrrolidinyl, piperidinyl, piperazinyl, N-methylpiperazinyl, morpholinyl and thioxolinyl.

When R is⁴And R⁵When taken together with the carbon atom to which they are attached represent a cycloalkyl group having 5 to 10 ring atoms or a heterocyclyl group, which group is unsubstituted or substituted with at least one substituent selected from the group consisting of substituents β as defined above⁴And R⁵Together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclyl group as defined above fused to a carbocyclic aryl or aromatic heterocyclyl group, the aryl and aromatic heterocyclyl groups being unsubstituted or substituted by at least one substituent preferably defined as substituent α above^aAnd R^bAnd R¹And R⁶Etc. and the above R^aAnd R^bThe cycloalkyl groups exemplified in (1).

From R⁴And R⁵One particularly preferred group represented together is a group of the formula:wherein Ar, J andas defined above.

When the substituent α or the substituent γ represents a halogen atom, it may be fluorine, chlorine, bromine or iodine, preferably a fluorine or chlorine atom.

When the substituent α represents a haloalkyl group, the alkyl moiety may be a straight-chain or branched-chain alkyl group having 1 to 6, preferably 1 to 3 carbon atoms, the number of halogen atoms is not limited except for the limitation of the number of substitution positions, and 1 to 3 halogen atoms are generally preferred examples of the group include trifluoromethyl, trichloromethyl, difluoromethyl, dichloromethyl, dibromomethyl, fluoromethyl, chloromethyl, bromomethyl, iodomethyl, 2, 2, 2-trichloroethyl, 2, 2, 2-trifluoroethyl, 2-bromoethyl, 2-chloroethyl, 2-fluoroethyl, 2-iodoethyl, 2, 2-dibromoethyl, 3-bromopropyl, 3-chloropropyl, 3-fluoropropyl, 3-iodopropyl, 4-bromobutyl, 4-chlorobutyl, 4-fluorobutyl, 4-iodobutyl, 5-bromopentyl, 5-chloropentyl, 5-fluoropentyl, 5-iodopentyl, 6-bromohexyl, 6-chlorohexyl, 6-fluorohexyl and 6-iodohexyl, wherein trifluoromethyl, 2-bromoethyl and 2-chloroethyl are preferred.

When the substituent α or the substituent γ represents an alkoxycarbonyl group having 1 to 6 carbon atoms in the alkoxy moiety, it may be R as described above⁵Any such groups as defined and exemplified in (a).

When the substituent α or the substituent γ represents an amido group, the acyl moiety may be R as described above⁵Etc. of any such groups exemplified therein. Particularly preferred examples of such groups include aliphatic carboxamido groups such as carboxamido, acetylamino, propionylamino, butyrylamino, isobutyrylamino, pentanoylamino (pentanoylamino), pivaloylamino, pentanoylamino (valrylamino) and isovalerylamino, preferably acetylamino and propionylamino.

When substituent β represents an alkylsulfonyl group having 1 to 6 carbon atoms, it may be a straight-chain or branched-chain group having 1 to 6, preferably 1 to 4 carbon atoms, and examples include a methylsulfonyl group, an ethylsulfonyl group, a propylsulfonyl group, an isopropylsulfonyl group, a butylsulfonyl group, an isobutylsulfonyl group, a sec-butylsulfonyl group, a tert-butylsulfonyl group, a pentylsulfonyl group, an isopentylsulfonyl group, a neopentylsulfonyl group, a 2-methylbutylsulfonyl group, a 1-ethylpropylsulfonyl group, a 4-methylpentylsulfonyl group, a 3-methylpentylsulfonyl group, a 2-methylpentylsulfonyl group, a 1-methylpentylsulfonyl group, a3, 3-dimethylbutylsulfonyl group, a2, 2-dimethylbutylsulfonyl group, a 1, 1-dimethylbutylsulfonyl group, a 1, 2-dimethylbutylsulfonyl group, a 1, 3-dimethylbutylsulfonyl group, a 2-ethylbutylsulfonyl group, a hexylsulfonyl group and an isohexylsulfonyl group.

When R is^aAnd R^bOr the substituent β represents an aralkyl group in which the alkyl group has 1 to 4 carbon atoms and is substituted by 1 to 3 carbocyclic aromatic groups as defined above, and examples thereof include benzyl group, α -naphthylmethyl group, α 0-naphthylmethyl group, indenylmethyl group, phenanthryl group, anthracenylmethyl group, benzhydryl group, trityl group, 1-phenylethyl group, 2-phenylethyl group, 1- α -naphthylethyl group, 2- α -naphthylethyl group, 1- β -naphthylethyl group, 2- β -naphthylethyl group,1-phenylpropyl group, 2-phenylpropyl group, 3-phenylpropyl group, 1- α -naphthylpropyl group, 2- α -naphthylpropyl group, 3- α -naphthylpropyl group, 1- β -naphthylpropyl group2- β -naphthylpropyl, 3- β -naphthylpropyl, 1-phenylbutyl, 2-phenylbutyl, 3-phenylbutyl, 4-phenylbutyl, 1- β 0-naphthylbutyl, 2- β 1-naphthylbutyl, 3- α -naphthylbutyl, 4- α -naphthylbutyl, 1- β -naphthylbutyl, 2- β -naphthylbutyl, 3- β -naphthylbutyl, 4- β -naphthylbutyl, 1-phenylpentyl, 2-phenylpentyl, 3-phenylpentyl, 4-phenylpentyl, 5-phenylpentyl, 1- α -naphthylpentyl, 2- α -naphthylpentyl, 3-α -naphthylpentyl group, 4- α -naphthylpentyl group, 5- α 0-naphthylpentyl group, 1- α 4-naphthylpentyl group, 2- α 5-naphthylpentyl group, 3- α 7-naphthylpentyl group, 4- α 8-naphthylpentyl group, 5- α 9-naphthylpentyl group, 1-phenylhexyl group, 2-phenylhexyl group, 3-phenylhexyl group, 4-phenylhexyl group, 5-phenylhexyl group, 6-phenylhexyl group, 1- α 1-naphthylhexyl group, 2- α 2-naphthylhexyl group, 3- α 3-naphthylhexyl group, 4- α -naphthylhexyl group, 5- α -naphthylhexyl group, 6- α -naphthylhexyl group, 1- β -naphthylhexyl group, 2- β -naphthylhexyl group, 3- α 6-naphthylhexyl group, 4- β -naphthylhexyl group, 5- β -naphthylhexyl group and 6- β -naphthylhexyl group, wherein we prefer an aralkyl group in which the base is benzene and the alkyl group has 1 to 4 carbon atoms, more preferably benzyl group or benzene ethyl group.

When R is^14＇When an amino protecting group is represented, it is represented by the above-mentioned R⁵Any of the aliphatic ester groups, aromatic acyl groups and alkoxycarbonyl groups defined and exemplified in the above, or alkenyloxycarbonyl groups, aralkyloxycarbonyl groups and silyl groups defined and exemplified in the following ester groups. Among them, t-butoxycarbonyl is preferred.

Each compound of the present invention contains a base in its molecule, and thuscan form an acid addition salt. Examples of acid addition salts include: salts with inorganic acids, in particular hydrohalic acids (such as hydrofluoric, hydrobromic, hydroiodidic or hydrochloric acid), nitric acid, perchloric acid, carbonic acid, sulfuric acid or phosphoric acid; salts with lower alkylsulfonic acids, such as methanesulfonic acid, trifluoromethanesulfonic acid and ethanesulfonic acid, salts with arylsulfonic acid, benzenesulfonic acid or p-toluenesulfonic acid; salts with organic carboxylic acids, such as acetic acid, fumaric acid, tartaric acid, oxalic acid, maleic acid, malic acid, succinic acid, benzoic acid, mandelic acid, ascorbic acid, lactic acid, gluconic acid or citric acid; and salts with amino acids such as glycine, arginine, ornithine, lysine, glutamic acid or aspartic acid.

Since the compounds of the formula (I) according to the invention can be prepared by reacting R with⁷Radical modified piperazineThe nitrogen atom of the pyridino or piperazinyl group is converted to a quaternary ammonium and the invention therefore also includes salts of compounds of formula (I) having a cation or anion which may be any atomic group capable of forming an anion, for example a halogen atom such as chloride, and iodide.

The compounds of formula (I) according to the invention may sometimes be converted into hydrates by already absorbed water or by adhering absorbed water when placed in the atmosphere, and the invention also includes such hydrates.

As part of the present invention, the compounds of formula (I) of the present invention may form esters. When the compound is used for therapeutic purposes, its ester may be a pharmaceutically acceptable ester, and obviously, it should not be more toxic (or have unacceptably higher toxicity) than the parent compound, and it should not be less active (or have unacceptably lower activity) than the parent compound. The esters may be either "normal"or "biodissociable" esters, both of which may be used as protecting groups.

"typical" esters are esters that can be cleaved by chemical means such as hydrogenolysis, hydrolysis, electrolysis, photolysis, and the like. Examples of groups that can form esters with hydroxyl groups include:

the above-mentioned aliphatic acyl group;the above aromatic acyl group; tetrahydropyranyl or tetrahydrothiopyranyl groups such as tetrahydropyran-2-yl, 3-bromotetrahydropyran-2-yl, 4-methoxytetrahydropyran-4-yl, tetrahydrothiopyran-2-yl and 4-methoxytetrahydrothiopyran-4-yl; tetrahydrofuranyl or tetrahydrothienyl, such as tetrahydrofuran-2-yl or tetrahydrothiophen-2-yl; silyl groups, trialkylsilyl groups having 1 to 6 carbon atoms in each alkyl group (e.g. trimethylsilyl, triethylsilyl, isopropyldimethylsilyl, tert-butyldimethylsilyl, methyldiisopropylsilyl, methyl di-tert-butylsilyl and triisopropylsilyl), in which one or two alkyl groups are substituted by the above-mentioned R¹The aryl-substituted trialkylsilyl groups defined and exemplified above having 1 to 6 carbon atoms in each alkyl group (e.g., diphenylmethylsilyl, diphenylbutylsilyl, diphenylisopropylsilyl and phenylisopropylsilyl); optionally substituted alkanes having 1 to 6 carbon atoms in the alkoxy moietyOxymethyl groups, such as alkoxymethyl (e.g., methoxymethyl, 1, 1-dimethyl-1-methoxymethyl, ethoxymethyl, propoxymethyl, isopropoxymethyl, butoxymethyl and tert-butoxymethyl, alkoxyalkoxymethyl groups having 1 to 6 carbon atoms in each alkoxy moiety (e.g., 2-methoxyethoxymethyl), haloalkoxymethyl groups having 1 to 6 carbon atoms in the alkoxy moiety [ e.g., 2, 2, 2-trichloroethoxymethyl and bis (2-chloroethoxy) methyl]Substituted ethyl groups such as alkoxyethyl groups having 1 to 6 carbon atoms in the alkoxy moiety (e.g. 1-ethoxyethyl and 1-isopropoxyethyl), haloethyl groups (e.g. 2, 2, 2-trichloroethyl), aralkyl groups as defined above for substituent β, preferably alkyl groups substituted with 1 to 3 aryl groups (e.g. benzyl, α -naphthylmethyl, β -naphthylmethyl, benzhydryl, trityl, α -naphthyldiphenylmethyl and 9-naphthylmethyl), lower alkyl groups substituted with 1 to 3 aryl groups, wherein the aryl groups are substituted with lower alkyl groups, lower alkoxy groups, nitro, halogen or cyano groups, (e.g. 4-methylbenzyl, 2, 4, 6-trimethylbenzyl, 3, 4, 5-trimethylbenzyl, 4-methoxybenzyl, 4-methoxyphenyldiphenylmethyl, 2-nitrobenzyl, 4-chlorobenzyl, 4-bromobenzyl and 4-cyanobenzyl), alkoxycarbonyl groups such as vinyloxycarbonyl and allyloxycarbonyl groups, aralkyloxycarbonyl groups which may be substituted with 1 or 2 lower alkoxy groups or nitro groups such as benzyloxycarbonyl, 4-nitrobenzyl and 4-cyanobenzyl and 2-nitrobenzyl groups.

The biologically cleavable esters contain groups which can be cleaved by biological means, such as biodegradation, to form the free acid or salt thereof. Whether an ester is biodegraded can be determined by injecting the ester intravenously into a test animal (e.g., a rat or mouse), examining the body fluids of the animal after administration and testing the original, compound or pharmaceutically acceptable salt thereof.

Examples of biodissociable esters include:

1- (acyloxy) lower alkyl, e.g. 1- (aliphatic acyloxy) lower alkyl (e.g. formyloxy)

Methyl, acetoxymethyl, dimethylaminoacetoxymethyl, propionyloxymethyl, butyryloxymethyl, nov

Valeryloxymethyl, isovaleryloxymethyl, hexanoyloxymethyl, 1-formyloxyethyl,

1-acetoxyethyl group, 1-propionyloxyethyl group, 1-butyryloxyethyl group, 1-pivaloyloxyethyl group,

1-valeryloxyethyl group, 1-isovaleryloxyethyl group, 1-hexanoyloxyethyl group, 1-formyloxypropyl group,

1-acetoxypropyl group, 1-propionyloxypropyl group, 1-butyryloxypropyl group, 1-pivaloyloxypropyl group,

1-valeryloxypropyl group, 1-isovaleryloxypropyl group, 1-hexanoyloxypropyl group, 1-acetoxybutyl group,

1-propionyloxybutyl, 1-butyryloxybutyl, 1-pivaloyloxybutyl, 1-acetoxypentyl,

1-propionyloxypentyl, 1-butyryloxypentyl, 1-pivaloyloxypentyl and 1-pivaloyloxyhexyl

Radical);

1- (Cycloalkylcarbonyloxy) lower alkyl (e.g. cyclopentylcarbonyloxymethyl, cyclohexylcarbonyloxymethyl)

1-cyclopentylcarbonyloxyethyl group, 1-cyclohexylcarbonyloxyethyl group, 1-cyclopentylcarbonyloxypropyl group,

1-cyclohexylcarbonyloxypropyl, 1-cyclopentylcarbonyloxybutyl and 1-cyclohexylcarbonyloxybutyl);

1- (aroyloxy) lower alkyl (e.g., benzoyloxymethyl);

carbonyloxyalkyl radicals, e.g. (alkoxycarbonyloxy) alkyl and (cycloalkyloxycarbonyloxy) alkyl (e.g. methoxy)

Carbonyloxymethyl, ethoxycarbonyloxymethyl, propoxycarbonyloxymethyl, isopropoxycarbonyloxymethyl, butanes

Oxycarbonyloxymethyl, isobutoxycarbonyloxymethyl, pentyloxycarbonyloxymethyl, hexyloxycarbonyloxymethyl,

cyclohexyloxycarbonyloxymethyl, cyclohexyloxycarbonyloxy (cyclohexyl) methyl, 1- (methoxycarbonyl)

Oxy) ethyl, 1- (ethoxycarbonyloxy) ethyl, 1- (propoxycarbonyloxy) ethyl, 1

- (isopropyloxycarbonyloxy) ethyl, 1- (butyloxycarbonyloxy) ethyl, 1- (isobutyloxycarbonyloxy)

Ethyl, 1- (tert-butoxycarbonyloxy) ethyl, 1- (pentyloxycarbonyloxy) ethyl, 1- (hexyloxy)

Oxycarbonyloxy) ethyl group, 1- (cyclopentoxycarbonyloxy) propyl group,

1- (cyclohexyloxycarbonyloxy) propyl, 1- (cyclopentyloxycarbonyloxy) butyl, 1- (cyclohexyloxy)

Carbonyl oxygen) butyl, 1- (cyclohexyloxycarbonyloxy) ethyl, 1- (ethoxycarbonyloxy) propyl,

2- (methoxycarbonyloxy) ethyl, 2- (ethoxycarbonyloxy) ethyl, 2- (propoxycarbonyloxy)

Ethyl, 2- (isopropyloxycarbonyloxy) ethyl, 2- (butyloxycarbonyloxy) ethyl, 2- (iso

Butoxycarbonyloxy) ethyl, 2- (pentyloxycarbonyloxy) ethyl 2- (hexyloxycarbonyloxy) -ethyl,

1- (methoxycarbonyloxy) propyl, 1- (ethoxycarbonyloxy) propyl, 1- (propoxycarbonyl)

Oxy) propyl, 1- (isopropyloxycarbonyloxy) propyl, 1- (butyloxycarbonyloxy) propyl, 1-

(isobutoxycarbonyloxy) propyl, 1- (pentyloxycarbonyloxy) propyl, 1- (hexyloxycarbonyloxy)

Propyl, 1- (methoxycarbonyloxy) butyl, 1- (ethoxycarbonyloxy) butyl, 1- (propoxyl)

Carbonyloxy) butyl, 1- (isopropyloxycarbonyloxy) butyl, 1- (butyloxycarbonyloxy) butyl,

1- (isobutoxycarbonyloxy) butyl, 1- (methoxycarbonyloxy) pentyl, 1- (ethoxycarbonyl)

Oxygen) pentyl, 1- (methoxycarbonyloxy) hexyl and 1- (ethoxycarbonyloxy) hexyl);

oxodioxolyl methyl (e.g., (5-phenyl-2-oxo-1, 3-dioxan)

Cyclopenten-4-yl) methyl, [5- (4-tolyl) -2-oxo-1, 3-di

Oxopenen-4-yl]methyl, [5- (4-methoxyphenyl) -2-oxo-1, 3

-dioxol-4-yl]methyl, [5- (4-fluorophenyl) -2-oxo-1,

3-dioxolen-4-yl]methyl, [5- (4-chlorophenyl) -2-oxo-1

3-dioxolen-4-yl methyl group, (2-oxo-1, 3-dioxolen-

4-yl) methyl, 5-methyl-2-oxo-1, 3-dioxolen-4-yl) methyl

Radical, (5-ethyl-2-oxo-1, 3-dioxol-4-yl) methyl, (5)

-propyl-2-oxo-1, 3-dioxolen-4-yl) methyl group, (5-propyl-

2-oxo-1, 3-dioxolen-4-yl) methyl, (5-isopropyl-2-oxy

1, 3-dioxolen-4-yl) methyl and (5-butyl-2-oxo-1,

3-dioxolen-4-yl) methyl);

2-benzo [ c]furanones, e.g. 2-benzo [ c]furanone, dimethyl 2-benzo [ c]

Furyl and dimethoxy 2-benzo [ c]furanonyl;

the above-mentioned aliphatic acyl group;

the above aromatic acyl group;

a succinic acid half-ester salt residue;

a phosphate residue;

ester-forming residues derived from e.g. amino acids;

1- (acyloxy) alkoxycarbonyl, such as pivaloyloxymethoxycarbonyl.

Among them, we prefer a carbonyloxyalkyl group.

The compound of formula (I) has asymmetric atoms in the molecule, and stereoisomers with asymmetric carbon atoms having R or S configuration exist. Stereoisomers whose asymmetric carbon atoms have the R or S configuration and mixtures thereof in any proportion are also included in the scope of the present invention.

Preferred compounds of the invention are compounds of the formula (I) wherein E represents methylene, and salts and esters thereof

(A1)R¹And R²The same or different, each represents an aryl group, an aromatic heterocyclic group or an aryl group substituted with 1 to 3 groups selected from the substituent α;

(B1)R²represents aryl or aryl substituted by 1 to 3 groups selected from substituent α;

(C1) a represents a carbonyl group;

(D1) b represents a single bond;

(E1) d is an oxygen atom;

(F1) g is an alkylene group having 1 to 4 carbon atoms;

(G1) g is an alkylene group having 2 or 3 carbon atoms;

(H1)R³represents an aromatic heterocyclic group or an aryl group substituted with 1 to 3 groups selected from the group consisting of substituents α;

(I1) l representsA group;

(J1)R⁴represents an aryl group or an aromatic heterocyclic group;

(K1)R⁵expression formula (I)Group (wherein R⁶Represents an alkyl group having 1 to 6 carbon atoms or an amine residue);

(L1)R⁵represents amino, amido or hydroxyl;

(M1)R⁴and R⁵Together with the carbon atom to which they are attached represent a cycloalkyl group having 5 to 10 ring atoms, which is unsubstituted or substituted by at least one substituent selected from the group consisting of substituent β, or a heterocyclyl group having a single nitrogen and/or oxygen and/or sulfur heteroatom, or R⁴And R⁵Together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclyl group as defined above fused to a carbocyclic aryl or aromatic heterocyclyl group, which aryl and aromatic heterocyclyl group is unsubstituted or substituted by at least one substituent selected from the group consisting of substituents α.

Further preferred compounds of the invention are compounds of the formula (I) wherein E represents a formula wherein n is an integer from 2 to 4, and salts and esters thereofA group, and (A2) R¹And R²The same or different, each represents an aryl group, an aromatic heterocyclic group or an aryl group substituted with 1 to 3 groups selected from the group consisting of the substituent α, (B2) R²Represents aryl or is represented byAryl substituted with 1 to 3 substituents selected from the group consisting of substituent α, (C2) A represents carbonyl;(D2) b represents a single bond; (E2) d represents an oxygen atom; (F2) g represents an alkylene group having 1 to 4 carbon atoms; (G2) g represents an alkylene group having 2 to 3 carbon atoms; (H2) r³Represents an aromatic heterocycle or an aryl group substituted with 1 to 3 substituents selected from the group consisting of the substituent α (I2) L represents a general formulaA group; (J2) r⁴Represents an aryl group or an aromatic heterocyclic group; (K2) r⁵Is represented by the general formulaRadical (in which R is⁶Represents an alkyl group having 1 to 6 carbon atoms or an amine residue); (L2) R⁵Represents amino, amido or hydroxyl; (M2) n is 2 or 3; (N2) N is 2; (O2) R⁴And R⁵Together with the carbon atom to which they are attached represent a cycloalkyl group having 5 to 10 ring atoms, which is unsubstituted or substituted by at least one substituent selected from the group consisting of substituent β, or a heterocyclyl group having a single nitrogen and/or oxygen and/or sulfur heteroatom, or R⁴And R⁵Together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclyl group as defined above fused to a carbocyclic aryl or aromatic heterocyclyl group, which aryl and aromatic heterocyclyl group is unsubstituted or substituted by at least one substituent selected from the group consisting of substituents α.

Further preferred compounds of the invention are compounds of the formula (I) wherein R is⁴And R⁵Together represent a group of the formulaAnd (A3) R¹Represents an aryl group, an aromatic heterocyclic group, or an aryl group substituted with 1 to 3 groups selected from the group consisting of the substituent α (B3)¹Represents aryl or from 1 to 3 substituents α¹Aryl substituted by the group of (1), substituent α¹Selected from the group consisting of alkyl groups having 1 to 6 carbon atoms, haloalkyl groups having 1 to 6 carbon atoms, and alkoxy groups having 1 to 6 carbon atoms; (C3) r²Represents an aryl group or an aryl group substituted with 1 to 3 groups selected from the group consisting of the substituent α, (D3) R²Represents an aryl group or an aryl group substituted by 1 to 3 halogen atoms;(E3) a represents a carbonyl group; (F3) B represents a single bond; (G3) D represents an oxygen atom; (H3) e represents C_1-4Alkylene or including C_3-6C of cycloalkane-1, 1-diyl group_3-8An alkylene group; (I3) e represents methylene, ethylene, dimethylmethylene, 1, 1-dimethylethylene, 2, 2-dimethylethylene, cyclopropane-1, 1-diyl, cyclobutane-1, 1-diyl, cyclopentane-1, 1-diyl, cyclohexane-1, 1-diyl, cyclopropane-1, 1-diyl methyl, cyclobutane-1, 1-diyl methyl, cyclopentane-1, 1-diyl methyl or cyclohexane-1, 1-diyl methyl; (J3) g represents C_1-4An alkylene group; (K3) g represents C_2-3An alkylene group; (L3) J represents C_1-4Alkylene, (M3) J represents methylene or ethylene, (N3) Ring Ar represents aryl, aryl substituted with 1to 3 substituents selected from the group consisting of a substituent α or aromatic heterocyclic group, (O3) Ring Ar represents aryl or aryl substituted with 1 to 3 substituents selected from the group consisting of a substituent α.

Examples of certain compounds of the present invention shown by the following formulas (I-1), (I-2) and (I-3) can be prepared as shown in the examples described below. The definitions of the substituents of these compounds correspond to tables 1, 2 and 3, that is, Table 1 relates to formula (I-1) and the like.

Each compound number in these tables includes 2 compounds, with G in one representing 1, 2-ethylene (which may be represented by the number and suffix "a" as specified in the tables) and G in the other representing 1, 3-propylene (which may be represented by the number and suffix "b" as specified in the tables).

Further, the compound Nos. 2-1537 to 2-3072 include those in which B may represent a single bond orCompounds of the groups which may be indicated by the suffix, α or β respectively, for example, Compound No.2-1537a α is Compound No.2-1537 in which G represents 1, 2-ethylene and B represents a single bond, Compound 2-537 αβ is Compound in which G represents 1, 2-ethylene and B represents a single bondCompound No.2-1537 of the groups, Compound No.2-1537B α is Compound No.2-1537 in which G represents 1, 3-propylene and B represents a single bond, Compound No.2-1537B β is Compound No.2-1537 in which G represents 1, 3-propylene and B represents a single bondCompound No.2-1537 of the group.

Names representing certain substituents are abbreviated as follows:

cBu cyclobutyl-1,1-diyl

cHx cyclohexyl-1, 1-diyl

Me methyl group

Ph phenyl

cPn cyclopentyl-1, 1-diyl

cPr cyclopropyl-1, 1-diyl

Single bond Single bond

Furthermore, the radical formula corresponding to the substituent symbol Sub-xx is as indicated on page 624 of the text

Page 631 shows:

TABLE 1

Compound (I) Serial number	R1	R2	A	B	Z
						1-1	Sub-33	3，4-diClPh	CH2	Single bond	Sub-1
1-2	Sub-33	3，4-diClPh	CH2	Single bond	Sub-2
						1-3	Sub-33	3，4-diClPh	CH2	Single bond	Sub-3
1-4	Sub-33	3，4-diClPh	CH2	Single bond	Sub-4
						1-5	Sub-33	3，4-diClPh	CH2	Single bond	Sub-5
1-6	Sub-33	3，4-diClPh	CH2	Single bond	Sub-6
						1-7	Sub-33	3，4-diClPh	CH2	Single bond	Sub-7
1-8	Sub-33	3，4-diClPh	CH2	Single bond	Sub-8
						1-9	Sub-33	3，4-diClPh	CH2	Single bond	Sub-9
1-10	Sub-33	3，4-diClPh	CH2	Single bond	Sub-10
						1-11	Sub-33	3，4-diClPh	CH2	Single bond	Sub-11
1-12	Sub-33	3，4-diClPh	CH2	Single bond	Sub-12
						1-13	Sub-33	3，4-diClPh	CH2	Single bond	Sub-13
1-14	Sub-33	3，4-diClPh	CH2	Single bond	Sub-14
						1-15	Sub-33	3，4-diClPh	CH2	Single bond	Sub-15
1-16	Sub-33	3，4-diClPh	CH2	Single bond	Sub-16
						1-17	Sub-33	3，4-diClPh	CH2	Single bond	Sub-17
1-18	Sub-33	3，4-diClPh	CH2	Single bond	Sub-18
						1-19	Sub-33	3，4-diClPh	CH2	Single bond	Sub-19
1-20	Sub-33	3，4-diClPh	CH2	Single bond	Sub-20
						1-21	Sub-33	3，4-diClPh	CH2	Single bond	Sub-21
1-22	Sub-33	3，4-diClPh	CH2	Single bond	Sub-22
						1-23	Sub-33	3，4-diClPh	CH2	Single bond	Sub-23
1-24	Sub-33	3，4-diClPh	CH2	Single bond	Sub-24
						1-25	Sub-33	3，4-diClPh	CH2	Single bond	Sub-25
1-26	Sub-33	3，4-diClPh	CH2	Single bond	Sub-26

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-27	Sub-33	3，4-diClPh	CH2	Single bond	Sub-27
1-28	Sub-33	3，4-diClPh	CH2	Single bond	Sub-28
						1-29	Sub-33	3，4-diClPh	CH2	Single bond	Sub-29
1-30	Sub-33	3，4-diClPh	CH2	Single bond	Sub-30
						1-31	Sub-33	3，4-diClPh	CH2	Single bond	Sub-31
1-32	Sub-33	3，4-diClPh	CH2	Single bond	Sub-32
						1-33	Sub-34	3，4-diClPh	CH2	Single bond	Sub-1
1-34	Sub-34	3，4-diClPh	CH2	Single bond	Sub-2
						1-35	Sub-34	3，4-diClPh	CH2	Single bond	Sub-3
1-36	Sub-34	3，4-diClPh	CH2	Single bond	Sub-4
						1-37	Sub-34	3，4-diClPh	CH2	Single bond	Sub-5
1-38	Sub-34	3，4-diClPh	CH2	Single bond	Sub-6
						1-39	Sub-34	3，4-diClPh	CH2	Single bond	Sub-7
1-40	Sub-34	3，4-diClPh	CH2	Single bond	Sub-8
						1-41	Sub-34	3，4-diClPh	CH2	Single bond	Sub-9
1-42	Sub-34	3，4-diClPh	CH2	Single bond	Sub-10
						1-43	Sub-34	3，4-diClPh	CH2	Single bond	Sub-11
1-44	Sub-34	3，4-diClPh	CH2	Single bond	Sub-12
						1-45	Sub-34	3，4-diClPh	CH2	Single bond	Sub-13
1-46	Sub-34	3，4-diClPh	CH2	Single bond	Sub-14
						1-47	Sub-34	3，4-diClPh	CH2	Single bond	Sub-15
1-48	Sub-34	3，4-diClPh	CH2	Single bond	Sub-16
						1-49	Sub-34	3，4-diClPh	CH2	Single bond	Sub-17
1-50	Sub-34	3，4-diClPh	CH2	Single bond	Sub-18
						1-51	Sub-34	3，4-diClPh	CH2	Single bond	Sub-19
1-52	Sub-34	3，4-diClPh	CH2	Single bond	Sub-20

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-53	Sub-34	3，4-diClPh	CH2	Single bond	Sub-21
1-54	Sub-34	3，4-diClPh	CH2	Single bond	Sub-22
						1-55	Sub-34	3，4-diClPh	CH2	Single bond	Sub-23
1-56	Sub-34	3，4-diClPh	CH2	Single bond	Sub-24
						1-57	Sub-34	3，4-diClPh	CH2	Single bond	Sub-25
1-58	Sub-34	3，4-diClPh	CH2	Single bond	Sub-26
						1-59	Sub-34	3，4-diClPh	CH2	Single bond	Sub-27
1-60	Sub-34	3，4-diClPh	CH2	Single bond	Sub-28
						1-61	Sub-34	3，4-diClPh	CH2	Single bond	Sub-29
1-62	Sub-34	3，4-diClPh	CH2	Single bond	Sub-30
						1-63	Sub-34	3，4-diClPh	CH2	Single bond	Sub-31
1-64	Sub-34	3，4-diClPh	CH2	Single bond	Sub-32
						1-65	Sub-35	3，4-diClPh	CH2	Single bond	Sub-1
1-66	Sub-35	3，4-diClPh	CH2	Single bond	Sub-2
						1-67	Sub-35	3，4-diClPh	CH2	Single bond	Sub-3
1-68	Sub-35	3，4-diClPh	CH2	Single bond	Sub-4
						1-69	Sub-35	3，4-diClPh	CH2	Single bond	Sub-5
1-70	Sub-35	3，4-diClPh	CH2	Single bond	Sub-6
						1-71	Sub-35	3，4-diClPh	CH2	Single bond	Sub-7
1-72	Sub-35	3，4-diClPh	CH2	Single bond	Sub-8
						1-73	Sub-35	3，4-diClPh	CH2	Single bond	Sub-9
1-74	Sub-35	3，4-diClPh	CH2	Single bond	Sub-10
						1-75	Sub-35	3，4-diClPh	CH2	Single bond	Sub-11
1-76	Sub-35	3，4-diClPh	CH2	Single bond	Sub-12
						1-77	Sub-35	3，4-diClPh	CH2	Single bond	Sub-13
1-78	Sub-35	3，4-diClPh	CH2	Single bond	Sub-14

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-79	Sub-35	3，4-diClPh	CH2	Single bond	Sub-15
1-80	Sub-35	3，4-diClPh	CH2	Single bond	Sub-16
						1-81	Sub-35	3，4-diClPh	CH2	Single bond	Sub-17
1-82	Sub-35	3，4-diClPh	CH2	Single bond	Sub-18
						1-83	Sub-35	3，4-diClPh	CH2	Single bond	Sub-19
1-84	Sub-35	3，4-diClPh	CH2	Single bond	Sub-20
						1-85	Sub-35	3，4-diClPh	CH2	Single bond	Sub-21
1-86	Sub-35	3，4-diClPh	CH2	Single bond	Sub-22
						1-87	Sub-35	3，4-diClPh	CH2	Single bond	Sub-23
1-88	Sub-35	3，4-diClPh	CH2	Single bond	Sub-24
						1-89	Sub-35	3，4-diClPh	CH2	Single bond	Sub-25
1-90	Sub-35	3，4-diClPh	CH2	Single bond	Sub-26
						1-91	Sub-35	3，4-diClPh	CH2	Single bond	Sub-27
1-92	Sub-35	3，4-diClPh	CH2	Single bond	Sub-28
						1-93	Sub-35	3，4-diClPh	CH2	Single bond	Sub-29
1-94	Sub-35	3，4-diClPh	CH2	Single bond	Sub-30
						1-95	Sub-35	3，4-diClPh	CH2	Single bond	Sub-31
1-96	Sub-35	3，4-diClPh	CH2	Single bond	Sub-32
						1-97	Sub-36	3，4-diClPh	CH2	Single bond	Sub-1
1-98	Sub-36	3，4-diClPh	CH2	Single bond	Sub-2
						1-99	Sub-36	3，4-diClPh	CH2	Single bond	Sub-3
1-100	Sub-36	3，4-diClPh	CH2	Single bond	Sub-4
						1-101	Sub-36	3，4-diClPh	CH2	Single bond	Sub-5
1-102	Sub-36	3，4-diClPh	CH2	Single bond	Sub-6
						1-103	Sub-36	3，4-diClPh	CH2	Single bond	Sub-7
1-104	Sub-36	3，4-diClPh	CH2	Single bond	Sub-8

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-105	Sub-36	3，4-diClPh	CH2	Single bond	Sub-9
1-106	Sub-36	3，4-diClPh	CH2	Single bond	Sub-10
						1-107	Sub-36	3，4-diClPh	CH2	Single bond	Sub-11
1-108	Sub-36	3，4-diClPh	CH2	Single bond	Sub-12
						1-109	Sub-36	3，4-diClPh	CH2	Single bond	Sub-13
1-110	Sub-36	3，4-diClPh	CH2	Single bond	Sub-14
						1-111	Sub-36	3，4-diClPh	CH2	Single bond	Sub-15
1-112	Sub-36	3，4-diClPh	CH2	Single bond	Sub-16
						1-113	Sub-36	3，4-diClPh	CH2	Single bond	Sub-17
1-114	Sub-36	3，4-diClPh	CH2	Single bond	Sub-18
						1-115	Sub-36	3，4-diClPh	CH2	Single bond	Sub-19
1-116	Sub-36	3，4-diClPh	CH2	Single bond	Sub-20
						1-117	Sub-36	3，4-diClPh	CH2	Single bond	Sub-21
1-118	Sub-36	3，4-diClPh	CH2	Single bond	Sub-22
						1-119	Sub-36	3，4-diClPh	CH2	Single bond	Sub-23
1-120	Sub-36	3，4-diClPh	CH2	Single bond	Sub-24
						1-121	Sub-36	3，4-diClPh	CH2	Single bond	Sub-25
1-122	Sub-36	3，4-diClPh	CH2	Single bond	Sub-26
						1-123	Sub-36	3，4-diClPh	CH2	Single bond	Sub-27
1-124	Sub-36	3，4-diClPh	CH2	Single bond	Sub-28
						1-125	Sub-36	3，4-diClPh	CH2	Single bond	Sub-29
1-126	Sub-36	3，4-diClPh	CH2	Single bond	Sub-30
						1-127	Sub-36	3，4-diClPh	CH2	Single bond	Sub-31
1-128	Sub-36	3，4-diClPh	CH2	Single bond	Sub-32
						1-129	Sub-37	3，4-diClPh	CH2	Single bond	Sub-1
1-130	Sub-37	3，4-diClPh	CH2	Single bond	Sub-2

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-131	Sub-37	3，4-diClPh	CH2	Single bond	Sub-3
1-132	Sub-37	3，4-diClPh	CH2	Single bond	Sub-4
						1-133	Sub-37	3，4-diClPh	CH2	Single bond	Sub-5
1-134	Sub-37	3，4-diClPh	CH2	Single bond	Sub-6
						1-135	Sub-37	3，4-diClPh	CH2	Single bond	Sub-7
1-136	Sub-37	3，4-diClPh	CH2	Single bond	Sub-8
						1-137	Sub-37	3，4-diClPh	CH2	Single bond	Sub-9
1-138	Sub-37	3，4-diClPh	CH2	Single bond	Sub-10
						1-139	Sub-37	3，4-diClPh	CH2	Single bond	Sub-11
1-140	Sub-37	3，4-diClPh	CH2	Single bond	Sub-12
						1-141	Sub-37	3，4-diClPh	CH2	Single bond	Sub-13
1-142	Sub-37	3，4-diClPh	CH2	Single bond	Sub-14
						1-143	Sub-37	3，4-diClPh	CH2	Single bond	Sub-15
1-144	Sub-37	3，4-diClPh	CH2	Single bond	Sub-16
						1-145	Sub-37	3，4-diClPh	CH2	Single bond	Sub-17
1-146	Sub-37	3，4-diClPh	CH2	Single bond	Sub-18
						1-147	Sub-37	3，4-diClPh	CH2	Single bond	Sub-19
1-148	Sub-37	3，4-diClPh	CH2	Single bond	Sub-20
						1-149	Sub-37	3，4-diClPh	CH2	Single bond	Sub-21
1-150	Sub-37	3，4-diClPh	CH2	Single bond	Sub-22
						1-151	Sub-37	3，4-diClPh	CH2	Single bond	Sub-23
1-152	Sub-37	3，4-diClPh	CH2	Single bond	Sub-24
						1-153	Sub-37	3，4-diClPh	CH2	Single bond	Sub-25
1-154	Sub-37	3，4-diClPh	CH2	Single bond	Sub-26
						1-155	Sub-37	3，4-diClPh	CH2	Single bond	Sub-27
1-156	Sub-37	3，4-diClPh	CH2	Single bond	Sub-28

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-157	Sub-37	3，4-diClPh	CH2	Single bond	Sub-29
1-158	Sub-37	3，4-diClPh	CH2	Single bond	Sub-30
						1-159	Sub-37	3，4-diClPh	CH2	Single bond	Sub-31
1-160	Sub-37	3，4-diClPh	CH2	Single bond	Sub-32
						1-161	Sub-38	3，4-diClPh	CH2	Single bond	Sub-1
1-162	Sub-38	3，4-diClPh	CH2	Single bond	Sub-2
						1-163	Sub-38	3，4-diClPh	CH2	Single bond	Sub-3
1-164	Sub-38	3，4-diClPh	CH2	Single bond	Sub-4
						1-165	Sub-38	3，4-diClPh	CH2	Single bond	Sub-5
1-166	Sub-38	3，4-diClPh	CH2	Single bond	Sub-6
						1-167	Sub-38	3，4-diClPh	CH2	Single bond	Sub-7
1-168	Sub-38	3，4-diClPh	CH2	Single bond	Sub-8
						1-169	Sub-38	3，4-diClPh	CH2	Single bond	Sub-9
1-170	Sub-38	3，4-diClPh	CH2	Single bond	Sub-10
						1-171	Sub-38	3，4-diClPh	CH2	Single bond	Sub-11
1-172	Sub-38	3，4-diClPh	CH2	Single bond	Sub-12
						1-173	Sub-38	3，4-diClPh	CH2	Single bond	Sub-13
1-174	Sub-38	3，4-diClPh	CH2	Single bond	Sub-14
						1-175	Sub-38	3，4-diClPh	CH2	Single bond	Sub-15
1-176	Sub-38	3，4-diClPh	CH2	Single bond	Sub-16
						1-177	Sub-38	3，4-diClPh	CH2	Single bond	Sub-17
1-178	Sub-38	3，4-diClPh	CH2	Single bond	Sub-18
						1-179	Sub-38	3，4-diClPh	CH2	Single bond	Sub-19
1-180	Sub-38	3，4-diClPh	CH2	Single bond	Sub-20
						1-181	Sub-38	3，4-diClPh	CH2	Single bond	Sub-21
1-182	Sub-38	3，4-diClPh	CH2	Single bond	Sub-22

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-183	Sub-38	3，4-diClPh	CH2	Single bond	Sub-23
1-184	Sub-38	3，4-diClPh	CH2	Single bond	Sub-24
						1-185	Sub-38	3，4-diClPh	CH2	Single bond	Sub-25
1-186	Sub-38	3，4-diClPh	CH2	Single bond	Sub-26
						1-187	Sub-38	3，4-diClPh	CH2	Single bond	Sub-27
1-188	Sub-38	3，4-diClPh	CH2	Single bond	Sub-28
						1-189	Sub-38	3，4-diClPh	CH2	Single bond	Sub-29
1-190	Sub-38	3，4-diClPh	CH2	Single bond	Sub-30
						1-191	Sub-38	3，4-diClPh	CH2	Single bond	Sub-31
1-192	Sub-38	3，4-diClPh	CH2	Single bond	Sub-32
						1-193	Sub-39	3，4-diClPh	CH2	Single bond	Sub-1
1-194	Sub-39	3，4-diClPh	CH2	Single bond	Sub-2
						1-195	Sub-39	3，4-diClPh	CH2	Single bond	Sub-3
1-196	Sub-39	3，4-diClPh	CH2	Single bond	Sub-4
						1-197	Sub-39	3，4-diClPh	CH2	Single bond	Sub-5
1-198	Sub-39	3，4-diClPh	CH2	Single bond	Sub-6
						1-199	Sub-39	3，4-diClPh	CH2	Single bond	Sub-7
1-200	Sub-39	3，4-diClPh	CH2	Single bond	Sub-8
						1-201	Sub-39	3，4-diClPh	CH2	Single bond	Sub-9
1-202	Sub-39	3，4-diClPh	CH2	Single bond	Sub-10
						1-203	Sub-39	3，4-diClPh	CH2	Single bond	Sub-11
1-204	Sub-39	3，4-diClPh	CH2	Single bond	Sub-12
						1-205	Sub-39	3，4-diClPh	CH2	Single bond	Sub-13
1-206	Sub-39	3，4-diClPh	CH2	Single bond	Sub-14
						1-207	Sub-39	3，4-diClPh	CH2	Single bond	Sub-15
1-208	Sub-39	3，4-diClPh	CH2	Single bond	Sub-16

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-209	Sub-39	3，4-diClPh	CH2	Single bond	Sub-17
1-210	Sub-39	3，4-diClPh	CH2	Single bond	Sub-18
						1-211	Sub-39	3，4-diClPh	CH2	Single bond	Sub-19
1-212	Sub-39	3，4-diClPh	CH2	Single bond	Sub-20
						1-213	Sub-39	3，4-diClPh	CH2	Single bond	Sub-21
1-214	Sub-39	3，4-diClPh	CH2	Single bond	Sub-22
						1-215	Sub-39	3，4-diClPh	CH2	Single bond	Sub-23
1-216	Sub-39	3，4-diClPh	CH2	Single bond	Sub-24
						1-217	Sub-39	3，4-diClPh	CH2	Single bond	Sub-25
1-218	Sub-39	3，4-diClPh	CH2	Single bond	Sub-26
						1-219	Sub-39	3，4-diClPh	CH2	Single bond	Sub-27
1-220	Sub-39	3，4-diClPh	CH2	Single bond	Sub-28
						1-221	Sub-39	3，4-diClPh	CH2	Single bond	Sub-29
1-222	Sub-39	3，4-diClPh	CH2	Single bond	Sub-30
						1-223	Sub-39	3，4-diClPh	CH2	Single bond	Sub-31
1-224	Sub-39	3，4-diClPh	CH2	Single bond	Sub-32
						1-225	Sub-40	3，4-diClPh	CH2	Single bond	Sub-1
1-226	Sub-40	3，4-diClPh	CH2	Single bond	Sub-2
						1-227	Sub-40	3，4-diClPh	CH2	Single bond	Sub-3
1-228	Sub-40	3，4-diClPh	CH2	Single bond	Sub-4
						1-229	Sub-40	3，4-diClPh	CH2	Single bond	Sub-5
1-230	Sub-40	3，4-diClPh	CH2	Single bond	Sub-6
						1-231	Sub-40	3，4-diClPh	CH2	Single bond	Sub-7
1-232	Sub-40	3，4-diClPh	CH2	Single bond	Sub-8
						1-233	Sub-40	3，4-diClPh	CH2	Single bond	Sub-9
1-234	Sub-40	3，4-diClPh	CH2	Single bond	Sub-10

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-235	Sub-40	3，4-diClPh	CH2	Single bond	Sub-11
1-236	Sub-40	3，4-diClPh	CH2	Single bond	Sub-12
						1-237	Sub-40	3，4-diClPh	CH2	Single bond	Sub-13
1-238	Sub-40	3，4-diClPh	CH2	Single bond	Sub-14
						1-239	Sub-40	3，4-diClPh	CH2	Single bond	Sub-15
1-240	Sub-40	3，4-diClPh	CH2	Single bond	Sub-16
						1-241	Sub-40	3，4-diClPh	CH2	Single bond	Sub-17
1-242	Sub-40	3，4-diClPh	CH2	Single bond	Sub-18
						1-243	Sub-40	3，4-diClPh	CH2	Single bond	Sub-19
1-244	Sub-40	3，4-diClPh	CH2	Single bond	Sub-20
						1-245	Sub-40	3，4-diClPh	CH2	Single bond	Sub-21
1-246	Sub-40	3，4-diClPh	CH2	Single bond	Sub-22
						1-247	Sub-40	3，4-diClPh	CH2	Single bond	Sub-23
1-248	Sub-40	3，4-diClPh	CH2	Single bond	Sub-24
						1-249	Sub-40	3，4-diClPh	CH2	Single bond	Sub-25
1-250	Sub-40	3，4-diClPh	CH2	Single bond	Sub-26
						1-251	Sub-40	3，4-diClPh	CH2	Single bond	Sub-27
1-252	Sub-40	3，4-diClPh	CH2	Single bond	Sub-28
						1-253	Sub-40	3，4-diClPh	CH2	Single bond	Sub-29
1-254	Sub-40	3，4-diClPh	CH2	Single bond	Sub-30
						1-255	Sub-40	3，4-diClPh	CH2	Single bond	Sub-31
1-256	Sub-40	3，4-diClPh	CH2	Single bond	Sub-32
						1-257	Sub-41	3，4-diClPh	CH2	Single bond	Sub-1
1-258	Sub-41	3，4-diClPh	CH2	Single bond	Sub-2
						1-259	Sub-41	3，4-diClPh	CH2	Single bond	Sub-3
1-260	Sub-41	3，4-diClPh	CH2	Single bond	Sub-4

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-261	Sub-41	3，4-diClPh	CH2	Single bond	Sub-5
1-262	Sub-41	3，4-diClPh	CH2	Single bond	Sub-6
						1-263	Sub-41	3，4-diClPh	CH2	Single bond	Sub-7
1-264	Sub-41	3，4-diClPh	CH2	Single bond	Sub-8
						1-265	Sub-41	3，4-diClPh	CH2	Single bond	Sub-9
1-266	Sub-41	3，4-diClPh	CH2	Single bond	Sub-10
						1-267	Sub-41	3，4-diClPh	CH2	Single bond	Sub-11
1-268	Sub-41	3，4-diClPh	CH2	Single bond	Sub-12
						1-269	Sub-41	3，4-diClPh	CH2	Single bond	Sub-13
1-270	Sub-41	3，4-diClPh	CH2	Single bond	Sub-14
						1-271	Sub-41	3，4-diClPh	CH2	Single bond	Sub-15
1-272	Sub-41	3，4-diClPh	CH2	Single bond	Sub-16
						1-273	Sub-41	3，4-diClPh	CH2	Single bond	Sub-17
1-274	Sub-41	3，4-diClPh	CH2	Single bond	Sub-18
						1-275	Sub-41	3，4-diClPh	CH2	Single bond	Sub-19
1-276	Sub-41	3，4-diClPh	CH2	Single bond	Sub-20
						1-277	Sub-41	3，4-diClPh	CH2	Single bond	Sub-21
1-278	Sub-41	3，4-diClPh	CH2	Single bond	Sub-22
						1-279	Sub-41	3，4-diClPh	CH2	Single bond	Sub-23
1-280	Sub-41	3，4-diClPh	CH2	Single bond	Sub-24
						1-281	Sub-41	3，4-diClPh	CH2	Single bond	Sub-25
1-282	Sub-41	3，4-diClPh	CH2	Single bond	Sub-26
						1-283	Sub-41	3，4-diClPh	CH2	Single bond	Sub-27
1-284	Sub-41	3，4-diClPh	CH2	Single bond	Sub-28
						1-285	Sub-41	3，4-diClPh	CH2	Single bond	Sub-29
1-286	Sub-41	3，4-diClPh	CH2	Single bond	Sub-30

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-287	Sub-41	3，4-diClPh	CH2	Single bond	Sub-31
1-288	Sub-41	3，4-diClPh	CH2	Single bond	Sub-32
						1-289	Sub-42	3，4-diClPh	CH2	Single bond	Sub-1
1-290	Sub-42	3，4-diClPh	CH2	Single bond	Sub-2
						1-291	Sub-42	3，4-diClPh	CH2	Single bond	Sub-3
1-292	Sub-42	3，4-diClPh	CH2	Single bond	Sub-4
						1-293	Sub-42	3，4-diClPh	CH2	Single bond	Sub-5
1-294	Sub-42	3，4-diClPh	CH2	Single bond	Sub-6
						1-295	Sub-42	3，4-diClPh	CH2	Single bond	Sub-7
1-296	Sub-42	3，4-diClPh	CH2	Single bond	Sub-8
						1-297	Sub-42	3，4-diClPh	CH2	Single bond	Sub-9
1-298	Sub-42	3，4-diClPh	CH2	Single bond	Sub-10
						1-299	Sub-42	3，4-diClPh	CH2	Single bond	Sub-11
1-300	Sub-42	3，4-diClPh	CH2	Single bond	Sub-12
						1-301	Sub-42	3，4-diClPh	CH2	Single bond	Sub-13
1-302	Sub-42	3，4-diClPh	CH2	Single bond	Sub-14
						1-303	Sub-42	3，4-diClPh	CH2	Single bond	Sub-15
1-304	Sub-42	3，4-diClPh	CH2	Single bond	Sub-16
						1-305	Sub-42	3，4-diClPh	CH2	Single bond	Sub-17
1-306	Sub-42	3，4-diClPh	CH2	Single bond	Sub-18
						1-307	Sub-42	3，4-diClPh	CH2	Single bond	Sub-19
1-308	Sub-42	3，4-diClPh	CH2	Single bond	Sub-20
						1-309	Sub-42	3，4-diClPh	CH2	Single bond	Sub-21
1-310	Sub-42	3，4-diClPh	CH2	Single bond	Sub-22
						1-311	Sub-42	3，4-diClPh	CH2	Single bond	Sub-23
1-312	Sub-42	3，4-diClPh	CH2	Single bond	Sub-24

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-313	Sub-42	3，4-diClPh	CH2	Single bond	Sub-25
1-314	Sub-42	3，4-diClPh	CH2	Single bond	Sub-26
						1-315	Sub-42	3，4-diClPh	CH2	Single bond	Sub-27
1-316	Sub-42	3，4-diClPh	CH2	Single bond	Sub-28
						1-317	Sub-42	3，4-diClPh	CH2	Single bond	Sub-29
1-318	Sub-42	3，4-diClPh	CH2	Single bond	Sub-30
						1-319	Sub-42	3，4-diClPh	CH2	Single bond	Sub-31
1-320	Sub-42	3，4-diClPh	CH2	Single bond	Sub-32
						1-321	Sub-43	3，4-diClPh	CH2	Single bond	Sub-1
1-322	Sub-43	3，4-diClPh	CH2	Single bond	Sub-2
						1-323	Sub-43	3，4-diClPh	CH2	Single bond	Sub-3
1-324	Sub-43	3，4-diClPh	CH2	Single bond	Sub-4
						1-325	Sub-43	3，4-diClPh	CH2	Single bond	Sub-5
1-326	Sub-43	3，4-diClPh	CH2	Single bond	Sub-6
						1-327	Sub-43	3，4-diClPh	CH2	Single bond	Sub-7
1-328	Sub-43	3，4-diClPh	CH2	Single bond	Sub-8
						1-329	Sub-43	3，4-diClPh	CH2	Single bond	Sub-9
1-330	Sub-43	3，4-diClPh	CH2	Single bond	Sub-10
						1-331	Sub-43	3，4-diClPh	CH2	Single bond	Sub-11
1-332	Sub-43	3，4-diClPh	CH2	Single bond	Sub-12
						1-333	Sub-43	3，4-diClPh	CH2	Single bond	Sub-13
1-334	Sub-43	3，4-diClPh	CH2	Single bond	Sub-14
						1-335	Sub-43	3，4-diClPh	CH2	Single bond	Sub-15
1-336	Sub-43	3，4-diClPh	CH2	Single bond	Sub-16
						1-337	Sub-43	3，4-diClPh	CH2	Single bond	Sub-17
1-338	Sub-43	3，4-diClPh	CH2	Single bond	Sub-18

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-339	Sub-43	3，4-diClPh	CH2	Single bond	Sub-19
1-340	Sub-43	3，4-diClPh	CH2	Single bond	Sub-20
						1-341	Sub-43	3，4-diClPh	CH2	Single bond	Sub-21
1-342	Sub-43	3，4-diClPh	CH2	Single bond	Sub-22
						1-343	Sub-43	3，4-diClPh	CH2	Single bond	Sub-23
1-344	Sub-43	3，4-diClPh	CH2	Single bond	Sub-24
						1-345	Sub-43	3，4-diClPh	CH2	Single bond	Sub-25
1-346	Sub-43	3，4-diClPh	CH2	Single bond	Sub-26
						1-347	Sub-43	3，4-diClPh	CH2	Single bond	Sub-27
1-348	Sub-43	3，4-diClPh	CH2	Single bond	Sub-28
						1-349	Sub-43	3，4-diClPh	CH2	Single bond	Sub-29
1-350	Sub-43	3，4-diClPh	CH2	Single bond	Sub-30
						1-351	Sub-43	3，4-diClPh	CH2	Single bond	Sub-31
1-352	Sub-43	3，4-diClPh	CH2	Single bond	Sub-32
						1-353	Sub-44	3，4-diClPh	CH2	Single bond	Sub-1
1-354	Sub-44	3，4-diClPh	CH2	Single bond	Sub-2
						1-355	Sub-44	3，4-diClPh	CH2	Single bond	Sub-3
1-356	Sub-44	3，4-diClPh	CH2	Single bond	Sub-4
						1-357	Sub-44	3，4-diClPh	CH2	Single bond	Sub-5
1-358	Sub-44	3，4-diClPh	CH2	Single bond	Sub-6
						1-359	Sub-44	3，4-diClPh	CH2	Single bond	Sub-7
1-360	Sub-44	3，4-diClPh	CH2	Single bond	Sub-8
						1-361	Sub-44	3，4-diClPh	CH2	Single bond	Sub-9
1-362	Sub44	3，4-diClPh	CH2	Single bond	Sub-10
						1-363	Sub-44	3，4-diClPh	CH2	Single bond	Sub-11
1-364	Sub-44	3，4-diClPh	CH2	Single bond	Sub-12

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-365	Sub-44	3，4-diClPh	CH2	Single bond	Sub-13
1-366	Sub-44	3，4-diClPh	CH2	Single bond	Sub-14
						1-367	Sub-44	3，4-diClPh	CH2	Single bond	Sub-15
1-368	Sub-44	3，4-diClPh	CH2	Single bond	Sub-16
						1-369	Sub-44	3，4-diClPh	CH2	Single bond	Sub-17
1-370	Sub-44	3，4-diClPh	CH2	Single bond	Sub-18
						1-371	Sub-44	3，4-diClPh	CH2	Single bond	Sub-19
1-372	Sub-44	3，4-diClPh	CH2	Single bond	Sub-20
						1-373	Sub-44	3，4-diClPh	CH2	Single bond	Sub-21
1-374	Sub-44	3，4-diClPh	CH2	Single bond	Sub-22
						1-375	Sub-44	3，4-diClPh	CH2	Single bond	Sub-23
1-376	Sub-44	3，4-diClPh	CH2	Single bond	Sub-24
						1-377	Sub-44	3，4-diClPh	CH2	Single bond	Sub-25
1-378	Sub-44	3，4-diClPh	CH2	Single bond	Sub-26
						1-379	Sub-44	3，4-diClPh	CH2	Single bond	Sub-27
1-380	Sub-44	3，4-diClPh	CH2	Single bond	Sub-28
						1-381	Sub-44	3，4-diClPh	CH2	Single bond	Sub-29
1-382	Sub-44	3，4-diClPh	CH2	Single bond	Sub-30
						1-383	Sub-44	3，4-diClPh	CH2	Single bond	Sub-31
1-384	Sub-44	3，4-diClPh	CH2	Single bond	Sub-32
						1-385	Sub-45	3，4-diClPh	CH2	Single bond	Sub-1
1-386	Sub-45	3，4-diClPh	CH2	Single bond	Sub-2
						1-387	Sub-45	3，4-diClPh	CH2	Single bond	Sub-3
1-388	Sub-45	3，4-diClPh	CH2	Single bond	Sub-4
						1-389	Sub-45	3，4-diClPh	CH2	Single bond	Sub-5
1-390	Sub-45	3，4-diClPh	CH2	Single bond	Sub-6

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-391	Sub-45	3，4-diClPh	CH2	Single bond	Sub-7
1-392	Sub-45	3，4-diClPh	CH2	Single bond	Sub-8
						1-393	Sub-45	3，4-diClPh	CH2	Single bond	Sub-9
1-394	Sub-45	3，4-diClPh	CH2	Single bond	Sub-10
						1-395	Sub-45	3，4-diClPh	CH2	Single bond	Sub-11
1-396	Sub-45	3，4-diClPh	CH2	Single bond	Sub-12
						1-397	Sub-45	3，4-diClPh	CH2	Single bond	Sub-13
1-398	Sub-45	3，4-diClPh	CH2	Single bond	Sub-14
						1-399	Sub-45	3，4-diClPh	CH2	Single bond	Sub-15
1-400	Sub-45	3，4-diClPh	CH2	Single bond	Sub-16
						1-401	Sub-45	3，4-diClPh	CH2	Single bond	Sub-17
1-402	Sub-45	3，4-diClPh	CH2	Single bond	Sub-18
						1-403	Sub-45	3，4-diClPh	CH2	Single bond	Sub-19
1-404	Sub-45	3，4-diClPh	CH2	Single bond	Sub-20
						1-405	Sub-45	3，4-diClPh	CH2	Single bond	Sub-21
1-406	Sub-45	3，4-diClPh	CH2	Single bond	Sub-22
						1-407	Sub-45	3，4-diClPh	CH2	Single bond	Sub-23
1-408	Sub-45	3，4-diClPh	CH2	Single bond	Sub-24
						1-409	Sub-45	3，4-diClPh	CH2	Single bond	Sub-25
1-410	Sub-45	3，4-diClPh	CH2	Single bond	Sub-26
						1-411	Sub-45	3，4-diClPh	CH2	Single bond	Sub-27
1-412	Sub-45	3，4-diClPh	CH2	Single bond	Sub-28
						1-413	Sub-45	3，4-diClPh	CH2	Single bond	Sub-29
1-414	Sub-45	3，4-diClPh	CH2	Single bond	Sub-30
						1-415	Sub-45	3，4-diClPh	CH2	Single bond	Sub-31
1-416	Sub-45	3，4-diClPh	CH2	Single bond	Sub-32

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-417	Sub-46	3，4-diClPh	CH2	Single bond	Sub-1
1-418	Sub-46	3，4-diClPh	CH2	Single bond	Sub-2
						1-419	Sub-46	3，4-diClPh	CH2	Single bond	Sub-3
1-420	Sub-46	3，4-diClPh	CH2	Single bond	Sub-4
						1-421	Sub-46	3，4-diClPh	CH2	Single bond	Sub-5
1-422	Sub-46	3，4-diClPh	CH2	Single bond	Sub-6
						1-423	Sub-46	3，4-diClPh	CH2	Single bond	Sub-7
1-424	Sub-46	3，4-diClPh	CH2	Single bond	Sub-8
						1-425	Sub-46	3，4-diClPh	CH2	Single bond	Sub-9
1-426	Sub-46	3，4-diClPh	CH2	Single bond	Sub-10
						1-427	Sub-46	3，4-diClPh	CH2	Single bond	Sub-11
1-428	Sub-46	3，4-diClPh	CH2	Single bond	Sub-12
						1-429	Sub-46	3，4-diClPh	CH2	Single bond	Sub-13
1-430	Sub-46	3，4-diClPh	CH2	Single bond	Sub-14
						1-431	Sub-46	3，4-diClPh	CH2	Single bond	Sub-15
1-432	Sub-46	3，4-diClPh	CH2	Single bond	Sub-16
						1-433	Sub-46	3，4-diClPh	CH2	Single bond	Sub-17
1-434	Sub-46	3，4-diClPh	CH2	Single bond	Sub-18
						1-435	Sub-46	3，4-diClPh	CH2	Single bond	Sub-19
1-436	Sub-46	3，4-diClPh	CH2	Single bond	Sub-20
						1-437	Sub-46	3，4-diClPh	CH2	Single bond	Sub-21
1-438	Sub-46	3，4-diClPh	CH2	Single bond	Sub-22
						1-439	Sub-46	3，4-diClPh	CH2	Single bond	Sub-23
1-440	Sub-46	3，4-diClPh	CH2	Single bond	Sub-24
						1-441	Sub-46	3，4-diClPh	CH2	Single bond	Sub-25
1-442	Sub-46	3，4-diClPh	CH2	Single bond	Sub-26

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-443	Sub-46	3，4-diClPh	CH2	Single bond	Sub-27
1-444	Sub-46	3，4-diClPh	CH2	Single bond	Sub-28
						1-445	Sub-46	3，4-diClPh	CH2	Single bond	Sub-29
1-446	Sub-46	3，4-diClPh	CH2	Single bond	Sub-30
						1-447	Sub-46	3，4-diClPh	CH2	Single bond	Sub-31
1-448	Sub-46	3，4-diClPh	CH2	Single bond	Sub-32
						1-449	Sub-47	3，4-diClPh	CH2	Single bond	Sub-1
1-450	Sub-47	3，4-diClPh	CH2	Single bond	Sub-2
						1-451	Sub-47	3，4-diClPh	CH2	Single bond	Sub-3
1-452	Sub-47	3，4-diClPh	CH2	Single bond	Sub-4
						1-453	Sub-47	3，4-diClPh	CH2	Single bond	Sub-5
1-454	Sub-47	3，4-diClPh	CH2	Single bond	Sub-6
						1-455	Sub-47	3，4-diClPh	CH2	Single bond	Sub-7
1-456	Sub-47	3，4-diClPh	CH2	Single bond	Sub-8
						1-457	Sub-47	3，4-diClPh	CH2	Single bond	Sub-9
1-458	Sub-47	3，4-diClPh	CH2	Single bond	Sub-10
						1-459	Sub-47	3，4-diClPh	CH2	Single bond	Sub-11
1-460	Sub-47	3，4-diClPh	CH2	Single bond	Sub-12
						1-461	Sub-47	3，4-diClPh	CH2	Single bond	Sub-13
1-462	Sub-47	3，4-diClPh	CH2	Single bond	Sub-14
						1-463	Sub-47	3，4-diClPh	CH2	Single bond	Sub-15
1-464	Sub-47	3，4-diClPh	CH2	Single bond	Sub-16
						1-465	Sub-47	3，4-diClPh	CH2	Single bond	Sub-17
1-466	Sub-47	3，4-diClPh	CH2	Single bond	Sub-18
						1-467	Sub-47	3，4-diClPh	CH2	Single bond	Sub-19
1-468	Sub-47	3，4-diClPh	CH2	Single bond	Sub-20

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-469	Sub-47	3，4-diClPh	CH2	Single bond	Sub-21
1-470	Sub-47	3，4-diClPh	CH2	Single bond	Sub-22
						1-471	Sub-47	3，4-diClPh	CH2	Single bond	Sub-23
1-472	Sub-47	3，4-diClPh	CH2	Single bond	Sub-24
						1-473	Sub-47	3，4-diClPh	CH2	Single bond	Sub-25
1-474	Sub-47	3，4-diClPh	CH2	Single bond	Sub-26
						1-475	Sub-47	3，4-diClPh	CH2	Single bond	Sub-27
1-476	Sub-47	3，4-diClPh	CH2	Single bond	Sub-28
						1-477	Sub-47	3，4-diClPh	CH2	Single bond	Sub-29
1-478	Sub-47	3，4-diClPh	CH2	Single bond	Sub-30
						1-479	Sub-47	3，4-diClPh	CH2	Single bond	Sub-31
1-480	Sub-47	3，4-diClPh	CH2	Single bond	Sub-32
						1-481	Sub-48	3，4-diClPh	CH2	Single bond	Sub-1
1-482	Sub-48	3，4-diClPh	CH2	Single bond	Sub-2
						1-483	Sub-48	3，4-diClPh	CH2	Single bond	Sub-3
1-484	Sub-48	3，4-diClPh	CH2	Single bond	Sub-4
						1-485	Sub-48	3，4-diClPh	CH2	Single bond	Sub-5
1-486	Sub-48	3，4-diClPh	CH2	Single bond	Sub-6
						1-487	Sub-48	3，4-diClPh	CH2	Single bond	Sub-7
1-488	Sub-48	3，4-diClPh	CH2	Single bond	Sub-8
						1-489	Sub-48	3，4-diClPh	CH2	Single bond	Sub-9
1-490	Sub-48	3，4-diClPh	CH2	Single bond	Sub-10
						1-491	Sub-48	3，4-diClPh	CH2	Single bond	Sub-11
1-492	Sub-48	3，4-diClPh	CH2	Single bond	Sub-12
						1-493	Sub-48	3，4-diClPh	CH2	Single bond	Sub-13
1-494	Sub-48	3，4-diClPh	CH2	Single bond	Sub-14

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-495	Sub-48	3，4-diClPh	CH2	Single bond	Sub-15
1-496	Sub-48	3，4-diClPh	CH2	Single bond	Sub-16
						1-497	Sub-48	3，4-diClPh	CH2	Single bond	Sub-17
1-498	Sub-48	3，4-diClPh	CH2	Single bond	Sub-18
						1-499	Sub-48	3，4-diClPh	CH2	Single bond	Sub-19
1-500	Sub-48	3，4-diClPh	CH2	Single bond	Sub-20
						1-501	Sub-48	3，4-diClPh	CH2	Single bond	Sub-21
1-502	Sub-48	3，4-diClPh	CH2	Single bond	Sub-22
						1-503	Sub-48	3，4-diClPh	CH2	Single bond	Sub-23
1-504	Sub-48	3，4-diClPh	CH2	Single bond	Sub-24
						1-505	Sub-48	3，4-diClPh	CH2	Single bond	Sub-25
1-506	Sub-48	3，4-diClPh	CH2	Single bond	Sub-26
						1-507	Sub-48	3，4-diClPh	CH2	Single bond	Sub-27
1-508	Sub-48	3，4-diClPh	CH2	Single bond	Sub-28
						1-509	Sub-48	3，4-diClPh	CH2	Single bond	Sub-29
1-510	Sub-48	3，4-diClPh	CH2	Single bond	Sub-30
						1-511	Sub-48	3，4-diClPh	CH2	Single bond	Sub-31
1-512	Sub-48	3，4-diClPh	CH2	Single bond	Sub-32
						1-513	Sub-49	3，4-diClPh	CH2	Single bond	Sub-1
1-514	Sub-49	3，4-diClPh	CH2	Single bond	Sub-2
						1-515	Sub-49	3，4-diClPh	CH2	Single bond	Sub-3
1-516	Sub-49	3，4-diClPh	CH2	Single bond	Sub-4
						1-517	Sub-49	3，4-diClPh	CH2	Single bond	Sub-5
1-518	Sub-49	3，4-diClPh	CH2	Single bond	Sub-6
						1-519	Sub-49	3，4-diClPh	CH2	Single bond	Sub-7
1-520	Sub-49	3，4-diClPh	CH2	Single bond	Sub-8

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-521	Sub-49	3，4-diClPh	CH2	Single bond	Sub-9
1-522	Sub-49	3，4-diClPh	CH2	Single bond	Sub-10
						1-523	Sub-49	3，4-diClPh	CH2	Single bond	Sub-11
1-524	Sub-49	3，4-diClPh	CH2	Single bond	Sub-12
						1-525	Sub-49	3，4-diClPh	CH2	Single bond	Sub-13
1-526	Sub-49	3，4-diClPh	CH2	Single bond	Sub-14
						1-527	Sub-49	3，4-diClPh	CH2	Single bond	Sub-15
1-528	Sub-49	3，4-diClPh	CH2	Single bond	Sub-16
						1-529	Sub-49	3，4-diClPh	CH2	Single bond	Sub-17
1-530	Sub-49	3，4-diClPh	CH2	Single bond	Sub-18
						1-531	Sub-49	3，4-diClPh	CH2	Single bond	Sub-19
1-532	Sub-49	3，4-diClPh	CH2	Single bond	Sub-20
						1-533	Sub-49	3，4-diClPh	CH2	Single bond	Sub-21
1-534	Sub-49	3，4-diClPh	CH2	Single bond	Sub-22
						1-535	Sub-49	3，4-diClPh	CH2	Single bond	Sub-23
1-536	Sub-49	3，4-diClPh	CHl2	Single bond	Sub-24
						1-537	Sub-49	3，4-diClPh	CH2	Single bond	Sub-25
1-538	Sub-49	3，4-diClPh	CH2	Single bond	Sub-26
						1-539	Sub-49	3，4-diClPh	CH2	Single bond	Sub-27
1-540	Sub-49	3，4-diClPh	CH2	Single bond	Sub-28
						1-541	Sub-49	3，4-diClPh	CH2	Single bond	Sub-29
1-542	Sub-49	3，4-diClPh	CH2	Single bond	Sub-30
						1-543	Sub-49	3，4-diClPh	CH2	Single bond	Sub-31
1-544	Sub-49	3，4-diClPh	CH2	Single bond	Sub-32
						1-545	Sub-50	3，4-diClPh	CH2	SheetKey with a key body	Sub-1
1-546	Sub-50	3，4-diClPh	CH2	Single bond	Sub-2

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-547	Sub-50	3，4-diClPh	CH2	Single bond	Sub-3
1-548	Sub-50	3，4-diClPh	CH2	Single bond	Sub-4
						1-549	Sub-50	3，4-diClPh	CH2	Single bond	Sub-5
1-550	Sub-50	3，4-diClPh	CH2	Single bond	Sub-6
						1-551	Sub-50	3，4-diCiPh	CH2	Single bond	Sub-7
1-552	Sub-50	3，4-diClPh	CH2	Single bond	Sub-8
						1-553	Sub-50	3，4-diClPh	CH2	Single bond	Sub-9
1-554	Sub-50	3，4-diClPh	CH2	Single bond	Sub-10
						1-555	Sub-50	3，4-diClPh	CH2	Single bond	Sub-11
1-556	Sub-50	3，4-diClPh	CH2	Single bond	Sub-12
						1-557	Sub-50	3，4-diClPh	CH2	Single bond	Sub-13
1-558	Sub-50	3，4-diClPh	CH2	Single bond	Sub-14
						1-559	Sub-50	3，4-diClPh	CH2	Single bond	Sub-15
1-560	Sub-50	3，4-diClPh	CH2	Single bond	Sub-16
						1-561	Sub-50	3，4-diClPh	CH2	Single bond	Sub-17
1-562	Sub-50	3，4-diClPh	CH2	Single bond	Sub-18
						1-563	Sub-50	3，4-diClPh	CH2	Single bond	Sub-19
1-564	Sub-50	3，4-diClPh	CH2	Single bond	Sub-20
						1-565	Sub-50	3，4-diClPh	CH2	Single bond	Sub-21
1-566	Sub-50	3，4-diClPh	CH2	Single bond	Sub-22
						1-567	Sub-50	3，4-diClPh	CH2	Single bond	Sub-23
1-568	Sub-50	3，4-diClPh	CH2	Single bond	Sub-24
						1-569	Sub-50	3，4-diClPh	CH2	Single bond	Sub-25
1-570	Sub-50	3，4-diClPh	CH2	Single bond	Sub-26
						1-571	Sub-50	3，4-diClPh	CH2	Single bond	Sub-27
1-572	Sub-50	3，4-diClPh	CH2	Single bond	Sub-28

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-573	Sub-50	3，4-diClPh	CH2	Single bond	Sub-29
1-574	Sub-50	3，4-diClPh	CH2	Single bond	Sub-30
						1-575	Sub-50	3，4-diClPh	CH2	Single bond	Sub-31
1-576	Sub-50	3，4-diClPh	CH2	Single bond	Sub-32
						1-577	Sub-51	3，4-diClPh	CH2	Single bond	Sub-1
1-578	Sub-51	3，4-diClPh	CH2	Single bond	Sub-2
						1-579	Sub-51	3，4-diClPh	CH2	Single bond	Sub-3
1-580	Sub-51	3，4-diClPh	CH2	Single bond	Sub-4
						1-581	Sub-51	3，4-diClPh	CH2	Single bond	Sub-5
1-582	Sub-51	3，4-diClPh	CH2	Single bond	Sub-6
						1-583	Sub-51	3，4-diClPh	CH2	Single bond	Sub-7
1-584	Sub-51	3，4-diClPh	CH2	Single bond	Sub-8
						1-585	Sub-51	3，4-diClPh	CH2	Single bond	Sub-9
1-586	Sub-51	3，4-diClPh	CH2	Single bond	Sub-10
						1-587	Sub-51	3，4-diClPh	CH2	Single bond	Sub-11
1-588	Sub-51	3，4-diClPh	CH2	Single bond	Sub-12
						1-589	Sub-51	3，4-diClPh	CH2	Single bond	Sub-13
1-590	Sub-51	3，4-diClPh	CH2	Single bond	Sub-14
						1-591	Sub-51	3，4-diClPh	CH2	Single bond	Sub-15
1-592	Sub-51	3，4-diClPh	CH2	Single bond	Sub-16
						1-593	Sub-51	3，4-diClPh	CH2	Single bond	Sub-17
1-594	Sub-51	3，4-diClPh	CH2	Single bond	Sub-18
						1-595	Sub-51	3，4-diClPh	CH2	Single bond	Sub-19
1-596	Sub-51	3，4-diClPh	CH2	Single bond	Sub-20
						1-597	Sub-51	3，4-diClPh	CH2	Single bond	Sub-21
1-598	Sub-51	3，4-diClPh	CH2	Single bond	Sub-22

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-599	Sub-51	3，4-diClPh	CH2	Single bond	Sub-23
1-600	Sub-51	3，4-diClPh	CH2	Single bond	Sub-24
						1-601	Sub-51	3，4-diClPh	CH2	Single bond	Sub-25
1-602	Sub-51	3，4-diClPh	CH2	Single bond	Sub-26
						1-603	Sub-51	3，4-diClPh	CH2	Single bond	Sub-27
1-604	Sub-51	3，4-diClPh	CH2	Single bond	Sub-28
						1-605	Sub-51	3，4-diClPh	CH2	Single bond	Sub-29
1-606	Sub-51	3，4-diClPh	CH2	Single bond	Sub-30
						1-607	Sub-51	3，4-diClPh	CH2	Single bond	Sub-31
1-608	Sub-51	3，4-diClPh	CH2	Single bond	Sub-32
						1-609	Sub-52	3，4-diClPh	CH2	Single bond	Sub-1
1-610	Sub-52	3，4-diClPh	CH2	Single bond	Sub-2
						1-611	Sub-52	3，4-diClPh	CH2	Single bond	Sub-3
1-612	Sub-52	3，4-diClPh	CH2	Single bond	Sub-4
						1-613	Sub-52	3，4-diClPh	CH2	Single bond	Sub-5
1-614	Sub-52	3，4-diClPh	CH2	Single bond	Sub-6
						1-615	Sub-52	3，4-diClPh	CH2	Single bond	Sub-7
1-616	Sub-52	3，4-diClPh	CH2	Single bond	Sub-8
						1-617	Sub-52	3，4-diClPh	CH2	Single bond	Sub-9
1-618	Sub-52	3，4-diClPh	CH2	Single bond	Sub-10
						1-619	Sub-52	3，4-diClPh	CH2	Single bond	Sub-11
1-620	Sub-52	3，4-diClPh	CH2	Single bond	Sub-12
						1-621	Sub-52	3，4-diClPh	CH2	Single bond	Sub-13
1-622	Sub-52	3，4-diClPh	CH2	Single bond	Sub-14
						1-623	Sub-52	3，4-diClPh	CH2	Single bond	Sub-15
1-624	Sub-52	3，4-diClPh	CH2	Single bond	Sub-16

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-625	Sub-52	3，4-diClPh	CH2	Single bond	Sub-17
1-626	Sub-52	3，4-diClPh	CH2	Single bond	Sub-18
						1-627	Sub-52	3，4-diClPh	CH2	Single bond	Sub-19
1-628	Sub-52	3，4-diClPh	CH2	Single bond	Sub-20
						1-629	Sub-52	3，4-diClPh	CH2	Single bond	Sub-21
1-630	Sub-52	3，4-diClPh	CH2	Single bond	Sub-22
						1-631	Sub-52	3，4-diClPh	CH2	Single bond	Sub-23
1-632	Sub-52	3，4-diClPh	CH2	Single bond	Sub-24
						1-633	Sub-52	3，4-diClPh	CH2	Single bond	Sub-25
1-634	Sub-52	3，4-diClPh	CH2	Single bond	Sub-26
						1-635	Sub-52	3，4-diClPh	CH2	Single bond	Sub-27
1-636	Sub-52	3，4-diClPh	CH2	Single bond	Sub-28
						1-637	Sub-52	3，4-diClPh	CH2	Single bond	Sub-29
1-638	Sub-52	3，4-diClPh	CH2	Single bond	Sub-30
						1-639	Sub-52	3，4-diClPh	CH2	Single bond	Sub-31
1-640	Sub-52	3，4-diClPh	CH2	Single bond	Sub-32
						1-641	Sub-53	3，4-diClPh	CH2	Single bond	Sub-1
1-642	Sub-53	3，4-diClPh	CH2	Single bond	Sub-2
						1-643	Sub-53	3，4-diClPh	CH2	Single bond	Sub-3
1-644	Sub-53	3，4-diClPh	CH2	Single bond	Sub-4
						1-645	Sub-53	3，4-diClPh	CH2	Single bond	Sub-5
1-646	Sub-53	3，4-diClPh	CH2	Single bond	Sub-6
						1-647	Sub-53	3，4-diClPh	CH2	Single bond	Sub-7
1-648	Sub-53	3，4-diClPh	CH2	Single bond	Sub-8
						1-649	Sub-53	3，4-diClPh	CH2	Single bond	Sub-9
1-650	Sub-53	3，4-diClPh	CH2	Single bond	Sub-10

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-651	Sub-53	3，4-diClPh	CH2	Single bond	Sub-11
1-652	Sub-53	3，4-diClPh	CH2	Single bond	Sub-12
						1-653	Sub-53	3，4-diClPh	CH2	Single bond	Sub-13
1-654	Sub-53	3，4-diClPh	CH2	Single bond	Sub-14
						1-655	Sub-53	3，4-diClPh	CH2	Single bond	Sub-15
1-656	Sub-53	3，4-diClPh	CH2	Single bond	Sub-16
						1-657	Sub-53	3，4-diClPh	CH2	Single bond	Sub-17
1-658	Sub-53	3，4-diClPh	CH2	Single bond	Sub-18
						1-659	Sub-53	3，4-diClPh	CH2	Single bond	Sub-19
1-660	Sub-53	3，4-diClPh	CH2	Single bond	Sub-20
						1-661	Sub-53	3，4-diClPh	CH2	Single bond	Sub-21
1-662	Sub-53	3，4-diClPh	CH2	Single bond	Sub-22
						1-663	Sub-53	3，4-diClPh	CH2	Single bond	Sub-23
1-664	Sub-53	3，4-diClPh	CH2	Single bond	Sub-24
						1-665	Sub-53	3，4-diClPh	CH2	Single bond	Sub-25
1-666	Sub-53	3，4-diClPh	CH2	Single bond	Sub-26
						1-667	Sub-53	3，4-diClPh	CH2	Single bond	Sub-27
1-668	Sub-53	3，4-diClPh	CH2	Single bond	Sub-28
						1-669	Sub-53	3，4-diClPh	CH2	Single bond	Sub-29
1-670	Sub-53	3，4-diClPh	CH2	Single bond	Sub-30
						1-671	Sub-53	3，4-diClPh	CH2	Single bond	Sub-31
1-672	Sub-53	3，4-diClPh	CH2	Single bond	Sub-32
						1-673	Sub-54	3，4-diClPh	CH2	Single bond	Sub-1
1-674	Sub-54	3，4-diClPh	CH2	Single bond	Sub-2
						1-675	Sub-54	3，4-diClPh	CH2	Single bond	Sub-3
1-676	Sub-54	3，4-diClPh	CH2	Single bond	Sub-4

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-677	Sub-54	3，4-diClPh	CH2	Single bond	Sub-5
1-678	Sub-54	3，4-diClPh	CH2	Single bond	Sub-6
						1-679	Sub-54	3，4-diClPh	CH2	Single bond	Sub-7
1-680	Sub-54	3，4-diClPh	CH2	Single bond	Sub-8
						1-681	Sub-54	3，4-diClPh	CH2	Single bond	Sub-9
1-682	Sub-54	3，4-diClPh	CH2	Single bond	Sub-10
						1-683	Sub-54	3，4-diClPh	CH2	Single bond	Sub-11
1-684	Sub-54	3，4-diClPh	CH2	Single bond	Sub-12
						1-685	Sub-54	3，4-diClPh	CH2	Single bond	Sub-13
1-686	Sub-54	3，4-diClPh	CH2	Single bond	Sub-14
						1-687	Sub-54	3，4-diClPh	CH2	Single bond	Sub-15
1-688	Sub-54	3，4-diClPh	CH2	Single bond	Sub-16
						1-689	Sub-54	3，4-diClPh	CH2	Single bond	Sub-17
1-690	Sub-54	3，4-diClPh	CH2	Single bond	Sub-18
						1-691	Sub-54	3，4-diClPh	CH2	Single bond	Sub-19
1-692	Sub-54	3，4-diClPh	CH2	Single bond	Sub-20
						1-693	Sub-54	3，4-diClPh	CH2	Single bond	Sub-21
1-694	Sub-54	3，4-diClPh	CH2	Single bond	Sub-22
						1-695	Sub-54	3，4-diClPh	CH2	Single bond	Sub-23
1-696	Sub-54	3，4-diClPh	CH2	Single bond	Sub-24
						1-697	Sub-54	3，4-diClPh	CH2	Single bond	Sub-25
1-698	Sub-54	3，4-diClPh	CH2	Single bond	Sub-26
						1-699	Sub-54	3，4-diClPh	CH2	Single bond	Sub-27
1-700	Sub-54	3，4-diClPh	CH2	Single bond	Sub-28
						1-701	Sub-54	3，4-diClPh	CH2	Single bond	Sub-29
1-702	Sub-54	3，4-diClPh	CH2	Single bond	Sub-30

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-703	Sub-54	3，4-diClPh	CH2	Single bond	Sub-31
1-704	Sub-54	3，4-diClPh	CH2	Single bond	Sub-32
						1-705	Sub-55	3，4-diClPh	CH2	Single bond	Sub-1
1-706	Sub-55	3，4-diClPh	CH2	Single bond	Sub-2
						1-707	Sub-55	3，4-diClPh	CH2	Single bond	Sub-3
1-708	Sub-55	3，4-diClPh	CH2	Single bond	Sub-4
						1-709	Sub-55	3，4-diClPh	CH2	Single bond	Sub-5
1-710	Sub-55	3，4-diClPh	CH2	Single bond	Sub-6
						1-711	Sub-55	3，4-diClPh	CH2	Single bond	Sub-7
1-712	Sub-55	3，4-diClPh	CH2	Single bond	Sub-8
						1-713	Sub-55	3，4-diClPh	CH2	Single bond	Sub-9
1-714	Sub-55	3，4-diClPh	CH2	Single bond	Sub-10
						1-715	Sub-55	3，4-diClPh	CH2	Single bond	Sub-11
1-716	Sub-55	3，4-diClPh	CH2	Single bond	Sub-12
						1-717	Sub-55	3，4-diClPh	CH2	Single bond	Sub-13
1-718	Sub-55	3，4-diClPh	CH2	Single bond	Sub-14
						1-719	Sub-55	3，4-diClPh	CH2	Single bond	Sub-15
1-720	Sub-55	3，4-diClPh	CH2	Single bond	Sub-16
						1-721	Sub-55	3，4-diClPh	CH2	Single bond	Sub-17
1-722	Sub-55	3，4-diClPh	CH2	Single bond	Sub-18
						1-723	Sub-55	3，4-diClPh	CH2	Single bond	Sub-19
1-724	Sub-55	3，4-diClPh	CH2	Single bond	Sub-20
						1-725	Sub-55	3，4-diClPh	CH2	Single bond	Sub-21
1-726	Sub-55	3，4-diClPh	CH2	Single bond	Sub-22
						1-727	Sub-55	3，4-diClPh	CH2	Single bond	Sub-23
1-728	Sub-55	3，4-diClPh	CH2	Single bond	Sub-24

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-729	Sub-55	3，4-diClPh	CH2	Single bond	Sub-25
1-730	Sub-55	3，4-diClPh	CH2	Single bond	Sub-26
						1-731	Sub-55	3，4-diClPh	CH2	Single bond	Sub-27
1-732	Sub-55	3，4-diClPh	CH2	Single bond	Sub-28
						1-733	Sub-55	3，4-diClPh	CH2	Single bond	Sub-29
1-734	Sub-55	3，4-diClPh	CH2	Single bond	Sub-30
						1-735	Sub-55	3，4-diClPh	CH2	Single bond	Sub-31
1-736	Sub-55	3，4-diClPh	CH2	Single bond	Sub-32
						1-737	Sub-56	3，4-diClPh	CH2	Single bond	Sub-1
1-738	Sub-56	3，4-diClPh	CH2	Single bond	Sub-2
						1-739	Sub-56	3，4-diClPh	CH2	Single bond	Sub-3
1-740	Sub-56	3，4-diClPh	CH2	Single bond	Sub-4
						1-741	Sub-56	3，4-diClPh	CH2	Single bond	Sub-5
1-742	Sub-56	3，4-diClPh	CH2	SheetKey with a key body	Sub-6
						1-743	Sub-56	3，4-diClPh	CH2	Single bond	Sub-7
1-744	Sub-56	3，4-diClPh	CH2	Single bond	Sub-8
						1-745	Sub-56	3，4-diClPh	CH2	Single bond	Sub-9
1-746	Sub-56	3，4-diClPh	CH2	Single bond	Sub-10
						1-747	Sub-56	3，4-diClPh	CH2	Single bond	Sub-11
1-748	Sub-56	3，4-diClPh	CH2	Single bond	Sub-12
						1-749	Sub-56	3，4-diClPh	CH2	Single bond	Sub-13
1-750	Sub-56	3，4-diClPh	CH2	Single bond	Sub-14
						1-751	Sub-56	3，4-diClPh	CH2	Single bond	Sub-15
1-752	Sub-56	3，4-diClPh	CH2	Single bond	Sub-16
						1-753	Sub-56	3，4-diClPh	CH2	Single bond	Sub-17
1-754	Sub-56	3，4-diClPh	CH2	Single bond	Sub-18

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-755	Sub-56	3，4-diClPh	CH2	Single bond	Sub-19
1-756	Sub-56	3，4-diClPh	CH2	Single bond	Sub-20
						1-757	Sub-56	3，4-diClPh	CH2	Single bond	Sub-21
1-758	Sub-56	3，4-diClPh	CH2	Single bond	Sub-22
						1-759	Sub-56	3，4-diClPh	CH2	Single bond	Sub-23
1-760	Sub-56	3，4-diClPh	CH2	Single bond	Sub-24
						1-761	Sub-56	3，4-diClPh	CH2	Single bond	Sub-25
1-762	Sub-56	3，4-diClPh	CH2	Single bond	Sub-26
						1-763	Sub-56	3，4-diClPh	CH2	Single bond	Sub-27
1-764	Sub-56	3，4-diClPh	CH2	Single bond	Sub-28
						1-765	Sub-56	3，4-diClPh	CH2	Single bond	Sub-29
1-766	Sub-56	3，4-diClPh	CH2	Single bond	Sub-30
						1-767	Sub-56	3，4-diClPh	CH2	Single bond	Sub-31
1-768	Sub-56	3，4-diClPh	CH2	Single bond	Sub-32
						1-769	Sub-57	3，4-diClPh	CH2	Single bond	Sub-1
1-770	Sub-57	3，4-diClPh	CH2	Single bond	Sub-2
						1-771	Sub-57	3，4-diClPh	CH2	Single bond	Sub-3
1-772	Sub-57	3，4-diClPh	CH2	Single bond	Sub-4
						1-773	Sub-57	3，4-diClPh	CH2	Single bond	Sub-5
1-774	Sub-57	3，4-diClPh	CH2	Single bond	Sub-6
						1-775	Sub-57	3，4-diClPh	CH2	Single bond	Sub-7
1-776	Sub-57	3，4-diClPh	CH2	Single bond	Sub-8
						1-777	Sub-57	3，4-diClPh	CH2	Single bond	Sub-9
1-778	Sub-57	3，4-diClPh	CH2	Single bond	Sub-10
						1-779	Sub-57	3，4-diClPh	CH2	Single bond	Sub-11
1-780	Sub-57	3，4-diClPh	CH2	Single bond	Sub-12

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-781	Sub-57	3，4-diClPh	CH2	Single bond	Sub-13
1-782	Sub-57	3，4-diClPh	CH2	Single bond	Sub-14
						1-783	Sub-57	3，4-diClPh	CH2	Single bond	Sub-15
1-784	Sub-57	3，4-diClPh	CH2	Single bond	Sub-16
						1-785	Sub-57	3，4-diClPh	CH2	Single bond	Sub-17
1-786	Sub-57	3，4-diClPh	CH2	Single bond	Sub-18
						1-787	Sub-57	3，4-diClPh	CH2	Single bond	Sub-19
1-788	Sub-57	3，4-diClPh	CH2	Single bond	Sub-20
						1-789	Sub-57	3，4-diClPh	CH2	Single bond	Sub-21
1-790	Sub-57	3，4-diClPh	CH2	Single bond	Sub-22
						1-791	Sub-57	3，4-diClPh	CH2	Single bond	Sub-23
1-792	Sub-57	3，4-diClPh	CH2	Single bond	Sub-24
						1-793	Sub-57	3，4-diClPh	CH2	Single bond	Sub-25
1-794	Sub-57	3，4-diClPh	CH2	Single bond	Sub-26
						1-795	Sub-57	3，4-diClPh	CH2	Single bond	Sub-27
1-796	Sub-57	3，4-diClPh	CH2	Single bond	Sub-28
						1-797	Sub-57	3，4-diClPh	CH2	Single bond	Sub-29
1-798	Sub-57	3，4-diClPh	CH2	Single bond	Sub-30
						1-799	Sub-57	3，4-diClPh	CH2	Single bond	Sub-31
1-800	Sub-57	3，4-diClPh	CH2	Single bond	Sub-32
						1-801	Sub-58	3，4-diClPh	CH2	Single bond	Sub-1
1-802	Sub-58	3，4-diClPh	CH2	Single bond	Sub-2
						1-803	Sub-58	3，4-diClPh	CH2	Single bond	Sub-3
1-804	Sub-58	3，4-diClPh	CH2	Single bond	Sub-4
						1-805	Sub-58	3，4-diClPh	CH2	Single bond	Sub-5
1-806	Sub-58	3，4-diClPh	CH2	Single bond	Sub-6

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-807	Sub-58	3，4-diClPh	CH2	Single bond	Sub-7
1-808	Sub-58	3，4-diClPh	CH2	Single bond	Sub-8
						1-809	Sub-58	3，4-diClPh	CH2	Single bond	Sub-9
1-810	Sub-58	3，4-diClPh	CH2	Single bond	Sub-10
						1-811	Sub-58	3，4-diClPh	CH2	Single bond	Sub-11
1-812	Sub-58	3，4-diClPh	CH2	Single bond	Sub-12
						1-813	Sub-58	3，4-diClPh	CH2	Single bond	Sub-13
1-814	Sub-58	3，4-diClPh	CH2	Single bond	Sub-14
						1-815	Sub-58	3，4-diClPh	CH2	Single bond	Sub-15
1-816	Sub-58	3，4-diClPh	CH2	Single bond	Sub-16
						1-817	Sub-58	3，4-diClPh	CH2	Single bond	Sub-17
1-818	Sub-58	3，4-diClPh	CH2	Single bond	Sub-18
						1-819	Sub-58	3，4-diClPh	CH2	Single bond	Sub-19
1-820	Sub-58	3，4-diClPh	CH2	Single bond	Sub-20
						1-821	Sub-58	3，4-diClPh	CH2	Single bond	Sub-21
1-822	Sub-58	3，4-diClPh	CH2	Single bond	Sub-22
						1-823	Sub-58	3，4-diClPh	CH2	Single bond	Sub-23
1-824	Sub-58	3，4-diClPh	CH2	Single bond	Sub-24
						1-825	Sub-58	3，4-diClPh	CH2	Single bond	Sub-25
1-826	Sub-58	3，4-diClPh	CH2	Single bond	Sub-26
						1-827	Sub-58	3，4-diClPh	CH2	Single bond	Sub-27
1-828	Sub-58	3，4-diClPh	CH2	Single bond	Sub-28
						1-829	Sub-58	3，4-diClPh	CH2	Single bond	Sub-29
1-830	Sub-58	3，4-diClPh	CH2	Single bond	Sub-30
						1-831	Sub-58	3，4-diClPh	CH2	Single bond	Sub-31
1-832	Sub-58	3，4-diClPh	CH2	Single bond	Sub-32

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-833	Sub-59	3，4-diClPh	CH2	Single bond	Sub-1
1-834	Sub-59	3，4-diClPh	CH2	Single bond	Sub-2
						1-835	Sub-59	3，4-diClPh	CH2	Single bond	Sub-3
1-836	Sub-59	3，4-diClPh	CH2	Single bond	Sub-4
						1-837	Sub-59	3，4-diClPh	CH2	Single bond	Sub-5
1-838	Sub-59	3，4-diClPh	CH2	Single bond	Sub-6
						1-839	Sub-59	3，4-diClPh	CH2	Single bond	Sub-7
1-840	Sub-59	3，4-diClPh	CH2	Single bond	Sub-8
						1-841	Sub-59	3，4-diClPh	CH2	Single bond	Sub-9
1-842	Sub-59	3，4-diClPh	CH2	Single bond	Sub-10
						1-843	Sub-59	3，4-diClPh	CH2	Single bond	Sub-11
1-844	Sub-59	3，4-diClPh	CH2	Single bond	Sub-12
						1-845	Sub-59	3，4-diClPh	CH2	Single bond	Sub-13
1-846	Sub-59	3，4-diClPh	CH2	Single bond	Sub-14
						1-847	Sub-59	3，4-diClPh	CH2	Single bond	Sub-15
1-848	Sub-59	3，4-diClPh	CH2	Single bond	Sub-16
						1-849	Sub-59	3，4-diClPh	CH2	Single bond	Sub-17
1-850	Sub-59	3，4-diClPh	CH2	Single bond	Sub-18
						1-851	Sub-59	3，4-diClPh	CH2	Single bond	Sub-19
1-852	Sub-59	3，4-diClPh	CH2	Single bond	Sub-20
						1-853	Sub-59	3，4-diClPh	CH2	Single bond	Sub-21
1-854	Sub-59	3，4-diClPh	CH2	Single bond	Sub-22
						1-855	Sub-59	3，4-diClPh	CH2	Single bond	Sub-23
1-856	Sub-59	3，4-diClPh	CH2	Single bond	Sub-24
						1-857	Sub-59	3，4-diClPh	CH2	Single bond	Sub-25
1-858	Sub-59	3，4-diClPh	CH2	Single bond	Sub-26

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-859	Sub-59	3，4-diClPh	CH2	Single bond	Sub-27
1-860	Sub-59	3，4-diClPh	CH2	Single bond	Sub-28
						1-861	Sub-59	3，4-diClPh	CH2	Single bond	Sub-29
1-862	Sub-59	3，4-diClPh	CH2	Single bond	Sub-30
						1-863	Sub-59	3，4-diClPh	CH2	Single bond	Sub-31
1-864	Sub-59	3，4-diClPh	CH2	Single bond	Sub-32
						1-865	Sub-60	3，4-diClPh	CH2	Single bond	Sub-1
1-866	Sub-60	3，4-diClPh	CH2	Single bond	Sub-2
						1-867	Sub-60	3，4-diClPh	CH2	Single bond	Sub-3
1-868	Sub-60	3，4-diClPh	CH2	Single bond	Sub-4
						1-869	Sub-60	3，4-diClPh	CH2	Single bond	Sub-5
1-870	Sub-60	3，4-diClPh	CH2	Single bond	Sub-6
						1-871	Sub-60	3，4-diClPh	CH2	Single bond	Sub-7
1-872	Sub-60	3，4-diClPh	CH2	Single bond	Sub-8
						1-873	Sub-60	3，4-diClPh	CH2	Single bond	Sub-9
1-874	Sub-60	3，4-diClPh	CH2	Single bond	Sub-10
						1-875	Sub-60	3，4-diClPh	CH2	Single bond	Sub-11
1-876	Sub-60	3，4-diClPh	CH2	Single bond	Sub-12
						1-877	Sub-60	3，4-diClPh	CH2	Single bond	Sub-13
1-878	Sub-60	3，4-diClPh	CH2	Single bond	Sub-14
						1-879	Sub-60	3，4-diClPh	CH2	Single bond	Sub-15
1-880	Sub-60	3，4-diClPh	CH2	Single bond	Sub-16
						1-881	Sub-60	3，4-diClPh	CH2	Single bond	Sub-17
1-882	Sub-60	3，4-diClPh	CH2	Single bond	Sub-18
						1-883	Sub-60	3，4-diClPh	CH2	Single bond	Sub-19
1-884	Sub-60	3，4-diClPh	CH2	Single bond	Sub-20

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-885	Sub-60	3，4-diClPh	CH2	Single bond	Sub-21
1-886	Sub-60	3，4-diClPh	CH2	Single bond	Sub-22
						1-887	Sub-60	3，4-diClPh	CH2	Single bond	Sub-23
1-888	Sub-60	3，4-diClPh	CH2	Single bond	Sub-24
						1-889	Sub-60	3，4-diClPh	CH2	Single bond	Sub-25
1-890	Sub-60	3，4-diClPh	CH2	Single bond	Sub-26
						1-891	Sub-60	3，4-diClPh	CH2	Single bond	Sub-27
1-892	Sub-60	3，4-diClPh	CH2	Single bond	Sub-28
						1-893	Sub-60	3，4-diClPh	CH2	Single bond	Sub-29
1-894	Sub-60	3，4-diClPh	CH2	Single bond	Sub-30
						1-895	Sub-60	3，4-diClPh	CH2	Single bond	Sub-31
1-896	Sub-60	3，4-diClPh	CH2	Single bond	Sub-32
						1-897	Sub-61	3，4-diClPh	CH2	Single bond	Sub-1
1-898	Sub-61	3，4-diClPh	CH2	Single bond	Sub-2
						1-899	Sub-61	3，4-diClPh	CH2	Single bond	Sub-3
1-900	Sub-61	3，4-diClPh	CH2	Single bond	Sub-4
						1-901	Sub-61	3，4-diClPh	CH2	Single bond	Sub-5
1-902	Sub-61	3，4-diClPh	CH2	Single bond	Sub-6
						1-903	Sub-61	3，4-diClPh	CH2	Single bond	Sub-7
1-904	Sub-61	3，4-diClPh	CH2	Single bond	Sub-8
						1-905	Sub-61	3，4-diClPh	CH2	Single bond	Sub-9
1-906	Sub-61	3，4-diClPh	CH2	Single bond	Sub-10
						1-907	Sub-61	3，4-diClPh	CH2	Single bond	Sub-11
1-908	Sub-61	3，4-diClPh	CH2	Single bond	Sub-12
						1-909	Sub-61	3，4-diClPh	CH2	Single bond	Sub-13
1-910	Sub-61	3，4-diClPh	CH2	Single bond	Sub-14

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-911	Sub-61	3，4-diClPh	CH2	Single bond	Sub-15
1-912	Sub-61	3，4-diClPh	CH2	Single bond	Sub-16
						1-913	Sub-61	3，4-diClPh	CH2	Single bond	Sub-17
1-914	Sub-61	3，4-diClPh	CH2	Single bond	Sub-18
						1-915	Sub-61	3，4-diClPh	CH2	Single bond	Sub-19
1-916	Sub-61	3，4-diClPh	CH2	Single bond	Sub-20
						1-917	Sub-61	3，4-diClPh	CH2	Single bond	Sub-21
1-918	Sub-61	3，4-diClPh	CH2	Single bond	Sub-22
						1-919	Sub-61	3，4-diClPh	CH2	Single bond	Sub-23
1-920	Sub-61	3，4-diClPh	CH2	Single bond	Sub-24
						1-921	Sub-61	3，4-diClPh	CH2	Single bond	Sub-25
1-922	Sub-61	3，4-diClPh	CH2	Single bond	Sub-26
						1-923	Sub-61	3，4-diClPh	CH2	Single bond	Sub-27
1-924	Sub-61	3，4-diClPh	CH2	Single bond	Sub-28
						1-925	Sub-61	3，4-diClPh	CH2	Single bond	Sub-29
1-926	Sub-61	3，4-diClPh	CH2	Single bond	Sub-30
						1-927	Sub-61	3，4-diClPh	CH2	Single bond	Sub-31
1-928	Sub-61	3，4-diClPh	CH2	Single bond	Sub-32
						1-929	Sub-62	3，4-diClPh	CH2	Single bond	Sub-1
1-930	Sub-62	3，4-diClPh	CH2	Single bond	Sub-2
						1-931	Sub-62	3，4-diClPh	CH2	Single bond	Sub-3
1-932	Sub-62	3，4-diClPh	CH2	Single bond	Sub-4
						1-933	Sub-62	3，4-diClPh	CH2	Single bond	Sub-5
1-934	Sub-62	3，4-diClPh	CH2	Single bond	Sub-6
						1-935	Sub-62	3，4-diClPh	CH2	Single bond	Sub-7
1-936	Sub-62	3，4-diClPh	CH2	Single bond	Sub-8

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-937	Sub-62	3，4-diClPh	CH2	Single bond	Sub-9
1-938	Sub-62	3，4-diClPh	CH2	Single bond	Sub-10
						1-939	Sub-62	3，4-diClPh	CH2	Single bond	Sub-11
1-940	Sub-62	3，4-diClPh	CH2	Single bond	Sub-12
						1-941	Sub-62	3，4-diClPh	CH2	Single bond	Sub-13
1-942	Sub-62	3，4-diClPh	CH2	Single bond	Sub-14
						1-943	Sub-62	3，4-diClPh	CH2	Single bond	Sub-15
1-944	Sub-62	3，4-diClPh	CH2	Single bond	Sub-16
						1-945	Sub-62	3，4-diClPh	CH2	Single bond	Sub-17
1-946	Sub-62	3，4-diClPh	CH2	Single bond	Sub-18
						1-947	Sub-62	3，4-diClPh	CH2	Single bond	Sub-19
1-948	Sub-62	3，4-diClPh	CH2	Single bond	Sub-20
						1-949	Sub-62	3，4-diClPh	CH2	Single bond	Sub-21
1-950	Sub-62	3，4-diClPh	CH2	Single bond	Sub-22
						1-951	Sub-62	3，4-diClPh	CH2	Single bond	Sub-23
1-952	Sub-62	3，4-diClPh	CH2	Single bond	Sub-24
						1-953	Sub-62	3，4-diClPh	CH2	Single bond	Sub-25
1-954	Sub-62	3，4-diClPh	CH2	Single bond	Sub-26
						1-955	Sub-62	3，4-diClPh	CH2	Single bond	Sub-27
1-956	Sub-62	3，4-diClPh	CH2	Single bond	Sub-28
						1-957	Sub-62	3，4-diClPh	CH2	Single bond	Sub-29
1-958	Sub-62	3，4-diClPh	CH2	Single bond	Sub-30
						1-959	Sub-62	3，4-diClPh	CH2	Single bond	Sub-31
1-960	Sub-62	3，4-diClPh	CH2	Single bond	Sub-32
						1-961	Sub-63	3，4-diClPh	CH2	Single bond	Sub-1
1-962	Sub-63	3，4-diClPh	CH2	Single bond	Sub-2

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-963	Sub-63	3，4-diClPh	CH2	Single bond	Sub-3
1-964	Sub-63	3，4-diClPh	CH2	Single bond	Sub-4
						1-965	Sub-63	3，4-diClPh	CH2	Single bond	Sub-5
1-966	Sub-63	3，4-diClPh	CH2	Single bond	Sub-6
						1-967	Sub-63	3，4-diClPh	CH2	Single bond	Sub-7
1-968	Sub-63	3，4-diClPh	CH2	Single bond	Sub-8
						1-969	Sub-63	3，4-diClPh	CH2	Single bond	Sub-9
1-970	Sub-63	3，4-diClPh	CH2	Single bond	Sub-10
						1-971	Sub-63	3，4-diClPh	CH2	Single bond	Sub-11
1-972	Sub-63	3，4-diClPh	CH2	Single bond	Sub-12
						1-973	Sub-63	3，4-diClPh	CH2	Single bond	Sub-13
1-974	Sub-63	3，4-diClPh	CH2	Single bond	Sub-14
						1-975	Sub-63	3，4-diClPh	CH2	Single bond	Sub-15
1-976	Sub-63	3，4-diClPh	CH2	Single bond	Sub-16
						1-977	Sub-63	3，4-diClPh	CH2	Single bond	Sub-17
1-978	Sub-63	3，4-diClPh	CH2	Single bond	Sub-18
						1-979	Sub-63	3，4-diClPh	CH2	Single bond	Sub-19
1-980	Sub-63	3，4-diClPh	CH2	Single bond	Sub-20
						1-981	Sub-63	3，4-diClPh	CH2	Single bond	Sub-21
1-982	Sub-63	3，4-diClPh	CH2	Single bond	Sub-22
						1-983	Sub-63	3，4-diClPh	CH2	Single bond	Sub-23
1-984	Sub-63	3，4-diClPh	CH2	Single bond	Sub-24
						1-985	Sub-63	3，4-diClPh	CH2	Single bond	Sub-25
1-986	Sub-63	3，4-diClPh	CH2	Single bond	Sub-26
						1-987	Sub-63	3，4-diClPh	CH2	Single bond	Sub-27
1-988	Sub-63	3，4-diClPh	CH2	Single bond	Sub-28

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-989	Sub-63	3，4-diClPh	CH2	Single bond	Sub-29
1-990	Sub-63	3，4-diClPh	CH2	Single bond	Sub-30
						1-991	Sub-63	3，4-diClPh	CH2	Single bond	Sub-31
1-992	Sub-63	3，4-diClPh	CH2	Single bond	Sub-32
						1-993	Sub-64	3，4-diClPh	CH2	Single bond	Sub-1
1-994	Sub-64	3，4-diClPh	CH2	Single bond	Sub-2
						1-995	Sub-64	3，4-diClPh	CH2	Single bond	Sub-3
1-996	Sub-64	3，4-diClPh	CH2	Single bond	Sub-4
						1-997	Sub-64	3，4-diClPh	CH2	Single bond	Sub-5
1-998	Sub-64	3，4-diClPh	CH2	Single bond	Sub-6
						1-999	Sub-64	3，4-diClPh	CH2	Single bond	Sub-7
1-1000	Sub-64	3，4-diClPh	CH2	Single bond	Sub-8
						1-1001	Sub-64	3，4-diClPh	CH2	Single bond	Sub-9
1-1002	Sub-64	3，4-diClPh	CH2	Single bond	Sub-10
						1-1003	Sub-64	3，4-diClPh	CH2	Single bond	Sub-11
1-1004	Sub-64	3，4-diClPh	CH2	Single bond	Sub-12
						1-1005	Sub-64	3，4-diClPh	CH2	Single bond	Sub-13
1-1006	Sub-64	3，4-diClPh	CH2	Single bond	Sub-14
						1-1007	Sub-64	3，4-diClPh	CH2	Single bond	Sub-15
1-1008	Sub-64	3，4-diClPh	CH2	Single bond	Sub-16
						1-1009	Sub-64	3，4-diClPh	CH2	Single bond	Sub-17
1-1010	Sub-64	3，4-diClPh	CH2	Single bond	Sub-18
						1-1011	Sub-64	3，4-diClPh	CH2	Single bond	Sub-19
1-1012	Sub-64	3，4-diClPh	CH2	Single bond	Sub-20
						1-1013	Sub-64	3，4-diClPh	CH2	Single bond	Sub-21
1-1014	Sub-64	3，4-diClPh	CH2	Single bond	Sub-22

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1015	Sub-64	3，4-diClPh	CH2	Single bond	Sub-23
1-1016	Sub-64	3，4-diClPh	CH2	Single bond	Sub-24
						1-1017	Sub-64	3，4-diClPh	CH2	Single bond	Sub-25
1-1018	Sub-64	3，4-diClPh	CH2	Single bond	Sub-26
						1-1019	Sub-64	3，4-diClPh	CH2	Single bond	Sub-27
1-1020	Sub-64	3，4-diClPh	CH2	Single bond	Sub-28
						1-1021	Sub-64	3，4-diClPh	CH2	Single bond	Sub-29
1-1022	Sub-64	3，4-diClPh	CH2	Single bond	Sub-30
						1-1023	Sub-64	3，4-diClPh	CH2	Single bond	Sub-31
1-1024	Sub-64	3，4-diClPh	CH2	Single bond	Sub-32
						1-1025	Sub-33	3，4-diClPh	CO	Single bond	Sub-1
1-1026	Sub-33	3，4-diClPh	CO	Single bond	Sub-2
						1-1027	Sub-33	3，4-diClPh	CO	Single bond	Sub-3
1-1028	Sub-33	3，4-diClPh	CO	Single bond	Sub-4
						1-1029	Sub-33	3，4-diClPh	CO	Single bond	Sub-5
1-1030	Sub-33	3，4-diClPh	CO	Single bond	Sub-6
						1-1031	Sub-33	3，4-diClPh	CO	Single bond	Sub-7
1-1032	Sub-33	3，4-diClPh	CO	Single bond	Sub-8
						1-1033	Sub-33	3，4-diClPh	CO	Single bond	Sub-9
1-1034	Sub-33	3，4-diClPh	CO	Single bond	Sub-10
						1-1035	Sub-33	3，4-diClPh	CO	Single bond	Sub-11
1-1036	Sub-33	3，4-diClPh	CO	Single bond	Sub-12
						1-1037	Sub-33	3，4-diClPh	CO	Single bond	Sub-13
1-1038	Sub-33	3，4-diClPh	CO	Single bond	Sub-14
						1-1039	Sub-33	3，4-diClPh	CO	Single bond	Sub-15
1-1040	Sub-33	3，4-diClPh	CO	Single bond	Sub-16

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1041	Sub-33	3，4-diClPh	CO	Single bond	Sub-17
1-1042	Sub-33	3，4-diClPh	CO	Single bond	Sub-18
						1-1043	Sub-33	3，4-diClPh	CO	Single bond	Sub-19
1-1044	Sub-33	3，4-diClPh	CO	Single bond	Sub-20
						1-1045	Sub-33	3，4-diClPh	CO	Single bond	Sub-21
l-1046	Sub-33	3，4-diClPh	CO	Single bond	Sub-22
						1-1047	Sub-33	3，4-diClPh	CO	Single bond	Sub-23
1-1048	Sub-33	3，4-diClPh	CO	Single bond	Sub-24
						1-1049	Sub-33	3，4-diClPh	CO	Single bond	Sub-25
1-1050	Sub-33	3，4-diClPh	CO	Single bond	Sub-26
						1-1051	Sub-33	3，4-diClPh	CO	Single bond	Sub-27
1-1052	Sub-33	3，4-diClPh	CO	Single bond	Sub-28
						1-1053	Sub-33	3，4-diClPh	CO	Single bond	Sub-29
1-1054	Sub-33	3，4-diClPh	CO	Single bond	Sub-30
						1-1055	Sub-33	3，4-diClPh	CO	Single bond	Sub-31
1-1056	Sub-33	3，4-diClPh	CO	Single bond	Sub-32
						1-1057	Sub-34	3，4-diClPh	CO	Single bond	Sub-1
1-1058	Sub-34	3，4-diClPh	CO	Single bond	Sub-2
						1-1059	Sub-34	3，4-diClPh	CO	Single bond	Sub-3
1-1060	Sub-34	3，4-diClPh	CO	Single bond	Sub-4
						1-1061	Sub-34	3，4-diClPh	CO	Single bond	Sub-5
1-1062	Sub-34	3，4-diClPh	CO	Single bond	Sub-6
						1-1063	Sub-34	3，4-diClPh	CO	Single bond	Sub-7
1-1064	Sub-34	3，4-diClPh	CO	Single bond	Sub-8
						1-1065	Sub-34	3，4-diClPh	CO	Single bond	Sub-9
1-1066	Sub-34	3，4-diClPh	CO	Single bond	Sub-10

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1067	Sub-34	3，4-diClPh	CO	Single bond	Sub-11
1-1068	Sub-34	3，4-diClPh	CO	Single bond	Sub-12
						1-1069	Sub-34	3，4-diClPh	CO	Single bond	Sub-13
1-1070	Sub-34	3，4-diClPh	CO	Single bond	Sub-14
						1-1071	Sub-34	3，4-diClPh	CO	Single bond	Sub-15
1-1072	Sub-34	3，4-diClPh	CO	Single bond	Sub-16
						1-1073	Sub-34	3，4-diClPh	CO	Single bond	Sub-17
1-1074	Sub-34	3，4-diClPh	CO	Single bond	Sub-18
						1-1075	Sub-34	3，4-diClPh	CO	Single bond	Sub-19
1-1076	Sub-34	3，4-diClPh	CO	Single bond	Sub-20
						1-1077	Sub-34	3，4-diClPh	CO	Single bond	Sub-21
1-1078	Sub-34	3，4-diClPh	CO	Single bond	Sub-22
						1-1079	Sub-34	3，4-diClPh	CO	Single bond	Sub-23
1-1080	Sub-34	3，4-diClPh	CO	Single bond	Sub-24
						1-1081	Sub-34	3，4-diClPh	CO	Single bond	Sub-25
1-1082	Sub-34	3，4-diClPh	CO	Single bond	Sub-26
						1-1083	Sub-34	3，4-diClPh	CO	Single bond	Sub-27
1-1084	Sub-34	3，4-diClPh	CO	Single bond	Sub-28
						1-1085	Sub-34	3，4-diClPh	CO	Single bond	Sub-29
1-1086	Sub-34	3，4-diClPh	CO	Single bond	Sub-30
						1-1087	Sub-34	3，4-diClPh	CO	Single bond	Sub-31
1-1088	Sub-34	3，4-diClPh	CO	Single bond	Sub-32
						1-1089	Sub-35	3，4-diClPh	CO	Single bond	Sub-1
1-1090	Sub-35	3，4-diClPh	CO	Single bond	Sub-2
						1-1091	Sub-35	3，4-diClPh	CO	Single bond	Sub-3
1-1092	Sub-35	3，4-diClPh	CO	Single bond	Sub-4

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1093	Sub-35	3，4-diClPh	CO	Single bond	Sub-5
1-1094	Sub-35	3，4-diClPh	CO	Single bond	Sub-6
						1-1095	Sub-35	3，4-diClPh	CO	Single bond	Sub-7
1-1096	Sub-35	3，4-diClPh	CO	Single bond	Sub-8
						1-1097	Sub-35	3，4-diClPh	CO	Single bond	Sub-9
1-1098	Sub-35	3，4-diClPh	CO	Single bond	Sub-10
						1-1099	Sub-35	3，4-diClPh	CO	Single bond	Sub-11
1-1100	Sub-35	3，4-diClPh	CO	Single bond	Sub-12
						1-1101	Sub-35	3，4-diClPh	CO	Single bond	Sub-13
1-1102	Sub-35	3，4-diClPh	CO	Single bond	Sub-14
						1-1103	Sub-35	3，4-diClPh	CO	Single bond	Sub-15
1-1104	Sub-35	3，4-diClPh	CO	Single bond	Sub-16
						1-1105	Sub-35	3，4-diClPh	CO	Single bond	Sub-17
1-1106	Sub-35	3，4-diClPh	CO	Single bond	Sub-18
						1-1107	Sub-35	3，4-diClPh	CO	Single bond	Sub-19
1-1108	Sub-35	3，4-diClPh	CO	Single bond	Sub-20
						1-1109	Sub-35	3，4-diClPh	CO	Single bond	Sub-21
1-1110	Sub-35	3，4-diClPh	CO	Single bond	Sub-22
						1-1111	Sub-35	3，4-diClPh	CO	Single bond	Sub-23
1-1112	Sub-35	3，4-diClPh	CO	Single bond	Sub-24
						1-1113	Sub-35	3，4-diClPh	CO	Single bond	Sub-25
1-1114	Sub-35	3，4-diClPh	CO	Single bond	Sub-26
						1-1115	Sub-35	3，4-diClPh	CO	Single bond	Sub-27
1-1116	Sub-35	3，4-diClPh	CO	Single bond	Sub-28
						1-1117	Sub-35	3，4-diClPh	CO	Single bond	Sub-29
1-1118	Sub-35	3，4-diClPh	CO	Single bond	Sub-30

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1119	Sub-35	3，4-diClPh	CO	Single bond	Sub-31
1-1120	Sub-35	3，4-diClPh	CO	Single bond	Sub-32
						1-1121	Sub-36	3，4-diClPh	CO	Single bond	Sub-1
1-1122	Sub-36	3，4-diClPh	CO	Single bond	Sub-2
						1-1123	Sub-36	3，4-diClPh	CO	Single bond	Sub-3
1-1124	Sub-36	3，4-diClPh	CO	Single bond	Sub-4
						1-1125	Sub-36	3，4-diClPh	CO	Single bond	Sub-5
1-1126	Sub-36	3，4-diClPh	CO	Single bond	Sub-6
						1-1127	Sub-36	3，4-diClPh	CO	Single bond	Sub-7
1-1128	Sub-36	3，4-diClPh	CO	Single bond	Sub-8
						1-1129	Sub-36	3，4-diClPh	CO	Single bond	Sub-9
1-1130	Sub-36	3，4-diClPh	CO	Single bond	Sub-10
						1-1131	Sub-36	3，4-diClPh	CO	Single bond	Sub-11
1-1132	Sub-36	3，4-diClPh	CO	Single bond	Sub-12
						1-1133	Sub-36	3，4-diClPh	CO	Single bond	Sub-13
1-1134	Sub-36	3，4-diClPh	CO	Single bond	Sub-14
						1-1135	Sub-36	3，4-diClPh	CO	Single bond	Sub-15
1-1136	Sub-36	3，4-diClPh	CO	Single bond	Sub-16
						1-1137	Sub-36	3，4-diClPh	CO	Single bond	Sub-17
1-1138	Sub-36	3，4-diClPh	CO	Single bond	Sub-18
						1-1139	Sub-36	3，4-diClPh	CO	Single bond	Sub-19
1-1140	Sub-36	3，4-diClPh	CO	Single bond	Sub-20
						1-1141	Sub-36	3，4-diClPh	CO	Single bond	Sub-21
1-1142	Sub-36	3，4-diClPh	CO	Single bond	Sub-22
						1-1143	Sub-36	3，4-diClPh	CO	Single bond	Sub-23
1-1144	Sub-36	3，4-diClPh	CO	Single bond	Sub-24

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1145	Sub-36	3，4-diClPh	CO	Single bond	Sub-25
1-1146	Sub-36	3，4-diClPh	CO	Single bond	Sub-26
						1-1147	Sub-36	3，4-diClPh	CO	Single bond	Sub-27
1-1148	Sub-36	3，4-diClPh	CO	Single bond	Sub-28
						1-1149	Sub-36	3，4-diClPh	CO	Single bond	Sub-29
1-1150	Sub-36	3，4-diClPh	CO	Single bond	Sub-30
						1-1151	Sub-36	3，4-diClPh	CO	Single bond	Sub-31
1-1152	Sub-36	3，4-diClPh	CO	Single bond	Sub-32
						1-1153	Sub-37	3，4-diClPh	CO	Single bond	Sub-1
1-1154	Sub-37	3，4-diClPh	CO	Single bond	Sub-2
						1-1155	Sub-37	3，4-diClPh	CO	Single bond	Sub-3
1-1156	Sub-37	3，4-diClPh	CO	Single bond	Sub-4
						1-1157	Sub-37	3，4-diClPh	CO	Single bond	Sub-5
1-1158	Sub-37	3，4-diClPh	CO	Single bond	Sub-6
						1-1159	Sub-37	3，4-diClPh	CO	Single bond	Sub-7
1-1160	Sub-37	3，4-diClPh	CO	Single bond	Sub-8
						1-1161	Sub-37	3，4-diClPh	CO	Single bond	Sub-9
1-1162	Sub-37	3，4-diClPh	CO	Single bond	Sub-10
						1-1163	Sub-37	3，4-diClPh	CO	Single bond	Sub-11
1-1164	Sub-37	3，4-diClPh	CO	Single bond	Sub-12
						1-1165	Sub-37	3，4-diClPh	CO	Single bond	Sub-13
1-1166	Sub-37	3，4-diClPh	CO	Single bond	Sub-14
						1-1167	Sub-37	3，4-diClPh	CO	Single bond	Sub-15
1-1168	Sub-37	3，4-diClPh	CO	Single bond	Sub-16
						1-1169	Sub-37	3，4-diClPh	CO	Single bond	Sub-17
1-1170	Sub-37	3，4-diClPh	CO	Single bond	Sub-18

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1171	Sub-37	3，4-diClPh	CO	Single bond	Sub-19
1-1172	Sub-37	3，4-diClPh	CO	Single bond	Sub-20
						1-1173	Sub-37	3，4-diClPh	CO	Single bond	Sub-21
1-1174	Sub-37	3，4-diClPh	CO	Single bond	Sub-22
						1-1175	Sub-37	3，4-diClPh	CO	Single bond	Sub-23
1-1176	Sub-37	3，4-diClPh	CO	Single bond	Sub-24
						1-1177	Sub-37	3，4-diClPh	CO	Single bond	Sub-25
1-1178	Sub-37	3，4-diClPh	CO	Single bond	Sub-26
						1-1179	Sub-37	3，4-diClPh	CO	Single bond	Sub-27
1-1180	Sub-37	3，4-diClPh	CO	Single bond	Sub-28
						1-1181	Sub-37	3，4-diClPh	CO	Single bond	Sub-29
1-1182	Sub-37	3，4-diClPh	CO	Single bond	Sub-30
						1-1183	Sub-37	3，4-diClPh	CO	Single bond	Sub-31
1-1184	Sub-37	3，4-diClPh	CO	Single bond	Sub-32
						1-1185	Sub-38	3，4-diClPh	CO	Single bond	Sub-1
1-1186	Sub-38	3，4-diClPh	CO	Single bond	Sub-2
						1-1187	Sub-38	3，4-diClPh	CO	Single bond	Sub-3
1-1188	Sub-38	3，4-diClPh	CO	Single bond	Sub-4
						1-1189	Sub-38	3，4-diClPh	CO	Single bond	Sub-5
1-1190	Sub-38	3，4-diClPh	CO	Single bond	Sub-6
						1-1191	Sub-38	3，4-diClPh	CO	Single bond	Sub-7
1-1192	Sub-38	3，4-diClPh	CO	Single bond	Sub-8
						1-1193	Sub-38	3，4-diClPh	CO	Single bond	Sub-9
1-1194	Sub-38	3，4-diClPh	CO	Single bond	Sub-10
						1-1195	Sub-38	3，4-diClPh	CO	Single bond	Sub-11
1-1196	Sub-38	3，4-diClPh	CO	Single bond	Sub-12

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1197	Sub-38	3，4-diClPh	CO	Single bond	Sub-13
1-1198	Sub-38	3，4-diClPh	CO	Single bond	Sub-14
						1-1199	Sub-38	3，4-diClPh	CO	Single bond	Sub-15
1-1200	Sub-38	3，4-diClPh	CO	Single bond	Sub-16
						1-1201	Sub-38	3，4-diClPh	CO	Single bond	Sub-17
1-1202	Sub-38	3，4-diClPh	CO	Single bond	Sub-18
						1-1203	Sub-38	3，4-diClPh	CO	Single bond	Sub-19
1-1204	Sub-38	3，4-diClPh	CO	Single bond	Sub-20
						1-1205	Sub-38	3，4-diClPh	CO	Single bond	Sub-21
1-1206	Sub-38	3，4-diClPh	CO	Single bond	Sub-22
						1-1207	Sub-38	3，4-diClPh	CO	Single bond	Sub-23
1-1208	Sub-38	3，4-diClPh	CO	Single bond	Sub-24
						1-1209	Sub-38	3，4-diClPh	CO	Single bond	Sub-25
1-1210	Sub-38	3，4-diClPh	CO	Single bond	Sub-26
						1-1211	Sub-38	3，4-diClPh	CO	Single bond	Sub-27
1-1212	Sub-38	3，4-diClPh	CO	Single bond	Sub-28
						1-1213	Sub-38	3，4-diClPh	CO	Single bond	Sub-29
1-1214	Sub-38	3，4-diClPh	CO	Single bond	Sub-30
						1-1215	Sub-38	3，4-diClPh	CO	Single bond	Sub-31
1-1216	Sub-38	3，4-diClPh	CO	Single bond	Sub-32
						1-1217	Sub-39	3，4-diClPh	CO	Single bond	Sub-1
1-1218	Sub-39	3，4-diClPh	CO	Single bond	Sub-2
						1-1219	Sub-39	3，4-diClPh	CO	Single bond	Sub-3
1-1220	Sub-39	3，4-diClPh	CO	Single bond	Sub-4
						1-1221	Sub-39	3，4-diClPh	CO	Single bond	Sub-5
1-1222	Sub-39	3，4-diClPh	CO	Single bond	Sub-6

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1223	Sub-39	3，4-diClPh	CO	Single bond	Sub-7
1-1224	Sub-39	3，4-diClPh	CO	Single bond	Sub-8
						1-1225	Sub-39	3，4-diClPh	CO	Single bond	Sub-9
1-1226	Sub-39	3，4-diClPh	CO	Single bond	Sub-10
						1-1227	Sub-39	3，4-diClPh	CO	Single bond	Sub-11
1-1228	Sub-39	3，4-diClPh	CO	Single bond	Sub-12
						1-1229	Sub-39	3，4-diClPh	CO	Single bond	Sub-13
1-1230	Sub-39	3，4-diClPh	CO	Single bond	Sub-14
						1-1231	Sub-39	3，4-diClPh	CO	Single bond	Sub-15
1-1232	Sub-39	3，4-diClPh	CO	Single bond	Sub-16
						1-1233	Sub-39	3，4-diClPh	CO	Single bond	Sub-17
1-1234	Sub-39	3，4-diClPh	CO	Single bond	Sub-18
						1-1235	Sub-39	3，4-diClPh	CO	Single bond	Sub-19
1-1236	Sub-39	3，4-diClPh	CO	Single bond	Sub-20
						1-1237	Sub-39	3，4-diClPh	CO	Single bond	Sub-21
1-1238	Sub-39	3，4-diClPh	CO	Single bond	Sub-22
						1-1239	Sub-39	3，4-diClPh	CO	Single bond	Sub-23
1-1240	Sub-39	3，4-diClPh	CO	Single bond	Sub-24
						1-1241	Sub-39	3，4-diClPh	CO	Single bond	Sub-25
1-1242	Sub-39	3，4-diClPh	CO	Single bond	Sub-26
						1-1243	Sub-39	3，4-diClPh	CO	Single bond	Sub-27
1-1244	Sub-39	3，4-diClPh	CO	Single bond	Sub-28
						1-1245	Sub-39	3，4-diClPh	CO	Single bond	Sub-29
1-1246	Sub-39	3，4-diClPh	CO	Single bond	Sub-30
						1-1247	Sub-39	3，4-diClPh	CO	Single bond	Sub-31
1-1248	Sub-39	3，4-diClPh	CO	Single bond	Sub-32

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1249	Sub-40	3，4-diClPh	CO	Single bond	Sub-1
1-1250	Sub-40	3，4-diClPh	CO	Single bond	Sub-2
						1-1251	Sub-40	3，4-diClPh	CO	Single bond	Sub-3
1-1252	Sub-40	3，4-diClPh	CO	Single bond	Sub-4
						1-1253	Sub-40	3，4-diClPh	CO	Single bond	Sub-5
1-1254	Sub-40	3，4-diClPh	CO	Single bond	Sub-6
						1-1255	Sub-40	3，4-diClPh	CO	Single bond	Sub-7
1-1256	Sub-40	3，4-diClPh	CO	Single bond	Sub-8
						1-1257	Sub-40	3，4-diClPh	CO	Single bond	Sub-9
1-1258	Sub-40	3，4-diClPh	CO	Single bond	Sub-10
						1-1259	Sub-40	3，4-diClPh	CO	Single bond	Sub-11
1-1260	Sub-40	3，4-diClPh	CO	Single bond	Sub-12
						1-1261	Sub-40	3，4-diClPh	CO	Single bond	Sub-13
1-1262	Sub-40	3，4-diClPh	CO	Single bond	Sub-14
						1-1263	Sub-40	3，4-diClPh	CO	Single bond	Sub-15
1-1264	Sub-40	3，4-diClPh	CO	Single bond	Sub-16
						1-1265	Sub-40	3，4-diClPh	CO	Single bond	Sub-17
1-1266	Sub-40	3，4-diClPh	CO	Single bond	Sub-18
						1-1267	Sub-40	3，4-diClPh	CO	Single bond	Sub-19
1-1268	Sub-40	3，4-diClPh	CO	Single bond	Sub-20
						1-1269	Sub-40	3，4-diClPh	CO	Single bond	Sub-21
1-1270	Sub-40	3，4-diClPh	CO	Single bond	Sub-22
						1-1271	Sub-40	3，4-diClPh	CO	Single bond	Sub-23
1-1272	Sub-40	3，4-diClPh	CO	Single bond	Sub-24
						1-1273	Sub-40	3，4-diClPh	CO	Single bond	Sub-25
1-1274	Sub-40	3，4-diClPh	CO	Single bond	Sub-26

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1275	Sub-40	3，4-diClPh	CO	Single bond	Sub-27
1-1276	Sub-40	3，4-diClPh	CO	Single bond	Sub-28
						1-1277	Sub-40	3，4-diClPh	CO	Single bond	Sub-29
1-1278	Sub-40	3，4-diClPh	CO	Single bond	Sub-30
						1-1279	Sub-40	3，4-diClPh	CO	Single bond	Sub-31
1-1280	Sub-40	3，4-diClPh	CO	Single bond	Sub-32
						1-1281	Sub-41	3，4-diClPh	CO	Single bond	Sub-1
1-1282	Sub-41	3，4-diClPh	CO	Single bond	Sub-2
						1-1283	Sub-41	3，4-diClPh	CO	Single bond	Sub-3
1-1284	Sub-41	3，4-diClPh	CO	Single bond	Sub-4
						1-1285	Sub-41	3，4-diClPh	CO	Single bond	Sub-5
1-1286	Sub-41	3，4-diClPh	CO	Single bond	Sub-6
						1-1287	Sub-41	3，4-diClPh	CO	Single bond	Sub-7
1-1288	Sub-41	3，4-diClPh	CO	Single bond	Sub-8
						1-1289	Sub-41	3，4-diClPh	CO	Single bond	Sub-9
1-1290	Sub-41	3，4-diClPh	CO	Single bond	Sub-10
						1-1291	Sub-41	3，4-diClPh	CO	Single bond	Sub-11
1-1292	Sub-41	3，4-diClPh	CO	Single bond	Sub-12
						1-1293	Sub-41	3，4-diClPh	CO	Single bond	Sub-13
1-1294	Sub-41	3，4-diClPh	CO	Single bond	Sub-14
						1-1295	Sub-41	3，4-diClPh	CO	Single bond	Sub-15
1-1296	Sub-41	3，4-diClPh	CO	Single bond	Sub-16
						1-1297	Sub-41	3，4-diClPh	CO	Single bond	Sub-17
1-1298	Sub-41	3，4-diClPh	CO	Single bond	Sub-18
						1-1299	Sub-41	3，4-diClPh	CO	Single bond	Sub-19
1-1300	Sub-41	3，4-diClPh	CO	Single bond	Sub-20

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1301	Sub-41	3，4-diClPh	CO	Single bond	Sub-21
1-1302	Sub-41	3，4-diClPh	CO	Single bond	Sub-22
						1-1303	Sub-41	3，4-diClPh	CO	Single bond	Sub-23
1-1304	Sub-41	3，4-diClPh	CO	Single bond	Sub-24
						1-1305	Sub-41	3，4-diClPh	CO	Single bond	Sub-25
1-1306	Sub-41	3，4-diClPh	CO	Single bond	Sub-26
						1-1307	Sub-41	3，4-diClPh	CO	Single bond	Sub-27
1-1308	Sub-41	3，4-diClPh	CO	Single bond	Sub-28
						1-1309	Sub-41	3，4-diClPh	CO	Single bond	Sub-29
1-1310	Sub-41	3，4-diClPh	CO	Single bond	Sub-30
						1-1311	Sub-41	3，4-diClPh	CO	Single bond	Sub-31
1-1312	Sub-41	3，4-diClPh	CO	Single bond	Sub-32
						1-1313	Sub-42	3，4-diClPh	CO	Single bond	Sub-1
1-1314	Sub-42	3，4-diClPh	CO	Single bond	Sub-2
						1-1315	Sub-42	3，4-diClPh	CO	Single bond	Sub-3
1-1316	Sub-42	3，4-diClPh	CO	Single bond	Sub-4
						1-1317	Sub-42	3，4-diClPh	CO	Single bond	Sub-5
1-1318	Sub-42	3，4-diClPh	CO	Single bond	Sub-6
						1-1319	Sub-42	3，4-diClPh	CO	Single bond	Sub-7
1-1320	Sub-42	3，4-diClPh	CO	Single bond	Sub-8
						1-1321	Sub-42	3，4-diClPh	CO	Single bond	Sub-9
1-1322	Sub-42	3，4-diClPh	CO	Single bond	Sub-10
						1-1323	Sub-42	3，4-diClPh	CO	Single bond	Sub-11
1-1324	Sub-42	3，4-diClPh	CO	Single bond	Sub-12
						1-1325	Sub-42	3，4-diClPh	CO	Single bond	Sub-13
1-1326	Sub-42	3，4-diClPh	CO	Single bond	Sub-14

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1327	Sub-42	3，4-diClPh	CO	Single bond	Sub-15
1-1328	Sub-42	3，4-diClPh	CO	Single bond	Sub-16
						1-1329	Sub-42	3，4-diClPh	CO	Single bond	Sub-17
1-1330	Sub-42	3，4-diClPh	CO	Single bond	Sub-18
						1-1331	Sub-42	3，4-diClPh	CO	Single bond	Sub-19
1-1332	Sub-42	3，4-diClPh	CO	Single bond	Sub-20
						1-1333	Sub-42	3，4-diClPh	CO	Single bond	Sub-21
1-1334	Sub-42	3，4-diClPh	CO	Single bond	Sub-22
						1-1335	Sub-42	3，4-diClPh	CO	Single bond	Sub-23
1-1336	Sub-42	3，4-diClPh	CO	Single bond	Sub-24
						1-1337	Sub-42	3，4-diClPh	CO	Single bond	Sub-25
1-1338	Sub-42	3，4-diClPh	CO	Single bond	Sub-26
						1-1339	Sub-42	3，4-diClPh	CO	Single bond	Sub-27
1-1340	Sub-42	3，4-diClPh	CO	Single bond	Sub-28
						1-1341	Sub-42	3，4-diClPh	CO	Single bond	Sub-29
1-1342	Sub-42	3，4-diClPh	CO	Single bond	Sub-30
						1-1343	Sub-42	3，4-diClPh	CO	Single bond	Sub-31
1-1344	Sub-42	3，4-diClPh	CO	Single bond	Sub-32
						1-1345	Sub-43	3，4-diClPh	CO	Single bond	Sub-1
1-1346	Sub-43	3，4-diClPh	CO	Single bond	Sub-2
						1-1347	Sub-43	3，4-diClPh	CO	Single bond	Sub-3
1-1348	Sub-43	3，4-diClPh	CO	Single bond	Sub-4
						1-1349	Sub-43	3，4-diClPh	CO	Single bond	Sub-5
1-1350	Sub-43	3，4-diClPh	CO	Single bond	Sub-6
						1-1351	Sub-43	3，4-diClPh	CO	Single bond	Sub-7
1-1352	Sub-43	3，4-diClPh	CO	Single bond	Sub-8

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1353	Sub-43	3，4-diClPh	CO	Single bond	Sub-9
1-1354	Sub-43	3，4-diClPh	CO	Single bond	Sub-10
						1-1355	Sub-43	3，4-diClPh	CO	Single bond	Sub-11
1-1356	Sub-43	3，4-diClPh	CO	Single bond	Sub-12
						1-1357	Sub-43	3，4-diClPh	CO	Single bond	Sub-13
1-1358	Sub-43	3，4-diClPh	CO	Single bond	Sub-14
						1-1359	Sub-43	3，4-diClPh	CO	Single bond	Sub-15
1-1360	Sub-43	3，4-diClPh	CO	Single bond	Sub-16
						1-1361	Sub-43	3，4-diClPh	CO	Single bond	Sub-17
1-1362	Sub-43	3，4-diClPh	CO	Single bond	Sub-18
						1-1363	Sub-43	3，4-diClPh	CO	Single bond	Sub-19
1-1364	Sub-43	3，4-diClPh	CO	Single bond	Sub-20
						1-1365	Sub-43	3，4-diClPh	CO	Single bond	Sub-21
1-1366	Sub-43	3，4-diClPh	CO	Single bond	Sub-22
						1-1367	Sub-43	3，4-diClPh	CO	Single bond	Sub-23
1-1368	Sub-43	3，4-diClPh	CO	Single bond	Sub-24
						1-1369	Sub-43	3，4-diClPh	CO	Single bond	Sub-25
1-1370	Sub-43	3，4-diClPh	CO	Single bond	Sub-26
						1-1371	Sub-43	3，4-diClPh	CO	Single bond	Sub-27
1-1372	Sub-43	3，4-diClPh	CO	Single bond	Sub-28
						1-1373	Sub-43	3，4-diClPh	CO	Single bond	Sub-29
1-1374	Sub-43	3，4-diClPh	CO	Single bond	Sub-30
						1-1375	Sub-43	3，4-diClPh	CO	Single bond	Sub-31
1-1376	Sub-43	3，4-diClPh	CO	Single bond	Sub-32
						1-1377	Sub-44	3，4-diClPh	CO	Single bond	Sub-1
1-1378	Sub-44	3，4-diClPh	CO	Single bond	Sub-2

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1379	Sub-44	3，4-diClPh	CO	Single bond	Sub-3
1-1380	Sub-44	3，4-diClPh	CO	Single bond	Sub-4
						1-1381	Sub-44	3，4-diClPh	CO	Single bond	Sub-5
1-1382	Sub-44	3，4-diClPh	CO	Single bond	Sub-6
						1-1383	Sub-44	3，4-diClPh	CO	Single bond	Sub-7
1-1384	Sub-44	3，4-diClPh	CO	Single bond	Sub-8
						1-1385	Sub-44	3，4-diClPh	CO	Single bond	Sub-9
1-1386	Sub-44	3，4-diClPh	CO	Single bond	Sub-10
						1-1387	Sub-44	3，4-diClPh	CO	Single bond	Sub-11
1-1388	Sub-44	3，4-diClPh	CO	Single bond	Sub-12
						1-1389	Sub-44	3，4-diClPh	CO	Single bond	Sub-13
1-1390	Sub-44	3，4-diClPh	CO	Single bond	Sub-14
						1-1391	Sub-44	3，4-diClPh	CO	Single bond	Sub-15
1-1392	Sub-44	3，4-diClPh	CO	Single bond	Sub-16
						1-1393	Sub-44	3，4-diClPh	CO	Single bond	Sub-17
1-1394	Sub-44	3，4-diClPh	CO	Single bond	Sub-18
						1-1395	Sub-44	3，4-diClPh	CO	Single bond	Sub-19
1-1396	Sub-44	3，4-diClPh	CO	Single bond	Sub-20
						1-1397	Sub-44	3，4-diClPh	CO	Single bond	Sub-21
1-1398	Sub-44	3，4-diClPh	CO	Single bond	Sub-22
						1-1399	Sub-44	3，4-diClPh	CO	Single bond	Sub-23
1-1400	Sub-44	3，4-diClPh	CO	Single bond	Sub-24
						1-1401	Sub-44	3，4-diClPh	CO	Single bond	Sub-25
1-1402	Sub-44	3，4-diClPh	CO	Single bond	Sub-26
						1-1403	Sub-44	3，4-diClPh	CO	Single bond	Sub-27
1-1404	Sub-44	3，4-diClPh	CO	Single bond	Sub-28

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1405	Sub-44	3，4-diClPh	CO	Single bond	Sub-29
1-1406	Sub-44	3，4-diClPh	CO	Single bond	Sub-30
						1-1407	Sub-44	3，4-diClPh	CO	Single bond	Sub-31
1-1408	Sub-44	3，4-diClPh	CO	Single bond	Sub-32
						1-1409	Sub-45	3，4-diClPh	CO	Single bond	Sub-1
1-1410	Sub-45	3，4-diClPh	CO	Single bond	Sub-2
						1-1411	Sub-45	3，4-diClPh	CO	Single bond	Sub-3
1-1412	Sub-45	3，4-diClPh	CO	Single bond	Sub-4
						1-1413	Sub-45	3，4-diClPh	CO	Single bond	Sub-5
1-1414	Sub-45	3，4-diClPh	CO	Single bond	Sub-6
						1-1415	Sub-45	3，4-diClPh	CO	Single bond	Sub-7
1-1416	Sub-45	3，4-diClPh	CO	Single bond	Sub-8
						1-1417	Sub-45	3，4-diClPh	CO	Single bond	Sub-9
1-1418	Sub-45	3，4-diClPh	CO	Single bond	Sub-10
						1-1419	Sub-45	3，4-diClPh	CO	Single bond	Sub-11
1-1420	Sub-45	3，4-diClPh	CO	Single bond	Sub-12
						1-1421	Sub-45	3，4-diClPh	CO	Single bond	Sub-13
1-1422	Sub-45	3，4-diClPh	CO	Single bond	Sub-14
						1-1423	Sub-45	3，4-diClPh	CO	Single bond	Sub-15
1-1424	Sub-45	3，4-diClPh	CO	Single bond	Sub-16
						1-1425	Sub-45	3，4-diClPh	CO	Single bond	Sub-17
1-1426	Sub-45	3，4-diClPh	CO	Single bond	Sub-18
						1-1427	Sub-45	3，4-diClPh	CO	Single bond	Sub-19
1-1428	Sub-45	3，4-diClPh	CO	Single bond	Sub-20
						1-1429	Sub-45	3，4-diClPh	CO	Single bond	Sub-21
1-1430	Sub-45	3，4-diClPh	CO	Single bond	Sub-22

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1431	Sub-45	3，4-diClPh	CO	Single bond	Sub-23
1-1432	Sub-45	3，4-diClPh	CO	Single bond	Sub-24
						1-1433	Sub-45	3，4-diClPh	CO	Single bond	Sub-25
1-1434	Sub-45	3，4-diClPh	CO	Single bond	Sub-26
						1-1435	Sub-45	3，4-diClPh	CO	Single bond	Sub-27
1-1436	Sub-45	3，4-diClPh	CO	Single bond	Sub-28
						1-1437	Sub-45	3，4-diClPh	CO	Single bond	Sub-29
1-1438	Sub-45	3，4-diClPh	CO	Single bond	Sub-30
						1-1439	Sub-45	3，4-diClPh	CO	Single bond	Sub-31
1-1440	Sub-45	3，4-diClPh	CO	Single bond	Sub-32
						1-1441	Sub-46	3，4-diClPh	CO	Single bond	Sub-1
1-1442	Sub-46	3，4-diClPh	CO	Single bond	Sub-2
						1-1443	Sub-46	3，4-diClPh	CO	Single bond	Sub-3
1-1444	Sub-46	3，4-diClPh	CO	Single bond	Sub-4
						1-1445	Sub-46	3，4-diClPh	CO	Single bond	Sub-5
1-1446	Sub-46	3，4-diClPh	CO	Single bond	Sub-6
						1-1447	Sub-46	3，4-diClPh	CO	Single bond	Sub-7
1-1448	Sub-46	3，4-diClPh	CO	Single bond	Sub-8
						1-1449	Sub-46	3，4-diClPh	CO	Single bond	Sub-9
1-1450	Sub-46	3，4-diClPh	CO	Single bond	Sub-10
						1-1451	Sub-46	3，4-diClPh	CO	Single bond	Sub-11
1-1452	Sub-46	3，4-diClPh	CO	Single bond	Sub-12
						1-1453	Sub-46	3，4-diClPh	CO	Single bond	Sub-13
1-1454	Sub-46	3，4-diClPh	CO	Single bond	Sub-14
						1-1455	Sub-46	3，4-diClPh	CO	Single bond	Sub-15
1-1456	Sub-46	3，4-diClPh	CO	Single bond	Sub-16

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1457	Sub-46	3，4-diClPh	CO	Single bond	Sub-17
1-1458	Sub-46	3，4-diClPh	CO	Single bond	Sub-18
						1-1459	Sub-46	3，4-diClPh	CO	Single bond	Sub-19
1-1460	Sub-46	3，4-diClPh	CO	Single bond	Sub-20
						1-1461	Sub-46	3，4-diClPh	CO	Single bond	Sub-21
1-1462	Sub-46	3，4-diClPh	CO	Single bond	Sub-22
						1-1463	Sub-46	3，4-diClPh	CO	Single bond	Sub-23
1-1464	Sub-46	3，4-diClPh	CO	Single bond	Sub-24
						1-1465	Sub-46	3，4-diClPh	CO	Single bond	Sub-25
1-1466	Sub-46	3，4-diClPh	CO	Single bond	Sub-26
						1-1467	Sub-46	3，4-diClPh	CO	Single bond	Sub-27
1-1468	Sub-46	3，4-diClPh	CO	Single bond	Sub-28
						1-1469	Sub-46	3，4-diClPh	CO	Single bond	Sub-29
1-1470	Sub-46	3，4-diClPh	CO	Single bond	Sub-30
						1-1471	Sub-46	3，4-diClPh	CO	Single bond	Sub-31
1-1472	Sub-46	3，4-diClPh	CO	Single bond	Sub-32
						1-1473	Sub-47	3，4-diClPh	CO	Single bond	Sub-1
1-1474	Sub-47	3，4-diClPh	CO	Single bond	Sub-2
						1-1475	Sub-47	3，4-diClPh	CO	Single bond	Sub-3
1-1476	Sub-47	3，4-diClPh	CO	Single bond	Sub-4
						1-1477	Sub-47	3，4-diClPh	CO	Single bond	Sub-5
1-1478	Sub-47	3，4-diClPh	CO	Single bond	Sub-6
						1-1479	Sub-47	3，4-diClPh	CO	Single bond	Sub-7
1-1480	Sub-47	3，4-diClPh	CO	Single bond	Sub-8
						1-1481	Sub-47	3，4-diClPh	CO	Single bond	Sub-9
1-1482	Sub-47	3，4-diClPh	CO	Single bond	Sub-10

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1483	Sub-47	3，4-diClPh	CO	Single bond	Sub-11
1-1484	Sub-47	3，4-diClPh	CO	Single bond	Sub-12
						1-1485	Sub-47	3，4-diClPh	CO	Single bond	Sub-13
1-1486	Sub-47	3，4-diClPh	CO	Single bond	Sub-14
						1-1487	Sub-47	3，4-diClPh	CO	Single bond	Sub-15
1-1488	Sub-47	3，4-diClPh	CO	Single bond	Sub-16
						1-1489	Sub-47	3，4-diClPh	CO	Single bond	Sub-17
1-1490	Sub-47	3，4-diClPh	CO	Single bond	Sub-18
						1-1491	Sub-47	3，4-diClPh	CO	Single bond	Sub-19
1-1492	Sub-47	3，4-diClPh	CO	Single bond	Sub-20
						1-1493	Sub-47	3，4-diClPh	CO	Single bond	Sub-21
1-1494	Sub-47	3，4-diClPh	CO	Single bond	Sub-22
						1-1495	Sub-47	3，4-diClPh	CO	Single bond	Sub-23
1-1496	Sub-47	3，4-diClPh	CO	Single bond	Sub-24
						1-1497	Sub-47	3，4-diClPh	CO	Single bond	Sub-25
1-1498	Sub-47	3，4-diClPh	CO	Single bond	Sub-26
						1-1499	Sub-47	3，4-diClPh	CO	Single bond	Sub-27
1-1500	Sub-47	3，4-diClPh	CO	Single bond	Sub-28
						1-1501	Sub-47	3，4-diClPh	CO	Single bond	Sub-29
1-1502	Sub-47	3，4-diClPh	CO	Single bond	Sub-30
						1-1503	Sub-47	3，4-diClPh	CO	Single bond	Sub-31
1-1504	Sub-47	3，4-diClPh	CO	Single bond	Sub-32
						1-1505	Sub-48	3，4-diClPh	CO	Single bond	Sub-1
1-1506	Sub-48	3，4-diClPh	CO	Single bond	Sub-2
						1-1507	Sub-48	3，4-diClPh	CO	Single bond	Sub-3
1-1508	Sub-48	3，4-diClPh	CO	Single bond	Sub-4

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1509	Sub-48	3，4-diClPh	CO	Single bond	Sub-5
1-1510	Sub-48	3，4-diClPh	CO	Single bond	Sub-6
						1-1511	Sub-48	3，4-diClPh	CO	Single bond	Sub-7
1-1512	Sub-48	3，4-diClPh	CO	Single bond	Sub-8
						1-1513	Sub-48	3，4-diClPh	CO	Single bond	Sub-9
1-1514	Sub-48	3，4-diClPh	CO	Single bond	Sub-10
						1-1515	Sub-48	3，4-diClPh	CO	Single bond	Sub-11
1-1516	Sub-48	3，4-diClPh	CO	Single bond	Sub-12
						1-1517	Sub-48	3，4-diClPh	CO	Single bond	Sub-13
1-1518	Sub-48	3，4-diClPh	CO	Single bond	Sub-14
						1-1519	Sub-48	3，4-diClPh	CO	Single bond	Sub-15
1-1520	Sub-48	3，4-diClPh	CO	Single bond	Sub-16
						1-1521	Sub-48	3，4-diClPh	CO	Single bond	Sub-17
1-1522	Sub-48	3，4-diClPh	CO	Single bond	Sub-18
						1-1523	Sub-48	3，4-diClPh	CO	Single bond	Sub-19
1-1524	Sub-48	3，4-diClPh	CO	Single bond	Sub-20
						1-1525	Sub-48	3，4-diClPh	CO	Single bond	Sub-21
1-1526	Sub-48	3，4-diClPh	CO	Single bond	Sub-22
						1-1527	Sub-48	3，4-diClPh	CO	Single bond	Sub-23
1-1528	Sub-48	3，4-diClPh	CO	Single bond	Sub-24
						1-1529	Sub-48	3，4-diClPh	CO	Single bond	Sub-25
1-1530	Sub-48	3，4-diClPh	CO	Single bond	Sub-26
						1-1531	Sub-48	3，4-diClPh	CO	Single bond	Sub-27
1-1532	Sub-48	3，4-diClPh	CO	Single bond	Sub-28
						1-1533	Sub-48	3，4-diClPh	CO	Single bond	Sub-29
1-1534	Sub-48	3，4-diClPh	CO	Single bond	Sub-30

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1535	Sub-48	3，4-diClPh	CO	Single bond	Sub-31
1-1536	Sub-48	3，4-diClPh	CO	Single bond	Sub-32
						1-1537	Sub-49	3，4-diClPh	CO	Single bond	Sub-1
1-1538	Sub-49	3，4-diClPh	CO	Single bond	Sub-2
						1-1539	Sub-49	3，4-diClPh	CO	Single bond	Sub-3
1-1540	Sub-49	3，4-diClPh	CO	Single bond	Sub-4
						1-1541	Sub-49	3，4-diClPh	CO	Single bond	Sub-5
1-1542	Sub-49	3，4-diClPh	CO	Single bond	Sub-6
						1-1543	Sub-49	3，4-diClPh	CO	Single bond	Sub-7
1-1544	Sub-49	3，4-diClPh	CO	Single bond	Sub-8
						1-1545	Sub-49	3，4-diClPh	CO	Single bond	Sub-9
1-1546	Sub-49	3，4-diClPh	CO	Single bond	Sub-10
						1-1547	Sub-49	3，4-diClPh	CO	Single bond	Sub-11
1-1548	Sub-49	3，4-diClPh	CO	Single bond	Sub-12
						1-1549	Sub-49	3，4-diClPh	CO	Single bond	Sub-13
1-1550	Sub-49	3，4-diClPh	CO	Single bond	Sub-14
						1-1551	Sub-49	3，4-diClPh	CO	Single bond	Sub-15
1-1552	Sub-49	3，4-diClPh	CO	Single bond	Sub-16
						1-1553	Sub-49	3，4-diClPh	CO	Single bond	Sub-17
1-1554	Sub-49	3，4-diClPh	CO	Single bond	Sub-18
						1-1555	Sub-49	3，4-diClPh	CO	Single bond	Sub-19
1-1556	Sub-49	3，4-diClPh	CO	Single bond	Sub-20
						1-1557	Sub-49	3，4-diClPh	CO	Single bond	Sub-21
1-1558	Sub-49	3，4-diClPh	CO	Single bond	Sub-22
						1-1559	Sub-49	3，4-diClPh	CO	Single bond	Sub-23
1-1560	Sub-49	3，4-diClPh	CO	Single bond	Sub-24

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1561	Sub-49	3，4-diClPh	CO	Single bond	Sub-25
1-1562	Sub-49	3，4-diClPh	CO	Single bond	Sub-26
						1-1563	Sub-49	3，4-diClPh	CO	Single bond	Sub-27
1-1564	Sub-49	3，4-diClPh	CO	Single bond	Sub-28
						1-1565	Sub-49	3，4-diClPh	CO	Single bond	Sub-29
1-1566	Sub-49	3，4-diClPh	CO	Single bond	Sub-30
						1-1567	Sub-49	3，4-diClPh	CO	Single bond	Sub-31
1-1568	Sub-49	3，4-diClPh	CO	Single bond	Sub-32
						1-1569	Sub-50	3，4-diClPh	CO	Single bond	Sub-1
1-1570	Sub-50	3，4-diClPh	CO	Single bond	Sub-2
						1-1571	Sub-50	3，4-diClPh	CO	Single bond	Sub-3
1-1572	Sub-50	3，4-diClPh	CO	Single bond	Sub-4
						1-1573	Sub-50	3，4-diClPh	CO	Single bond	Sub-5
1-1574	Sub-50	3，4-diClPh	CO	Single bond	Sub-6
						1-1575	Sub-50	3，4-diClPh	CO	Single bond	Sub-7
1-1576	Sub-50	3，4-diClPh	CO	Single bond	Sub-8
						1-1577	Sub-50	3，4-diClPh	CO	Single bond	Sub-9
1-1578	Sub-50	3，4-diClPh	CO	Single bond	Sub-10
						1-1579	Sub-50	3，4-diClPh	CO	Single bond	Sub-11
1-1580	Sub-50	3，4-diClPh	CO	Single bond	Sub-12
						1-1581	Sub-50	3，4-diClPh	CO	Single bond	Sub-13
1-1582	Sub-50	3，4-diClPh	CO	Single bond	Sub-14
						1-1583	Sub-50	3，4-diClPh	CO	Single bond	Sub-15
1-1584	Sub-50	3，4-diClPh	CO	Single bond	Sub-16
						1-1585	Sub-50	3，4-diClPh	CO	Single bond	Sub-17
1-1586	Sub-50	3，4-diClPh	CO	Single bond	Sub-18

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1587	Sub-50	3，4-diClPh	CO	Single bond	Sub-19
1-1588	Sub-50	3，4-diClPh	CO	Single bond	Sub-20
						1-1589	Sub-50	3，4-diClPh	CO	Single bond	Sub-21
1-1590	Sub-50	3，4-diClPh	CO	Single bond	Sub-22
						1-1591	Sub-50	3，4-diClPh	CO	Single bond	Sub-23
1-1592	Sub-50	3，4-diClPh	CO	Single bond	Sub-24
						1-1593	Sub-50	3，4-diClPh	CO	Single bond	Sub-25
1-1594	Sub-50	3，4-diClPh	CO	Single bond	Sub-26
						1-1595	Sub-50	3，4-diClPh	CO	Single bond	Sub-27
1-1596	Sub-50	3，4-diClPh	CO	Single bond	Sub-28
						1-1597	Sub-50	3，4-diClPh	CO	Single bond	Sub-29
1-1598	Sub-50	3，4-diClPh	CO	Single bond	Sub-30
						1-1599	Sub-50	3，4-diClPh	CO	Single bond	Sub-31
1-1600	Sub-50	3，4-diClPh	CO	Single bond	Sub-32
						1-1601	Sub-51	3，4-diClPh	CO	Single bond	Sub-1
1-1602	Sub-51	3，4-diClPh	CO	Single bond	Sub-2
						1-1603	Sub-51	3，4-diClPh	CO	Single bond	Sub-3
1-1604	Sub-51	3，4-diClPh	CO	Single bond	Sub-4
						1-1605	Sub-51	3，4-diClPh	CO	Single bond	Sub-5
1-1606	Sub-51	3，4-diClPh	CO	Single bond	Sub-6
						1-1607	Sub-51	3，4-diClPh	CO	Single bond	Sub-7
1-1608	Sub-51	3，4-diClPh	CO	Single bond	Sub-8
						1-1609	Sub-51	3，4-diClPh	CO	Single bond	Sub-9
1-1610	Sub-51	3，4-diClPh	CO	Single bond	Sub-10
						1-1611	Sub-51	3，4-diClPh	CO	Single bond	Sub-11
1-1612	Sub-51	3，4-diClPh	CO	Single bond	Sub-12

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1613	Sub-51	3，4-diClPh	CO	Single bond	Sub-13
1-1614	Sub-51	3，4-diClPh	CO	Single bond	Sub-14
						1-1615	Sub-51	3，4-diClPh	CO	Single bond	Sub-15
1-1616	Sub-51	3，4-diClPh	CO	Single bond	Sub-16
						1-1617	Sub-51	3，4-diClPh	CO	Single bond	Sub-17
1-1618	Sub-51	3，4-diClPh	CO	Single bond	Sub-18
						1-1619	Sub-51	3，4-diClPh	CO	Single bond	Sub-19
1-1620	Sub-51	3，4-diClPh	CO	Single bond	Sub-20
						1-1621	Sub-51	3，4-diClPh	CO	Single bond	Sub-21
1-1622	Sub-51	3，4-diClPh	CO	Single bond	Sub-22
						1-1623	Sub-51	3，4-diClPh	CO	Single bond	Sub-23
1-1624	Sub-51	3，4-diClPh	CO	Single bond	Sub-24
						1-1625	Sub-51	3，4-diClPh	CO	Single bond	Sub-25
1-1626	Sub-51	3，4-diClPh	CO	Single bond	Sub-26
						1-1627	Sub-51	3，4-diClPh	CO	Single bond	Sub-27
1-1628	Sub-51	3，4-diClPh	CO	Single bond	Sub-28
						1-1629	Sub-51	3，4-diClPh	CO	Single bond	Sub-29
1-1630	Sub-51	3，4-diClPh	CO	Single bond	Sub-30
						1-1631	Sub-51	3，4-diClPh	CO	Single bond	Sub-31
1-1632	Sub-51	3，4-diClPh	CO	Single bond	Sub-32
						1-1633	Sub-52	3，4-diClPh	CO	Single bond	Sub-1
1-1634	Sub-52	3，4-diClPh	CO	Single bond	Sub-2
						1-1635	Sub-52	3，4-diClPh	CO	Single bond	Sub-3
1-1636	Sub-52	3，4-diClPh	CO	Single bond	Sub-4
						1-1637	Sub-52	3，4-diClPh	CO	Single bond	Sub-5
1-1638	Sub-52	3，4-diClPh	CO	Single bond	Sub-6

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1639	Sub-52	3，4-diClPh	CO	Single bond	Sub-7
1-1640	Sub-52	3，4-diClPh	CO	Single bond	Sub-8
						1-1641	Sub-52	3，4-diClPh	CO	Single bond	Sub-9
1-1642	Sub-52	3，4-diClPh	CO	Single bond	Sub-10
						1-1643	Sub-52	3，4-diClPh	CO	Single bond	Sub-11
1-1644	Sub-52	3，4-diClPh	CO	Single bond	Sub-12
						1-1645	Sub-52	3，4-diClPh	CO	Single bond	Sub-13
1-1646	Sub-52	3，4-diClPh	CO	Single bond	Sub-14
						1-1647	Sub-52	3，4-diClPh	CO	Single bond	Sub-15
1-1648	Sub-52	3，4-diClPh	CO	Single bond	Sub-16
						1-1649	Sub-52	3，4-diClPh	CO	Single bond	Sub-17
1-1650	Sub-52	3，4-diClPh	CO	Single bond	Sub-18
						1-1651	Sub-52	3，4-diClPh	CO	Single bond	Sub-19
1-1652	Sub-52	3，4-diClPh	CO	Single bond	Sub-20
						1-1653	Sub-52	3，4-diClPh	CO	Single bond	Sub-21
1-1654	Sub-52	3，4-diClPh	CO	Single bond	Sub-22
						1-1655	Sub-52	3，4-diClPh	CO	Single bond	Sub-23
1-1656	Sub-52	3，4-diClPh	CO	Single bond	Sub-24
						1-1657	Sub-52	3，4-diClPh	CO	Single bond	Sub-25
1-1658	Sub-52	3，4-diClPh	CO	Single bond	Sub-26
						1-1659	Sub-52	3，4-diClPh	CO	Single bond	Sub-27
1-1660	Sub-52	3，4-diClPh	CO	Single bond	Sub-28
						1-1661	Sub-52	3，4-diClPh	CO	Single bond	Sub-29
1-1662	Sub-52	3，4-diClPh	CO	Single bond	Sub-30
						1-1663	Sub-52	3，4-diClPh	CO	Single bond	Sub-31
1-1664	Sub-52	3，4-diClPh	CO	Single bond	Sub-32

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1665	Sub-53	3，4-diClPh	CO	Single bond	Sub-1
1-1666	Sub-53	3，4-diClPh	CO	Single bond	Sub-2
						1-1667	Sub-53	3，4-diClPh	CO	Single bond	Sub-3
1-1668	Sub-53	3，4-diClPh	CO	Single bond	Sub-4
						1-1669	Sub-53	3，4-diClPh	CO	Single bond	Sub-5
1-1670	Sub-53	3，4-diClPh	CO	Single bond	Sub-6
						1-1671	Sub-53	3，4-diClPh	CO	Single bond	Sub-7
1-1672	Sub-53	3，4-diClPh	CO	Single bond	Sub-8
						1-1673	Sub-53	3，4-diClPh	CO	Single bond	Sub-9
1-1674	Sub-53	3，4-diClPh	CO	Single bond	Sub-10
						1-1675	Sub-53	3，4-diClPh	CO	Single bond	Sub-11
1-1676	Sub-53	3，4-diClPh	CO	Single bond	Sub-12
						1-1677	Sub-53	3，4-diClPh	CO	Single bond	Sub-13
1-1678	Sub-53	3，4-diClPh	CO	Single bond	Sub-14
						1-1679	Sub-53	3，4-diClPh	CO	Single bond	Sub-15
1-1680	Sub-53	3，4-diClPh	CO	Single bond	Sub-16
						1-1681	Sub-53	3，4-diClPh	CO	Single bond	Sub-17
1-1682	Sub-53	3，4-diClPh	CO	Single bond	Sub-18
						1-1683	Sub-53	3，4-diClPh	CO	Single bond	Sub-19
1-1684	Sub-53	3，4-diClPh	CO	Single bond	Sub-20
						1-1685	Sub-53	3，4-diClPh	CO	Single bond	Sub-21
1-1686	Sub-53	3，4-diClPh	CO	Single bond	Sub-22
						1-1687	Sub-53	3，4-diClPh	CO	Single bond	Sub-23
1-1688	Sub-53	3，4-diClPh	CO	Single bond	Sub-24
						1-1689	Sub-53	3，4-diClPh	CO	Single bond	Sub-25
1-1690	Sub-53	3，4-diClPh	CO	Single bond	Sub-26

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1691	Sub-53	3，4-diClPh	CO	Single bond	Sub-27
1-1692	Sub-53	3，4-diClPh	CO	Single bond	Sub-28
						1-1693	Sub-53	3，4-diClPh	CO	Single bond	Sub-29
1-1694	Sub-53	3，4-diClPh	CO	Single bond	Sub-30
						1-1695	Sub-53	3，4-diClPh	CO	Single bond	Sub-31
1-1696	Sub-53	3，4-diClPh	CO	Single bond	Sub-32
						1-1697	Sub-54	3，4-diClPh	CO	Single bond	Sub-1
1-1698	Sub-54	3，4-diClPh	CO	Single bond	Sub-2
						1-1699	Sub-54	3，4-diClPh	CO	Single bond	Sub-3
1-1700	Sub-54	3，4-diClPh	CO	Single bond	Sub-4
						1-1701	Sub-54	3，4-diClPh	CO	Single bond	Sub-5
1-1702	Sub-54	3，4-diClPh	CO	Single bond	Sub-6
						1-1703	Sub-54	3，4-diClPh	CO	Single bond	Sub-7
1-1704	Sub-54	3，4-diClPh	CO	Single bond	Sub-8
						1-1705	Sub-54	3，4-diClPh	CO	Single bond	Sub-9
1-1706	Sub-54	3，4-diClPh	CO	Single bond	Sub-10
						1-1707	Sub-54	3，4-diClPh	CO	Single bond	Sub-11
1-1708	Sub-54	3，4-diClPh	CO	Single bond	Sub-12
						1-1709	Sub-54	3，4-diClPh	CO	Single bond	Sub-13
1-1710	Sub-54	3，4-diClPh	CO	Single bond	Sub-14
						1-1711	Sub-54	3，4-diClPh	CO	Single bond	Sub-15
1-1712	Sub-54	3，4-diClPh	CO	Single bond	Sub-16
						1-1713	Sub-54	3，4-diClPh	CO	Single bond	Sub-17
1-1714	Sub-54	3，4-diClPh	CO	Single bond	Sub-18
						1-1715	Sub-54	3，4-diClPh	CO	Single bond	Sub-19
1-1716	Sub-54	3，4-diClPh	CO	Single bond	Sub-20

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1717	Sub-54	3，4-diClPh	CO	Single bond	Sub-21
1-1718	Sub-54	3，4-diClPh	CO	Single bond	Sub-22
						1-1719	Sub-54	3，4-diClPh	CO	Single bond	Sub-23
1-1720	Sub-54	3，4-diClPh	CO	Single bond	Sub-24
						1-1721	Sub-54	3，4-diClPh	CO	Single bond	Sub-25
1-1722	Sub-54	3，4-diClPh	CO	Single bond	Sub-26
						1-1723	Sub-54	3，4-diClPh	CO	Single bond	Sub-27
1-1724	Sub-54	3，4-diClPh	CO	Single bond	Sub-28
						1-1725	Sub-54	3，4-diClPh	CO	Single bond	Sub-29
1-1726	Sub-54	3，4-diClPh	CO	Single bond	Sub-30
						1-1727	Sub-54	3，4-diClPh	CO	Single bond	Sub-31
1-1728	Sub-54	3，4-diClPh	CO	Single bond	Sub-32
						1-1729	Sub-55	3，4-diClPh	CO	Single bond	Sub-1
1-1730	Sub-55	3，4-diClPh	CO	Single bond	Sub-2
						1-1731	Sub-55	3，4-diClPh	CO	Single bond	Sub-3
1-1732	Sub-55	3，4-diClPh	CO	Single bond	Sub-4
						1-1733	Sub-55	3，4-diClPh	CO	Single bond	Sub-5
1-1734	Sub-55	3，4-diClPh	CO	Single bond	Sub-6
						1-1735	Sub-55	3，4-diClPh	CO	Single bond	Sub-7
1-1736	Sub-55	3，4-diClPh	CO	Single bond	Sub-8
						1-1737	Sub-55	3，4-diClPh	CO	Single bond	Sub-9
1-1738	Sub-55	3，4-diClPh	CO	Single bond	Sub-10
						1-1739	Sub-55	3，4-diClPh	CO	Single bond	Sub-11
1-1740	Sub-55	3，4-diClPh	CO	Single bond	Sub-12
						1-1741	Sub-55	3，4-diClPh	CO	Single bond	Sub-13
1-1742	Sub-55	3，4-diClPh	CO	Single bond	Sub-14

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1743	Sub-55	3，4-diClPh	CO	Single bond	Sub-15
1-1744	Sub-55	3，4-diClPh	CO	Single bond	Sub-16
						1-1745	Sub-55	3，4-diClPh	CO	Single bond	Sub-17
1-1746	Sub-55	3，4-diClPh	CO	Single bond	Sub-18
						1-1747	Sub-55	3，4-diClPh	CO	Single bond	Sub-19
1-1748	Sub-55	3，4-diClPh	CO	Single bond	Sub-20
						1-1749	Sub-55	3，4-diClPh	CO	Single bond	Sub-21
1-1750	Sub-55	3，4-diClPh	CO	Single bond	Sub-22
						1-1751	Sub-55	3，4-diClPh	CO	Single bond	Sub-23
1-1752	Sub-55	3，4-diClPh	CO	Single bond	Sub-24
						1-1753	Sub-55	3，4-diClPh	CO	Single bond	Sub-25
1-1754	Sub-55	3，4-diClPh	CO	Single bond	Sub-26
						1-1755	Sub-55	3，4-diClPh	CO	Single bond	Sub-27
1-1756	Sub-55	3，4-diClPh	CO	Single bond	Sub-28
						1-1757	Sub-55	3，4-diClPh	CO	Single bond	Sub-29
1-1758	Sub-55	3，4-diClPh	CO	Single bond	Sub-30
						1-1759	Sub-55	3，4-diClPh	CO	Single bond	Sub-31
1-1760	Sub-55	3，4-diClPh	CO	Single bond	Sub-32
						1-1761	Sub-56	3，4-diClPh	CO	Single bond	Sub-1
1-1762	Sub-56	3，4-diClPh	CO	Single bond	Sub-2
						1-1763	Sub-56	3，4-diClPh	CO	Single bond	Sub-3
1-1764	Sub-56	3，4-diClPh	CO	Single bond	Sub-4
						1-1765	Sub-56	3，4-diClPh	CO	Single bond	Sub-5
1-1766	Sub-56	3，4-diClPh	CO	Single bond	Sub-6
						1-1767	Sub-56	3，4-diClPh	CO	Single bond	Sub-7
1-1768	Sub-56	3，4-diClPh	CO	Single bond	Sub-8

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1769	Sub-56	3，4-diClPh	CO	Single bond	Sub-9
1-1770	Sub-56	3，4-diClPh	CO	Single bond	Sub-10
						1-1771	Sub-56	3，4-diClPh	CO	Single bond	Sub-11
1-1772	Sub-56	3，4-diClPh	CO	Single bond	Sub-12
						1-1773	Sub-56	3，4-diClPh	CO	Single bond	Sub-13
1-1774	Sub-56	3，4-diClPh	CO	Single bond	Sub-14
						1-1775	Sub-56	3，4-diClPh	CO	Single bond	Sub-15
1-1776	Sub-56	3，4-diClPh	CO	Single bond	Sub-16
						1-1777	Sub-56	3，4-diClPh	CO	Single bond	Sub-17
1-1778	Sub-56	3，4-diClPh	CO	Single bond	Sub-18
						1-1779	Sub-56	3，4-diClPh	CO	Single bond	Sub-19
1-1780	Sub-56	3，4-diClPh	CO	Single bond	Sub-20
						1-1781	Sub-56	3，4-diClPh	CO	Single bond	Sub-21
1-1782	Sub-56	3，4-diClPh	CO	Single bond	Sub-22
						1-1783	Sub-56	3，4-diClPh	CO	Single bond	Sub-23
1-1784	Sub-56	3，4-diClPh	CO	Single bond	Sub-24
						1-1785	Sub-56	3，4-diClPh	CO	Single bond	Sub-25
1-1786	Sub-56	3，4-diClPh	CO	Single bond	Sub-26
						1-1787	Sub-56	3，4-diClPh	CO	Single bond	Sub-27
1-1788	Sub-56	3，4-diClPh	CO	Single bond	Sub-28
						1-1789	Sub-56	3，4-diClPh	CO	Single bond	Sub-29
1-1790	Sub-56	3，4-diClPh	CO	Single bond	Sub-30
						1-1791	Sub-56	3，4-diClPh	CO	Single bond	Sub-31
1-1792	Sub-56	3，4-diClPh	CO	Single bond	Sub-32
						1-1793	Sub-57	3，4-diClPh	CO	Single bond	Sub-1
1-1794	Sub-57	3，4-diClPh	CO	Single bond	Sub-2

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1795	Sub-57	3，4-diClPh	CO	Single bond	Sub-3
1-1796	Sub-57	3，4-diClPh	CO	Single bond	Sub-4
						1-1797	Sub-57	3，4-diClPh	CO	Single bond	Sub-5
1-1798	Sub-57	3，4-diClPh	CO	Single bond	Sub-6
						1-1799	Sub-57	3，4-diClPh	CO	Single bond	Sub-7
1-1800	Sub-57	3，4-diClPh	CO	Single bond	Sub-8
						1-1801	Sub-57	3，4-diClPh	CO	Single bond	Sub-9
1-1802	Sub-57	3，4-diClPh	CO	Single bond	Sub-10
						1-1803	Sub-57	3，4-diClPh	CO	Single bond	Sub-11
1-1804	Sub-57	3，4-diClPh	CO	Single bond	Sub-12
						1-1805	Sub-57	3，4-diClPh	CO	Single bond	Sub-13
1-1806	Sub-57	3，4-diClPh	CO	Single bond	Sub-14
						1-1807	Sub-57	3，4-diClPh	CO	Single bond	Sub-15
1-1808	Sub-57	3，4-diClPh	CO	Single bond	Sub-16
						1-1809	Sub-57	3，4-diClPh	CO	Single bond	Sub-17
1-1810	Sub-57	3，4-diClPh	CO	Single bond	Sub-18
						1-1811	Sub-57	3，4-diClPh	CO	Single bond	Sub-19
1-1812	Sub-57	3，4-diClPh	CO	Single bond	Sub-20
						1-1813	Sub-57	3，4-diClPh	CO	Single bond	Sub-21
1-1814	Sub-57	3，4-diClPh	CO	Single bond	Sub-22
						1-1815	Sub-57	3，4-diClPh	CO	Single bond	Sub-23
1-1816	Sub-57	3，4-diClPh	CO	Single bond	Sub-24
						1-1817	Sub-57	3，4-diClPh	CO	Single bond	Sub-25
1-1818	Sub-57	3，4-diClPh	CO	Single bond	Sub-26
						1-1819	Sub-57	3，4-diClPh	CO	Single bond	Sub-27
1-1820	Sub-57	3，4-diClPh	CO	Single bond	Sub-28

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1821	Sub-57	3，4-diClPh	CO	Single bond	Sub-29
1-1822	Sub-57	3，4-diClPh	CO	Single bond	Sub-30
						1-1 823	Sub-57	3，4-diClPh	CO	Single bond	Sub-31
1-1824	Sub-57	3，4-diClPh	CO	Single bond	Sub-32
						1-1825	Sub-58	3，4-diClPh	CO	Single bond	Sub-1
1-1826	Sub-58	3，4-diClPh	CO	Single bond	Sub-2
						1-1827	Sub-58	3，4-diClPh	CO	Single bond	Sub-3
1-1828	Sub-58	3，4-diClPh	CO	Single bond	Sub-4
						1-1829	Sub-58	3，4-diClPh	CO	Single bond	Sub-5
1-1830	Sub-58	3，4-diClPh	CO	Single bond	Sub-6
						1-1831	Sub-58	3，4-diClPh	CO	Single bond	Sub-7
1-1832	Sub-58	3，4-diClPh	CO	Single bond	Sub-8
						1-1833	Sub-58	3，4-diClPh	CO	Single bond	Sub-9
1-1834	Sub-58	3，4-diClPh	CO	Single bond	Sub-10
						1-1835	Sub-58	3，4-diClPh	CO	Single bond	Sub-11
1-1836	Sub-58	3，4-diClPh	CO	Single bond	Sub-12
						1-1837	Sub-58	3，4-diClPh	CO	Single bond	Sub-13
1-1838	Sub-58	3，4-diClPh	CO	Single bond	Sub-14
						1-1839	Sub-58	3，4-diClPh	CO	Single bond	Sub-15
1-1840	Sub-58	3，4-diClPh	CO	Single bond	Sub-16
						1-1841	Sub-58	3，4-diClPh	CO	Single bond	Sub-17
1-1842	Sub-58	3，4-diClPh	CO	Single bond	Sub-18
						1-1843	Sub-58	3，4-diClPh	CO	Single bond	Sub-19
1-1844	Sub-58	3，4-diClPh	CO	Single bond	Sub-20
						1-1845	Sub-58	3，4-diClPh	CO	Single bond	Sub-21
1-1846	Sub-58	3，4-diClPh	CO	Single bond	Sub-22

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1847	Sub-58	3，4-diClPh	CO	Single bond	Sub-23
1-1848	Sub-58	3，4-diClPh	CO	Single bond	Sub-24
						1-1849	Sub-58	3，4-diClPh	CO	Single bond	Sub-25
1-1850	Sub-58	3，4-diClPh	CO	Single bond	Sub-26
						1-1851	Sub-58	3，4-diClPh	CO	Single bond	Sub-27
1-1852	Sub-58	3，4-diClPh	CO	Single bond	Sub-28
						1-1853	Sub-58	3，4-diClPh	CO	Single bond	Sub-29
1-1854	Sub-58	3，4-diClPh	CO	Single bond	Sub-30
						1-1855	Sub-58	3，4-diClPh	CO	Single bond	Sub-31
1-1856	Sub-58	3，4-diClPh	CO	Single bond	Sub-32
						1-1857	Sub-59	3，4-diClPh	CO	Single bond	Sub-1
1-1858	Sub-59	3，4-diClPh	CO	Single bond	Sub-2
						1-1859	Sub-59	3，4-diClPh	CO	Single bond	Sub-3
1-1860	Sub-59	3，4-diClPh	CO	Single bond	Sub-4
						1-1861	Sub-59	3，4-diClPh	CO	Single bond	Sub-5
1-1862	Sub-59	3，4-diClPh	CO	Single bond	Sub-6
						1-1863	Sub-59	3，4-diClPh	CO	Single bond	Sub-7
1-1864	Sub-59	3，4-diClPh	CO	Single bond	Sub-8
						1-1865	Sub-59	3，4-diClPh	CO	Single bond	Sub-9
1-1866	Sub-59	3，4-diClPh	CO	Single bond	Sub-10
						1-1867	Sub-59	3，4-diClPh	CO	Single bond	Sub-11
1-1868	Sub-59	3，4-diClPh	CO	Single bond	Sub-12
						1-1869	Sub-59	3，4-diClPh	CO	Single bond	Sub-13
1-1870	Sub-59	3，4-diClPh	CO	Single bond	Sub-14
						1-1871	Sub-59	3，4-diClPh	CO	Single bond	Sub-15
1-1872	Sub-59	3，4-diClPh	CO	Single bond	Sub-16

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1873	Sub-59	3，4-diClPh	CO	Single bond	Sub-17
1-1874	Sub-59	3，4-diClPh	CO	Single bond	Sub-18
						1-1875	Sub-59	3，4-diClPh	CO	Single bond	Sub-19
1-1876	Sub-59	3，4-diClPh	CO	Single bond	Sub-20
						1-1877	Sub-59	3，4-diClPh	CO	Single bond	Sub-21
1-1878	Sub-59	3，4-diClPh	CO	Single bond	Sub-22
						1-1879	Sub-59	3，4-diClPh	CO	Single bond	Sub-23
1-1880	Sub-59	3，4-diClPh	CO	Single bond	Sub-24
						1-1881	Sub-59	3，4-diClPh	CO	Single bond	Sub-25
1-1882	Sub-59	3，4-diClPh	CO	Single bond	Sub-26
						1-1883	Sub-59	3，4-diClPh	CO	Single bond	Sub-27
1-1884	Sub-59	3，4-diClPh	CO	Single bond	Sub-28
						1-1885	Sub-59	3，4-diClPh	CO	Single bond	Sub-29
1-1886	Sub-59	3，4-diClPh	CO	Single bond	Sub-30
						1-1887	Sub-59	3，4-diClPh	CO	Single bond	Sub-31
1-1888	Sub-59	3，4-diClPh	CO	Single bond	Sub-32
						1-1889	Sub-60	3，4-diClPh	CO	Single bond	Sub-1
1-1890	Sub-60	3，4-diClPh	CO	Single bond	Sub-2
						1-1891	Sub-60	3，4-diClPh	CO	Single bond	Sub-3
1-1892	Sub-60	3，4-diClPh	CO	Single bond	Sub-4
						1-1893	Sub-60	3，4-diClPh	CO	Single bond	Sub-5
1-1894	Sub-60	3，4-diClPh	CO	Single bond	Sub-6
						1-1895	Sub-60	3，4-diClPh	CO	Single bond	Sub-7
1-1896	Sub-60	3，4-diClPh	CO	Single bond	Sub-8
						1-1897	Sub-60	3，4-diClPh	CO	Single bond	Sub-9
1-1898	Sub-60	3，4-diClPh	CO	Single bond	Sub-10

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1899	Sub-60	3，4-diClPh	CO	Single bond	Sub-11
1-1900	Sub-60	3，4-diClPh	CO	Single bond	Sub-12
						1-1901	Sub-60	3，4-diClPh	CO	Single bond	Sub-13
1-1902	Sub-60	3，4-diClPh	CO	Single bond	Sub-14
						1-1903	Sub-60	3，4-diClPh	CO	Single bond	Sub-15
1-1904	Sub-60	3，4-diClPh	CO	Single bond	Sub-16
						1-1905	Sub-60	3，4-diClPh	CO	Single bond	Sub-17
1-1906	Sub-60	3，4-diClPh	CO	Single bond	Sub-18
						1-1907	Sub-60	3，4-diClPh	CO	Single bond	Sub-19
1-1908	Sub-60	3，4-diClPh	CO	Single bond	Sub-20
						1-1909	Sub-60	3，4-diClPh	CO	Single bond	Sub-21
1-1910	Sub-60	3，4-diClPh	CO	Single bond	Sub-22
						1-1911	Sub-60	3，4-diClPh	CO	Single bond	Sub-23
1-1912	Sub-60	3，4-diClPh	CO	Single bond	Sub-24
						1-1913	Sub-60	3，4-diClPh	CO	Single bond	Sub-25
1-1914	Sub-60	3，4-diClPh	CO	Single bond	Sub-26
						1-1915	Sub-60	3，4-diClPh	CO	Single bond	Sub-27
1-1916	Sub-60	3，4-diClPh	CO	Single bond	Sub-28
						1-1917	Sub-60	3，4-diClPh	CO	Single bond	Sub-29
1-1918	Sub-60	3，4-diClPh	CO	Single bond	Sub-30
						1-1919	Sub-60	3，4-diClPh	CO	Single bond	Sub-31
1-1920	Sub-60	3，4-dtClPh	CO	Single bond	Sub-32
						1-1921	Sub-61	3，4-diClPh	CO	Single bond	Sub-1
1-1922	Sub-61	3，4-diClPh	CO	Single bond	Sub-2
						1-1923	Sub-61	3，4-diClPh	CO	Single bond	Sub-3
1-1924	Sub-61	3，4-diClPh	CO	Single bond	Sub-4

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1925	Sub-61	3，4-diClPh	CO	Single bond	Sub-5
1-1926	Sub-61	3，4-diClPh	CO	Single bond	Sub-6
						1-1927	Sub-61	3，4-diClPh	CO	Single bond	Sub-7
1-1928	Sub-61	3，4-diClPh	CO	Single bond	Sub-8
						1-1929	Sub-61	3，4-diClPh	CO	Single bond	Sub-9
1-1930	Sub-61	3，4-diClPh	CO	Single bond	Sub-10
						1-1931	Sub-61	3，4-diClPh	CO	Single bond	Sub-11
1-1932	Sub-61	3，4-diClPh	CO	Single bond	Sub-12
						1-1933	Sub-61	3，4-diClPh	CO	Single bond	Sub-13
1-1934	Sub-61	3，4-diClPh	CO	Single bond	Sub-14
						1-1935	Sub-61	3，4-diClPh	CO	Single bond	Sub-15
1-1936	Sub-61	3，4-diClPh	CO	Single bond	Sub-16
						1-1937	Sub-61	3，4-diClPh	CO	Single bond	Sub-17
1-1938	Sub-61	3，4-diClPh	CO	Single bond	Sub-18
						1-1939	Sub-61	3，4-diClPh	CO	Single bond	Sub-19
1-1940	Sub-61	3，4-diClPh	CO	Single bond	Sub-20
						1-1941	Sub-61	3，4-diClPh	CO	Single bond	Sub-21
1-1942	Sub-61	3，4-diClPh	CO	Single bond	Sub-22
						1-1943	Sub-61	3，4-diClPh	CO	Single bond	Sub-23
1-1944	Sub-61	3，4-diClPh	CO	Single bond	Sub-24
						1-1945	Sub-61	3，4-diClPh	CO	Single bond	Sub-25
1-1946	Sub-61	3，4-diClPh	CO	Single bond	Sub-26
						1-1947	Sub-61	3，4-diClPh	CO	Single bond	Sub-27
1-1948	Sub-61	3，4-diClPh	CO	Single bond	Sub-28
						1-1949	Sub-61	3，4-diClPh	CO	Single bond	Sub-29
1-1950	Sub-61	3，4-diClPh	CO	Single bond	Sub-30

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1951	Sub-61	3，4-diClPh	CO	Single bond	Sub-31
1-1952	Sub-61	3，4-diClPh	CO	Single bond	Sub-32
						1-1953	Sub-62	3，4-diClPh	CO	Single bond	Sub-1
1-1954	Sub-62	3，4-diClPh	CO	Single bond	Sub-2
						1-1955	Sub-62	3，4-diClPh	CO	Single bond	Sub-3
1-1956	Sub-62	3，4-diClPh	CO	Single bond	Sub-4
						1-1957	Sub-62	3，4-diClPh	CO	Single bond	Sub-5
1-1958	Sub-62	3，4-diClPh	CO	Single bond	Sub-6
						1-1959	Sub-62	3，4-diClPh	CO	Single bond	Sub-7
1-1960	Sub-62	3，4-diClPh	CO	Single bond	Sub-8
						1-1961	Sub-62	3，4-diClPh	CO	Single bond	Sub-9
1-1962	Sub-62	3，4-diClPh	CO	Single bond	Sub-10
						1-1963	Sub-62	3，4-diClPh	CO	Single bond	Sub-11
1-1964	Sub-62	3，4-diClPh	CO	Single bond	Sub-12
						1-1965	Sub-62	3，4-diClPh	CO	Single bond	Sub-13
1-1966	Sub-62	3，4-diClPh	CO	Single bond	Sub-14
						1-1967	Sub-62	3，4-diClPh	CO	Single bond	Sub-15
1-1968	Sub-62	3，4-diClPh	CO	Single bond	Sub-16
						1-1969	Sub-62	3，4-diClPh	CO	Single bond	Sub-17
1-1970	Sub-62	3，4-diClPh	CO	Single bond	Sub-18
						1-1971	Sub-62	3，4-diClPh	CO	Single bond	Sub-19
1-1972	Sub-62	3，4-diClPh	CO	Single bond	Sub-20
						1-1973	Sub-62	3，4-diClPh	CO	Single bond	Sub-21
1-1974	Sub-62	3，4-diClPh	CO	Single bond	Sub-22
						1-1975	Sub-62	3，4-diClPh	CO	Single bond	Sub-23
1-1976	Sub-62	3，4-diClPh	CO	Single bond	Sub-24

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-1977	Sub-62	3，4-diClPh	CO	Single bond	Sub-25
1-1978	Sub-62	3，4-diClPh	CO	Single bond	Sub-26
						1-1979	Sub-62	3，4-diClPh	CO	Single bond	Sub-27
1-1980	Sub-62	3，4-diClPh	CO	Single bond	Sub-28
						1-1981	Sub-62	3，4-diClPh	CO	Single bond	Sub-29
1-1982	Sub-62	3，4-diClPh	CO	Single bond	Sub-30
						1-1983	Sub-62	3，4-diClPh	CO	Single bond	Sub-31
1-1984	Sub-62	3，4-diClPh	CO	Single bond	Sub-32
						1-1985	Sub-63	3，4-diClPh	CO	Single bond	Sub-1
1-1986	Sub-63	3，4-diClPh	CO	Single bond	Sub-2
						1-1987	Sub-63	3，4-diClPh	CO	Single bond	Sub-3
1-1988	Sub-63	3，4-diClPh	CO	Single bond	Sub-4
						1-1989	Sub-63	3，4-diClPh	CO	Single bond	Sub-5
1-1990	Sub-63	3，4-diClPh	CO	Single bond	Sub-6
						1-1991	Sub-63	3，4-diClPh	CO	Single bond	Sub-7
1-1992	Sub-63	3，4-diClPh	CO	Single bond	Sub-8
						1-1993	Sub-63	3，4-diClPh	CO	Single bond	Sub-9
1-1994	Sub-63	3，4-diClPh	CO	Single bond	Sub-10
						1-1995	Sub-63	3，4-diClPh	CO	Single bond	Sub-11
1-1996	Sub-63	3，4-diclPh	CO	Single bond	Sub-12
						1-1997	Sub-63	3，4-diClPh	CO	Single bond	Sub-13
1-1998	Sub-63	3，4-diClPh	CO	Single bond	Sub-14
						1-1999	Sub-63	3，4-diClPh	CO	Single bond	Sub-15
1-2000	Sub-63	3，4-diClPh	CO	Single bond	Sub-16
						1-2001	Sub-63	3，4-diClPh	CO	Single bond	Sub-17
1-2002	Sub-63	3，4-diClPh	CO	Single bond	Sub-18

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2003	Sub-63	3，4-diClPh	CO	Single bond	Sub-19
1-2004	Sub-63	3，4-diClPh	CO	Single bond	Sub-20
						1-2005	Sub-63	3，4-diClPh	CO	Single bond	Sub-21
1-2006	Sub-63	3，4-diClPh	CO	Single bond	Sub-22
						1-2007	Sub-63	3，4-diClPh	CO	Single bond	Sub-23
1-2008	Sub-63	3，4-diClPh	CO	Single bond	Sub-24
						1-2009	Sub-63	3，4-diClPh	CO	Single bond	Sub-25
1-2010	Sub-63	3，4-diClPh	CO	Single bond	Sub-26
						1-2011	Sub-63	3，4-diClPh	CO	Single bond	Sub-27
1-2012	Sub-63	3，4-diClPh	CO	Single bond	Sub-28
						1-2013	Sub-63	3，4-diClPh	CO	Single bond	Sub-29
1-2014	Sub-63	3，4-diClPh	CO	Single bond	Sub-30
						1-2015	Sub-63	3，4-diClPh	CO	Single bond	Sub-31
1-2016	Sub-63	3，4-diClPh	CO	Single bond	Sub-32
						1-2017	Sub-64	3，4-diClPh	CO	Single bond	Sub-1
1-2018	Sub-64	3，4-diClPh	CO	Single bond	Sub-2
						1-2019	Sub-64	3，4-diClPh	CO	Single bond	Sub-3
1-2020	Sub-64	3，4-diClPh	CO	Single bond	Sub-4
						1-2021	Sub-64	3，4-diClPh	CO	Single bond	Sub-5
1-2022	Sub-64	3，4-diClPh	CO	Single bond	Sub-6
						1-2023	Sub-64	3，4-diClPh	CO	Single bond	Sub-7
1-2024	Sub-64	3，4-diClPh	CO	Single bond	Sub-8
						1-2025	Sub-64	3，4-diClPh	CO	Single bond	Sub-9
1-2026	Sub-64	3，4-diClPh	CO	Single bond	Sub-10
						1-2027	Sub-64	3，4-diClPh	CO	Single bond	Sub-11
1-2028	Sub-64	3，4-diClPh	CO	Single bond	Sub-12

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2029	Sub-64	3，4-diClPh	CO	Single bond	Sub-13
1-2030	Sub-64	3，4-diClPh	CO	Single bond	Sub-14
						1-2031	Sub-64	3，4-diClPh	CO	Single bond	Sub-15
1-2032	Sub-64	3，4-diClPh	CO	Single bond	Sub-16
						1-2033	Sub-64	3，4-diClPh	CO	Single bond	Sub-17
1-2034	Sub-64	3，4-diClPh	CO	Single bond	Sub-18
						1-2035	Sub-64	3，4-diClPh	CO	Single bond	Sub-19
1-2036	Sub-64	3，4-diClPh	CO	Single bond	Sub-20
						1-2037	Sub-64	3，4-diClPh	CO	Single bond	Sub-21
1-2038	Sub-64	3，4-diClPh	CO	Single bond	Sub-22
						1-2039	Sub-64	3，4-diClPh	CO	Single bond	Sub-23
1-2040	Sub-64	3，4-diClPh	CO	Single bond	Sub-24
						1-2041	Sub-64	3，4-diClPh	CO	Single bond	Sub-25
1-2042	Sub-64	3，4-diClPh	CO	Single bond	Sub-26
						1-2043	Sub-64	3，4-diClPh	CO	Single bond	Sub-27
1-2044	Sub-64	3，4-diClPh	CO	Single bond	Sub-28
						1-2045	Sub-64	3，4-diClPh	CO	Single bond	Sub-29
1-2046	Sub-64	3，4-diClPh	CO	Single bond	Sub-30
						1-2047	Sub-64	3，4-diClPh	CO	Single bond	Sub-31
1-2048	Sub-64	3，4-diClPh	CO	Single bond	Sub-32
						1-2049	Sub-33	3，4-diClPh	SO2	Single bond	Sub-1
1-2050	Sub-33	3，4-diClPh	SO2	Single bond	Sub-2
						1-2051	Sub-33	3，4-diClPh	SO2	Single bond	Sub-3
1-2052	Sub-33	3，4-diClPh	SO2	Single bond	Sub-4
						1-2053	Sub-33	3，4-diClPh	SO2	Single bond	Sub-5
1-2054	Sub-33	3，4-diClPh	SO2	Single bond	Sub-6

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2055	Sub-33	3，4-diClPh	SO2	Single bond	Sub-7
1-2056	Sub-33	3，4-diClPh	SO2	Single bond	Sub-8
						1-2057	Sub-33	3，4-diClPh	SO2	Single bond	Sub-9
1-2058	Sub-33	3，4-diClPh	SO2	Single bond	Sub-10
						1-2059	Sub-33	3，4-diClPh	SO2	Single bond	Sub-11
1-2060	Sub-33	3，4-diClPh	SO2	Single bond	Sub-12
						1-2061	Sub-33	3，4-diClPh	SO2	Single bond	Sub-13
1-2062	Sub-33	3，4-diClPh	SO2	Single bond	Sub-14
						1-2063	Sub-33	3，4-diClPh	SO2	Single bond	Sub-15
1-2064	Sub-33	3，4-diClPh	SO2	Single bond	Sub-16
						1-2065	Sub-33	3，4-diClPh	S02	Single bond	Sub-17
1-2066	Sub-33	3，4-diClPh	SO2	Single bond	Sub-18
						1-2067	Sub-33	3，4-diClPh	SO2	Single bond	Sub-19
1-2068	Sub-33	3，4-diClPh	SO2	Single bond	Sub-20
						1-2069	Sub-33	3，4-diClPh	SO2	Single bond	Sub-21
1-2070	Sub-33	3，4-diClPh	SO2	Single bond	Sub-22
						1-2071	Sub-33	3，4-diClPh	SO2	Single bond	Sub-23
1-2072	Sub-33	3，4-diClPh	SO2	Single bond	Sub-24
						1-2073	Sub-33	3，4-diClPh	SO2	Single bond	Sub-25
1-2074	Sub-33	3，4-diClPh	SO2	Single bond	Sub-26
						1-2075	Sub-33	3，4-diClPh	SO2	Single bond	Sub-27
1-2076	Sub-33	3，4-diClPh	SO2	Single bond	Sub-28
						1-2077	Sub-33	3，4-diClPh	SO2	Single bond	Sub-29
1-2078	Sub-33	3，4-diClPh	SO2	Single bond	Sub-30
						1-2079	Sub-33	3，4-diClPh	SO2	Single bond	Sub-31
1-2080	Sub-33	3，4-diClPh	SO2	Single bond	Sub-32

Table 1(cont.)

Number of Compounds	R1	R2	A	B	Z
						1-2081	Sub-34	3，4-diClPh	SO2	Single bond	Sub-1
1-2082	Sub-34	3，4-diClPh	SO2	Single bond	Sub-2
						1-2083	Sub-34	3，4-diClPh	SO2	Single bond	Sub-3
1-2084	Sub-34	3，4-diClPh	SO2	Single bond	Sub-4
						1-2085	Sub-34	3，4-diClPh	SO2	Single bond	Sub-5
1-2086	Sub-34	3，4-diClPh	SO2	Single bond	Sub-6
						1-2087	Sub-34	3，4-diClPh	SO2	Single bond	Sub-7
1-2088	Sub-34	3，4-diClPh	SO2	Single bond	Sub-8
						1-2089	Sub-34	3，4-diClPh	SO2	Single bond	Sub-9
1-2090	Sub-34	3，4-diClPh	SO2	Single bond	Sub-10
						1-2091	Sub-34	3，4-diClPh	SO2	Single bond	Sub-11
1-2092	Sub-34	3，4-diClPh	SO2	Single bond	Sub-12
						1-2093	Sub-34	3，4-diClPh	SO2	Single bond	Sub-13
1-2094	Sub-34	3，4-diClPh	SO2	Single bond	Sub-14
						1-2095	Sub-34	3，4-diClPh	SO2	Single bond	Sub-15
1-2096	Sub-34	3，4-diClPh	SO2	Single bond	Sub-16
						1-2097	Sub-34	3，4-diClPh	SO2	Single bond	Sub-17
1-2098	Sub-34	3，4-diClPh	SO2	Single bond	Sub-18
						1-2099	Sub-34	3，4-diClPh	SO2	Single bond	Sub-19
1-2100	Sub-34	3，4-diClPh	SO2	Single bond	Sub-20
						1-2101	Sub-34	3，4-diClPh	SO2	Single bond	Sub-21
1-2102	Sub-34	3，4-diClPh	SO2	Single bond	Sub-22
						1-2103	Sub-34	3，4-diClPh	SO2	Single bond	Sub-23
1-2104	Sub-34	3，4-diClPh	SO2	Single bond	Sub-24
						1-2105	Sub-34	3，4-diClPh	SO2	Single bond	Sub-25
1-2106	Sub-34	3，4-diClPh	SO2	Single bond	Sub-26

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2107	Sub-34	3，4-diClPh	SO2	Single bond	Sub-27
1-2108	Sub-34	3，4-diClPh	SO2	Single bond	Sub-28
						1-2109	Sub-34	3，4-diClPh	SO2	Single bond	Sub-29
1-2110	Sub-34	3，4-diClPh	SO2	Single bond	Sub-30
						1-2111	Sub-34	3，4-diClPh	SO2	Single bond	Sub-31
1-2112	Sub-34	3，4-diClPh	SO2	Single bond	Sub-32
						1-2113	Sub-35	3，4-diClPh	SO2	Single bond	Sub-1
1-2114	Sub-35	3，4-diClPh	SO2	Single bond	Sub-2
						1-2115	Sub-35	3，4-diClPh	SO2	Single bond	Sub-3
1-2116	Sub-35	3，4-diClPh	SO2	Single bond	Sub-4
						1-2117	Sub-35	3，4-diClPh	SO2	Single bond	Sub-5
1-2118	Sub-35	3，4-diClPh	SO2	Single bond	Sub-6
						1-2119	Sub-35	3，4-diClPh	SO2	Single bond	Sub-7
1-2120	Sub-35	3，4-diClPh	SO2	Single bond	Sub-8
						1-2121	Sub-35	3，4-diClPh	SO2	Single bond	Sub-9
1-2122	Sub-35	3，4-diClPh	SO2	Single bond	Sub-10
						1-2123	Sub-35	3，4-diClPh	SO2	Single bond	Sub-11
1-2124	Sub-35	3，4-diClPh	SO2	Single bond	Sub-12
						1-2125	Sub-35	3，4-diClPh	SO2	Single bond	Sub-13
1-2126	Sub-35	3，4-diClPh	SO2	Single bond	Sub-14
						1-2127	Sub-35	3，4-diClPh	SO2	Single bond	Sub-15
1-2128	Sub-35	3，4-diClPh	SO2	Single bond	Sub-16
						1-2129	Sub-35	3，4-diClPh	SO2	Single bond	Sub-17
1-2130	Sub-35	3，4-diClPh	SO2	Single bond	Sub-18
						1-2131	Sub-35	3，4-diClPh	SO2	Single bond	Sub-19
1-2132	Sub-35	3，4-diClPh	SO2	Single bond	Sub-20

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2133	Sub-35	3，4-diClPh	SO2	Single bond	Sub-21
1-2134	Sub-35	3，4-diClPh	SO2	Single bond	Sub-22
						1-2135	Sub-35	3，4-diClPh	SO2	Single bond	Sub-23
1-2136	Sub-35	3，4-diClPh	SO2	Single bond	Sub-24
						1-2137	Sub-35	3，4-diClPh	SO2	Single bond	Sub-25
1-2138	Sub-35	3，4-diClPh	SO2	Single bond	Sub-26
						1-2139	Sub-35	3，4-diClPh	SO2	Single bond	Sub-27
1-2140	Sub-35	3，4-diClPh	SO2	Single bond	Sub-28
						1-2141	Sub-35	3，4-diClPh	SO2	Single bond	Sub-29
1-2142	Sub-35	3，4-diClPh	SO2	Single bond	Sub-30
						1-2143	Sub-35	3，4-diClPh	SO2	Single bond	Sub-31
1-2144	Sub-35	3，4-diClPh	SO2	Single bond	Sub-32
						1-2145	Sub-36	3，4-diClPh	SO2	Single bond	Sub-1
1-2146	Sub-36	3，4-diClPh	SO2	Single bond	Sub-2
						1-2147	Sub-36	3，4-diClPh	SO2	Single bond	Sub-3
1-2148	Sub-36	3，4-diClPh	SO2	Single bond	Sub-4
						1-2149	Sub-36	3，4-diClPh	SO2	Single bond	Sub-5
1-2150	Sub-36	3，4-diClPh	SO2	Single bond	Sub-6
						1-2151	Sub-36	3，4-diClPh	SO2	Single bond	Sub-7
1-2152	Sub-36	3，4-diClPh	SO2	Single bond	Sub-8
						1-2153	Sub-36	3，4-diClPh	SO2	Single bond	Sub-9
1-2154	Sub-36	3，4-diClPh	SO2	Single bond	Sub-10
						1-2155	Sub-36	3，4-diClPh	SO2	Single bond	Sub-11
1-2156	Sub-36	3，4-diClPh	SO2	Single bond	Sub-12
						1-2157	Sub-36	3，4-diClPh	SO2	Single bond	Sub-13
1-2158	Sub-36	3，4-diClPh	SO2	Single bond	Sub-14

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2159	Sub-36	3，4-diClPh	SO2	Single bond	Sub-15
1-2160	Sub-36	3，4-diClPh	SO2	Single bond	Sub-16
						1-2161	Sub-36	3，4-diClPh	SO2	Single bond	Sub-17
1-2162	Sub-36	3，4-diClPh	SO2	Single bond	Sub-18
						1-2163	Sub-36	3，4-diClPh	SO2	Single bond	Sub-19
1-2164	Sub-36	3，4-diClPh	SO2	Single bond	Sub-20
						1-2165	Sub-36	3，4-diClPh	SO2	Single bond	Sub-21
1-2166	Sub-36	3，4-diClPh	SO2	Single bond	Sub-22
						1-2167	Sub-36	3，4-diClPh	SO2	Single bond	Sub-23
1-2168	Sub-36	3，4-diClPh	SO2	Single bond	Sub-24
						1-2169	Sub-36	3，4-diClPh	SO2	Single bond	Sub-25
1-2170	Sub-36	3，4-diClPh	SO2	Single bond	Sub-26
						1-2171	Sub-36	3，4-diClPh	SO2	Single bond	Sub-27
1-2172	Sub-36	3，4-diClPh	SO2	Single bond	Sub-28
						1-2173	Sub-36	3，4-diClPh	SO2	Single bond	Sub-29
1-2174	Sub-36	3，4-diClPh	SO2	Single bond	Sub-30
						1-2175	Sub-36	3，4-diClPh	SO2	Single bond	Sub-31
1-2176	Sub-36	3，4-diClPh	SO2	Single bond	Sub-32
						1-2177	Sub-37	3，4-diClPh	SO2	Single bond	Sub-1
1-2178	Sub-37	3，4-diClPh	SO2	Single bond	Sub-2
						1-2179	Sub-37	3，4-diClPh	SO2	Single bond	Sub-3
1-2180	Sub-37	3，4-diClPh	SO2	Single bond	Sub-4
						1-2181	Sub-37	3，4-diClPh	SO2	Single bond	Sub-5
1-2182	Sub-37	3，4-diClPh	SO2	Single bond	Sub-6
						1-2183	Sub-37	3，4-diClPh	SO2	Single bond	Sub-7
1-2184	Sub-37	3，4-diClPh	SO2	Single bond	Sub-8

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2185	Sub-37	3，4-diClPh	SO2	Single bond	Sub-9
1-2186	Sub-37	3，4-diClPh	SO2	Single bond	Sub-10
						1-2187	Sub-37	3，4-diClPh	SO2	Single bond	Sub-11
1-2188	Sub-37	3，4-diClPh	SO2	Single bond	Sub-12
						1-2189	Sub-37	3，4-diClPh	SO2	Single bond	Sub-13
1-2190	Sub-37	3，4-diClPh	SO2	Single bond	Sub-14
						1-2191	Sub-37	3，4-diClPh	SO2	Single bond	Sub-15
1-2192	Sub-37	3，4-diClPh	SO2	Single bond	Sub-16
						1-2193	Sub-37	3，4-diClPh	SO2	Single bond	Sub-17
1-2194	Sub-37	3，4-diClPh	SO2	Single bond	Sub-18
						1-2195	Sub-37	3，4-diClPh	SO2	Single bond	Sub-19
1-2196	Sub-37	3，4-diClPh	SO2	Single bond	Sub-20
						1-2197	Sub-37	3，4-diClPh	SO2	Single bond	Sub-21
1-2198	Sub-37	3，4-diClPh	SO2	Single bond	Sub-22
						1-2199	Sub-37	3，4-diClPh	SO2	Single bond	Sub-23
1-2200	Sub-37	3，4-diClPh	SO2	Single bond	Sub-24
						1-2201	Sub-37	3，4-diClPh	SO2	Single bond	Sub-25
1-2202	Sub-37	3，4-diClPh	SO2	Single bond	Sub-26
						1-2203	Sub-37	3，4-diClPh	SO2	Single bond	Sub-27
1-2204	Sub-37	3，4-diClPh	SO2	Single bond	Sub-28
						1-2205	Sub-37	3，4-diClPh	SO2	Single bond	Sub-29
1-2206	Sub-37	3，4-diClPh	SO2	Single bond	Sub-30
						1-2207	Sub-37	3，4-diClPh	SO2	Single bond	Sub-31
1-2208	Sub-37	3，4-diClPh	SO2	Single bond	Sub-32
						1-2209	Sub-38	3，4-diClPh	SO2	Single bond	Sub-1
1-2210	Sub-38	3，4-diClPh	SO2	Single bond	Sub-2

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2211	Sub-38	3，4-diClPh	SO2	Single bond	Sub-3
1-2212	Sub-38	3，4-diClPh	SO2	Single bond	Sub-4
						1-2213	Sub-38	3，4-diClPh	SO2	Single bond	Sub-5
1-2214	Sub-38	3，4-diClPh	SO2	Single bond	Sub-6
						1-2215	Sub-38	3，4-diClPh	SO2	Single bond	Sub-7
1-2216	Sub-38	3，4-diClPh	SO2	Single bond	Sub-8
						1-2217	Sub-38	3，4-diClPh	SO2	Single bond	Sub-9
1-2218	Sub-38	3，4-diClPh	SO2	Single bond	Sub-10
						1-2219	Sub-38	3，4-diClPh	SO2	Single bond	Sub-11
1-2220	Sub-38	3，4-diClPh	SO2	Single bond	Sub-12
						1-2221	Sub-38	3，4-diClPh	SO2	Single bond	Sub-13
1-2222	Sub-38	3，4-diClPh	SO2	Single bond	Sub-14
						1-2223	Sub-38	3，4-diClPh	SO2	Single bond	Sub-15
1-2224	Sub-38	3，4-diClPh	SO2	Single bond	Sub-16
						1-2225	Sub-38	3，4-diClPh	SO2	Single bond	Sub-17
1-2226	Sub-38	3，4-diClPh	SO2	Single bond	Sub-18
						1-2227	Sub-38	3，4-diClPh	SO2	Single bond	Sub-19
1-2228	Sub-38	3，4-diClPh	SO2	Single bond	Sub-20
						1-2229	Sub-38	3，4-diClPh	SO2	Single bond	Sub-21
1-2230	Sub-38	3，4-diClPh	SO2	Single bond	Sub-22
						1-2231	Sub-38	3，4-diClPh	SO2	Single bond	Sub-23
1-2232	Sub-38	3，4-diClPh	SO2	Single bond	Sub-24
						1-2233	Sub-38	3，4-diClPh	SO2	Single bond	Sub-25
1-2234	Sub-38	3，4-diClPh	SO2	Single bond	Sub-26
						1-2235	Sub-38	3，4-diClPh	SO2	Single bond	Sub-27
1-2236	Sub-38	3，4-diClPh	SO2	Single bond	Sub-28

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2237	Sub-38	3，4-diClPh	SO2	Single bond	Sub-29
1-2238	Sub-38	3，4-diClPh	SO2	Single bond	Sub-30
						1-2239	Sub-38	3，4-diClPh	S02	Single bond	Sub-31
1-2240	Sub-38	3，4-diClPh	SO2	Single bond	Sub-32
						1-2241	Sub-39	3，4-diClPh	SO2	Single bond	Sub-1
1-2242	Sub-39	3，4-diClPh	SO2	Single bond	Sub-2
						1-2243	Sub-39	3，4-diClPh	SO2	Single bond	Sub-3
1-2244	Sub-39	3，4-diClPh	SO2	Single bond	Sub-4
						1-2245	Sub-39	3，4-diClPh	SO2	Single bond	Sub-5
1-2246	Sub-39	3，4-diClPh	SO2	Single bond	Sub-6
						1-2247	Sub-39	3，4-diClPh	SO2	Single bond	Sub-7
1-2248	Sub-39	3，4-diClPh	SO2	Single bond	Sub-8
						1-2249	Sub-39	3，4-diClPh	SO2	Single bond	Sub-9
1-2250	Sub-39	3，4-diClPh	SO2	Single bond	Sub-10
						1-2251	Sub-39	3，4-diClPh	SO2	Single bond	Sub-11
1-2252	Sub-39	3，4-diClPh	SO2	Single bond	Sub-12
						1-2253	Sub-39	3，4-diClPh	SO2	Single bond	Sub-13
1-2254	Sub-39	3，4-diClPh	SO2	Single bond	Sub-14
						1-2255	Sub-39	3，4-diClPh	SO2	Single bond	Sub-15
1-2256	Sub-39	3，4-diClPh	SO2	Single bond	Sub-16
						1-2257	Sub-39	3，4-diClPh	SO2	Single bond	Sub-17
1-2258	Sub-39	3，4-diClPh	SO2	Single bond	Sub-18
						1-2259	Sub-39	3，4-diClPh	SO2	Single bond	Sub-19
1-2260	Sub-39	3，4-diClPh	SO2	Single bond	Sub-20
						1-2261	Sub-39	3，4-diClPh	SO2	Single bond	Sub-21
1-2262	Sub-39	3，4-diClPh	SO2	Single bond	Sub-22

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2263	Sub-39	3，4-diClPh	SO2	Single bond	Sub-23
1-2264	Sub-39	3，4-diClPh	SO2	Single bond	Sub-24
						1-2265	Sub-39	3，4-diClPh	SO2	Single bond	Sub-25
1-2266	Sub-39	3，4-diClPh	SO2	Single bond	Sub-26
						1-2267	Sub-39	3，4-diClPh	SO2	Single bond	Sub-27
1-2268	Sub-39	3，4-diClPh	SO2	Single bond	Sub-28
						1-2269	Sub-39	3，4-diClPh	SO2	Single bond	Sub-29
1-2270	Sub-39	3，4-diClPh	SO2	Single bond	Sub-30
						1-2271	Sub-39	3，4-diClPh	SO2	Single bond	Sub-31
1-2272	Sub-39	3，4-diClPh	SO2	Single bond	Sub-32
						1-2273	Sub-40	3，4-diClPh	SO2	Single bond	Sub-1
1-2274	Sub-40	3，4-diClPh	SO2	Single bond	Sub-2
						1-2275	Sub-40	3，4-diClPh	SO2	Single bond	Sub-3
1-2276	Sub-40	3，4-diClPh	SO2	Single bond	Sub-4
						1-2277	Sub-40	3，4-diClPh	SO2	Single bond	Sub-5
1-2278	Sub-40	3，4-diClPh	SO2	Single bond	Sub-6
						1-2279	Sub-40	3，4-diClPh	SO2	Single bond	Sub-7
1-2280	Sub-40	3，4-diClPh	SO2	Single bond	Sub-8
						1-2281	Sub-40	3，4-diClPh	SO2	Single bond	Sub-9
1-2282	Sub-40	3，4-diClPh	SO2	Single bond	Sub-10
						1-2283	Sub-40	3，4-diClPh	SO2	Single bond	Sub-11
1-2284	Sub-40	3，4-diClPh	SO2	Single bond	Sub-12
						1-2285	Sub-40	3，4-diClPh	SO2	Single bond	Sub-13
1-2286	Sub-40	3，4-diClPh	SO2	Single bond	Sub-14
						1-2287	Sub-40	3，4-diClPh	SO2	Single bond	Sub-15
1-2288	Sub-40	3，4-diClPh	SO2	Single bond	Sub-16

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2289	Sub-40	3，4-diClPh	SO2	Single bond	Sub-17
1-2290	Sub-40	3，4-diClPh	SO2	Single bond	Sub-18
						1-2291	Sub-40	3，4-diClPh	SO2	Single bond	Sub-19
1-2292	Sub-40	3，4-diClPh	SO2	Single bond	Sub-20
						1-2293	Sub-40	3，4-diClPh	SO2	Single bond	Sub-21
1-2294	Sub-40	3，4-diClPh	SO2	Single bond	Sub-22
						1-2295	Sub-40	3，4-diClPh	SO2	Single bond	Sub-23
1-2296	Sub-40	3，4-diClPh	SO2	Single bond	Sub-24
						1-2297	Sub-40	3，4-diClPh	SO2	Single bond	Sub-25
1-2298	Sub-40	3，4-diClPh	SO2	Single bond	Sub-26
						1-2299	Sub-40	3，4-diClPh	SO2	Single bond	Sub-27
1-2300	Sub-40	3，4-diClPh	SO2	Single bond	Sub-28
						1-2301	Sub-40	3，4-diClPh	SO2	Single bond	Sub-29
1-2302	Sub-40	3，4-diClPh	SO2	Single bond	Sub-30
						1-2303	Sub-40	3，4-diClPh	SO2	Single bond	Sub-31
1-2304	Sub-40	3，4-diClPh	SO2	Single bond	Sub-32
						1-2305	Sub-41	3，4-diClPh	SO2	Single bond	Sub-1
1-2306	Sub-41	3，4-diClPh	SO2	Single bond	Sub-2
						1-2307	Sub-41	3，4-diClPh	SO2	Single bond	Sub-3
1-2308	Sub-41	3，4-diClPh	SO2	Single bond	Sub-4
						1-2309	Sub-41	3，4-diClPh	SO2	Single bond	Sub-5
1-2310	Sub-41	3，4-diClPh	SO2	Single bond	Sub-6
						1-2311	Sub-41	3，4-diClPh	SO2	Single bond	Sub-7
1-2312	Sub-41	3，4-diClPh	SO2	Single bond	Sub-8
						1-2313	Sub-41	3，4-diClPh	SO2	Single bond	Sub-9
1-2314	Sub-41	3，4-diClPh	SO2	Single bond	Sub-10

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2315	Sub-41	3，4-diClPh	SO2	Single bond	Sub-11
1-2316	Sub-41	3，4-diClPh	SO2	Single bond	Sub-12
						1-2317	Sub-41	3，4-diClPh	SO2	Single bond	Sub-13
1-2318	Sub-41	3，4-diClPh	SO2	Single bond	Sub-14
						1-2319	Sub-41	3，4-diClPh	SO2	Single bond	Sub-15
1-2320	Sub-41	3，4-diClPh	SO2	Single bond	Sub-16
						1-2321	Sub-41	3，4-diClPh	SO2	Single bond	Sub-17
1-2322	Sub-41	3，4-diClPh	SO2	Single bond	Sub-18
						1-2323	Sub-41	3，4-diClPh	SO2	Single bond	Sub-19
1-2324	Sub-41	3，4-diClPh	SO2	Single bond	Sub-20
						1-2325	Sub-41	3，4-diClPh	SO2	Single bond	Sub-21
1-2326	Sub-41	3，4-diClPh	SO2	Single bond	Sub-22
						1-2327	Sub-41	3，4-diClPh	SO2	Single bond	Sub-23
1-2328	Sub-41	3，4-diClPh	SO2	Single bond	Sub-24
						1-2329	Sub-41	3，4-diClPh	SO2	Single bond	Sub-25
1-2330	Sub-41	3，4-diClPh	SO2	Single bond	Sub-26
						1-2331	Sub-41	3，4-diClPh	SO2	Single bond	Sub-27
1-2332	Sub-41	3，4-diClPh	SO2	Single bond	Sub-28
						1-2333	Sub-41	3，4-diClPh	SO2	Single bond	Sub-29
1-2334	Sub-41	3，4-diClPh	SO2	Single bond	Sub-30
						1-2335	Sub-41	3，4-diClPh	SO2	Single bond	Sub-31
1-2336	Sub-41	3，4-diClPh	SO2	Single bond	Sub-32
						1-2337	Sub-42	3，4-diClPh	SO2	Single bond	Sub-1
1-2338	Sub-42	3，4-diClPh	SO2	Single bond	Sub-2
						1-2339	Sub-42	3，4-diClPh	SO2	Single bond	Sub-3
1-2340	Sub-42	3，4-diClPh	SO2	Single bond	Sub-4

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2341	Sub-42	3，4-diClPh	SO2	Single bond	Sub-5
1-2342	Sub-42	3，4-diClPh	SO2	Single bond	Sub-6
						1-2343	Sub-42	3，4-diClPh	SO2	Single bond	Sub-7
1-2344	Sub-42	3，4-diClPh	SO2	Single bond	Sub-8
						1-2345	Sub-42	3，4-diClPh	SO2	Single bond	Sub-9
1-2346	Sub-42	3，4-diClPh	SO2	Single bond	Sub-10
						1-2347	Sub-42	3，4-diClPh	SO2	Single bond	Sub-11
1-2348	Sub-42	3，4-diClPh	SO2	Single bond	Sub-12
						1-2349	Sub-42	3，4-diClPh	SO2	Single bond	Sub-13
1-2350	Sub-42	3，4-diClPh	SO2	Single bond	Sub-14
						1-2351	Sub-42	3，4-diClPh	SO2	Single bond	Sub-15
1-2352	Sub-42	3，4-diClPh	SO2	Single bond	Sub-16
						1-2353	Sub-42	3，4-diClPh	SO2	Single bond	Sub-17
1-2354	Sub-42	3，4-diClPh	SO2	Single bond	Sub-18
						1-2355	Sub-42	3，4-diClPh	SO2	Single bond	Sub-19
1-2356	Sub-42	3，4-diClPh	SO2	Single bond	Sub-20
						1-2357	Sub-42	3，4-diClPh	SO2	Single bond	Sub-21
1-2358	Sub-42	3，4-diClPh	SO2	Single bond	Sub-22
						1-2359	Sub-42	3，4-diClPh	SO2	Single bond	Sub-23
1-2360	Sub-42	3，4-diClPh	SO2	Single bond	Sub-24
						1-2361	Sub-42	3，4-diClPh	SO2	Single bond	Sub-25
1-2362	Sub-42	3，4-diClPh	SO2	Single bond	Sub-26
						1-2363	Sub-42	3，4-diClPh	SO2	Single bond	Sub-27
1-2364	Sub-42	3，4-diClPh	SO2	Single bond	Sub-28
						1-2365	Sub-42	3，4-diClPh	SO2	Single bond	Sub-29
1-2366	Sub-42	3，4-diClPh	SO2	Single bond	Sub-30

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2367	Sub-42	3，4-diClPh	SO2	Single bond	Sub-31
1-2368	Sub-42	3，4-diClPh	SO2	Single bond	Sub-32
						1-2369	Sub-43	3，4-diClPh	SO2	Single bond	Sub-1
1-2370	Sub-43	3，4-diClPh	SO2	Single bond	Sub-2
						1-2371	Sub-43	3，4-diClPh	SO2	Single bond	Sub-3
1-2372	Sub-43	3，4-diClPh	SO2	Single bond	Sub-4
						1-2373	Sub-43	3，4-diClPh	SO2	Single bond	Sub-5
1-2374	Sub-43	3，4-diClPh	SO2	Single bond	Sub-6
						1-2375	Sub-43	3，4-diClPh	SO2	Single bond	Sub-7
1-2376	Sub-43	3，4-diClPh	SO2	Single bond	Sub-8
						1-2377	Sub-43	3，4-diClPh	SO2	Single bond	Sub-9
1-2378	Sub-43	3，4-diClPh	SO2	Single bond	Sub-10
						1-2379	Sub-43	3，4-diClPh	SO2	Single bond	Sub-11
1-2380	Sub-43	3，4-diClPh	SO2	Single bond	Sub-12
						1-2381	Sub-43	3，4-diClPh	SO2	Single bond	Sub-13
1-2382	Sub-43	3，4-diClPh	SO2	Single bond	Sub-14
						1-2383	Sub-43	3，4-diClPh	SO2	Single bond	Sub-15
1-2384	Sub-43	3，4-diClPh	SO2	Single bond	Sub-16
						1-2385	Sub-43	3，4-diClPh	SO2	Single bond	Sub-17
1-2386	Sub-43	3，4-diClPh	SO2	Single bond	Sub-18
						1-2387	Sub-43	3，4-diClPh	SO2	Single bond	Sub-19
1-2388	Sub-43	3，4-diClPh	SO2	Single bond	Sub-20
						1-2389	Sub-43	3，4-diClPh	SO2	Single bond	Sub-21
1-2390	Sub-43	3，4-diClPh	SO2	Single bond	Sub-22
						1-2391	Sub-43	3，4-diClPh	SO2	Single bond	Sub-23
1-2392	Sub-43	3，4-diClPh	SO2	Single bond	Sub-24

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2393	Sub-43	3，4-diClPh	SO2	Single bond	Sub-25
1-2394	Sub-43	3，4-diClPh	SO2	Single bond	Sub-26
						1-2395	Sub-43	3，4-diClPh	SO2	Single bond	Sub-27
1-2396	Sub-43	3，4-diClPh	SO2	Single bond	Sub-28
						1-2397	Sub-43	3，4-diClPh	SO2	Single bond	Sub-29
1-2398	Sub-43	3，4-diClPh	SO2	Single bond	Sub-30
						1-2399	Sub-43	3，4-diClPh	SO2	Single bond	Sub-31
1-2400	Sub-43	3，4-diClPh	SO2	Single bond	Sub-32
						1-2401	Sub-44	3，4-diClPh	SO2	Single bond	Sub-1
1-2402	Sub-44	3，4-diClPh	SO2	Single bond	Sub-2
						1-2403	Sub-44	3，4-diClPh	SO2	Single bond	Sub-3
1-2404	Sub-44	3，4-diClPh	SO2	Single bond	Sub-4
						1-2405	Sub-44	3，4-diClPh	SO2	Single bond	Sub-5
1-2406	Sub-44	3，4-diClPh	SO2	Single bond	Sub-6
						1-2407	Sub-44	3，4-diClPh	SO2	Single bond	Sub-7
1-2408	Sub-44	3，4-diClPh	SO2	Single bond	Sub-8
						1-2409	Sub-44	3，4-diClPh	SO2	SheetKey with a key body	Sub-9
1-2410	Sub-44	3，4-diClPh	SO2	Single bond	Sub-10
						1-2411	Sub-44	3，4-diClPh	SO2	Single bond	Sub-11
1-2412	Sub-44	3，4-diClPh	SO2	Single bond	Sub-12
						1-2413	Sub-44	3，4-diClPh	SO2	Single bond	Sub-13
1-2414	Sub-44	3，4-diClPh	SO2	Single bond	Sub-14
						1-2415	Sub-44	3，4-diClPh	SO2	Single bond	Sub-15
1-2416	Sub-44	3，4-diClPh	SO2	Single bond	Sub-16
						1-2417	Sub-44	3，4-diClPh	SO2	Single bond	Sub-17
1-2418	Sub-44	3，4-diClPh	SO2	Single bond	Sub-18

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2419	Sub-44	3，4-diClPh	SO2	Single bond	Sub-19
1-2420	Sub-44	3，4-diClPh	SO2	Single bond	Sub-20
						1-2421	Sub-44	3，4-diClPh	SO2	Single bond	Sub-21
1-2422	Sub-44	3，4-diClPh	SO2	Single bond	Sub-22
						1-2423	Sub-44	3，4-diClPh	SO2	Single bond	Sub-23
1-2424	Sub-44	3，4-diClPh	SO2	Single bond	Sub-24
						1-2425	Sub-44	3，4-diClPh	SO2	Single bond	Sub-25
1-2426	Sub-44	3，4-diClPh	SO2	Single bond	Sub-26
						1-2427	Sub-44	3，4-diClPh	SO2	Single bond	Sub-27
1-2428	Sub-44	3，4-diClPh	SO2	Single bond	Sub-28
						1-2429	Sub-44	3，4-diClPh	SO2	Single bond	Sub-29
1-2430	Sub-44	3，4-diClPh	SO2	Single bond	Sub-30
						1-2431	Sub-44	3，4-diClPh	SO2	Single bond	Sub-31
1-2432	Sub-44	3，4-diClPh	SO2	Single bond	Sub-32
						1-2433	Sub-45	3，4-diClPh	SO2	Single bond	Sub-1
1-2434	Sub-45	3，4-diClPh	SO2	Single bond	Sub-2
						1-2435	Sub-45	3，4-diClPh	SO2	Single bond	Sub-3
1-2436	Sub-45	3，4-diClPh	SO2	Single bond	Sub-4
						1-2437	Sub-45	3，4-diClPh	SO2	Single bond	Sub-5
1-2438	Sub-45	3，4-diClPh	SO2	Single bond	Sub-6
						1-2439	Sub-45	3，4-diClPh	SO2	Single bond	Sub-7
1-2440	Sub-45	3，4-diClPh	SO2	Single bond	Sub-8
						1-2441	Sub-45	3，4-diClPh	SO2	Single bond	Sub-9
1-2442	Sub-45	3，4-diClPh	SO2	Single bond	Sub-10
						1-2443	Sub-45	3，4-diClPh	SO2	Single bond	Sub-11
1-2444	Sub-45	3，4-diClPh	SO2	Single bond	Sub-12

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2445	Sub-45	3，4-diClPh	SO2	Single bond	Sub-13
1-2446	Sub-45	3，4-diClPh	SO2	Single bond	Sub-14
						1-2447	Sub-45	3，4-diClPh	SO2	Single bond	Sub-15
1-2448	Sub-45	3，4-diClPh	SO2	Single bond	Sub-16
						1-2449	Sub-45	3，4-diClPh	SO2	Single bond	Sub-17
1-2450	Sub-45	3，4-diClPh	SO2	Single bond	Sub-18
						1-2451	Sub-45	3，4-diClPh	SO2	Single bond	Sub-19
1-2452	Sub-45	3，4-diClPh	SO2	Single bond	Sub-20
						1-2453	Sub-45	3，4-diClPh	SO2	Single bond	Sub-21
1-2454	Sub-45	3，4-diClPh	SO2	Single bond	Sub-22
						1-2455	Sub-45	3，4-diClPh	SO2	Single bond	Sub-23
1-2456	Sub-45	3，4-diClPh	SO2	Single bond	Sub-24
						1-2457	Sub-45	3，4-diClPh	SO2	Single bond	Sub-25
1-2458	Sub-45	3，4-diClPh	SO2	Single bond	Sub-26
						1-2459	Sub-45	3，4-diClPh	SO2	Single bond	Sub-27
1-2460	Sub-45	3，4-diClPh	SO2	Single bond	Sub-28
						1-2461	Sub-45	3，4-diClPh	SO2	Single bond	Sub-29
1-2462	Sub-45	3，4-diClPh	SO2	Single bond	Sub-30
						1-2463	Sub-45	3，4-diClPh	SO2	Single bond	Sub-31
1-2464	Sub-45	3，4-diClPh	SO2	Single bond	Sub-32
						1-2465	Sub-46	3，4-diClPh	SO2	Single bond	Sub-1
1-2466	Sub-46	3，4-diClPh	SO2	Single bond	Sub-2
						1-2467	Sub-46	3，4-diClPh	SO2	Single bond	Sub-3
1-2468	Sub-46	3，4-diClPh	SO2	Single bond	Sub-4
						1-2469	Sub-46	3，4-diClPh	SO2	Single bond	Sub-5
1-2470	Sub-46	3，4-diClPh	SO2	Single bond	Sub-6

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2471	Sub-46	3，4-diClPh	SO2	Single bond	Sub-7
1-2472	Sub-46	3，4-diClPh	SO2	Single bond	Sub-8
						1-2473	Sub-46	3，4-diClPh	SO2	Single bond	Sub-9
1-2474	Sub-46	3，4-diClPh	SO2	Single bond	Sub-10
						1-2475	Sub-46	3，4-diClPh	SO2	Single bond	Sub-11
1-2476	Sub-46	3，4-diClPh	SO2	Single bond	Sub-12
						1-2477	Sub-46	3，4-diClPh	SO2	Single bond	Sub-13
1-2478	Sub-46	3，4-diClPh	SO2	Single bond	Sub-14
						1-2479	Sub-46	3，4-diClPh	SO2	Single bond	Sub-15
1-2480	Sub-46	3，4-diClPh	SO2	Single bond	Sub-16
						1-2481	Sub-46	3，4-diClPh	SO2	Single bond	Sub-17
1-2482	Sub-46	3，4-diClPh	SO2	Single bond	Sub-18
						1-2483	Sub-46	3，4-diClPh	SO2	Single bond	Sub-19
1-2484	Sub-46	3，4-diClPh	SO2	Single bond	Sub-20
						1-2485	Sub-46	3，4-diClPh	SO2	Single bond	Sub-21
1-2486	Sub-46	3，4-diClPh	SO2	Single bond	Sub-22
						1-2487	Sub-46	3，4-diClPh	SO2	Single bond	Sub-23
1-2488	Sub-46	3，4-diClPh	SO2	Single bond	Sub-24
						1-2489	Sub-46	3，4-diClPh	SO2	Single bond	Sub-25
1-2490	Sub-46	3，4-diClPh	SO2	Single bond	Sub-26
						1-2491	Sub-46	3，4-diClPh	SO2	Single bond	Sub-27
1-2492	Sub-46	3，4-diClPh	SO2	Single bond	Sub-28
						1-2493	Sub-46	3，4-diClPh	SO2	Single bond	Sub-29
1-2494	Sub-46	3，4-diClPh	SO2	Single bond	Sub-30
						1-2495	Sub-46	3，4-diClPh	SO2	Single bond	Sub-31
1-2496	Sub-46	3，4-diClPh	SO2	Single bond	Sub-32

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2497	Sub-47	3，4-diClPh	SO2	Single bond	Sub-1
1-2498	Sub-47	3，4-diClPh	SO2	Single bond	Sub-2
						1-2499	Sub-47	3，4-diClPh	SO2	Single bond	Sub-3
1-2500	Sub-47	3，4-diClPh	SO2	Single bond	Sub-4
						1-2501	Sub-47	3，4-diClPh	SO2	Single bond	Sub-5
1-2502	Sub-47	3，4-diClPh	SO2	Single bond	Sub-6
						1-2503	Sub47	3，4-diClPh	SO2	Single bond	Sub-7
1-2504	Sub-47	3，4-diClPh	SO2	Single bond	Sub-8
						1-2505	Sub-47	3，4-diClPh	SO2	Single bond	Sub-9
1-2506	Sub-47	3，4-diClPh	SO2	Single bond	Sub-10
						1-2507	Sub-47	3，4-diClPh	SO2	Single bond	Sub-11
1-2508	Sub-47	3，4-diClPh	SO2	Single bond	Sub-12
						1-2509	Sub-47	3，4-diClPh	SO2	Single bond	Sub-13
1-2510	Sub-47	3，4-diClPh	SO2	Single bond	Sub-14
						1-2511	Sub-47	3，4-diClPh	SO2	Single bond	Sub-15
1-2512	Sub-47	3，4-diClPh	SO2	Single bond	Sub-16
						1-2513	Sub-47	3，4-diClPh	SO2	Single bond	Sub-17
1-2514	Sub-47	3，4-diClPh	SO2	Single bond	Sub-18
						1-2515	Sub-47	3，4-diClPh	SO2	Single bond	Sub-19
1-2516	Sub-47	3，4-diClPh	SO2	Single bond	Sub-20
						1-2517	Sub-47	3，4-diClPh	SO2	Single bond	Sub-21
1-2518	Sub-47	3，4-diClPh	SO2	Single bond	Sub-22
						1-2519	Sub-47	3，4-diClPh	SO2	Single bond	Sub-23
1-2520	Sub-47	3，4-diClPh	SO2	Single bond	Sub-24
						1-2521	Sub-47	3，4-diClPh	SO2	Single bond	Sub-25
1-2522	Sub-47	3，4-diClPh	SO2	Single bond	Sub-26

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2523	Sub-47	3，4-diClPh	SO2	Single bond	Sub-27
1-2524	Sub-47	3，4-diClPh	SO2	Single bond	Sub-28
						1-2525	Sub-47	3，4-diClPh	SO2	Single bond	Sub-29
1-2526	Sub-47	3，4-diClPh	SO2	Single bond	Sub-30
						1-2527	Sub-47	3，4-diClPh	SO2	Single bond	Sub-31
1-2528	Sub-47	3，4-diClPh	SO2	Single bond	Sub-32
						1-2529	Sub-48	3，4-diClPh	SO2	Single bond	Sub-1
1-2530	Sub-48	3，4-diClPh	SO2	Single bond	Sub-2
						1-2531	Sub-48	3，4-diClPh	SO2	Single bond	Sub-3
1-2532	Sub-48	3，4-diClPh	SO2	Single bond	Sub-4
						1-2533	Sub-48	3，4-diClPh	SO2	Single bond	Sub-5
1-2534	Sub-48	3，4-diClPh	SO2	Single bond	Sub-6
						1-2535	Sub-48	3，4-diClPh	SO2	Single bond	Sub-7
1-2536	Sub-48	3，4-diClPh	SO2	Single bond	Sub-8
						1-2537	Sub-48	3，4-diClPh	SO2	Single bond	Sub-9
1-2538	Sub-48	3，4-diClPh	SO2	Single bond	Sub-10
						1-2539	Sub-48	3，4-diClPh	SO2	Single bond	Sub-11
1-2540	Sub-48	3，4-diClPh	SO2	Single bond	Sub-12
						1-2541	Sub-48	3，4-diClPh	SO2	Single bond	Sub-13
1-2542	Sub-48	3，4-diClPh	SO2	Single bond	Sub-14
						1-2543	Sub-48	3，4-diClPh	SO2	Single bond	Sub-15
1-2544	Sub-48	3，4-diClPh	SO2	Single bond	Sub-16
						1-2545	Sub-48	3，4-diClPh	SO2	Single bond	Sub-17
1-2546	Sub-48	3，4-diClPh	SO2	Single bond	Sub-18
						1-2547	Sub-48	3，4-diClPh	SO2	Single bond	Sub-19
1-2548	Sub-48	3，4-diClPh	SO2	Single bond	Sub-20

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2549	Sub-48	3，4-diClPh	SO2	Single bond	Sub-21
1-2550	Sub-48	3，4-diClPh	SO2	Single bond	Sub-22
						1-2551	Sub-48	3，4-diClPh	SO2	Single bond	Sub-23
1-2552	Sub-48	3，4-diClPh	SO2	Single bond	Sub-24
						1-2553	Sub-48	3，4-diClPh	SO2	Single bond	Sub-25
1-2554	Sub-48	3，4-diClPh	SO2	Single bond	Sub-26
						1-2555	Sub-48	3，4-diClPh	SO2	Single bond	Sub-27
1-2556	Sub-48	3，4-diClPh	SO2	Single bond	Sub-28
						1-2557	Sub-48	3，4-diClPh	SO2	Single bond	Sub-29
1-2558	Sub-48	3，4-diClPh	SO2	Single bond	Sub-30
						1-2559	Sub-48	3，4-diClPh	SO2	Single bond	Sub-31
1-2560	Sub-48	3，4-diClPh	SO2	Single bond	Sub-32
						1-2561	Sub-49	3，4-diClPh	SO2	Single bond	Sub-1
1-2562	Sub-49	3，4-diClPh	SO2	Single bond	Sub-2
						1-2563	Sub-49	3，4-diClPh	SO2	Single bond	Sub-3
1-2564	Sub-49	3，4-diClPh	SO2	Single bond	Sub-4
						1-2565	Sub-49	3，4-diClPh	SO2	Single bond	Sub-5
1-2566	Sub-49	3，4-diClPh	SO2	Single bond	Sub-6
						1-2567	Sub-49	3，4-diClPh	SO2	Single bond	Sub-7
1-2568	Sub-49	3，4-diClPh	SO2	Single bond	Sub-8
						1-2569	Sub-49	3，4-diClPh	SO2	Single bond	Sub-9
1-2570	Sub-49	3，4-diClPh	SO2	Single bond	Sub-10
						1-2571	Sub-49	3，4-diClPh	SO2	Single bond	Sub-11
1-2572	Sub-49	3，4-diClPh	SO2	Single bond	Sub-12
						1-2573	Sub-49	3，4-diClPh	SO2	Single bond	Sub-13
1-2574	Sub-49	3，4-diClPh	SO2	Single bond	Sub-14

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2575	Sub-49	3，4-diClPh	SO2	Single bond	Sub-15
1-2576	Sub-49	3，4-diClPh	SO2	Single bond	Sub-16
						1-2577	Sub-49	3，4-diClPh	SO2	Single bond	Sub-17
1-2578	Sub-49	3，4-diClPh	SO2	Single bond	Sub-18
						1-2579	Sub-49	3，4-diClPh	SO2	Single bond	Sub-19
1-2580	Sub-49	3，4-diClPh	SO2	Single bond	Sub-20
						1-2581	Sub-49	3，4-diClPh	SO2	Single bond	Sub-21
1-2582	Sub-49	3，4-diClPh	SO2	Single bond	Sub-22
						1-2583	Sub-49	3，4-diClPh	SO2	Single bond	Sub-23
1-2584	Sub-49	3，4-diClPh	SO2	Single bond	Sub-24
						1-2585	Sub-49	3，4-diClPh	SO2	Single bond	Sub-25
1-2586	Sub-49	3，4-diClPh	SO2	Single bond	Sub-26
						1-2587	Sub-49	3，4-diClPh	SO2	Single bond	Sub-27
1-2588	Sub-49	3，4-diClPh	SO2	Single bond	Sub-28
						1-2589	Sub-49	3，4-diClPh	SO2	Single bond	Sub-29
1-2590	Sub-49	3，4-diClPh	SO2	Single bond	Sub-30
						1-2591	Sub-49	3，4-diClPh	SO2	Single bond	Sub-31
1-2592	Sub-49	3，4-diClPh	SO2	Single bond	Sub-32
						1-2593	Sub-50	3，4-diClPh	SO2	Single bond	Sub-1
1-2594	Sub-50	3，4-diClPh	SO2	Single bond	Sub-2
						1-2595	Sub-50	3，4-diClPh	SO2	Single bond	Sub-3
1-2596	Sub-50	3，4-diClPh	SO2	Single bond	Sub-4
						1-2597	Sub-50	3，4-diClPh	SO2	Single bond	Sub-5
1-2598	Sub-50	3，4-diClPh	SO2	Single bond	Sub-6
						1-2599	Sub-50	3，4-diClPh	SO2	Single bond	Sub-7
1-2600	Sub-50	3，4-diClPh	SO2	Single bond	Sub-8

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2601	Sub-50	3，4-diClPh	SO2	Single bond	Sub-9
1-2602	Sub-50	3，4-diClPh	SO2	Single bond	Sub-10
						1-2603	Sub-50	3，4-diClPh	SO2	Single bond	Sub-11
1-2604	Sub-50	3，4-diClPh	SO2	Single bond	Sub-12
						1-2605	Sub-50	3，4-diClPh	SO2	Single bond	Sub-13
1-2606	Sub-50	3，4-diClPh	SO2	Single bond	Sub-14
						1-2607	Sub-50	3，4-diClPh	SO2	Single bond	Sub-15
1-2608	Sub-50	3，4-diClPh	SO2	Single bond	Sub-16
						1-2609	Sub-50	3，4-diClPh	SO2	Single bond	Sub-17
1-2610	Sub-50	3，4-diClPh	SO2	Single bond	Sub-18
						1-2611	Sub-50	3，4-diClPh	SO2	Single bond	Sub-19
1-2612	Sub-50	3，4-diClPh	SO2	Single bond	Sub-20
						1-2613	Sub-50	3，4-diClPh	SO2	Single bond	Sub-21
1-2614	Sub-50	3，4-diClPh	SO2	Single bond	Sub-22
						1-2615	Sub-50	3，4-diClPh	SO2	Single bond	Sub-23
1-2616	Sub-50	3，4-diClPh	SO2	Single bond	Sub-24
						1-2617	Sub-50	3，4-diClPh	SO2	Single bond	Sub-25
1-2618	Sub-50	3，4-diClPh	SO2	Single bond	Sub-26
						1-2619	Sub-50	3，4-diClPh	SO2	Single bond	Sub-27
1-2620	Sub-50	3，4-diClPh	SO2	Single bond	Sub-28
						1-2621	Sub-50	3，4-diClPh	SO2	Single bond	Sub-29
1-2622	Sub-50	3，4-diClPh	SO2	Single bond	Sub-30
						1-2623	Sub-50	3，4-diClPh	SO2	Single bond	Sub-31
1-2624	Sub-50	3，4-diClPh	SO2	Single bond	Sub-32
						1-2625	Sub-51	3，4-diClPh	SO2	Single bond	Sub-1
1-2626	Sub-51	3，4-diClPh	SO2	Single bond	Sub-2

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2627	Sub-51	3，4-diClPh	SO2	Single bond	Sub-3
1-2628	Sub-51	3，4-diClPh	SO2	Single bond	Sub-4
						1-2629	Sub-51	3，4-diClPh	SO2	Single bond	Sub-5
1-2630	Sub-51	3，4-diClPh	SO2	Single bond	Sub-6
						1-2631	Sub-51	3，4-diClPh	SO2	Single bond	Sub-7
1-2632	Sub-51	3，4-diClPh	SO2	Single bond	Sub-8
						1-2633	Sub-51	3，4-diClPh	SO2	Single bond	Sub-9
1-2634	Sub-51	3，4-diClPh	SO2	Single bond	Sub-10
						1-2635	Sub-51	3，4-diClPh	SO2	Single bond	Sub-11
1-2636	Sub-51	3，4-diClPh	SO2	Single bond	Sub-12
						1-2637	Sub-51	3，4-diClPh	SO2	Single bond	Sub-13
1-2638	Sub-51	3，4-diClPh	SO2	Single bond	Sub-14
						1-2639	Sub-51	3，4-diClPh	SO2	Single bond	Sub-15
1-2640	Sub-51	3，4-diClPh	SO2	Single bond	Sub-16
						1-2641	Sub-51	3，4-diClPh	SO2	Single bond	Sub-17
1-2642	Sub-51	3，4-diClPh	SO2	Single bond	Sub-18
						1-2643	Sub-51	3，4-diClPh	SO2	Single bond	Sub-19
1-2644	Sub-51	3，4-diClPh	SO2	Single bond	Sub-20
						1-2645	Sub-51	3，4-diClPh	SO2	Single bond	Sub-21
1-2646	Sub-51	3，4-diClPh	SO2	Single bond	Sub-22
						1-2647	Sub-51	3，4-diClPh	SO2	Single bond	Sub-23
1-2648	Sub-51	3，4-diClPh	SO2	Single bond	Sub-24
						1-2649	Sub-51	3，4-diClPh	SO2	Single bond	Sub-25
1-2650	Sub-51	3，4-diClPh	SO2	Single bond	Sub-26
						1-2651	Sub-51	3，4-diClPh	SO2	Single bond	Sub-27
1-2652	Sub-51	3，4-diClPh	SO2	Single bond	Sub-28

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2653	Sub-51	3，4-diClPh	SO2	Single bond	Sub-29
1-2654	Sub-51	3，4-diClPh	SO2	Single bond	Sub-30
						1-2655	Sub-51	3，4-diClPh	SO2	Single bond	Sub-31
1-2656	Sub-51	3，4-diClPh	SO2	Single bond	Sub-32
						1-2657	Sub-52	3，4-diClPh	SO2	Single bond	Sub-1
1-2658	Sub-52	3，4-diClPh	SO2	Single bond	Sub-2
						1-2659	Sub-52	3，4-diClPh	SO2	Single bond	Sub-3
1-2660	Sub-52	3，4-diClPh	SO2	Single bond	Sub-4
						1-2661	Sub-52	3，4-diClPh	SO2	Single bond	Sub-5
1-2662	Sub-52	3，4-diClPh	SO2	Single bond	Sub-6
						1-2663	Sub-52	3，4-diClPh	SO2	Single bond	Sub-7
1-2664	Sub-52	3，4-diClPh	SO2	Single bond	Sub-8
						1-2665	Sub-52	3，4-diClPh	SO2	Single bond	Sub-9
1-2666	Sub-52	3，4-diClPh	SO2	Single bond	Sub-10
						1-2667	Sub-52	3，4-diClPh	SO2	Single bond	Sub-11
1-2668	Sub-52	3，4-diClPh	SO2	Single bond	Sub-12
						1-2669	Sub-52	3，4-diClPh	SO2	Single bond	Sub-13
1-2670	Sub-52	3，4-diClPh	SO2	Single bond	Sub-14
						1-2671	Sub-52	3，4-diClPh	SO2	Single bond	Sub-15
1-2672	Sub-52	3，4-diClPh	SO2	Single bond	Sub-16
						1-2673	Sub-52	3，4-diClPh	SO2	Single bond	Sub-17
1-2674	Sub-52	3，4-diClPh	SO2	Single bond	Sub-18
						1-2675	Sub-52	3，4-diClPh	SO2	Single bond	Sub-19
1-2676	Sub-52	3，4-diClPh	SO2	Single bond	Sub-20
						1-2677	Sub-52	3，4-diClPh	SO2	Single bond	Sub-21
1-2678	Sub-52	3，4-diClPh	SO2	Single bond	Sub-22

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2679	Sub-52	3，4-diClPh	SO2	Single bond	Sub-23
1-2680	Sub-52	3，4-diClPh	SO2	Single bond	Sub-24
						1-2681	Sub-52	3，4-diClPh	SO2	Single bond	Sub-25
1-2682	Sub-52	3，4-diClPh	SO2	Single bond	Sub-26
						1-2683	Sub-52	3，4-diClPh	SO2	Single bond	Sub-27
1-2684	Sub-52	3，4-diClPh	SO2	Single bond	Sub-28
						1-2685	Sub-52	3，4-diClPh	SO2	Single bond	Sub-29
1-2686	Sub-52	3，4-diClPh	SO2	Single bond	Sub-30
						1-2687	Sub-52	3，4-diClPh	SO2	Single bond	Sub-31
1-2688	Sub-52	3，4-diClPh	SO2	Single bond	Sub-32
						1-2689	Sub-53	3，4-diClPh	SO2	Single bond	Sub-1
1-2690	Sub-53	3，4-diClPh	SO2	Single bond	Sub-2
						1-2691	Sub-53	3，4-diClPh	SO2	Single bond	Sub-3
1-2692	Sub-53	3，4-diClPh	SO2	Single bond	Sub-4
						1-2693	Sub-53	3，4-diClPh	SO2	Single bond	Sub-5
1-2694	Sub-53	3，4-diClPh	SO2	Single bond	Sub-6
						1-2695	Sub-53	3，4-diClPh	SO2	Single bond	Sub-7
1-2696	Sub-53	3，4-diClPh	SO2	Single bond	Sub-8
						1-2697	Sub-53	3，4-diClPh	SO2	Single bond	Sub-9
1-2698	Sub-53	3，4-diClPh	SO2	Single bond	Sub-10
						1-2699	Sub-53	3，4-diClPh	SO2	Single bond	Sub-11
1-2700	Sub-53	3，4-diClPh	SO2	Single bond	Sub-12
						1-2701	Sub-53	3，4-diClPh	SO2	Single bond	Sub-13
1-2702	Sub-53	3，4-diClPh	SO2	Single bond	Sub-14
						1-2703	Sub-53	3，4-diClPh	SO2	Single bond	Sub-15
1-2704	Sub-53	3，4-diClPh	SO2	Single bond	Sub-16

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2705	Sub-53	3，4-diClPh	SO2	Single bond	Sub-17
1-2706	Sub-53	3，4-diClPh	SO2	Single bond	Sub-18
						1-2707	Sub-53	3，4-diClPh	SO2	Single bond	Sub-19
1-2708	Sub-53	3，4-diClPh	SO2	Single bond	Sub-20
						1-2709	Sub-53	3，4-diClPh	SO2	Single bond	Sub-21
1-2710	Sub-53	3，4-diClPh	SO2	Single bond	Sub-22
						1-2711	Sub-53	3，4-diClPh	SO2	Single bond	Sub-23
1-2712	Sub-53	3，4-diClPh	SO2	Single bond	Sub-24
						1-2713	Sub-53	3，4-diClPh	SO2	Single bond	Sub-25
1-2714	Sub-53	3，4-diClPh	SO2	Single bond	Sub-26
						1-2715	Sub-53	3，4-diClPh	SO2	Single bond	Sub-27
1-2716	Sub-53	3，4-diClPh	SO2	Single bond	Sub-28
						1-2717	Sub-53	3，4-diClPh	SO2	Single bond	Sub-29
1-2718	Sub-53	3，4-diClPh	SO2	Single bond	Sub-30
						1-2719	Sub-53	3，4-diClPh	SO2	Single bond	Sub-31
1-2720	Sub-53	3，4-diClPh	SO2	Single bond	Sub-32
						1-2721	Sub-54	3，4-diClPh	SO2	Single bond	Sub-1
1-2722	Sub-54	3，4-diClPh	SO2	Single bond	Sub-2
						1-2723	Sub-54	3，4-diClPh	SO2	Single bond	Sub-3
1-2724	Sub-54	3，4-diClPh	SO2	Single bond	Sub-4
						1-2725	Sub-54	3，4-diClPh	SO2	Single bond	Sub-5
1-2726	Sub-54	3，4-diClPh	SO2	Single bond	Sub-6
						1-2727	Sub-54	3，4-diClPh	SO2	Single bond	Sub-7
1-2728	Sub-54	3，4-diClPh	SO2	Single bond	Sub-8
						1-2729	Sub-54	3，4-diClPh	SO2	Single bond	Sub-9
1-2730	Sub-54	3，4-diClPh	SO2	Single bond	Sub-10

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2731	Sub-54	3，4-diClPh	SO2	Single bond	Sub-11
1-2732	Sub-54	3，4-diClPh	SO2	Single bond	Sub-12
						1-2733	Sub-54	3，4-diClPh	SO2	Single bond	Sub-13
1-2734	Sub-54	3，4-diClPh	SO2	Single bond	Sub-14
						1-2735	Sub-54	3，4-diClPh	SO2	Single bond	Sub-15
1-2736	Sub-54	3，4-diClPh	SO2	Single bond	Sub-16
						1-2737	Sub-54	3，4-diClPh	SO2	Single bond	Sub-17
1-2738	Sub-54	3，4-diClPh	SO2	Single bond	Sub-18
						1-2739	Sub-54	3，4-diClPh	SO2	Single bond	Sub-19
1-2740	Sub-54	3，4-diClPh	SO2	Single bond	Sub-20
						1-2741	Sub-54	3，4-diClPh	SO2	Single bond	Sub-21
1-2742	Sub-54	3，4-diClPh	SO2	Single bond	Sub-22
						1-2743	Sub-54	3，4-diClPh	SO2	Single bond	Sub-23
1-2744	Sub-54	3，4-diClPh	SO2	Single bond	Sub-24
						1-2745	Sub-54	3，4-diClPh	SO2	Single bond	Sub-25
1-2746	Sub-54	3，4-diClPh	SO2	Single bond	Sub-26
						1-2747	Sub-54	3，4-diClPh	SO2	Single bond	Sub-27
1-2748	Sub-54	3，4-diClPh	SO2	Single bond	Sub-28
						1-2749	Sub-54	3，4-diClPh	SO2	Single bond	Sub-29
1-2750	Sub-54	3，4-diClPh	SO2	Single bond	Sub-30
						1-2751	Sub-54	3，4-diClPh	SO2	Single bond	Sub-31
1-2752	Sub-54	3，4-diClPh	SO2	Single bond	Sub-32
						1-2753	Sub-55	3，4-diClPh	SO2	Single bond	Sub-1
1-2754	Sub-55	3，4-diClPh	SO2	Single bond	Sub-2
						1-2755	Sub-55	3，4-diClPh	SO2	Single bond	Sub-3
1-2756	Sub-55	3，4-diClPh	SO2	Single bond	Sub-4

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2757	Sub-55	3，4-diClPh	SO2	Single bond	Sub-5
1-2758	Sub-55	3，4-diClPh	SO2	Single bond	Sub-6
						1-2759	Sub-55	3，4-diClPh	SO2	Single bond	Sub-7
1-2760	Sub-55	3，4-diClPh	SO2	Single bond	Sub-8
						1-2761	Sub-55	3，4-diClPh	SO2	Single bond	Sub-9
1-2762	Sub-55	3，4-diClPh	SO2	Single bond	Sub-10
						1-2763	Sub-55	3，4-diClPh	SO2	Single bond	Sub-11
1-2764	Sub-55	3，4-diClPh	SO2	Single bond	Sub-12
						1-2765	Sub-55	3，4-diClPh	SO2	Single bond	Sub-13
1-2766	Sub-55	3，4-diClPh	SO2	Single bond	Sub-14
						1-2767	Sub-55	3，4-diClPh	SO2	Single bond	Sub-15
1-2768	Sub-55	3，4-diC1Ph	SO2	Single bond	Sub-16
						1-2769	Sub-55	3，4-diClPh	SO2	Single bond	Sub-17
1-2770	Sub-55	3，4-diClPh	SO2	Single bond	Sub-18
						1-2771	Sub-55	3，4-diClPh	SO2	Single bond	Sub-19
1-2772	Sub-55	3，4-diClPh	SO2	Single bond	Sub-20
						1-2773	Sub-55	3，4-diClPh	SO2	Single bond	Sub-21
l-2774	Sub-55	3，4-diClPh	SO2	Single bond	Sub-22
						1-2775	Sub-55	3，4-diClPh	SO2	Single bond	Sub-23
1-2776	Sub-55	3，4-diClPh	SO2	Single bond	Sub-24
						1-2777	Sub-55	3，4-diClPh	SO2	Single bond	Sub-25
1-2778	Sub-55	3，4-diClPh	SO2	Single bond	Sub-26
						1-2779	Sub-55	3，4-diClPh	SO2	Single bond	Sub-27
1-2780	Sub-55	3，4-diClPh	SO2	Single bond	Sub-28
						1-2781	Sub-55	3，4-diClPh	SO2	Single bond	Sub-29
1-2782	Sub-55	3，4-diClPh	SO2	Single bond	Sub-30

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2783	Sub-55	3，4-diClPh	SO2	Single bond	Sub-31
1-2784	Sub-55	3，4-diClPh	SO2	Single bond	Sub-32
						1-2785	Sub-56	3，4-diClPh	SO2	Single bond	Sub-1
1-2786	Sub-56	3，4-diClPh	SO2	Single bond	Sub-2
						1-2787	Sub-56	3，4-diClPh	SO2	Single bond	Sub-3
1-2788	Sub-56	3，4-diClPh	SO2	Single bond	Sub-4
						1-2789	Sub-56	3，4-diClPh	SO2	Single bond	Sub-5
1-2790	Sub-56	3，4-diClPh	SO2	Single bond	Sub-6
						1-2791	Sub-56	3，4-diClPh	SO2	Single bond	Sub-7
1-2792	Sub-56	3，4-diClPh	SO2	Single bond	Sub-8
						1-2793	Sub-56	3，4-diClPh	SO2	Single bond	Sub-9
1-2794	Sub-56	3，4-diClPh	SO2	Single bond	Sub-10
						1-2795	Sub-56	3，4-diClPh	SO2	Single bond	Sub-11
1-2796	Sub-56	3，4-diClPh	SO2	Single bond	Sub-12
						1-2797	Sub-56	3，4-diClPh	SO2	Single bond	Sub-13
1-2798	Sub-56	3，4-diClPh	SO2	Single bond	Sub-14
						1-2799	Sub-56	3，4-diClPh	SO2	Single bond	Sub-15
1-2800	Sub-56	3，4-diClPh	SO2	Single bond	Sub-16
						1-2801	Sub-56	3，4-diClPh	SO2	Single bond	Sub-17
1-2802	Sub-56	3，4-diClPh	SO2	Single bond	Sub-18
						1-2803	Sub-56	3，4-diClPh	SO2	Single bond	Sub-19
1-2804	Sub-56	3，4-diClPh	SO2	Single bond	Sub-20
						1-2805	Sub-56	3，4-diClPh	SO2	Single bond	Sub-21
1-2806	Sub-56	3，4-diClPh	SO2	Single bond	Sub-22
						1-2807	Sub-56	3，4-diClPh	SO2	Single bond	Sub-23
1-2808	Sub-56	3，4-diClPh	SO2	Single bond	Sub-24

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2809	Sub-56	3，4-diClPh	SO2	Single bond	Sub-25
1-2810	Sub-56	3，4-diClPh	SO2	Single bond	Sub-26
						1-2811	Sub-56	3，4-diClPh	SO2	Single bond	Sub-27
1-2812	Sub-56	3，4-diClPh	SO2	Single bond	Sub-28
						1-2813	Sub-56	3，4-diClPh	SO2	Single bond	Sub-29
1-2814	Sub-56	3，4-diClPh	SO2	Single bond	Sub-30
						1-2815	Sub-56	3，4-diClPh	SO2	Single bond	Sub-31
1-2816	Sub-56	3，4-diClPh	SO2	Single bond	Sub-32
						1-2817	Sub-57	3，4-diClPh	SO2	Single bond	Sub-1
1-2818	Sub-57	3，4-diClPh	SO2	Single bond	Sub-2
						1-2819	Sub-57	3，4-diClPh	SO2	Single bond	Sub-3
1-2820	Sub-57	3，4-diClPh	SO2	Single bond	Sub-4
						1-2821	Sub-57	3，4-diClPh	SO2	Single bond	Sub-5
1-2822	Sub-57	3，4-diClPh	SO2	Single bond	Sub-6
						1-2823	Sub-57	3，4-diClPh	SO2	Single bond	Sub-7
1-2824	Sub-57	3，4-diClPh	SO2	Single bond	Sub-8
						1-2825	Sub-57	3，4-diClPh	SO2	Single bond	Sub-9
1-2826	Sub-57	3，4-diClPh	SO2	Single bond	Sub-10
						1-2827	Sub-57	3，4-diClPh	SO2	Single bond	Sub-11
1-2828	Sub-57	3，4-diClPh	SO2	Single bond	Sub-12
						1-2829	Sub-57	3，4-diClPh	SO2	Single bond	Sub-13
1-2830	Sub-57	3，4-diClPh	SO2	Single bond	Sub-14
						1-2831	Sub-57	3，4-diClPh	SO2	Single bond	Sub-15
1-2832	Sub-57	3，4-diClPh	SO2	Single bond	Sub-16
						1-2833	Sub-57	3，4-diClPh	SO2	Single bond	Sub-17
1-2834	Sub-57	3，4-diClPh	SO2	Single bond	Sub-18

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2835	Sub-57	3，4-diClPh	SO2	Single bond	Sub-19
1-2836	Sub-57	3，4-diClPh	SO2	Single bond	Sub-20
						1-2837	Sub-57	3，4-diClPh	SO2	Single bond	Sub-21
1-2838	Sub-57	3，4-diClPh	SO2	Single bond	Sub-22
						1-2839	Sub-57	3，4-diClPh	SO2	Single bond	Sub-23
1-2840	Sub-57	3，4-diClPh	SO2	Single bond	Sub-24
						1-2841	Sub-57	3，4-diClPh	SO2	Single bond	Sub-25
1-2842	Sub-57	3，4-diClPh	SO2	Single bond	Sub-26
						1-2843	Sub-57	3，4-diClPh	SO2	Single bond	Sub-27
1-2844	Sub-57	3，4-diClPh	SO2	Single bond	Sub-28
						1-2845	Sub-57	3，4-diClPh	SO2	Single bond	Sub-29
1-2846	Sub-57	3，4-diClPh	SO2	Single bond	Sub-30
						1-2847	Sub-57	3，4-diClPh	SO2	Single bond	Sub-31
1-2848	Sub-57	3，4-diClPh	SO2	Single bond	Sub-32
						1-2849	Sub-58	3，4-diClPh	SO2	Single bond	Sub-1
1-2850	Sub-58	3，4-diClPh	SO2	Single bond	Sub-2
						1-2851	Sub-58	3，4-diClPh	SO2	Single bond	Sub-3
1-2852	Sub-58	3，4-diClPh	SO2	Single bond	Sub-4
						1-2853	Sub-58	3，4-diClPh	SO2	Single bond	Sub-5
1-2854	Sub-58	3，4-diClPh	SO2	Single bond	Sub-6
						1-2855	Sub-58	3，4-diClPh	SO2	Single bond	Sub-7
1-2856	Sub-58	3，4-diClPh	SO2	Single bond	Sub-8
						1-2857	Sub-58	3，4-diClPh	SO2	Single bond	Sub-9
1-2858	Sub-58	3，4-diClPh	SO2	Single bond	Sub-10
						1-2859	Sub-58	3，4-diClPh	SO2	Single bond	Sub-11
1-2860	Sub-58	3，4-diClPh	SO2	Single bond	Sub-12

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2861	Sub-58	3，4-diClPh	SO2	Single bond	Sub-13
1-2862	Sub-58	3，4-diClPh	SO2	Single bond	Sub-14
						1-2863	Sub-58	3，4-diClPh	SO2	Single bond	Sub-15
1-2864	Sub-58	3，4-diClPh	SO2	Single bond	Sub-16
						1-2865	Sub-58	3，4-diClPh	SO2	Single bond	Sub-17
1-2866	Sub-58	3，4-diClPh	SO2	Single bond	Sub-18
						1-2867	Sub-58	3，4-diClPh	SO2	Single bond	Sub-19
1-2868	Sub-58	3，4-diClPh	SO2	Single bond	Sub-20
						1-2869	Sub-58	3，4-diClPh	SO2	Single bond	Sub-21
1-2870	Sub-58	3，4-diClPh	SO2	Single bond	Sub-22
						1-2871	Sub-58	3，4-diClPh	SO2	Single bond	Sub-23
1-2872	Sub-58	3，4-diClPh	SO2	Single bond	Sub-24
						1-2873	Sub-58	3，4-diClPh	SO2	Single bond	Sub-25
1-2874	Sub-58	3，4-diClPh	SO2	Single bond	Sub-26
						1-2875	Sub-58	3，4-diClPh	SO2	Single bond	Sub-27
1-2876	Sub-58	3，4-diClPh	SO2	Single bond	Sub-28
						1-2877	Sub-58	3，4-diClPh	SO2	Single bond	Sub-29
1-2878	Sub-58	3，4-diClPh	SO2	Single bond	Sub-30
						1-2879	Sub-58	3，4-diClPh	SO2	Single bond	Sub-31
1-2880	Sub-58	3，4-diClPh	SO2	Single bond	Sub-32
						1-2881	Sub-59	3，4-diClPh	SO2	Single bond	Sub-1
1-2882	Sub-59	3，4-diClPh	SO2	Single bond	Sub-2
						1-2883	Sub-59	3，4-diClPh	SO2	Single bond	Sub-3
1-2884	Sub-59	3，4-diClPh	SO2	Single bond	Sub-4
						1-2885	Sub-59	3，4-diClPh	SO2	Single bond	Sub-5
1-2886	Sub-59	3，4-diClPh	SO2	Single bond	Sub-6

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2887	Sub-59	3，4-diClPh	SO2	Single bond	Sub-7
1-2888	Sub-59	3，4-diClPh	SO2	Single bond	Sub-8
						1-2889	Sub-59	3，4-diClPh	SO2	Single bond	Sub-9
1-2890	Sub-59	3，4-diClPh	SO2	Single bond	Sub-10
						1-2891	Sub-59	3，4-diClPh	SO2	Single bond	Sub-11
1-2892	Sub-59	3，4-diClPh	SO2	Single bond	Sub-12
						1-2893	Sub-59	3，4-diClPh	SO2	Single bond	Sub-13
1-2894	Sub-59	3，4-diClPh	SO2	Single bond	Sub-14
						1-2895	Sub-59	3，4-diClPh	SO2	Single bond	Sub-15
1-2896	Sub-59	3，4-diClPh	SO2	Single bond	Sub-16
						1-2897	Sub-59	3，4-diClPh	SO2	Single bond	Sub-17
1-2898	Sub-59	3，4-diClPh	SO2	Single bond	Sub-18
						1-2899	Sub-59	3，4-diClPh	SO2	Single bond	Sub-19
1-2900	Sub-59	3，4-diClPh	SO2	Single bond	Sub-20
						1-2901	Sub-59	3，4-diClPh	SO2	Single bond	Sub-21
1-2902	Sub-59	3，4-diClPh	SO2	Single bond	Sub-22
						1-2903	Sub-59	3，4-diClPh	SO2	Single bond	Sub-23
1-2904	Sub-59	3，4-diClPh	SO2	Single bond	Sub-24
						1-2905	Sub-59	3，4-diClPh	SO2	Single bond	Sub-25
1-2906	Sub-59	3，4-diClPh	SO2	Single bond	Sub-26
						1-2907	Sub-59	3，4-diClPh	SO2	Single bond	Sub-27
1-2908	Sub-59	3，4-diClPh	SO2	Single bond	Sub-28
						1-2909	Sub-59	3，4-diClPh	SO2	Single bond	Sub-29
1-2910	Sub-59	3，4-diClPh	SO2	Single bond	Sub-30
						1-2911	Sub-59	3，4-diClPh	SO2	Single bond	Sub-31
1-2912	Sub-59	3，4-diClPh	SO2	Single bond	Sub-32

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2913	Sub-60	3，4-diClPh	SO2	Single bond	Sub-1
1-2914	Sub-60	3，4-diClPh	SO2	Single bond	Sub-2
						1-2915	Sub-60	3，4-diClPh	SO2	Single bond	Sub-3
1-2916	Sub-60	3，4-diClPh	SO2	Single bond	Sub-4
						1-2917	Sub-60	3，4-diClPh	SO2	Single bond	Sub-5
1-2918	Sub-60	3，4-diClPh	SO2	Single bond	Sub-6
						1-2919	Sub-60	3，4-diClPh	SO2	Single bond	Sub-7
1-2920	Sub-60	3，4-diClPh	SO2	Single bond	Sub-8
						1-2921	Sub-60	3，4-diClPh	SO2	Single bond	Sub-9
1-2922	Sub-60	3，4-diClPh	SO2	Single bond	Sub-10
						1-2923	Sub-60	3，4-diClPh	SO2	Single bond	Sub-11
1-2924	Sub-60	3，4-diClPh	SO2	Single bond	Sub-12
						1-2925	Sub-60	3，4-diClPh	SO2	Single bond	Sub-13
1-2926	Sub-60	3，4-diClPh	SO2	Single bond	Sub-14
						1-2927	Sub-60	3，4-diClPh	SO2	Single bond	Sub-15
1-2928	Sub-60	3，4-diClPh	SO2	Single bond	Sub-16
						1-2929	Sub-60	3，4-diClPh	SO2	Single bond	Sub-17
1-2930	Sub-60	3，4-diClPh	SO2	Single bond	Sub-18
						1-2931	Sub-60	3，4-diClPh	SO2	Single bond	Sub-19
1-2932	Sub-60	3，4-diClPh	SO2	Single bond	Sub-20
						1-2933	Sub-60	3，4-diClPh	SO2	Single bond	Sub-21
1-2934	Sub-60	3，4-diClPh	SO2	Single bond	Sub-22
						1-2935	Sub-60	3，4-diClPh	SO2	Single bond	Sub-23
1-2936	Sub-60	3，4-diClPh	SO2	Single bond	Sub-24
						1-2937	Sub-60	3，4-diClPh	SO2	Single bond	Sub-25
1-2938	Sub-60	3，4-diClPh	SO2	Single bond	Sub-26

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2939	Sub-60	3，4-diClPh	SO2	Single bond	Sub-27
1-2940	Sub-60	3，4-diClPh	SO2	Single bond	Sub-28
						1-2941	Sub-60	3，4-diClPh	SO2	Single bond	Sub-29
1-2942	Sub-60	3，4-diClPh	SO2	Single bond	Sub-30
						1-2943	Sub-60	3，4-diClPh	SO2	Single bond	Sub-31
1-2944	Sub-60	3，4-diClPh	SO2	Single bond	Sub-32
						1-2945	Sub-61	3，4-diClPh	SO2	Single bond	Sub-1
1-2946	Sub-61	3，4-diClPh	SO2	Single bond	Sub-2
						1-2947	Sub-61	3，4-diClPh	SO2	Single bond	Sub-3
1-2948	Sub-61	3，4-diClPh	SO2	Single bond	Sub-4
						1-2949	Sub-61	3，4-diClPh	SO2	Single bond	Sub-5
1-2950	Sub-61	3，4-diClPh	SO2	Single bond	Sub-6
						1-2951	Sub-61	3，4-diClPh	SO2	Single bond	Sub-7
1-2952	Sub-61	3，4-diClPh	SO2	Single bond	Sub-8
						1-2953	Sub-61	3，4-diClPh	SO2	Single bond	Sub-9
1-2954	Sub-61	3，4-diClPh	SO2	Single bond	Sub-10
						1-2955	Sub-61	3，4-diClPh	SO2	Single bond	Sub-11
1-2956	Sub-61	3，4-diClPh	SO2	Single bond	Sub-12
						1-2957	Sub-61	3，4-diClPh	SO2	Single bond	Sub-13
1-2958	Sub-61	3，4-diClPh	SO2	Single bond	Sub-14
						1-2959	Sub-61	3，4-diClPh	SO2	Single bond	Sub-15
1-2960	Sub-61	3，4-diClPh	SO2	Single bond	Sub-16
						1-2961	Sub-61	3，4-diClPh	SO2	Single bond	Sub-17
1-2962	Sub-61	3，4-diClPh	SO2	Single bond	Sub-18
						1-2963	Sub-61	3，4-diClPh	SO2	Single bond	Sub-19
1-2964	Sub-61	3，4-diClPh	SO2	Single bond	Sub-20

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2965	Sub-61	3，4-diClPh	SO2	Single bond	Sub-21
1-2966	Sub-61	3，4-diClPh	SO2	Single bond	Sub-22
						1-2967	Sub-61	3，4-diClPh	SO2	Single bond	Sub-23
1-2968	Sub-61	3，4-diClPh	SO2	Single bond	Sub-24
						1-2969	Sub-61	3，4-diClPh	SO2	Single bond	Sub-25
1-2970	Sub-61	3，4-diClPh	SO2	Single bond	Sub-26
						1-2971	Sub-61	3，4-diClPh	SO2	Single bond	Sub-27
1-2972	Sub-61	3，4-diClPh	SO2	Single bond	Sub-28
						1-2973	Sub-61	3，4-diClPh	SO2	Single bond	Sub-29
1-2974	Sub-61	3，4-diClPh	SO2	Single bond	Sub-30
						1-2975	Sub-61	3，4-diClPh	SO2	Single bond	Sub-31
1-2976	Sub-61	3，4-diClPh	SO2	Single bond	Sub-32
						1-2977	Sub-62	3，4-diClPh	SO2	Single bond	Sub-1
1-2978	Sub-62	3，4-diClPh	SO2	Single bond	Sub-2
						1-2979	Sub-62	3，4-diClPh	SO2	Single bond	Sub-3
1-2980	Sub-62	3，4-diClPh	SO2	Single bond	Sub-4
						1-2981	Sub-62	3，4-diClPh	SO2	Single bond	Sub-5
1-2982	Sub-62	3，4-diClPh	SO2	Single bond	Sub-6
						1-2983	Sub-62	3，4-diClPh	SO2	Single bond	Sub-7
1-2984	Sub-62	3，4-diClPh	SO2	Single bond	Sub-8
						1-2985	Sub-62	3，4-diClPh	SO2	Single bond	Sub-9
1-2986	Sub-62	3，4-diClPh	SO2	Single bond	Sub-10
						1-2987	Sub-62	3，4-diClPh	SO2	Single bond	Sub-11
1-2988	Sub-62	3，4-diClPh	SO2	Single bond	Sub-12
						1-2989	Sub-62	3，4-diClPh	SO2	Single bond	Sub-13
1-2990	Sub-62	3，4-diClPh	SO2	Single bond	Sub-14

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-2991	Sub-62	3，4-diClPh	SO2	Single bond	Sub-15
1-2992	Sub-62	3，4-diClPh	SO2	Single bond	Sub-16
						1-2993	Sub-62	3，4-diClPh	SO2	Single bond	Sub-17
1-2994	Sub-62	3，4-diClPh	SO2	Single bond	Sub-18
						1-2995	Sub-62	3，4-diClPh	SO2	Single bond	Sub-19
1-2996	Sub-62	3，4-diClPh	SO2	Single bond	Sub-20
						1-2997	Sub-62	3，4-diClPh	SO2	Single bond	Sub-21
1-2998	Sub-62	3，4-diClPh	SO2	Single bond	Sub-22
						1-2999	Sub-62	3，4-diClPh	SO2	Single bond	Sub-23
1-3000	Sub-62	3，4-diClPh	SO2	Single bond	Sub-24
						1-3001	Sub-62	3，4-diClPh	SO2	Single bond	Sub-25
1-3002	Sub-62	3，4-diClPh	SO2	Single bond	Sub-26
						1-3003	Sub-62	3，4-diClPh	SO2	Single bond	Sub-27
1-3004	Sub-62	3，4-diClPh	SO2	Single bond	Sub-28
						1-3005	Sub-62	3，4-diClPh	SO2	Single bond	Sub-29
1-3006	Sub-62	3，4-diClPh	SO2	Single bond	Sub-30
						1-3007	Sub-62	3，4-diClPh	SO2	Single bond	Sub-31
1-3008	Sub-62	3，4-diClPh	SO2	Single bond	Sub-32
						1-3009	Sub-63	3，4-diClPh	SO2	Single bond	Sub-1
1-3010	Sub-63	3，4-diClPh	SO2	Single bond	Sub-2
						1-3011	Sub-63	3，4-diClPh	SO2	Single bond	Sub-3
1-3012	Sub-63	3，4-diClPh	SO2	Single bond	Sub-4
						1-3013	Sub-63	3，4-diClPh	SO2	Single bond	Sub-5
1-3014	Sub-63	3，4-diClPh	SO2	Single bond	Sub-6
						1-3015	Sub-63	3，4-diClPh	SO2	Single bond	Sub-7
1-3016	Sub-63	3，4-diClPh	SO2	Single bond	Sub-8

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3017	Sub-63	3，4-diClPh	SO2	Single bond	Sub-9
1-3018	Sub-63	3，4-diClPh	SO2	Single bond	Sub-10
						1-3019	Sub-63	3，4-diClPh	SO2	Single bond	Sub-11
1-3020	Sub-63	3，4-diClPh	SO2	Single bond	Sub-12
						1-3021	Sub-63	3，4-diClPh	SO2	Single bond	Sub-13
1-3022	Sub-63	3，4-diClPh	SO2	Single bond	Sub-14
						1-3023	Sub-63	3，4-diClPh	SO2	Single bond	Sub-15
1-3024	Sub-63	3，4-diClPh	SO2	Single bond	Sub-16
						1-3025	Sub-63	3，4-diClPh	SO2	Single bond	Sub-17
1-3026	Sub-63	3，4-diClPh	SO2	Single bond	Sub-18
						1-3027	Sub-63	3，4-diClPh	SO2	Single bond	Sub-19
1-3028	Sub-63	3，4-diClPh	SO2	Single bond	Sub-20
						1-3029	Sub-63	3，4-diClPh	SO2	Single bond	Sub-21
1-3030	Sub-63	3，4-diClPh	SO2	Single bond	Sub-22
						1-3031	Sub-63	3，4-diClPh	SO2	Single bond	Sub-23
1-3032	Sub-63	3，4-diClPh	SO2	Single bond	Sub-24
						1-3033	Sub-63	3，4-diClPh	SO2	Single bond	Sub-25
1-3034	Sub-63	3，4-diClPh	SO2	Single bond	Sub-26
						1-3035	Sub-63	3，4-diClPh	SO2	Single bond	Sub-27
1-3036	Sub-63	3，4-diClPh	SO2	Single bond	Sub-28
						1-3037	Sub-63	3，4-diClPh	SO2	Single bond	Sub-29
1-3038	Sub-63	3，4-diClPh	SO2	Single bond	Sub-30
						1-3039	Sub-63	3，4-diClPh	SO2	Single bond	Sub-31
1-3040	Sub-63	3，4-diClPh	SO2	Single bond	Sub-32
						1-3041	Sub-64	3，4-diClPh	SO2	Single bond	Sub-1
1-3042	Sub-64	3，4-diClPh	SO2	Single bond	Sub-2

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3043	Sub-64	3，4-diClPh	SO2	Single bond	Sub-3
1-3044	Sub-64	3，4-diClPh	SO2	Single bond	Sub-4
						1-3045	Sub-64	3，4-diClPh	SO2	Single bond	Sub-5
1-3046	Sub-64	3，4-diClPh	SO2	Single bond	Sub-6
						1-3047	Sub-64	3，4-diClPh	SO2	Single bond	Sub-7
1-3048	Sub-64	3，4-diClPh	SO2	Single bond	Sub-8
						1-3049	Sub-64	3，4-diClPh	SO2	Single bond	Sub-9
1-3050	Sub-64	3，4-diClPh	SO2	Single bond	Sub-10
						1-3051	Sub-64	3，4-diClPh	SO2	Single bond	Sub-11
1-3052	Sub-64	3，4-diClPh	SO2	Single bond	Sub-12
						1-3053	Sub-64	3，4-diClPh	SO2	Single bond	Sub-13
1-3054	Sub-64	3，4-diClPh	SO2	Single bond	Sub-14
						1-3055	Sub-64	3，4-diClPh	SO2	Single bond	Sub-15
1-3056	Sub-64	3，4-diClPh	SO2	Single bond	Sub-16
						1-3057	Sub-64	3，4-diClPh	SO2	Single bond	Sub-17
1-3058	Sub-64	3，4-diClPh	SO2	Single bond	Sub-18
						1-3059	Sub-64	3，4-diClPh	SO2	Single bond	Sub-19
1-3060	Sub-64	3，4-diClPh	SO2	Single bond	Sub-20
						1-3061	Sub-64	3，4-diClPh	SO2	Single bond	Sub-21
1-3062	Sub-64	3，4-diClPh	SO2	Single bond	Sub-22
						1-3063	Sub-64	3，4-diClPh	SO2	Single bond	Sub-23
1-3064	Sub-64	3，4-diClPh	SO2	Single bond	Sub-24
						1-3065	Sub-64	3，4-diClPh	SO2	Single bond	Sub-25
1-3066	Sub-64	3，4-diClPh	SO2	Single bond	Sub-26
						1-3067	Sub-64	3，4-diClPh	SO2	Single bond	Sub-27
1-3068	Sub-64	3，4-diClPh	SO2	Single bond	Sub-28

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3069	Sub-64	3，4-diClPh	SO2	Single bond	Sub-29
1-3070	Sub-64	3，4-diClPh	SO2	Single bond	Sub-30
						1-3071	Sub-64	3，4-diClPh	SO2	Single bond	Sub-31
1-3072	Sub-64	3，4-diClPh	SO2	Single bond	Sub-32
						1-3073	Sub-33	3，4-diClPh	CO	CH2	Sub-1
1-3074	Sub-33	3，4-diClPh	CO	CH2	Sub-2
						1-3075	Sub-33	3，4-diClPh	CO	CH2	Sub-3
1-3076	Sub-33	3，4-diClPh	CO	CH2	Sub-4
						1-3077	Sub-33	3，4-diClPh	CO	CH2	Sub-5
1-3078	Sub-33	3，4-diClPh	CO	CH2	Sub-6
						1-3079	Sub-33	3，4-diClPh	CO	CH2	Sub-7
1-3080	Sub-33	3，4-diClPh	CO	CH2	Sub-8
						1-3081	Sub-33	3，4-diClPh	CO	CH2	Sub-9
1-3082	Sub-33	3，4-diClPh	CO	CH2	Sub-10
						1-3083	Sub-33	3，4-diClPh	CO	CH2	Sub-11
1-3084	Sub-33	3，4-diClPh	CO	CH2	Sub-12
						1-3085	Sub-33	3，4-diClPh	CO	CH2	Sub-13
1-3086	Sub-33	3，4-diClPh	CO	CH2	Sub-14
						1-3087	Sub-33	3，4-diClPh	CO	CH2	Sub-15
1-3088	Sub-33	3，4-diClPh	CO	CH2	Sub-16
						1-3089	Sub-33	3，4-diClPh	CO	CH2	Sub-17
1-3090	Sub-33	3，4-diClPh	CO	CH2	Sub-18
						1-3091	Sub-33	3，4-diClPh	CO	CH2	Sub-19
1-3092	Sub-33	3，4-diClPh	CO	CH2	Sub-20
						1-3093	Sub-33	3，4-diClPh	CO	CH2	Sub-21
1-3094	Sub-33	3，4-diClPh	CO	CH2	Sub-22

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3095	Sub-33	3，4-diClPh	CO	CH2	Sub-23
1-3096	Sub-33	3，4-diClPh	CO	CH2	Sub-24
						1-3097	Sub-33	3，4-diClPh	CO	CH2	Sub-25
1-3098	Sub-33	3，4-diClPh	CO	CH2	Sub-26
						1-3099	Sub-33	3，4-diClPh	CO	CH2	Sub-27
1-3100	Sub-33	3，4-diClPh	CO	CH2	Sub-28
						1-3101	Sub-33	3，4-diClPh	CO	CH2	Sub-29
1-3102	Sub-33	3，4-diClPh	CO	CH2	Sub-30
						1-3103	Sub-33	3，4-diClPh	CO	CH2	Sub-31
1-3104	Sub-33	3，4-diClPh	CO	CH2	Sub-32
						1-3105	Sub-34	3，4-diClPh	CO	CH2	Sub-1
1-3106	Sub-34	3，4-diClPh	CO	CH2	Sub-2
						1-3107	Sub-34	3，4-diClPh	CO	CH2	Sub-3
1-3108	Sub-34	3，4-diClPh	CO	CH2	Sub-4
						1-3109	Sub-34	3，4-diClPh	CO	CH2	Sub-5
1-3110	Sub-34	3，4-diClPh	CO	CH2	Sub-6
						1-3111	Sub-34	3，4-diClPh	CO	CH2	Sub-7
1-3112	Sub-34	3，4-diClPh	CO	CH2	Sub-8
						1-3113	Sub-34	3，4-diClPh	CO	CH2	Sub-9
1-3114	Sub-34	3，4-diClPh	CO	CH2	Sub-10
						1-3115	Sub-34	3，4-diClPh	CO	CH2	Sub-11
1-3116	Sub-34	3，4-diClPh	CO	CH2	Sub-12
						1-3117	Sub-34	3，4-diClPh	CO	CH2	Sub-13
1-3118	Sub-34	3，4-diClPh	CO	CH2	Sub-14
						1-3119	Sub-34	3，4-diClPh	CO	CH2	Sub-15
1-3120	Sub-34	3，4-diClPh	CO	CH2	Sub-16

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3121	Sub-34	3，4-diClPh	CO	CH2	Sub-17
1-3122	Sub-34	3，4-diClPh	CO	CH2	Sub-18
						1-3123	Sub-34	3，4-diClPh	CO	CH2	Sub-19
1-3124	Sub-34	3，4-diClPh	CO	CH2	Sub-20
						1-3125	Sub-34	3，4-diClPh	CO	CH2	Sub-21
1-3126	Sub-34	3，4-diClPh	CO	CH2	Sub-22
						1-3127	Sub-34	3，4-diClPh	CO	CH2	Sub-23
1-3128	Sub-34	3，4-diClPh	CO	CH2	Sub-24
						1-3129	Sub-34	3，4-diClPh	CO	CH2	Sub-25
1-3130	Sub-34	3，4-diClPh	CO	CH2	Sub-26
						1-3131	Sub-34	3，4-diClPh	CO	CH2	Sub-27
1-3132	Sub-34	3，4-diClPh	CO	CH2	Sub-28
						1-3133	Sub-34	3，4-diClPh	CO	CH2	Sub-29
1-3134	Sub-34	3，4-diClPh	CO	CH2	Sub-30
						1-3135	Sub-34	3，4-diClPh	CO	CH2	Sub-31
1-3136	Sub-34	3，4-diClPh	CO	CH2	Sub-32
						1-3137	Sub-35	3，4-diClPh	CO	CH2	Sub-1
1-3138	Sub-35	3，4-diClPh	CO	CH2	Sub-2
						1-3139	Sub-35	3，4-diClPh	CO	CH2	Sub-3
1-3140	Sub-35	3，4-diClPh	CO	CH2	Sub-4
						1-3141	Sub-35	3，4-diClPh	CO	CH2	Sub-5
1-3142	Sub-35	3，4-diClPh	CO	CH2	Sub-6
						1-3143	Sub-35	3，4-diClPh	CO	CH2	Sub-7
1-3144	Sub-35	3，4-diClPh	CO	CH2	Sub-8
						1-3145	Sub-35	3，4-diClPh	CO	CH2	Sub-9
1-3146	Sub-35	3，4-diClPh	CO	CH2	Sub-10

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3147	Sub-35	3，4-diClPh	CO	CH2	Sub-11
1-3148	Sub-35	3，4-diClPh	CO	CH2	Sub-12
						1-3149	Sub-35	3，4-diClPh	CO	CH2	Sub-13
1-3150	Sub-35	3，4-diClPh	CO	CH2	Sub-14
						1-3151	Sub-35	3，4-diClPh	CO	CH2	Sub-15
1-3152	Sub-35	3，4-diClPh	CO	CH2	Sub-16
						1-3153	Sub-35	3，4-diClPh	CO	CH2	Sub-17
1-3154	Sub-35	3，4-diClPh	CO	CH2	Sub-18
						1-3155	Sub-35	3，4-diClPh	CO	CH2	Sub-19
1-3156	Sub-35	3，4-diClPh	CO	CH2	Sub-20
						1-3157	Sub-35	3，4-diClPh	CO	CH2	Sub-21
1-3158	Sub-35	3，4-diClPh	CO	CH2	Sub-22
						1-3159	Sub-35	3，4-diClPh	CO	CH2	Sub-23
1-3160	Sub-35	3，4-diClPh	CO	CH2	Sub-24
						1-3161	Sub-35	3，4-diClPh	CO	CH2	Sub-25
1-3162	Sub-35	3，4-diClPh	CO	CH2	Sub-26
						1-3163	Sub-35	3，4-diClPh	CO	CH2	Sub-27
1-3164	Sub-35	3，4-diClPh	CO	CH2	Sub-28
						1-3165	Sub-35	3，4-diClPh	CO	CH2	Sub-29
1-3166	Sub-35	3，4-diClPh	CO	CH2	Sub-30
						1-3167	Sub-35	3，4-diClPh	CO	CH2	Sub-31
1-3168	Sub-35	3，4-diClPh	CO	CH2	Sub-32
						1-3169	Sub-36	3，4-diClPh	CO	CH2	Sub-1
1-3170	Sub-36	3，4-diClPh	CO	CH2	Sub-2
						1-3171	Sub-36	3，4-diClPh	CO	CH2	Sub-3
1-3172	Sub-36	3，4-diClPh	CO	CH2	Sub-4

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3173	Sub-36	3，4-diClPh	CO	CH2	Sub-5
1-3174	Sub-36	3，4-diClPh	CO	CH2	Sub-6
						1-3175	Sub-36	3，4-diClPh	CO	CH2	Sub-7
1-3176	Sub-36	3，4-diClPh	CO	CH2	Sub-8
						1-3177	Sub-36	3，4-diClPh	CO	CH2	Sub-9
1-3178	Sub-36	3，4-diClPh	CO	CH2	Sub-10
						1-3179	Sub-36	3，4-diClPh	CO	CH2	Sub-11
1-3180	Sub-36	3，4-diClPh	CO	CH2	Sub-12
						1-3181	Sub-36	3，4-diClPh	CO	CH2	Sub-13
1-3182	Sub-36	3，4-diClPh	CO	CH2	Sub-14
						1-3183	Sub-36	3，4-diClPh	CO	CH2	Sub-15
1-3184	Sub-36	3，4-diClPh	CO	CH2	Sub-16
						1-3185	Sub-36	3，4-diClPh	CO	CH2	Sub-17
1-3186	Sub-36	3，4-diClPh	CO	CH2	Sub-18
						1-3187	Sub-36	3，4-diClPh	CO	CH2	Sub-19
1-3188	Sub-36	3，4-diClPh	CO	CH2	Sub-20
						1-3189	Sub-36	3，4-diClPh	CO	CH2	Sub-21
1-3190	Sub-36	3，4-diClPh	CO	CH2	Sub-22
						1-3191	Sub-36	3，4-diClPh	CO	CH2	Sub-23
1-3192	Sub-36	3，4-diClPh	CO	CH2	Sub-24
						1-3193	Sub-36	3，4-diClPh	CO	CH2	Sub-25
1-3194	Sub-36	3，4-diClPh	CO	CH2	Sub-26
						1-3195	Sub-36	3，4-diClPh	CO	CH2	Sub-27
1-3196	Sub-36	3，4-diClPh	CO	CH2	Sub-28
						1-3197	Sub-36	3，4-diClPh	CO	CH2	Sub-29
1-3198	Sub-36	3，4-diClPh	CO	CH2	Sub-30

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3199	Sub-36	3，4-diClPh	CO	CH2	Sub-31
1-3200	Sub-36	3，4-diClPh	CO	CH2	Sub-32
						1-3201	Sub-37	3，4-diClPh	CO	CH2	Sub-1
1-3202	Sub-37	3，4-diClPh	CO	CH2	Sub-2
						1-3203	Sub-37	3，4-diClPh	CO	CH2	Sub-3
1-3204	Sub-37	3，4-diClPh	CO	CH2	Sub-4
						1-3205	Sub-37	3，4-diClPh	CO	CH2	Sub-5
1-3206	Sub-37	3，4-diClPh	CO	CH2	Sub-6
						1-3207	Sub-37	3，4-diClPh	CO	CH2	Sub-7
1-3208	Sub-37	3，4-diClPh	CO	CH2	Sub-8
						1-3209	Sub-37	3，4-diClPh	CO	CH2	Sub-9
1-3210	Sub-37	3，4-diClPh	CO	CH2	Sub-10
						1-3211	Sub-37	3，4-diClPh	CO	CH2	Sub-11
1-3212	Sub-37	3，4-diClPh	CO	CH2	Sub-12
						1-3213	Sub-37	3，4-diClPh	CO	CH2	Sub-13
1-3214	Sub-37	3，4-diClPh	CO	CH2	Sub-14
						1-3215	Sub-37	3，4-diClPh	CO	CH2	Sub-15
1-3216	Sub-37	3，4-diClPh	CO	CH2	Sub-16
						1-3217	Sub-37	3，4-diClPh	CO	CH2	Sub-17
1-3218	Sub-37	3，4-diClPh	CO	CH2	Sub-18
						1-3219	Sub-37	3，4-diClPh	CO	CH2	Sub-19
1-3220	Sub-37	3，4-diClPh	CO	CH2	Sub-20
						1-3221	Sub-37	3，4-diClPh	CO	CH2	Sub-21
1-3222	Sub-37	3，4-diClPh	CO	CH2	Sub-22
						1-3223	Sub-37	3，4-diClPh	CO	CH2	Sub-23
1-3224	Sub-37	3，4-diClPh	CO	CH2	Sub-24

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3225	Sub-37	3，4-diClPh	CO	CH2	Sub-25
1-3226	Sub-37	3，4-diClPh	CO	CH2	Sub-26
						1-3227	Sub-37	3，4-diClPh	CO	CH2	Sub-27
1-3228	Sub-37	3，4-diClPh	CO	CH2	Sub-28
						1-3229	Sub-37	3，4-diClPh	CO	CH2	Sub-29
1-3230	Sub-37	3，4-diClPh	CO	CH2	Sub-30
						1-3231	Sub-37	3，4-diClPh	CO	CH2	Sub-31
1-3232	Sub-37	3，4-diClPh	CO	CH2	Sub-32
						1-3233	Sub-38	3，4-diClPh	CO	CH2	Sub-1
1-3234	Sub-38	3，4-diClPh	CO	CH2	Sub-2
						1-3235	Sub-38	3，4-diClPh	CO	CH2	Sub-3
1-3236	Sub-38	3，4-diClPh	CO	CH2	Sub-4
						1-3237	Sub-38	3，4-diClPh	CO	CH2	Sub-5
1-3238	Sub-38	3，4-diClPh	CO	CH2	Sub-6
						1-3239	Sub-38	3，4-diClPh	CO	CH2	Sub-7
1-3240	Sub-38	3，4-diClPh	CO	CH2	Sub-8
						1-3241	Sub-38	3，4-diClPh	CO	CH2	Sub-9
1-3242	Sub-38	3，4-diClPh	CO	CH2	Sub-10
						1-3243	Sub-38	3，4-diClPh	CO	CH2	Sub-11
1-3244	Sub-38	3，4-diClPh	CO	CH2	Sub-12
						1-3245	Sub-38	3，4-diClPh	CO	CH2	Sub-13
1-3246	Sub-38	3，4-diClPh	CO	CH2	Sub-14
						1-3247	Sub-38	3，4-diClPh	CO	CH2	Sub-15
1-3248	Sub-38	3，4-diClPh	CO	CH2	Sub-16
						1-3249	Sub-38	3，4-diClPh	CO	CH2	Sub-17
1-3250	Sub-38	3，4-diClPh	CO	CH2	Sub-18

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3251	Sub-38	3，4-diClPh	CO	CH2	Sub-19
1-3252	Sub-38	3，4-diClPh	CO	CH2	Sub-20
						1-3253	Sub-38	3，4-diClPh	CO	CH2	Sub-21
1-3254	Sub-38	3，4-diClPh	CO	CH2	Sub-22
						1-3255	Sub-38	3，4-diClPh	CO	CH2	Sub-23
1-3256	Sub-38	3，4-diClPh	CO	CH2	Sub-24
						1-3257	Sub-38	3，4-diClPh	CO	CH2	Sub-25
1-3258	Sub-38	3，4-diClPh	CO	CH2	Sub-26
						1-3259	Sub-38	3，4-diClPh	CO	CH2	Sub-27
1-3260	Sub-38	3，4-diClPh	CO	CH2	Sub-28
						1-3261	Sub-38	3，4-diClPh	CO	CH2	Sub-29
1-3262	Sub-38	3，4-diClPh	CO	CH2	Sub-30
						1-3263	Sub-38	3，4-diClPh	CO	CH2	Sub-31
1-3264	Sub-38	3，4-diClPh	CO	CH2	Sub-32
						1-3265	Sub-39	3，4-diClPh	CO	CH2	Sub-1
1-3266	Sub-39	3，4-diClPh	CO	CH2	Sub-2
						1-3267	Sub-39	3，4-diClPh	CO	CH2	Sub-3
1-3268	Sub-39	3，4-diClPh	CO	CH2	Sub-4
						1-3269	Sub-39	3，4-diClPh	CO	CH2	Sub-5
1-3270	Sub-39	3，4-diClPh	CO	CH2	Sub-6
						1-3271	Sub-39	3，4-diClPh	CO	CH2	Sub-7
1-3272	Sub-39	3，4-diClPh	CO	CH2	Sub-8
						1-3273	Sub-39	3，4-diClPh	CO	CH2	Sub-9
1-3274	Sub-39	3，4-diClPh	CO	CH2	Sub-10
						1-3275	Sub-39	3，4-diClPh	CO	CH2	Sub-11
1-3276	Sub-39	3，4-diClPh	CO	CH2	Sub-12

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3277	Sub-39	3，4-diClPh	CO	CH2	Sub-13
1-3278	Sub-39	3，4-diClPh	CO	CH2	Sub-14
						1-3279	Sub-39	3，4-diClPh	CO	CH2	Sub-15
1-3280	Sub-39	3，4-diClPh	CO	CH2	Sub-16
						1-3281	Sub-39	3，4-diClPh	CO	CH2	Sub-17
1-3282	Sub-39	3，4-diClPh	CO	CH2	Sub-18
						1-3283	Sub-39	3，4-diClPh	CO	CH2	Sub-19
1-3284	Sub-39	3，4-diClPh	CO	CH2	Sub-20
						1-3285	Sub-39	3，4-diClPh	CO	CH2	Sub-21
1-3286	Sub-39	3，4-diClPh	CO	CH2	Sub-22
						1-3287	Sub-39	3，4-diClPh	CO	CH2	Sub-23
1-3288	Sub-39	3，4-diClPh	CO	CH2	Sub-24
						1-3289	Sub-39	3，4-diClPh	CO	CH2	Sub-25
1-3290	Sub-39	3，4-diClPh	CO	CH2	Sub-26
						1-3291	Sub-39	3，4-diClPh	CO	CH2	Sub-27
1-3292	Sub-39	3，4-diClPh	CO	CH2	Sub-28
						1-3293	Sub-39	3，4-diClPh	CO	CH2	Sub-29
1-3294	Sub-39	3，4-diClPh	CO	CH2	Sub-30
						1-3295	Sub-39	3，4-diClPh	CO	CH2	Sub-31
1-3296	Sub-39	3，4-diClPh	CO	CH2	Sub-32
						1-3297	Sub-40	3，4-diClPh	CO	CH2	Sub-1
1-3298	Sub-40	3，4-diClPh	CO	CH2	Sub-2
						1-3299	Sub-40	3，4-diClPh	CO	CH2	Sub-3
1-3300	Sub-40	3，4-diClPh	CO	CH2	Sub-4
						1-3301	Sub-40	3，4-diClPh	CO	CH2	Sub-5
1-3302	Sub-40	3，4-diClPh	CO	CH2	Sub-6

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3303	Sub-40	3，4-diClPh	CO	CH2	Sub-7
1-3304	Sub-40	3，4-diClPh	CO	CH2	Sub-8
						1-3305	Sub-40	3，4-diClPh	CO	CH2	Sub-9
1-3306	Sub-40	3，4-diClPh	CO	CH2	Sub-10
						1-3307	Sub-40	3，4-diClPh	CO	CH2	Sub-11
1-3308	Sub-40	3，4-diClPh	CO	CH2	Sub-12
						1-3309	Sub-40	3，4-diClPh	CO	CH2	Sub-13
1-3310	Sub-40	3，4-diClPh	CO	CH2	Sub-14
						1-3311	Sub-40	3，4-diClPh	CO	CH2	Sub-15
1-3312	Sub-40	3，4-diClPh	CO	CH2	Sub-16
						1-3313	Sub-40	3，4-diClPh	CO	CH2	Sub-17
1-3314	Sub-40	3，4-diClPh	CO	CH2	Sub-18
						1-3315	Sub-40	3，4-diClPh	CO	CH2	Sub-19
1-3316	Sub-40	3，4-diClPh	CO	CH2	Sub-20
						1-3317	Sub-40	3，4-diClPh	CO	CH2	Sub-21
1-3318	Sub-40	3，4-diClPh	CO	CH2	Sub-22
						1-3319	Sub-40	3，4-diClPh	CO	CH2	Sub-23
1-3320	Sub-40	3，4-diClPh	CO	CH2	Sub-24
						1-3321	Sub-40	3，4-diClPh	CO	CH2	Sub-25
l-3322	Sub-40	3，4-diClPh	CO	CH2	Sub-26
						1-3323	Sub-40	3，4-diClPh	CO	CH2	Sub-27
1-3324	Sub-40	3，4-diClPh	CO	CH2	Sub-28
						1-3325	Sub-40	3，4-diClPh	CO	CH2	Sub-29
1-3326	Sub-40	3，4-diClPh	CO	CH2	Sub-30
						1-3327	Sub-40	3，4-diClPh	CO	CH2	Sub-31
1-3328	Sub-40	3，4-diClPh	CO	CH2	Sub-32

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3329	Sub-41	3，4-diClPh	CO	CH2	Sub-1
1-3330	Sub-41	3，4-diClPh	CO	CH2	Sub-2
						1-3331	Sub-41	3，4-diClPh	CO	CH2	Sub-3
1-3332	Sub-41	3，4-diClPh	CO	CH2	Sub-4
						1-3333	Sub-41	3，4-diClPh	CO	CH2	Sub-5
1-3334	Sub-41	3，4-diClPh	CO	CH2	Sub-6
						1-3335	Sub-41	3，4-diClPh	CO	CH2	Sub-7
1-3336	Sub-41	3，4-diClPh	CO	CH2	Sub-8
						1-3337	Sub-41	3，4-diClPh	CO	CH2	Sub-9
1-3338	Sub-41	3，4-diClPh	CO	CH2	Sub-10
						1-3339	Sub-41	3，4-diClPh	CO	CH2	Sub-11
1-3340	Sub-41	3，4-diClPh	CO	CH2	Sub-12
						1-3341	Sub-41	3，4-diClPh	CO	CH2	Sub-13
1-3342	Sub-41	3，4-diClPh	CO	CH2	Sub-14
						1-3343	Sub-41	3，4-diClPh	CO	CH2	Sub-15
1-3344	Sub-41	3，4-diClPh	CO	CH2	Sub-16
						1-3345	Sub-41	3，4-diClPh	CO	CH2	Sub-17
1-3346	Sub-41	3，4-diClPh	CO	CH2	Sub-18
						1-3347	Sub-41	3，4-diClPh	CO	CH2	Sub-19
1-3348	Sub-41	3，4-diClPh	CO	CH2	Sub-20
						1-3349	Sub-41	3，4-diClPh	CO	CH2	Sub-21
1-3350	Sub-41	3，4-diClPh	CO	CH2	Sub-22
						1-3351	Sub-41	3，4-diClPh	CO	CH2	Sub-23
1-3352	Sub-41	3，4-diClPh	CO	CH2	Sub-24
						1-3353	Sub-41	3，4-diClPh	CO	CH2	Sub-25
1-3354	Sub-41	3，4-diClPh	CO	CH2	Sub-26

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3355	Sub-41	3，4-diClPh	CO	CH2	Sub-27
1-3356	Sub-41	3，4-diClPh	CO	CH2	Sub-28
						1-3357	Sub-41	3，4-diClPh	CO	CH2	Sub-29
1-3358	Sub-41	3，4-diClPh	CO	CH2	Sub-30
						1-3359	Sub-41	3，4-diClPh	CO	CH2	Sub-31
1-3360	Sub-41	3，4-diClPh	CO	CH2	Sub-32
						1-3361	Sub-42	3，4-diClPh	CO	CH2	Sub-1
1-3362	Sub-42	3，4-diClPh	CO	CH2	Sub-2
						1-3363	Sub-42	3，4-diClPh	CO	CH2	Sub-3
1-3364	Sub-42	3，4-diClPh	CO	CH2	Sub-4
						1-3365	Sub-42	3，4-diClPh	CO	CH2	Sub-5
1-3366	Sub-42	3，4-diClPh	CO	CH2	Sub-6
						1-3367	Sub-42	3，4-diClPh	CO	CH2	Sub-7
1-3368	Sub-42	3，4-diClPh	CO	CH2	Sub-8
						1-3369	Sub-42	3，4-diClPh	CO	CH2	Sub-9
1-3370	Sub-42	3，4-diClPh	CO	CH2	Sub-10
						1-3371	Sub-42	3，4-diClPh	CO	CH2	Sub-11
1-3372	Sub-42	3，4-diClPh	CO	CH2	Sub-12
						1-3373	Sub-42	3，4-diClPh	CO	CH2	Sub-13
1-3374	Sub-42	3，4-diClPh	CO	CH2	Sub-14
						1-3375	Sub-42	3，4-diClPh	CO	CH2	Sub-15
1-3376	Sub-42	3，4-diClPh	CO	CH2	Sub-16
						1-3377	Sub-42	3，4-diClPh	CO	CH2	Sub-17
1-3378	Sub-42	3，4-diClPh	CO	CH2	Sub-18
						1-3379	Sub-42	3，4-diClPh	CO	CH2	Sub-19
1-3380	Sub-42	3，4-diClPh	CO	CH2	Sub-20

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3381	Sub-42	3，4-diClPh	CO	CH2	Sub-21
1-3382	Sub-42	3，4-diClPh	CO	CH2	Sub-22
						1-3383	Sub-42	3，4-diClPh	CO	CH2	Sub-23
1-3384	Sub-42	3，4-diClPh	CO	CH2	Sub-24
						1-3385	Sub-42	3，4-diClPh	CO	CH2	Sub-25
1-3386	Sub-42	3，4-diClPh	CO	CH2	Sub-26
						1-3387	Sub-42	3，4-diClPh	CO	CH2	Sub-27
1-3388	Sub-42	3，4-diClPh	CO	CH2	Sub-28
						1-3389	Sub-42	3，4-diClPh	CO	CH2	Sub-29
1-3390	Sub-42	3，4-diClPh	CO	CH2	Sub-30
						1-3391	Sub-42	3，4-diClPh	CO	CH2	Sub-31
1-3392	Sub-42	3，4-diClPh	CO	CH2	Sub-32
						1-3393	Sub-43	3，4-diClPh	CO	CH2	Sub-1
1-3394	Sub-43	3，4-diClPh	CO	CH2	Sub-2
						1-3395	Sub-43	3，4-diClPh	CO	CH2	Sub-3
1-3396	Sub-43	3，4-diClPh	CO	CH2	Sub-4
						1-3397	Sub-43	3，4-diClPh	CO	CH2	Sub-5
1-3398	Sub-43	3，4-diClPh	CO	CH2	Sub-6
						1-3399	Sub-43	3，4-diClPh	CO	CH2	Sub-7
1-3400	Sub-43	3，4-diClPh	CO	CH2	Sub-8
						1-3401	Sub-43	3，4-diClPh	CO	CH2	Sub-9
1-3402	Sub-43	3，4-diClPh	CO	CH2	Sub-10
						1-3403	Sub-43	3，4-diClPh	CO	CH2	Sub-11
1-3404	Sub-43	3，4-diClPh	CO	CH2	Sub-12
						1-3405	Sub-43	3，4-diClPh	CO	CH2	Sub-13
1-3406	Sub-43	3，4-diClPh	CO	CH2	Sub-14

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3407	Sub-43	3，4-diClPh	CO	CH2	Sub-15
1-3408	Sub-43	3，4-diClPh	CO	CH2	Sub-16
						1-3409	Sub-43	3，4-diClPh	CO	CH2	Sub-17
1-3410	Sub-43	3，4-diClPh	CO	CH2	Sub-18
						1-3411	Sub-43	3，4-diClPh	CO	CH2	Sub-19
1-3412	Sub-43	3，4-diClPh	CO	CH2	Sub-20
						1-3413	Sub-43	3，4-diClPh	CO	CH2	Sub-21
1-3414	Sub-43	3，4-diClPh	CO	CH2	Sub-22
						1-3415	Sub-43	3，4-diClPh	CO	CH2	Sub-23
1-3416	Sub-43	3，4-diClPh	CO	CH2	Sub-24
						1-3417	Sub-43	3，4-diClPh	CO	CH2	Sub-25
1-3418	Sub-43	3，4-diClPh	CO	CH2	Sub-26
						1-3419	Sub-43	3，4-diClPh	CO	CH2	Sub-27
1-3420	Sub-43	3，4-diClPh	CO	CH2	Sub-28
						1-3421	Sub-43	3，4-diClPh	CO	CH2	Sub-29
1-3422	Sub-43	3，4-diClPh	CO	CH2	Sub-30
						1-3423	Sub-43	3，4-diClPh	CO	CH2	Sub-31
1-3424	Sub-43	3，4-diClPb	CO	CH2	Sub-32
						1-3425	Sub-44	3，4-diClPh	CO	CH2	Sub-1
1-3426	Sub-44	3，4-diClPh	CO	CH2	Sub-2
						1-3427	Sub-44	3，4-diClPh	CO	CH2	Sub-3
1-3428	Sub-44	3，4-diClPh	CO	CH2	Sub-4
						1-3429	Sub-44	3，4-diClPh	CO	CH2	Sub-5
1-3430	Sub-44	3，4-diClPh	CO	CH2	Sub-6
						1-3431	Sub-44	3，4-diClPh	CO	CH2	Sub-7
1-3432	Sub-44	3，4-diClPh	CO	CH2	Sub-8

Table1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3433	Sub-44	3，4-diClPh	CO	CH2	Sub-9
1-3434	Sub-44	3，4-diClPh	CO	CH2	Sub-10
						1-3435	Sub-44	3，4-diClPh	CO	CH2	Sub-11
1-3436	Sub-44	3，4-diClPh	CO	CH2	Sub-12
						1-3437	Sub-44	3，4-diClPh	CO	CH2	Sub-13
1-3438	Sub-44	3，4-diClPh	CO	CH2	Sub-14
						1-3439	Sub-44	3，4-diClPh	CO	CH2	Sub-15
1-3440	Sub-44	3，4-diClPh	CO	CH2	Sub-16
						1-3441	Sub-44	3，4-diClPh	CO	CH2	Sub-17
1-3442	Sub-44	3，4-diClPh	CO	CH2	Sub-18
						1-3443	Sub-44	3，4-diClPh	CO	CH2	Sub-19
1-3444	Sub-44	3，4-diC1Ph	CO	CH2	Sub-20
						1-3445	Sub-44	3，4-diClPh	CO	CH2	Sub-21
1-3446	Sub-44	3，4-diClPh	CO	CH2	Sub-22
						1-3447	Sub-44	3，4-diClPh	CO	CH2	Sub-23
1-3448	Sub-44	3，4-diClPh	CO	CH2	Sub-24
						1-3449	Sub-44	3，4-diClPh	CO	CH2	Sub-25
1-3450	Sub-44	3，4-diClPh	CO	CH2	Sub-26
						1-3451	Sub-44	3，4-diClPh	CO	CH2	Sub-27
1-3452	Sub-44	3，4-diClPh	CO	CH2	Sub-28
						1-3453	Sub-44	3，4-diClPh	CO	CH2	Sub-29
1-3454	Sub-44	3，4-diClPh	CO	CH2	Sub-30
						1-3455	Sub-44	3，4-diClPh	CO	CH2	Sub-31
1-3456	Sub-44	3，4-diClPh	CO	CH2	Sub-32
						1-3457	Sub-45	3，4-diClPh	CO	CH2	Sub-1
1-3458	Sub-45	3，4-diClPh	CO	CH2	Sub-2

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3459	Sub-45	3，4-diClPh	CO	CH2	Sub-3
1-3460	Sub-45	3，4-diClPh	CO	CH2	Sub-4
						1-3461	Sub-45	3，4-diClPh	CO	CH2	Sub-5
1-3462	Sub-45	3，4-diClPh	CO	CH2	Sub-6
						1-3463	Sub-45	3，4-diClPh	CO	CH2	Sub-7
1-3464	Sub-45	3，4-diClPh	CO	CH2	Sub-8
						1-3465	Sub-45	3，4-diClPh	CO	CH2	Sub-9
1-3466	Sub-45	3，4-diClPh	CO	CH2	Sub-10
						1-3467	Sub-45	3，4-diClPh	CO	CH2	Sub-11
1-3468	Sub-45	3，4-diClPh	CO	CH2	Sub-12
						1-3469	Sub-45	3，4-diClPh	CO	CH2	Sub-13
1-3470	Sub-45	3，4-diClPh	CO	CH2	Sub-14
						1-3471	Sub-45	3，4-diClPh	CO	CH2	Sub-15
1-3472	Sub-45	3，4-diClPh	CO	CH2	Sub-16
						1-3473	Sub-45	3，4-diClPh	CO	CH2	Sub-17
1-3474	Sub-45	3，4-diClPh	CO	CH2	Sub-18
						1-3475	Sub-45	3，4-diClPh	CO	CH2	Sub-19
1-3476	Sub-45	3，4-diClPh	CO	CH2	Sub-20
						1-3477	Sub-45	3，4-diClPh	CO	CH2	Sub-21
1-3478	Sub-45	3，4-diClPh	CO	CH2	Sub-22
						1-3479	Sub-45	3，4-diClPh	CO	CH2	Sub-23
1-3480	Sub-45	3，4-diClPh	CO	CH2	Sub-24
						1-3481	Sub-45	3，4-diClPh	CO	CH2	Sub-25
1-3482	Sub-45	3，4-diClPh	CO	CH2	Sub-26
						1-3483	Sub-45	3，4-diClPh	CO	CH2	Sub-27
1-3484	Sub-45	3，4-diClPh	CO	CH2	Sub-28

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3485	Sub-45	3，4-diClPh	CO	CH2	Sub-29
1-3486	Sub-45	3，4-diClPh	CO	CH2	Sub-30
						1-3487	Sub-45	3，4-diClPh	CO	CH2	Sub-31
1-3488	Sub-45	3，4-diClPh	CO	CH2	Sub-32
						1-3489	Sub-46	3，4-diClPh	CO	CH2	Sub-1
1-3490	Sub-46	3，4-diClPh	CO	CH2	Sub-2
						1-3491	Sub-46	3，4-diClPh	CO	CH2	Sub-3
1-3492	Sub-46	3，4-diClPh	CO	CH2	Sub-4
						1-3493	Sub-46	3，4-diClPh	CO	CH2	Sub-5
1-3494	Sub-46	3，4-diClPh	CO	CH2	Sub-6
						1-3495	Sub-46	3，4-diClPh	CO	CH2	Sub-7
1-3496	Sub-46	3，4-diClPh	CO	CH2	Sub-8
						1-3497	Sub-46	3，4-diClPh	CO	CH2	Sub-9
1-3498	Sub-46	3，4-diClPh	CO	CH2	Sub-10
						1-3499	Sub-46	3，4-diClPh	CO	CH2	Sub-11
1-3500	Sub-46	3，4-diClPh	CO	CH2	Sub-12
						1-3501	Sub-46	3，4-diClPh	CO	CH2	Sub-13
1-3502	Sub-46	3，4-diClPh	CO	CH2	Sub-14
						1-3503	Sub-46	3，4-diClPh	CO	CH2	Sub-15
1-3504	Sub-46	3，4-diClPh	CO	CH2	Sub-16
						1-3505	Sub-46	3，4-diClPh	CO	CH2	Sub-17
1-3506	Sub-46	3，4-diClPh	CO	CH2	Sub-18
						1-3507	Sub-46	3，4-diClPh	CO	CH2	Sub-19
1-3508	Sub-46	3，4-diClPh	CO	CH2	Sub-20
						1-3509	Sub-46	3，4-diClPh	CO	CH2	Sub-21
1-3510	Sub-46	3，4-diClPh	CO	CH2	Sub-22

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3511	Sub-46	3，4-diClPh	CO	CH2	Sub-23
1-3512	Sub-46	3，4-diClPh	CO	CH2	Sub-24
						1-3513	Sub-46	3，4-diClPh	CO	CH2	Sub-25
1-3514	Sub-46	3，4-diClPh	CO	CH2	Sub-26
						1-3515	Sub-46	3，4-diClPh	CO	CH2	Sub-27
1-3516	Sub-46	3，4-diClPh	CO	CH2	Sub-28
						1-3517	Sub-46	3，4-diClPh	CO	CH2	Sub-29
1-3518	Sub-46	3，4-diClPh	CO	CH2	Sub-30
						1-3519	Sub-46	3，4-diClPh	CO	CH2	Sub-31
1-3520	Sub-46	3，4-diClPh	CO	CH2	Sub-32
						1-352l	Sub-47	3，4-diClPh	CO	CH2	Sub-1
1-3522	Sub-47	3，4-diClPh	CO	CH2	Sub-2
						l-3523	Sub-47	3，4-diClPh	CO	CH2	Sub-3
1-3524	Sub-47	3，4-diClPh	CO	CH2	Sub-4
						1-3525	Sub-47	3，4-diClPh	CO	CH2	Sub-5
1-3526	Sub-47	3，4-diClPh	CO	CH2	Sub-6
						1-3527	Sub-47	3，4-diClPh	CO	CH2	Sub-7
1-3528	Sub-47	3，4-diClPh	CO	CH2	Sub-8
						1-3529	Sub-47	3，4-diClPh	CO	CH2	Sub-9
1-3530	Sub-47	3，4-diClPh	CO	CH2	Sub-10
						1-3531	Sub-47	3，4-diClPh	CO	CH2	Sub-11
1-3532	Sub-47	3，4-diClPh	CO	CH2	Sub-12
						1-3533	Sub-47	3，4-diClPh	CO	CH2	Sub-13
1-3534	Sub-47	3，4-diClPh	CO	CH2	Sub-14
						1-3535	Sub-47	3，4-diClPh	CO	CH2	Sub-15
1-3536	Sub-47	3，4-diClPh	CO	CH2	Sub-16

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3537	Sub-47	3，4-diClPh	CO	CH2	Sub-17
1-3538	Sub-47	3，4-diClPh	CO	CH2	Sub-18
						1-3539	Sub-47	3，4-diClPh	CO	CH2	Sub-19
1-3540	Sub-47	3，4-diClPh	CO	CH2	Sub-20
						1-3541	Sub-47	3，4-diClPh	CO	CH2	Sub-21
1-3542	Sub-47	3，4-diClPh	CO	CH2	Sub-22
						1-3543	Sub-47	3，4-diClPh	CO	CH2	Sub-23
1-3544	Sub-47	3，4-diClPh	CO	CH2	Sub-24
						1-3545	Sub-47	3，4-diClPh	CO	CH2	Sub-25
1-3546	Sub-47	3，4-diClPh	CO	CH2	Sub-26
						1-3547	Sub-47	3，4-diClPh	CO	CH2	Sub-27
1-3548	Sub-47	3，4-diClPh	CO	CH2	Sub-28
						1-3549	Sub-47	3，4-diClPh	CO	CH2	Sub-29
1-3550	Sub-47	3，4-diClPh	CO	CH2	Sub-30
						1-3551	Sub-47	3，4-diClPh	CO	CH2	Sub-31
1-3552	Sub-47	3，4-diClPh	CO	CH2	Sub-32
						1-3553	Sub-48	3，4-diClPh	CO	CH2	Sub-1
1-3554	Sub-48	3，4-diClPh	CO	CH2	Sub-2
						1-3555	Sub-48	3，4-diClPh	CO	CH2	Sub-3
1-3556	Sub-48	3，4-diClPh	CO	CH2	Sub-4
						1-3557	Sub-48	3，4-diClPh	CO	CH2	Sub-5
1-3558	Sub-48	3，4-diClPh	CO	CH2	Sub-6
						1-3559	Sub-48	3，4-diClPh	CO	CH2	Sub-7
1-3560	Sub-48	3，4-diClPh	CO	CH2	Sub-8
						1-3561	Sub-48	3，4-diClPh	CO	CH2	Sub-9
1-3562	Sub-48	3，4-diClPh	CO	CH2	Sub-10

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3563	Sub-48	3，4-diClPh	CO	CH2	Sub-11
1-3564	Sub-48	3，4-diClPh	CO	CH2	Sub-12
						1-3565	Sub-48	3，4-diClPh	CO	CH2	Sub-13
1-3566	Sub-48	3，4-diClPh	CO	CH2	Sub-14
						1-3567	Sub-48	3，4-diClPh	CO	CH2	Sub-15
1-3568	Sub-48	3，4-diClPh	CO	CH2	Sub-16
						1-3569	Sub-48	3，4-diClPh	CO	CH2	Sub-17
1-3570	Sub-48	3，4-diClPh	CO	CH2	Sub-18
						1-3571	Sub-48	3，4-diClPh	CO	CH2	Sub-19
1-3572	Sub-48	3，4-diClPh	CO	CH2	Sub-20
						1-3573	Sub-48	3，4-diClPh	CO	CH2	Sub-21
1-3574	Sub-48	3，4-diClPh	CO	CH2	Sub-22
						1-3575	Sub-48	3，4-diClPh	CO	CH2	Sub-23
1-3576	Sub-48	3，4-diClPh	CO	CH2	Sub-24
						1-3577	Sub-48	3，4-diClPh	CO	CH2	Sub-25
1-3578	Sub-48	3，4-diClPh	CO	CH2	Sub-26
						1-3579	Sub-48	3，4-diClPh	CO	CH2	Sub-27
1-3580	Sub-48	3，4-diClPh	CO	CH2	Sub-28
						1-3581	Sub-48	3，4-diClPh	CO	CH2	Sub-29
1-3582	Sub-48	3，4-diClPh	CO	CH2	Sub-30
						1-3583	Sub-48	3，4-diClPh	CO	CH2	Sub-31
1-3584	Sub-48	3，4-diClPh	CO	CH2	Sub-32
						1-3585	Sub-49	3，4-diClPh	CO	CH2	Sub-1
1-3586	Sub-49	3，4-diClPh	CO	CH2	Sub-2
						1-3587	Sub-49	3，4-diClPh	CO	CH2	Sub-3
1-3588	Sub-49	3，4-diClPh	CO	CH2	Sub-4

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3589	Sub-49	3，4-diClPh	CO	CH2	Sub-5
1-3590	Sub-49	3，4-diClPh	CO	CH2	Sub-6
						1-3591	Sub-49	3，4-diClPh	CO	CH2	Sub-7
1-3592	Sub-49	3，4-diClPh	CO	CH2	Sub-8
						1-3593	Sub-49	3，4-diClPh	CO	CH2	Sub-9
1-3594	Sub-49	3，4-diClPh	CO	CH2	Sub-10
						1-3595	Sub-49	3，4-diClPh	CO	CH2	Sub-11
1-3596	Sub-49	3，4-diClPh	CO	CH2	Sub-12
						1-3597	Sub-49	3，4-diClPh	CO	CH2	Sub-13
1-3598	Sub-49	3，4-diClPh	CO	CH2	Sub-14
						1-3599	Sub-49	3，4-diClPh	CO	CH2	Sub-15
1-3600	Sub-49	3，4-diClPh	CO	CH2	Sub-16
						1-3601	Sub-49	3，4-diClPh	CO	CH2	Sub-17
1-3602	Sub-49	3，4-diClPh	CO	CH2	Sub-18
						1-3603	Sub-49	3，4-diClPh	CO	CH2	Sub-19
1-3604	Sub-49	3，4-diClPh	CO	CH2	Sub-20
						1-3605	Sub-49	3，4-diClPh	CO	CH2	Sub-21
1-3606	Sub-49	3，4-diClPh	CO	CH2	Sub-22
						1-3607	Sub-49	3，4-diClPh	CO	CH2	Sub-23
1-3608	Sub-49	3，4-diClPh	CO	CH2	Sub-24
						1-3609	Sub-49	3，4-diClPh	CO	CH2	Sub-25
1-3610	Sub-49	3，4-diClPh	CO	CH2	Sub-26
						1-3611	Sub-49	3，4-diC1Ph	CO	CH2	Sub-27
1-3612	Sub-49	3，4-diClPh	CO	CH2	Sub-28
						1-3613	Sub-49	3，4-diClPh	CO	CH2	Sub-29
1-3614	Sub-49	3，4-diClPh	CO	CH2	Sub-30

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3615	Sub-49	3，4-diClPh	CO	CH2	Sub-31
1-3616	Sub-49	3，4-diClPh	CO	CH2	Sub-32
						1-3617	Sub-50	3，4-diClPh	CO	CH2	Sub-1
1-3618	Sub-50	3，4-diClPh	CO	CH2	Sub-2
						1-3619	Sub-50	3，4-diClPh	CO	CH2	Sub-3
1-3620	Sub-50	3，4-diClPh	CO	CH2	Sub-4
						1-3621	Sub-50	3，4-diClPh	CO	CH2	Sub-5
1-3622	Sub-50	3，4-diClPh	CO	CH2	Sub-6
						1-3623	Sub-50	3，4-diClPh	CO	CH2	Sub-7
1-3624	Sub-50	3，4-diClPh	CO	CH2	Sub-8
						1-3625	Sub-50	3，4-diClPh	CO	CH2	Sub-9
1-3626	Sub-50	3，4-diClPh	CO	CH2	Sub-10
						1-3627	Sub-50	3，4-diClPh	CO	CH2	Sub-11
1-3628	Sub-50	3，4-diClPh	CO	CH2	Sub-12
						1-3629	Sub-50	3，4-diClPh	CO	CH2	Sub-13
1-3630	Sub-50	3，4-diClPh	CO	CH2	Sub-14
						1-3631	Sub-50	3，4-diClPh	CO	CH2	Sub-15
1-3632	Sub-50	3，4-diClPh	CO	CH2	Sub-16
						1-3633	Sub-50	3，4-diClPh	CO	CH2	Sub-17
1-3634	Sub-50	3，4-diClPh	CO	CH2	Sub-18
						1-3635	Sub-50	3，4-diClPh	CO	CH2	Sub-19
1-3636	Sub-50	3，4-diClPh	CO	CH2	Sub-20
						1-3637	Sub-50	3，4-diClPh	CO	CH2	Sub-21
1-3638	Sub-50	3，4-diClPh	CO	CH2	Sub-22
						1-3639	Sub-50	3，4-diClPh	CO	CH2	Sub-23
1-3640	Sub-50	3，4-diClPh	CO	CH2	Sub-24

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3641	Sub-50	3，4-diClPh	CO	CH2	Sub-25
1-3642	Sub-50	3，4-diClPh	CO	CH2	Sub-26
						1-3643	Sub-50	3，4-diClPh	CO	CH2	Sub-27
1-3644	Sub-50	3，4-diClPh	CO	CH2	Sub-28
						1-3645	Sub-50	3，4-diClPh	CO	CH2	Sub-29
1-3646	Sub-50	3，4-diClPh	CO	CH2	Sub-30
						1-3647	Sub-50	3，4-diClPh	CO	CH2	Sub-31
1-3648	Sub-50	3，4-diClPh	CO	CH2	Sub-32
						1-3649	Sub-51	3，4-diClPh	CO	CH2	Sub-1
1-3650	Sub-51	3，4-diClPh	CO	CH2	Sub-2
						1-3651	Sub-51	3，4-diClPh	CO	CH2	Sub-3
1-3652	Sub-51	3，4-diClPh	CO	CH2	Sub-4
						1-3653	Sub-51	3，4-diClPh	CO	CH2	Sub-5
1-3654	Sub-51	3，4-diClPh	CO	CH2	Sub-6
						1-3655	Sub-51	3，4-diClPh	CO	CH2	Sub-7
1-3656	Sub-51	3，4-diClPh	CO	CH2	Sub-8
						1-3657	Sub-51	3，4-diClPh	CO	CH2	Sub-9
1-3658	Sub-51	3，4-diClPh	CO	CH2	Sub-10
						1-3659	Sub-51	3，4-diClPh	CO	CH2	Sub-11
1-3660	Sub-51	3，4-diClPh	CO	CH2	Sub-12
						1-3661	Sub-51	3，4-diClPh	CO	CH2	Sub-13
1-3662	Sub-51	3，4-diClPh	CO	CH2	Sub-14
						1-3663	Sub-51	3，4-diClPh	CO	CH2	Sub-15
1-3664	Sub-51	3，4-diClPh	CO	CH2	Sub-16
						1-3665	Sub-51	3，4-diClPh	CO	CH2	Sub-17
1-3666	Sub-51	3，4-diClPh	CO	CH2	Sub-18

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3667	Sub-51	3，4-diClPh	CO	CH2	Sub-19
1-3668	Sub-51	3，4-diClPh	CO	CH2	Sub-20
						1-3669	Sub-51	3，4-diClPh	CO	CH2	Sub-21
1-3670	Sub-51	3，4-diClPh	CO	CH2	Sub-22
						1-3671	Sub-51	3，4-diClPh	CO	CH2	Sub-23
1-3672	Sub-51	3，4-diClPh	CO	CH2	Sub-24
						1-3673	Sub-51	3，4-diClPh	CO	CH2	Sub-25
1-3674	Sub-51	3，4-diClPh	CO	CH2	Sub-26
						1-3675	Sub-51	3，4-diClPh	CO	CH2	Sub-27
1-3676	Sub-51	3，4-diClPh	CO	CH2	Sub-28
						1-3677	Sub-51	3，4-diClPh	CO	CH2	Sub-29
1-3678	Sub-51	3，4-diClPh	CO	CH2	Sub-30
						1-3679	Sub-51	3，4-diClPh	CO	CH2	Sub-31
1-3680	Sub-51	3，4-diClPh	CO	CH2	Sub-32
						1-3681	Sub-52	3，4-diClPh	CO	CH2	Sub-1
1-3682	Sub-52	3，4-diClPh	CO	CH2	Sub-2
						1-3683	Sub-52	3，4-diClPh	CO	CH2	Sub-3
1-3684	Sub-52	3，4-diClPh	CO	CH2	Sub-4
						1-3685	Sub-52	3，4-diClPh	CO	CH2	Sub-5
1-3686	Sub-52	3，4-diClPh	CO	CH2	Sub-6
						1-3687	Sub-52	3，4-diClPh	CO	CH2	Sub-7
1-3688	Sub-52	3，4-diClPh	CO	CH2	Sub-8
						1-3689	Sub-52	3，4-diClPh	CO	CH2	Sub-9
1-3690	Sub-52	3，4-diC1Ph	CO	CH2	Sub-10
						1-3691	Sub-52	3，4-diClPh	CO	CH2	Sub-11
1-3692	Sub-52	3，4-diClPh	CO	CH2	Sub-12

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3693	Sub-52	3，4-diClPh	CO	CH2	Sub-13
1-3694	Sub-52	3，4-diClPh	CO	CH2	Sub-14
						1-3695	Sub-52	3，4-diClPh	CO	CH2	Sub-15
1-3696	Sub-52	3，4-diClPh	CO	CH2	Sub-16
						1-3697	Sub-52	3，4-diClPh	CO	CH2	Sub-17
1-3698	Sub-52	3，4-diClPh	CO	CH2	Sub-18
						1-3699	Sub-52	3，4-diClPh	CO	CH2	Sub-19
1-3700	Sub-52	3，4-diClPh	CO	CH2	Sub-20
						1-3701	Sub-52	3，4-diClPh	CO	CH2	Sub-21
1-3702	Sub-52	3，4-diClPh	CO	CH2	Sub-22
						1-3703	Sub-52	3，4-diClPh	CO	CH2	Sub-23
1-3704	Sub-52	3，4-diClPh	CO	CH2	Sub-24
						1-3705	Sub-52	3，4-diClPh	CO	CH2	Sub-25
1-3706	Sub-52	3，4-diClPh	CO	CH2	Sub-26
						1-3707	Sub-52	3，4-diClPh	CO	CH2	Sub-27
1-3708	Sub-52	3，4-diClPh	CO	CH2	Sub-28
						1-3709	Sub-52	3，4-diClPh	CO	CH2	Sub-29
1-3710	Sub-52	3，4-diClPh	CO	CH2	Sub-30
						1-3711	Sub-52	3，4-diClPh	CO	CH2	Sub-31
1-3712	Sub-52	3，4-diClPh	CO	CH2	Sub-32
						1-3713	Sub-53	3，4-diClPh	CO	CH2	Sub-1
1-3714	Sub-53	3，4-diClPh	CO	CH2	Sub-2
						1-3715	Sub-53	3，4-diClPh	CO	CH2	Sub-3
1-3716	Sub-53	3，4-diClPh	CO	CH2	Sub-4
						1-3717	Sub-53	3，4-diClPh	CO	CH2	Sub-5
1-3718	Sub-53	3，4-diClPh	CO	CH2	Sub-6

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3719	Sub-53	3，4-diClPh	CO	CH2	Sub-7
1-3720	Sub-53	3，4-diClPh	CO	CH2	Sub-8
						1-3721	Sub-53	3，4-diClPh	CO	CH2	Sub-9
1-3722	Sub-53	3，4-diClPh	CO	CH2	Sub-10
						1-3723	Sub-53	3，4-diClPh	CO	CH2	Sub-11
1-3724	Sub-53	3，4-diClPh	CO	CH2	Sub-12
						1-3725	Sub-53	3，4-diClPh	CO	CH2	Sub-13
1-3726	Sub-53	3，4-diClPh	CO	CH2	Sub-14
						1-3727	Sub-53	3，4-diClPh	CO	CH2	Sub-15
1-3728	Sub-53	3，4-diClPh	CO	CH2	Sub-16
						1-3729	Sub-53	3，4-diClPh	CO	CH2	Sub-17
1-3730	Sub-53	3，4-diClPh	CO	CH2	Sub-18
						1-3731	Sub-53	3，4-diClPh	CO	CH2	Sub-19
1-3732	Sub-53	3，4-diClPh	CO	CH2	Sub-20
						1-3733	Sub-53	3，4-diClPh	CO	CH2	Sub-21
1-3734	Sub-53	3，4-diClPh	CO	CH2	Sub-22
						1-3735	Sub-53	3，4-diClPh	CO	CH2	Sub-23
1-3736	Sub-53	3，4-diClPh	CO	CH2	Sub-24
						1-3737	Sub-53	3，4-diClPh	CO	CH2	Sub-25
1-3738	Sub-53	3，4-diClPh	CO	CH2	Sub-26
						1-3739	Sub-53	3，4-diClPh	CO	CH2	Sub-27
1-3740	Sub-53	3，4-diClPh	CO	CH2	Sub-28
						1-3741	Sub-53	3，4-diClPh	CO	CH2	Sub-29
1-3742	Sub-53	3，4-diClPh	CO	CH2	Sub-30
						1-3743	Sub-53	3，4-diClPh	CO	CH2	Sub-31
1-3744	Sub-53	3，4-diClPh	CO	CH2	Sub-32

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3745	Sub-54	3，4-diClPh	CO	CH2	Sub-1
1-3746	Sub-54	3，4-diClPh	CO	CH2	Sub-2
						1-3747	Sub-54	3，4-diClPh	CO	CH2	Sub-3
1-3748	Sub-54	3，4-diClPh	CO	CH2	Sub-4
						1-3749	Sub-54	3，4-diClPh	CO	CH2	Sub-5
1-3750	Sub-54	3，4-diClPh	CO	CH2	Sub-6
						1-3751	Sub-54	3，4-diClPh	CO	CH2	Sub-7
1-3752	Sub-54	3，4-diClPh	CO	CH2	Sub-8
						1-3753	Sub-54	3，4-diClPh	CO	CH2	Sub-9
1-3754	Sub-54	3，4-diClPh	CO	CH2	Sub-10
						1-3755	Sub-54	3，4-diClPh	CO	CH2	Sub-11
1-3756	Sub-54	3，4-diClPh	CO	CH2	Sub-12
						1-3757	Sub-54	3，4-diClPh	CO	CH2	Sub-13
1-3758	Sub-54	3，4-diClPh	CO	CH2	Sub-14
						1-3759	Sub-54	3，4-diClPh	CO	CH2	Sub-15
1-3760	Sub-54	3，4-diClPh	CO	CH2	Sub-16
						1-3761	Sub-54	3，4-diClPh	CO	CH2	Sub-17
1-3762	Sub-54	3，4-diClPh	CO	CH2	Sub-18
						1-3763	Sub-54	3，4-diClPh	CO	CH2	Sub-19
1-3764	Sub-54	3，4-diClPh	CO	CH2	Sub-20
						1-3765	Sub-54	3，4-diClPh	CO	CH2	Sub-21
1-3766	Sub-54	3，4-diClPh	CO	CH2	Sub-22
						1-3767	Sub-54	3，4-diClPh	CO	CH2	Sub-23
1-3768	Sub-54	3，4-diClPh	CO	CH2	Sub-24
						1-3769	Sub-54	3，4-diClPh	CO	CH2	Sub-25
1-3770	Sub-54	3，4-diClPh	CO	CH2	Sub-26

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3771	Sub-54	3，4-diClPh	CO	CH2	Sub-27
1-3772	Sub-54	3，4-diClPh	CO	CH2	Sub-28
						1-3773	Sub-54	3，4-diClPh	CO	CH2	Sub-29
1-3774	Sub-54	3，4-diClPh	CO	CH2	Sub-30
						1-3775	Sub-54	3，4-diClPh	CO	CH2	Sub-31
1-3776	Sub-54	3，4-diClPh	CO	CH2	Sub-32
						1-3777	Sub-55	3，4-diClPh	CO	CH2	Sub-1
1-3778	Sub-55	3，4-diClPh	CO	CH2	Sub-2
						1-3779	Sub-55	3，4-diClPh	CO	CH2	Sub-3
1-3780	Sub-55	3，4-diClPh	CO	CH2	Sub-4
						1-3781	Sub-55	3，4-diClPh	CO	CH2	Sub-5
1-3782	Sub-55	3，4-diClPh	CO	CH2	Sub-6
						1-3783	Sub-55	3，4-diClPh	CO	CH2	Sub-7
1-3784	Sub-55	3，4-diClPh	CO	CH2	Sub-8
						1-3785	Sub-55	3，4-diClPh	CO	CH2	Sub-9
1-3786	Sub-55	3，4-diClPh	CO	CH2	Sub-10
						1-3787	Sub-55	3，4-diClPh	CO	CH2	Sub-11
1-3788	Sub-55	3，4-diClPh	CO	CH2	Sub-12
						1-3789	Sub-55	3，4-diClPh	CO	CH2	Sub-13
1-3790	Sub-55	3，4-diClPh	CO	CH2	Sub-14
						1-3791	Sub-55	3，4-diClPh	CO	CH2	Sub-15
1-3792	Sub-55	3，4-diClPh	CO	CH2	Sub-16
						1-3793	Sub-55	3，4-diClPh	CO	CH2	Sub-17
1-3794	Sub-55	3，4-diClPh	CO	CH2	Sub-18
						1-3795	Sub-55	3，4-diClPh	CO	CH2	Sub-19
1-3796	Sub-55	3，4-diClPh	CO	CH2	Sub-20

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3797	Sub-55	3，4-diClPh	CO	CH2	Sub-21
1-3798	Sub-55	3，4-diClPh	CO	CH2	Sub-22
						1-3799	Sub-55	3，4-diClPh	CO	CH2	Sub-23
1-3800	Sub-55	3，4-diClPh	CO	CH2	Sub-24
						1-3801	Sub-55	3，4-diClPh	CO	CH2	Sub-25
1-3802	Sub-55	3，4-diClPh	CO	CH2	Sub-26
						1-3803	Sub-55	3，4-diClPh	CO	CH2	Sub-27
1-3804	Sub-55	3，4-diClPh	CO	CH2	Sub-28
						1-3805	Sub-55	3，4-diClPh	CO	CH2	Sub-29
1-3806	Sub-55	3，4-diClPh	CO	CH2	Sub-30
						1-3807	Sub-55	3，4-diClPh	CO	CH2	Sub-31
1-3808	Sub-55	3，4-diClPh	CO	CH2	Sub-32
						1-3809	Sub-56	3，4-diClPh	CO	CH2	Sub-1
1-3810	Sub-56	3，4-diClPh	CO	CH2	Sub-2
						1-3811	Sub-56	3，4-diClPh	CO	CH2	Sub-3
1-3812	Sub-56	3，4-diClPh	CO	CH2	Sub-4
						1-3813	Sub-56	3，4-diClPh	CO	CH2	Sub-5
1-3814	Sub-56	3，4-diClPh	CO	CH2	Sub-6
						1-3815	Sub-56	3，4-diClPh	CO	CH2	Sub-7
1-3816	Sub-56	3，4-diClPh	CO	CH2	Sub-8
						1-3817	Sub-56	3，4-diClPh	CO	CH2	Sub-9
1-3818	Sub-56	3，4-diClPh	CO	CH2	Sub-10
						1-3819	Sub-56	3，4-diClPh	CO	CH2	Sub-11
1-3820	Sub-56	3，4-diClPh	CO	CH2	Sub-12
						1-3821	Sub-56	3，4-diClPh	CO	CH2	Sub-13
1-3822	Sub-56	3，4-diClPh	CO	CH2	Sub-14

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3823	Sub-56	3，4-diClPh	CO	CH2	Sub-15
1-3824	Sub-56	3，4-diClPh	CO	CH2	Sub-16
						1-3825	Sub-56	3，4-diClPh	CO	CH2	Sub-17
1-3826	Sub-56	3，4-diClPh	CO	CH2	Sub-18
						1-3827	Sub-56	3，4-diClPh	CO	CH2	Sub-19
1-3828	Sub-56	3，4-diClPh	CO	CH2	Sub-20
						1-3829	Sub-56	3，4-diClPh	CO	CH2	Sub-21
1-3830	Sub-56	3，4-diClPh	CO	CH2	Sub-22
						1-3831	Sub-56	3，4-diClPh	CO	CH2	Sub-23
1-3832	Sub-56	3，4-diClPh	CO	CH2	Sub-24
						1-3833	Sub-56	3，4-diClPh	CO	CH2	Sub-25
1-3834	Sub-56	3，4-diClPh	CO	CH2	Sub-26
						1-3835	Sub-56	3，4-diClPh	CO	CH2	Sub-27
1-3836	Sub-56	3，4-diClPh	CO	CH2	Sub-28
						1-3837	Sub-56	3，4-diClPh	CO	CH2	Sub-29
1-3838	Sub-56	3，4-diClPh	CO	CH2	Sub-30
						1-3839	Sub-56	3，4-diClPh	CO	CH2	Sub-31
1-3840	Sub-56	3，4-diClPh	CO	CH2	Sub-32
						1-3841	Sub-57	3，4-diClPh	CO	CH2	Sub-1
1-3842	Sub-57	3，4-diCldh	CO	CH2	Sub-2
						1-3843	Sub-57	3，4-diClPh	CO	CH2	Sub-3
1-3844	Sub-57	3，4-diClPh	CO	CH2	Sub-4
						1-3845	Sub-57	3，4-diClPh	CO	CH2	Sub-5
1-3846	Sub-57	3，4-diClPh	CO	CH2	Sub-6
						1-3847	Sub-57	3，4-diClPh	CO	CH2	Sub-7
1-3848	Sub-57	3，4-diClPh	CO	CH2	Sub-8

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3849	Sub-57	3，4-diClPh	CO	CH2	Sub-9
1-3850	Sub-57	3，4-diClPh	CO	CH2	Sub-10
						1-3851	Sub-57	3，4-diClPh	CO	CH2	Sub-11
1-3852	Sub-57	3，4-diClPh	CO	CH2	Sub-12
						1-3853	Sub-57	3，4-diClPh	CO	CH2	Sub-13
1-3854	Sub-57	3，4-diClPh	CO	CH2	Sub-14
						1-3855	Sub-57	3，4-diClPh	CO	CH2	Sub-15
1-3856	Sub-57	3，4-diClPh	CO	CH2	Sub-16
						1-3857	Sub-57	3，4-diClPh	CO	CH2	Sub-17
1-3858	Sub-57	3，4-diClPh	CO	CH2	Sub-18
						1-3859	Sub-57	3，4-diClPh	CO	CH2	Sub-19
1-3860	Sub-57	3，4-diClPh	CO	CH2	Sub-20
						1-3861	Sub-57	3，4-diClPh	CO	CH2	Sub-21
1-3862	Sub-57	3，4-diClPh	CO	CH2	Sub-22
						1-3863	Sub-57	3，4-diClPh	CO	CH2	Sub-23
1-3864	Sub-57	3，4-diClPh	CO	CH2	Sub-24
						1-3865	Sub-57	3，4-diClPh	CO	CH2	Sub-25
1-3866	Sub-57	3，4-diClPh	CO	CH2	Sub-26
						1-3867	Sub-57	3，4-diClPh	CO	CH2	Sub-27
1-3868	Sub-57	3，4-diClPh	CO	CH2	Sub-28
						1-3869	Sub-57	3，4-diClPh	CO	CH2	Sub-29
1-3870	Sub-57	3，4-diClPh	CO	CH2	Sub-30
						1-3871	Sub-57	3，4-diClPh	CO	CH2	Sub-31
1-3872	Sub-57	3，4-diClPh	CO	CH2	Sub-32
						1-3873	Sub-58	3，4-diClPh	CO	CH2	Sub-1
1-3874	Sub-58	3，4-diClPh	CO	CH2	Sub-2

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3875	Sub-58	3，4-diClPh	CO	CH2	Sub-3
1-3876	Sub-58	3，4-diClPh	CO	CH2	Sub-4
						1-3877	Sub-58	3，4-diClPh	CO	CH2	Sub-5
1-3878	Sub-58	3，4-diClPh	CO	CH2	Sub-6
						1-3879	Sub-58	3，4-diClPh	CO	CH2	Sub-7
1-3880	Sub-58	3，4-diClPh	CO	CH2	Sub-8
						1-3881	Sub-58	3，4-diClPh	CO	CH2	Sub-9
1-3882	Sub-58	3，4-diClPh	CO	CH2	Sub-10
						1-3883	Sub-58	3，4-diClPh	CO	CH2	Sub-11
1-3884	Sub-58	3，4-diClPh	CO	CH2	Sub-12
						1-3885	Sub-58	3，4-diClPh	CO	CH2	Sub-13
1-3886	Sub-58	3，4-diClPh	CO	CH2	Sub-14
						1-3887	Sub-58	3，4-diClPh	CO	CH2	Sub-15
1-3888	Sub-58	3，4-diClPh	CO	CH2	Sub-16
						1-3889	Sub-58	3，4-diClPh	CO	CH2	Sub-17
1-3890	Sub-58	3，4-diClPh	CO	CH2	Sub-18
						1-3891	Sub-58	3，4-diClPh	CO	CH2	Sub-19
1-3892	Sub-58	3，4-diClPh	CO	CH2	Sub-20
						1-3893	Sub-58	3，4-diClPh	CO	CH2	Sub-21
1-3894	Sub-58	3，4-diClPh	CO	CH2	Sub-22
						1-3895	Sub-58	3，4-diClPh	CO	CH2	Sub-23
1-3896	Sub-58	3，4-diClPh	CO	CH2	Sub-24
						1-3897	Sub-58	3，4-diClPh	CO	CH2	Sub-25
1-3898	Sub-58	3，4-diClPh	CO	CH2	Sub-26
						1-3899	Sub-58	3，4-diClPh	CO	CH2	Sub-27
1-3900	Sub-58	3，4-diClPh	CO	CH2	Sub-28

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3901	Sub-58	3，4-diClPh	CO	CH2	Sub-29
1-3902	Sub-58	3，4-diClPh	CO	CH2	Sub-30
						1-3903	Sub-58	3，4-diClPh	CO	CH2	Sub-31
1-3904	Sub-58	3，4-diClPh	CO	CH2	Sub-32
						1-3905	Sub-59	3，4-diClPh	CO	CH2	Sub-1
1-3906	Sub-59	3，4-diClPh	CO	CH2	Sub-2
						1-3907	Sub-59	3，4-diClPh	CO	CH2	Sub-3
1-3908	Sub-59	3，4-diClPh	CO	CH2	Sub-4
						1-3909	Sub-59	3，4-diClPh	CO	CH2	Sub-5
1-3910	Sub-59	3，4-diClPh	CO	CH2	Sub-6
						1-3911	Sub-59	3，4-diClPh	CO	CH2	Sub-7
1-3912	Sub-59	3，4-diClPh	CO	CH2	Sub-8
						1-3913	Sub-59	3，4-diClPh	CO	CH2	Sub-9
1-3914	Sub-59	3，4-diClPh	CO	CH2	Sub-10
						1-3915	Sub-59	3，4-diClPh	CO	CH2	Sub-11
1-3916	Sub-59	3，4-diClPh	CO	CH2	Sub-12
						1-3917	Sub-59	3，4-diClPh	CO	CH2	Sub-13
1-3918	Sub-59	3，4-diClPh	CO	CH2	Sub-14
						1-3919	Sub-59	3，4-diClPh	CO	CH2	Sub-15
1-3920	Sub-59	3，4-diClPh	CO	CH2	Sub-16
						1-3921	Sub-59	3，4-diClPh	CO	CH2	Sub-17
1-3922	Sub-59	3，4-diClPh	CO	CH2	Sub-18
						1-3923	Sub-59	3，4-diClPh	CO	CH2	Sub-19
1-3924	Sub-59	3，4-diClPh	CO	CH2	Sub-20
						1-3925	Sub-59	3，4-diClPh	CO	CH2	Sub-21
1-3926	Sub-59	3，4-diClPh	CO	CH2	Sub-22

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3927	Sub-59	3，4-diClPh	CO	CH2	Sub-23
1-3928	Sub-59	3，4-diClPh	CO	CH2	Sub-24
						1-3929	Sub-59	3，4-diClPh	CO	CH2	Sub-25
1-3930	Sub-59	3，4-diClPh	CO	CH2	Sub-26
						1-3931	Sub-59	3，4-diClPh	CO	CH2	Sub-27
1-3932	Sub-59	3，4-diClPh	CO	CH2	Sub-28
						1-3933	Sub-59	3，4-diClPh	CO	CH2	Sub-29
1-3934	Sub-59	3，4-diClPh	CO	CH2	Sub-30
						1-3935	Sub-59	3，4-diClPh	CO	CH2	Sub-31
1-3936	Sub-59	3，4-diClPh	CO	CH2	Sub-32
						1-3937	Sub-60	3，4-diClPh	CO	CH2	Sub-1
1-3938	Sub-60	3，4-diClPh	CO	CH2	Sub-2
						1-3939	Sub-60	3，4-diClPh	CO	CH2	Sub-3
1-3940	Sub-60	3，4-diClPh	CO	CH2	Sub-4
						1-3941	Sub-60	3，4-diClPh	CO	CH2	Sub-5
1-3942	Sub-60	3，4-diClPh	CO	CH2	Sub-6
						1-3943	Sub-60	3，4-diClPh	CO	CH2	Sub-7
1-3944	Sub-60	3，4-diClPh	CO	CH2	Sub-8
						1-3945	Sub-60	3，4-diClPh	CO	CH2	Sub-9
1-3946	Sub-60	3，4-diClPh	CO	CH2	Sub-10
						1-3947	Sub-60	3，4-diClPh	CO	CH2	Sub-11
1-3948	Sub-60	3，4-diClPh	CO	CH2	Sub-12
						1-3949	Sub-60	3，4-diClPh	CO	CH2	Sub-13
1-3950	Sub-60	3，4-diClPh	CO	CH2	Sub-14
						1-3951	Sub-60	3，4-diClPh	CO	CH2	Sub-15
1-3952	Sub-60	3，4-diClPh	CO	CH2	Sub-16

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3953	Sub-59	3，4-diClPh	CO	CH2	Sub-17
1-3954	Sub-59	3，4-diClPh	CO	CH2	Sub-18
						1-3955	Sub-59	3，4-diClPh	CO	CH2	Sub-19
1-3956	Sub-59	3，4-diClPh	CO	CH2	Sub-20
						1-3957	Sub-59	3，4-diClPh	CO	CH2	Sub-21
1-3958	Sub-59	3，4-diClPh	CO	CH2	Sub-22
						1-3959	Sub-59	3，4-diClPh	CO	CH2	Sub-23
1-3960	Sub-59	3，4-diClPh	CO	CH2	Sub-24
						1-3961	Sub-59	3，4-diClPh	CO	CH2	Sub-25
1-3962	Sub-59	3，4-diClPh	CO	CH2	Sub-26
						1-3963	Sub-60	3，4-diClPh	CO	CH2	Sub-27
1-3964	Sub-60	3，4-diClPh	CO	CH2	Sub-28
						1-3965	Sub-60	3，4-diClPh	CO	CH2	Sub-29
1-3966	Sub-60	3，4-diClPh	CO	CH2	Sub-30
						1-3967	Sub-60	3，4-diClPh	CO	CH2	Sub-31
1-3968	Sub-60	3，4-diClPh	CO	CH2	Sub-32
						1-3969	Sub-61	3，4-diClPh	CO	CH2	Sub-1
1-3970	Sub-61	3，4-diClPh	CO	CH2	Sub-2
						1-3971	Sub-61	3，4-diClPh	CO	CH2	Sub-3
1-3972	Sub-61	3，4-diClPh	CO	CH2	Sub-4
						1-3973	Sub-61	3，4-diClPh	CO	CH2	Sub-5
1-3974	Sub-61	3，4-diClPh	CO	CH2	Sub-6
						1-3975	Sub-61	3，4-diClPh	CO	CH2	Sub-7
1-3976	Sub-61	3，4-diClPh	CO	CH2	Sub-8
						1-3977	Sub-61	3，4-diClPh	CO	CH2	Sub-9
1-3978	Sub-61	3，4-diClPh	CO	CH2	Sub-10

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-3979	Sub-61	3，4-diClPh	CO	CH2	Sub-11
1-3980	Sub-61	3，4-diClPh	CO	CH2	Sub-12
						1-3981	Sub-61	3，4-diClPh	CO	CH2	Sub-13
1-3982	Sub-61	3，4-diClPh	CO	CH2	Sub-14
						1-3983	Sub-61	3，4-diClPh	CO	CH2	Sub-15
1-3984	Sub-61	3，4-diClPh	CO	CH2	Sub-16
						1-3985	Sub-61	3，4-diClPh	CO	CH2	Sub-17
1-3986	Sub-61	3，4-diClPh	CO	CH2	Sub-18
						1-3987	Sub-61	3，4-diClPh	CO	CH2	Sub-19
1-3988	Sub-61	3，4-diClPh	CO	CH2	Sub-20
						1-3989	Sub-61	3，4-diClPh	CO	CH2	Sub-21
1-3990	Sub-61	3，4-diClPh	CO	CH2	Sub-22
						1-3991	Sub-61	3，4-diClPh	CO	CH2	Sub-23
1-3992	Sub-61	3，4-diClPh	CO	CH2	Sub-24
						1-3993	Sub-61	3，4-diClPh	CO	CH2	Sub-25
1-3994	Sub-61	3，4-diClPh	CO	CH2	Sub-26
						1-3995	Sub-61	3，4-diClPh	CO	CH2	Sub-27
1-3996	Sub-61	3，4-diClPh	CO	CH2	Sub-28
						1-3997	Sub-61	3，4-diClPh	CO	CH2	Sub-29
1-3998	Sub-61	3，4-diClPh	CO	CH2	Sub-30
						1-3999	Sub-61	3，4-diClPh	CO	CH2	Sub-31
1-4000	Sub-61	3，4-diClPh	CO	CH2	Sub-32
						1-4001	Sub-62	3，4-diClPh	CO	CH2	Sub-1
1-4002	Sub-62	3，4-diClPh	CO	CH2	Sub-2
						1-4003	Sub-62	3，4-diClPh	CO	CH2	Sub-3
1-4004	Sub-62	3，4-diClPh	CO	CH2	Sub-4

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-4005	Sub-62	3，4-diClPh	CO	CH2	Sub-5
1-4006	Sub-62	3，4-diClPh	CO	CH2	Sub-6
						1-4007	Sub-62	3，4-diClPh	CO	CH2	Sub-7
1-4008	Sub-62	3，4-diClPh	CO	CH2	Sub-8
						1-4009	Sub-62	3，4-diClPh	CO	CH2	Sub-9
1-4010	Sub-62	3，4-diClPh	CO	CH2	Sub-10
						1-4011	Sub-62	3，4-diClPh	CO	CH2	Sub-11
1-4012	Sub-62	3，4-diClPh	CO	CH2	Sub-12
						1-4013	Sub-62	3，4-diClPh	CO	CH2	Sub-13
1-4014	Sub-62	3，4-diClPh	CO	CH2	Sub-14
						1-4015	Sub-62	3，4-diClPh	CO	CH2	Sub-15
1-4016	Sub-62	3，4-diClPh	CO	CH2	Sub-16
						1-4017	Sub-62	3，4-diClPh	CO	CH2	Sub-17
1-4018	Sub-62	3，4-diClPh	CO	CH2	Sub-18
						1-4019	Sub-62	3，4-diClPh	CO	CH2	Sub-19
1-4020	Sub-62	3，4-diClPh	CO	CH2	Sub-20
						1-4021	Sub-62	3，4-diClPh	CO	CH2	Sub-21
1-4022	Sub-62	3，4-diClPh	CO	CH2	Sub-22
						1-4023	Sub-62	3，4-diClPh	CO	CH2	Sub-23
1-4024	Sub-62	3，4-diClPh	CO	CH2	Sub-24
						1-4025	Sub-62	3，4-diClPh	CO	CH2	Sub-25
1-4026	Sub-62	3，4-diClPh	CO	CH2	Sub-26
						1-4027	Sub-62	3，4-diClPh	CO	CH2	SHb-27
1-4028	Sub-62	3，4-diClPh	CO	CH2	Sub-28
						1-4029	Sub-62	3，4-diClPh	CO	CH2	Sub-29
1-4030	Sub-62	3，4-diClPh	CO	CH2	Sub-30

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-4031	Sub-62	3，4-diClPh	CO	CH2	Sub-31
1-4032	Sub-62	3，4-diClPh	CO	CH2	Sub-32
						1-4033	Sub-63	3，4-diClPh	CO	CH2	Sub-1
1-4034	Sub-63	3，4-diClPh	CO	CH2	Sub-2
						1-4035	Sub-63	3，4-diClPh	CO	CH2	Sub-3
1-4036	Sub-63	3，4-diClPh	CO	CH2	Sub-4
						1-4037	Sub-63	3，4-diClPh	CO	CH2	Sub-5
1-4038	Sub-63	3，4-diClPh	CO	CH2	Sub-6
						1-4039	Sub-63	3，4-diCiPh	CO	CH2	Sub-7
1-4040	Sub-63	3，4-diClPh	CO	CH2	Sub-8
						1-4041	Sub-63	3，4-diClPh	CO	CH2	Sub-9
1-4042	Sub-63	3，4-diClPh	CO	CH2	Sub-10
						1-4043	Sub-63	3，4-diClPh	CO	CH2	Sub-11
1-4044	Sub-63	3，4-diClPh	CO	CH2	Sub-12
						1-4045	Sub-63	3，4-diClPh	CO	CH2	Sub-13
1-4046	Sub-63	3，4-diClPh	CO	CH2	Sub-14
						1-4047	Sub-63	3，4-diClPh	CO	CH2	Sub-15
1-4048	Sub-63	3，4-diClPh	CO	CH2	Sub-16
						1-4049	Sub-63	3，4-diClPh	CO	CH2	Sub-17
1-4050	Sub-63	3，4-diClPh	CO	CH2	Sub-18
						1-4051	Sub-63	3，4-diClPh	CO	CH2	Sub-19
1-4052	Sub-63	3，4-diClPh	CO	CH2	Sub-20
						1-4053	Sub-63	3，4-diClPh	CO	CH2	Sub-21
1-4054	Sub-63	3，4-diClPh	CO	CH2	Sub-22
						1-4055	Sub-63	3，4-diClPh	CO	CH2	Sub-23
1-4056	Sub-63	3，4-diClPh	CO	CH2	Sub-24

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-4057	Sub-63	3，4-diClPh	CO	CH2	Sub-25
1-4058	Sub-63	3，4-diClPh	CO	CH2	Sub-26
						1-4059	Sub-63	3，4-diClPh	CO	CH2	Sub-27
1-4060	Sub-63	3，4-diClPh	CO	CH2	Sub-28
						1-4061	Sub-63	3，4-diClPh	CO	CH2	Sub-29
1-4062	Sub-63	3，4-diClPh	CO	CH2	Sub-30
						1-4063	Sub-63	3，4-diClPh	CO	CH2	Sub-31
1-4064	Sub-63	3，4-diClPh	CO	CH2	Sub-32
						1-4065	Sub-64	3，4-diClPh	CO	CH2	Sub-1
1-4066	Sub-64	3，4-diClPh	CO	CH2	Sub-2
						1-4067	Sub-64	3，4-diClPh	CO	CH2	Sub-3
1-4068	Sub-64	3，4-diClPh	CO	CH2	Sub-4
						1-4069	Sub-64	3，4-diClPh	CO	CH2	Sub-5
1-4070	Sub-64	3，4-diClPh	CO	CH2	Sub-6
						1-4071	Sub-64	3，4-diClPh	CO	CH2	Sub-7
1-4072	Sub-64	3，4-diClPh	CO	CH2	Sub-8
						1-4073	Sub-64	3，4-diClPh	CO	CH2	Sub-9
1-4074	Sub-64	3，4-diClPh	CO	CH2	Sub-10
						1-4075	Sub-64	3，4-diClPh	CO	CH2	Sub-11
1-4076	Sub-64	3，4-diClPh	CO	CH2	Sub-12
						1-4077	0ub-64	3，4-diClPh	CO	CH2	Sub-13
1-4078	Sub-64	3，4-diClPh	CO	CH2	Sub-14
						1-4079	Sub-64	3，4-diClPh	CO	CH2	Sub-15
1-4080	Sub-64	3，4-diClPh	CO	CH2	Sub-16
						1-4081	Sub-64	3，4-diClPh	CO	CH2	Sub-17
1-4082	Sub-64	3，4-diClPh	CO	CH2	Sub-18

Table 1(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						1-4083	Sub-64	3，4-diClPh	CO	CH2	Sub-19
1-4084	Sub-64	3，4-diClPh	CO	CH2	Sub-20
						1-4085	Sub-64	3，4-diClPh	CO	CH2	Sub-21
1-4086	Sub-64	3，4-diClPh	CO	CH2	Sub-22
						1-4087	Sub-64	3，4-diClPh	CO	CH2	Sub-23
1-4088	Sub-64	3，4-diClPh	CO	CH2	Sub-24
						1-4089	Sub-64	3，4-diClPh	CO	CH2	Sub-25
1-4090	Sub-64	3，4-diClPh	CO	CH2	Sub-26
						1-4091	Sub-64	3，4-diClPh	CO	CH2	Sub-27
1-4092	Sub-64	3，4-diClPh	CO	CH2	Sub-28
						1-4093	Sub-64	3，4-diClPh	CO	CH2	Sub-29
1-4094	Sub-64	3，4-diClPh	CO	CH2	Sub-30
						1-4095	Sub-64	3，4-diClPh	CO	CH2	Sub-31
1-4096	Sub-64	3，4-diClPh	CO	CH2	Sub-32

TABLE 2

Compound (I) Serial number	R1	R2	A	B	Z
						2-1	Sub-33	3，4-diClPh	CH2	Single bond	Sub-1
2-2	Sub-33	3，4-diClPh	CH2	Single bond	Sub-2
						2-3	Sub-33	3，4-diClPh	CH2	Single bond	Sub-3
2-4	Sub-33	3，4-diClPh	CH2	Single bond	Sub-4
						2-5	Sub-33	3，4-diClPh	CH2	Single bond	Sub-5
2-6	Sub-33	3，4-diClPh	CH2	Single bond	Sub-6
						2-7	Sub-33	3，4-diClPh	CH2	Single bond	Sub-7
2-8	Sub-33	3，4-diClPh	CH2	Single bond	Sub-8
						2-9	Sub-33	3，4-diClPh	CH2	Single bond	Sub-9
2-10	Sub-33	3，4-diClPh	CH2	Single bond	Sub-10
						2-11	Sub-33	3，4-diClPh	CH2	Single bond	Sub-11
2-12	Sub-33	3，4-diClPh	CH2	Single bond	Sub-12
						2-13	Sub-33	3，4-diClPh	CH2	Single bond	Sub-13
2-14	Sub-33	3，4-diClPh	CH2	Single bond	Sub-14
						2-15	Sub-33	3，4-diClPh	CH2	Single bond	Sub-15
2-16	Sub-33	3，4-diClPh	CH2	Single bond	Sub-16
						2-17	Sub-33	3，4-diClPh	CH2	Single bond	Sub-17
2-18	Sub-33	3，4-diClPh	CH2	Single bond	Sub-18
						2-19	Sub-33	3，4-diClPh	CH2	Single bond	Sub-19
2-20	Sub-33	3，4-diClPh	CH2	Single bond	Sub-20
						2-21	Sub-33	3，4-diClPh	CH2	Single bond	Sub-21
2-22	Sub-33	3，4-diClPh	CH2	Single bond	Sub-22
						2-23	Sub-33	3，4-diClPh	CH2	Single bond	Sub-23
2-24	Sub-33	3，4-diClPh	CH2	Single bond	Sub-24
						2-25	Sub-33	3，4-diClPh	CH2	Single bond	Sub-25
2-26	Sub-33	3，4-diClPh	CH2	Single bond	Sub-26

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-27	Sub-33	3，4-diClPh	CH2	Single bond	Sub-27
2-28	Sub-33	3，4-diClPh	CH2	Single bond	Sub-28
						2-29	Sub-33	3，4-diClPh	CH2	Single bond	Sub-29
2-30	Sub-33	3，4-diClPh	CH2	Single bond	Sub-30
						2-31	Sub-33	3，4-diClPh	CH2	Single bond	Sub-31
2-32	Sub-33	3，4-diClPh	CH2	Single bond	Sub-32
						2-33	Sub-33	3，4-diClPh	CH2	Single bond	Sub-65
2-34	Sub-33	3，4-diClPh	CH2	Single bond	Sub-66
						2-35	Sub-33	3，4-diClPh	CH2	Single bond	Sub-67
2-36	Sub-33	3，4-diClPh	CH2	Single bond	Sub-68
						2-37	Sub-33	3，4-diClPh	CH2	Single bond	Sub-69
2-38	Sub-33	3，4-diClPh	CH2	Single bond	Sub-70
						2-39	Sub-33	3，4-diClPh	CH2	Single bond	Sub-71
2-40	Sub-33	3，4-diClPh	CH2	Single bond	Sub-72
						2-41	Sub-33	3，4-diClPh	CH2	Single bond	Sub-73
2-42	Sub-33	3，4-diClPh	CH2	Single bond	Sub-74
						2-43	Sub-33	3，4-diClPh	CH2	Single bond	Sub-75
2-44	Sub-33	3，4-diClPh	CH2	Single bond	Sub-76
						2-45	Sub-33	3，4-diClPh	CH2	Single bond	Sub-77
2-46	Sub-33	3，4-diClPh	CH2	Single bond	Sub-78
						2-47	Sub-33	3，4-diClPh	CH2	Single bond	Sub-79
2-48	Sub-33	3，4-diClPh	CH2	Single bond	Sub-80
						2-49	Sub-34	3，4-diClPh	CH2	Single bond	Sub-1
2-50	Sub-34	3，4-diClPh	CH2	Single bond	Sub-2
						2-51	Sub-34	3，4-diClPh	CH2	Single bond	Sub-3
2-52	Sub-34	3，4-diClPh	CH2	Single bond	Sub-4

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-53	Sub-34	3，4-diClPh	CH2	Single bond	Sub-5
2-54	Sub-34	3，4-diClPh	CH2	Single bond	Sub-6
						2-55	Sub-34	3，4-diClPh	CH2	Single bond	Sub-7
2-56	Sub-34	3，4-diClPh	CH2	Single bond	Sub-8
						2-57	Sub-34	3，4-diClPh	CH2	Single bond	Sub-9
2-58	Sub-34	3，4-diClPh	CH2	Single bond	Sub-10
						2-59	Sub-34	3，4-diClPh	CH2	Single bond	Sub-11
2-60	Sub-34	3，4-diClPh	CH2	Single bond	Sub-12
						2-61	Sub-34	3，4-diClPh	CH2	Single bond	Sub-13
2-62	Sub-34	3，4-diClPh	CH2	Single bond	Sub-14
						2-63	Sub-34	3，4-diClPh	CH2	Single bond	Sub-15
2-64	Sub-34	3，4-diClPh	CH2	Single bond	Sub-16
						2-65	Sub-34	3，4-diClPh	CH2	Single bond	Sub-17
2-66	Sub-34	3，4-diClPh	CH2	Single bond	Sub-18
						2-67	Sub-34	3，4-diClPh	CH2	Single bond	Sub-19
2-68	Sub-34	3，4-diClPh	CH2	Single bond	Sub-20
						2-69	Sub-34	3，4-diClPh	CH2	Single bond	Sub-21
2-70	Sub-34	3，4-diClPh	CH2	Single bond	Sub-22
						2-71	Sub-34	3，4-diClPh	CH2	Single bond	Sub-23
2-72	Sub-34	3，4-diClPh	CH2	Single bond	Sub-24
						2-73	Sub-34	3，4-diClPh	CH2	Single bond	Sub-25
2-74	Sub-34	3，4-diClPh	CH2	Single bond	Sub-26
						2-75	Sub-34	3，4-diClPh	CH2	Single bond	Sub-27
2-76	Sub-34	3，4-diClPh	CH2	Single bond	Sub-28
						2-77	Sub-34	3，4-diClPh	CH2	Single bond	Sub-29
2-78	Sub-34	3，4-diClPh	CH2	Single bond	Sub-30

Table 2(cont.)

The compound sequence Number (C)	R1	R2	A	B	Z
						2-79	Sub-34	3，4-diClPh	CH2	Single bond	Sub-31
2-80	Sub-34	3，4-diClPh	CH2	Single bond	Sub-32
						2-81	Sub-34	3，4-diClPh	CH2	Single bond	Sub-65
2-82	Sub-34	3，4-diClPh	CH2	Single bond	Sub-66
						2-83	Sub-34	3，4-diClPh	CH2	Single bond	Sub-67
2-84	Sub-34	3，4-diClPh	CH2	Single bond	Sub-68
						2-85	Sub-34	3，4-diClPh	CH2	Single bond	Sub-69
2-86	Sub-34	3，4-diClPh	CH2	Single bond	Sub-70
						2-87	Sub-34	3，4-diClPh	CH2	Single bond	Sub-71
2-88	Sub-34	3，4-diClPh	CH2	Single bond	Sub-72
						2-89	Sub-34	3，4-diClPh	CH2	Single bond	Sub-73
2-90	Sub-34	3，4-diClPh	CH2	Single bond	Sub-74
						2-91	Sub-34	3，4-diClPh	CH2	Single bond	Sub-75
2-92	Sub-34	3，4-diClPh	CH2	Single bond	Sub-76
						2-93	Sub-34	3，4-diClPh	CH2	Single bond	Sub-77
2-94	Sub-34	3，4-diClPh	CH2	Single bond	Sub-78
						2-95	Sub-34	3，4-diClPh	CH2	Single bond	Sub-79
2-96	Sub-34	3，4-diClPh	CH2	Single bond	Sub-80
						2-97	Sub-35	3，4-diClPh	CH2	Single bond	Sub-1
2-98	Sub-35	3，4-diClPh	CH2	Single bond	Sub-2
						2-99	Sub-35	3，4-diClPh	CH2	Single bond	Sub-3
2-100	Sub-35	3，4-diClPh	CH2	Single bond	Sub-4
						2-101	Sub-35	3，4-diClPh	CH2	Single bond	Sub-5
2-102	Sub-35	3，4-diClPh	CH2	Single bond	Sub-6
						2-103	Sub-35	3，4-diClPh	CH2	Single bond	Sub-7
2-104	Sub-35	3，4-diClPh	CH2	Single bond	Sub-8

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-105	Sub-35	3，4-diClPh	CH2	Single bond	Sub-9
2-106	Sub-35	3，4-diClPh	CH2	Single bond	Sub-10
						2-107	Sub-35	3，4-diClPh	CH2	Single bond	Sub-11
2-108	Sub-35	3，4-diClPh	CH2	Single bond	Sub-12
						2-109	Sub-35	3，4-diClPh	CH2	Single bond	Sub-13
2-110	Sub-35	3，4-diClPh	CH2	Single bond	Sub-14
						2-111	Sub-35	3，4-diClPh	CH2	Single bond	Sub-15
2-112	Sub-35	3，4-diClPh	CH2	Single bond	Sub-16
						2-113	Sub-35	3，4-diClPh	CH2	Single bond	Sub-17
2-114	Sub-35	3，4-diClPh	CH2	Single bond	Sub-18
						2-115	Sub-35	3，4-diClPh	CH2	Single bond	Sub-19
2-116	Sub-35	3，4-diClPH	CH2	Single bond	Sub-20
						2-117	Sub-35	3，4-diClPh	CH2	Single bond	Sub-21
2-118	Sub-35	3，4-diClPh	CH2	Single bond	Sub-22
						2-119	Sub-35	3，4-diClPh	CH2	Single bond	Sub-23
2-120	Sub-35	3，4-diClPh	CH2	Single bond	Sub-24
						2-121	Sub-35	3，4-diClPh	CH2	Single bond	Sub-25
2-122	Sub-35	3，4-diClPh	CH2	Single bond	Sub-26
						2-123	Sub-35	3，4-diClPh	CH2	Single bond	Sub-27
2-124	Sub-35	3，4-diClPh	CH2	Single bond	Sub-28
						2-125	Sub-35	3，4-diClPh	CH2	Single bond	Sub-29
2-126	Sub-35	3，4-diClPh	CH2	Single bond	Sub-30
						2-127	Sub-35	3，4-diClPh	CH2	Single bond	Sub-31
2-128	Sub-35	3，4-diClPh	CH2	Single bond	Sub-32
						2-129	Sub-35	3，4-diClPh	CH2	Single bond	Sub-65
2-130	Sub-35	3，4-diClPh	CH2	Single bond	Sub-66

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-131	Sub-35	3，4-diClPh	CH2	Single bond	Sub-67
2-132	Sub-35	3，4-diClPh	CH2	Single bond	Sub-68
						2-133	Sub-35	3，4-diClPh	CH2	Single bond	Sub-69
2-134	Sub-35	3，4-diClPh	CH2	Single bond	Sub-70
						2-135	Sub-35	3，4-diClPh	CH2	Single bond	Sub-71
2-136	Sub-35	3，4-diClPh	CH2	Single bond	Sub-72
						2-137	Sub-35	3，4-diClPh	CH2	Single bond	Sub-73
2-138	Sub-35	3，4-diClPh	CH2	Single bond	Sub-74
						2-139	Sub-35	3，4-diClPh	CH2	Single bond	Sub-75
2-140	Sub-35	3，4-diClPh	CH2	Single bond	Sub-76
						2-141	Sub-35	3，4-diClPh	CH2	Single bond	Sub-77
2-142	Sub-35	3，4-diClPh	CH2	Single bond	Sub-78
						2-143	Sub-35	3，4-diClPh	CH2	Single bond	Sub-79
2-144	Sub-35	3，4-diClPh	CH2	Single bond	Sub-80
						2-145	Sub-36	3，4-diClPh	CH2	Single bond	Sub-1
2-146	Sub-36	3，4-diClPh	CH2	Single bond	Sub-2
						2-147	Sub-36	3，4-diClPh	CH2	Single bond	Sub-3
2-148	Sub-36	3，4-diClPh	CH2	Single bond	Sub-4
						2-149	Sub-36	3，4-diClPh	CH2	Single bond	Sub-5
2-150	Sub-36	3，4-diClPh	CH2	Single bond	Sub-6
						2-151	Sub-36	3，4-diClPh	CH2	Single bond	Sub-7
2-152	Sub-36	3，4-diClPh	CH2	Single bond	Sub-8
						2-153	Sub-36	3，4-diClPh	CH2	Single bond	Sub-9
2-154	Sub-36	3，4-diClPh	CH2	Single bond	Sub-10
						2-155	Sub-36	3，4-diClPh	CH2	Single bond	Sub-11
2-156	Sub-36	3，4-diClPh	CH2	Single bond	Sub-12

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-157	Sub-36	3，4-diClPh	CH2	Single bond	Sub-13
2-158	Sub-36	3，4-diClPh	CH2	Single bond	Sub-14
						2-159	Sub-36	3，4-diClPh	CH2	Single bond	Sub-15
2-160	Sub-36	3，4-diClPh	CH2	Single bond	Sub-16
						2-161	Sub-36	3，4-diClPh	CH2	Single bond	Sub-17
2-162	Sub-36	3，4-diClPh	CH2	Single bond	Sub-18
						2-163	Sub-36	3，4-diClPh	CH2	Single bond	Sub-19
2-164	Sub-36	3，4-diClPh	CH2	Single bond	Sub-20
						2-165	Sub-36	3，4-diClPh	CH2	Single bond	Sub-21
2-166	Sub-36	3，4-diClPh	CH2	Single bond	Sub-22
						2-167	Sub-36	3，4-diClPh	CH2	Single bond	Sub-23
2-168	Sub-36	3，4-diClPh	CH2	Single bond	Sub-24
						2-169	Sub-36	3，4-diClPh	CH2	Single bond	Sub-25
2-170	Sub-36	3，4-diClPh	CH2	Single bond	Sub-26
						2-171	Sub-36	3，4-diClPh	CH2	Single bond	Sub-27
2-172	Sub-36	3，4-diClPh	CH2	Single bond	Sub-28
						2-173	Sub-36	3，4-diClPh	CH2	Single bond	Sub-29
2-174	Sub-36	3，4-diClPh	CH2	Single bond	Sub-30
						2-175	Sub-36	3，4-diClPh	CH2	Single bond	Sub-31
2-176	Sub-36	3，4-diClPh	CH2	Single bond	Sub-32
						2-177	Sub-36	3，4-diClPh	CH2	Single bond	Sub-65
2-178	Sub-36	3，4-diClPh	CH2	Single bond	Sub-66
						2-179	Sub-36	3，4-diClPh	CH2	Single bond	Sub-67
2-180	Sub-36	3，4-diClPh	CH2	Single bond	Sub-68
						2-181	Sub-36	3，4-diClPh	CH2	Single bond	Sub-69
2-182	Sub-36	3，4-diClPh	CH2	Single bond	Sub-70

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-183	Sub-36	3，4-diClPh	CH2	Single bond	Sub-71
2-184	Sub-36	3，4-diClPh	CH2	Single bond	Sub-72
						2-185	Sub-36	3，4-diClPh	CH2	Single bond	Sub-73
2-186	Sub-36	3，4-diClPh	CH2	Single bond	Sub-74
						2-187	Sub-36	3，4-diClPh	CH2	Single bond	Sub-75
2-188	Sub-36	3，4-diClPh	CH2	Single bond	Sub-76
						2-189	Sub-36	3，4-diClPh	CH2	Single bond	Sub-77
2-190	Sub-36	3，4-diClPh	CH2	Single bond	Sub-78
						2-191	Sub-36	3，4-diClPh	CH2	Single bond	Sub-79
2-192	Sub-36	3，4-diClPh	CH2	Single bond	Sub-80
						2-193	Sub-37	3，4-diClPh	CH2	Single bond	Sub-1
2-194	Sub-37	3，4-diClPh	CH2	Single bond	Sub-2
						2-195	Sub-37	3，4-diClPh	CH2	Single bond	Sub-3
2-196	Sub-37	3，4-diClPh	CH2	Single bond	Sub-4
						2-197	Sub-37	3，4-diClPh	CH2	Single bond	Sub-5
2-198	Sub-37	3，4-diClPh	CH2	Single bond	Sub-6
						2-199	Sub-37	3，4-diClPh	CH2	Single bond	Sub-7
2-200	Sub-37	3，4-diClPh	CH2	Single bond	Sub-8
						2-201	Sub-37	3，4-diClPh	CH2	Single bond	Sub-9
2-202	Sub-37	3，4-diClPh	CH2	Single bond	Sub-10
						2-203	Sub-37	3，4-diClPh	CH2	Single bond	Sub-11
2-204	Sub-37	3，4-diClPh	CH2	Single bond	Sub-12
						2-205	Sub-37	3，4-diClPh	CH2	Single bond	Sub-13
2-206	Sub-37	3，4-diClPh	CH2	Single bond	Sub-14
						2-207	Sub-37	3，4-diClPh	CH2	Single bond	Sub-15
2-208	Sub-37	3，4-diClPh	CH2	Single bond	Sub-16

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-209	Sub-37	3，4-diClPh	CH2	Single bond	Sub-17
2-210	Sub-37	3，4-diClPh	CH2	Single bond	Sub-18
						2-211	Sub-37	3，4-diClPh	CH2	Single bond	Sub-19
2-212	Sub-37	3，4-diClPh	CH2	Single bond	Sub-20
						2-213	Sub-37	3，4-diClPh	CH2	Single bond	Sub-21
2-214	Sub-37	3，4-diClPh	CH2	Single bond	Sub-22
						2-215	Sub-37	3，4-diClPh	CH2	Single bond	Sub-23
2-216	Sub-37	3，4-diClPh	CH2	Single bond	Sub-24
						2-217	Sub-37	3，4-diClPh	CH2	Single bond	Sub-25
2-218	Sub-37	3，4-diClPh	CH2	Single bond	Sub-26
						2-219	Sub-37	3，4-diClPh	CH2	Single bond	Sub-27
2-220	Sub-37	3，4-diClPh	CH2	Single bond	Sub-28
						2-221	Sub-37	3，4-diClPh	CH2	Single bond	Sub-29
2-222	Sub-37	3，4-diClPh	CH2	Single bond	Sub-30
						2-223	Sub-37	3，4-diClPh	CH2	Single bond	Sub-31
2-224	Sub-37	3，4-diClPh	CH2	Single bond	Sub-32
						2-225	Sub-37	3，4-diClPh	CH2	Single bond	Sub-65
2-226	Sub-37	3，4-diClPh	CH2	Single bond	Sub-66
						2-227	Sub-37	3，4-diClPh	CH2	Single bond	Sub-67
2-228	Sub-37	3，4-diClPh	CH2	Single bond	Sub-68
						2-229	Sub-37	3，4-diClPh	CH2	Single bond	Sub-69
2-230	Sub-37	3，4-diClPh	CH2	Single bond	Sub-70
						2-231	Sub-37	3，4-diClPh	CH2	Single bond	Sub-71
2-232	Sub-37	3，4-diClPh	CH2	Single bond	Sub-72
						2-233	Sub-37	3，4-diClPh	CH2	Single bond	Sub-73
2-234	Sub-37	3，4-diClPh	CH2	Single bond	Sub-74

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-235	Sub-37	3，4-diClPh	CH2	Single bond	Sub-75
2-236	Sub-37	3，4-diClPh	CH2	Single bond	Sub-76
						2-237	Sub-37	3，4-diClPh	CH2	Single bond	Sub-77
2-238	Sub-37	3，4-diClPh	CH2	Single bond	Sub-78
						2-239	Sub-37	3，4-diClPh	CH2	Single bond	Sub-79
2-240	Sub-37	3，4-diClPh	CH2	Single bond	Sub-80
						2-241	Sub-38	3，4-diClPh	CH2	Single bond	Sub-1
2-242	Sub-38	3，4-diClPh	CH2	Single bond	Sub-2
						2-243	Sub-38	3，4-diClPh	CH2	Single bond	Sub-3
2-244	Sub-38	3，4-diClPh	CH2	Single bond	Sub-4
						2-245	Sub-38	3，4-diClPh	CH2	Single bond	Sub-5
2-246	Sub-38	3，4-diClPh	CH2	Single bond	Sub-6
						2-247	Sub-38	3，4-diClPh	CH2	Single bond	Sub-7
2-248	Sub-38	3，4-diClPh	CH2	Single bond	Sub-8
						2-249	Sub-38	3，4-diClPh	CH2	Single bond	Sub-9
2-250	Sub-38	3，4-diClPh	CH2	Single bond	Sub-10
						2-251	Sub-38	3，4-diClPh	CH2	Single bond	Sub-11
2-252	Sub-38	3，4-diClPh	CH2	Single bond	Sub-12
						2-253	Sub-38	3，4-diClPh	CH2	Single bond	Sub-13
2-254	Sub-38	3，4-diClPh	CH2	Single bond	Sub-14
						2-255	Sub-38	3，4-diClPh	CH2	Single bond	Sub-15
2-256	Sub-38	3，4-diClPh	CH2	Single bond	Sub-16
						2-257	Sub-38	3，4-diClPh	CH2	Single bond	Sub-17
2-258	Sub-38	3，4-diClPh	CH2	Single bond	Sub-18
						2-259	Sub-38	3，4-diClPh	CH2	Single bond	Sub-19
2-260	Sub-38	3，4-diClPh	CH2	Single bond	Sub-20

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-261	Sub-38	3，4-diClPh	CH2	Single bond	Sub-21
2-262	Sub-38	3，4-diClPh	CH2	Single bond	Sub-22
						2-263	Sub-38	3，4-diClPh	CH2	Single bond	Sub-23
2-264	Sub-38	3，4-diClPh	CH2	Single bond	Sub-24
						2-265	Sub-38	3，4-diClPh	CH2	Single bond	Sub-25
2-266	Sub-38	3，4-diClPh	CH2	Single bond	Sub-26
						2-267	Sub-38	3，4-diClPh	CH2	Single bond	Sub-27
2-268	Sub-38	3，4-diClPh	CH2	Single bond	Sub-28
						2-269	Sub-38	3，4-diClPh	CH2	Single bond	Sub-29
2-270	Sub-38	3，4-diClPh	CH2	Single bond	Sub-30
						2-271	Sub-38	3，4-diClPh	CH2	Single bond	Sub-31
2-272	Sub-38	3，4-diClPh	CH2	Single bond	Sub-32
						2-273	Sub-38	3，4-diClPh	CH2	Single bond	Sub-65
2-274	Sub-38	3，4-diClPh	CH2	Single bond	Sub-66
						2-275	Sub-38	3，4-diClPh	CH2	Single bond	Sub-67
2-276	Sub-38	3，4-diClPh	CH2	Single bond	Sub-68
						2-277	Sub-38	3，4-diClPh	CH2	Single bond	Sub-69
2-278	Sub-38	3，4-diClPh	CH2	Single bond	Sub-70
						2-279	Sub-38	3，4-diClPh	CH2	Single bond	Sub-71
2-280	Sub-38	3，4-diClPh	CH2	Single bond	Sub-72
						2-281	Sub-38	3，4-diClPh	CH2	Single bond	Sub-73
2-282	Sub-38	3，4-diClPh	CH2	Single bond	Sub-74
						2-283	Sub-38	3，4-diClPh	CH2	Single bond	Sub-75
2-284	Sub-38	3，4-diClPh	CH2	Single bond	Sub-76
						2-285	Sub-38	3，4-diClPh	CH2	Single bond	Sub-77
2-286	Sub-38	3，4-diClPh	CH2	Single bond	Sub-78

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-287	Sub-38	3，4-diClPh	CH2	Single bond	Sub-79
2-288	Sub-38	3，4-diClPh	CH2	Single bond	Sub-80
						2-289	Sub-39	3，4-diClPh	CH2	Single bond	Sub-1
2-290	Sub-39	3，4-diClPh	CH2	Single bond	Sub-2
						2-291	Sub-39	3，4-diClPh	CH2	Single bond	Sub-3
2-292	Sub-39	3，4-diClPh	CH2	Single bond	Sub-4
						2-293	Sub-39	3，4-diClPh	CH2	Single bond	Sub-5
2-294	Sub-39	3，4-diClPh	CH2	Single bond	Sub-6
						2-295	Sub-39	3，4-diClPh	CH2	Single bond	Sub-7
2-296	Sub-39	3，4-diClPh	CH2	Single bond	Sub-8
						2-297	Sub-39	3，4-diClPh	CH2	Single bond	Sub-9
2-298	Sub-39	3，4-diClPh	CH2	Single bond	Sub-10
						2-299	Sub-39	3，4-diClPh	CH2	Single bond	Sub-11
2-300	Sub-39	3，4-diClPh	CH2	Single bond	Sub-12
						2-301	Sub-39	3，4-diClPh	CH2	Single bond	Sub-13
2-302	Sub-39	3，4-diClPh	CH2	Single bond	Sub-14
						2-303	Sub-39	3，4-diClPh	CH2	Single bond	Sub-15
2-304	Sub-39	3，4-diClPh	CH2	Single bond	Sub-16
						2-305	Sub-39	3，4-diClPh	CH2	Single bond	Sub-17
2-306	Sub-39	3，4-diClPh	CH2	Single bond	Sub-18
						2-307	Sub-39	3，4-diClPh	CH2	Single bond	Sub-19
2-308	Sub-39	3，4-diClPh	CH2	Single bond	Sub-20
						2-309	Sub-39	3，4-diClPh	CH2	Single bond	Sub-21
2-310	Sub-39	3，4-diClPh	CH2	Single bond	Sub-22
						2-311	Sub-39	3，4-diClPh	CH2	Single bond	Sub-23
2-312	Sub-39	3，4-diClPh	CH2	Single bond	Sub-24

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-313	Sub-39	3，4-diClPh	CH2	Single bond	Sub-25
2-314	Sub-39	3，4-diClPh	CH2	Single bond	Sub-26
						2-315	Sub-39	3，4-diClPh	CH2	Single bond	Sub-27
2-316	Sub-39	3，4-diClPh	CH2	Single bond	Sub-28
						2-317	Sub-39	3，4-diClPh	CH2	Single bond	Sub-29
2-318	Sub-39	3，4-diClPh	CH2	Single bond	Sub-30
						2-319	Sub-39	3，4-diClPh	CH2	Single bond	Sub-31
2-320	Sub-39	3，4-diClPh	CH2	Single bond	Sub-32
						2-321	Sub-39	3，4-diClPh	CH2	Single bond	Sub-65
2-322	Sub-39	3，4-diClPh	CH2	Single bond	Sub-66
						2-323	Sub-39	3，4-diClPh	CH2	Single bond	Sub-67
2-324	Sub-39	3，4-diClPh	CH2	Single bond	Sub-68
						2-325	Sub-39	3，4-diClPh	CH2	Single bond	Sub-69
2-326	Sub-39	3，4-diClPh	CH2	Single bond	Sub-70
						2-327	Sub-39	3，4-diClPh	CH2	Single bond	Sub-71
2-328	Sub-39	3，4-diClPh	CH2	Single bond	Sub-72
						2-329	Sub-39	3，4-diClPh	CH2	Single bond	Sub-73
2-330	Sub-39	3，4-diClPh	CH2	Single bond	Sub-74
						2-331	Sub-39	3，4-diClPh	CH2	Single bond	Sub-75
2-332	Sub-39	3，4-diClPh	CH2	Single bond	Sub-76
						2-333	Sub-39	3，4-diClPh	CH2	Single bond	Sub-77
2-334	Sub-39	3，4-diClPh	CH2	Single bond	Sub-78
						2-335	Sub-39	3，4-diClPh	CH2	Single bond	Sub-79
2-336	Sub-39	3，4-diClPh	CH2	Single bond	Sub-80
						2-337	Sub-40	3，4-diClPh	CH2	Single bond	Sub-1
2-338	Sub-40	3，4-diClPh	CH2	Single bond	Sub-2

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-339	Sub-40	3，4-diClPh	CH2	Single bond	Sub-3
2-340	Sub-40	3，4-diClPh	CH2	Single bond	Sub-4
						2-341	Sub-40	3，4-diClPh	CH2	Single bond	Sub-5
2-342	Sub-40	3，4-diClPh	CH2	Single bond	Sub-6
						2-343	Sub-40	3，4-diClPh	CH2	Single bond	Sub-7
2-344	Sub-40	3，4-diClPh	CH2	Single bond	Sub-8
						2-345	Sub-40	3，4-diClPh	CH2	Single bond	Sub-9
2-346	Sub-40	3，4-diClPh	CH2	Single bond	Sub-10
						2-347	Sub-40	3，4-diClPh	CH2	Single bond	Sub-11
2-348	Sub-40	3，4-diClPh	CH2	Single bond	Sub-12
						2-349	Sub-40	3，4-diClPh	CH2	Single bond	Sub-13
2-350	Sub-40	3，4-diClPh	CH2	Single bond	Sub-14
						2-351	Sub-40	3，4-diClPh	CH2	Single bond	Sub-15
2-352	Sub-40	3，4-diClPh	CH2	Single bond	Sub-16
						2-353	Sub-40	3，4-diClPh	CH2	Single bond	Sub-17
2-354	Sub-40	3，4-diClPh	CH2	Single bond	Sub-18
						2-355	Sub-40	3，4-diClPh	CH2	Single bond	Sub-19
2-356	Sub-40	3，4-diClPh	CH2	Single bond	Sub-20
						2-357	Sub-40	3，4-diClPh	CH2	Single bond	Sub-21
2-358	Sub-40	3，4-diClPh	CH2	Single bond	Sub-22
						2-359	Sub-40	3，4-diClPh	CH2	Single bond	Sub-23
2-360	Sub-40	3，4-diClPh	CH2	Single bond	Sub-24
						2-361	Sub-40	3，4-diClPh	CH2	Single bond	Sub-25
2-362	Sub-40	3，4-diClPh	CH2	Single bond	Sub-26
						2-363	Sub-40	3，4-diClPh	CH2	Single bond	Sub-27
2-364	Sub-40	3，4-diClPh	CH2	Single bond	Sub-28

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-365	Sub-40	3，4-diClPh	CH2	Single bond	Sub-29
2-366	Sub-40	3，4-diClPh	CH2	Single bond	Sub-30
						2-367	Sub-40	3，4-diClPh	CH2	Single bond	Sub-31
2-368	Sub-40	3，4-diClPh	CH2	Single bond	Sub-32
						2-369	Sub-40	3，4-diClPh	CH2	Single bond	Sub-65
2-370	Sub-40	3，4-diClPh	CH2	Single bond	Sub-66
						2-371	Sub-40	3，4-diClPh	CH2	Single bond	Sub-67
2-372	Sub-40	3，4-diClPh	CH2	Single bond	Sub-68
						2-373	Sub-40	3，4-diClPh	CH2	Single bond	Sub-69
2-374	Sub-40	3，4-diClPh	CH2	Single bond	Sub-70
						2-375	Sub-40	3，4-diClPh	CH2	Single bond	Sub-71
2-376	Sub-40	3，4-diClPh	CH2	Single bond	Sub-72
						2-377	Sub-40	3，4-diClPh	CH2	Single bond	Sub-73
2-378	Sub-40	3，4-diClPh	CH2	Single bond	Sub-74
						2-379	Sub-40	3，4-diClPh	CH2	Single bond	Sub-75
2-380	Sub-40	3，4-diClPh	CH2	Single bond	Sub-76
						2-381	Sub-40	3，4-diClPh	CH2	Single bond	Sub-77
2-382	Sub-40	3，4-diClPh	CH2	Single bond	Sub-78
						2-383	Sub-40	3，4-diClPh	CH2	Single bond	Sub-79
2-384	Sub-40	3，4-diClPh	CH2	Single bond	Sub-80
						2-385	Sub-41	3，4-diClPh	CH2	Single bond	Sub-1
2-386	Sub-41	3，4-diClPh	CH2	Single bond	Sub-2
						2-387	Sub-41	3，4-diClPh	CH2	Single bond	Sub-3
2-388	Sub-41	3，4-diClPh	CH2	Single bond	Sub-4
						2-389	Sub-41	3，4-diClPh	CH2	Single bond	Sub-5
2-390	Sub-41	3，4-diClPh	CH2	Single bond	Sub-6

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-391	Sub-41	3，4-diClPh	CH2	Single bond	Sub-7
2-392	Sub-41	3，4-diClPh	CH2	Single bond	Sub-8
						2-393	Sub-41	3，4-diClPh	CH2	Single bond	Sub-9
2-394	Sub-41	3，4-diClPh	CH2	Single bond	Sub-10
						2-395	Sub-41	3，4-diClPh	CH2	Single bond	Sub-11
2-396	Sub-41	3，4-diClPh	CH2	Single bond	Sub-12
						2-397	Sub-41	3，4-diClPh	CH2	Single bond	Sub-13
2-398	Sub-41	3，4-diClPh	CH2	Single bond	Sub-14
						2-399	Sub-41	3，4-diClPh	CH2	Single bond	Sub-15
2-400	Sub-41	3，4-diClPh	CH2	Single bond	Sub-16
						2-401	Sub-41	3，4-diClPh	CH2	Single bond	Sub-17
2-402	Sub-41	3，4-diClPh	CH2	Single bond	Sub-18
						2-403	Sub-41	3，4-diClPh	CH2	Single bond	Sub-19
2-404	Sub-41	3，4-diClPh	CH2	Single bond	Sub-20
						2-405	Sub-41	3，4-diClPh	CH2	Single bond	Sub-21
2-406	Sub-41	3，4-diClPh	CH2	Single bond	Sub-22
						2-407	Sub-41	3，4-diClPh	CH2	Single bond	Sub-23
2-408	Sub-41	3，4-diClPh	CH2	Single bond	Sub-24
						2-409	Sub-41	3，4-diClPh	CH2	Single bond	Sub-25
2-410	Sub-41	3，4-diClPh	CH2	Single bond	Sub-26
						2-411	Sub-41	3，4-diClPh	CH2	Single bond	Sub-27
2-412	Sub-41	3，4-diClPh	CH2	Single bond	Sub-28
						2-413	Sub-41	3，4-diClPh	CH2	Single bond	Sub-29
2-414	Sub-41	3，4-diClPh	CH2	Single bond	Sub-30
						2-415	Sub-41	3，4-diClPh	CH2	Single bond	Sub-31
2-416	Sub-41	3，4-diClPh	CH2	Single bond	Sub-32

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-417	Sub-41	3，4-diClPh	CH2	Single bond	Sub-65
2-418	Sub-41	3，4-diClPh	CH2	Single bond	Sub-66
						2-419	Sub-41	3，4-diClPh	CH2	Single bond	Sub-67
2-420	Sub-41	3，4-diClPh	CH2	Single bond	Sub-68
						2-421	Sub-41	3，4-diClPh	CH2	Single bond	Sub-69
2-422	Sub-41	3，4-diClPh	CH2	Single bond	Sub-70
						2-423	Sub-41	3，4-diClPh	CH2	Single bond	Sub-71
2-424	Sub-41	3，4-diClPh	CH2	Single bond	Sub-72
						2-425	Sub-41	3，4-diClPh	CH2	Single bond	Sub-73
2-426	Sub-41	3，4-diClPh	CH2	Single bond	Sub-74
						2-427	Sub-41	3，4-diClPh	CH2	Single bond	Sub-75
2-428	Sub-41	3，4-diClPh	CH2	Single bond	Sub-76
						2-429	Sub-41	3，4-diClPh	CH2	Single bond	Sub-77
2-430	Sub-41	3，4-diClPh	CH2	Single bond	Sub-78
						2-431	Sub-41	3，4-diClPh	CH2	Single bond	Sub-79
2-432	Sub-41	3，4-diClPh	CH2	Single bond	Sub-80
						2-433	Sub-42	3，4-diClPh	CH2	Single bond	Sub-1
2-434	Sub-42	3，4-diClPh	CH2	Single bond	Sub-2
						2-435	Sub-42	3，4-diClPh	CH2	Single bond	Sub-3
2-436	Sub-42	3，4-diClPh	CH2	Single bond	Sub-4
						2-437	Sub-42	3，4-diClPh	CH2	Single bond	Sub-5
2-438	Sub-42	3，4-diClPh	CH2	Single bond	Sub-6
						2-439	Sub-42	3，4-diClPh	CH2	Single bond	Sub-7
2-440	Sub-42	3，4-diClPh	CH2	Single bond	Sub-8
						2-441	Sub-42	3，4-diClPh	CH2	Single bond	Sub-9
2-442	Sub-42	3，4-diClPh	CH2	Single bond	Sub-10

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-443	Sub-42	3，4-diClPh	CH2	Single bond	Sub-11
2-444	Sub-42	3，4-diClPh	CH2	Single bond	Sub-12
						2-445	Sub-42	3，4-diClPh	CH2	Single bond	Sub-13
2-446	Sub-42	3，4-diClPh	CH2	Single bond	Sub-14
						2-447	Sub-42	3，4-diClPh	CH2	Single bond	Sub-15
2-448	Sub-42	3，4-diClPh	CH2	Single bond	Sub-16
						2-449	Sub-42	3，4-diClPh	CH2	Single bond	Sub-17
2-450	Sub-42	3，4-diClPh	CH2	Single bond	Sub-18
						2-451	Sub-42	3，4-diClPh	CH2	Single bond	Sub-19
2-452	Sub-42	3，4-diClPh	CH2	Single bond	Sub-20
						2-453	Sub-42	3，4-diClPh	CH2	Single bond	Sub-21
2-454	Sub-42	3，4-diClPh	CH2	Single bond	Sub-22
						2-455	Sub-42	3，4-diClPh	CH2	Single bond	Sub-23
2-456	Sub-42	3，4-diClPh	CH2	Single bond	Sub-24
						2-457	Sub-42	3，4-diClPh	CH2	Single bond	Sub-25
2-458	Sub-42	3，4-diClPh	CH2	Single bond	Sub-26
						2-459	Sub-42	3，4-diClPh	CH2	Single bond	Sub-27
2-460	Sub-42	3，4-diClPh	CH2	Single bond	Sub-28
						2-461	Sub-42	3，4-diClPh	CH2	Single bond	Sub-29
2-462	Sub-42	3，4-diClPh	CH2	Single bond	Sub-30
						2-463	Sub-42	3，4-diClPh	CH2	Single bond	Sub-31
2-464	Sub-42	3，4-diClPh	CH2	Single bond	Sub-32
						2-465	Sub-42	3，4-diClPh	CH2	Single bond	Sub-65
2-466	Sub-42	3，4-diClPh	CH2	Single bond	Sub-66
						2-467	Sub-42	3，4-diClPh	CH2	Single bond	Sub-67
2-468	Sub-42	3，4-diClPh	CH2	Single bond	Sub-68

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-469	Sub-42	3，4-diClPh	CH2	Single bond	Sub-69
2-470	Sub-42	3，4-diClPh	CH2	Single bond	Sub-70
						2-471	Sub-42	3，4-diClPh	CH2	Single bond	Sub-71
2-472	Sub-42	3，4-diClPh	CH2	Single bond	Sub-72
						2-473	Sub-42	3，4-diClPh	CH2	Single bond	Sub-73
2-474	Sub-42	3，4-diClPh	CH2	Single bond	Sub-74
						2-475	Sub-42	3，4-diClPh	CH2	Single bond	Sub-75
2-476	Sub-42	3，4-diClPh	CH2	Single bond	Sub-76
						2-477	Sub-42	3，4-diClPh	CH2	Single bond	Sub-77
2-478	Sub-42	3，4-diClPh	CH2	Single bond	Sub-78
						2-479	Sub-42	3，4-diClPh	CH2	Single bond	Sub-79
2-480	Sub-42	3，4-diClPh	CH2	Single bond	Sub-80
						2-481	Sub-43	3，4-diClPh	CH2	Single bond	Sub-1
2-482	Sub-43	3，4-diClPh	CH2	Single bond	Sub-2
						2-483	Sub-43	3，4-diClPh	CH2	Single bond	Sub-3
2-484	Sub-43	3，4-diClPh	CH2	Single bond	Sub-4
						2-485	Sub-43	3，4-diClPh	CH2	Single bond	Sub-5
2-486	Sub-43	3，4-diClPh	CH2	Single bond	Sub-6
						2-487	Sub-43	3，4-diClPh	CH2	Single bond	Sub-7
2-488	Sub-43	3，4-diClPh	CH2	Single bond	Sub-8
						2-489	Sub-43	3，4-diClPh	CH2	Single bond	Sub-9
2-490	Sub-43	3，4-diClPh	CH2	Single bond	Sub-10
						2-491	Sub-43	3，4-diClPh	CH2	Single bond	Sub-11
2-492	Sub-43	3，4-diClPh	CH2	Single bond	Sub-12
						2-493	Sub-43	3，4-diClPh	CH2	Single bond	Sub-13
2-494	Sub-43	3，4-diClPh	CH2	Single bond	Sub-14

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-495	Sub-43	3，4-diClPh	CH2	Single bond	Sub-15
2-496	Sub-43	3，4-diClPh	CH2	Single bond	Sub-16
						2-497	Sub-43	3，4-diClPh	CH2	Single bond	Sub-17
2-498	Sub-43	3，4-diClPh	CH2	Single bond	Sub-18
						2-499	Sub-43	3，4-diClPh	CH2	Single bond	Sub-19
2-500	Sub-43	3，4-diClPh	CH2	Single bond	Sub-20
						2-501	Sub-43	3，4-diClPh	CH2	Single bond	Sub-21
2-502	Sub-43	3，4-diClPh	CH2	Single bond	Sub-22
						2-503	Sub-43	3，4-diClPh	CH2	Single bond	Sub-23
2-504	Sub-43	3，4-diClPh	CH2	Single bond	Sub-24
						2-505	Sub-43	3，4-diClPh	CH2	Single bond	Sub-25
2-506	Sub-43	3，4-diClPh	CH2	Single bond	Sub-26
						2-507	Sub-43	3，4-diClPh	CH2	Single bond	Sub-27
2-508	Sub-43	3，4-diClPh	CH2	Single bond	Sub-28
						2-509	Sub-43	3，4-diClPh	CH2	Single bond	Sub-29
2-510	Sub-43	3，4-diClPh	CH2	Single bond	Sub-30
						2-511	Sub-43	3，4-diClPh	CH2	Single bond	Sub-31
2-512	Sub-43	3，4-diClPh	CH2	Single bond	Sub-32
						2-513	Sub-43	3，4-diClPh	CH2	Single bond	Sub-65
2-514	Sub-43	3，4-diClPh	CH2	Single bond	Sub-66
						2-515	Sub-43	3，4-diClPh	CH2	Single bond	Sub-67
2-516	Sub-43	3，4-diClPh	CH2	Single bond	Sub-68
						2-517	Sub-43	3，4-diClPh	CH2	Single bond	Sub-69
2-518	Sub-43	3，4-diClPh	CH2	Single bond	Sub-70
						2-519	Sub-43	3，4-diClPh	CH2	Single bond	Sub-71
2-520	Sub-43	3，4-diClPh	CH2	Single bond	Sub-72

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-521	Sub-43	3，4-diClPh	CH2	Single bond	Sub-73
2-522	Sub-43	3，4-diClPh	CH2	Single bond	Sub-74
						2-523	Sub-43	3，4-diClPh	CH2	Single bond	Sub-75
2-524	Sub-43	3，4-diClPh	CH2	Single bond	Sub-76
						2-525	Sub-43	3，4-diClPh	CH2	Single bond	Sub-77
2-526	Sub-43	3，4-diClPh	CH2	Single bond	Sub-78
						2-527	Sub-43	3，4-diClPh	CH2	Single bond	Sub-79
2-528	Sub-43	3，4-diClPh	CH2	Single bond	Sub-80
						2-529	Sub-44	3，4-diClPh	CH2	Single bond	Sub-1
2-530	Sub-44	3，4-diClPh	CH2	Single bond	Sub-2
						2-531	Sub-44	3，4-diClPh	CH2	Single bond	Sub-3
2-532	Sub-44	3，4-diClPh	CH2	Single bond	Sub-4
						2-533	Sub-44	3，4-diClPh	CH2	Single bond	Sub-5
2-534	Sub-44	3，4-diClPh	CH2	Single bond	Sub-6
						2-535	Sub-44	3，4-diClPh	CH2	Single bond	Sub-7
2-536	Sub-44	3，4-diClPh	CH2	Single bond	Sub-8
						2-537	Sub-44	3，4-diClPh	CH2	Single bond	Sub-9
2-538	Sub-44	3，4-diClPh	CH2	Single bond	Sub-10
						2-539	Sub-44	3，4-diClPh	CH2	Single bond	Sub-11
2-540	Sub-44	3，4-diClPh	CH2	Single bond	Sub-12
						2-541	Sub-44	3，4-diClPh	CH2	Single bond	Sub-13
2-542	Sub-44	3，4-diClPh	CH2	Single bond	Sub-14
						2-543	Sub-44	3，4-diClPh	CH2	Single bond	Sub-15
2-544	Sub-44	3，4-diClPh	CH2	Single bond	Sub-16
						2-545	Sub-44	3，4-diClPh	CH2	Single bond	Sub-17
2-546	Sub-44	3，4-diClPh	CH2	Single bond	Sub-18

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-547	Sub-44	3，4-diClPh	CH2	Single bond	Sub-19
2-548	Sub-44	3，4-diClPh	CH2	Single bond	Sub-20
						2-549	Sub-44	3，4-diClPh	CH2	Single bond	Sub-21
2-550	Sub-44	3，4-diClPh	CH2	Single bond	Sub-22
						2-551	Sub-44	3，4-diClPh	CH2	Single bond	Sub-23
2-552	Sub-44	3，4-diClPh	CH2	Single bond	Sub-24
						2-553	Sub-44	3，4-diClPh	CH2	Single bond	Sub-25
2-554	Sub-44	3，4-diClPh	CH2	Single bond	Sub-26
						2-555	Sub-44	3，4-diClPh	CH2	Single bond	Sub-27
2-556	Sub-44	3，4-diClPh	CH2	Single bond	Sub-28
						2-557	Sub-44	3，4-diClPh	CH2	Single bond	Sub-29
2-558	Sub-44	3，4-diClPh	CH2	Single bond	Sub-30
						2-559	Sub-44	3，4-diClPh	CH2	Single bond	Sub-31
2-560	Sub-44	3，4-diClPh	CH2	Single bond	Sub-32
						2-561	Sub-44	3，4-diClPh	CH2	Single bond	Sub-65
2-562	Sub-44	3，4-diClPh	CH2	Single bond	Sub-66
						2-563	Sub-44	3，4-diClPh	CH2	Single bond	Sub-67
2-564	Sub-44	3，4-diClPh	CH2	Single bond	Sub-68
						2-565	Sub-44	3，4-diClPh	CH2	Single bond	Sub-69
2-566	Sub-44	3，4-diClPh	CH2	Single bond	Sub-70
						2-567	Sub-44	3，4-diClPh	CH2	Single bond	Sub-71
2-568	Sub-44	3，4-diClPh	CH2	Single bond	Sub-72
						2-569	Sub-44	3，4-diClPh	CH2	Single bond	Sub-73
2-570	Sub-44	3，4-diClPh	CH2	Single bond	Sub-74
						2-571	Sub-44	3，4-diClPh	CH2	Single bond	Sub-75
2-572	Sub-44	3，4-diClPh	CH2	Single bond	Sub-76

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-573	Sub-44	3，4-diClPh	CH2	Single bond	Sub-77
2-574	Sub-44	3，4-diClPh	CH2	Single bond	Sub-78
						2-575	Sub-44	3，4-diClPh	CH2	Single bond	Sub-79
2-576	Sub-44	3，4-diClPh	CH2	Single bond	Sub-80
						2-577	Sub-45	3，4-diClPh	CH2	Single bond	Sub-1
2-578	Sub-45	3，4-diClPh	CH2	Single bond	Sub-2
						2-579	Sub-45	3，4-diClPh	CH2	Single bond	Sub-3
2-580	Sub-45	3，4-diClPh	CH2	Single bond	Sub-4
						2-581	Sub-45	3，4-diClPh	CH2	Single bond	Sub-5
2-582	Sub-45	3，4-diClPh	CH2	Single bond	Sub-6
						2-583	Sub-45	3，4-diClPh	CH2	Single bond	Sub-7
2-584	Sub-45	3，4-diClPh	CH2	Single bond	Sub-8
						2-585	Sub-45	3，4-diClPh	CH2	Single bond	Sub-9
2-586	Sub-45	3，4-diClPh	CH2	Single bond	Sub-10
						2-587	Sub-45	3，4-diClPh	CH2	Single bond	Sub-11
2-588	Sub-45	3，4-diClPh	CH2	Single bond	Sub-12
						2-589	Sub-45	3，4-diClPh	CH2	Single bond	Sub-13
2-590	Sub-45	3，4-diClPh	CH2	Single bond	Sub-14
						2-591	Sub-45	3，4-diClPh	CH2	Single bond	Sub-15
2-592	Sub-45	3，4-diClPh	CH2	Single bond	Sub-16
						2-593	Sub-45	3，4-diClPh	CH2	Single bond	Sub-17
2-594	Sub-45	3，4-diClPh	CH2	Single bond	Sub-18
						2-595	Sub-45	3，4-diClPh	CH2	Single bond	Sub-19
2-596	Sub-45	3，4-diClPh	CH2	Single bond	Sub-20
						2-597	Sub-45	3，4-diClPh	CH2	Single bond	Sub-21
2-598	Sub-45	3，4-diClPh	CH2	Single bond	Sub-22

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-599	Sub-45	3，4-diClPh	CH2	Single bond	Sub-23
2-600	Sub-45	3，4-diClPh	CH2	Single bond	Sub-24
						2-601	Sub-45	3，4-diClPh	CH2	Single bond	Sub-25
2-602	Sub-45	3，4-diClPh	CH2	Single bond	Sub-26
						2-603	Sub-45	3，4-diClPh	CH2	Single bond	Sub-27
2-604	Sub-45	3，4-diClPh	CH2	Single bond	Sub-28
						2-605	Sub-45	3，4-diClPh	CH2	Single bond	Sub-29
2-606	Sub-45	3，4-diClPh	CH2	Single bond	Sub-30
						2-607	Sub-45	3，4-diClPh	CH2	Single bond	Sub-31
2-608	Sub-45	3，4-diClPh	CH2	Single bond	Sub-32
						2-609	Sub-45	3，4-diClPh	CH2	Single bond	Sub-65
2-610	Sub-45	3，4-diClPh	CH2	Single bond	Sub-66
						2-611	Sub-45	3，4-diClPh	CH2	Single bond	Sub-67
2-612	Sub-45	3，4-diClPh	CH2	Single bond	Sub-68
						2-613	Sub-45	3，4-diClPh	CH2	Single bond	Sub-69
2-614	Sub-45	3，4-diClPh	CH2	Single bond	Sub-70
						2-615	Sub-45	3，4-diClPh	CH2	Single bond	Sub-71
2-616	Sub-45	3，4-diClPh	CH2	Single bond	Sub-72
						2-617	Sub-45	3，4-diClPh	CH2	Single bond	Sub-73
2-618	Sub-45	3，4-diClPh	CH2	Single bond	Sub-74
						2-619	Sub-45	3，4-diClPh	CH2	Single bond	Sub-75
2-620	Sub-45	3，4-diClPh	CH2	Single bond	Sub-76
						2-621	Sub-45	3，4-diClPh	CH2	Single bond	Sub-77
2-622	Sub-45	3，4-diClPh	CH2	Single bond	Sub-78
						2-623	Sub-45	3，4-diClPh	CH2	Single bond	Sub-79
2-624	Sub-45	3，4-diClPh	CH2	Single bond	Sub-80

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-625	Sub-46	3，4-diClPh	CH2	Single bond	Sub-1
2-626	Sub-46	3，4-diClPh	CH2	Single bond	Sub-2
						2-627	Sub-46	3，4-diClPh	CH2	Single bond	Sub-3
2-628	Sub-46	3，4-diClPh	CH2	Single bond	Sub-4
						2-629	Sub-46	3，4-diClPh	CH2	Single bond	Sub-5
2-630	Sub-46	3，4-diClPh	CH2	Single bond	Sub-6
						2-631	Sub-46	3，4-diClPh	CH2	Single bond	Sub-7
2-632	Sub-46	3，4-diClPh	CH2	Single bond	Sub-8
						2-633	Sub-46	3，4-diClPh	CH2	Single bond	Sub-9
2-634	Sub-46	3，4-diClPh	CH2	Single bond	Sub-10
						2-635	Sub-46	3，4-diClPh	CH2	Single bond	Sub-11
2-636	Sub-46	3，4-diClPh	CH2	Single bond	Sub-12
						2-637	Sub-46	3，4-diClPh	CH2	Single bond	Sub-13
2-638	Sub-46	3，4-diClPh	CH2	Single bond	Sub-14
						2-639	Sub-46	3，4-diClPh	CH2	Single bond	Sub-15
2-640	Sub-46	3，4-diClPh	CH2	Single bond	Sub-16
						2-641	Sub-46	3，4-diClPh	CH2	Single bond	Sub-17
2-642	Sub-46	3，4-diClPh	CH2	Single bond	Sub-18
						2-643	Sub-46	3，4-diClPh	CH2	Single bond	Sub-19
2-644	Sub-46	3，4-diClPh	CH2	Single bond	Sub-20
						2-645	Sub-46	3，4-diClPh	CH2	Single bond	Sub-21
2-646	Sub-46	3，4-diClPh	CH2	Single bond	Sub-22
						2-647	Sub-46	3，4-diClPh	CH2	Single bond	Sub-23
2-648	Sub-46	3，4-diClPh	CH2	Single bond	Sub-24
						2-649	Sub-46	3，4-diClPh	CH2	Single bond	Sub-25
2-650	Sub-46	3，4-diClPh	CH2	Single bond	Sub-26

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-651	Sub-46	3，4-diClPh	CH2	Single bond	Sub-27
2-652	Sub-46	3，4-diClPh	CH2	Single bond	Sub-28
						2-653	Sub-46	3，4-diClPh	CH2	Single bond	Sub-29
2-654	Sub-46	3，4-diClPh	CH2	Single bond	Sub-30
						2-655	Sub-46	3，4-diClPh	CH2	Single bond	Sub-31
2-656	Sub-46	3，4-diClPh	CH2	Single bond	Sub-32
						2-657	Sub-46	3，4-diClPh	CH2	Single bond	Sub-65
2-658	Sub-46	3，4-diClPh	CH2	Single bond	Sub-66
						2-659	Sub-46	3，4-diClPh	CH2	Single bond	Sub-67
2-660	Sub-46	3，4-diClPh	CH2	Single bond	Sub-68
						2-661	Sub-46	3，4-diClPh	CH2	Single bond	Sub-69
2-662	Sub-46	3，4-diClPh	CH2	Single bond	Sub-70
						2-663	Sub-46	3，4-diClPh	CH2	Single bond	Sub-71
2-664	Sub-46	3，4-diClPh	CH2	Single bond	Sub-72
						2-665	Sub-46	3，4-diClPh	CH2	Single bond	Sub-73
2-666	Sub-46	3，4-diClPh	CH2	Single bond	Sub-74
						2-667	Sub-46	3，4-diClPh	CH2	Single bond	Sub-75
2-668	Sub-46	3，4-diClPh	CH2	Single bond	Sub-76
						2-669	Sub-46	3，4-diClPh	CH2	Single bond	Sub-77
2-670	Sub-46	3，4-diClPh	CH2	Single bond	Sub-78
						2-671	Sub-46	3，4-diClPh	CH2	Single bond	Sub-79
2-672	Sub-46	3，4-diClPh	CH2	Single bond	Sub-80
						2-673	Sub-47	3，4-diClPh	CH2	Single bond	Sub-1
2-674	Sub-47	3，4-diClPh	CH2	Single bond	Sub-2
						2-675	Sub-47	3，4-diClPh	CH2	Single bond	Sub-3
2-676	Sub-47	3，4-diClPh	CH2	Single bond	Sub-4

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-677	Sub-47	3，4-diClPh	CH2	Single bond	Sub-5
2-678	Sub-47	3，4-diClPh	CH2	Single bond	Sub-6
						2-679	Sub-47	3，4-diClPh	CH2	Single bond	Sub-7
2-680	Sub-47	3，4-diClPh	CH2	Single bond	Sub-8
						2-681	Sub-47	3，4-diClPh	CH2	Single bond	Sub-9
2-682	Sub-47	3，4-diClPh	CH2	Single bond	Sub-10
						2-683	Sub-47	3，4-diClPh	CH2	Single bond	Sub-11
2-684	Sub-47	3，4-diClPh	CH2	SheetKey with a key body	Sub-12
						2-685	Sub-47	3，4-diClPh	CH2	Single bond	Sub-13
2-686	Sub-47	3，4-diClPh	CH2	Single bond	Sub-14
						2-687	Sub-47	3，4-diClPh	CH2	Single bond	Sub-15
2-688	Sub-47	3，4-diClPh	CH2	Single bond	Sub-16
						2-689	Sub-47	3，4-diClPh	CH2	Single bond	Sub-17
2-690	Sub-47	3，4-diClPh	CH2	Single bond	Sub-18
						2-691	Sub-47	3，4-diClPh	CH2	Single bond	Sub-19
2-692	Sub-47	3，4-diClPh	CH2	Single bond	Sub-20
						2-693	Sub-47	3，4-diClPh	CH2	Single bond	Sub-21
2-694	Sub-47	3，4-diClPh	CH2	Single bond	Sub-22
						2-695	Sub-47	3，4-diClPh	CH2	Single bond	Sub-23
2-696	Sub-47	3，4-diClPh	CH2	Single bond	Sub-24
						2-697	Sub-47	3，4-diClPh	CH2	Single bond	Sub-25
2-698	Sub-47	3，4-diClPh	CH2	Single bond	Sub-26
						2-699	Sub-47	3，4-diClPh	CH2	Single bond	Sub-27
2-700	Sub-47	3，4-diClPh	CH2	Single bond	Sub-28
						2-701	Sub-47	3，4-diClPh	CH2	Single bond	Sub-29
2-702	Sub-47	3，4-diClPh	CH2	Single bond	Sub-30

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-703	Sub-47	3，4-diClPh	CH2	Single bond	Sub-31
2-704	Sub-47	3，4-diClPh	CH2	Single bond	Sub-32
						2-705	Sub-47	3，4-diClPh	CH2	Single bond	Sub-65
2-706	Sub-47	3，4-diClPh	CH2	Single bond	Sub-66
						2-707	Sub-47	3，4-diClPh	CH2	Single bond	Sub-67
2-708	Sub-47	3，4-diClPh	CH2	Single bond	Sub-68
						2-709	Sub-47	3，4-diClPh	CH2	Single bond	Sub-69
2-710	Sub-47	3，4-diClPh	CH2	Single bond	Sub-70
						2-711	Sub-47	3，4-diClPh	CH2	Single bond	Sub-71
2-712	Sub-47	3，4-diClPh	CH2	Single bond	Sub-72
						2-713	Sub-47	3，4-diClPh	CH2	Single bond	Sub-73
2-714	Sub-47	3，4-diClPh	CH2	Single bond	Sub-74
						2-715	Sub-47	3，4-diClPh	CH2	Single bond	Sub-75
2-716	Sub-47	3，4-diClPh	CH2	Single bond	Sub-76
						2-717	Sub-47	3，4-diClPh	CH2	Single bond	Sub-77
2-718	Sub-47	3，4-diClPh	CH2	Single bond	Sub-78
						2-719	Sub-47	3，4-diClPh	CH2	Single bond	Sub-79
2-720	Sub-47	3，4-diClPh	CH2	Single bond	Sub-80
						2-721	Sub-81	3，4-diClPh	CH2	Single bond	Sub-1
2-722	Sub-81	3，4-diClPh	CH2	Single bond	Sub-2
						2-723	Sub-81	3，4-diClPh	CH2	Single bond	Sub-3
2-724	Sub-81	3，4-diClPh	CH2	Single bond	Sub-4
						2-725	Sub-81	3，4-diClPh	CH2	Single bond	Sub-5
2-726	Sub-81	3，4-diClPh	CH2	Single bond	Sub-6
						2-727	Sub-81	3，4-diClPh	CH2	Single bond	Sub-7
2-728	Sub-81	3，4-diClPh	CH2	Single bond	Sub-8

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-729	Sub-81	3，4-diClPh	CH2	Single bond	Sub-9
2-730	Sub-81	3，4-diClPh	CH2	Single bond	Sub-10
						2-731	Sub-81	3，4-diClPh	CH2	Single bond	Sub-11
2-732	Sub-81	3，4-diClPh	CH2	Single bond	Sub-12
						2-733	Sub-81	3，4-diClPh	CH2	Single bond	Sub-13
2-734	Sub-81	3，4-diClPh	CH2	Single bond	Sub-14
						2-735	Sub-81	3，4-diClPh	CH2	Single bond	Sub-15
2-736	Sub-81	3，4-diClPh	CH2	Single bond	Sub-16
						2-737	Sub-81	3，4-diClPh	CH2	Single bond	Sub-17
2-738	Sub-81	3，4-diClPh	CH2	Single bond	Sub-18
						2-739	Sub-81	3，4-diClPh	CH2	Single bond	Sub-19
2-740	Sub-81	3，4-diClPh	CH2	Single bond	Sub-20
						2-741	Sub-81	3，4-diClPh	CH2	Single bond	Sub-21
2-742	Sub-81	3，4-diClPh	CH2	Single bond	Sub-22
						2-743	Sub-81	3，4-diClPh	CH2	Single bond	Sub-23
2-744	Sub-81	3，4-diClPh	CH2	Single bond	Sub-24
						2-745	Sub-81	3，4-diClPh	CH2	Single bond	Sub-25
2-746	Sub-81	3，4-diClPh	CH2	Single bond	Sub-26
						2-747	Sub-81	3，4-diClPh	CH2	Single bond	Sub-27
2-748	Sub-81	3，4-diClPh	CH2	Single bond	Sub-28
						2-749	Sub-81	3，4-diClPh	CH2	Single bond	Sub-29
2-750	Sub-81	3，4-diClPh	CH2	Single bond	Sub-30
						2-751	Sub-81	3，4-diClPh	CH2	Single bond	Sub-31
2-752	Sub-81	3，4-diClPh	CH2	Single bond	Sub-32
						2-753	Sub-81	3，4-diClPh	CH2	Single bond	Sub-65
2-754	Sub-81	3，4-diClPh	CH2	Single bond	Sub-66

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-755	Sub-81	3，4-diClPh	CH2	Single bond	Sub-67
2-756	Sub-81	3，4-diClPh	CH2	Single bond	Sub-68
						2-757	Sub-81	3，4-diClPh	CH2	Single bond	Sub-69
2-758	Sub-81	3，4-diClPh	CH2	Single bond	Sub-70
						2-759	Sub-81	3，4-diClPh	CH2	Single bond	Sub-71
2-760	Sub-81	3，4-diClPh	CH2	Single bond	Sub-72
						2-761	Sub-81	3，4-diClPh	CH2	Single bond	Sub-73
2-762	Sub-81	3，4-diClPh	CH2	Single bond	Sub-74
						2-763	Sub-81	3，4-diClPh	CH2	Single bond	Sub-75
2-764	Sub-81	3，4-diClPh	CH2	Single bond	Sub-76
						2-765	Sub-81	3，4-diClPh	CH2	Single bond	Sub-77
2-766	Sub-81	3，4-diClPh	CH2	Single bond	Sub-78
						2-767	Sub-81	3，4-diClPh	CH2	Single bond	Sub-79
2-768	Sub-81	3，4-diClPh	CH2	Single bond	Sub-80
						2-769	Sub-48	3，4-diClPh	CH2	Single bond	Sub-1
2-770	Sub-48	3，4-diClPh	CH2	Single bond	Sub-2
						2-771	Sub-48	3，4-diClPh	CH2	Single bond	Sub-3
2-772	Sub-48	3，4-diClPh	CH2	Single bond	Sub-4
						2-773	Sub-48	3，4-diClPh	CH2	Single bond	Sub-5
2-774	Sub-48	3，4-diClPh	CH2	Single bond	Sub-6
						2-775	Sub-48	3，4-diClPh	CH2	Single bond	Sub-7
2-776	Sub-48	3，4-diClPh	CH2	Single bond	Sub-8
						2-777	Sub-48	3，4-diClPh	CH2	Single bond	Sub-9
2-778	Sub-48	3，4-diClPh	CH2	Single bond	Sub-10
						2-779	Sub-48	3，4-diClPh	CH2	Single bond	Sub-11
2-780	Sub-48	3，4-diClPh	CH2	Single bond	Sub-12

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-781	Sub-48	3，4-diClPh	CH2	Single bond	Sub-13
2-782	Sub-48	3，4-diClPh	CH2	Single bond	Sub-14
						2-783	Sub-48	3，4-diClPh	CH2	Single bond	Sub-15
2-784	Sub-48	3，4-diClPh	CH2	Single bond	Sub-16
						2-785	Sub-48	3，4-diClPh	CH2	Single bond	Sub-17
2-786	Sub-48	3，4-diClPh	CH2	Single bond	Sub-18
						2-787	Sub-48	3，4-diClPh	CH2	Single bond	Sub-19
2-788	Sub-48	3，4-diClPh	CH2	Single bond	Sub-20
						2-789	Sub-48	3，4-diClPh	CH2	Single bond	Sub-21
2-790	Sub-48	3，4-diClPh	CH2	Single bond	Sub-22
						2-791	Sub-48	3，4-diClPh	CH2	Single bond	Sub-23
2-792	Sub-48	3，4-diClPh	CH2	Single bond	Sub-24
						2-793	Sub-48	3，4-diClPh	CH2	Single bond	Sub-25
2-794	Sub-48	3，4-diClPh	CH2	Single bond	Sub-26
						2-795	Sub-48	3，4-diClPh	CH2	Single bond	Sub-27
2-796	Sub-48	3，4-diClPh	CH2	Single bond	Sub-28
						2-797	Sub-48	3，4-diClPh	CH2	Single bond	Sub-29
2-798	Sub-48	3，4-diClPh	CH2	Single bond	Sub-30
						2-799	Sub-48	3，4-diClPh	CH2	Single bond	Sub-31
2-800	Sub-48	3，4-diClPh	CH2	Single bond	Sub-32
						2-801	Sub-48	3，4-diClPh	CH2	Single bond	Sub-65
2-802	Sub-48	3，4-diClPh	CH2	Single bond	Sub-66
						2-803	Sub-48	3，4-diClPh	CH2	Single bond	Sub-67
2-804	Sub-48	3，4-diClPh	CH2	Single bond	Sub-68
						2-805	Sub-48	3，4-diClPh	CH2	Single bond	Sub-69
2-806	Sub-48	3，4-diClPh	CH2	Single bond	Sub-70

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-807	Sub-48	3，4-diClPh	CH2	Single bond	Sub-71
2-808	Sub-48	3，4-diClPh	CH2	Single bond	Sub-72
						2-809	Sub-48	3，4-diClPh	CH2	Single bond	Sub-73
2-810	Sub-48	3，4-diClPh	CH2	Single bond	Sub-74
						2-811	Sub-48	3，4-diClPh	CH2	Single bond	Sub-75
2-812	Sub-48	3，4-diClPh	CH2	Single bond	Sub-76
						2-813	Sub-48	3，4-diClPh	CH2	Single bond	Sub-77
2-814	Sub-48	3，4-diClPh	CH2	Single bond	Sub-78
						2-815	Sub-48	3，4-diClPh	CH2	Single bond	Sub-79
2-816	Sub-48	3，4-diClPh	CH2	Single bond	Sub-80
						2-817	Sub-49	3，4-diClPh	CH2	Single bond	Sub-1
2-818	Sub-49	3，4-diClPh	CH2	Single bond	Sub-2
						2-819	Sub-49	3，4-diClPh	CH2	Single bond	Sub-3
2-820	Sub-49	3，4-diClPh	CH2	Single bond	Sub-4
						2-821	Sub-49	3，4-diClPh	CH2	Single bond	Sub-5
2-822	Sub-49	3，4-diClPh	CH2	Single bond	Sub-6
						2-823	Sub-49	3，4-diClPh	CH2	Single bond	Sub-7
2-824	Sub-49	3，4-diClPh	CH2	Single bond	Sub-8
						2-825	Sub-49	3，4-diClPh	CH2	Single bond	Sub-9
2-826	Sub-49	3，4-diClPh	CH2	Single bond	Sub-10
						2-827	Sub-49	3，4-diClPh	CH2	Single bond	Sub-11
2-828	Sub-49	3，4-diClPh	CH2	Single bond	Sub-12
						2-829	Sub-49	3，4-diClPh	CH2	Single bond	Sub-13
2-830	Sub-49	3，4-diClPh	CH2	Single bond	Sub-14
						2-831	Sub-49	3，4-diClPh	CH2	Single bond	Sub-15
2-832	Sub-49	3，4-diClPh	CH2	Single bond	Sub-16

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-833	Sub-49	3，4-diClPh	CH2	Single bond	Sub-17
2-834	Sub-49	3，4-diClPh	CH2	Single bond	Sub-18
						2-835	Sub-49	3，4-diClPh	CH2	Single bond	Sub-19
2-836	Sub-49	3，4-diClPh	CH2	Single bond	Sub-20
						2-837	Sub-49	3，4-diClPh	CH2	Single bond	Sub-21
2-838	Sub-49	3，4-diClPh	CH2	Single bond	Sub-22
						2-839	Sub-49	3，4-diClPh	CH2	Single bond	Sub-23
2-840	Sub-49	3，4-diClPh	CH2	Single bond	Sub-24
						2-841	Sub-49	3，4-diClPh	CH2	Single bond	Sub-25
2-842	Sub-49	3，4-diClPh	CH2	Single bond	Sub-26
						2-843	Sub-49	3，4-diClPh	CH2	Single bond	Sub-27
2-844	Sub-49	3，4-diClPh	CH2	Single bond	Sub-28
						2-845	Sub-49	3，4-diClPh	CH2	Single bond	Sub-29
2-846	Sub-49	3，4-diClPh	CH2	Single bond	Sub-30
						2-847	Sub-49	3，4-diClPh	CH2	Single bond	Sub-31
2-848	Sub-49	3，4-diClPh	CH2	Single bond	Sub-32
						2-849	Sub-49	3，4-diClPh	CH2	Single bond	Sub-65
2-850	Sub-49	3，4-diClPh	CH2	Single bond	Sub-66
						2-851	Sub-49	3，4-diClPh	CH2	Single bond	Sub-67
2-852	Sub-49	3，4-diClPh	CH2	Single bond	Sub-68
						2-853	Sub-49	3，4-diClPh	CH2	Single bond	Sub-69
2-854	Sub-49	3，4-diClPh	CH2	Single bond	Sub-70
						2-855	Sub-49	3，4-diClPh	CH2	Single bond	Sub-71
2-856	Sub-49	3，4-diClPh	CH2	Single bond	Sub-72
						2-857	Sub-49	3，4-diClPh	CH2	Single bond	Sub-73
2-858	Sub-49	3，4-diClPh	CH2	Single bond	Sub-74

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-859	Sub-49	3，4-diClPh	CH2	Single bond	Sub-75
2-860	Sub-49	3，4-diClPh	CH2	Single bond	Sub-76
						2-861	Sub-49	3，4-diClPh	CH2	Single bond	Sub-77
2-862	Sub-49	3，4-diClPh	CH2	Single bond	Sub-78
						2-863	Sub-49	3，4-diClPh	CH2	Single bond	Sub-79
2-864	Sub-49	3，4-diClPh	CH2	Single bond	Sub-80
						2-865	Sub-50	3，4-diClPh	CH2	Single bond	Sub-1
2-866	Sub-50	3，4-diClPh	CH2	Single bond	Sub-2
						2-867	Sub-50	3，4-diClPh	CH2	Single bond	Sub-3
2-868	Sub-50	3，4-diClPh	CH2	Single bond	Sub-4
						2-869	Sub-50	3，4-diClPh	CH2	Single bond	Sub-5
2-870	Sub-50	3，4-diClPh	CH2	Single bond	Sub-6
						2-871	Sub-50	3，4-diClPh	CH2	Single bond	Sub-7
2-872	Sub-50	3，4-diClPh	CH2	Single bond	Sub-8
						2-873	Sub-50	3，4-diClPh	CH2	Single bond	Sub-9
2-874	Sub-50	3，4-diClPh	CH2	Single bond	Sub-10
						2-875	Sub-50	3，4-diClPh	CH2	Single bond	Sub-11
2-876	Sub-50	3，4-diClPh	CH2	Single bond	Sub-12
						2-877	Sub-50	3，4-diClPh	CH2	Single bond	Sub-13
2-878	Sub-50	3，4-diClPh	CH2	Single bond	Sub-14
						2-879	Sub-50	3，4-diClPh	CH2	Single bond	Sub-15
2-880	Sub-50	3，4-diClPh	CH2	Single bond	Sub-16
						2-881	Sub-50	3，4-diClPh	CH2	Single bond	Sub-17
2-882	Sub-50	3，4-diClPh	CH2	Single bond	Sub-18
						2-883	Sub-50	3，4-diClPh	CH2	Single bond	Sub-19
2-884	Sub-50	3，4-diClPh	CH2	Single bond	Sub-20

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-885	Sub-50	3，4-diClPh	CH2	Single bond	Sub-21
2-886	Sub-50	3，4-diClPh	CH2	Single bond	Sub-22
						2-887	Sub-50	3，4-diClPh	CH2	Single bond	Sub-23
2-888	Sub-50	3，4-diClPh	CH2	Single bond	Sub-24
						2-889	Sub-50	3，4-diClPh	CH2	Single bond	Sub-25
2-890	Sub-50	3，4-diClPh	CH2	Single bond	Sub-26
						2-891	Sub-50	3，4-diClPh	CH2	Single bond	Sub-27
2-892	Sub-50	3，4-diClPh	CH2	Single bond	Sub-28
						2-893	Sub-50	3，4-diClPh	CH2	Single bond	Sub-29
2-894	Sub-50	3，4-diClPh	CH2	Single bond	Sub-30
						2-895	Sub-50	3，4-diClPh	CH2	Single bond	Sub-31
2-896	Sub-50	3，4-diClPh	CH2	Single bond	Sub-32
						2-897	Sub-50	3，4-diClPh	CH2	Single bond	Sub-65
2-898	Sub-50	3，4-diClPh	CH2	Single bond	Sub-66
						2-899	Sub-50	3，4-diClPh	CH2	Single bond	Sub-67
2-900	Sub-50	3，4-diClPh	CH2	Single bond	Sub-68
						2-901	Sub-50	3，4-diClPh	CH2	Single bond	Sub-69
2-902	Sub-50	3，4-diClPh	CH2	Single bond	Sub-70
						2-903	Sub-50	3，4-diClPh	CH2	Single bond	Sub-71
2-904	Sub-50	3，4-diClPh	CH2	Single bond	Sub-72
						2-905	Sub-50	3，4-diClPh	CH2	Single bond	Sub-73
2-906	Sub-50	3，4-diClPh	CH2	Single bond	Sub-74
						2-907	Sub-50	3，4-diClPh	CH2	Single bond	Sub-75
2-908	Sub-50	3，4-diClPh	CH2	Single bond	Sub-76
						2-909	Sub-50	3，4-diClPh	CH2	Single bond	Sub-77
2-910	Sub-50	3，4-diClPh	CH2	Single bond	Sub-78

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-911	Sub-50	3，4-diClPh	CH2	Single bond	Sub-79
2-912	Sub-50	3，4-diClPh	CH2	Single bond	Sub-80
						2-913	Sub-51	3，4-diClPh	CH2	Single bond	Sub-1
2-914	Sub-51	3，4-diClPh	CH2	Single bond	Sub-2
						2-915	Sub-51	3，4-diClPh	CH2	Single bond	Sub-3
2-916	Sub-51	3，4-diClPh	CH2	Single bond	Sub-4
						2-917	Sub-51	3，4-diClPh	CH2	Single bond	Sub-5
2-918	Sub-51	3，4-diClPh	CH2	Single bond	Sub-6
						2-919	Sub-51	3，4-diClPh	CH2	Single bond	Sub-7
2-920	Sub-51	3，4-diClPh	CH2	Single bond	Sub-8
						2-921	Sub-51	3，4-diClPh	CH2	Single bond	Sub-9
2-922	Sub-51	3，4-diClPh	CH2	Single bond	Sub-10
						2-923	Sub-51	3，4-diClPh	CH2	Single bond	Sub-11
2-924	Sub-51	3，4-diClPh	CH2	Single bond	Sub-12
						2-925	Sub-51	3，4-diClPh	CH2	Single bond	Sub-13
2-926	Sub-51	3，4-diClPh	CH2	Single bond	Sub-14
						2-927	Sub-51	3，4-diClPh	CH2	Single bond	Sub-15
2-928	Sub-51	3，4-diClPh	CH2	Single bond	Sub-16
						2-929	Sub-51	3，4-diClPh	CH2	Single bond	Sub-17
2-930	Sub-51	3，4-diClPh	CH2	Single bond	Sub-18
						2-931	Sub-51	3，4-diClPh	CH2	Single bond	Sub-19
2-932	Sub-51	3，4-diClPh	CH2	Single bond	Sub-20
						2-933	Sub-51	3，4-diClPh	CH2	Single bond	Sub-21
2-934	Sub-51	3，4-diClPh	CH2	Single bond	Sub-22
						2-935	Sub-51	3，4-diClPh	CH2	Single bond	Sub-23
2-936	Sub-51	3，4-diClPh	CH2	Single bond	Sub-24

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-937	Sub-51	3，4-diClPh	CH2	Single bond	Sub-25
2-938	Sub-51	3，4-diClPh	CH2	Single bond	Sub-26
						2-939	Sub-51	3，4-diClPh	CH2	Single bond	Sub-27
2-940	Sub-51	3，4-diClPh	CH2	Single bond	Sub-28
						2-941	Sub-51	3，4-diClPh	CH2	Single bond	Sub-29
2-942	Sub-51	3，4-diClPh	CH2	Single bond	Sub-30
						2-943	Sub-51	3，4-diClPh	CH2	Single bond	Sub-31
2-944	Sub-51	3，4-diClPh	CH2	Single bond	Sub-32
						2-945	Sub-51	3，4-diClPh	CH2	Single bond	Sub-65
2-946	Sub-51	3，4-diClPh	CH2	Single bond	Sub-66
						2-947	Sub-51	3，4-diClPh	CH2	Single bond	Sub-67
2-948	Sub-51	3，4-diClPh	CH2	Single bond	Sub-68
						2-949	Sub-51	3，4-diClPh	CH2	Single bond	Sub-69
2-950	Sub-51	3，4-diClPh	CH2	Single bond	Sub-70
						2-951	Sub-51	3，4-diClPh	CH2	Single bond	Sub-71
2-952	Sub-51	3，4-diClPh	CH2	Single bond	Sub-72
						2-953	Sub-51	3，4-diClPh	CH2	Single bond	Sub-73
2-954	Sub-51	3，4-diClPh	CH2	Single bond	Sub-74
						2-955	Sub-51	3，4-diClPh	CH2	Single bond	Sub-75
2-956	Sub-51	3，4-diClPh	CH2	Single bond	Sub-76
						2-957	Sub-51	3，4-diClPh	CH2	Single bond	Sub-77
2-958	Sub-51	3，4-diClPh	CH2	Single bond	Sub-78
						2-959	Sub-51	3，4-diClPh	CH2	Single bond	Sub-79
2-960	Sub-51	3，4-diClPh	CH2	Single bond	Sub-80
						2-961	Sub-52	3，4-diClPh	CH2	Single bond	Sub-1
2-962	Sub-52	3，4-diClPh	CH2	Single bond	Sub-2

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-963	Sub-52	3，4-diClPh	CH2	Single bond	Sub-3
2-964	Sub-52	3，4-diClPh	CH2	Single bond	Sub-4
						2-965	Sub-52	3，4-diClPh	CH2	Single bond	Sub-5
2-966	Sub-52	3，4-diClPh	CH2	Single bond	Sub-6
						2-967	Sub-52	3，4-diClPh	CH2	Single bond	Sub-7
2-968	Sub-52	3，4-diClPh	CH2	Single bond	Sub-8
						2-969	Sub-52	3，4-diClPh	CH2	Single bond	Sub-9
2-970	Sub-52	3，4-diClPh	CH2	Single bond	Sub-10
						2-971	Sub-52	3，4-diClPh	CH2	Single bond	Sub-11
2-972	Sub-52	3，4-diClPh	CH2	Single bond	Sub-12
						2-973	Sub-52	3，4-diClPh	CH2	Single bond	Sub-13
2-974	Sub-52	3，4-diClPh	CH2	Single bond	Sub-14
						2-975	Sub-52	3，4-diClPh	CH2	Single bond	Sub-15
2-976	Sub-52	3，4-diClPh	CH2	Single bond	Sub-16
						2-977	Sub-52	3，4-diClPh	CH2	Single bond	Sub-17
2-978	Sub-52	3，4-diClPh	CH2	Single bond	Sub-18
						2-979	Sub-52	3，4-diClPh	CH2	Single bond	Sub-19
2-980	Sub-52	3，4-diClPh	CH2	Single bond	Sub-20
						2-981	Sub-52	3，4-diClPh	CH2	Single bond	Sub-21
2-982	Sub-52	3，4-diClPh	CH2	Single bond	Sub-22
						2-983	Sub-52	3，4-diClPh	CH2	Single bond	Sub-23
2-984	Sub-52	3，4-diClPh	CH2	Single bond	Sub-24
						2-985	Sub-52	3，4-diClPh	CH2	Single bond	Sub-25
2-986	Sub-52	3，4-diClPh	CH2	Single bond	Sub-26
						2-987	Sub-52	3，4-diClPh	CH2	Single bond	Sub-27
2-988	Sub-52	3，4-diClPh	CH2	Single bond	Sub-28

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-989	Sub-52	3，4-diClPh	CH2	Single bond	Sub-29
2-990	Sub-52	3，4-diClPh	CH2	Single bond	Sub-30
						2-991	Sub-52	3，4-diClPh	CH2	Single bond	Sub-31
2-992	Sub-52	3，4-diClPh	CH2	Single bond	Sub-32
						2-993	Sub-52	3，4-diClPh	CH2	Single bond	Sub-65
2-994	Sub-52	3，4-diClPh	CH2	Single bond	Sub-66
						2-995	Sub-52	3，4-diClPh	CH2	Single bond	Sub-67
2-996	Sub-52	3，4-diClPh	CH2	Single bond	Sub-68
						2-997	Sub-52	3，4-diClPh	CH2	Single bond	Sub-69
2-998	Sub-52	3，4-diClPh	CH2	Single bond	Sub-70
						2-999	Sub-52	3，4-diClPh	CH2	Single bond	Sub-71
2-1000	Sub-52	3，4-diClPh	CH2	Single bond	Sub-72
						2-1001	Sub-52	3，4-diClPh	CH2	Single bond	Sub-73
2-1002	Sub-52	3，4-diClPh	CH2	Single bond	Sub-74
						2-1003	Sub-52	3，4-diClPh	CH2	Single bond	Sub-75
2-1004	Sub-52	3，4-diClPh	CH2	Single bond	Sub-76
						2-1005	Sub-52	3，4-diClPh	CH2	Single bond	Sub-77
2-1006	Sub-52	3，4-diClPh	CH2	Single bond	Sub-78
						2-1007	Sub-52	3，4-diClPh	CH2	Single bond	Sub-79
2-1008	Sub-52	3，4-diClPh	CH2	Single bond	Sub-80
						2-1009	Sub-53	3，4-diClPh	CH2	Single bond	Sub-1
2-1010	Sub-53	3，4-diClPh	CH2	Single bond	Sub-2
						2-1011	Sub-53	3，4-diClPh	CH2	Single bond	Sub-3
2-1012	Sub-53	3，4-diClPh	CH2	Single bond	Sub-4
						2-1013	Sub-53	3，4-diClPh	CH2	Single bond	Sub-5
2-1014	Sub-53	3，4-diClPh	CH2	Single bond	Sub-6

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1015	Sub-53	3，4-diClPh	CH2	Single bond	Sub-7
2-1016	Sub-53	3，4-diClPh	CH2	Single bond	Sub-8
						2-1017	Sub-53	3，4-diClPh	CH2	Single bond	Sub-9
2-1018	Sub-53	3，4-diClPh	CH2	Single bond	Sub-10
						2-1019	Sub-53	3，4-diClPh	CH2	Single bond	Sub-11
2-1020	Sub-53	3，4-diClPh	CH2	Single bond	Sub-12
						2-1021	Sub-53	3，4-diClPh	CH2	Single bond	Sub-13
2-1022	Sub-53	3，4-diClPh	CH2	Single bond	Sub-14
						2-1023	Sub-53	3，4-diClPh	CH2	Single bond	Sub-15
2-1024	Sub-53	3，4-diClPh	CH2	Single bond	Sub-16
						2-1025	Sub-53	3，4-diClPh	CH2	Single bond	Sub-17
2-1026	Sub-53	3，4-diClPh	CH2	Single bond	Sub-18
						2-1027	Sub-53	3，4-diClPh	CH2	Single bond	Sub-19
2-1028	Sub-53	3，4-diClPh	CH2	Single bond	Sub-20
						2-1029	Sub-53	3，4-diClPh	CH2	Single bond	Sub-21
2-1030	Sub-53	3，4-diClPh	CH2	Single bond	Sub-22
						2-1031	Sub-53	3，4-diClPh	CH2	Single bond	Sub-23
2-1032	Sub-53	3，4-diClPh	CH2	Single bond	Sub-24
						2-1033	Sub-53	3，4-diClPh	CH2	Single bond	Sub-25
2-1034	Sub-53	3，4-diClPh	CH2	Single bond	Sub-26
						2-1035	Sub-53	3，4-diClPh	CH2	Single bond	Sub-27
2-1036	Sub-53	3，4-diClPh	CH2	Single bond	Sub-28
						2-1037	Sub-53	3，4-diClPh	CH2	Single bond	Sub-29
2-1038	Sub-53	3，4-diClPh	CH2	Single bond	Sub-30
						2-1039	Sub-53	3，4-diClPh	CH2	Single bond	Sub-31
2-1040	Sub-53	3，4-diClPh	CH2	Single bond	Sub-32

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1041	Sub-53	3，4-diClPh	CH2	Single bond	Sub-65
2-1042	Sub-53	3，4-diClPh	CH2	Single bond	Sub-66
						2-1043	Sub-53	3，4-diClPh	CH2	Single bond	Sub-67
2-1044	Sub-53	3，4-diClPh	CH2	Single bond	Sub-68
						2-1045	Sub-53	3，4-diClPh	CH2	Single bond	Sub-69
2-1046	Sub-53	3，4-diClPh	CH2	SheetKey with a key body	Sub-70
						2-1047	Sub-53	3，4-diClPh	CH2	Single bond	Sub-71
2-1048	Sub-53	3，4-diClPh	CH2	Single bond	Sub-72
						2-1049	Sub-53	3，4-diClPh	CH2	Single bond	Sub-73
2-1050	Sub-53	3，4-diClPh	CH2	Single bond	Sub-74
						2-1051	Sub-53	3，4-diClPh	CH2	Single bond	Sub-75
2-1052	Sub-53	3，4-diClPh	CH2	Single bond	Sub-76
						2-1053	Sub-53	3，4-diClPh	CH2	Single bond	Sub-77
2-1054	Sub-53	3，4-diClPh	CH2	Single bond	Sub-78
						2-1055	Sub-53	3，4-diClPh	CH2	Single bond	Sub-79
2-1056	Sub-53	3，4-diClPh	CH2	Single bond	Sub-80
						2-1057	Sub-54	3，4-diClPh	CH2	Single bond	Sub-1
2-1058	Sub-54	3，4-diClPh	CH2	Single bond	Sub-2
						2-1059	Sub-54	3，4-diClPh	CH2	Single bond	Sub-3
2-1060	Sub-54	3，4-diClPh	CH2	Single bond	Sub-4
						2-1061	Sub-54	3，4-diClPh	CH2	Single bond	Sub-5
2-1062	Sub-54	3，4-diClPh	CH2	Single bond	Sub-6
						2-1063	Sub-54	3，4-diClPh	CH2	Single bond	Sub-7
2-1064	Sub-54	3，4-diClPh	CH2	Single bond	Sub-8
						2-1065	Sub-54	3，4-diClPh	CH2	Single bond	Sub-9
2-1066	Sub-54	3，4-diClPh	CH2	Single bond	Sub-10

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1067	Sub-54	3，4-diClPh	CH2	Single bond	Sub-11
2-1068	Sub-54	3，4-diClPh	CH2	Single bond	Sub-12
						2-1069	Sub-54	3，4-diClPh	CH2	Single bond	Sub-13
2-1070	Sub-54	3，4-diClPh	CH2	Single bond	Sub-14
						2-1071	Sub-54	3，4-diClPh	CH2	Single bond	Sub-15
2-1072	Sub-54	3，4-diClPh	CH2	Single bond	Sub-16
						2-1073	Sub-54	3，4-diClPh	CH2	Single bond	Sub-17
2-1074	Sub-54	3，4-diClPh	CH2	Single bond	Sub-18
						2-1075	Sub-54	3，4-diClPh	CH2	Single bond	Sub-19
2-1076	Sub-54	3，4-diClPh	CH2	Single bond	Sub-20
						2-1077	Sub-54	3，4-diClPh	CH2	Single bond	Sub-21
2-1078	Sub-54	3，4-diClPh	CH2	Single bond	Sub-22
						2-1079	Sub-54	3，4-diClPh	CH2	Single bond	Sub-23
2-1080	Sub-54	3，4-diClPh	CH2	Single bond	Sub-24
						2-1081	Sub-54	3，4-diClPh	CH2	Single bond	Sub-25
2-1082	Sub-54	3，4-diClPh	CH2	Single bond	Sub-26
						2-1083	Sub-54	3，4-diClPh	CH2	Single bond	Sub-27
2-1084	Sub-54	3，4-diClPh	CH2	Single bond	Sub-28
						2-1085	Sub-54	3，4-diClPh	CH2	Single bond	Sub-29
2-1086	Sub-54	3，4-diClPh	CH2	Single bond	Sub-30
						2-1087	Sub-54	3，4-diClPh	CH2	Single bond	Sub-31
2-1088	Sub-54	3，4-diClPh	CH2	Single bond	Sub-32
						2-1089	Sub-54	3，4-diClPh	CH2	Single bond	Sub-65
2-1090	Sub-54	3，4-diClPh	CH2	Single bond	Sub-66
						2-1091	Sub-54	3，4-diClPh	CH2	Single bond	Sub-67
2-1092	Sub-54	3，4-diClPh	CH2	Single bond	Sub-68

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1093	Sub-54	3，4-diClPh	CH2	Single bond	Sub-69
2-1094	Sub-54	3，4-diClPh	CH2	Single bond	Sub-70
						2-1095	Sub-54	3，4-diClPh	CH2	Single bond	Sub-71
2-1096	Sub-54	3，4-diClPh	CH2	Single bond	Sub-72
						2-1097	Sub-54	3，4-diClPh	CH2	Single bond	Sub-73
2-1098	Sub-54	3，4-diClPh	CH2	Single bond	Sub-74
						2-1099	Sub-54	3，4-diClPh	CH2	Single bond	Sub-75
2-1100	Sub-54	3，4-diClPh	CH2	Single bond	Sub-76
						2-1101	Sub-54	3，4-diClPh	CH2	Single bond	Sub-77
2-1102	Sub-54	3，4-diClPh	CH2	Single bond	Sub-78
						2-1103	Sub-54	3，4-diClPh	CH2	Single bond	Sub-79
2-1104	Sub-54	3，4-diClPh	CH2	Single bond	Sub-80
						2-1105	Sub-55	3，4-diClPh	CH2	Single bond	Sub-1
2-1106	Sub-55	3，4-diClPh	CH2	Single bond	Sub-2
						2-1107	Sub-55	3，4-diClPh	CH2	Single bond	Sub-3
2-1108	Sub-55	3，4-diClPh	CH2	Single bond	Sub-4
						2-1109	Sub-55	3，4-diClPh	CH2	Single bond	Sub-5
2-1110	Sub-55	3，4-diClPh	CH2	Single bond	Sub-6
						2-1111	Sub-55	3，4-diClPh	CH2	Single bond	Sub-7
2-1112	Sub-55	3，4-diClPh	CH2	Single bond	Sub-8
						2-1113	Sub-55	3，4-diClPh	CH2	Single bond	Sub-9
2-1114	Sub-55	3，4-diClPh	CH2	Single bond	Sub-10
						2-1115	Sub-55	3，4-diClPh	CH2	Single bond	Sub-11
2-1116	Sub-55	3，4-diClPh	CH2	Single bond	Sub-12
						2-1117	Sub-55	3，4-diClPh	CH2	Single bond	Sub-13
2-1118	Sub-55	3，4-diClPh	CH2	Single bond	Sub-14

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1119	Sub-55	3，4-diClPh	CH2	Single bond	Sub-15
2-1120	Sub-55	3，4-diClPh	CH2	Single bond	Sub-16
						2-1121	Sub-55	3，4-diClPh	CH2	Single bond	Sub-17
2-1122	Sub-55	3，4-diClPh	CH2	Single bond	Sub-18
						2-1123	Sub-55	3，4-diClPh	CH2	Single bond	Sub-19
2-1124	Sub-55	3，4-diClPh	CH2	Single bond	Sub-20
						2-1125	Sub-55	3，4-diClPh	CH2	Single bond	Sub-21
2-1126	Sub-55	3，4-diClPh	CH2	Single bond	Sub-22
						2-1127	Sub-55	3，4-diClPh	CH2	Single bond	Sub-23
2-1128	Sub-55	3，4-diClPh	CH2	Single bond	Sub-24
						2-1129	Sub-55	3，4-diClPh	CH2	Single bond	Sub-25
2-1130	Sub-55	3，4-diClPh	CH2	Single bond	Sub-26
						2-1131	Sub-55	3，4-diClPh	CH2	Single bond	Sub-27
2-1132	Sub-55	3，4-diClPh	CH2	Single bond	Sub-28
						2-1133	Sub-55	3，4-diClPh	CH2	Single bond	Sub-29
2-1134	Sub-55	3，4-diClPh	CH2	Single bond	Sub-30
						2-1135	Sub-55	3，4-diClPh	CH2	Single bond	Sub-31
2-1136	Sub-55	3，4-diClPh	CH2	Single bond	Sub-32
						2-1137	Sub-55	3，4-diClPh	CH2	Single bond	Sub-65
2-1138	Sub-55	3，4-diClPh	CH2	Single bond	Sub-66
						2-1139	Sub-55	3，4-diClPh	CH2	Single bond	Sub-67
2-1140	Sub-55	3，4-diClPh	CH2	Single bond	Sub-68
						2-1141	Sub-55	3，4-diClPh	CH2	Single bond	Sub-69
2-1142	Sub-55	3，4-diClPh	CH2	Single bond	Sub-70
						2-1143	Sub-55	3，4-diClPh	CH2	Single bond	Sub-71
2-1144	Sub-55	3，4-diClPh	CH2	Single bond	Sub-72

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1145	Sub-55	3，4-diClPh	CH2	Single bond	Sub-73
2-1146	Sub-55	3，4-diClPh	CH2	Single bond	Sub-74
						2-1147	Sub-55	3，4-diClPh	CH2	Single bond	Sub-75
2-1148	Sub-55	3，4-diClPh	CH2	Single bond	Sub-76
						2-1149	Sub-55	3，4-diClPh	CH2	Single bond	Sub-77
2-1150	Sub-55	3，4-diClPh	CH2	Single bond	Sub-78
						2-1151	Sub-55	3，4-diClPh	CH2	Single bond	Sub-79
2-1152	Sub-55	3，4-diClPh	CH2	Single bond	Sub-80
						2-1153	Sub-56	3，4-diClPh	CH2	Single bond	Sub-1
2-1154	Sub-56	3，4-diClPh	CH2	Single bond	Sub-2
						2-1155	Sub-56	3，4-diClPh	CH2	Single bond	Sub-3
2-1156	Sub-56	3，4-diClPh	CH2	Single bond	Sub-4
						2-1157	Sub-56	3，4-diClPh	CH2	Single bond	Sub-5
2-1158	Sub-56	3，4-diClPh	CH2	Single bond	Sub-6
						2-1159	Sub-56	3，4-diClPh	CH2	Single bond	Sub-7
2-1160	Sub-56	3，4-diClPh	CH2	Single bond	Sub-8
						2-1161	Sub-56	3，4-diClPh	CH2	Single bond	Sub-9
2-1162	Sub-56	3，4-diClPh	CH2	Single bond	Sub-10
						2-1163	Sub-56	3，4-diClPh	CH2	Single bond	Sub-11
2-1164	Sub-56	3，4-diClPh	CH2	Single bond	Sub-12
						2-1165	Sub-56	3，4-diClPh	CH2	Single bond	Sub-13
2-1166	Sub-56	3，4-diClPh	CH2	Single bond	Sub-14
						2-1167	Sub-56	3，4-diClPh	CH2	Single bond	Sub-15
2-1168	Sub-56	3，4-diClPh	CH2	Single bond	Sub-16
						2-1169	Sub-56	3，4-diClPh	CH2	Single bond	Sub-17
2-1170	Sub-56	3，4-diClPh	CH2	Single bond	Sub-18

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1171	Sub-56	3，4-diClPh	CH2	Single bond	Sub-19
2-1172	Sub-56	3，4-diClPh	CH2	Single bond	Sub-20
						2-1173	Sub-56	3，4-diClPh	CH2	Single bond	Sub-21
2-1174	Sub-56	3，4-diClPh	CH2	Single bond	Sub-22
						2-1175	Sub-56	3，4-diClPh	CH2	Single bond	Sub-23
2-1176	Sub-56	3，4-diClPh	CH2	Single bond	Sub-24
						2-1177	Sub-56	3，4-diClPh	CH2	Single bond	Sub-25
2-1178	Sub-56	3，4-diClPh	CH2	Single bond	Sub-26
						2-1179	Sub-56	3，4-diClPh	CH2	Single bond	Sub-27
2-1180	Sub-56	3，4-diClPh	CH2	Single bond	Sub-28
						2-1181	Sub-56	3，4-diClPh	CH2	Single bond	Sub-29
2-1182	Sub-56	3，4-diClPh	CH2	Single bond	Sub-30
						2-1183	Sub-56	3，4-diClPh	CH2	Single bond	Sub-31
2-1184	Sub-56	3，4-diClPh	CH2	Single bond	Sub-32
						2-1185	Sub-56	3，4-diClPh	CH2	Single bond	Sub-65
2-1186	Sub-56	3，4-diClPh	CH2	Single bond	Sub-66
						2-1187	Sub-56	3，4-diClPh	CH2	Single bond	Sub-67
2-1188	Sub-56	3，4-diClPh	CH2	Single bond	Sub-68
						2-1189	Sub-56	3，4-diClPh	CH2	Single bond	Sub-69
2-1190	Sub-56	3，4-diClPh	CH2	Single bond	Sub-70
						2-1191	Sub-56	3，4-diClPh	CH2	Single bond	Sub-71
2-1192	Sub-56	3，4-diClPh	CH2	Single bond	Sub-72
						2-1193	Sub-56	3，4-diClPh	CH2	Single bond	Sub-73
2-1194	Sub-56	3，4-diClPh	CH2	Single bond	Sub-74
						2-1195	Sub-56	3，4-diClPh	CH2	Single bond	Sub-75
2-1196	Sub-56	3，4-diClPh	CH2	Single bond	Sub-76

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1197	Sub-56	3，4-diClPh	CH2	Single bond	Sub-77
2-1198	Sub-56	3，4-diClPh	CH2	Single bond	Sub-78
						2-1199	Sub-56	3，4-diClPh	CH2	Single bond	Sub-79
2-1200	Sub-56	3，4-diClPh	CH2	Single bond	Sub-80
						2-1201	Sub-57	3，4-diClPh	CH2	Single bond	Sub-1
2-1202	Sub-57	3，4-diClPh	CH2	Single bond	Sub-2
						2-1203	Sub-57	3，4-diClPh	CH2	Single bond	Sub-3
2-1204	Sub-57	3，4-diClPh	CH2	Single bond	Sub-4
						2-1205	Sub-57	3，4-diClPh	CH2	Single bond	Sub-5
2-1206	Sub-57	3，4-diClPh	CH2	Single bond	Sub-6
						2-1207	Sub-57	3，4-diClPh	CH2	Single bond	Sub-7
2-1208	Sub-57	3，4-diClPh	CH2	Single bond	Sub-8
						2-1209	Sub-57	3，4-diClPh	CH2	Single bond	Sub-9
2-1210	Sub-57	3，4-diClPh	CH2	Single bond	Sub-10
						2-1211	Sub-57	3，4-diClPh	CH2	Single bond	Sub-11
2-1212	Sub-57	3，4-diClPh	CH2	Single bond	Sub-12
						2-1213	Sub-57	3，4-diClPh	CH2	Single bond	Sub-13
2-1214	Sub-57	3，4-diClPh	CH2	Single bond	Sub-14
						2-1215	Sub-57	3，4-diClPh	CH2	Single bond	Sub-15
2-1216	Sub-57	3，4-diClPh	CH2	Single bond	Sub-16
						2-1217	Sub-57	3，4-diClPh	CH2	Single bond	Sub-17
2-1218	Sub-57	3，4-diClPh	CH2	Single bond	Sub-18
						2-1219	Sub-57	3，4-diClPh	CH2	Single bond	Sub-19
2-1220	Sub-57	3，4-diClPh	CH2	Single bond	Sub-20
						2-1221	Sub-57	3，4-diClPh	CH2	Single bond	Sub-21
2-1222	Sub-57	3，4-diClPh	CH2	Single bond	Sub-22

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1223	Sub-57	3，4-diClPh	CH2	Single bond	Sub-23
2-1224	Sub-57	3，4-diClPh	CH2	Single bond	Sub-24
						2-1225	Sub-57	3，4-diClPh	CH2	Single bond	Sub-25
2-1226	Sub-57	3，4-diClPh	CH2	Single bond	Sub-26
						2-1227	Sub-57	3，4-diClPh	CH2	Single bond	Sub-27
2-1228	Sub-57	3，4-diClPh	CH2	Single bond	Sub-28
						2-1229	Sub-57	3，4-diClPh	CH2	Single bond	Sub-29
2-1230	Sub-57	3，4-diClPh	CH2	Single bond	Sub-30
						2-1231	Sub-57	3，4-diClPh	CH2	Single bond	Sub-31
2-1232	Sub-57	3，4-diClPh	CH2	Single bond	Sub-32
						2-1233	Sub-57	3，4-diClPh	CH2	Single bond	Sub-65
2-1234	Sub-57	3，4-diClPh	CH2	Single bond	Sub-66
						2-1235	Sub-57	3，4-diClPh	CH2	Single bond	Sub-67
2-1236	Sub-57	3，4-diClPh	CH2	Single bond	Sub-68
						2-1237	Sub-57	3，4-diClPh	CH2	Single bond	Sub-69
2-1238	Sub-57	3，4-diClPh	CH2	Single bond	Sub-70
						2-1239	Sub-57	3，4-diClPh	CH2	Single bond	Sub-71
2-1240	Sub-57	3，4-diClPh	CH2	Single bond	Sub-72
						2-1241	Sub-57	3，4-diClPh	CH2	Single bond	Sub-73
2-1242	Sub-57	3，4-diClPh	CH2	Single bond	Sub-74
						2-1243	Sub-57	3，4-diClPh	CH2	Single bond	Sub-75
2-1244	Sub-57	3，4-diClPh	CH2	Single bond	Sub-76
						2-1245	Sub-57	3，4-diClPh	CH2	Single bond	Sub-77
2-1246	Sub-57	3，4-diClPh	CH2	Single bond	Sub-78
						2-1247	Sub-57	3，4-diClPh	CH2	Single bond	Sub-79
2-1248	Sub-57	3，4-diClPh	CH2	Single bond	Sub-80

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1249	Sub-58	3，4-diClPh	CH2	Single bond	Sub-1
2-1250	Sub-58	3，4-diClPh	CH2	Single bond	Sub-2
						2-1251	Sub-58	3，4-diClPh	CH2	Single bond	Sub-3
2-1252	Sub-58	3，4-diClPh	CH2	Single bond	Sub-4
						2-1253	Sub-58	3，4-diClPh	CH2	Single bond	Sub-5
2-1254	Sub-58	3，4-diClPh	CH2	Single bond	Sub-6
						2-1255	Sub-58	3，4-diClPh	CH2	Single bond	Sub-7
2-1256	Sub-58	3，4-diClPh	CH2	Single bond	Sub-8
						2-1257	Sub-58	3，4-diClPh	CH2	Single bond	Sub-9
2-1258	Sub-58	3，4-diClPh	CH2	Single bond	Sub-10
						2-1259	Sub-58	3，4-diClPh	CH2	Single bond	Sub-11
2-1260	Sub-58	3，4-diClPh	CH2	Single bond	Sub-12
						2-1261	Sub-58	3，4-diClPh	CH2	Single bond	Sub-13
2-1262	Sub-58	3，4-diClPh	CH2	Single bond	Sub-14
						2-1263	Sub-58	3，4-diClPh	CH2	Single bond	Sub-15
2-1264	Sub-58	3，4-diClPh	CH2	Single bond	Sub-16
						2-1265	Sub-58	3，4-diClPh	CH2	Single bond	Sub-17
2-1266	Sub-58	3，4-diClPh	CH2	Single bond	Sub-18
						2-1267	Sub-58	3，4-diClPh	CH2	Single bond	Sub-19
2-1268	Sub-58	3，4-diClPh	CH2	Single bond	Sub-20
						2-1269	Sub-58	3，4-diClPh	CH2	Single bond	Sub-21
2-1270	Sub-58	3，4-diClPh	CH2	Single bond	Sub-22
						2-1271	Sub-58	3，4-diClPh	CH2	Single bond	Sub-23
2-1272	Sub-58	3，4-diClPh	CH2	Single bond	Sub-24
						2-1273	Sub-58	3，4-diClPh	CH2	Single bond	Sub-25
2-1274	Sub-58	3，4-diClPh	CH2	Single bond	Sub-26

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1275	Sub-58	3，4-diClPh	CH2	Single bond	Sub-27
2-1276	Sub-58	3，4-diClPh	CH2	Single bond	Sub-28
						2-1277	Sub-58	3，4-diClPh	CH2	Single bond	Sub-29
2-1278	Sub-58	3，4-diClPh	CH2	Single bond	Sub-30
						2-1279	Sub-58	3，4-diClPh	CH2	Single bond	Sub-31
2-1280	Sub-58	3，4-diClPh	CH2	Single bond	Sub-32
						2-1281	Sub-58	3，4-diClPh	CH2	Single bond	Sub-65
2-1282	Sub-58	3，4-diClPh	CH2	Single bond	Sub-66
						2-1283	Sub-58	3，4-diClPh	CH2	Single bond	Sub-67
2-1284	Sub-58	3，4-diClPh	CH2	Single bond	Sub-68
						2-1285	Sub-58	3，4-diClPh	CH2	Single bond	Sub-69
2-1286	Sub-58	3，4-diClPh	CH2	Single bond	Sub-70
						2-1287	Sub-58	3，4-diClPh	CH2	Single bond	Sub-71
2-1288	Sub-58	3，4-diClPh	CH2	Single bond	Sub-72
						2-1289	Sub-58	3，4-diClPh	CH2	Single bond	Sub-73
2-1290	Sub-58	3，4-diClPh	CH2	Single bond	Sub-74
						2-1291	Sub-58	3，4-diClPh	CH2	Single bond	Sub-75
2-1292	Sub-58	3，4-diClPh	CH2	Single bond	Sub-76
						2-1293	Sub-58	3，4-diClPh	CH2	Single bond	Sub-77
2-1294	Sub-58	3，4-diClPh	CH2	Single bond	Sub-78
						2-1295	Sub-58	3，4-diClPh	CH2	Single bond	Sub-79
2-1296	Sub-58	3，4-diClPh	CH2	Single bond	Sub-80
						2-1297	Sub-59	3，4-diClPh	CH2	Single bond	Sub-1
2-1298	Sub-59	3，4-diClPh	CH2	Single bond	Sub-2
						2-1299	Sub-59	3，4-diClPh	CH2	Single bond	Sub-3
2-1300	Sub-59	3，4-diClPh	CH2	Single bond	Sub-4

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1301	Sub-59	3，4-diClPh	CH2	Single bond	Sub-5
2-1302	Sub-59	3，4-diClPh	CH2	Single bond	Sub-6
						2-1303	Sub-59	3，4-diClPh	CH2	Single bond	Sub-7
2-1304	Sub-59	3，4-diClPh	CH2	Single bond	Sub-8
						2-1305	Sub-59	3，4-diClPh	CH2	Single bond	Sub-9
2-1306	Sub-59	3，4-diClPh	CH2	Single bond	Sub-10
						2-1307	Sub-59	3，4-diClPh	CH2	Single bond	Sub-11
2-1308	Sub-59	3，4-diClPh	CH2	Single bond	Sub-12
						2-1309	Sub-59	3，4-diClPh	CH2	Single bond	Sub-13
2-1310	Sub-59	3，4-diClPh	CH2	Single bond	Sub-14
						2-1311	Sub-59	3，4-diClPh	CH2	Single bond	Sub-15
2-1312	Sub-59	3，4-diClPh	CH2	Single bond	Sub-16
						2-1313	Sub-59	3，4-diClPh	CH2	Single bond	Sub-17
2-1314	Sub-59	3，4-diClPh	CH2	Single bond	Sub-18
						2-1315	Sub-59	3，4-diClPh	CH2	Single bond	Sub-19
2-1316	Sub-59	3，4-diClPh	CH2	Single bond	Sub-20
						2-1317	Sub-59	3，4-diClPh	CH2	Single bond	Sub-21
2-1318	Sub-59	3，4-diClPh	CH2	Single bond	Sub-22
						2-1319	Sub-59	3，4-diClPh	CH2	Single bond	Sub-23
2-1320	Sub-59	3，4-diClPh	CH2	Single bond	Sub-24
						2-1321	Sub-59	3，4-diClPh	CH2	Single bond	Sub-25
2-1322	Sub-59	3，4-diClPh	CH2	Single bond	Sub-26
						2-1323	Sub-59	3，4-diClPh	CH2	Single bond	Sub-27
2-1324	Sub-59	3，4-diClPh	CH2	Single bond	Sub-28
						2-1325	Sub-59	3，4-diClPh	CH2	Single bond	Sub-29
2-1326	Sub-59	3，4-diClPh	CH2	Single bond	Sub-30

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1327	Sub-59	3，4-diClPh	CH2	Single bond	Sub-31
2-1328	Sub-59	3，4-diClPh	CH2	Single bond	Sub-32
						2-1329	Sub-59	3，4-diClPh	CH2	Single bond	Sub-65
2-1330	Sub-59	3，4-diClPh	CH2	Single bond	Sub-66
						2-1331	Sub-59	3，4-diClPh	CH2	Single bond	Sub-67
2-1332	Sub-59	3，4-diClPh	CH2	Single bond	Sub-68
						2-1333	Sub-59	3，4-diClPh	CH2	Single bond	Sub-69
2-1334	Sub-59	3，4-diClPh	CH2	Single bond	Sub-70
						2-1335	Sub-59	3，4-diClPh	CH2	Single bond	Sub-71
2-1336	Sub-59	3，4-diClPh	CH2	Single bond	Sub-72
						2-1337	Sub-59	3，4-diClPh	CH2	Single bond	Sub-73
2-1338	Sub-59	3，4-diClPh	CH2	Single bond	Sub-74
						2-1339	Sub-59	3，4-diClPh	CH2	Single bond	Sub-75
2-1340	Sub-59	3，4-diClPh	CH2	Single bond	Sub-76
						2-1341	Sub-59	3，4-diClPh	CH2	Single bond	Sub-77
2-1342	Sub-59	3，4-diClPh	CH2	Single bond	Sub-78
						2-1343	Sub-59	3，4-diClPh	CH2	Single bond	Sub-79
2-1344	Sub-59	3，4-diClPh	CH2	Single bond	Sub-80
						2-1345	Sub-82	3，4-diClPh	CH2	Single bond	Sub-1
2-1346	Sub-82	3，4-diClPh	CH2	Single bond	Sub-2
						2-1347	Sub-82	3，4-diClPh	CH2	Single bond	Sub-3
2-1348	Sub-82	3，4-diClPh	CH2	Single bond	Sub-4
						2-1349	Sub-82	3，4-diClPh	CH2	Single bond	Sub-5
2-1350	Sub-82	3，4-diClPh	CH2	Single bond	Sub-6
						2-1351	Sub-82	3，4-diClPh	CH2	Single bond	Sub-7
2-1352	Sub-82	3，4-diClPh	CH2	Single bond	Sub-8

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1353	Sub-82	3，4-diClPh	CH2	Single bond	Sub-9
2-1354	Sub-82	3，4-diClPh	CH2	Single bond	Sub-10
						2-1355	Sub-82	3，4-diClPh	CH2	Single bond	Sub-11
2-1356	Sub-82	3，4-diClPh	CH2	Single bond	Sub-12
						2-1357	Sub-82	3，4-diClPh	CH2	Single bond	Sub-13
2-1358	Sub-82	3，4-diClPh	CH2	Single bond	Sub-14
						2-1359	Sub-82	3，4-diClPh	CH2	Single bond	Sub-15
2-1360	Sub-82	3，4-diClPh	CH2	Single bond	Sub-16
						2-1361	Sub-82	3，4-diClPh	CH2	Single bond	Sub-17
2-1362	Sub-82	3，4-diClPh	CH2	Single bond	Sub-18
						2-1363	Sub-82	3，4-diClPh	CH2	Single bond	Sub-19
2-1364	Sub-82	3，4-diClPh	CH2	Single bond	Sub-20
						2-1365	Sub-82	3，4-diClPh	CH2	Single bond	Sub-21
2-1366	Sub-82	3，4-diClPh	CH2	Single bond	Sub-22
						2-1367	Sub-82	3，4-diClPh	CH2	Single bond	Sub-23
2-1368	Sub-82	3，4-diClPh	CH2	Single bond	Sub-24
						2-1369	Sub-82	3，4-diClPh	CH2	Single bond	Sub-25
2-1370	Sub-82	3，4-diClPh	CH2	Single bond	Sub-26
						2-1371	Sub-82	3，4-diClPh	CH2	Single bond	Sub-27
2-1372	Sub-82	3，4-diClPh	CH2	Single bond	Sub-28
						2-1373	Sub-82	3，4-diClPh	CH2	Single bond	Sub-29
2-1374	Sub-82	3，4-diClPh	CH2	Single bond	Sub-30
						2-1375	Sub-82	3，4-diClPh	CH2	Single bond	Sub-31
2-1376	Sub-82	3，4-diClPh	CH2	Single bond	Sub-32
						2-1377	Sub-82	3，4-diClPh	CH2	Single bond	Sub-65
2-1378	Sub-82	3，4-diClPh	CH2	Single bond	Sub-66

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1379	Sub-82	3，4-diClPh	CH2	Single bond	Sub-67
2-1380	Sub-82	3，4-diClPh	CH2	Single bond	Sub-68
						2-1381	Sub-82	3，4-diClPh	CH2	Single bond	Sub-69
2-1382	Sub-82	3，4-diClPh	CH2	Single bond	Sub-70
						2-1383	Sub-82	3，4-diClPh	CH2	Single bond	Sub-71
2-1384	Sub-82	3，4-diClPh	CH2	Single bond	Sub-72
						2-1385	Sub-82	3，4-diClPh	CH2	Single bond	Sub-73
2-1386	Sub-82	3，4-diClPh	CH2	Single bond	Sub-74
						2-1387	Sub-82	3，4-diClPh	CH2	Single bond	Sub-75
2-1388	Sub-82	3，4-diClPh	CH2	Single bond	Sub-76
						2-1389	Sub-82	3，4-diClPh	CH2	Single bond	Sub-77
2-1390	Sub-82	3，4-diClPh	CH2	Single bond	Sub-78
						2-1391	Sub-82	3，4-diClPh	CH2	Single bond	Sub-79
2-1392	Sub-82	3，4-diClPh	CH2	Single bond	Sub-80
						2-1393	Sub-83	3，4-diClPh	CH2	Single bond	Sub-1
2-1394	Sub-83	3，4-diClPh	CH2	Single bond	Sub-2
						2-1395	Sub-83	3，4-diClPh	CH2	Single bond	Sub-3
2-1396	Sub-83	3，4-diClPh	CH2	Single bond	Sub-4
						2-1397	Sub-83	3，4-diClPh	CH2	Single bond	Sub-5
2-1398	Sub-83	3，4-diClPh	CH2	Single bond	Sub-6
						2-1399	Sub-83	3，4-diClPh	CH2	Single bond	Sub-7
2-1400	Sub-83	3，4-diClPh	CH2	Single bond	Sub-8
						2-1401	Sub-83	3，4-diClPh	CH2	Single bond	Sub-9
2-1402	Sub-83	3，4-diClPh	CH2	Single bond	Sub-10
						2-1403	Sub-83	3，4-diClPh	CH2	Single bond	Sub-11
2-1404	Sub-83	3，4-diClPh	CH2	Single bond	Sub-12

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1405	Sub-83	3，4-diClPh	CH2	Single bond	Sub-13
2-1406	Sub-83	3，4-diClPh	CH2	Single bond	Sub-14
						2-1407	Sub-83	3，4-diClPh	CH2	Single bond	Sub-15
2-1408	Sub-83	3，4-diClPh	CH2	Single bond	Sub-16
						2-1409	Sub-83	3，4-diClPh	CH2	Single bond	Sub-17
2-1410	Sub-83	3，4-diClPh	CH2	Single bond	Sub-18
						2-1411	Sub-83	3，4-diClPh	CH2	Single bond	Sub-19
2-1412	Sub-83	3，4-diClPh	CH2	Single bond	Sub-20
						2-1413	Sub-83	3，4-diClPh	CH2	Single bond	Sub-21
2-1414	Sub-83	3，4-diClPh	CH2	Single bond	Sub-22
						2-1415	Sub-83	3，4-diClPh	CH2	Single bond	Sub-23
2-1416	Sub-83	3，4-diClPh	CH2	Single bond	Sub-24
						2-1417	Sub-83	3，4-diClPh	CH2	Single bond	Sub-25
2-1418	Sub-83	3，4-diClPh	CH2	Single bond	Sub-26
						2-1419	Sub-83	3，4-diClPh	CH2	Single bond	Sub-27
2-1420	Sub-83	3，4-diClPh	CH2	Single bond	Sub-28
						2-1421	Sub-83	3，4-diClPh	CH2	Single bond	Sub-29
2-1422	Sub-83	3，4-diClPh	CH2	Single bond	Sub-30
						2-1423	Sub-83	3，4-diClPh	CH2	Single bond	Sub-31
2-1424	Sub-83	3，4-diClPh	CH2	Single bond	Sub-32
						2-1425	Sub-83	3，4-diClPh	CH2	Single bond	Sub-65
2-1426	Sub-83	3，4-diClPh	CH2	Single bond	Sub-66
						2-1427	Sub-83	3，4-diClPh	CH2	Single bond	Sub-67
2-1428	Sub-83	3，4-diClPh	CH2	Single bond	Sub-68
						2-1429	Sub-83	3，4-diClPh	CH2	Single bond	Sub-69
2-1430	Sub-83	3，4-diClPh	CH2	Single bond	Sub-70

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1431	Sub-83	3，4-diClPh	CH2	Single bond	Sub-71
2-1432	Sub-83	3，4-diClPh	CH2	Single bond	Sub-72
						2-1433	Sub-83	3，4-diClPh	CH2	Single bond	Sub-73
2-1434	Sub-83	3，4-diClPh	CH2	Single bond	Sub-74
						2-1435	Sub-83	3，4-diClPh	CH2	Single bond	Sub-75
2-1436	Sub-83	3，4-diClPh	CH2	Single bond	Sub-76
						2-1437	Sub-83	3，4-diClPh	CH2	Single bond	Sub-77
2-1438	Sub-83	3，4-diClPh	CH2	Single bond	Sub-78
						2-1439	Sub-83	3，4-diClPh	CH2	Single bond	Sub-79
2-1440	Sub-83	3，4-diClPh	CH2	Single bond	Sub-80
						2-1441	Sub-61	3，4-diClPh	CH2	Single bond	Sub-1
2-1442	Sub-61	3，4-diClPh	CH2	Single bond	Sub-2
						2-1443	Sub-61	3，4-diClPh	CH2	Single bond	Sub-3
2-1444	Sub-61	3，4-diClPh	CH2	Single bond	Sub-4
						2-1445	Sub-61	3，4-diClPh	CH2	Single bond	Sub-5
2-1446	Sub-61	3，4-diClPh	CH2	Single bond	Sub-6
						2-1447	Sub-61	3，4-diClPh	CH2	Single bond	Sub-7
2-1448	Sub-61	3，4-diClPh	CH2	Single bond	Sub-8
						2-1449	Sub-61	3，4-diClPh	CH2	Single bond	Sub-9
2-1450	Sub-61	3，4-diClPh	CH2	Single bond	Sub-10
						2-1451	Sub-61	3，4-diClPh	CH2	Single bond	Sub-11
2-1452	Sub-61	3，4-diClPh	CH2	Single bond	Sub-12
						2-1453	Sub-61	3，4-diClPh	CH2	Single bond	Sub-13
2-1454	Sub-61	3，4-diClPh	CH2	Single bond	Sub-14
						2-1455	Sub-61	3，4-diClPh	CH2	Single bond	Sub-15
2-1456	Sub-61	3，4-diClPh	CH2	Single bond	Sub-16

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1457	Sub-61	3，4-diClPh	CH2	Single bond	Sub-17
2-1458	Sub-61	3，4-diClPh	CH2	Single bond	Sub-18
						2-1459	Sub-61	3，4-diClPh	CH2	Single bond	Sub-19
2-1460	Sub-61	3，4-diClPh	CH2	Single bond	Sub-20
						2-1461	Sub-61	3，4-diClPh	CH2	Single bond	Sub-21
2-1462	Sub-61	3，4-diClPh	CH2	Single bond	Sub-22
						2-1463	Sub-61	3，4-diClPh	CH2	Single bond	Sub-23
2-1464	Sub-61	3，4-diClPh	CH2	Single bond	Sub-24
						2-1465	Sub-61	3，4-diClPh	CH2	Single bond	Sub-25
2-1466	Sub-61	3，4-diClPh	CH2	Single bond	Sub-26
						2-1467	Sub-61	3，4-diClPh	CH2	Single bond	Sub-27
2-1468	Sub-61	3，4-diClPh	CH2	Single bond	Sub-28
						2-1469	Sub-61	3，4-diClPh	CH2	Single bond	Sub-29
2-1470	Sub-61	3，4-diClPh	CH2	Single bond	Sub-30
						2-1471	Sub-61	3，4-diClPh	CH2	Single bond	Sub-31
2-1472	Sub-61	3，4-diClPh	CH2	Single bond	Sub-32
						2-1473	Sub-61	3，4-diClPh	CH2	Single bond	Sub-65
2-1474	Sub-61	3，4-diClPh	CH2	Single bond	Sub-66
						2-1475	Sub-61	3，4-diClPh	CH2	Single bond	Sub-67
2-1476	Sub-61	3，4-diClPh	CH2	Single bond	Sub-68
						2-1477	Sub-61	3，4-diClPh	CH2	Single bond	Sub-69
2-1478	Sub-61	3，4-diClPh	CH2	Single bond	Sub-70
						2-1479	Sub-61	3，4-diClPh	CH2	Single bond	Sub-71
2-1480	Sub-61	3，4-diClPh	CH2	Single bond	Sub-72
						2-1481	Sub-61	3，4-diClPh	CH2	Single bond	Sub-73
2-1482	Sub-61	3，4-diClPh	CH2	Single bond	Sub-74

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1483	Sub-61	3，4-diClPh	CH2	Single bond	Sub-75
2-1484	Sub-61	3，4-diClPh	CH2	Single bond	Sub-76
						2-1485	Sub-61	3，4-diClPh	CH2	Single bond	Sub-77
2-1486	Sub-61	3，4-diClPh	CH2	Single bond	Sub-78
						2-1487	Sub-61	3，4-diClPh	CH2	Single bond	Sub-79
2-1488	Sub-61	3，4-diClPh	CH2	Single bond	Sub-80
						2-1489	Sub-60	3，4-diClPh	CH2	Single bond	Sub-1
2-1490	Sub-60	3，4-diClPh	CH2	Single bond	Sub-2
						2-1491	Sub-60	3，4-diClPh	CH2	Single bond	Sub-3
2-1492	Sub-60	3，4-diClPh	CH2	Single bond	Sub-4
						2-1493	Sub-60	3，4-diClPh	CH2	Single bond	Sub-5
2-1494	Sub-60	3，4-diClPh	CH2	Single bond	Sub-6
						2-1495	Sub-60	3，4-diClPh	CH2	Single bond	Sub-7
2-1496	Sub-60	3，4-diClPh	CH2	Single bond	Sub-8
						2-1497	Sub-60	3，4-diClPh	CH2	Single bond	Sub-9
2-1498	Sub-60	3，4-diClPh	CH2	Single bond	Sub-10
						2-1499	Sub-60	3，4-diClPh	CH2	Single bond	Sub-11
2-1500	Sub-60	3，4-diClPh	CH2	Single bond	Sub-12
						2-1501	Sub-60	3，4-diClPh	CH2	Single bond	Sub-13
2-1502	Sub-60	3，4-diClPh	CH2	Single bond	Sub-14
						2-1503	Sub-60	3，4-diClPh	CH2	Single bond	Sub-15
2-1504	Sub-60	3，4-diClPh	CH2	Single bond	Sub-16
						2-1505	Sub-60	3，4-diClPh	CH2	Single bond	Sub-17
2-1506	Sub-60	3，4-diClPh	CH2	Single bond	Sub-18
						2-1507	Sub-60	3，4-diClPh	CH2	Single bond	Sub-19
2-1508	Sub-60	3，4-diClPh	CH2	Single bond	Sub-20

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1509	Sub-60	3，4-diClPh	CH2	Single bond	Sub-21
2-1510	Sub-60	3，4-diClPh	CH2	Single bond	Sub-22
						2-1511	Sub-60	3，4-diClPh	CH2	Single bond	Sub-23
2-1512	Sub-60	3，4-diClPh	CH2	Single bond	Sub-24
						2-1513	Sub-60	3，4-diClPh	CH2	Single bond	Sub-25
2-1514	Sub-60	3，4-diClPh	CH2	Single bond	Sub-26
						2-1515	Sub-60	3，4-diClPh	CH2	Single bond	Sub-27
2-1516	Sub-60	3，4-diClPh	CH2	Single bond	Sub-28
						2-1517	Sub-60	3，4-diClPh	CH2	Single bond	Sub-29
2-1518	Sub-60	3，4-diClPh	CH2	Single bond	Sub-30
						2-1519	Sub-60	3，4-diClPh	CH2	Single bond	Sub-31
2-1520	Sub-60	3，4-diClPh	CH2	Single bond	Sub-32
						2-1521	Sub-60	3，4-diClPh	CH2	Single bond	Sub-65
2-1522	Sub-60	3，4-diClPh	CH2	Single bond	Sub-66
						2-1523	Sub-60	3，4-diClPh	CH2	Single bond	Sub-67
2-1524	Sub-60	3，4-diClPh	CH2	Single bond	Sub-68
						2-1525	Sub-60	3，4-diClPh	CH2	Single bond	Sub-69
2-1526	Sub-60	3，4-diClPh	CH2	Single bond	Sub-70
						2-1527	Sub-60	3，4-diClPh	CH2	Single bond	Sub-71
2-1528	Sub-60	3，4-diClPh	CH2	Single bond	Sub-72
						2-1529	Sub-60	3，4-diClPh	CH2	Single bond	Sub-73
2-1530	Sub-60	3，4-diClPh	CH2	Single bond	Sub-74
						2-1531	Sub-60	3，4-diClPh	CH2	Single bond	Sub-75
2-1532	Sub-60	3，4-diClPh	CH2	Single bond	Sub-76
						2-1533	Sub-60	3，4-diClPh	CH2	Single bond	Sub-77
2-1534	Sub-60	3，4-diClPh	CH2	Single bond	Sub-78

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1535	Sub-60	3，4-diClPh	CH2	Single bond	Sub-79
2-1536	Sub-60	3，4-diClPh	CH2	Single bond	Sub-80
						2-1537	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-1538	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-1539	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-1540	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-1541	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-1542	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-1543	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-1544	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-1545	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-1546	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-1547	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-1548	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-1549	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-1550	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-1551	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-1552	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-1553	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-1554	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-1555	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-1556	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-1557	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-1558	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-1559	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-1560	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-24

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1561	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-1562	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-1563	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-1564	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-1565	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-1566	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-1567	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-1568	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-1569	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-1570	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-1571	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-1572	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-1573	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-1574	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-1575	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-1576	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-1577	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-1578	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-1579	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-1580	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-1581	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-1582	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-1583	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-1584	Sub-33	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-1585	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-1586	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-2

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1587	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-1588	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-1589	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-1590	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-1591	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-1592	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-1593	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-1594	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-1595	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-1596	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-1597	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-1598	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-1599	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-1600	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-16O1	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-1602	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-1603	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-1604	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-1605	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-1606	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-1607	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-1608	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-1609	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-1610	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-1611	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-1612	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-28

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1613	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-1614	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-1615	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-1616	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-1617	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-1618	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-1619	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-1620	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-1621	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-1622	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-1623	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-1624	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-1625	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-1626	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-1627	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-1628	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-1629	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-1630	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-1631	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-1632	Sub-34	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-1633	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-1634	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-1635	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-1636	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-1637	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-1638	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-6

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1639	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-1640	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-1641	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-1642	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-1643	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-1644	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-1645	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-1646	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-1647	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-1648	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-1649	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-1650	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-1651	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-1652	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-1653	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-1654	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-1655	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-1656	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-1657	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-1658	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-1659	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-1660	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-1661	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-1662	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-1663	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-1664	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-32

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1665	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-1666	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-1667	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-1668	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-1669	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-1670	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-1671	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-1672	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-1673	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-1674	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-1675	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-1676	Sub-35	3，4-diClPh	CO	Single bondor CH2	Sub-76
						2-1677	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-1678	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-1679	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-1680	Sub-35	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-1681	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-1682	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-1683	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-1684	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-1685	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-1686	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-1687	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-1688	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-1689	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-1690	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-10

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1691	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-1692	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-1693	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-1694	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-1695	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-1696	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-1697	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-1698	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-1699	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-1700	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-1701	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-1702	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-1703	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-1704	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-1705	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-1706	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-1707	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-1708	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-1709	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-1710	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-1711	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-1712	Sub-36	3，4-diClPh	C0	Single bond or CH2	Sub-32
						2-1713	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-1714	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-1715	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-1716	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-68

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1717	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-1718	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-1719	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-1720	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-1721	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-1722	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-1723	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-1724	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-1725	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-1726	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-1727	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-1728	Sub-36	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-1729	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-1730	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-1731	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-1732	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-1733	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-1734	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-1735	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-1736	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-1737	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-1738	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-1739	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-1740	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-1741	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-1742	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-14

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1743	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-1744	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-1745	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-1746	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-1747	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-1748	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-1749	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-1750	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-1751	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-1752	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-1753	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-1754	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-1755	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-1756	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-1757	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-1758	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-1759	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-1760	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-1761	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-1762	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-1763	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-1764	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-1765	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-1766	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-1767	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-1768	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-72

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1769	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-1770	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-1771	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-1772	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-1773	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-1774	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-1775	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-1776	Sub-37	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-1777	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-1778	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-1779	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-1780	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-1781	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-1782	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-1783	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-1784	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-1785	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-1786	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-1787	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-1788	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-1789	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-1790	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-1791	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-1792	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-1793	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-1794	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-18

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1795	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-1796	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-1797	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-1798	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-1799	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-1800	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-1801	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-1802	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-1803	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-1804	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-1805	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-1806	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-1807	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-1808	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-1809	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-1810	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-1811	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-1812	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-1813	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-1814	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-1815	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-1816	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-1817	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-1818	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-1819	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-1820	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-76

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1821	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-1822	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-1823	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-1824	Sub-38	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-1825	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-1826	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-1827	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-1828	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-1829	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-1830	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-1831	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-1832	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-1833	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-1834	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-1835	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-1836	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-1837	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-1838	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-1839	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-1840	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-1841	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-1842	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-1843	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-1844	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-1845	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-1846	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-22

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1847	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-1848	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-1849	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-1850	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-1851	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-1852	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-1853	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-1854	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-1855	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-1856	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-1857	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-1858	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-1859	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-1860	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-1861	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-1862	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-1863	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-1864	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-1865	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-1866	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-1867	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-1868	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-1869	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-1870	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-1871	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-1872	Sub-39	3，4-diClPh	CO	Single bond or CH2	Sub-80

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1873	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-1874	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-1875	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-1876	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-1877	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-1878	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-1879	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-1880	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-1881	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-1882	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-1883	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-1884	Sub-40	3，4-diClPh	CO	Single bond or CH2	Suh-12
						2-1885	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-1886	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-1887	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-1888	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-1889	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-1890	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-1891	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-1892	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-1893	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-1894	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-1895	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-1896	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-1897	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-1898	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-26

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1899	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-1900	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-1901	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-1902	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-1903	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-1904	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-1905	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-1906	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-1907	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-1908	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-1909	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-1910	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-1911	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-1912	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-1913	Sub-40	3，4-diClPh	C0	Single bond or CH2	Sub-73
2-1914	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-1915	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-1916	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-1917	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-1918	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-1919	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-1920	Sub-40	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-1921	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-1922	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-1923	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-1924	Sub-41	3，4-diClPh	CO	SheetKey or CH2	Sub-4

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1925	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-1926	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-1927	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-1928	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-1929	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-1930	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-1931	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-1932	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-1933	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-1934	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-1935	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-1936	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-1937	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-1938	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-1939	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-1940	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-1941	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-1942	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-1943	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-1944	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-1945	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-1946	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-1947	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-1948	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-1949	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-1950	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-30

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1951	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-1952	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-1953	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-1954	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-1955	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-1956	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-1957	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-1958	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-1959	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-1960	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-1961	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-1962	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-1963	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-1964	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-1965	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-1966	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-1967	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-1968	Sub-41	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-1969	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-1970	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-1971	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-1972	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-1973	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-1974	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-1975	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-1976	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-8

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-1977	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-1978	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-1979	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-1980	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-1981	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-1982	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-1983	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-1984	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-1985	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-1986	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-1987	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-1988	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-1989	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-1990	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-1991	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-1992	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-1993	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-1994	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-1995	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-1996	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-1997	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-1998	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-1999	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2000	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2001	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2002	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-66

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2003	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2004	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2005	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2006	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2007	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2008	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2009	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2010	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2011	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2012	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2013	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2014	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2015	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2016	Sub-42	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2017	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2018	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2019	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2020	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2021	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2022	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2023	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2024	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2025	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2026	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2027	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2028	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-12

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2029	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2030	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2031	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2032	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2033	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2034	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2035	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2036	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2037	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2038	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2039	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2040	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2041	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2042	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2043	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2044	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2045	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2046	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2047	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2048	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2049	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2050	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2051	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2052	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2053	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2054	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-70

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2055	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2056	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2057	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2058	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2059	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2060	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2061	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2062	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2063	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2064	Sub-43	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2065	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2066	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2067	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2068	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2069	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2070	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2071	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2072	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2073	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2074	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2075	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2076	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2077	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2078	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2079	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2080	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-16

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2081	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2082	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2083	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2084	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2085	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2086	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2087	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2088	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2089	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2090	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2091	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2092	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2093	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2094	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2095	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2096	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2097	Sub-44	3，4-diClPh	C0	Single bond or CH2	Sub-65
2-2098	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2099	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2100	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2101	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2102	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2103	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2104	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2105	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2106	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-74

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2107	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2108	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2109	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2110	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2111	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2112	Sub-44	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2113	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2114	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2115	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2116	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2117	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2118	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2119	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2120	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2121	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2122	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-1O
						2-2123	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2124	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2125	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2126	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2127	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2128	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2129	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2130	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2131	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2132	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-20

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2133	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2134	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2135	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2136	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2137	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2138	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2139	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2140	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2141	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2142	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2143	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2144	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2145	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2146	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2147	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2148	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2149	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2150	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2151	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2152	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2153	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2154	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2155	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2156	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2157	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2158	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-78

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2159	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2160	Sub-45	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2161	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2162	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2163	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2164	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2165	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2166	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2167	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2168	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2169	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2170	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2171	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2172	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2173	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2174	Sub46	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2175	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2176	Sub46	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2177	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2178	Sub-46	3，4-diClPh	CO	Single key orCH2	Sub-18
						2-2179	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2180	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2181	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2182	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2183	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2184	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-24

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2185	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2186	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2187	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2188	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2189	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2190	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2191	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2192	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2193	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2194	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2195	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2196	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2197	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2198	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2199	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2200	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2201	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2202	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2203	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2204	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2205	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2206	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2207	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2208	Sub-46	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2209	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2210	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-2

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2211	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2212	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2213	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2214	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2215	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2216	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2217	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2218	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2219	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2220	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2221	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2222	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2223	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2224	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2225	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2226	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2227	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2228	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2229	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2230	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2231	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2232	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2233	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2234	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2235	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2236	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-28

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2237	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2238	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2239	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2240	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2241	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2242	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2243	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2244	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2245	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2246	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2247	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2248	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2249	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2250	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2251	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2252	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2253	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2254	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2255	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2256	Sub-47	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2257	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2258	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2259	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2260	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2261	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2262	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-6

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2263	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2264	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2265	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2266	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2267	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2268	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2269	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2270	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2271	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2272	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2273	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2274	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2275	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2276	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2277	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2278	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2279	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2280	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2281	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2282	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2283	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2284	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2285	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2286	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2287	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2288	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-32

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2289	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2290	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2291	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2292	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2293	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2294	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2295	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2296	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2297	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2298	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2299	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2300	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2301	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2302	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2303	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2304	Sub-81	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2305	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2306	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2307	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2308	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2309	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2310	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2311	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2312	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2313	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2314	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-10

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2315	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2316	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2317	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2318	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2319	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-232O	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2321	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2322	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2323	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2324	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2325	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2326	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2327	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2328	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2329	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2330	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2331	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2332	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2333	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2334	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2335	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2336	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2337	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2338	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2339	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2340	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-68

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2341	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2342	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2343	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2344	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2345	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2346	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2347	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2348	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2349	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2350	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2351	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2352	Sub-48	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2353	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2354	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2355	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2356	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2357	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2358	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2359	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2360	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2361	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2362	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2363	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2364	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2365	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2366	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-14

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2367	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2368	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2369	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2370	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2371	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2372	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2373	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2374	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2375	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2376	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2377	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2378	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2379	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2380	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2381	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2382	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2383	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2384	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2385	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2386	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2387	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2388	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2389	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2390	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2391	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2392	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-72

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2393	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2394	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2395	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2396	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2397	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2398	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2399	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2400	Sub-49	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2401	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2402	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2403	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2404	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2405	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2406	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2407	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2408	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2409	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2410	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2411	Sub-50	3，4-diClPh	C0	Single bond or CH2	Sub-11
2-2412	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2413	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2414	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2415	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2416	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2417	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2418	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-18

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2419	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2420	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2421	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2422	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2423	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2424	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2425	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2426	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2427	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2428	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2429	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2430	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2431	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2432	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2433	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2434	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2435	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2436	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2437	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2438	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2439	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2440	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2441	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2442	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2443	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2444	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-76

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2445	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2446	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2447	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2448	Sub-50	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2449	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2450	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2451	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2452	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2453	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2454	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2455	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2456	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2457	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2458	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2459	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2460	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2461	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2462	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2463	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2464	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2465	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2466	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2467	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2468	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2469	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2470	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-22

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2471	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2472	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2473	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2474	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2475	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2476	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2477	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2478	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2479	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2480	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2481	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2482	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2483	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2484	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2485	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2486	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2487	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2488	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2489	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2490	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2491	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2492	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2493	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2494	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2495	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2496	Sub-51	3，4-diClPh	CO	Single bond or CH2	Sub-80

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2497	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2498	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2499	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2500	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2501	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2502	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2503	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2504	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2505	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2506	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2507	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2508	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2509	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2510	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2511	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2512	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2513	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2514	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2515	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2516	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2517	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2518	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2519	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2520	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2521	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2522	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-26

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2523	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2524	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2525	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2526	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2527	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2528	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2529	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2530	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2531	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2532	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2533	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2534	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2535	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2536	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2537	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2538	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2539	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2540	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2541	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2542	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2543	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2544	Sub-52	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2545	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2546	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2547	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2548	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-4

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2549	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2550	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2551	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2552	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2553	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2554	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2555	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2556	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2557	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2558	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2559	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2560	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2561	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2562	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2563	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2564	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2565	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2566	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2567	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2568	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2569	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2570	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2571	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2572	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2573	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2574	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-30

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2575	Sub-53	3，4-diClPh	CO	SheetKey or CH2	Sub-31
2-2576	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2577	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2578	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2579	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2580	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2581	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2582	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2583	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2584	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2585	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2586	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2587	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2588	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2589	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2590	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2591	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2592	Sub-53	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2593	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2594	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2595	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2596	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2597	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2598	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2599	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2600	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-8

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2601	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2602	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-1O
						2-2603	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2604	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2605	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2606	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2607	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2608	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2609	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2610	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2611	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2612	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2613	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2614	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2615	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2616	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2617	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2618	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2619	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2620	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2621	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2622	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2623	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2624	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2625	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2626	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-66

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2627	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2628	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2629	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2630	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2631	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2632	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2633	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2634	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2635	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2636	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2637	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2638	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2639	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2640	Sub-54	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2641	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2642	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2643	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2644	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2645	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2646	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2647	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2648	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2649	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2650	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2651	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2652	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-12

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2653	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2654	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2655	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2656	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2657	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2658	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2659	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2660	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2661	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2662	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2663	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2664	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2665	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2666	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2667	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2668	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2669	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2670	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2671	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2672	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2673	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2674	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2675	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2676	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2677	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2678	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-70

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2679	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2680	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2681	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2682	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2683	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2684	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2685	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2686	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2687	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2688	Sub-55	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2689	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2690	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2691	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2692	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2693	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2694	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2695	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2696	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2697	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2698	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2699	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2700	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2701	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2702	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2703	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2704	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-16

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2705	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2706	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2707	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2708	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2709	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2710	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2711	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2712	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2713	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2714	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2715	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2716	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2717	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2718	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2719	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2720	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2721	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2722	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2723	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2724	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2725	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2726	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2727	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2728	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2729	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2730	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-74

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2731	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2732	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2733	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2734	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2735	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2736	Sub-56	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2737	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2738	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2739	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2740	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2741	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2742	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2743	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2744	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2745	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2746	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2747	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2748	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2749	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2750	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2751	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2752	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2753	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2754	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2755	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2756	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-20

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2757	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2758	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2759	Sub-57	3，4-diClPh	CO	SheetKey or CH2	Sub-23
2-2760	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2761	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2762	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2763	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2764	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2765	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2766	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2767	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2768	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2769	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2770	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2771	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2772	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2773	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2774	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2775	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2776	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2777	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2778	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2779	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2780	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2781	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2782	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-78

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2783	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2784	Sub-57	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2785	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2786	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2787	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2788	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2789	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2790	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2791	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2792	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2793	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2794	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2795	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2796	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2797	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2798	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2799	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2800	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2801	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2802	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2803	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2804	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2805	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2806	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2807	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2808	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-24

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2809	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2810	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2811	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2812	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2813	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2814	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2815	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2816	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2817	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2818	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2819	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2820	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2821	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2822	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2823	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2824	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2825	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2826	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2827	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2828	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2829	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2830	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2831	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2832	Sub-58	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2833	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2834	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-2

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2835	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2836	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2837	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2838	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2839	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2840	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2841	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2842	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-1O
						2-2843	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2844	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2845	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2846	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2847	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2848	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2849	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2850	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2851	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2852	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2853	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2854	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2855	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2856	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2857	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2858	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2859	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2860	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-28

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2861	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2862	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2863	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2864	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-2865	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2866	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2867	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2868	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2869	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2870	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2871	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2872	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2873	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2874	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2875	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2876	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2877	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2878	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2879	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2880	Sub-59	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2881	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2882	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2883	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2884	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2885	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2886	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-6

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2887	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2888	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2889	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2890	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2891	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2892	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2893	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2894	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2895	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2896	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2897	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2898	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2899	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2900	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2901	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2902	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2903	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2904	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2905	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2906	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2907	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2908	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2909	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2910	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2911	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2912	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-32

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2913	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2914	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2915	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2916	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-2917	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2918	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2919	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2920	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2921	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2922	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2923	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2924	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2925	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2926	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2927	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2928	Sub-82	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2929	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2930	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2931	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2932	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2933	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2934	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2935	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2936	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2937	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2938	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-10

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2939	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2940	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2941	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2942	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-2943	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2944	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2945	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2946	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2947	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2948	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-2O
						2-2949	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2950	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2951	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-2952	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-2953	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-2954	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-2955	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-2956	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-2957	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-2958	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-2959	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-2960	Sub-83	3，4-diClPh	C0	Single bond or CH2	Sub-32
						2-2961	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-2962	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-2963	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-2964	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-68

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2965	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-2966	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-2967	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-2968	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-2969	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-2970	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-2971	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-2972	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-2973	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-2974	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-2975	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-2976	Sub-83	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-2977	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-2978	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-2979	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-2980	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-2981	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-2982	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-2983	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-2984	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-2985	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-2986	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-2987	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-2988	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-2989	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-2990	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-14

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-2991	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-2992	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-2993	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-2994	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-18
						2-2995	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-2996	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-2997	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-2998	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-2999	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-3000	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-24
						2-3001	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-25
2-3002	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-3003	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-3004	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-3005	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-3006	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-3007	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-3008	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-3009	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-3010	Sub-61	3，4-diClPh	CO	Single bond or CH 2	Sub-66
						2-3011	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-3012	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-3013	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-3014	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-3015	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-3016	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-72

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3017	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-3018	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-3019	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-3020	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-76
						2-3021	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-3022	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-3023	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-3024	Sub-61	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-3025	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-1
2-3026	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-2
						2-3027	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-3
2-3028	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-4
						2-3029	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-5
2-3030	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-6
						2-3031	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-7
2-3032	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-8
						2-3033	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-9
2-3034	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-10
						2-3035	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-11
2-3036	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-12
						2-3037	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-13
2-3038	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-14
						2-3039	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-15
2-3040	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-16
						2-3041	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-17
2-3042	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-18

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3043	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-19
2-3044	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-20
						2-3045	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-21
2-3046	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-22
						2-3047	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-23
2-3048	Sub-60	3，4-diCiPh	CO	Single bond or CH2	Sub-24
						2-3049	Sub-60	3，4-diClPh	C0	Single bond or CH2	Sub-25
2-3050	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-26
						2-3051	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-27
2-3052	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-28
						2-3053	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-29
2-3054	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-30
						2-3055	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-31
2-3056	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-32
						2-3057	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-65
2-3058	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-66
						2-3059	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-67
2-3060	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-68
						2-3061	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-69
2-3062	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-70
						2-3063	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-71
2-3064	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-72
						2-3065	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-73
2-3066	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-74
						2-3067	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-75
2-3068	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-76

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3069	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-77
2-3070	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-78
						2-3071	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-79
2-3072	Sub-60	3，4-diClPh	CO	Single bond or CH2	Sub-80
						2-3073	Sub-33	3，4-diClPh	SO2	Single bond	Sub-1
2-3074	Sub-33	3，4-diClPh	SO2	Single bond	Sub-2
						2-3075	Sub-33	3，4-diClPh	SO2	Single bond	Sub-3
2-3076	Sub-33	3，4-diClPh	SO2	Single bond	Sub-4
						2-3077	Sub-33	3，4-diClPh	SO2	Single bond	Sub-5
2-3078	Sub-33	3，4-diClPh	SO2	Single bond	Sub-6
						2-3079	Sub-33	3，4-diClPh	SO2	Single bond	Sub-7
2-3080	Sub-33	3，4-diClPh	SO2	Single bond	Sub-8
						2-3081	Sub-33	3，4-diClPh	SO2	Single bond	Sub-9
2-3082	Sub-33	3，4-diClPh	SO2	Single bond	Sub-10
						2-3083	Sub-33	3，4-diClPh	SO2	Single bond	Sub-11
2-3084	Sub-33	3，4-diClPh	SO2	Single bond	Sub-12
						2-3085	Sub-33	3，4-diClPh	SO2	Single bond	Sub-13
2-3086	Sub-33	3，4-diClPh	SO2	Single bond	Sub-14
						2-3087	Sub-33	3，4-diClPh	SO2	Single bond	Sub-15
2-3088	Sub-33	3，4-diClPh	SO2	Single bond	Sub-16
						2-3089	Sub-33	3，4-diClPh	SO2	Single bond	Sub-17
2-3090	Sub-33	3，4-diClPh	SO2	Single bond	Sub-18
						2-3091	Sub-33	3，4-diClPh	SO2	Single bond	Sub-19
2-3092	Sub-33	3，4-diClPh	SO2	Single bond	Sub-20
						2-3093	Sub-33	3，4-diClPh	SO2	Single bond	Sub-21
2-3094	Sub-33	3，4-diClPh	SO2	Single bond	Sub-22

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3095	Sub-33	3，4-diClPh	SO2	Single bond	Sub-23
2-3096	Sub-33	3，4-diClPh	SO2	Single bond	Sub-24
						2-3097	Sub-33	3，4-diClPh	SO2	Single bond	Sub-25
2-3098	Sub-33	3，4-diClPh	SO2	Single bond	Sub-26
						2-3099	Sub-33	3，4-diClPh	SO2	Single bond	Sub-27
2-3100	Sub-33	3，4-diClPh	SO2	Single bond	Sub-28
						2-3101	Sub-33	3，4-diClPh	SO2	Single bond	Sub-29
2-3102	Sub-33	3，4-diClPh	SO2	Single bond	Sub-30
						2-3103	Sub-33	3，4-diClPh	SO2	Single bond	Sub-31
2-3104	Sub-33	3，4-diClPh	SO2	Single bond	Sub-32
						2-3105	Sub-33	3，4-diClPh	SO2	Single bond	Sub-65
2-3106	Sub-33	3，4-diClPh	SO2	Single bond	Sub-66
						2-3107	Sub-33	3，4-diClPh	SO2	Single bond	Sub-67
2-3108	Sub-33	3，4-diClPh	SO2	Single bond	Sub-68
						2-3109	Sub-33	3，4-diClPh	SO2	Single bond	Sub-69
2-3110	Sub-33	3，4-diClPh	SO2	Single bond	Sub-70
						2-3111	Sub-33	3，4-diClPh	SO2	Single bond	Sub-71
2-3112	Sub-33	3，4-diClPh	SO2	Single bond	Sub-72
						2-3113	Sub-33	3，4-diClPh	SO2	Single bond	Sub-73
2-3114	Sub-33	3，4-diClPh	SO2	Single bond	Sub-74
						2-3115	Sub-33	3，4-diClPh	SO2	Single bond	Sub-75
2-3116	Sub-33	3，4-diClPh	SO2	Single bond	Sub-76
						2-3117	Sub-33	3，4-diClPh	SO2	Single bond	Sub-77
2-3118	Sub-33	3，4-diClPh	SO2	Single bond	Sub-78
						2-3119	Sub-33	3，4-diClPh	SO2	Single bond	Sub-79
2-3120	Sub-33	3，4-diClPh	SO2	Single bond	Sub-80

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3121	Sub-34	3，4-diClPh	SO2	Single bond	Sub-1
2-3122	Sub-34	3，4-diClPh	SO2	Single bond	Sub-2
						2-3123	Sub-34	3，4-diClPh	SO2	Single bond	Sub-3
2-3124	Sub-34	3，4-diClPh	SO2	Single bond	Sub-4
						2-3125	Sub-34	3，4-diClPh	SO2	Single bond	Sub-5
2-3126	Sub-34	3，4-diClPh	SO2	Single bond	Sub-6
						2-3127	Sub-34	3，4-diClPh	SO2	Single bond	Sub-7
2-3128	Sub-34	3，4-diClPh	SO2	Single bond	Sub-8
						2-3129	Sub-34	3，4-diClPh	SO2	Single bond	Sub-9
2-3130	Sub-34	3，4-diClPh	SO2	Single bond	Sub-10
						2-3131	Sub-34	3，4-diClPh	SO2	Single bond	Sub-11
2-3132	Sub-34	3，4-diClPh	SO2	Single bond	Sub-12
						2-3133	Sub-34	3，4-diClPh	SO2	Single bond	Sub-13
2-3134	Sub-34	3，4-diClPh	SO2	Single bond	Sub-14
						2-3135	Sub-34	3，4-diClPh	SO2	Single bond	Sub-15
2-3136	Sub-34	3，4-diClPh	SO2	Single bond	Sub-16
						2-3137	Sub-34	3，4-diClPh	SO2	Single bond	Sub-17
2-3138	Sub-34	3，4-diClPh	SO2	Single bond	Sub-18
						2-3139	Sub-34	3，4-diClPh	SO2	Single bond	Sub-19
2-3140	Sub-34	3，4-diClPh	SO2	Single bond	Sub-20
						2-3141	Sub-34	3，4-diClPh	SO2	Single bond	Sub-21
2-3142	Sub-34	3，4-diClPh	SO2	Single bond	Sub-22
						2-3143	Sub-34	3，4-diClPh	SO2	Single bond	Sub-23
2-3144	Sub-34	3，4-diClPh	SO2	Single bond	Sub-24
						2-3145	Sub-34	3，4-diClPh	SO2	Single bond	Sub-25
2-3146	Sub-34	3，4-diClPh	SO2	Single bond	Sub-26

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3147	Sub-34	3，4-diClPh	SO2	Single bond	Sub-27
2-3148	Sub-34	3，4-diClPh	SO2	Single bond	Sub-28
						2-3149	Sub-34	3，4-diClPh	SO2	Single bond	Sub-29
2-3150	Sub-34	3，4-diClPh	SO2	Single bond	Sub-30
						2-3151	Sub-34	3，4-diClPh	SO2	Single bond	Sub-31
2-3152	Sub-34	3，4-diClPh	SO2	Single bond	Sub-32
						2-3153	Sub-34	3，4-diClPh	SO2	Single bond	Sub-65
2-3154	Sub-34	3，4-diClPh	SO2	Single bond	Sub-66
						2-3155	Sub-34	3，4-diClPh	SO2	Single bond	Sub-67
2-3156	Sub-34	3，4-diClPh	SO2	Single bond	Sub-68
						2-3157	Sub-34	3，4-diClPh	SO2	Single bond	Sub-69
2-3158	Sub-34	3，4-diClPh	SO2	Single bond	Sub-70
						2-3159	Sub-34	3，4-diClPh	SO2	Single bond	Sub-71
2-3160	Sub-34	3，4-diClPh	SO2	Single bond	Sub-72
						2-3161	Sub-34	3，4-diClPh	SO2	Single bond	Sub-73
2-3162	Sub-34	3，4-dClPh	SO2	Single bond	Sub-74
						2-3163	Sub-34	3，4-diClPh	SO2	Single bond	Sub-75
2-3164	Sub-34	3，4-diClPh	SO2	Single bond	Sub-76
						2-3165	Sub-34	3，4-diClPh	SO2	Single bond	Sub-77
2-3166	Sub-34	3，4-diClPh	SO2	Single bond	Sub-78
						2-3167	Sub-34	3，4-diClPh	SO2	Single bond	Sub-79
2-3168	Sub-34	3，4-diClPh	SO2	Single bond	Sub-80
						2-3169	Sub-35	3，4-diClPh	SO2	Single bond	Sub-1
2-3170	Sub-35	3，4-diClPh	SO2	Single bond	Sub-2
						2-3171	Sub-35	3，4-diClPh	SO2	Single bond	Sub-3
2-3172	Sub-35	3，4-diClPh	SO2	Single bond	Sub-4

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3173	Sub-35	3，4-diClPh	SO2	Single bond	Sub-5
2-3174	Sub-35	3，4-diClPh	SO2	Single bond	Sub-6
						2-3175	Sub-35	3，4-diClPh	SO2	Single bond	Sub-7
2-3176	Sub-35	3，4-diClPh	SO2	Single bond	Sub-8
						2-3177	Sub-35	3，4-diClPh	SO2	Single bond	Sub-9
2-3178	Sub-35	3，4-diClPh	SO2	Single bond	Sub-10
						2-3179	Sub-35	3，4-diClPh	SO2	Single bond	Sub-11
2-3180	Sub-35	3，4-diClPh	SO2	Single bond	Sub-12
						2-3181	Sub-35	3，4-diClPh	SO2	Single bond	Sub-13
2-3182	Sub-35	3，4-diClPh	SO2	Single bond	Sub-14
						2-3183	Sub-35	3，4-diClPh	SO2	Single bond	Sub-15
2-3184	Sub-35	3，4-diClPh	SO2	Single bond	Sub-16
						2-3185	Sub-35	3，4-diClPh	SO2	Single bond	Sub-17
2-3186	Sub-35	3，4-diClPh	SO2	Single bond	Sub-18
						2-3187	Sub-35	3，4-diClPh	SO2	Single bond	Sub-19
2-3188	Sub-35	3，4-diClPh	SO2	Single bond	Sub-20
						2-3189	Sub-35	3，4-diClPh	SO2	Single bond	Sub-21
2-3190	Sub-35	3，4-diClPh	SO2	Single bond	Sub-22
						2-3191	Sub-35	3，4-diClPh	SO2	Single bond	Sub-23
2-3192	Sub-35	3，4-diClPh	SO2	Single bond	Sub-24
						2-3193	Sub-35	3，4-diClPh	SO2	Single bond	Sub-25
2-3194	Sub-35	3，4-diClPh	SO2	Single bond	Sub-26
						2-3195	Sub-35	3，4-diClPh	SO2	Single bond	Sub-27
2-3196	Sub-35	3，4-diClPh	SO2	Single bond	Sub-28
						2-3197	Sub-35	3，4-diClPh	SO2	Single bond	Sub-29
2-3198	Sub-35	3，4-diClPh	SO2	Single bond	Sub-30

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3199	Sub-35	3，4-diClPh	SO2	Single bond	Sub-31
2-3200	Sub-35	3，4-diClPh	SO2	Single bond	Sub-32
						2-3201	Sub-35	3，4-diClPh	SO2	Single bond	Sub-65
2-3202	Sub-35	3，4-diClPh	SO2	Single bond	Sub-66
						2-3203	Sub-35	3，4-diClPh	SO2	Single bond	Sub-67
2-3204	Sub-35	3，4-diClPh	SO2	Single bond	Sub-68
						2-3205	Sub-35	3，4-diClPh	SO2	Single bond	Sub-69
2-3206	Sub-35	3，4-diClPh	SO2	Single bond	Sub-70
						2-3207	Sub-35	3，4-diClPh	SO2	Single bond	Sub-71
2-3208	Sub-35	3，4-diClPh	SO2	Single bond	Sub-72
						2-3209	Sub-35	3，4-diClPh	SO2	Single bond	Sub-73
2-3210	Sub-35	3，4-diClPh	SO2	Single bond	Sub-74
						2-3211	Sub-35	3，4-diClPh	SO2	Single bond	Sub-75
2-3212	Sub-35	3，4-diClPh	SO2	Single bond	Sub-76
						2-3213	Sub-35	3，4-diClPh	SO2	Single bond	Sub-77
2-3214	Sub-35	3，4-diClPh	SO2	Single bond	Sub-78
						2-3215	Sub-35	3，4-diClPh	SO2	Single bond	Sub-79
2-3216	Sub-35	3，4-diClPh	SO2	Single bond	Sub-80
						2-3217	Sub-36	3，4-diClPh	SO2	Single bond	Sub-1
2-3218	Sub-36	3，4-diClPh	SO2	Single bond	Sub-2
						2-3219	Sub-36	3，4-diClPh	SO2	Single bond	Sub-3
2-3220	Sub-36	3，4-diClPh	SO2	Single bond	Sub-4
						2-3221	Sub-36	3，4-diClPh	SO2	Single bond	Sub-5
2-3222	Sub-36	3，4-diClPh	SO2	Single bond	Sub-6
						2-3223	Sub-36	3，4-diClPh	SO2	Single bond	Sub-7
2-3224	Sub-36	3，4-diClPh	SO2	Single bond	Sub-8

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3225	Sub-36	3，4-diClPh	SO2	Single bond	Sub-9
2-3226	Sub-36	3，4-diClPh	SO2	Single bond	Sub-10
						2-3227	Sub-36	3，4-diClPh	SO2	Single bond	Sub-11
2-3228	Sub-36	3，4-diClPh	SO2	Single bond	Sub-12
						2-3229	Sub-36	3，4-diClPh	SO2	Single bond	Sub-13
2-3230	Sub-36	3，4-diClPh	SO2	Single bond	Sub-14
						2-3231	Sub-36	3，4-diClPh	SO2	Single bond	Sub-15
2-3232	Sub-36	3，4-diClPh	SO2	Single bond	Sub-16
						2-3233	Sub-36	3，4-diClPh	SO2	Single bond	Sub-17
2-3234	Sub-36	3，4-diClPh	SO2	Single bond	Sub-18
						2-3235	Sub-36	3，4-diClPh	SO2	Single bond	Sub-19
2-3236	Sub-36	3，4-diClPh	SO2	Single bond	Sub-20
						2-3237	Sub-36	3，4-diClPh	SO2	Single bond	Sub-21
2-3238	Sub-36	3，4-diClPh	SO2	Single bond	Sub-22
						2-3239	Sub-36	3，4-diClPh	SO2	Single bond	Sub-23
2-3240	Sub-36	3，4-diClPh	SO2	Single bond	Sub-24
						2-3241	Sub-36	3，4-diClPh	SO2	Single bond	Sub-25
2-3242	Sub-36	3，4-diClPh	SO2	Single bond	Sub-26
						2-3243	Sub-36	3，4-diClPh	SO2	Single bond	Sub-27
2-3244	Sub-36	3，4-diClPh	SO2	Single bond	Sub-28
						2-3245	Sub-36	3，4-diClPh	SO2	Single bond	Sub-29
2-3246	Sub-36	3，4-diClPh	SO2	Single bond	Sub-30
						2-3247	Sub-36	3，4-diClPh	SO2	Single bond	Sub-31
2-3248	Sub-36	3，4-diClPh	SO2	Single bond	Sub-32
						2-3249	Sub-36	3，4-diClPh	SO2	Single bond	Sub-65
2-3250	Sub-36	3，4-diClPh	SO2	Single bond	Sub-66

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3251	Sub-36	3，4-diClPh	SO2	Single bond	Sub-67
2-3252	Sub-36	3，4-diClPh	SO2	Single bond	Sub-68
						2-3253	Sub-36	3，4-diClPh	SO2	Single bond	Sub-69
2-3254	Sub-36	3，4-diClPh	SO2	Single bond	Sub-70
						2-3255	Sub-36	3，4-diClPh	SO2	Single bond	Sub-71
2-3256	Sub-36	3，4-diClPh	SO2	Single bond	Sub-72
						2-3257	Sub-36	3，4-diClPh	SO2	Single bond	Sub-73
2-3258	Sub-36	3，4-diClPh	SO2	Single bond	Sub-74
						2-3259	Sub-36	3，4-diClPh	SO2	Single bond	Sub-75
2-3260	Sub-36	3，4-diClPh	SO2	Single bond	Sub-76
						2-3261	Sub-36	3，4-diClPh	SO2	Single bond	Sub-77
2-3262	Sub-36	3，4-diClPh	SO2	Single bond	Sub-78
						2-3263	Sub-36	3，4-diClPh	SO2	Single bond	Sub-79
2-3264	Sub-36	3，4-diClPh	SO2	Single bond	Sub-80
						2-3265	Sub-37	3，4-diClPh	SO2	Single bond	Sub-1
2-3266	Sub-37	3，4-diClPh	SO2	Single bond	Sub-2
						2-3267	Sub-37	3，4-diClPh	SO2	Single bond	Sub-3
2-3268	Sub-37	3，4-diClPh	SO2	Single bond	Sub-4
						2-3269	Sub-37	3，4-diClPh	SO2	Single bond	Sub-5
2-3270	Sub-37	3，4-diClPh	SO2	Single bond	Sub-6
						2-3271	Sub-37	3，4-diClPh	SO2	Single bond	Sub-7
2-3272	Sub-37	3，4-diClPh	SO2	Single bond	Sub-8
						2-3273	Sub-37	3，4-diClPh	SO2	Single bond	Sub-9
2-3274	Sub-37	3，4-diClPh	SO2	Single bond	Sub-10
						2-3275	Sub-37	3，4-diClPh	SO2	Single bond	Sub-11
2-3276	Sub-37	3，4-diClPh	SO2	Single bond	Sub-12

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3277	Sub-37	3，4-diClPh	SO2	Single bond	Sub-13
2-3278	Sub-37	3，4-diClPh	SO2	Single bond	Sub-14
						2-3279	Sub-37	3，4-diClPh	SO2	Single bond	Sub-15
2-3280	Sub-37	3，4-diClPh	SO2	Single bond	Sub-16
						2-3281	Sub-37	3，4-diClPh	SO2	Single bond	Sub-17
2-3282	Sub-37	3，4-diClPh	SO2	Single bond	Sub-18
						2-3283	Sub-37	3，4-diClPh	SO2	Single bond	Sub-19
2-3284	Sub-37	3，4-diClPh	SO2	Single bond	Sub-20
						2-3285	Sub-37	3，4-diClPh	SO2	Single bond	Sub-21
2-3286	Sub-37	3，4-diClPh	SO2	Single bond	Sub-22
						2-3287	Sub-37	3，4-diClPh	SO2	Single bond	Sub-23
2-3288	Sub-37	3，4-diClPh	SO2	Single bond	Sub-24
						2-3289	Sub-37	3，4-diClPh	SO2	Single bond	Sub-25
2-3290	Sub-37	3，4-diClPh	SO2	Single bond	Sub-26
						2-3291	Sub-37	3，4-diClPh	SO2	Single bond	Sub-27
2-3292	Sub-37	3，4-diClPh	SO2	Single bond	Sub-28
						2-3293	Sub-37	3，4-diClPh	SO2	Single bond	Sub-29
2-3294	Sub-37	3，4-diClPh	SO2	Single bond	Sub-30
						2-3295	Sub-37	3，4-diClPh	SO2	Single bond	Sub-31
2-3296	Sub-37	3，4-diClPh	SO2	Single bond	Sub-32
						2-3297	Sub-37	3，4-diClPh	SO2	Single bond	Sub-65
2-3298	Sub-37	3，4-diClPh	SO2	Single bond	Sub-66
						2-3299	Sub-37	3，4-diClPh	SO2	Single bond	Sub-67
2-3300	Sub-37	3，4-diClPh	SO2	Single bond	Sub-68
						2-3301	Sub-37	3，4-diClPh	SO2	Single bond	Sub-69
2-3302	Sub-37	3，4-diClPh	SO2	Single bond	Sub-70

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3303	Sub-37	3，4-diClPh	SO2	Single bond	Sub-71
2-3304	Sub-37	3，4-diClPh	SO2	Single bond	Sub-72
						2-3305	Sub-37	3，4-diClPh	SO2	Single bond	Sub-73
2-3306	Sub-37	3，4-diClPh	SO2	Single bond	Sub-74
						2-3307	Sub-37	3，4-diClPh	SO2	Single bond	Sub-75
2-3308	Sub-37	3，4-diClPh	SO2	Single bond	Sub-76
						2-3309	Sub-37	3，4-diClPh	SO2	Single bond	Sub-77
2-3310	Sub-37	3，4-diClPh	SO2	Single bond	Sub-78
						2-3311	Sub-37	3，4-diClPh	SO2	Single bond	Sub-79
2-3312	Sub-37	3，4-diClPh	SO2	Single bond	Sub-80
						2-3313	Sub-38	3，4-diClPh	SO2	Single bond	Sub-1
2-3314	Sub-38	3，4-diClPh	SO2	Single bond	Sub-2
						2-3315	Sub-38	3，4-diClPh	SO2	Single bond	Sub-3
2-3316	Sub-38	3，4-diClPh	SO2	Single bond	Sub-4
						2-3317	Sub-38	3，4-diClPh	SO2	Single bond	Sub-5
2-3318	Sub-38	3，4-diClPh	SO2	Single bond	Sub-6
						2-3319	Sub-38	3，4-diClPh	SO2	Single bond	Sub-7
2-3320	Sub-38	3，4-diClPh	SO2	Single bond	Sub-8
						2-3321	Sub-38	3，4-diClPh	SO2	Single bond	Sub-9
2-3322	Sub-38	3，4-diClPh	SO2	Single bond	Sub-10
						2-3323	Sub-38	3，4-diClPh	SO2	Single bond	Sub-11
2-3324	Sub-38	3，4-diClPh	SO2	Single bond	Sub-12
						2-3325	Sub-38	3，4-diClPh	SO2	Single bond	Sub-13
2-3326	Sub-38	3，4-diClPh	SO2	Single bond	Sub-14
						2-3327	Sub-38	3，4-diClPh	SO2	Single bond	Sub-15
2-3328	Sub-38	3，4-diClPh	SO2	Single bond	Sub-16

Table 2(cont.)

Chemical combinationArticle (A) Serial number	R1	R2	A	B	Z
						2-3329	Sub-38	3，4-diClPh	SO2	Single bond	Sub-17
2-3330	Sub-38	3，4-diClPh	SO2	Single bond	Sub-18
						2-3331	Sub-38	3，4-diClPh	SO2	Single bond	Sub-19
2-3332	Sub-38	3，4-diClPh	SO2	Single bond	Sub-20
						2-3333	Sub-38	3，4-diClPh	SO2	Single bond	Sub-21
2-3334	Sub-38	3，4-diClPh	SO2	Single bond	Sub-22
						2-3335	Sub-38	3，4-diClPh	SO2	Single bond	Sub-23
2-3336	Sub-38	3，4-diClPh	SO2	Single bond	Sub-24
						2-3337	Sub-38	3，4-diClPh	SO2	Single bond	Sub-25
2-3338	Sub-38	3，4-diClPh	SO2	Single bond	Sub-26
						2-3339	Sub-38	3，4-diClPh	SO2	Single bond	Sub-27
2-3340	Sub-38	3，4-diClPh	SO2	Single bond	Sub-28
						2-3341	Sub-38	3，4-diClPh	SO2	Single bond	Sub-29
2-3342	Sub-38	3，4-diClPh	SO2	Single bond	Sub-30
						2-3343	Sub-38	3，4-diClPh	SO2	Single bond	Sub-31
2-3344	Sub-38	3，4-diClPh	SO2	Single bond	Sub-32
						2-3345	Sub-38	3，4-diClPh	SO2	Single bond	Sub-65
2-3346	Sub-38	3，4-diClPh	SO2	Single bond	Sub-66
						2-3347	Sub-38	3，4-diClPh	SO2	Single bond	Sub-67
2-3348	Sub-38	3，4-diClPh	SO2	Single bond	Sub-68
						2-3349	Sub-38	3，4-diClPh	SO2	Single bond	Sub-69
2-3350	Sub-38	3，4-diClPh	SO2	Single bond	Sub-70
						2-3351	Sub-38	3，4-diClPh	SO2	Single bond	Sub-71
2-3352	Sub-38	3，4-diClPh	SO2	Single bond	Sub-72
						2-3353	Sub-38	3，4-diClPh	SO2	Single bond	Sub-73
2-3354	Sub-38	3，4-diClPh	SO2	Single bond	Sub-74

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3355	Sub-38	3，4-diClPh	SO2	Single bond	Sub-75
2-3356	Sub-38	3，4-diClPh	SO2	Single bond	Sub-76
						2-3357	Sub-38	3，4-diClPh	SO2	Single bond	Sub-77
2-3358	Sub-38	3，4-diClPh	SO2	Single bond	Sub-78
						2-3359	Sub-38	3，4-diClPh	SO2	Single bond	Sub-79
2-3360	Sub-38	3，4-diClPh	SO2	Single bond	Sub-80
						2-3361	Sub-39	3，4-diClPh	SO2	Single bond	Sub-1
2-3362	Sub-39	3，4-diClPh	SO2	Single bond	Sub-2
						2-3363	Sub-39	3，4-diClPh	SO2	Single bond	Sub-3
2-3364	Sub-39	3，4-diClPh	SO2	Single bond	Sub-4
						2-3365	Sub-39	3，4-diClPh	SO2	Single bond	Sub-5
2-3366	Sub-39	3，4-diClPh	SO2	Single bond	Sub-6
						2-3367	Sub-39	3，4-diClPh	SO2	Single bond	Sub-7
2-3368	Sub-39	3，4-diClPh	SO2	Single bond	Sub-8
						2-3369	Sub-39	3，4-diClPh	SO2	Single bond	Sub-9
2-3370	Sub-39	3，4-diClPh	SO2	Single bond	Sub-10
						2-3371	Sub-39	3，4-diClPh	SO2	Single bond	Sub-11
2-3372	Sub-39	3，4-diClPh	SO2	Single bond	Sub-12
						2-3373	Sub-39	3，4-diClPh	SO2	Single bond	Sub-13
2-3374	Sub-39	3，4-diClPh	SO2	Single bond	Sub-14
						2-3375	Sub-39	3，4-diClPh	SO2	Single bond	Sub-15
2-3376	Sub-39	3，4-diClPh	SO2	Single bond	Sub-16
						2-3377	Sub-39	3，4-diClPh	SO2	Single bond	Sub-17
2-3378	Sub-39	3，4-diClPh	SO2	Single bond	Sub-18
						2-3379	Sub-39	3，4-diClPh	SO2	Single bond	Sub-19
2-3380	Sub-39	3，4-diClPh	SO2	Single bond	Sub-20

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3381	Sub-39	3，4-diClPh	SO2	Single bond	Sub-21
2-3382	Sub-39	3，4-diClPh	SO2	Single bond	Sub-22
						2-3383	Sub-39	3，4-diClPh	SO2	Single bond	Sub-23
2-3384	Sub-39	3，4-diClPh	SO2	Single bond	Sub-24
						2-3385	Sub-39	3，4-diClPh	SO2	Single bond	Sub-25
2-3386	Sub-39	3，4-diClPh	SO2	Single bond	Sub-26
						2-3387	Sub-39	3，4-diClPh	SO2	Single bond	Sub-27
2-3388	Sub-39	3，4-diClPh	SO2	Single bond	Sub-28
						2-3389	Sub-39	3，4-diClPh	SO2	Single bond	Sub-29
2-3390	Sub-39	3，4-diClPh	SO2	Single bond	Sub-30
						2-3391	Sub-39	3，4-diClPh	SO2	Single bond	Sub-31
2-3392	Sub-39	3，4-diClPh	SO2	Single bond	Sub-32
						2-3393	Sub-39	3，4-diClPh	SO2	Single bond	Sub-65
2-3394	Sub-39	3，4-diClPh	SO2	Single bond	Sub-66
						2-3395	Sub-39	3，4-diClPh	SO2	Single bond	Sub-67
2-3396	Sub-39	3，4-diClPh	SO2	Single bond	Sub-68
						2-3397	Sub-39	3，4-diClPh	SO2	Single bond	Sub-69
2-3398	Sub-39	3，4-diClPh	SO2	Single bond	Sub-70
						2-3399	Sub-39	3，4-diClPh	SO2	Single bond	Sub-71
2-3400	Sub-39	3，4-diClPh	SO2	Single bond	Sub-72
						2-3401	Sub-39	3，4-diClPh	SO2	Single bond	Sub-73
2-3402	Sub-39	3，4-diClPh	SO2	Single bond	Sub-74
						2-3403	Sub-39	3，4-diClPh	SO2	Single bond	Sub-75
2-3404	Sub-39	3，4-diClPh	SO2	Single bond	Sub-76
						2-3405	Sub-39	3，4-diClPh	SO2	Single bond	Sub-77
2-3406	Sub-39	3，4-diClPh	SO2	Single bond	Sub-78

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3407	Sub-39	3，4-diClPh	SO2	Single bond	Sub-79
2-3408	Sub-39	3，4-diClPh	SO2	Single bond	Sub-80
						2-3409	Sub-40	3，4-diClPh	SO2	Single bond	Sub-1
2-3410	Sub-40	3，4-diClPh	SO2	Single bond	Sub-2
						2-3411	Sub-40	3，4-diClPh	SO2	Single bond	Sub-3
2-3412	Sub-40	3，4-diClPh	SO2	Single bond	Sub-4
						2-3413	Sub-40	3，4-diClPh	SO2	Single bond	Sub-5
2-3414	Sub-40	3，4-diClPh	SO2	Single bond	Sub-6
						2-3415	Sub-40	3，4-diClPh	SO2	Single bond	Sub-7
2-3416	Sub-40	3，4-diClPh	SO2	Single bond	Sub-8
						2-3417	Sub-40	3，4-diClPh	SO2	Single bond	Sub-9
2-3418	Sub-40	3，4-diClPh	SO2	Single bond	Sub-10
						2-3419	Sub-40	3，4-diClPh	SO2	Single bond	Sub-11
2-3420	Sub-40	3，4-diClPh	SO2	Single bond	Sub-12
						2-3421	Sub-40	3，4-diClPh	SO2	Single bond	Sub-13
2-3422	Sub-40	3，4-diClPh	SO2	Single bond	Sub-14
						2-3423	Sub-40	3，4-diClPh	SO2	Single bond	Sub-15
2-3424	Sub-40	3，4-diClPh	SO2	Single bond	Sub-16
						2-3425	Sub-40	3，4-diClPh	SO2	Single bond	Sub-17
2-3426	Sub-40	3，4-diClPh	SO2	Single bond	Sub-18
						2-3427	Sub-40	3，4-diClPh	SO2	Single bond	Sub-19
2-3428	Sub-40	3，4-diClPh	SO2	Single bond	Sub-20
						2-3429	Sub-40	3，4-diClPh	SO2	Single bond	Sub-21
2-3430	Sub-40	3，4-diClPh	SO2	Single bond	Sub-22
						2-3431	Sub-40	3，4-diClPh	SO2	Single bond	Sub-23
2-3432	Sub-40	3，4-diClPh	SO2	Single bond	Sub-24

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3433	Sub-40	3，4-diClPh	SO2	Single bond	Sub-25
2-3434	Sub-40	3，4-diClPh	SO2	Single bond	Sub-26
						2-3435	Sub-40	3，4-diClPh	SO2	Single bond	Sub-27
2-3436	Sub-40	3，4-diClPh	SO2	Single bond	Sub-28
						2-3437 Sub-40	3，4-diClPh	SO2	Sin	le bond	Sub-29
2-3438	Sub-40	3，4-diClPh	SO2	Single bond	Sub-30
						2-3439	Sub-40	3，4-diClPh	SO2	Single bond	Sub-31
2-3440	Sub-40	3，4-diClPh	SO2	Single bond	Sub-32
						2-3441	Sub-40	3，4-diClPh	SO2	Single bond	Sub-65
2-3442	Sub-40	3，4-diClPh	SO2	Single bond	Sub-66
						2-3443	Sub-40	3，4-diClPh	SO2	Single bond	Sub-67
2-3444	Sub-40	3，4-diClPh	SO2	Single bond	Sub-68
						2-3445	Sub-40	3，4-diClPh	SO2	Single bond	Sub-69
2-3446	Sub-40	3，4-diClPh	SO2	Single bond	Sub-70
						2-3447	Sub-40	3，4-diClPh	SO2	Single bond	Sub-71
2-3448	Sub-40	3，4-diClPh	SO2	Single bond	Sub-72
						2-3449	Sub-40	3，4-diClPh	SO2	Single bond	Sub-73
2-3450	Sub-40	3，4-diClPh	SO2	Single bond	Sub-74
						2-3451	Sub-40	3，4-diClPh	SO2	Single bond	Sub-75
2-3452	Sub-40	3，4-diClPh	SO2	Single bond	Sub-76
						2-3453	Sub-40	3，4-diClPh	SO2	Single bond	Sub-77
2-3454	Sub-40	3，4-diClPh	SO2	Single bond	Sub-78
						2-3455	Sub-40	3，4-diClPh	SO2	Single bond	Sub-79
2-3456	Sub-40	3，4-diClPh	SO2	Single bond	Sub-80
						2-3457	Sub-41	3，4-diClPh	SO2	Single bond	Sub-1
2-3458	Sub-41	3，4-diClPh	SO2	Single bond	Sub-2

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3459	Sub-41	3，4-diClPh	SO2	Single bond	Sub-3
2-3460	Sub-41	3，4-diClPh	SO2	Single bond	Sub-4
						2-3461	Sub-41	3，4-diClPh	SO2	Single bond	Sub-5
2-3462	Sub-41	3，4-diClPh	SO2	Single bond	Sub-6
						2-3463	Sub-41	3，4-diClPh	SO2	Single bond	Sub-7
2-3464	Sub-41	3，4-diClPh	SO2	Single bond	Sub-8
						2-3465	Sub-41	3，4-diClPh	SO2	Single bond	Sub-9
2-3466	Sub-41	3，4-diClPh	SO2	Single bond	Sub-10
						2-3467	Sub-41	3，4-diClPh	SO2	Single bond	Sub-11
2-3468	Sub-41	3，4-diClPh	SO2	Single bond	Sub-12
						2-3469	Sub-41	3，4-diClPh	SO2	Single bond	Sub-13
2-3470	Sub-41	3，4-diClPh	SO2	Single bond	Sub-14
						2-3471	Sub-41	3，4-diClPh	SO2	Single bond	Sub-15
2-3472	Sub-41	3，4-diClPh	SO2	Single bond	Sub-16
						2-3473	Sub-41	3，4-diClPh	SO2	Single bond	Sub-17
2-3474	Sub-41	3，4-diClPh	SO2	Single bond	Sub-18
						2-3475	Sub-41	3，4-diClPh	SO2	Single bond	Sub-19
2-3476	Sub-41	3，4-diClPh	SO2	Single bond	Sub-20
						2-3477	Sub-41	3，4-diClPh	SO2	Single bond	Sub-21
2-3478	Sub-41	3，4-diClPh	SO2	Single bond	Sub-22
						2-3479	Sub-41	3，4-diClPh	SO2	Single bond	Sub-23
2-3480	Sub-41	3，4-diClPh	SO2	Single bond	Sub-24
						2-3481	Sub-41	3，4-diClPh	SO2	Single bond	Sub-25
2-3482	Sub-41	3，4-diClPh	SO2	Single bond	Sub-26
						2-3483	Sub-41	3，4-diClPh	SO2	Single bond	Sub-27
2-3484	Sub-41	3，4-diClPh	SO2	Single bond	Sub-28

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3485	Sub-41	3，4-diClPh	SO2	Single bond	Sub-29
2-3486	Sub-41	3，4-diClPh	SO2	Single bond	Sub-30
						2-3487	Sub-41	3，4-diClPh	SO2	Single bond	Sub-31
2-3488	Sub-41	3，4-diClPh	SO2	Single bond	Sub-32
						2-3489	Sub-41	3，4-diClPh	SO2	Single bond	Sub-65
2-3490	Sub-41	3，4-diClPh	SO2	Single bond	Sub-66
						2-3491	Sub-41	3，4-diClPh	SO2	Single bond	Sub-67
2-3492	Sub-41	3，4-diClPh	SO2	Single bond	Sub-68
						2-3493	Sub-41	3，4-diClPh	SO2	Single bond	Sub-69
2-3494	Sub-41	3，4-diClPh	SO2	Single bond	Sub-70
						2-3495	Sub-41	3，4-diClPh	SO2	Single bond	Sub-71
2-3496	Sub-41	3，4-diClPh	SO2	Single bond	Sub-72
						2-3497	Sub-41	3，4-diClPh	SO2	Single bond	Sub-73
2-3498	Sub-41	3，4-diClPh	SO2	Single bond	Sub-74
						2-3499	Sub-41	3，4-diClPh	SO2	Single bond	Sub-75
2-3500	Sub-41	3，4-diClPh	SO2	Single bond	Sub-76
						2-3501	Sub-41	3，4-diClPh	SO2	Single bond	Sub-77
2-3502	Sub-41	3，4-diClPh	SO2	Single bond	Sub-78
						2-3503	Sub-41	3，4-diClPh	SO2	Single bond	Sub-79
2-3504	Sub-41	3，4-diClPh	SO2	Single bond	Sub-80
						2-3505	Sub-42	3，4-diClPh	SO2	Single bond	Sub-1
2-3506	Sub-42	3，4-diClPh	SO2	Single bond	Sub-2
						2-3507	Sub-42	3，4-diClPh	SO2	Single bond	Sub-3
2-3508	Sub-42	3，4-diClPh	SO2	Single bond	Sub-4
						2-3509	Sub-42	3，4-diClPh	SO2	Single bond	Sub-5
2-3510	Sub-42	3，4-diClPh	SO2	Single bond	Sub-6

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3511	Sub-42	3，4-diClPh	SO2	Single bond	Sub-7
2-3512	Sub-42	3，4-diClPh	SO2	Single bond	Sub-8
						2-3513	Sub-42	3，4-diClPh	SO2	Single bond	Sub-9
2-3514	Sub-42	3，4-diClPh	SO2	Single bond	Sub-10
						2-3515	Sub-42	3，4-diClPh	SO2	Single bond	Sub-11
2-3516	Sub-42	3，4-diClPh	SO2	Single bond	Sub-12
						2-3517	Sub-42	3，4-diClPh	SO2	Single bond	Sub-13
2-3518	Sub-42	3，4-diClPh	SO2	Single bond	Sub-14
						2-3519	Sub-42	3，4-diClPh	SO2	SheetKey with a key body	Sub-15
2-3520	Sub-42	3，4-diClPh	SO2	Single bond	Sub-16
						2-3521	Sub-42	3，4-diClPh	SO2	Single bond	Sub-17
2-3522	Sub-42	3，4-diClPh	SO2	Single bond	Sub-18
						2-3523	Sub-42	3，4-diClPh	SO2	Single bond	Sub-19
2-3524	Sub-42	3，4-diClPh	SO2	Single bond	Sub-20
						2-3525	Sub-42	3，4-diClPh	SO2	Single bond	Sub-21
2-3526	Sub-42	3，4-diClPh	SO2	Single bond	Sub-22
						2-3527	Sub-42	3，4-diClPh	SO2	Single bond	Sub-23
2-3528	Sub-42	3，4-diClPh	SO2	Single bond	Sub-24
						2-3529	Sub-42	3，4-diClPh	SO2	Single bond	Sub-25
2-3530	Sub-42	3，4-diClPh	SO2	Single bond	Sub-26
						2-3531	Sub-42	3，4-diClPh	SO2	Single bond	Sub-27
2-3532	Sub-42	3，4-diClPh	SO2	Single bond	Sub-28
						2-3533	Sub-42	3，4-diClPh	SO2	Single bond	Sub-29
2-3534	Sub-42	3，4-diClPh	SO2	Single bond	Sub-30
						2-3535	Sub-42	3，4-diClPh	SO2	Single bond	Sub-31
2-3536	Sub-42	3，4-diClPh	SO2	Single bond	Sub-32

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3537	Sub-42	3，4-diClPh	SO2	Single bond	Sub-65
2-3538	Sub-42	3，4-diClPh	SO2	Single bond	Sub-66
						2-3539	Sub-42	3，4-diClPh	SO2	Single bond	Sub-67
2-3540	Sub-42	3，4-diClPh	SO2	Single bond	Sub-68
						2-3541	Sub-42	3，4-diClPh	SO2	Single bond	Sub-69
2-3542	Sub-42	3，4-diClPh	SO2	Single bond	Sub-70
						2-3543	Sub-42	3，4-diClPh	SO2	Single bond	Sub-71
2-3544	Sub-42	3，4-diClPh	SO2	Single bond	Sub-72
						2-3545	Sub-42	3，4-diClPh	SO2	Single bond	Sub-73
2-3546	Sub-42	3，4-diClPh	SO2	Single bond	Sub-74
						2-3547	Sub-42	3，4-diClPh	SO2	Single bond	Sub-75
2-3548	Sub-42	3，4-diClPh	SO2	Single bond	Sub-76
						2-3549	Sub-42	-，4-diClPh	SO2	Single bond	Sub-77
2-3550	Sub-42	3，4-diClPh	SO2	Single bond	Sub-78
						2-3551	Sub-42	3，4-diClPh	SO2	Single bond	Sub-79
2-3552	Sub-42	3，4-diClPh	SO2	Single bond	Sub-80
						2-3553	Sub-43	3，4-diClPh	SO2	Single bond	Sub-1
2-3554	Sub-43	3，4-diClPh	SO2	Single bond	Sub-2
						2-3555	Sub-43	3，4-diClPh	SO2	Single bond	Sub-3
2-3556	Sub-43	3，4-diClPh	SO2	Single bond	Sub-4
						2-3557	Sub-43	3，4-diClPh	SO2	Single bond	Sub-5
2-3558	Sub-43	3，4-diClPh	SO2	Single bond	Sub-6
						2-3559	Sub-43	3，4-diClPh	SO2	Single bond	Sub-7
2-3560	Sub-43	3，4-diClPh	SO2	Single bond	Sub-8
						2-3561	Sub-43	3，4-diClPh	SO2	Single bond	Sub-9
2-3562	Sub-43	3，4-diClPh	SO2	Single bond	Sub-10

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3563	Sub-43	3，4-diClPh	SO2	Single bond	Sub-11
2-3564	Sub-43	3，4-diClPh	SO2	Single bond	Sub-12
						2-3565	Sub-43	3，4-diClPh	SO2	Single bond	Sub-13
2-3566	Sub-43	3，4-diClPh	SO2	Single bond	Sub-14
						2-3567	Sub-43	3，4-diClPh	SO2	Single bond	Sub-15
2-3568	Sub-43	3，4-diClPh	SO2	Single bond	Sub-16
						2-3569	Sub-43	3，4-diClPh	SO2	Single bond	Sub-17
2-3570	Sub-43	3，4-diClPh	SO2	Single bond	Sub-18
						2-3571	Sub-43	3，4-diClPh	SO2	Single bond	Sub-19
2-3572	Sub-43	3，4-diClPh	SO2	Single bond	Sub-20
						2-3573	Sub-43	3，4-diClPh	SO2	Single bond	Sub-21
2-3574	Sub-43	3，4-diClPh	SO2	Single bond	Sub-22
						2-3575	Sub-43	3，4-diClPh	SO2	Single bond	Sub-23
2-3576	Sub-43	3，4-diClPh	SO2	Single bond	Sub-24
						2-3577	Sub-43	3，4-diClPh	SO2	Single bond	Sub-25
2-3578	Sub-43	3，4-diClPh	SO2	Single bond	Sub-26
						2-3579	Sub-43	3，4-diClPh	SO2	Single bond	Sub-27
2-3580	Sub-43	3，4-diClPh	SO2	Single bond	Sub-28
						2-3581	Sub-43	3，4-diClPh	SO2	Single bond	Sub-29
2-3582	Sub-43	3，4-diClPh	SO2	Single bond	Sub-30
						2-3583	Sub-43	3，4-diClPh	SO2	Single bond	Sub-31
2-3584	Sub-43	3，4-diClPh	SO2	Single bond	Sub-32
						2-3585	Sub-43	3，4-diClPh	SO2	Single bond	Sub-65
2-3586	Sub-43	3，4-diClPh	SO2	Single bond	Sub-66
						2-3587	Sub-43	3，4-diClPh	SO2	Single bond	Sub-67
2-3588	Sub-43	3，4-diClPh	SO2	Single bond	Sub-68

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3589	Sub-43	3，4-diC-Ph	SO2	Single bond	Sub-69
2-3590	Sub-43	3，4-diClPh	SO2	Single bond	Sub-70
						2-3591	Sub-43	3，4-diClPh	SO2	Single bond	Sub-71
2-3592	Sub-43	3，4-diClPh	SO2	Single bond	Sub-72
						2-3593	Sub-43	3，4-diClPh	SO2	Single bond	Sub-73
2-3594	Sub-43	3，4-diClPh	SO2	Single bond	Sub-74
						2-3595	Sub-43	3，4-diClPh	SO2	Single bond	Sub-75
2-3596	Sub-43	3，4-diClPh	SO2	Single bond	Sub-76
						2-3597	Sub-43	3，4-diClPh	SO2	Single bond	Sub-77
2-3598	Sub-43	3，4-diClPh	SO2	Single bond	Sub-78
						2-3599	Sub-43	3，4-diClPh	SO2	Single bond	Sub-79
2-3600	Sub-43	3，4-diClPh	SO2	Single bond	Sub-80
						2-3601	Sub-44	3，4-diClPh	SO2	Single bond	Sub-1
2-3602	Sub-44	3，4-diClPh	SO2	Single bond	Sub-2
						2-3603	Sub-44	3，4-diClPh	SO2	Single bond	Sub-3
2-3604	Sub-44	3，4-diClPh	SO2	Single bond	Sub-4
						2-3605	Sub-44	3，4-diClPh	SO2	Single bond	Sub-5
2-3606	Sub-44	3，4-diClPh	SO2	Single bond	Sub-6
						2-3607	Sub-44	3，4-diClPh	SO2	Single bond	Sub-7
2-3608	Sub-44	3，4-diClPh	SO2	Single bond	Sub-8
						2-3609	Sub-44	3，4-diClPh	SO2	Single bond	Sub-9
2-3610	Sub-44	3，4-diClPh	SO2	Single bond	Sub-10
						2-3611	Sub-44	3，4-diClPh	SO2	Single bond	Sub-11
2-3612	Sub-44	3，4-diClPh	SO2	Single bond	Sub-12
						2-3613	Sub-44	3，4-diClPh	SO2	Single bond	Sub-13
2-3614	Sub-44	3，4-diClPh	SO2	Single bond	Sub-14

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3615	Sub-44	3，4-diClPh	SO2	Single bond	Sub-15
2-3616	Sub-44	3，4-diClPh	SO2	Single bond	Sub-16
						2-3617	Sub-44	3，4-diClPh	SO2	Single bond	Sub-17
2-3618	Sub-44	3，4-diClPh	SO2	Single bond	Sub-18
						2-3619	Sub-44	3，4-diClPh	SO2	Single bond	Sub-19
2-3620	Sub-44	3，4-diClPh	SO2	Single bond	Sub-20
						2-3621	Sub-44	3，4-diClPh	SO2	Single bond	Sub-21
2-3622	Sub-44	3，4-diClPh	SO2	Single bond	Sub-22
						2-3623	Sub-44	3，4-diClPh	SO2	Single bond	Sub-23
2-3624	Sub-44	3，4-diClPh	SO2	Single bond	Sub-24
						2-3625	Sub-44	3，4-diClPh	SO2	Single bond	Sub-25
2-3626	Sub-44	3，4-diClPh	SO2	Single bond	Sub-26
						2-3627	Sub-44	3，4-diClPh	SO2	Single bond	Sub-27
2-3628	Sub-44	3，4-diClPh	SO2	Single bond	Sub-28
						2-3629	Sub-44	3，4-diClPh	SO2	Single bond	Sub-29
2-3630	Sub-44	3，4-diClPh	SO2	Single bond	Sub-30
						2-3631	Sub-44	3，4-diClPh	SO2	Single bond	Sub-31
2-3632	Sub-44	3，4-diClPh	SO2	Single bond	Sub-32
						2-3633	Sub-44	3，4-diClPh	SO2	Single bond	Sub-65
2-3634	Sub-44	3，4-diClPh	SO2	Single bond	Sub-66
						2-3635	Sub-44	3，4-diClPh	SO2	Single bond	Sub-67
2-3636	Sub-44	3，4-diClPh	SO2	Single bond	Sub-68
						2-3637	Sub-44	3，4-diClPh	SO2	Single bond	Sub-69
2-3638	Sub-44	3，4-diClPh	SO2	Single bond	Sub-70
						2-3639	Sub-44	3，4-diClPh	SO2	Single bond	Sub-71
2-3640	Sub-44	3，4-diClPh	SO2	Single bond	Sub-72

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3641	Sub-44	3，4-diClPh	SO2	Single bond	Sub-73
2-3642	Sub-44	3，4-diClPh	SO2	Single bond	Sub-74
						2-3643	Sub-44	3，4-diClPh	SO2	Single bond	Sub-75
2-3644	Sub-44	3，4-diClPh	SO2	Single bond	Sub-76
						2-3645	Sub-44	3，4-diClPh	SO2	Single bond	Sub-77
2-3646	Sub-44	3，4-diClPh	SO2	Single bond	Sub-78
						2-3647	Sub-44	3，4-diClPh	SO2	Single bond	Sub-79
2-3648	Sub-44	3，4-diClPh	SO2	Single bond	Sub-80
						2-3649	Sub-45	3，4-diClPh	SO2	Single bond	Sub-1
2-3650	Sub-45	3，4-diClPh	SO2	Single bond	Sub-2
						2-3651	Sub-45	3，4-diClPh	SO2	Single bond	Sub-3
2-3652	Sub-45	3，4-diClPh	SO2	Single bond	Sub-4
						2-3653	Sub-45	3，4-diClPh	SO2	Single bond	Sub-5
2-3654	Sub-45	3，4-diClPh	SO2	Single bond	Sub-6
						2-3655	Sub-45	3，4-diClPh	SO2	Single bond	Sub-7
2-3656	Sub-45	3，4-diClPh	SO2	Single bond	Sub-8
						2-3657	Sub-45	3，4-diClPh	SO2	Single bond	Sub-9
2-3658	Sub-45	3，4-diClPh	SO2	Single bond	Sub-10
						2-3659	Sub-45	3，4-diClPh	SO2	Single bond	Sub-11
2-3660	Sub-45	3，4-diClPh	SO2	Single bond	Sub-12
						2-3661	Sub-45	3，4-diClPh	SO2	Single bond	Sub-13
2-3662	Sub-45	3，4-diClPh	SO2	Single bond	Sub-14
						2-3663	Sub-45	3，4-diClPh	SO2	Single bond	Sub-15
2-3664	Sub-45	3，4-diClPh	SO2	Single bond	Sub-16
						2-3665	Sub-45	3，4-diClPh	SO2	Single bond	Sub-17
2-3666	Sub-45	3，4-diClPh	SO2	Single bond	Sub-18

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3667	Sub-45	3，4-diClPh	SO2	Single bond	Sub-19
2-3668	Sub-45	3，4-diClPh	SO2	Single bond	Sub-20
						2-3669	Sub-45	3，4-diClPh	SO2	Single bond	Sub-21
2-3670	Sub-45	3，4-diClPh	SO2	Single bond	Sub-22
						2-3671	Sub-45	3，4-diClPh	SO2	Single bond	Sub-23
2-3672	Sub-45	3，4-diClPh	SO2	Single bond	Sub-24
						2-3673	Sub-45	3，4-diClPh	SO2	Single bond	Sub-25
2-3674	Sub-45	3，4-diClPh	SO2	Single bond	Sub-26
						2-3675	Sub-45	3，4-diClPh	SO2	Single bond	Sub-27
2-3676	Sub-45	3，4-diClPh	SO2	Single bond	Sub-28
						2-3677	Sub-45	3，4-diClPh	SO2	Single bond	Sub-29
2-3678	Sub-45	3，4-diClPh	SO2	Single bond	Sub-30
						2-3679	Sub-45	3，4-diClPh	SO2	Single bond	Sub-31
2-3680	Sub-45	3，4-diClPh	SO2	Single bond	Sub-32
						2-3681	Sub-45	3，4-diClPh	SO2	Single bond	Sub-65
2-3682	Sub-45	3，4-diClPh	SO2	Single bond	Sub-66
						2-3683	Sub-45	3，4-diClPh	SO2	Single bond	Sub-67
2-3684	Sub-45	3，4-diClPh	SO2	Single bond	Sub-68
						2-3685	Sub-45	3，4-diClPh	SO2	Single bond	Sub-69
2-3686	Sub-45	3，4-diClPh	SO2	Single bond	Sub-70
						2-3687	Sub-45	3，4-diClPh	SO2	Single bond	Sub-71
2-3688	Sub-45	3，4-diClPh	SO2	Single bond	Sub-72
						2-3689	Sub-45	3，4-diClPh	SO2	Single bond	Sub-73
2-3690	Sub-45	3，4-diClPh	SO2	Single bond	Sub-74
						2-3691	Sub-45	3，4-diClPh	SO2	Single bond	Sub-75
2-3692	Sub-45	3，4-diClPh	SO2	Single bond	Sub-76

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3693	Sub-45	3，4-diClPh	SO2	Single bond	Sub-77
2-3694	Sub-45	3，4-diClPh	SO2	Single bond	Sub-78
						2-3695	Sub-45	3，4-diClPh	SO2	Single bond	Sub-79
2-3696	Sub-45	3，4-diClPh	SO2	Single bond	Sub-80
						2-3697	Sub-46	3，4-diClPh	SO2	Single bond	Sub-1
2-3698	Sub-46	3，4-diClPh	SO2	Single bond	Sub-2
						2-3699	Sub-46	3，4-diClPh	SO2	Single bond	Sub-3
2-3700	Sub-46	3，4-diClPh	SO2	Single bond	Sub-4
						2-3701	Sub-46	3，4-diClPh	SO2	Single bond	Sub-5
2-3702	Sub-46	3，4-diClPh	SO2	Single bond	Sub-6
						2-3703	Sub-46	3，4-diClPh	SO2	Single bond	Sub-7
2-3704	Sub-46	3，4-diClPh	SO2	Single bond	Sub-8
						2-3705	Sub-46	3，4-diClPh	SO2	Single bond	Sub-9
2-3706	Sub-46	3，4-diClPh	SO2	Single bond	Sub-10
						2-3707	Sub-46	3，4-diClPh	SO2	Single bond	Sub-11
2-3708	Sub-46	3，4-diClPh	SO2	Single bond	Sub-12
						2-3709	Sub-46	3，4-diClPh	SO2	Single bond	Sub-13
2-3710	Sub-46	3，4-diClPh	SO2	Single bond	Sub-14
						2-3711	Sub-46	3，4-diClPh	SO2	Single bond	Sub-15
2-3712	Sub-46	3，4-diClPh	SO2	Single bond	Sub-16
						2-3713	Sub-46	3，4-diClPh	SO2	Single bond	Sub-17
2-3714	Sub-46	3，4-diClPh	SO2	Single bond	Sub-18
						2-3715	Sub-46	3，4-diClPh	SO2	Single bond	Sub-19
2-3716	Sub-46	3，4-diClPh	SO2	Single bond	Sub-20
						2-3717	Sub-46	3，4-diClPh	SO2	Single bond	Sub-21
2-3718	Sub-46	3，4-diClPh	SO2	Single bond	Sub-22

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3719	Sub-46	3，4-diClPh	SO2	Single bond	Sub-23
2-3720	Sub-46	3，4-diClPh	SO2	Single bond	Sub-24
						2-3721	Sub-46	3，4-diClPh	SO2	Single bond	Sub-25
2-3722	Sub-46	3，4-diClPh	SO2	Single bond	Sub-26
						2-3723	Sub-46	3，4-diClPh	SO2	Single bond	Sub-27
2-3724	Sub-46	3，4-diClPh	SO2	Single bond	Sub-28
						2-3725	Sub-46	3，4-diClPh	SO2	Single bond	Sub-29
2-3726	Sub-46	3，4-diClPh	SO2	Single bond	Sub-30
						2-3727	Sub-46	3，4-diClPh	SO2	Single bond	Sub-31
2-3728	Sub-46	3，4-diClPh	SO2	Single bond	Sub-32
						2-3729	Sub-46	3，4-diClPh	SO2	Single bond	Sub-65
2-3730	Sub-46	3，4-diClPh	SO2	Single bond	Sub-66
						2-3731	Sub-46	3，4-diClPh	SO2	Single bond	Sub-67
2-3732	Sub-46	3，4-diClPh	SO2	Single bond	Sub-68
						2-3733	Sub-46	3，4-diClPh	SO2	Single bond	Sub-69
2-3734	Sub-46	3，4-diClPh	SO2	Single bond	Sub-70
						2-3735	Sub-46	3，4-diClPh	SO2	Single bond	Sub-71
2-3736	Sub-46	3，4-diClPh	SO2	Single bond	Sub-72
						2-3737	Sub-46	3，4-diClPh	SO2	Single bond	Sub-73
2-3738	Sub-46	3，4-diClPh	SO2	Single bond	Sub-74
						2-3739	Sub-46	3，4-diClPh	SO2	Single bond	Sub-75
2-3740	Sub-46	3，4-diClPh	SO2	Single bond	Sub-76
						2-3741	Sub-46	3，4-diClPh	SO2	Single bond	Sub-77
2-3742	Sub-46	3，4-diClPh	SO2	Single bond	Sub-78
						2-3743	Sub-46	3，4-diClPh	SO2	Single bond	Sub-79
2-3744	Sub-46	3，4-diClPh	SO2	Single bond	Sub-80

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3745	Sub-47	3，4-diClPh	SO2	Single bond	Sub-1
2-3746	Sub-47	3，4-diClPh	SO2	Single bond	Sub-2
						2-3747	Sub-47	3，4-diClPh	SO2	Single bond	Sub-3
2-3748	Sub-47	3，4-diClPh	SO2	Single bond	Sub-4
						2-3749	Sub-47	3，4-diClPh	SO2	Single bond	Sub-5
2-3750	Sub-47	3，4-diClPh	SO2	Single bond	Sub-6
						2-3751	Sub-47	3，4-diClPh	SO2	Single bond	Sub-7
2-3752	Sub-47	3，4-diClPh	SO2	Single bond	Sub-8
						2-3753	Sub-47	3，4-diClPh	SO2	Single bond	Sub-9
2-3754	Sub-47	3，4-diClPh	SO2	Single bond	Sub-10
						2-3755	Sub-47	3，4-diClPh	SO2	Single bond	Sub-11
2-3756	Sub-47	3，4-diClPh	SO2	Single bond	Sub-12
						2-3757	Sub-47	3，4-diClPh	SO2	Single bond	Sub-13
2-3758	Sub-47	3，4-diClPh	SO2	Single bond	Sub-14
						2-3759	Sub-47	3，4-diClPh	SO2	Single bond	Sub-15
2-3760	Sub-47	3，4-diClPh	SO2	Single bond	Sub-16
						2-3761	Sub-47	3，4-diClPh	SO2	Single bond	Sub-17
2-3762	Sub-47	3，4-diClPh	SO2	Single bond	Sub-18
						2-3763	Sub-47	3，4-diClPh	SO2	Single bond	Sub-19
2-3764	Sub-47	3，4-diClPh	SO2	Single bond	Sub-20
						2-3765	Sub-47	3，4-diClPh	SO2	Single bond	Sub-21
2-3766	Sub-47	3，4-diClPh	SO2	Single bond	Sub-22
						2-3767	Sub-47	3，4-diClPh	SO2	Single bond	Sub-23
2-3768	Sub-47	3，4-diClPh	SO2	Single bond	Sub-24
						2-3769	Sub-47	3，4-diClPh	SO2	Single bond	Sub-25
2-3770	Sub-47	3，4-diClPh	SO2	Single bond	Sub-26

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3771	Sub-47	3，4-diClPh	SO2	Single bond	Sub-27
2-3772	Sub-47	3，4-diClPh	SO2	Single bond	Sub-28
						2-3773	Sub-47	3，4-diClPh	SO2	Single bond	Sub-29
2-3774	Sub-47	3，4-diClPh	SO2	Single bond	Sub-30
						2-3775	Sub-47	3，4-diClPh	SO2	Single bond	Sub-31
2-3776	Sub-47	3，4-diClPh	SO2	Single bond	Sub-32
						2-3777	Sub-47	3，4-diClPh	SO2	Single bond	Sub-65
2-3778	Sub-47	3，4-diClPh	SO2	Single bond	Sub-66
						2-3779	Sub-47	3，4-diClPh	SO2	Single bond	Sub-67
2-3780	Sub-47	3，4-diClPh	SO2	Single bond	Sub-68
						2-3781	Sub-47	3，4-diClPh	SO2	Single bond	Sub-69
2-3782	Sub-47	3，4-diClPh	SO2	Single bond	Sub-7O
						2-3783	Sub-47	3，4-diClPh	SO2	Single bond	Sub-71
2-3784	Sub-47	3，4-diClPh	SO2	Single bond	Sub-72
						2-3785	Sub-47	3，4-diClPh	SO2	Single bond	Sub-73
2-3786	Sub-47	3，4-diClPh	SO2	Single bond	Sub-74
						2-3787	Sub-47	3，4-diClPh	SO2	Single bond	Sub-75
2-3788	Sub-47	3，4-diClPh	SO2	Single bond	Sub-76
						2-3789	Sub-47	3，4-diClPh	SO2	Single bond	Sub-77
2-3790	Sub-47	3，4-diClPh	SO2	Single bond	Sub-78
						2-3791	Sub-47	3，4-diClPh	SO2	Single bond	Sub-79
2-3792	Sub-47	3，4-diClPh	SO2	Single bond	Sub-80
						2-3793	Sub-81	3，4-diClPh	SO2	Single bond	Sub-1
2-3794	Sub-81	3，4-diClPh	SO2	Single bond	Sub-2
						2-3795	Sub-81	3，4-diClPh	SO2	Single bond	Sub-3
2-3796	Sub-81	3，4-diClPh	SO2	Single bond	Sub-4

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3797	Sub-81	3，4-diClPh	SO2	Single bond	Sub-5
2-3798	Sub-81	3，4-diClPh	SO2	Single bond	Sub-6
						2-3799	Sub-81	3，4-diClPh	SO2	Single bond	Sub-7
2-3800	Sub-81	3，4-diClPh	SO2	Single bond	Sub-8
						2-3801	Sub-81	3，4-diClPh	SO2	Single bond	Sub-9
2-3802	Sub-81	3，4-diClPh	SO2	Single bond	Sub-10
						2-3803	Sub-81	3，4-diClPh	SO2	Single bond	Sub-11
2-3804	Sub-81	3，4-diClPh	SO2	Single bond	Sub-12
						2-3805	Sub-81	3，4-diClPh	SO2	Single bond	Sub-13
2-3806	Sub-81	3，4-diClPh	SO2	Single bond	Sub-14
						2-3807	Sub-81	3，4-diClPh	SO2	Single bond	Sub-15
2-3808	Sub-81	3，4-diClPh	SO2	Single bond	Sub-16
						2-3809	Sub-81	3，4-diClPh	SO2	Single bond	Sub-17
2-3810	Sub-81	3，4-diClPh	SO2	Single bond	Sub-18
						2-3811	Sub-81	3，4-diClPh	SO2	Single bond	Sub-19
2-3812	Sub-81	3，4-diClPh	SO2	Single bond	Sub-20
						2-3813	Sub-81	3，4-diClPh	SO2	Single bond	Sub-21
2-3814	Sub-81	3，4-diClPh	SO2	Single bond	Sub-22
						2-3815	Sub-81	3，4-diClPh	SO2	Single bond	Sub-23
2-3816	Sub-81	3，4-diClPh	SO2	Single bond	Sub-24
						2-3817	Sub-81	3，4-diClPh	SO2	Single bond	Sub-25
2-3818	Sub-81	3，4-diClPh	SO2	Single bond	Sub-26
						2-3819	Sub-81	3，4-diClPh	SO2	Single bond	Sub-27
2-3820	Sub-81	3，4-diClPh	SO2	Single bond	Sub-28
						2-3821	Sub-81	3，4-diClPh	SO2	Single bond	Sub-29
2-3822	Sub-81	3，4-diClPh	SO2	Single bond	Sub-30

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3823	Sub-81	3，4-diClPh	SO2	Single bond	Sub-31
2-3824	Sub-81	3，4-diClPh	SO2	Single bond	Sub-32
						2-3825	Sub-81	3，4-diClPh	SO2	Single bond	Sub-65
2-3826	Sub-81	3，4-diClPh	SO2	Single bond	Sub-66
						2-3827	Sub-81	3，4-diClPh	SO2	Single bond	Sub-67
2-3828	Sub-81	3，4-diClPh	SO2	Single bond	Sub-68
						2-3829	Sub-81	3，4-diClPh	SO2	Single bond	Sub-69
2-3830	Sub-81	3，4-diClPh	SO2	Single bond	Sub-70
						2-3831	Sub-81	3，4-diClPh	SO2	Single bond	Sub-71
2-3832	Sub-81	3，4-diClPh	S02	Single bond	Sub-72
						2-3833	Sub-81	3，4-diClPh	SO2	Single bond	Sub-73
2-3834	Sub-81	3，4-diClPh	SO2	Single bond	Sub-74
						2-3835	Sub-81	3，4-diClPh	SO2	Single bond	Sub-75
2-3836	Sub-81	3，4-diClPh	SO2	Single bond	Sub-76
						2-3837	Sub-81	3，4-diClPh	SO2	Single bond	Sub-77
2-3838	Sub-81	3，4-diClPh	SO2	Single bond	Sub-78
						2-3839	Sub-81	3，4-diClPh	SO2	Single bond	Sub-79
2-3840	Sub-81	3，4-diClPh	SO2	Single bond	Sub-80
						2-3841	Sub-48	3，4-diClPh	SO2	Single bond	Sub-1
2-3842	Sub-48	3，4-diClPh	SO2	Single bond	Sub-2
						2-3843	Sub-48	3，4-diClPh	SO2	Single bond	Sub-3
2-3844	Sub-48	3，4-diClPh	SO2	Single bond	Sub-4
						2-3845	Sub-48	3，4-diClPh	SO2	Single bond	Sub-5
2-3846	Sub-48	3，4-diClPh	SO2	Single bond	Sub-6
						2-3847	Sub-48	3，4-diClPh	SO2	Single bond	Sub-7
2-3848	Sub-48	3，4-diClPh	SO2	Single bond	Sub-8

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3849	Sub-48	3，4-diClPh	SO2	Single bond	Sub-9
2-3850	Sub-48	3，4-diClPh	SO2	Single bond	Sub-10
						2-3851	Sub-48	3，4-diClPh	SO2	Single bond	Sub-11
2-3852	Sub-48	3，4-diClPh	SO2	Single bond	Sub-12
						2-3853	Sub-48	3，4-diClPh	SO2	Single bond	Sub-13
2-3854	Sub-48	3，4-diClPh	SO2	Single bond	Sub-14
						2-3855	Sub-48	3，4-diClPh	SO2	Single bond	Sub-15
2-3856	Sub-48	3，4-diClPh	SO2	Single bond	Sub-16
						2-3857	Sub-48	3，4-diClPh	SO2	Single bond	Sub-17
2-3858	Sub-48	3，4-diClPh	SO2	Single bond	Sub-18
						2-3859	Sub48	3，4-diClPh	SO2	Single bond	Sub-19
2-3860	Sub-48	3，4-diClPh	SO2	Single bond	Sub-20
						2-3861	Sub-48	3，4-diClPh	SO2	Single bond	Sub-21
2-3862	Sub-48	3，4-diClPh	SO2	Single bond	Sub-22
						2-3863	Sub-48	3，4-diClPh	SO2	Single bond	Sub-23
2-3864	Sub-48	3，4-diClPh	SO2	Single bond	Sub-24
						2-3865	Sub-48	3，4-diClPh	SO2	Single bond	Sub-25
2-3866	Sub-48	3，4-diClPh	SO2	Single bond	Sub-26
						2-3867	Sub-48	3，4-diClPh	SO2	Single bond	Sub-27
2-3868	Sub-48	3，4-diClPh	SO2	Single bond	Sub-28
						2-3869	Sub-48	3，4-diClPh	SO2	Single bond	Sub-29
2-3870	Sub-48	3，4-diClPh	SO2	Single bond	Sub-30
						2-3871	Sub-48	3，4-diClPh	SO2	Single bond	Sub-31
2-3872	Sub-48	3，4-diClPh	SO2	Single bond	Sub-32
						2-3873	Sub-48	3，4-diClPh	SO2	Single bond	Sub-S5
2-3874	Sub-48	3，4-diClPh	SO2	Single bond	Sub-66

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3875	Sub-48	3，4-diClPh	SO2	Single bond	Sub-67
2-3876	Sub-48	3，4-diClPh	SO2	Single bond	Sub-68
						2-3877	Sub-48	3，4-diClPh	SO2	Single bond	Sub-69
2-3878	Sub-48	3，4-diClPh	SO2	Single bond	Sub-70
						2-3879	Sub-48	3，4-diClPh	SO2	Single bond	Sub-71
2-3880	Sub-48	3，4-diClPh	SO2	Single bond	Sub-72
						2-3881	Sub-48	3，4-diClPh	SO2	Single bond	Sub-73
2-3882	Sub-48	3，4-diClPh	SO2	Single bond	Sub-74
						2-3883	Sub-48	3，4-diClPh	SO2	Single bond	Sub-75
2-3884	Sub-48	3，4-diClPh	SO2	Single bond	Sub-76
						2-3885	Sub-48	3，4-diClPh	SO2	Single bond	Sub-77
2-3886	Sub-48	3，4-diClPh	SO2	Single bond	Sub-78
						2-3887	Sub-48	3，4-diClPh	SO2	Single bond	Sub-79
2-3888	Sub-48	3，4-diClPh	SO2	Single bond	Sub-80
						2-3889	Sub-49	3，4-diClPh	SO2	Single bond	Sub-1
2-3890	Sub-49	3，4-diClPh	SO2	Single bond	Sub-2
						2-3891	Sub-49	3，4-diClPh	SO2	Single bond	Sub-3
2-3892	Sub-49	3，4-diClPh	SO2	Single bond	Sub-4
						2-3893	Sub-49	3，4-diClPh	SO2	Single bond	Sub-5
2-3894	Sub-49	3，4-diClPh	SO2	Single bond	Sub-6
						2-3895	Sub-49	3，4-diClPh	SO2	Single bond	Sub-7
2-3896	Sub-49	3，4-diClPh	SO2	Single bond	Sub-8
						2-3897	Sub-49	3，4-diClPh	SO2	Single bond	Sub-9
2-3898	Sub-49	3，4-diClPh	SO2	Single bond	Sub-10
						2-3899	Sub-49	3，4-diClPh	SO2	Single bond	Sub-11
2-3900	Sub-49	3，4-diClPh	SO2	Single bond	Sub-12

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3901	Sub-49	3，4-diClPh	SO2	Single bond	Sub-13
2-3902	Sub-49	3，4-diClPh	SO2	Single bond	Sub-14
						2-3903	Sub-49	3，4-diClPh	SO2	Single bond	Sub-15
2-3904	Sub-49	3，4-diClPh	SO2	Single bond	Sub-16
						2-3905	Sub-49	3，4-diClPh	SO2	Single bond	Sub-17
2-3906	Sub-49	3，4-diClPh	SO2	Single bond	Sub-18
						2-3907	Sub-49	3，4-diClPh	SO2	Single bond	Sub-19
2-3908	Sub-49	3，4-diClPh	SO2	Single bond	Sub-20
						2-3909	Sub-49	3，4-diClPh	SO2	Single bond	Sub-21
2-3910	Sub-49	3，4-diClPh	SO2	Single bond	Sub-22
						2-3911	Sub-49	3，4-diClPh	SO2	Single bond	Sub-23
2-3912	Sub-49	3，4-diClPh	SO2	Single bond	Sub-24
						2-3913	Sub-49	3，4-diClPh	SO2	Single bond	Sub-25
2-3914	Sub-49	3，4-diClPh	SO2	Single bond	Sub-26
						2-3915	Sub-49	3，4-diClPh	SO2	Single bond	Sub-27
2-3916	Sub-49	3，4-diClPh	SO2	Single bond	Sub-28
						2-3917	Sub-49	3，4-diClPh	SO2	Single bond	Sub-29
2-3918	Sub-49	3，4-diClPh	SO2	Single bond	Sub-30
						2-3919	Sub-49	3，4-diClPh	SO2	Single bond	Sub-31
2-3920	Sub-49	3，4-diClPh	SO2	Single bond	Sub-32
						2-3921	Sub-49	3，4-diClPh	SO2	Single bond	Sub-65
2-3922	Sub-49	3，4-diClPh	SO2	Single bond	Sub-66
						2-3923	Sub-49	3，4-diClPh	SO2	Single bond	Sub-67
2-3924	Sub-49	3，4-diClPh	SO2	Single bond	Sub-68
						2-3925	Sub-49	3，4-diClPh	SO2	Single bond	Sub-69
2-3926	Sub-49	3，4-diClPh	SO2	Single bond	Sub-70

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3927	Sub-49	3，4-diClPh	SO2	Single bond	Sub-71
2-3928	Sub-49	3，4-diClPh	SO2	Single bond	Sub-72
						2-3929	Sub-49	3，4-diClPh	SO2	Single bond	Sub-73
2-3930	Sub-49	3，4-diClPh	SO2	Single bond	Sub-74
						2-3931	Sub-49	3，4-diClPh	SO2	Single bond	Sub-75
2-3932	Sub-49	3，4-diClPh	SO2	Single bond	Sub-76
						2-3933	Sub-49	3，4-diClPh	SO2	Single bond	Sub-77
2-3934	Sub-49	3，4-diClPh	SO2	Single bond	Sub-78
						2-3935	Sub-49	3，4-diClPh	SO2	Single bond	Sub-79
2-3936	Sub-49	3，4-diClPh	SO2	Single bond	Sub-80
						2-3937	Sub-50	3，4-diClPh	SO2	Single bond	Sub-1
2-3938	Sub-50	3，4-diClPh	SO2	Single bond	Sub-2
						2-3939	Sub-50	3，4-diClPh	SO2	Single bond	Sub-3
2-3940	Sub-50	3，4-diClPh	SO2	Single bond	Sub-4
						2-3941	Sub-50	3，4-diClPh	SO2	Single bond	Sub-5
2-3942	Sub-50	3，4-diClPh	SO2	Single bond	Sub-6
						2-3943	Sub-50	3，4-diClPh	SO2	Single bond	Sub-7
2-3944	Sub-50	3，4-diClPh	SO2	Single bond	Sub-8
						2-3945	Sub-50	3，4-diClPh	SO2	Single bond	Sub-9
2-3946	Sub-50	3，4-diClPh	SO2	SheetKey with a key body	Sub-10
						2-3947	Sub-50	3，4-diClPh	SO2	Single bond	Sub-11
2-3948	Sub-50	3，4-diClPh	SO2	Single bond	Sub-12
						2-3949	Sub-50	3，4-diClPh	SO2	Single bond	Sub-13
2-3950	Sub-50	3，4-diClPh	SO2	Single bond	Sub-14
						2-3951	Sub-50	3，4-diClPh	SO2	Single bond	Sub-15
2-3952	Sub-50	3，4-diClPh	SO2	Single bond	Sub-16

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3953	Sub-50	3，4-diClPh	SO2	Single bond	Sub-17
2-3954	Sub-50	3，4-diClPh	SO2	Single bond	Sub-18
						2-3955	Sub-50	3，4-diClPh	SO2	Single bond	Sub-19
2-3956	Sub-50	3，4-diClPh	SO2	Single bond	Sub-20
						2-3957	Sub-50	3，4-diClPh	SO2	Single bond	Sub-21
2-3958	Sub-50	3，4-diClPh	SO2	Single bond	Sub-22
						2-3959	Sub-50	3，4-diClPh	SO2	Single bond	Sub-23
2-3960	Sub-50	3，4-diClPh	SO2	Single bond	Sub-24
						2-3961	Sub-50	3，4-diClPh	SO2	Single bond	Sub-25
2-3962	Sub-50	3，4-diClPh	SO2	Single bond	Sub-26
						2-3963	Sub-50	3，4-diClPh	SO2	Single bond	Sub-27
2-3964	Sub-50	3，4-diClPh	SO2	Single bond	Sub-28
						2-3965	Sub-50	3，4-diClPh	SO2	Single bond	Sub-29
2-3966	Sub-50	3，4-diClPh	SO2	Single bond	Sub-30
						2-3967	Sub-50	3，4-diClPh	SO2	Single bond	Sub-31
2-3968	Sub-50	3，4-diClPh	SO2	Single bond	Sub-32
						2-3969	Sub-50	3，4-diClPh	SO2	Single bond	Sub-65
2-3970	Sub-50	3，4-diClPh	SO2	Single bond	Sub-66
						2-3971	Sub-50	3，4-diClPh	SO2	Single bond	Sub-67
2-3972	Sub-50	3，4-diClPh	SO2	Single bond	Sub-68
						2-3973	Sub-50	3，4-diClPh	SO2	Single bond	Sub-69
2-3974	Sub-5O	3，4-diClPh	SO2	Single bond	Sub-70
						2-3975	Sub-50	3，4-diClPh	SO2	Single bond	Sub-71
2-3976	Sub-50	3，4-diClPh	SO2	Single bond	Sub-72
						2-3977	Sub-50	3，4-diClPh	SO2	Single bond	Sub-73
2-3978	Sub-50	3，4-diClPh	SO2	Single bond	Sub-74

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-3979	Sub-50	3，4-diClPh	SO2	Single bond	Sub-75
2-3980	Sub-50	3，4-diClPh	SO2	Single bond	Sub-76
						2-3981	Sub-50	3，4-diClPh	SO2	Single bond	Sub-77
2-3982	Sub-50	3，4-diClPh	SO2	Single bond	Sub-78
						2-3983	Sub-50	3，4-diClPh	SO2	Single bond	Sub-79
2-3984	Sub-50	3，4-diClPh	SO2	Single bond	Sub-80
						2-3985	Sub-51	3，4-diClPh	SO2	Single bond	Sub-1
2-3986	Sub-51	3，4-diClPh	SO2	Single bond	Sub-2
						2-3987	Sub-51	3，4-diClPh	SO2	Single bond	Sub-3
2-3988	Sub-51	3，4-diClPh	SO2	Single bond	Sub-4
						2-3989	Sub-51	3，4-diClPh	SO2	Single bond	Sub-5
2-3990	Sub-51	3，4-diClPh	SO2	Single bond	Sub-6
						2-3991	Sub-51	3，4-diClPh	SO2	Single bond	Sub-7
2-3992	Sub-51	3，4-diClPh	SO2	Single bond	Sub-8
						2-3993	Sub-51	3，4-diClPh	SO2	Single bond	Sub-9
2-3994	Sub-51	3，4-diClPh	SO2	Single bond	Sub-10
						2-3995	Sub-51	3，4-diClPh	SO2	Single bond	Sub-11
2-3996	Sub-51	3，4-diClPh	SO2	Single bond	Sub-12
						2-3997	Sub-51	3，4-diClPh	SO2	Single bond	Sub-13
2-3998	Sub-5l	3，4-diClPh	SO2	Single bond	Sub-14
						2-3999	Sub-51	3，4-diClPh	SO2	Single bond	Sub-15
2-4000	Sub-51	3，4-diClPh	SO2	Single bond	Sub-16
						2-4001	Sub-51	3，4-diClPh	SO2	Single bond	Sub-17
2-4002	Sub-51	3，4-diClPh	SO2	Single bond	Sub-18
						2-4003	Sub-51	3，4-diClPh	SO2	Single bond	Sub-19
2-4004	Sub-51	3，4-diClPh	SO2	Single bond	Sub-20

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4005	Sub-51	3，4-diClPh	SO2	Single bond	Sub-21
2-4006	Sub-51	3，4-diClPh	SO2	Single bond	Sub-22
						2-4007	Sub-51	3，4-diClPh	SO2	Single bond	Sub-23
2-4008	Sub-51	3，4-diClPh	SO2	Single bond	Sub-24
						2-4009	Sub-51	3，4-diClPh	SO2	Single bond	Sub-25
2-4010	Sub-51	3，4-diClPh	SO2	Single bond	Sub-26
						2-4011	Sub-51	3，4-diClPh	SO2	Single bond	Sub-27
2-4012	Sub-51	3，4-diClPh	SO2	Single bond	Sub-28
						2-4013	Sub-51	3，4-diClPh	SO2	Single bond	Sub-29
2-4014	Sub-51	3，4-diClPh	SO2	Single bond	Sub-30
						2-4015	Sub-51	3，4-diClPh	SO2	Single bond	Sub-31
2-4016	Sub-51	3，4-diClPh	SO2	Single bond	Sub-32
						2-4017	Sub-51	3，4-diClPh	SO2	Single bond	Sub-65
2-4018	Sub-51	3，4-diClPh	SO2	Single bond	Sub-66
						2-4019	Sub-51	3，4-diClPh	SO2	Single bond	Sub-67
2-4020	Sub-51	3，4-diClPh	SO2	Single bond	Sub-68
						2-4021	Sub-51	3，4-diClPh	SO2	Single bond	Sub-69
2-4022	Sub-51	3，4-diClPh	SO2	Single bond	Sub-70
						2-4023	Sub-51	3，4-diClPh	SO2	Single bond	Sub-71
2-4024	Sub-51	3，4-diClPh	SO2	Single bond	Sub-72
						2-4025	Sub-51	3，4-diClPh	SO2	Single bond	Sub-73
2-4026	Sub-51	3，4-diClPh	SO2	Single bond	Sub-74
						2-4027	Sub-51	3，4-diClPh	SO2	Single bond	Sub-75
2-4028	Sub-51	3，4-diClPh	SO2	Single bond	Sub-76
						2-4029	Sub-51	3，4-diClPh	SO2	Single bond	Sub-77
2-4030	Sub-51	3，4-diClPh	SO2	Single bond	Sub-78

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4031	Sub-51	3，4-diClPh	SO2	Single bond	Sub-79
2-4032	Sub-51	3，4-diClPh	SO2	Single bond	Sub-80
						2-4033	Sub-52	3，4-diClPh	SO2	Single bond	Sub-1
2-4034	Sub-52	3，4-diClPh	SO2	Single bond	Sub-2
						2-4035	Sub-52	3，4-diClPh	SO2	Single bond	Sub-3
2-4036	Sub-52	3，4-diClPh	SO2	Single bond	Sub-4
						2-4037	Sub-52	3，4-diClPh	SO2	Single bond	Sub-5
2-4038	Sub-52	3，4-diClPh	SO2	Single bond	Sub-6
						2-4039	Sub-52	3，4-diClPh	SO2	Single bond	Sub-7
2-4040	Sub-52	3，4-diClPh	SO2	Single bond	Sub-8
						2-4041	Sub-52	3，4-diClPh	SO2	Single bond	Sub-9
2-4042	Sub-52	3，4-diClPh	SO2	Single bond	Sub-10
						2-4043	Sub-52	3，4-diClPh	SO2	Single bond	Sub-11
2-4044	Sub-52	3，4-diClPh	SO2	Single bond	Sub-12
						2-4045	Sub-52	3，4-diClPh	SO2	Single bond	Sub-13
2-4046	Sub-52	3，4-diClPh	SO2	Single bond	Sub-14
						2-4047	Sub-52	3，4-diClPh	SO2	Single bond	Sub-15
2-4048	Sub-52	3，4-diClPh	SO2	Single bond	Sub-16
						2-4049	Sub-52	3，4-diClPh	SO2	Single bond	Sub-17
2-4050	Sub-52	3，4-diClPh	SO2	Single bond	Sub-18
						2-4051	Sub-52	3，4-diClPh	SO2	Single bond	Sub-19
2-4052	Sub-52	3，4-diClPh	SO2	Single bond	Sub-20
						2-4053	Sub-52	3，4-diClPh	SO2	Single bond	Sub-21
2-4054	Sub-52	3，4-diClPh	SO2	Single bond	Sub-22
						2-4055	Sub-52	3，4-diClPh	SO2	Single bond	Sub-23
2-4056	Sub-52	3，4-diClPh	SO2	Single bond	Sub-24

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4057	Sub-52	3，4-diClPh	SO2	Single bond	Sub-25
2-4058	Sub-52	3，4-diClPh	SO2	Single bond	Sub-26
						2-4059	Sub-52	3，4-diClPh	SO2	Single bond	Sub-27
2-4060	Sub-52	3，4-diClPh	SO2	Single bond	Sub-28
						2-4061	Sub-52	3，4-diClPh	SO2	Single bond	Sub-29
2-4062	Sub-52	3，4-diClPh	SO2	Single bond	Sub-30
						2-4063	Sub-52	3，4-diClPh	SO2	Single bond	Sub-31
2-4064	Sub-52	3，4-diClPh	SO2	Single bond	Sub-32
						2-4065	Sub-52	3，4-diClPh	SO2	Single bond	Sub-65
2-4066	Sub-52	3，4-diClPh	SO2	Single bond	Sub-66
						2-4067	Sub-52	3，4-diClPh	SO2	Single bond	Sub-67
2-4068	Sub-52	3，4-diClPh	SO2	Single bond	Sub-68
						2-4069	Sub-52	3，4-diClPh	SO2	Single bond	Sub-69
2-4070	Sub-52	3，4-diClPh	SO2	Single bond	Sub-70
						2-4071	Sub-52	3，4-diClPh	SO2	Single bond	Sub-71
2-4072	Sub-52	3，4-diClPh	SO2	Single bond	Sub-72
						2-4073	Sub-52	3，4-diClPh	SO2	Single bond	Sub-73
2-4074	Sub-52	3，4-diClPh	SO2	Single bond	Sub-74
						2-4075	Sub-52	3，4-diClPh	SO2	Single bond	Sub-75
2-4076	Sub-52	-，4-diClPh	SO2	Single bond	Sub-76
						2-4077	Sub-52	3，4-diClPh	SO2	Single bond	Sub-77
2-4078	Sub-52	3，4-diClPh	SO2	Single bond	Sub-78
						2-4079	Sub-52	3，4-diClPh	SO2	Single bond	Sub-79
2-4080	Sub-52	3，4-diClPh	SO2	Single bond	Sub-80
						2-4081	Sub-53	3，4-diClPh	SO2	Single bond	Sub-1
2-4082	Sub-53	3，4-diClPh	SO2	Single bond	Sub-2

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4083	Sub-53	3，4-diClPh	SO2	Single bond	Sub-3
2-4084	Sub-53	3，4-diClPh	SO2	Single bond	Sub-4
						2-4085	Sub-53	3，4-diClPh	SO2	Single bond	Sub-5
2-4086	Sub-53	3，4-diClPh	SO2	Single bond	Sub-6
						2-4087	Sub-53	3，4-diClPh	SO2	Single bond	Sub-7
2-4088	Sub-53	3，4-diClPh	SO2	Single bond	Sub-8
						2-4089	Sub-53	3，4-diClPh	SO2	Single bond	Sub-9
2-4090	Sub-53	3，4-diClPh	SO2	Single bond	Sub-10
						2-4091	Sub-53	3，4-diClPh	SO2	Single bond	Sub-11
2-4092	Sub-53	3，4-diClPh	SO2	Single bond	Sub-12
						2-4093	Sub-53	3，4-diClPh	SO2	Single bond	Sub-13
2-4094	Sub-53	3，4-diClPh	SO2	Single bond	Sub-14
						2-4095	Sub-53	3，4-diClPh	SO2	Single bond	Sub-15
2-4096	Sub-53	3，4-diClPh	SO2	Single bond	Sub-16
						2-4097	Sub-53	3，4-diClPh	SO2	Single bond	Sub-17
2-4098	Sub-53	3，4-diClPh	SO2	Single bond	Sub-18
						2-4099	Sub-53	3，4-diClPh	SO2	Single bond	Sub-19
2-4100	Sub-53	3，4-diClPh	SO2	Single bond	Sub-20
						2-4101	Sub-53	3，4-diClPh	SO2	Single bond	Sub-21
2-4102	Sub-53	3，4-diClPh	SO2	Single bond	Sub-22
						2-4103	Sub-53	3，4-diClPh	SO2	Single bond	Sub-23
2-4104	Sub-53	3，4-diClPh	SO2	Single bond	Sub-24
						2-4105	Sub-53	3，4-diClPh	SO2	Single bond	Sub-25
2-4106	Sub-53	3，4-diClPh	SO2	Single bond	Sub-26
						2-4107	Sub-53	3，4-diClPh	SO2	Single bond	Sub-27
2-4108	Sub-53	3，4-diClPh	SO2	Single bond	Sub-28

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4109	Sub-53	3，4-diClPh	SO2	Single bond	Sub-29
2-4110	Sub-53	3，4-diClPh	SO2	Single bond	Sub-30
						2-4111	Sub-53	3，4-diClPh	SO2	Single bond	Sub-31
2-4112	Sub-53	3，4-diClPh	SO2	Single bond	Sub-32
						2-4113	Sub-53	3，4-diClPh	SO2	Single bond	Sub-65
2-4114	Sub-53	3，4-diClPh	SO2	Single bond	Sub-66
						2-4115	Sub-53	3，4-diClPh	SO2	Single bond	Sub-67
2-4116	Sub-53	3，4-diClPh	SO2	Single bond	Sub-68
						2-4117	Sub-53	3，4-diClPh	SO2	Single bond	Sub-69
2-4118	Sub-53	3，4-diClPh	SO2	Single bond	Sub-70
						2-4119	Sub-53	3，4-diClPh	SO2	Single bond	Sub-71
2-4120	Sub-53	3，4-diClPh	SO2	Single bond	Sub-72
						2-4121	Sub-53	3，4-diClPh	SO2	Single bond	Sub-73
2-4122	Sub-53	3，4-diClPh	SO2	Single bond	Sub-74
						2-4123	Sub-53	3，4-diClPh	SO2	Single bond	Sub-75
2-4124	Sub-53	3，4-diClPh	SO2	Single bond	Sub-76
						2-4125	Sub-53	3，4-diClPh	SO2	Single bond	Sub-77
2-4126	Sub-53	3，4-diClPh	SO2	Single bond	Sub-78
						2-4127	Sub-53	3，4-diClPh	SO2	Single bond	Sub-79
2-4128	Sub-53	3，4-diClPh	SO2	Single bond	Sub-80
						2-4129	Sub-54	3，4-diClPh	SO2	Single bond	Sub-1
2-4130	Sub-54	3，4-diClPh	SO2	Single bond	Sub-2
						2-4131	Sub-54	3，4-diClPh	SO2	Single bond	Sub-3
2-4132	Sub-54	3，4-diClPh	SO2	Single bond	Sub-4
						2-4133	Sub-54	3，4-diClPh	SO2	Single bond	Sub-5
2-4134	Sub-54	3，4-diClPh	SO2	Single bond	Sub-6

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4135	Sub-54	3，4-diClPh	SO2	Single bond	Sub-7
2-4136	Sub-54	3，4-diClPh	SO2	Single bond	Sub-8
						2-4137	Sub-54	3，4-diClPh	SO2	Single bond	Sub-9
2-4138	Sub-54	3，4-diClPh	SO2	Single bond	Sub-10
						2-4139	Sub-54	3，4-diClPh	SO2	Single bond	Sub-11
2-4140	Sub-54	3，4-diClPh	SO2	Single bond	Sub-12
						2-4141	Sub-54	3，4-diClPh	SO2	Single bond	Sub-13
2-4142	Sub-54	3，4-diClPh	SO2	Single bond	Sub-14
						2-4143	Sub-54	3，4-diClPh	SO2	Single bond	Sub-15
2-4144	Sub-54	3，4-diClPh	SO2	Single bond	Sub-16
						2-4145	Sub-54	3，4-diClPh	SO2	Single bond	Sub-17
2-4146	Sub-54	3，4-diClPh	SO2	Single bond	Sub-18
						2-4147	Sub-54	3，4-diClPh	SO2	Single bond	Sub-19
2-4148	Sub-54	3，4-diClPh	SO2	Single bond	Sub-20
						2-4149	Sub-54	3，4-diClPh	SO2	Single bond	Sub-21
2-4150	Sub-54	3，4-diClPh	SO2	Single bond	Sub-22
						2-4151	Sub-54	3，4-diClPh	SO2	Single bond	Sub-23
2-4152	Sub-54	3，4-diClPh	SO2	Single bond	Sub-24
						2-4153	Sub-54	3，4-diClPh	SO2	Single bond	Sub-25
2-4154	Sub-54	3，4-diClPh	SO2	Single bond	Sub-26
						2-4155	Sub-54	3，4-diClPh	SO2	Single bond	Sub-27
2-4156	Sub-54	3，4-diClPh	SO2	Single bond	Sub-28
						2-4157	Sub-54	3，4-diClPh	SO2	Single bond	Sub-29
2-4158	Sub-54	3，4-diClPh	SO2	Single bond	Sub-30
						2-4159	Sub-54	3，4-diClPh	SO2	Single bond	Sub-31
2-4160	Sub-54	3，4-diClPh	SO2	Single bond	Sub-32

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4161	Sub-54	3，4-diClPh	SO2	Single bond	Sub-65
2-4162	Sub-54	3，4-diClPh	SO2	Single bond	Sub-66
						2-4163	Sub-54	3，4-diClPh	SO2	Single bond	Sub-67
2-4164	Sub-54	3，4-diClPh	SO2	Single bond	Sub-68
						2-4165	Sub-54	3，4-diClPh	SO2	Single bond	Sub-69
2-4166	Sub-54	3，4-diClPh	SO2	Single bond	Sub-70
						2-4167	Sub-54	3，4-diClPh	SO2	Single bond	Sub-71
2-4168	Sub-54	3，4-diClPh	SO2	Single bond	Sub-72
						2-4169	Sub-54	3，4-diClPh	SO2	Single bond	Sub-73
2-4170	Sub-54	3，4-diClPh	SO2	Single bond	Sub-74
						2-4171	Sub-54	3，4-diClPh	SO2	Single bond	Sub-75
2-4172	Sub-54	3，4-diClPh	SO2	Single bond	Sub-76
						2-4173	Sub-54	3，4-diClPh	SO2	Single bond	Sub-77
2-4174	Sub-54	3，4-diClPh	SO2	Single bond	Sub-78
						2-4175	Sub-54	3，4-diClPh	SO2	Single bond	Sub-79
2-4176	Sub-54	3，4-diClPh	SO2	Single bond	Sub-80
						2-4177	Sub-55	3，4-diClPh	SO2	Single bond	Sub-1
2-4178	Sub-55	3，4-diClPh	SO2	Single bond	Sub-2
						2-4179	Sub-55	3，4-diCiPh	SO2	Single bond	Sub-3
2-4180	Sub-55	3，4-diClPh	SO2	Single bond	Sub-4
						2-4181	Sub-55	3，4-diClPh	SO2	Single bond	Sub-5
2-4182	Sub-55	3，4-diClPh	SO2	Single bond	Sub-6
						2-4183	Sub-55	3，4-diClPh	SO2	Single bond	Sub-7
2-4184	Sub-55	3，4-diClPh	SO2	Single bond	Sub-8
						2-4185	Sub-55	3，4-diClPh	SO2	Single bond	Sub-9
2-4186	Sub-55	3，4-diClPh	SO2	Single bond	Sub-10

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4187	Sub-55	3，4-diClPh	SO2	Single bond	Sub-11
2-4188	Sub-55	3，4-diClPh	SO2	Single bond	Sub-12
						2-4189	Sub-55	3，4-diClPh	SO2	Single bond	Sub-13
2-4190	Sub-55	3，4-diClPh	SO2	Single bond	Sub-14
						2-4191	Sub-55	3，4-diClPh	SO2	Single bond	Sub-15
2-4192	Sub-55	3，4-diClPh	SO2	Single bond	Sub-16
						2-4193	Sub-55	3，4-diClPh	SO2	Single bond	Sub-17
2-4194	Sub-55	3，4-diClPh	SO2	Single bond	Sub-18
						2-4195	Sub-55	3，4-diClPh	SO2	Single bond	Sub-19
2-4196	Sub-55	3，4-diClPh	SO2	Single bond	Sub-20
						2-4197	Sub-55	3，4-diClPh	SO2	Single bond	Sub-21
2-4198	Sub-55	3，4-diClPh	SO2	Single bond	Sub-22
						2-4199	Sub-55	3，4-diClPh	SO2	Single bond	Sub-23
2-4200	Sub-55	3，4-diClPh	SO2	Single bond	Sub-24
						2-4201	Sub-55	3，4-diClPh	SO2	Single bond	Sub-25
2-4202	Sub-55	3，4-diClPh	SO2	Single bond	Sub-26
						2-4203	Sub-55	3，4-diClPh	SO2	Single bond	Sub-27
2-4204	Sub-55	3，4-diClPh	SO2	Single bond	Sub-28
						2-4205	Sub-55	3，4-diClPh	SO2	Single bond	Sub-29
2-4206	Sub-55	3，4-diClPh	SO2	Single bond	Sub-30
						2-4207	Sub-55	3，4-diClPh	SO2	Single bond	Sub-31
2-4208	Sub-55	3，4-diClPh	SO2	Single bond	Sub-32
						2-4209	Sub-55	3，4-diClPh	SO2	Single bond	Sub-65
2-4210	Sub-55	3，4-diClPh	SO2	Single bond	Sub-66
						2-4211	Sub-55	3，4-diClPh	SO2	Single bond	Sub-67
2-4212	Sub-55	3，4-diClPh	SO2	Single bond	Sub-68

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4213	Sub-55	3，4-diClPh	SO2	Single bond	Sub-69
2-4214	Sub-55	3，4-diClPh	SO2	Single bond	Sub-70
						2-4215	Sub-55	3，4-diClPh	SO2	Single bond	Sub-71
2-4216	Sub-55	3，4-diClPh	SO2	Single bond	Sub-72
						2-4217	Sub-55	3，4-diClPh	SO2	Single bond	Sub-73
2-4218	Sub-55	3，4-diClPh	SO2	Single bond	Sub-74
						2-4219	Sub-55	3，4-diClPh	SO2	Single bond	Sub-75
2-4220	Sub-55	3，4-diClPh	SO2	Single bond	Sub-76
						2-4221	Sub-55	3，4-diClPh	SO2	Single bond	Sub-77
2-4222	Sub-55	3，4-diClPh	SO2	Single bond	Sub-78
						2-4223	Sub-55	3，4-diClPh	SO2	Single bond	Sub-79
2-4224	Sub-55	3，4-diClPh	SO2	Single bond	Sub-80
						2-4225	Sub-56	3，4-diClPh	SO2	Single bond	Sub-1
2-4226	Sub-56	3，4-diClPh	SO2	Single bond	Sub-2
						2-4227	Sub-56	3，4-diClPh	SO2	Single bond	Sub-3
2-4228	Sub-56	3，4-diClPh	SO2	Single bond	Sub-4
						2-4229	Sub-56	3，4-diClPh	SO2	Single bond	Sub-5
2-4230	Sub-56	3，4-diClPh	SO2	Single bond	Sub-6
						2-4231	Sub-56	3，4-diClPh	SO2	Single bond	Sub-7
2-4232	Sub-56	3，4-diClPh	SO2	Single bond	Sub-8
						2-4233	Sub-56	3，4-diClPh	SO2	Single bond	Sub-9
2-4234	Sub-56	3，4-diClPh	SO2	Single bond	Sub-10
						2-4235	Sub-56	3，4-diClPh	SO2	Single bond	Sub-11
2-4236	Sub-56	3，4-diClPh	SO2	SheetKey with a key body	Sub-12
						2-4237	Sub-56	3，4-diClPh	SO2	Single bond	Sub-13
2-4238	Sub-56	3，4-diClPh	SO2	Single bond	Sub-14

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4239	Sub-56	3，4-diClPh	SO2	Single bond	Sub-15
2-4240	Sub-56	3，4-diClPh	SO2	Single bond	Sub-16
						2-4241	Sub-56	3，4-diClPh	SO2	Single bond	Sub-17
2-4242	Sub-56	3，4-diClPh	SO2	Single bond	Sub-18
						2-4243	Sub-56	3，4-diClPh	SO2	Single bond	Sub-19
2-4244	Sub-56	3，4-diClPh	SO2	Single bond	Sub-20
						2-4245	Sub-56	3，4-diClPh	SO2	Single bond	Sub-21
2-4246	Sub-56	3，4-diClPh	SO2	Single bond	Sub-22
						2-4247	Sub-56	3，4-diClPh	SO2	Single bond	Sub-23
2-4248	Sub-56	3，4-diClPh	SO2	Single bond	Sub-24
						2-4249	Sub-56	3，4-diClPh	SO2	Single bond	Sub-25
2-4250	Sub-56	3，4-diClPh	SO2	Single bond	Sub-26
						2-4251	Sub-56	3，4-diClPh	SO2	Single bond	Sub-27
2-4252	Sub-56	3，4-diClPh	SO2	Single bond	Sub-28
						2-4253	Sub-56	3，4-diClPh	SO2	Single bond	Sub-29
2-4254	Sub-56	3，4-diClPh	SO2	Single bond	Sub-30
						2-4255	Sub-56	3，4-diClPh	SO2	Single bond	Sub-31
2-4256	Sub-56	3，4-diClPh	SO2	Single bond	Sub-32
						2-4257	Sub-56	3，4-diClPh	SO2	Single bond	Sub-65
2-4258	Sub-56	3，4-diClPh	SO2	Single bond	Sub-66
						2-4259	Sub-56	3，4-diClPh	SO2	Single bond	Sub-67
2-4260	Sub-56	3，4-diClPh	SO2	Single bond	Sub-68
						2-4261	Sub-56	3，4-diClPh	SO2	Single bond	Sub-69
2-4262	Sub-56	3，4-diClPh	SO2	Single bond	Sub-70
						2-4263	Sub-56	3，4-diClPh	SO2	Single bond	Sub-71
2-4264	Sub-56	3，4-diClPh	SO2	Single bond	Sub-72

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4265	Sub-56	3，4-diClPh	SO2	Single bond	Sub-73
2-4266	Sub-56	3，4-diClPh	SO2	Single bond	Sub-74
						2-4267	Sub-56	3，4-diClPh	SO2	Single bond	Sub-75
2-4268	Sub-56	3，4-diClPh	SO2	Single bond	Sub-76
						2-4269	Sub-56	3，4-diClPh	SO2	Single bond	Sub-77
2-4270	Sub-56	3，4-diClPh	SO2	Single bond	Sub-78
						2-4271	Sub-56	3，4-diClPh	SO2	Single bond	Sub-79
2-4272	Sub-56	3，4-diClPh	SO2	Single bond	Sub-80
						2-4273	Sub-57	3，4-diClPh	SO2	Single bond	Sub-1
2-4274	Sub-57	3，4-diClPh	SO2	Single bond	Sub-2
						2-4275	Sub-57	3，4-diClPh	SO2	Single bond	Sub-3
2-4276	Sub-57	3，4-diClPh	SO2	Single bond	Sub-4
						2-4277	Sub-57	3，4-diClPh	SO2	Single bond	Sub-5
2-4278	Sub-57	3，4-diClPh	SO2	Single bond	Sub-6
						2-4279	Sub-57	3，4-diClPh	SO2	Single bond	Sub-7
2-4280	Sub-57	3，4-diClPh	SO2	Single bond	Sub-8
						2-4281	Sub-57	3，4-diClPh	SO2	Single bond	Sub-9
2-4282	Sub-57	3，4-diClPh	SO2	Single bond	Sub-10
						2-4283	Sub-57	3，4-diClPh	SO2	Single bond	Sub-11
2-4284	Sub-57	3，4-diClPh	SO2	Single bond	Sub-12
						2-4285	Sub-57	3，4-diClPh	SO2	Single bond	Sub-13
2-4286	Sub-57	3，4-diClPh	SO2	Single bond	Sub-14
						2-4287	Sub-57	3，4-diClPh	SO2	Single bond	Sub-15
2-4288	Sub-57	3，4-diClPh	SO2	Single bond	Sub-16
						2-4289	Sub-57	3，4-diClPh	SO2	Single bond	Sub-17
2-4290	Sub-57	3，4-diClPh	SO2	Single bond	Sub-18

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4291	Sub-56	3，4-diClPh	SO2	Single bond	Sub-19
2-4292	Sub-56	3，4-diClPh	SO2	Single bond	Sub-20
						2-4293	Sub-56	3，4-diClPh	SO2	Single bond	Sub-21
2-4294	Sub-56	3，4-diClPh	SO2	Single bond	Sub-22
						2-4295	Sub-56	3，4-diClPh	SO2	Single bond	Sub-23
2-4296	Sub-56	3，4-diClPh	SO2	Single bond	Sub-24
						2-4297	Sub-56	3，4-diClPh	SO2	Single bond	Sub-25
2-4298	Sub-56	3，4-diClPh	SO2	Single bond	Sub-26
						2-4299	Sub-57	3，4-diClPh	SO2	Single bond	Sub-27
2-4300	Sub-57	3，4-diClPh	SO2	Single bond	Sub-28
						2-4301	Sub-57	3，4-diClPh	SO2	Single bond	Sub-29
2-4302	Sub-57	3，4-diClPh	SO2	Single bond	Sub-30
						2-4303	Sub-57	3，4-diClPh	SO2	Single bond	Sub-31
2-4304	Sub-57	3，4-diClPh	SO2	Single bond	Sub-32
						2-4305	Sub-57	3，4-diClPh	SO2	Single bond	Sub-65
2-4306	Sub-57	3，4-diClPh	SO2	Single bond	Sub-66
						2-4307	Sub-57	3，4-diClPh	SO2	Single bond	Sub-67
2-4308	Sub-57	3，4-diClPh	SO2	Single bond	Sub-68
						2-4309	Sub-57	3，4-diClPh	SO2	Single bond	Sub-69
2-4310	Sub-57	3，4-diClPh	SO2	Single bond	Sub-70
						2-4311	Sub-57	3，4-diClPh	SO2	Single bond	Sub-71
2-4312	Sub-57	3，4-diClPh	SO2	Single bond	Sub-72
						2-4313	Sub-57	3，4-diClPh	SO2	Single bond	Sub-73
2-4314	Sub-57	3，4-diClPh	SO2	Single bond	Sub-74
						2-4315	Sub-57	3，4-diClPh	SO2	Single bond	Sub-75
2-4316	Sub-57	3，4-diClPh	SO2	Single bond	Sub-76

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4317	Sub-57	3，4-diClPh	SO2	Single bond	Sub-77
2-4318	Sub-57	3，4-diClPh	SO2	Single bond	Sub-78
						2-4319	Sub-57	3，4-diClPh	SO2	Single bond	Sub-79
2-4320	Sub-57	3，4-diClPh	SO2	Single bond	Sub-80
						2-4321	Sub-58	3 ，4-diClPh	SO2	Single bond	Sub-1
2-4322	Sub-58	3，4-diClPh	SO2	Single bond	Sub-2
						2-4323	Sub-58	3，4-diClPh	SO2	Single bond	Sub-3
2-4324	Sub-58	3，4-diClPh	SO2	Single bond	Sub-4
						2-4325	Sub-58	3，4-diClPh	SO2	Single bond	Sub-5
2-4326	Sub-58	3，4-diClPh	SO2	Single bond	Sub-6
						2-4327	Sub-58	3，4-diClPh	SO2	Single bond	Sub-7
2-4328	Sub-58	3，4-diClPh	SO2	Single bond	Sub-8
						2-4329	Sub-58	3，4-diClPh	SO2	Single bond	Sub-9
2-4330	Sub-58	3，4-diClPh	SO2	Single bond	Sub-10
						2-4331	Sub-58	3，4-diClPh	SO2	Single bond	Sub-11
2-4332	Sub-58	3，4-diClPh	SO2	Single bond	Sub-12
						2-4333	Sub-58	3，4-diClPh	SO2	Single bond	Sub-13
2-4334	Sub-58	3，4-diClPh	SO2	Single bond	Sub-14
						2-4335	Sub-58	3，4-diClPh	SO2	Single bond	Sub-15
2-4336	Sub-58	3，4-diClPh	SO2	Single bond	Sub-16
						2-4337	Sub-58	3，4-diClPh	SO2	Single bond	Sub-17
2-4338	Sub-58	3，4-diClPh	SO2	Single bond	Sub-18
						2-4339	Sub-58	3，4-diClPh	SO2	Single bond	Sub-19
2-4340	Sub-58	3，4-diClPh	SO2	Single bond	Sub-20
						2-4341	Sub-58	3，4-diClPh	SO2	Single bond	Sub-21
2-4342	Sub-58	3，4-diClPh	SO2	Single bond	Sub-22

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4343	Sub-58	3，4-diClPh	SO2	Single bond	Sub-23
2-4344	Sub-58	3，4-diClPh	SO2	Single bond	Sub-24
						2-4345	Sub-58	3，4-diClPh	SO2	Single bond	Sub-25
2-4346	Sub-58	3，4-diClPh	SO2	Single bond	Sub-26
						2-4347	Sub-58	3，4-diClPh	SO2	Single bond	Sub-27
2-4348	Sub-58	3，4-diClPh	SO2	Single bond	Sub-28
						2-4349	Sub-58	3，4-diClPh	SO2	Single bond	Sub-29
2-4350	Sub-58	3，4-diClPh	SO2	Single bond	Sub-30
						2-4351	Sub-58	3，4-diClPh	SO2	Single bond	Sub-31
2-4352	Sub-58	3，4-diClPh	SO2	Single bond	Sub-32
						2-4353	Sub-58	3，4-diClPh	SO2	Single bond	Sub-65
2-4354	Sub-58	3，4-diClPh	SO2	Single bond	Sub-66
						2-4355	Sub-58	3，4-diClPh	SO2	Single bond	Sub-67
2-4356	Sub-58	3，4-diClPh	SO2	Single bond	Sub-68
						2-4357	Sub-58	3，4-diClPh	SO2	Single bond	Sub-69
2-4358	Sub-58	3，4-diClPh	SO2	Single bond	Sub-70
						2-4359	Sub-58	3，4-diClPh	SO2	Single bond	Snb-71
2-4360	Sub-58	3，4-diClPh	SO2	Single bond	Sub-72
						2-4361	Sub-58	3，4-diClPh	SO2	Single bond	Sub-73
2-4362	Sub-58	3，4-diClPh	SO2	Single bond	Sub-74
						2-4363	Sub-58	3，4-diClPh	SO2	Single bond	Sub-75
2-4364	Sub-58	3，4-diClPh	SO2	Single bond	Sub-76
						2-4365	Sub-58	3，4-diClPh	SO2	Single bond	Sub-77
2-4366	Sub-58	3，4-diClPh	SO2	Single bond	Sub-78
						2-4367	Sub-58	3，4-diClPh	SO2	Single bond	Sub-79
2-4368	Sub-58	3，4-diClPh	SO2	Single bond	Sub-80

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4369	Sub-59	3，4-diClPh	SO2	Single bond	Sub-1
2-4370	Sub-59	3，4-diClPh	SO2	Single bond	Sub-2
						2-4371	Sub-59	3，4-diClPh	SO2	Single bond	Sub-3
2-4372	Sub-59	3，4-diClPh	SO2	Single bond	Sub-4
						2-4373	Sub-59	3，4-diClPh	SO2	Single bond	Sub-5
2-4374	Sub-59	3，4-diClPh	SO2	Single bond	Sub-6
						2-4375	Sub-59	3，4-diClPh	SO2	Single bond	Sub-7
2-4376	Sub-59	3，4-diClPh	SO2	Single bond	Sub-8
						2-4377	Sub-59	3，4-diClPh	SO2	Single bond	Sub-9
2-4378	Sub-59	3，4-diClPh	SO2	Single bond	Sub-10
						2-4379	Sub-59	3，4-diClPh	SO2	Single bond	Sub-11
2-4380	Sub-59	3，4-diClPh	SO2	Single bond	Sub-12
						2-4381	Sub-59	3，4-diClPh	SO2	Single bond	Sub-13
2-4382	Sub-59	3，4-diClPh	SO2	Single bond	Sub-14
						2-4383	Sub-59	3，4-diClPh	SO2	Single bond	Sub-15
2-4384	Sub-59	3，4-diClPh	SO2	Single bond	Sub-16
						2-4385	Sub-59	3，4-diClPh	SO2	Single bond	Sub-17
2-4386	Sub-59	3，4-diClPh	SO2	Single bond	Sub-18
						2-4387	Sub-59	3，4-diClPh	SO2	Single bond	Sub-19
2-4388	Sub-59	3，4-diClPh	SO2	Single bond	Sub-20
						2-4389	Sub-59	3，4-diClPh	SO2	Single bond	Sub-21
2-4390	Sub-59	3，4-diClPh	SO2	Single bond	Sub-22
						2-4391	Sub-59	3，4-diClPh	SO2	Single bond	Sub-23
2-4392	Sub-59	3，4-diCiCh	SO2	Single bond	Sub-24
						2-4393	Sub-59	3，4-diClPh	SO2	Single bond	Sub-25
2-4394	Sub-59	3，4-diClPh	SO2	Single bond	Sub-26

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4395	Sub-59	3，4-diClPh	SO2	Single bond	Sub-27
2-4396	Sub-59	3，4-diClPh	SO2	Single bond	Sub-28
						2-4397	Sub-59	3，4-diClPh	SO2	Single bond	Sub-29
2-4398	Sub-59	3，4-diClPh	SO2	Single bond	Sub-30
						2-4399	Sub-59	3，4-diClPh	SO2	Single bond	Sub-31
3-4400	Sub-59	3，4-diClPh	SO2	Single bond	Sub-32
						2-4401	Sub-59	3，4-diClPh	SO2	Single bond	Sub-65
2-4402	Sub-59	3，4-diClPh	SO2	Single bond	Sub-66
						2-4403	Sub-59	3，4-diClPh	SO2	Single bond	Sub-67
2-4404	Sub-59	3，4-diClPh	SO2	Single bond	Sub-68
						2-4405	Sub-59	3，4-diClPh	SO2	Single bond	Sub-69
2-4406	Sub-59	3，4-diClPh	SO2	Single bond	Sub-70
						2-4407	Sub-59	3，4-diClPh	SO2	Single bond	Sub-71
2-4408	Sub-59	3，4-diClPh	SO2	Single bond	Sub-72
						2-4409	Sub-59	3，4-diClPh	SO2	Single bond	Sub-73
2-4410	Sub-59	3，4-diClPh	SO2	Single bond	Sub-74
						2-4411	Sub-59	3，4-diClPh	SO2	Single bond	Sub-75
2-4412	Sub-59	3，4-diClPh	SO2	Single bond	Sub-76
						2-4413	Sub-59	3，4-diClPh	SO2	Single bond	Sub-77
2-4414	Sub-59	3，4-diClPh	SO2	Single bond	Sub-78
						2-4415	Sub-59	3，4-diClPh	SO2	Single bond	Sub-79
2-4416	Sub-59	3，4-diClPh	SO2	Single bond	Sub-80
						2-4417	Sub-82	3，4-diClPh	SO2	Single bond	Sub-1
2-4418	Sub-82	3，4-diClPh	SO2	Single bond	Sub-2
						2-4419	Sub-82	3，4-diClPh	SO2	Single bond	Sub-3
2-4420	Sub-82	3，4-diClPh	SO2	Single bond	Sub-4

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4421	Sub-82	3，4-diClPh	SO2	Single bond	Sub-5
2-4422	Sub-82	3，4-diClPh	SO2	Single bond	Sub-6
						2-4423	Sub-82	3，4-diClPh	SO2	Single bond	Sub-7
2-4424	Sub-82	3，4-diClPh	SO2	Single bond	Sub-8
						2-4425	Sub-82	3，4-diClPh	SO2	Single bond	Sub-9
3-4426	Sub-82	3，4-diClPh	SO2	Single bond	Sub-10
						2-4427	Sub-82	3，4-diClPh	SO2	Single bond	Sub-11
2-4428	Sub-82	3，4-diClPh	SO2	Single bond	Sub-12
						2-4429	Sub-82	3，4-diClPh	SO2	Single bond	Sub-13
2-4430	Sub-82	3，4-diClPh	SO2	Single bond	Sub-14
						2-4431	Sub-82	3，4-diClPh	SO2	Single bond	Sub-15
2-4432	Sub-82	3，4-diClPh	SO2	Single bond	Sub-16
						2-4433	Sub-82	3，4-diClPh	SO2	Single bond	Sub-17
2-4434	Sub-82	3，4-diClPh	SO2	Single bond	Sub-18
						2-4435	Sub-82	3，4-diClPh	SO2	Single bond	Sub-19
2-4436	Sub-82	3，4-diClPh	SO2	Single bond	Sub-20
						2-4437	Sub-82	3，4-diClPh	SO2	Single bond	Sub-21
2-4438	Sub-82	3，4-diClPh	SO2	Single bond	Sub-22
						2-4439	Sub-82	3，4-diClPh	SO2	Single bond	Sub-23
2-4440	Sub-82	3，4-diClPh	SO2	Single bond	Sub-24
						2-4441	Sub-82	3，4-diClPh	SO2	Single bond	Sub-25
2-4442	Sub-82	3，4-diClPh	SO2	Single bond	Sub-26
						2-4443	Sub-82	3，4-diClPh	SO2	Single bond	Sub-27
2-4444	Sub-82	3，4-diClPh	SO2	Single bond	Sub-28
						2-4445	Sub-82	3，4-diClPh	SO2	Single bond	Sub-29
2-4446	Sub-82	3，4-diClPh	SO2	Single bond	Sub-30

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4447	Sub-82	3，4-diClPh	SO2	Single bond	Sub-31
2-4448	Sub-82	3，4-diClPh	SO2	Single bond	Sub-32
						2-4449	Sub-82	3，4-diClPh	SO2	Single bond	Sub-65
2-4450	Sub-82	3，4-diClPh	SO2	Single bond	Sub-66
						2-4451	Sub-82	3，4-diClPh	SO2	Single bond	Sub-67
2-4452	Sub-82	3，4-diClPh	SO2	Single bond	Sub-68
						2-4453	Sub-82	3，4-diClPh	SO2	Single bond	Sub-69
2-4454	Sub-82	3，4-diClPh	SO2	Single bond	Sub-70
						2-4455	Sub-82	3，4-diClPh	SO2	Single bond	Sub-71
2-4456	Sub-82	3，4-diClPh	SO2	Single bond	Sub-72
						2-4457	Sub-82	3，4-diClPh	SO2	Single bond	Sub-73
2-4458	Sub-82	3，4-diClPh	SO2	Single bond	Sub-74
						2-4459	Sub-82	3，4-diClPh	SO2	Single bond	Sub-75
2-4460	Sub-82	3，4-diClPh	SO2	Single bond	Sub-76
						2-4461	Sub-82	3，4-diClPh	SO2	Single bond	Sub-77
2-4462	Sub-82	3，4-diClPh	SO2	Single bond	Sub-78
						2-4463	Sub-82	3，4-diClPh	SO2	Single bond	Sub-79
2-4464	Sub-82	3，4-diClPh	SO2	Single bond	Sub-80
						2-4465	Sub-83	3，4-diClPh	SO2	Single bond	Sub-1
2-4466	Sub-83	3，4-diClPh	SO2	Single bond	Sub-2
						2-4467	Sub-83	3，4-diClPh	SO2	Single bond	Sub-3
2-4468	Sub-83	3，4-diClPh	SO2	Single bond	Sub-4
						2-4469	Sub-83	3，4-diClPh	SO2	Single bond	Sub-5
2-4470	Sub-83	3，4-diClPh	SO2	Single bond	Sub-6
						2-4471	Sub-83	3，4-diClPh	SO2	Single bond	Sub-7
2-4472	Sub-83	3，4-diClPh	SO2	Single bond	Sub-8

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4473	Sub-83	3，4-diClPh	SO2	Single bond	Sub-9
2-4474	Sub-83	3，4-diClPh	SO2	Single bond	Sub-10
						2-4475	Sub-83	3，4-diClPh	SO2	Single bond	Sub-11
2-4476	Sub-83	3，4-diClPh	SO2	Single bond	Sub-12
						2-4477	Sub-83	3，4-diClPh	SO2	Single bond	Sub-13
2-4478	Sub-83	3，4-diClPh	SO2	Single bond	Sub-14
						2-4479	Sub-83	3，4-diClPh	SO2	Single bond	Sub-15
2-4480	Sub-83	3，4-diClPh	SO2	Single bond	Sub-16
						2-4481	Sub-83	3，4-diClPh	SO2	Single bond	Sub-17
2-4482	Sub-83	3，4-diClPh	SO2	Single bond	Sub-18
						2-4483	Sub-83	3，4-diClPh	SO2	Single bond	Sub-19
2-4484	Sub-83	3，4-diClPh	SO2	Single bond	Sub-20
						2-4485	Sub-83	3，4-diClPh	SO2	Single bond	Sub-21
2-4486	Sub-83	3，4-diClPh	SO2	Single bond	Sub-22
						2-4487	Sub-83	3，4-diClPh	SO2	Single bond	Sub-23
2-4488	Sub-83	3，4-diClPh	SO2	Single bond	Sub-24
						2-4489	Sub-83	3，4-diClPh	SO2	Single bond	Sub-25
2-4490	Sub-83	3，4-diClPh	SO2	Single bond	Sub-26
						2-4491	Sub-83	3，4-diClPh	SO2	Single bond	Sub-27
2-4492	Sub-83	3，4-diClPh	SO2	Single bond	Sub-28
						2-4493	Sub-83	3，4-diClPh	SO2	Single bond	Sub-29
2-4494	Sub-83	3，4-diClPh	SO2	Single bond	Sub-30
						2-4495	Sub-83	3，4-diClPh	SO2	Single bond	Sub-31
2-4496	Sub-83	3，4-diClPh	SO2	Single bond	Sub-32
						2-4497	Sub-83	3，4-diClPh	SO2	Single bond	Sub-65
2-4498	Sub-83	3，4-diClPh	SO2	Single bond	Sub-66

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4499	Sub-83	3，4-diClPh	SO2	Single bond	Sub-67
2-4500	Sub-83	3，4-diClPh	SO2	Single bond	Sub-68
						2-4501	Sub-83	3，4-diClPh	SO2	Single bond	Sub-69
2-4502	Sub-83	3，4-diClPh	SO2	Single bond	Sub-70
						2-4503	Sub-83	3，4-diClPh	SO2	Single bond	Sub-71
2-4504	Sub-83	3，4-diClPh	SO2	Single bond	Sub-72
						2-4505	Sub-83	3，4-diClPh	SO2	Single bond	Sub-73
2-4506	Sub-83	3，4-diClPh	SO2	Single bond	Sub-74
						2-4507	Sub-83	3，4-diClPh	SO2	Single bond	Sub-75
2-4508	Sub-83	3，4-diClPh	SO2	Single bond	Sub-76
						2-4509	Sub-83	3，4-diClPh	SO2	Single bond	Sub-77
2-4510	Sub-83	3，4-diClPh	SO2	Single bond	Sub-78
						2-4511	Sub-83	3，4-diClPh	SO2	Single bond	Sub-79
2-4512	Sub-83	3，4-diClPh	SO2	Single bond	Sub-80
						2-4513	Sub-61	3，4-diClPh	SO2	Single bond	Sub-1
2-4514	Sub-61	3，4-diClPh	SO2	Single bond	Sub-2
						2-4515	Sub-61	3，4-diClPh	SO2	Single bond	Sub-3
2-4516	Sub-61	3，4-diClPh	SO2	Single bond	Sub-4
						2-4517	Sub-61	3，4-diClPh	SO2	Single bond	Sub-5
2-4518	Sub-61	3，4-diClPh	SO2	Single bond	Sub-6
						2-4519	Sub-61	3，4-diClPh	SO2	Single bond	Sub-7
2-4520	Sub-61	3，4-diClPh	SO2	Single bond	Sub-8
						2-4521	Sub-61	3，4-diClPh	SO2	Single bond	Sub-9
2-4522	Sub-61	3，4-diClPh	SO2	Single bond	Sub-10
						2-4523	Sub-61	3，4-diClPh	SO2	Single bond	Sub-11
2-4524	Sub-61	3，4-diClPh	SO2	Single bond	Sub-12

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4525	Sub-61	3，4-diClPh	SO2	Single bond	Sub-13
2-4526	Sub-61	3，4-diClPh	SO2	Single bond	Sub-14
						2-4527	Sub-61	3，4-diClPh	SO2	Single bond	Sub-15
2-4528	Sub-61	3，4-diClPh	SO2	Single bond	Sub-16
						2-4529	Sub-61	3，4-diClPh	SO2	Single bond	Sub-17
2-4530	Sub-61	3，4-diClPh	SO2	Single bond	Sub-18
						2-4531	Sub-61	3，4-diClPh	SO2	Single bond	Sub-19
2-4532	Sub-61	3，4-diClPh	SO2	Single bond	Sub-20
						2-4533	Sub-61	3，4-diClPh	SO2	Single bond	Sub-21
2-4534	Sub-61	3，4-diClPh	SO2	Single bond	Sub-22
						2-4535	Sub-61	3，4-diClPh	SO2	Single bond	Sub-23
2-4536	Sub-61	3，4-diClPh	SO2	Single bond	Sub-24
						2-4537	Sub-61	3，4-diClPh	SO2	Single bond	Sub-25
2-4538	Sub-61	3，4-diClPh	SO2	Single bond	Sub-26
						2-4539	Sub-61	3，4-diClPh	SO2	Single bond	Sub-27
2-4540	Sub-61	3，4-diClPh	SO2	Single bond	Sub-28
						2-4541	Sub-61	3，4-diClPh	SO2	Single bond	Sub-29
2-4542	Sub-61	3，4-diClPh	SO2	Single bond	Sub-30
						2-4543	Sub-61	3，4-diClPh	SO2	Single bond	Sub-31
2-4544	Sub-61	3，4-diClPh	SO2	Single bond	Sub-32
						2-4545	Sub-61	3，4-diClPh	SO2	Single bond	Sub-65
2-4546	Sub-61	3，4-diClPh	SO2	Single bond	Sub-66
						2-4547	Sub-61	3，4-diClPh	SO2	Single bond	Sub-67
2-4548	Sub-61	3，4-diClPh	SO2	Single bond	Sub-68
						2-4549	Sub-61	3，4-diClPh	SO2	Single bond	Sub-69
2-4550	Sub-61	3，4-diClPh	SO2	Single bond	Sub-70

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4551	Sub-61	3，4-diClPh	SO2	Single bond	Sub-71
2-4552	Sub-61	3，4-diClPh	SO2	Single bond	Sub-72
						2-4553	Sub-61	3，4-diClPh	SO2	Single bond	Sub-73
2-4554	Sub-61	3，4-diClPh	SO2	Single bond	Sub-74
						2-4555	Sub-61	3，4-diClPh	SO2	Single bond	Sub-75
2-4556	Sub-61	3，4-diClPh	SO2	Single bond	Sub-76
						2-4557	Sub-61	3，4-diClPh	SO2	Single bond	Sub-77
2-4558	Sub-61	3，4-diClPh	SO2	Single bond	Sub-78
						2-4559	Sub-61	3，4-diClPh	SO2	Single bond	Sub-79
2-4560	Sub-61	3，4-diClPh	SO2	Single bond	Sub-80
						2-4561	Sub-60	3，4-diClPh	SO2	Single bond	Sub-1
2-4562	Sub-6u	3，4-diClPh	SO2	Single bond	Sub-2
						2-4563	Sub-60	3，4-diClPh	SO2	Single bond	Sub-3
2-4564	Sub-60	3，4-diClPh	SO2	Single bond	Sub-4
						2-4565	Sub-60	3，4-diClPh	SO2	Single bond	Sub-5
2-4566	Sub-60	3，4-diClPh	SO2	Single bond	Sub-6
						2-4567	Sub-60	3，4-diClPh	SO2	Single bond	Sub-7
2-4568	Sub-60	3，4-diClPh	SO2	SheetKey with a key body	Sub-8
						2-4569	Sub-60	3，4-diClPh	SO2	Single bond	Sub-9
2-4570	Sub-60	3，4-diClPh	SO2	Single bond	Sub-10
						2-4571	Sub-60	3，4-diClPh	SO2	Single bond	Sub-11
2-4572	Sub-60	3，4-diClPh	SO2	Single bond	Sub-12
						2-4573	Sub-60	3，4-diClPh	SO2	Single bond	Sub-13
2-4574	Sub-60	3，4-diClPh	SO2	Single bond	Sub-14
						2-4575	Sub-60	3，4-diClPh	SO2	Single bond	Sub-15
2-4576	Sub-60	3，4-diClPh	SO2	Single bond	Sub-16

Table 2(cont.)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4577	Sub-60	3，4-diClPh	SO2	Single bond	Sub-17
2-4578	Sub-60	3，4-diClPh	SO2	Single bond	Sub-18
						2-4579	Sub-60	3，4-diClPh	SO2	Single bond	Sub-19
2-4580	Sub-60	3，4-diClPh	SO2	Single bond	Sub-20
						2-4581	Sub-60	3，4-diClPh	SO2	Single bond	Sub-21
2-4582	Sub-60	3，4-diClPh	SO2	Single bond	Sub-22
						2-4583	Sub-60	3，4-diClPh	SO2	Single bond	Sub-23
2-4584	Sub-60	3，4-diClPh	SO2	Single bond	Sub-24
						2-4585	Sub-60	3，4-diClPh	SO2	Single bond	Sub-25
2-4586	Sub-60	3，4-diClPh	SO2	Single bond	Sub-26
						2-4587	Sub-60	3，4-diClPh	SO2	Single bond	Sub-27
2-4588	Sub-60	3，4-diClPh	SO2	Single bond	Sub-28
						2-4589	Sub-60	3，4-diClPh	SO2	Single bond	Sub-29
2-4590	Sub-60	3，4-diClPh	SO2	Single bond	Sub-30
						2-4591	Sub-60	3，4-diClPh	SO2	Single bond	Sub-31
2-4592	Sub-60	3，4-diClPh	SO2	Single bond	Sub-32
						2-4593	Sub-60	3，4-diClPh	SO2	Single bond	Sub-65
2-4594	Sub-60	3，4-diClPh	SO2	Single bond	Sub-66
						2-4595	Sub-60	3，4-diClPh	SO2	Single bond	Sub-67
2-4596	Sub-60	3，4-diClPh	SO2	Single bond	Sub-68
						2-4597	Sub-60	3，4-diClPh	SO2	Single bond	Sub-69
2-4598	Sub-60	3，4-diClPh	SO2	Single bond	Sub-70
						2-4599	Sub-60	3，4-diClPh	SO2	Single bond	Sub-71
2-4600	Sub-60	3，4-diClPh	SO2	Single bond	Sub-72
						2-4601	Sub-60	3，4-diClPh	SO2	Single bond	Sub-73
2-4602	Sub-60	3，4-diClPh	SO2	Single bond	Sub-74

Table 2(contc)

Compound (I) Serial number	R1	R2	A	B	Z
						2-4603	Sub-60	3，4-diClPh	SO2	Single bond	Sub-75
2-4604	Sub-60	3，4-diClPh	SO2	Single bond	Sub-76
						2-4605	Sub-60	3，4-diClPh	SO2	Single bond	Sub-77
2-4606	Sub-60	3，4-diClPh	SO2	Single bond	Sub-78
						2-4607	Sub-60	3，4-diClPh	SO2	Single bond	Sub-79
2-4608	Sub-60	3，4-diClPh	SO2	Single bond	Sub-80

TABLE 3

Compound (I) Serial number	R1	R2	A	B	E
						3-1	Sub-33	3，4-diClPh	-CO-	Single bond	-CH2-
3-2	Sub-34	3，4-diClPh	-CO-	Single bond	-CH2-
						3-3	Sub-35	3，4-diClPh	-CO-	Single bond	-CH2-
3-4	Sub-36	3，4-diClPh	-CO-	Single bond	-CH2-
						3-5	Sub-37	3，4-diClPh	-CO-	Single bond	-CH2-
3-6	Sub-38	3，4-diClPh	-CO-	Single bond	-CH2-
						3-7	Sub-39	3，4-diClPh	-CO-	Single bond	-CH2-
3-8	Sub-40	3，4-diClPh	-CO-	Single bond	-CH2-
						3-9	Sub-41	3，4-diClPh	-CO-	Single bond	-CH2-
3-10	Sub-42	3，4-diClPh	-CO-	Single bond	-CH2-
						3-11	Sub-84	3，4-diClPh	-CO-	Single bond	-CH2-
3-12	Sub-43	3，4-diClPh	-CO-	Single bond	-CH2-
						3-13	Sub-44	3，4-diClPh	-CO-	Single bond	-CH2-
3-14	Sub-45	3，4-diClPh	-CO-	Single bond	-CH2-
						3-15	Sub-46	3，4-diClPh	-CO-	Single bond	-CH2-
3-16	Sub-47	3，4-diClPh	-CO-	Single bond	-CH2-
						3-17	Sub-81	3，4-diClPh	-CO-	Single bond	-CH2-
3-18	Sub-48	3，4-diClPh	-CO-	Single bond	-CH2-
						3-19	Sub-49	3，4-diClPh	-CO-	Single bond	-CH2-
3-20	Sub-50	3，4-diClPh	-CO-	Single bond	-CH2-
						3-21	Sub-51	3，4-diClPh	-CO-	Single bond	-CH2-
3-22	Sub-52	3，4-diClPh	-CO-	Single bond	-CH2-
						3-23	Sub-53	3，4-diClPh	-CO-	Single bond	-CH2-
3-24	Sub-54	3，4-diClPh	-CO-	Single bond	-CH2-
						3-25	Sub-56	3，4-diClPh	-CO-	Single bond	-CH2-
3-26	Sub-57	3，4-diClPh	-CO-	Single bond	-CH2-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-27	Sub-58	3，4-diClPh	-CO-	Single bond	-CH2-
3-28	Sub-59	3，4-diClPh	-CO-	Single bond	-CH2-
						3-29	Sub-82	3，4-diClPh	-CO-	Single bond	-CH2-
3-30	Sub-83	3，4-diClPh	-CO-	Single bond	-CH2-
						3-31	Sub-61	3，4-diClPh	-CO-	Single bond	-CH2-
3-32	Sub-55	3，4-diClPh	-CO-	Single bond	-CH2-
						3-33	Sub-33	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-34	Sub-34	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-35	Sub-35	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-36	Sub-36	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-37	Sub-37	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-38	Sub-38	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-39	Sub-39	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-40	Sub-40	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-41	Sub-41	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-42	Sub-42	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-43	Sub-84	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-44	Sub-43	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-45	Sub-44	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-46	Sub-45	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-47	Sub-46	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-48	Sub-47	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-49	Sub-81	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-50	Sub-48	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-51	Sub-49	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-52	Sub-50	3，4-diClPh	-CO-	Single bond	-CH2CH2-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-53	Sub-51	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-54	Sub-52	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-55	Sub-53	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-56	Sub-54	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-57	Sub-56	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-58	Sub-57	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-59	Sub-58	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-60	Sub-59	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-61	Sub-82	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-62	Sub-83	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-63	Sub-61	3，4-diClPh	-CO-	Single bond	-CH2CH2-
3-64	Sub-55	3，4-diClPh	-CO-	Single bond	-CH2CH2-
						3-65	Sub-33	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-66	Sub-34	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-67	Sub-35	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-68	Sub-36	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-69	Sub-37	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-70	Sub-38	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-71	Sub-39	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-72	Sub-40	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-73	Sub-41	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-74	Sub-42	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-75	Sub-84	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-76	Sub-43	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-77	Sub-44	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-78	Sub-45	3，4-diClPh	-CO-	Single bond	-(CH2)3-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-79	Sub-46	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-80	Sub-47	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-81	Sub-81	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-82	Sub-48	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-83	Sub-49	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-84	Sub-50	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-85	Sub-51	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-86	Sub-52	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-87	Sub-53	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-88	Sub-54	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-89	Sub-56	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-90	Sub-57	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-91	Sub-58	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-92	Sub-59	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-93	Sub-82	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-94	Sub-83	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-95	Sub-61	3，4-diClPh	-CO-	Single bond	-(CH2)3-
3-96	Sub-55	3，4-diClPh	-CO-	Single bond	-(CH2)3-
						3-97	Sub-33	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-98	Sub-34	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-99	Sub-35	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-100	Sub-36	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-101	Sub-37	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-102	Sub-38	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-103	Sub-39	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-104	Sub-40	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-105	Sub-41	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-106	Sub-42	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-107	Sub-84	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-108	Sub-43	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-109	Sub-44	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-110	Sub-45	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-111	Sub-46	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-112	Sub-47	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-113	Sub-81	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-114	Sub-48	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-115	Sub-49	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-116	Sub-50	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-117	Sub-51	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-118	Sub-52	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-119	Sub-53	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-120	Sub-54	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-121	Sub-56	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-122	Sub-57	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-123	Sub-58	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-124	Sub-59	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-125	Sub-82	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-126	Sub-83	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-127	Sub-61	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
3-128	Sub-55	3，4-diClPh	-CO-	Single bond	-CH2C(Me)2-
						3-129	Sub-33	3，4-diClPh	-CO-	Single bond	-CH2-cPR-
3-130	Sub-34	3，4-diClPh	-CO-	Single bond	-CH2-cPR-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-131	Sub-35	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-132	Sub-36	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
						3-133	Sub-37	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-134	Sub-38	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
						3-135	Sub-39	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-136	Sub-40	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
						3-137	Sub-41	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-138	Sub-42	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
						3-139	Sub-84	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-140	Sub-43	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
						3-141	Sub-44	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-142	Sub-45	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
						3-143	Sub-46	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-144	Sub-47	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
						3-145	Sub-81	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-146	Sub-48	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
						3-147	Sub-49	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-148	Sub-50	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
						3-149	Sub-51	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-150	Sub-52	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
						3-151	Sub-53	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-152	Sub-54	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
						3-153	Sub-56	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-154	Sub-57	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
						3-155	Sub-58	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-156	Sub-59	3，4-diClPh	-CO-	Single bond	-CH2-cPr-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-157	Sub-82	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-158	Sub-83	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
						3-159	Sub-61	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
3-160	Sub-55	3，4-diClPh	-CO-	Single bond	-CH2-cPr-
						3-161	Sub-33	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-162	Sub-34	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-163	Sub-35	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-164	Sub-36	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-165	Sub-37	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-166	Sub-38	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-167	Sub-39	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-168	Sub-40	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-169	Sub-41	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-170	Sub-42	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-171	Sub-84	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-172	Sub-43	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-173	Sub-44	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-174	Sub-45	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-175	Sub-46	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-176	Sub-47	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-177	Sub-81	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-178	Sub-48	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-179	Sub-49	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-180	Sub-50	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-181	Sub-51	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-182	Sub-52	3，4-diClPh	-CO-	Single bond	-CH2-cBu-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-183	Sub-53	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-184	Sub-54	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-185	Sub-56	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-186	Sub-57	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-187	Sub-58	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-188	Sub-59	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-189	Sub-82	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-190	Sub-83	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-191	Sub-61	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
3-192	Sub-55	3，4-diClPh	-CO-	Single bond	-CH2-cBu-
						3-193	Sub-33	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-194	Sub-34	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-195	Sub-35	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-196	Sub-36	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-197	Sub-37	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-198	Sub-38	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-199	Sub-39	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-200	Sub-40	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-201	Sub-41	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-202	Sub-42	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-203	Sub-84	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-204	Sub-43	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-205	Sub-44	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-206	Sub-45	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-207	Sub-46	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-208	Sub-47	3，4-diClPh	-CO-	Single bond	-CH2-cPn-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-209	Sub-81	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-210	Sub-48	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-211	Sub-49	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-212	Sub-50	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-213	Sub-51	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-214	Sub-52	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-215	Sub-53	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-216	Sub-54	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-217	Sub-56	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-218	Sub-57	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-219	Sub-58	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-220	Sub-59	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-221	Sub-82	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-222	Sub-83	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-223	Sub-61	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
3-224	Sub-55	3，4-diClPh	-CO-	Single bond	-CH2-cPn-
						3-225	Sub-33	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-226	Sub-34	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-227	Sub-35	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-228	Sub-36	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-229	Sub-37	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-230	Sub-38	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-231	Sub-39	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-232	Sub-40	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-233	Sub-41	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-234	Sub-42	3，4-diClPh	-CO-	Single bond	-CH2-cHx-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-235	Sub-84	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-236	Sub-43	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-237	Sub-44	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-238	Sub-45	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-239	Sub-46	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-240	Sub-47	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-241	Sub-81	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-242	Sub-48	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-243	Sub-49	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-244	Sub-50	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-245	Sub-51	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-246	Sub-52	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-247	Sub-53	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-248	Sub-54	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-249	Sub-56	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-250	Sub-57	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-251	Sub-58	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-252	Sub-59	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-253	Sub-82	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-254	Sub-83	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-255	Sub-61	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
3-256	Sub-55	3，4-diClPh	-CO-	Single bond	-CH2-cHx-
						3-257	Sub-33	4-ClPh	-CO-	Single bond	-CH2-
3-258	Sub-34	4-ClPh	-CO-	Single bond	-CH2-
						3-259	Sub-35	4-ClPh	-CO-	Single bond	-CH2-
3-260	Sub-36	4-ClPh	-CO-	Single bond	-CH2-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-261	Sub-37	4-ClPh	-CO-	Single bond	-CH2-
3-262	Sub-38	4-ClPh	-CO-	Single bond	-CH2-
						3-263	Sub-39	4-ClPh	-CO-	Single bond	-CH2-
3-264	Sub-40	4-ClPh	-CO-	Single bond	-CH2-
						3-265	Sub-41	4-ClPh	-CO-	Single bond	-CH2-
3-266	Sub-42	4-ClPh	-CO-	Single bond	-CH2-
						3-267	Sub-84	4-ClPh	-CO-	Single bond	-CH2-
3-268	Sub-43	4-ClPh	-CO-	Single bond	-CH2-
						3-269	Sub-44	4-ClPh	-CO-	Single bond	-CH2-
3-270	Sub-45	4-ClPh	-CO-	Single bond	-CH2-
						3-271	Sub-46	4-ClPh	-CO-	Single bond	-CH2-
3-272	Sub-47	4-ClPh	-CO-	Single bond	-CH2-
						3-273	Sub-81	4-ClPh	-CO-	Single bond	-CH2-
3-274	Sub-48	4-ClPh	-CO-	Single bond	-CH2-
						3-275	Sub-49	4-ClPh	-CO-	Single bond	-CH2-
3-276	Sub-50	4-ClPh	-CO-	Single bond	-CH2-
						3-277	Sub-51	4-ClPh	-CO-	Single bond	-CH2-
3-278	Sub-52	4-ClPh	-CO-	Single bond	-CH2-
						3-279	Sub-53	4-ClPh	-CO-	Single bond	-CH2-
3-280	Sub-54	4-ClPh	-CO-	Single bond	-CH2-
						3-281	Sub-56	4-ClPh	-CO-	Single bond	-CH2-
3-282	Sub-57	4-ClPh	-CO-	Single bond	-CH2-
						3-283	Sub-58	4-ClPh	-CO-	Single bond	-CH2-
3-284	Sub-59	4-ClPh	-CO-	Single bond	-CH2-
						3-285	Sub-82	4-ClPh	-CO-	Single bond	-CH2-
3-286	Sub-83	4-ClPh	-CO-	Single bond	-CH2-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-287	Sub-61	4-ClPh	-CO-	Single bond	-CH2-
3-288	Sub-55	4-ClPh	-CO-	Single bond	-CH2-
						3-289	Sub-33	4-ClPh	-CO-	Single bond	-CH2CH2-
3-290	Sub-34	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-291	Sub-35	4-ClPh	-CO-	Single bond	-CH2CH2-
3-292	Sub-36	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-293	Sub-37	4-ClPh	-CO-	Single bond	-CH2CH2-
3-294	Sub-38	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-295	Sub-39	4-ClPh	-CO-	Single bond	-CH2CH2-
3-296	Sub-40	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-297	Sub-41	4-ClPh	-CO-	Single bond	-CH2CH2-
3-298	Sub-42	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-299	Sub-84	4-ClPh	-CO-	Single bond	-CH2CH2-
3-300	Sub-43	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-301	Sub-44	4-ClPh	-CO-	Single bond	-CH2CH2-
3-302	Sub-45	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-303	Sub-46	4-ClPh	-CO-	Single bond	-CH2CH2-
3-304	Sub-47	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-305	Sub-81	4-ClPh	-CO-	Single bond	-CH2CH2-
3-306	Sub-48	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-307	Sub-49	4-ClPh	-CO-	Single bond	-CH2CH2-
3-308	Sub-50	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-309	Sub-51	4-ClPh	-CO-	Single bond	-CH2CH2-
3-310	Sub-52	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-311	Sub-53	4-ClPh	-CO-	Single bond	-CH2CH2-
3-312	Sub-54	4-ClPh	-CO-	Single bond	-CH2CH2-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-313	Sub-56	4-ClPh	-CO-	Single bond	-CH2CH2-
3-314	Sub-57	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-315	Sub-58	4-ClPh	-CO-	Single bond	-CH2CH2-
3-316	Sub-59	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-317	Sub-82	4-ClPh	-CO-	Single bond	-CH2CH2-
3-318	Sub-83	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-319	Sub-61	4-ClPh	-CO-	Single bond	-CH2CH2-
3-320	Sub-55	4-ClPh	-CO-	Single bond	-CH2CH2-
						3-321	Sub-33	4-ClPh	-CO-	Single bond	-(CH2)3-
3-322	Sub-34	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-323	Sub-35	4-ClPh	-CO-	Single bond	-(CH2)3-
3-324	Sub-36	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-325	Sub-37	4-ClPh	-CO-	Single bond	-(CH2)3-
3-326	Sub-38	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-327	Sub-39	4-ClPh	-CO-	Single bond	-(CH2)3-
3-328	Sub-40	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-329	Sub-41	4-ClPh	-CO-	Single bond	-(CH2)3-
3-330	Sub-42	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-331	Sub-84	4-ClPh	-CO-	Single bond	-(CH2)3-
3-332	Sub-43	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-333	Sub-44	4-ClPh	-CO-	Single bond	-(CH2)3-
3-334	Sub-45	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-335	Sub-46	4-ClPh	-CO-	Single bond	-(CH2)3-
3-336	Sub-47	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-337	Sub-81	4-ClPh	-CO-	Single bond	-(CH2)3-
3-338	Sub-48	4-ClPh	-CO-	Single bond	-(CH2)3-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-339	Sub-49	4-ClPh	-CO-	Single bond	-(CH2)3-
3-340	Sub-50	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-341	Sub-51	4-ClPh	-CO-	Single bond	-(CH2)3-
3-342	Sub-52	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-343	Sub-53	4-ClPh	-CO-	Single bond	-(CH2)3-
3-344	Sub-54	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-345	Sub-56	4-ClPh	-CO-	Single bond	-(CH2)3-
3-346	Sub-57	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-347	Sub-58	4-ClPh	-CO-	Single bond	-(CH2)3-
3-348	Sub-59	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-349	Sub-82	4-ClPh	-CO-	Single bond	-(CH2)3-
3-350	Sub-83	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-351	Sub-61	4-ClPh	-CO-	Single bond	-(CH2)3-
3-352	Sub-55	4-ClPh	-CO-	Single bond	-(CH2)3-
						3-353	Sub-33	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-354	Sub-34	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-355	Sub-35	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-356	Sub-36	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-357	Sub-37	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-358	Sub-38	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-359	Sub-39	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-360	Sub-40	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-361	Sub-41	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-362	Sub-42	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-363	Sub-84	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-364	Sub-43	4-ClPh	-CO-	Single bond	-CH2C(Me)2-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-365	Sub-44	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-366	Sub-45	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-367	Sub-46	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-368	Sub-47	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-369	Sub-81	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-370	Sub-48	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-371	Sub-49	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-372	Sub-50	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-373	Sub-51	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-374	Sub-52	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-375	Sub-53	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-376	Sub-54	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-377	Sub-56	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-378	Sub-57	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-379	Sub-58	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-380	Sub-59	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-381	Sub-82	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-382	Sub-83	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-383	Sub-61	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
3-384	Sub-55	4-ClPh	-CO-	Single bond	-CH2C(Me)2-
						3-385	Sub-33	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-386	Sub-34	4-ClPh	-CO-	Single bond	-CH2-cPr-
						3-387	Sub-35	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-388	Sub-36	4-ClPh	-CO-	Single bond	-CH2-cPr-
						3-389	Sub-37	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-390	Sub-38	4-ClPh	-CO-	Single bond	-CH2-cPr-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-391	Sub-39	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-392	Sub-40	4-ClPh	-CO-	Single bond	-CH2-cPr-
						3-393	Sub-41	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-394	Sub-42	4-ClPh	-CO-	Single bond	-CH2-cPr-
						3-395	Sub-84	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-396	Sub-43	4-ClPh	-CO-	Single bond	-CH2-cPr-
						3-397	Sub-44	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-398	Sub-45	4-ClPh	-CO-	Single bond	-CH2-cPr-
						3-399	Sub-46	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-400	Sub-47	4-ClPh	-CO-	Single bond	-CH2-cPr-
						3-401	Sub-81	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-402	Sub-48	4-ClPh	-CO-	Single bond	-CH2-cPr-
						3-403	Sub-49	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-404	Sub-50	4-ClPh	-CO-	Single bond	-CH2-cPr-
						3-405	Sub-51	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-406	Sub-52	4-ClPh	-CO-	Single bond	-CH2-cPr-
						3-407	Sub-53	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-408	Sub-54	4-ClPh	-CO-	Single bond	-CH2-cPr-
						3-409	Sub-56	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-410	Sub-57	4-ClPh	-CO-	Single bond	-CH2-cPr-
						3-411	Sub-58	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-412	Sub-59	4-ClPh	-CO-	Single bond	-CH2-cPr-
						3-413	Sub-82	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-414	Sub-83	4-ClPh	-CO-	Single bond	-CH2-cPr-
						3-415	Sub-61	4-ClPh	-CO-	Single bond	-CH2-cPr-
3-416	Sub-55	4-ClPh	-CO-	Single bond	-CH2-cPr-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-417	Sub-33	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-418	Sub-34	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-419	Sub-35	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-420	Sub-36	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-421	Sub-37	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-422	Sub-38	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-423	Sub-39	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-424	Sub-40	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-425	Sub-41	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-426	Sub-42	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-427	Sub-84	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-428	Sub-43	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-429	Sub-44	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-430	Sub-45	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-431	Sub-46	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-432	Sub-47	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-433	Sub-81	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-434	Sub-48	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-435	Sub-49	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-436	Sub-50	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-437	Sub-51	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-438	Sub-52	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-439	Sub-53	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-440	Sub-54	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-441	Sub-56	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-442	Sub-57	4-ClPh	-CO-	Single bond	-CH2-cBu-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-443	Sub-58	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-444	Sub-59	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-445	Sub-82	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-446	Sub-83	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-447	Sub-61	4-ClPh	-CO-	Single bond	-CH2-cBu-
3-448	Sub-55	4-ClPh	-CO-	Single bond	-CH2-cBu-
						3-449	Sub-33	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-450	Sub-34	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-451	Sub-35	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-452	Sub-36	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-453	Sub-37	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-454	Sub-38	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-455	Sub-39	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-456	Sub-40	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-457	Sub-41	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-458	Sub-42	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-459	Sub-84	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-460	Sub-43	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-461	Sub-44	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-462	Sub-45	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-463	Sub-46	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-464	Sub-47	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-465	Sub-81	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-466	Sub-48	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-467	Sub-49	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-468	Sub-50	4-ClPh	-CO-	Single bond	-CH2-cPn-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-469	Sub-51	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-470	Sub-52	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-471	Sub-53	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-472	Sub-54	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-473	Sub-56	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-474	Sub-57	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-475	Sub-58	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-476	Sub-59	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-477	Sub-82	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-478	Sub-83	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-479	Sub-61	4-ClPh	-CO-	Single bond	-CH2-cPn-
3-480	Sub-55	4-ClPh	-CO-	Single bond	-CH2-cPn-
						3-481	Sub-33	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-482	Sub-34	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-483	Sub-35	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-484	Sub-36	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-485	Sub-37	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-486	Sub-38	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-487	Sub-39	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-488	Sub-40	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-489	Sub-41	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-490	Sub-42	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-491	Sub-84	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-492	Sub-43	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-493	Sub-44	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-494	Sub-45	4-ClPh	-CO-	Single bond	-CH2-cHx-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-495	Sub-46	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-496	Sub-47	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-497	Sub-81	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-498	Sub-48	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-499	Sub-49	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-500	Sub-50	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-501	Sub-51	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-502	Sub-52	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-503	Sub-53	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-504	Sub-54	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-505	Sub-56	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-506	Sub-57	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-507	Sub-58	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-508	Sub-59	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-509	Sub-82	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-510	Sub-83	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-511	Sub-61	4-ClPh	-CO-	Single bond	-CH2-cHx-
3-512	Sub-55	4-ClPh	-CO-	Single bond	-CH2-cHx-
						3-513	Sub-33	4-FPh	-CO-	Single bond	-CH2-
3-514	Sub-34	4-FPh	-CO-	Single bond	-CH2-
						3-515	Sub-35	4-FPh	-CO-	Single bond	-CH2-
3-516	Sub-36	4-FPh	-CO-	Single bond	-CH2-
						3-517	Sub-37	4-FPh	-CO-	Single bond	-CH2-
3-518	Sub-38	4-FPh	-CO-	Single bond	-CH2-
						3-519	Sub-39	4-FPh	-CO-	Single bond	-CH2-
3-520	Sub-40	4-FPh	-CO-	Single bond	-CH2-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-521	Sub-41	4-FPh	-CO-	Single bond	-CH2-
3-522	Sub-42	4-FPh	-CO-	Single bond	-CH2-
						3-523	Sub-84	4-FPh	-CO-	Single bond	-CH2-
3-524	Sub-43	4-FPh	-CO-	Single bond	-CH2-
						3-525	Sub-44	4-FPh	-CO-	Single bond	-CH2-
3-526	Sub-45	4-FPh	-CO-	Single bond	-CH2-
						3-527	SuB-46	4-FPh	-CO-	Single bond	-CH2-
3-528	Sub-47	4-FPh	-CO-	Single bond	-CH2-
						3-529	Sub-81	4-FPh	-CO-	Single bond	-CH2-
3-530	Sub-48	4-FPh	-CO-	Single bond	-CH2-
						3-531	Sub-49	4-FPh	-CO-	Single bond	-CH2-
3-532	Sub-50	4-FPh	-CO-	Single bond	-CH2-
						3-533	Sub-51	4-FPh	-CO-	Single bond	-CH2-
3-534	Sub-52	4-FPh	-CO-	Single bond	-CH2-
						3-535	Sub-53	4-FPh	-CO-	Single bond	-CH2-
3-536	Sub-54	4-FPh	-CO-	Single bond	-CH2-
						3-537	Sub-56	4-FPh	-CO-	Single bond	-CH2-
3-538	Sub-57	4-FPh	-CO-	Single bond	-CH2-
						3-539	Sub-58	4-FPh	-CO-	Single bond	-CH2-
3-540	Sub-59	4-FPh	-CO-	Single bond	-CH2-
						3-541	Sub-82	4-FPh	-CO-	Single bond	-CH2-
3-542	Sub-83	4-FPh	-CO-	Single bond	-CH2-
						3-543	Sub-61	4-FPh	-CO-	Single bond	-CH2-
3-544	Sub-55	4-FPh	-CO-	Single bond	-CH2-
						3-545	Sub-33	4-FPh	-CO-	Single bond	-CH2CH2-
3-546	Sub-34	4-FPh	-CO-	Single bond	-CH2CH2-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-547	Sub-35	4-FPh	-CO-	Single bond	-CH2CH2-
3-548	Sub-36	4-FPh	-CO-	Single bond	-CH2CH2-
						3-549	Sub-37	4-FPh	-CO-	Single bond	-CH2CH2-
3-550	Sub-38	4-FPh	-CO-	Single bond	-CH2CH2-
						3-551	Sub-39	4-FPh	-CO-	Single bond	-CH2CH2-
3-552	Sub-40	4-FPh	-CO-	Single bond	-CH2CH2-
						3-553	Sub-41	4-FPh	-CO-	Single bond	-CH2CH2-
3-554	Sub-42	4-FPh	-CO-	Single bond	-CH2CH2-
						3-555	Sub-84	4-FPh	-CO-	Single bond	-CH2CH2-
3-556	Sub-43	4-FPh	-CO-	Single bond	-CH2CH2-
						3-557	Sub-44	4-FPh	-CO-	Single bond	-CH2CH2-
3-558	Sub-45	4-FPh	-CO-	Single bond	-CH2CH2-
						3-559	Sub-46	4-FPh	-CO-	Single bond	-CH2CH2-
3-560	Sub-47	4-FPh	-CO-	Single bond	-CH2CH2-
						3-561	Sub-81	4-FPh	-CO-	Single bond	-CH2CH2-
3-562	Sub-48	4-FPh	-CO-	Single bond	-CH2CH2-
						3-563	Sub-49	4-FPh	-CO-	Single bond	-CH2CH2-
3-564	Sub-50	4-FPh	-CO-	Single bond	-CH2CH2-
						3-565	Sub-51	4-FPh	-CO-	Single bond	-CH2CH2-
3-566	Sub-52	4-FPh	-CO-	Single bond	-CH2CH2-
						3-567	Sub-53	4-FPh	-CO-	Single bond	-CH2CH2-
3-568	Sub-54	4-FPh	-CO-	Single bond	-CH2CH2-
						3-569	Sub-56	4-FPh	-CO-	Single bond	-CH2CH2-
3-570	Sub-57	4-FPh	-CO-	Single bond	-CH2CH2-
						3-571	Sub-58	4-FPh	-CO-	Single bond	-CH2CH2-
3-572	Sub-59	4-FPh	-CO-	Single bond	-CH2CH2-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-573	Sub-82	4-FPh	-CO-	Single bond	-CH2CH2-
3-574	Sub-83	4-FPh	-CO-	Single bond	-CH2CH2-
						3-575	Sub-61	4-FPh	-CO-	Single bond	-CH2CH2-
3-576	Sub-55	4-FPh	-CO-	Single bond	-CH2CH2-
						3-577	Sub-33	4-FPh	-CO-	Single bond	-(CH2)3-
3-578	Sub-34	4-FPh	-CO-	Single bond	-(CH2)3-
						3-579	Sub-35	4-FPh	-CO-	Single bond	-(CH2)3-
3-580	Sub-36	4-FPh	-CO-	Single bond	-(CH2)3-
						3-581	Sub-37	4-FPh	-CO-	Single bond	-(CH2)3-
3-582	Sub-38	4-FPh	-CO-	Single bond	-(CH2)3-
						3-583	Sub-39	4-FPh	-CO-	Single bond	-(CH2)3-
3-584	Sub-40	4-FPh	-CO-	Single bond	-(CH2)3-
						3-585	Sub-41	4-FPh	-CO-	Single bond	-(CH2)3-
3-586	Sub-42	4-FPh	-CO-	Single bond	-(CH2)3-
						3-587	Sub-84	4-FPh	-CO-	Single bond	-(CH2)3-
3-588	Sub-43	4-FPh	-CO-	Single bond	-(CH2)3-
						3-589	Sub-44	4-FPh	-CO-	Single bond	-(CH2)3-
3-590	Sub-45	4-FPh	-CO-	Single bond	-(CH2)3-
						3-591	Sub-46	4-FPh	-CO-	Single bond	-(CH2)3-
3-592	Sub-47	4-FPh	-CO-	Single bond	-(CH2)3-
						3-593	Sub-81	4-FPh	-CO-	Single bond	-(CH2)3-
3-594	Sub-48	4-FPh	-CO-	Single bond	-(CH2)3-
						3-595	Sub-49	4-FPh	-CO-	Single bond	-(CH2)3-
3-596	Sub-50	4-FPh	-CO-	Single bond	-(CH2)3-
						3-597	Sub-51	4-FPh	-CO-	Single bond	-(CH2)3-
3-598	Sub-52	4-FPh	-CO-	Single bond	-(CH2)3-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-599	Sub-53	4-FPh	-CO-	Single bond	-(CH2)3-
3-600	Sub-54	4-FPh	-CO-	Single bond	-(CH2)3-
						3-601	Sub-56	4-FPh	-CO-	Single bond	-(CH2)3-
3-602	Sub-57	4-FPh	-CO-	Single bond	-(CH2)3-
						3-603	Sub-58	4-FPh	-CO-	Single bond	-(CH2)3-
3-604	Sub-59	4-FPh	-CO-	Single bond	-(CH2)3-
						3-605	Sub-82	4-FPh	-CO-	Single bond	-(CH2)3-
3-606	Sub-83	4-FPh	-CO-	Single bond	-(CH2)3-
						3-607	Sub-61	4-FPh	-CO-	Single bond	-(CH2)3-
3-608	Sub-55	4-FPh	-CO-	Single bond	-(CH2)3-
						3-609	Sub-33	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-610	Sub-34	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-611	Sub-35	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-612	Sub-36	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-613	Sub-37	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-614	Sub-38	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-615	Sub-39	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-616	Sub-40	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-617	Sub-41	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-618	Sub-42	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-619	Sub-84	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-620	Sub-43	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-621	Sub-44	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-622	Sub-45	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-623	Sub-46	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-624	Sub-47	4-FPh	-CO-	Single bond	-CH2C(Me)2-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-625	Sub-81	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-626	Sub-48	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-627	Sub-49	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-628	Sub-50	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-629	Sub-51	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-630	Sub-52	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-631	Sub-53	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-632	Sub-54	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-633	Sub-56	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-634	Sub-57	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-635	Sub-58	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-636	Sub-59	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-637	Sub-82	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-638	Sub-83	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-639	Sub-61	4-FPh	-CO-	Single bond	-CH2C(Me)2-
3-640	Sub-55	4-FPh	-CO-	Single bond	-CH2C(Me)2-
						3-641	Sub-33	4-FPh	-CO-	Single bond	-CH2-cPr-
3-642	Sub-34	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-643	Sub-35	4-FPh	-CO-	Single bond	-CH2-cPr-
3-644	Sub-36	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-645	Sub-37	4-FPh	-CO-	Single bond	-CH2-cPr-
3-646	Sub-38	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-647	Sub-39	4-FPh	-CO-	Single bond	-CH2-cPr-
3-648	Sub-40	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-649	Sub-41	4-FPh	-CO-	Single bond	-CH2-cPr-
3-650	Sub-42	4-FPh	-CO-	Single bond	-CH2-cPr-

Table 3(cont.)

Compound (I) Serial number	R1	R2	A	B	E
						3-651	Sub-84	4-FPh	-CO-	Single bond	-CH2-cPr-
3-652	Sub-43	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-653	Sub-44	4-FPh	-CO-	Single bond	-CH2-cPr-
3-654	Sub-45	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-655	Sub-46	4-FPh	-CO-	Single bond	-CH2-cPr-
3-656	Sub-47	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-657	Sub-81	4-FPh	-CO-	Single bond	-CH2-cPr-
3-658	Sub-48	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-659	Sub-49	4-FPh	-CO-	Single bond	-CH2-cPr-
3-660	Sub-50	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-661	Sub-51	4-FPh	-CO-	Single bond	-CH2-cPr-
3-662	Sub-52	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-663	Sub-53	4-FPh	-CO-	Single bond	-CH2-cPr-
3-664	Sub-54	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-665	Sub-56	4-FPh	-CO-	Single bond	-CH2-cPr-
3-666	Sub-57	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-667	Sub-58	4-FPh	-CO-	Single bond	-CH2-cPr-
3-668	Sub-59	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-669	Sub-82	4-FPh	-CO-	Single bond	-CH2-cPr-
3-670	Sub-83	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-671	Sub-61	4-FPh	-CO-	Single bond	-CH2-cPr-
3-672	Sub-55	4-FPh	-CO-	Single bond	-CH2-cPr-
						3-673	Sub-33	4-FPh	-CO-	Single bond	-CH2-cBu-
3-674	Sub-34	4-FPh	-CO-	Single bond	-CH2-cBu-
						3-675	Sub-35	4-FPh	-CO-	Single bond	-CH2-cBu-
3-676	Sub-36	4-FPh	-CO-	Single bond	-CH2-cBu-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-677	Sub-37	4-FPh	-CO-	Single bond	-CH2-cBu-
3-678	Sub-38	4-FPh	-CO-	Single bond	-CH2-cBu-
						3-679	Sub-39	4-FPh	-CO-	Single bond	-CH2-cBu-
3-680	Sub-40	4-FPh	-CO-	Single bond	-CH2-cBu-
						3-681	Sub-41	4-FPh	-CO-	Single bond	-CH2-cBu-
3-682	Sub-42	4-FPh	-CO-	Single bond	-CH2-cBu-
						3-683	Sub-84	4-FPh	-CO-	Single bond	-CH2-cBu-
3-684	Sub-43	4-FPh	-CO-	Single bond	-CH2-cBu-
						3-685	Sub-44	4-FPh	-CO-	Single bond	-CH2-cBu-
3-686	Sub-45	4-FPh	-CO-	Single bond	-CH2-cBu-
						3-687	Sub-46	4-FPh	-CO-	Single bond	-CH2-cBu-
3-688	Sub-47	4-FPh	-CO-	Single bond	-CH2-cBu-
						3-689	Sub-81	4-FPh	-CO-	Single bond	-CH2-cBu-
3-690	Sub-48	4-FPh	-CO-	Single bond	-CH2-cBu-
						3-691	Sub-49	4-FPh	-CO-	Single bond	-CH2-cBu-
3-692	Sub-50	4-FPh	-CO-	Single bond	-CH2-cBu-
						3-693	Sub-51	4-FPh	-CO-	Single bond	-CH2-cBu-
3-694	Sub-52	4-FPh	-CO-	Single bond	-CH2-cBu-
						3-695	Sub-53	4-FPh	-CO-	Single bond	-CH2-cBu-
3-696	Sub-54	4-FPh	-CO-	Single bond	-CH2-cBu-
						3-697	Sub-56	4-FPh	-CO-	Single bond	-CH2-cBu-
3-698	Sub-57	4-FPh	-CO-	Single bond	-CH2-cBu-
						3-699	Sub-58	4-FPh	-CO-	Single bond	-CH2-cBu-
3-700	Sub-59	4-FPh	-CO-	Single bond	-CH2-cBu-
						3-701	Sub-82	4-FPh	-CO-	Single bond	-CH2-cBu-
3-702	Sub-83	4-FPh	-CO-	Single bond	-CH2-cBu-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-703	Sub-61	4-FPh	-CO-	Single bond	-CH2-cBu-
3-704	Sub-55	4-FPh	-CO-	Single bond	-CH2-cBu-
						3-705	Sub-33	4-FPh	-CO-	Single bond	-CH2-cPn-
3-706	Sub-34	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-707	Sub-35	4-FPh	-CO-	Single bond	-CH2-cPn-
3-708	Sub-36	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-709	Sub-37	4-FPh	-CO-	Single bond	-CH2-cPn-
3-710	Sub-38	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-711	Sub-39	4-FPh	-CO-	Single bond	-CH2-cPn-
3-712	Sub-40	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-713	Sub-41	4-FPh	-CO-	Single bond	-CH2-cPn-
3-714	Sub-42	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-715	Sub-84	4-FPh	-CO-	Single bond	-CH2-cPn-
3-716	Sub-43	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-717	Sub-44	4-FPh	-CO-	Single bond	-CH2-cPn-
3-718	Sub-45	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-719	Sub-46	4-FPh	-CO-	Single bond	-CH2-cPn-
3-720	Sub-47	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-721	Sub-81	4-FPh	-CO-	Single bond	-CH2-cPn-
3-722	Sub-48	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-723	Sub-49	4-FPh	-CO-	Single bond	-CH2-cPn-
3-724	Sub-50	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-725	Sub-51	4-FPh	-CO-	Single bond	-CH2-cPn-
3-726	Sub-52	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-727	Sub-53	4-FPh	-CO-	Single bond	-CH2-cPn-
3-728	Sub-54	4-FPh	-CO-	Single bond	-CH2-cPn-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-729	Sub-56	4-FPh	-CO-	Single bond	-CH2-cPn-
3-730	Sub-57	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-731	Sub-58	4-FPh	-CO-	Single bond	-CH2-cPn-
3-732	Sub-59	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-733	Sub-82	4-FPh	-CO-	Single bond	-CH2-cPn-
3-734	Sub-83	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-735	Sub-61	4-FPh	-CO-	Single bond	-CH2-cPn-
3-736	Sub-55	4-FPh	-CO-	Single bond	-CH2-cPn-
						3-737	Sub-33	4-FPh	-CO-	Single bond	-CH2-cHx-
3-738	Sub-34	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-739	Sub-35	4-FPh	-CO-	Single bond	-CH2-cHx-
3-740	Sub-36	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-741	Sub-37	4-FPh	-CO-	Single bond	-CH2-cHx-
3-742	Sub-38	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-743	Sub-39	4-FPh	-CO-	Single bond	-CH2-cHx-
3-744	Sub-40	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-745	Sub-41	4-FPh	-CO-	Single bond	-CH2-cHx-
3-746	Sub-42	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-747	Sub-84	4-FPh	-CO-	Single bond	-CH2-cHx-
3-748	Sub-43	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-749	Sub-44	4-FPh	-CO-	Single bond	-CH2-cHx-
3-750	Sub-45	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-751	Sub-46	4-FPh	-CO-	Single bond	-CH2-cHx-
3-752	Sub-47	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-753	Sub-81	4-FPh	-CO-	Single bond	-CH2-cHx-
3-754	Sub-48	4-FPh	-CO-	Single bond	-CH2-cHx-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-755	Sub-49	4-FPh	-CO-	Single bond	-CH2-cHx-
3-756	Sub-50	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-757	Sub-51	4-FPh	-CO-	Single bond	-CH2-cHx-
3-758	Sub-52	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-759	Sub-53	4-FPh	-CO-	Single bond	-CH2-cHx-
3-760	Sub-54	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-761	Sub-56	4-FPh	-CO-	Single bond	-CH2-cHx-
3-762	Sub-57	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-763	Sub-58	4-FPh	-CO-	Single bond	-CH2-cHx-
3-764	Sub-59	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-765	Sub-82	4-FPh	-CO-	Single bond	-CH2-cHx-
3-766	Sub-83	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-767	Sub-61	4-FPh	-CO-	Single bond	-CH2-cHx-
3-768	Sub-55	4-FPh	-CO-	Single bond	-CH2-cHx-
						3-769	Sub-33	3，4-diClPh	-CO-	-CH2-	-CH2-
3-770	Sub-34	3，4-diClPh	-CO-	-CH2-	-CH2-
						3-771	Sub-35	3，4-dClPh	-CO-	-CH2-	-CH2-
3-772	Sub-36	3，4-diClPh	-CO-	-CH2-	-CH2-
						3-773	Sub-37	3，4-diClPh	-CO-	-CH2-	-CH2-
3-774	Sub-38	3，4-diClPh	-CO-	-CH2-	-CH2-
						3-775	Sub-39	3-4-diClPh	-CO-	-CH2-	-CH2-
3-776	Sub-40	3，4-diClPh	-CO-	-CH2-	-CH2-
						3-777	Sub-41	3，4-diClPh	-CO-	-CH2-	-CH2-
3-778	Sub-42	3，4-diClPh	-CO-	-CH2-	-CH2-
						3-779	Sub-84	3，4-diClPh	-CO-	-CH2-	-CH2-
3-780	Sub-43	3，4-diClPh	-CO-	-CH2-	-CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-781	Sub-44	3，4-diClPh	-CO-	-CH2-	-CH2-
3-782	Sub-45	3，4-diClPh	-CO-	-CH2-	-CH2-
						3-783	Sub-46	3，4-diClPh	-CO-	-CH2-	-CH2-
3-784	Sub-47	3，4-diClPh	-CO-	-CH2-	-CH2-
						3-785	Sub-81	3，4-diClPh	-CO-	-CH2-	-CH2-
3-786	Sub-48	3，4-diClPh	-CO-	-CH2-	-CH2-
						3-787	Sub-49	3，4-diClPh	-CO-	-CH2-	-CH2-
3-788	Sub-50	3，4-diClPh	-CO-	-CH2-	-CH2-
						3-789	Sub-51	3，4-diClPh	-CO-	-CH2-	-CH2-
3-790	Sub-52	3，4-diClPh	-CO-	-CH2-	-CH2-
						3-791	Sub-53	3，4-diClPh	-CO-	-CH2-	-CH2-
3-792	Sub-54	3，4-diCPh	-CO-	-CH2-	-CH2-
						3-793	Sub-56	3，4-diClPh	-CO-	-CH2-	-CH2-
3-794	Sub-57	3，4-diClPh	-CO-	-CH2-	-CH2-
						3-795	Sub-58	3，4-diClPh	-CO-	-CH2-	-CH2-
3-796	Sub-59	3，4-diClPh	-CO-	-CH2-	-CH2-
						3-797	Sub-82	3，4-diClPh	-CO-	-CH2-	-CH2-
3-798	Sub-83	3，4-diClPh	-CO-	-CH2-	-CH2-
						3-799	Sub-61	3，4-diClPh	-CO-	-CH2-	-CH2-
3-800	Sub-55	3，4-diClPh	-CO-	-CH2-	-CH2-
						3-801	Sub-33	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-802	Sub-34	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
						3-803	Sub-35	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-804	Sub-36	3，4-diCHph	-CO-	-CH2-	-CH2CH2-
						3-805	Sub-37	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-806	Sub-38	3，4-diClPh	-CO-	-CH2-	-CH2CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-807	Sub-39	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-808	Sub-40	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
						3-809	Sub-41	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-810	Sub-42	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
						3-811	Sub-84	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-812	Sub-43	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
						3-813	Sub-44	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-814	Sub-45	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
						3-815	Sub-46	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-816	Sub-47	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
						3-817	Sub-81	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-818	Sub-48	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
						3-819	Sub-49	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-820	Sub-50	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
						3-821	Sub-51	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-822	Sub-52	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
						3-823	Sub-53	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-824	Sub-54	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
						3-825	Sub-56	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-826	Sub-57	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
						3-827	Sub-58	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-828	Sub-59	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
						3-829	Sub-82	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-830	Sub-83	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
						3-831	Sub-61	3，4-diClPh	-CO-	-CH2-	-CH2CH2-
3-832	Sub-55	3，4-diClPh	-CO-	-CH2-	-CH2CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-833	Sub-33	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-834	Sub-34	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-835	Sub-35	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-836	Sub-36	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-837	Sub-37	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-838	Sub-38	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-839	Sub-39	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-840	Sub-40	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-841	Sub-41	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-842	Sub-42	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-843	Sub-84	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-844	Sub-43	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-845	Sub-44	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-846	Sub-45	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-847	Sub-46	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-848	Sub-47	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-849	Sub-81	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-850	Sub-48	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-851	Sub-49	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-852	Sub-50	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-853	Sub-51	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-854	Sub-52	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-855	Sub-53	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-856	Sub-54	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-857	Sub-56	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-858	Sub-57	3，4-diClPh	-CO-	-CH2-	-(CH2)3-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-859	Sub-58	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-860	Sub-59	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-861	Sub-82	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-862	Sub-83	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-863	Sub-61	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
3-864	Sub-55	3，4-diClPh	-CO-	-CH2-	-(CH2)3-
						3-865	Sub-33	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-866	Sub-34	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-867	Sub-35	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-868	Sub-36	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-869	Sub-37	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-870	Sub-38	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-871	Sub-39	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-872	Sub-40	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-873	Sub-41	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-874	Sub-42	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-875	Sub-84	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-876	Sub-43	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-877	Sub-44	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-878	Sub-45	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-879	Sub-46	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-880	Sub-47	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-881	Sub-81	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-882	Sub-48	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-883	Sub-49	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-884	Sub-50	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-

TABLE 3 (cont)

Compound (I) A serial number.	R1	R2	A	B	E
						3-885	Sub-51	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-886	Sub-52	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-887	Sub-53	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-888	Sub-54	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-889	Sub-56	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-890	Sub-57	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-891	Sub-58	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-892	Sub-59	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-893	Sub-82	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-894	Sub-83	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-895	Sub-61	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
3-896	Sub-55	3，4-diClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-897	Sub-33	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-898	Sub-34	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-899	Sub-35	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-900	Sub-36	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-901	Sub-37	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-902	Sub-38	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-903	Sub-39	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-904	Sub-40	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-905	Sub-41	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-906	Sub-42	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-907	Sub-84	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-908	Sub-43	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-909	Sub-44	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-910	Sub-45	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-911	Sub-46	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-912	Sub-47	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-913	Sub-81	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-914	Sub-48	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-915	Sub-49	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-916	Sub-50	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-917	Sub-51	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-918	Sub-52	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-919	Sub-53	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-920	Sub-54	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-921	Sub-56	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-922	Sub-57	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-923	Sub-58	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-924	Sub-59	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-925	Sub-82	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-926	Sub-83	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-927	Sub-61	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
3-928	Sub-55	3，4-diClPh	-CO-	-CH2-	-CH2-cPr-
						3-929	Sub-33	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-930	Sub-34	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-931	Sub-35	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-932	Sub-36	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-933	Sub-37	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-934	Sub-38	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-935	Sub-39	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-936	Sub-40	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-937	Sub-41	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-938	Sub-42	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-939	Sub-84	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-940	Sub-43	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-941	Sub-44	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-942	Sub-45	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-943	Sub-46	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-944	Sub-47	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-945	Sub-81	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-946	Sub-48	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-947	Sub-49	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-948	Sub-50	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-949	Sub-51	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-950	Sub-52	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-951	Sub-53	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-952	Sub-54	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-953	Sub-56	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-954	Sub-57	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-955	Sub-58	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-956	Sub-59	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-957	Sub-82	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-958	Sub-83	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-959	Sub-61	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
3-960	Sub-55	3，4-diClPh	-CO-	-CH2-	-CH2-cBu-
						3-961	Sub-33	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-962	Sub-34	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-963	Sub-35	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-964	Sub-36	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
						3-965	Sub-37	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-966	Sub-38	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
						3-967	Sub-39	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-968	Sub-40	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
						3-969	Sub-41	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-970	Sub-42	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
						3-971	Sub-84	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-972	Sub-43	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
						3-973	Sub-44	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-974	Sub-45	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
						3-975	Sub-46	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-976	Sub-47	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
						3-977	Sub-81	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-978	Sub-48	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
						3-979	Sub-49	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-980	Sub-50	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
						3-981	Sub-51	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-982	Sub-52	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
						3-983	Sub-53	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-984	Sub-54	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
						3-985	Sub-56	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-986	Sub-57	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
						3-987	Sub-58	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-988	Sub-59	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-989	Sub-82	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-990	Sub-83	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
						3-991	Sub-61	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
3-992	Sub-55	3，4-diClPh	-CO-	-CH2-	-CH2-cPn-
						3-993	Sub-33	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-994	Sub-34	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-995	Sub-35	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-996	Sub-36	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-997	Sub-37	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-998	Sub-38	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-999	Sub-39	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-1000	Sub-40	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-1001	Sub-41	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-1002	Sub-42	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-1003	Sub-84	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-1004	Sub-43	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-1005	Sub-44	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-1006	Sub-45	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-1007	Sub-46	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-1008	Sub-47	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-1009	Sub-81	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-1010	Sub-48	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-1011	Sub-49	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-1012	Sub-50	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-1013	Sub-51	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-1014	Sub-52	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1015	Sub-53	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-1016	Sub-54	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-1017	Sub-56	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-1018	Sub-57	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-1019	Sub-58	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-1020	Sub-59	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-1021	Sub-82	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-1022	Sub-83	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-1023	Sub-61	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
3-1024	Sub-55	3，4-diClPh	-CO-	-CH2-	-CH2-cHx-
						3-1025	Sub-33	4-ClPh	-CO-	-CH2-	-CH2-
3-1026	Sub-34	4-ClPh	-CO-	-CH2-	-CH2-
						3-1027	Sub-35	4-ClPh	-CO-	-CH2-	-CH2-
3-1028	Sub-36	4-ClPh	-CO-	-CH2-	-CH2-
						3-1029	Sub-37	4-ClPh	-CO-	-CH2-	-CH2-
3-1030	Sub-38	4-ClPh	-CO-	-CH2-	-CH2-
						3-1031	Sub-39	4-ClPh	-CO-	-CH2-	-CH2-
3-1032	Sub-40	4-ClPh	-CO-	-CH2-	-CH2-
						3-1033	Sub-41	4-ClPh	-CO-	-CH2-	-CH2-
3-1034	Sub-42	4-ClPh	-CO-	-CH2-	-CH2-
						3-1035	Sub-84	4-ClPh	-CO-	-CH2-	-CH2-
3-1036	Sub-43	4-ClPh	-CO-	-CH2-	-CH2-
						3-1037	Sub-44	4-ClPh	-CO-	-CH2-	-CH2-
3-1038	Sub-45	4-ClPh	-CO-	-CH2-	-CH2-
						3-1039	Sub-46	4-ClPh	-CO-	-CH2-	-CH2-
3-1040	Sub-47	4-ClPh	-CO-	-CH2-	-CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1041	Sub-81	4-ClPh	-CO-	-CH2-	-CH2-
3-1042	Sub-48	4-ClPh	-CO-	-CH2-	-CH2-
						3-1043	Sub-49	4-ClPh	-CO-	-CH2-	-CH2-
3-1044	Sub-50	4-ClPh	-CO-	-CH2-	-CH2-
						3-1045	Sub-51	4-ClPh	-CO-	-CH2-	-CH2-
3-1046	Sub-52	4-ClPh	-CO-	-CH2-	-CH2-
						3-1047	Sub-53	4-ClPh	-CO-	-CH2-	-CH2-
3-1048	Sub-54	4-ClPh	-CO-	-CH2-	-CH2-
						3-1049	Sub-56	4-ClPh	-CO-	-CH2-	-CH2-
3-1050	Sub-57	4-ClPh	-CO-	-CH2-	-CH2-
						3-1051	Sub-58	4-ClPh	-CO-	-CH2-	-CH2-
3-1052	Sub-59	4-ClPh	-CO-	-CH2-	-CH2-
						3-1053	Sub-82	4-ClPh	-CO-	-CH2-	-CH2-
3-1054	Sub-83	4-ClPh	-CO-	-CH2-	-CH2-
						3-1055	Sub-61	4-ClPh	-CO-	-CH2-	-CH2-
3-1056	Sub-55	4-ClPh	-CO-	-CH2-	-CH2-
						3-1057	Sub-33	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1058	Sub-34	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1059	Sub-35	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1060	Sub-36	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1061	Sub-37	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1062	Sub-38	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1063	Sub-39	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1064	Sub-40	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1065	Sub-41	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1066	Sub-42	4-ClPh	-CO-	-CH2-	-CH2CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1067	Sub-84	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1068	Sub-43	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1069	Sub-44	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1070	Sub-45	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1071	Sub-46	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1072	Sub-47	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1073	Sub-81	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1074	Sub-48	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1075	Sub-49	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1076	Sub-50	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1077	Sub-51	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1078	Sub-52	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1079	Sub-53	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1080	Sub-54	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1081	Sub-56	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1082	Sub-57	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1083	Sub-58	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1084	Sub-59	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1085	Sub-82	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1086	Sub-83	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1087	Sub-61	4-ClPh	-CO-	-CH2-	-CH2CH2-
3-1088	Sub-55	4-ClPh	-CO-	-CH2-	-CH2CH2-
						3-1089	Sub-33	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1090	Sub-34	4-ClPh	-CO-	-CH2-	-(CH2)3-
						3-1091	Sub-35	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1092	Sub-36	4-ClPh	-CO-	-CH2-	-(CH2)3-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1093	Sub-37	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1094	Sub-38	4-ClPh	-CO-	-CH2-	-(CH2)3-
						3-1095	Sub-39	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1096	Sub-40	4-ClPh	-CO-	-CH2-	-(CH2)3-
						3-1097	Sub-41	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1098	Sub-42	4-ClPh	-CO-	-CH2-	-(CH2)3-
						3-1099	Sub-84	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1100	Sub-43	4-ClPh	-CO-	-CH2-	-(CH2)3-
						3-1101	Sub-44	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1102	Sub-45	4-ClPh	-CO-	-CH2-	-(CH2)3-
						3-1103	Sub-46	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1104	Sub-47	4-ClPh	-CO-	-CH2-	-(CH2)3-
						3-1105	Sub-81	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1106	Sub-48	4-ClPh	-CO-	-CH2-	-(CH2)3-
						3-1107	Sub-49	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1108	Sub-50	4-ClPh	-CO-	-CH2-	-(CH2)3-
						3-1109	Sub-51	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1110	Sub-52	4-ClPh	-CO-	-CH2-	-(CH2)3-
						3-1111	Sub-53	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1112	Sub-54	4-ClPh	-CO-	-CH2-	-(CH2)3-
						3-1113	Sub-56	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1114	Sub-57	4-ClPh	-CO-	-CH2-	-(CH2)3-
						3-1115	Sub-58	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1116	Sub-59	4-ClPh	-CO-	-CH2-	-(CH2)3-
						3-1117	Sub-82	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1118	Sub-83	4-ClPh	-CO-	-CH2-	-(CH2)3-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1119	Sub-61	4-ClPh	-CO-	-CH2-	-(CH2)3-
3-1120	Sub-55	4-ClPh	-CO-	-CH2-	-(CH2)3-
						3-1121	Sub-33	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1122	Sub-34	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1123	Sub-35	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1124	Sub-36	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1125	Sub-37	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1126	Sub-38	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1127	Sub-39	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1128	Sub-40	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1129	Sub-41	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1130	Sub-42	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1131	Sub-84	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1132	Sub-43	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1133	Sub-44	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1134	Sub-45	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1135	Sub-46	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1136	Sub-47	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1137	Sub-81	4-C lPh	-CO-	-CH2-	-CH2C(Me)2-
3-1138	Sub-48	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1139	Sub-49	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1140	Sub-50	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1141	Sub-51	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1142	Sub-52	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1143	Sub-53	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1144	Sub-54	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1145	Sub-56	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1146	Sub-57	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1147	Sub-58	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1148	Sub-59	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1149	Sub-82	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1150	Sub-83	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1151	Sub-61	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
3-1152	Sub-55	4-ClPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1153	Sub-33	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1154	Sub-34	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1155	Sub-35	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1156	Sub-36	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1157	Sub-37	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1158	Sub-38	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1159	Sub-39	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1160	Sub-40	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1161	Sub-41	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1162	Sub-42	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1163	Sub-84	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1164	Sub-43	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1165	Sub-44	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1166	Sub-45	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1167	Sub-46	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1168	Sub-47	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1169	Sub-81	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1170	Sub-48	4-ClPh	-CO-	-CH2-	-CH2-cPr-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1171	Sub-49	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1172	Sub-50	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1173	Sub-51	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1174	Sub-52	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1175	Sub-53	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1176	Sub-54	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1177	Sub-56	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1178	Sub-57	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1179	Sub-58	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1180	Sub-59	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1181	Sub-82	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1182	Sub-83	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1183	Sub-61	4-ClPh	-CO-	-CH2-	-CH2-cPr-
3-1184	Sub-55	4-ClPh	-CO-	-CH2-	-CH2-cPr-
						3-1185	Sub-33	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1186	Sub-34	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1187	Sub-35	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1188	Sub-36	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1189	Sub-37	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1190	Sub-38	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1191	Sub-39	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1192	Sub-40	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1193	Sub-41	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1194	Sub-42	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1195	Sub-84	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1196	Sub-43	4-ClPh	-CO-	-CH2-	-CH2-cBu-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1197	Sub-44	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1198	Sub-45	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1199	Sub-46	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1200	Sub-47	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1201	Sub-81	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1202	Sub-48	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1203	Sub-49	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1204	Sub-50	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1205	Sub-51	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1206	Sub-52	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1207	Sub-53	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1208	Sub-54	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1209	Sub-56	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1210	Sub-57	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1211	Sub-58	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1212	Sub-59	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1213	Sub-82	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1214	Sub-83	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1215	Sub-61	4-ClPh	-CO-	-CH2-	-CH2-cBu-
3-1216	Sub-55	4-ClPh	-CO-	-CH2-	-CH2-cBu-
						3-1217	Sub-33	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1218	Sub-34	4-ClPh	-CO-	-CH2-	-CH2-cPn-
						3-1219	Sub-35	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1220	Sub-36	4-ClPh	-CO-	-CH2-	-CH2-cPn-
						3-1221	Sub-37	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1222	Sub-38	4-ClPh	-CO-	-CH2-	-CH2-cPn-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1223	Sub-39	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1224	Sub-40	4-ClPh	-CO-	-CH2-	-CH2-cPn-
						3-1225	Sub-41	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1226	Sub-42	4-ClPh	-CO-	-CH2-	-CH2-cPn-
						3-1227	Sub-84	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1228	Sub-43	4-ClPh	-CO-	-CH2-	-CH2-cPn-
						3-1229	Sub-44	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1230	Sub-45	4-ClPh	-CO-	-CH2-	-CH2-cPn-
						3-1231	Sub-46	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1232	Sub-47	4-ClPh	-CO-	-CH2-	-CH2-cPn-
						3-1233	Sub-81	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1234	Sub-48	4-ClPh	-CO-	-CH2-	-CH2-cPn-
						3-1235	Sub-49	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1236	Sub-50	4-ClPh	-CO-	-CH2-	-CH2-cPn-
						3-1237	Sub-51	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1238	Sub-52	4-ClPh	-CO-	-CH2-	-CH2-cPn-
						3-1239	Sub-53	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1240	Sub-54	4-ClPh	-CO-	-CH2-	-CH2-cPn-
						3-1241	Sub-56	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1242	Sub-57	4-ClPh	-CO-	-CH2-	-CH2-cPn-
						3-1243	Sub-58	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1244	Sub-59	4-ClPh	-CO-	-CH2-	-CH2-cPn-
						3-1245	Sub-82	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1246	Sub-83	4-ClPh	-CO-	-CH2-	-CH2-cPn-
						3-1247	Sub-61	4-ClPh	-CO-	-CH2-	-CH2-cPn-
3-1248	Sub-55	4-ClPh	-CO-	-CH2-	-CH2-cPn-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1249	Sub-33	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1250	Sub-34	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1251	Sub-35	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1252	Sub-36	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1253	Sub-37	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1254	Sub-38	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1255	Sub-39	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1256	Sub-40	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1257	Sub-41	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1258	Sub-42	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1259	Sub-84	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1260	Sub-43	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1261	Sub-44	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1262	Sub-45	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1263	Sub-46	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1264	Sub-47	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1265	Sub-81	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1266	Sub-48	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1267	Sub-49	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1268	Sub-50	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1269	Sub-51	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1270	Sub-52	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1271	Sub-53	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1272	Sub-54	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1273	Sub-56	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1274	Sub-57	4-ClPh	-CO-	-CH2-	-CH2-cHx-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1275	Sub-58	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1276	Sub-59	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1277	Sub-82	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1278	Sub-83	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1279	Sub-61	4-ClPh	-CO-	-CH2-	-CH2-cHx-
3-1280	Sub-55	4-ClPh	-CO-	-CH2-	-CH2-cHx-
						3-1281	Sub-33	4-FPh	-CO-	-CH2-	-CH2-
3-1282	Sub-34	4-FPh	-CO-	-CH2-	-CH2-
						3-1283	Sub-35	4-FPh	-CO-	-CH2-	-CH2-
3-1284	Sub-36	4-FPh	-CO-	-CH2-	-CH2-
						3-1285	Sub-37	4-FPh	-CO-	-CH2-	-CH2-
3-1286	Sub-38	4-FPh	-CO-	-CH2-	-CH2-
						3-1287	Sub-39	4-FPh	-CO-	-CH2-	-CH2-
3-1288	Sub-40	4-FPh	-CO-	-CH2-	-CH2-
						3-1289	Sub-41	4-FPh	-CO-	-CH2-	-CH2-
3-1290	Sub-42	4-FPh	-CO-	-CH2-	-CH2-
						3-1291	Sub-84	4-FPh	-CO-	-CH2-	-CH2-
3-1292	Sub-43	4-FPh	-CO-	-CH2-	-CH2-
						3-1293	Sub-44	4-FPh	-CO-	-CH2-	-CH2-
3-1294	Sub-45	4-FPh	-CO-	-CH2-	-CH2-
						3-1295	Sub-46	4-FPh	-CO-	-CH2-	-CH2-
3-1296	Sub-47	4-FPh	-CO-	-CH2-	-CH2-
						3-1297	Sub-81	4-FPh	-CO-	-CH2-	-CH2-
3-1298	Sub-48	4-FPh	-CO-	-CH2-	-CH2-
						3-1299	Sub-49	4-FPh	-CO-	-CH2-	-CH2-
3-1300	Sub-50	4-FPh	-CO-	-CH2-	-CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1301	Sub-51	4-FPh	-CO-	-CH2-	-CH2-
3-1302	Sub-52	4-FPh	-CO-	-CH2-	-CH2-
						3-1303	Sub-53	4-FPh	-CO-	-CH2-	-CH2-
3-1304	Sub-54	4-FPh	-CO-	-CH2-	-CH2-
						3-1305	Sub-56	4-FPh	-CO-	-CH2-	-CH2-
3-1306	Sub-57	4-FPh	-CO-	-CH2-	-CH2-
						3-1307	Sub-58	4-FPh	-CO-	-CH2-	-CH2-
3-1308	Sub-59	4-FPh	-CO-	-CH2-	-CH2-
						3-1309	Sub-82	4-FPh	-CO-	-CH2-	-CH2-
3-1310	Sub-83	4-FPh	-CO-	-CH2-	-CH2-
						3-1311	Sub-61	4-FPh	-CO-	-CH2-	-CH2-
3-1312	Sub-55	4-FPh	-CO-	-CH2-	-CH2-
						3-1313	Sub-33	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1314	Sub-34	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1315	Sub-35	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1316	Sub-36	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1317	Sub-37	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1318	Sub-38	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1319	Sub-39	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1320	Sub-40	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1321	Sub-41	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1322	Sub-42	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1323	Sub-84	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1324	Sub-43	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1325	Sub-44	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1326	Sub-45	4-FPh	-CO-	-CH2-	-CH2CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1327	Sub-46	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1328	Sub-47	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1329	Sub-81	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1330	Sub-48	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1331	Sub-49	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1332	Sub-5O	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1333	Sub-51	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1334	Sub-52	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1335	Sub-53	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1336	Sub-54	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1337	Sub-56	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1338	Sub-57	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1339	Sub-58	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1340	Sub-59	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1341	Sub-82	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1342	Sub-83	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1343	Sub-61	4-FPh	-CO-	-CH2-	-CH2CH2-
3-1344	Sub-55	4-FPh	-CO-	-CH2-	-CH2CH2-
						3-1345	Sub-33	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1346	Sub-34	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1347	Sub-35	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1348	Sub-36	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1349	Sub-37	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1350	Sub-38	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1351	Sub-39	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1352	Sub-40	4-FPh	-CO-	-CH2-	-(CH2)3-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1353	Sub-41	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1354	Sub-42	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1355	Sub-84	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1356	Sub-43	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1357	Sub-44	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1358	Sub-45	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1359	Sub-46	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1360	Sub-47	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1361	Sub-81	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1362	Sub-48	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1363	Sub-49	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1364	Sub-50	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1365	Sub-51	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1366	Sub-52	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1367	Sub-53	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1368	Sub-54	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1369	Sub-56	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1370	Sub-57	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1371	Sub-58	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1372	Sub-59	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1373	Sub-82	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1374	Sub-83	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1375	Sub-61	4-FPh	-CO-	-CH2-	-(CH2)3-
3-1376	Sub-55	4-FPh	-CO-	-CH2-	-(CH2)3-
						3-1377	Sub-33	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1378	Sub-34	4-FPh	-CO-	-CH2-	-CH2C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1379	Sub-35	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1380	Sub-36	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1381	Sub-37	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1382	Sub-38	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1383	Sub-39	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1384	Sub-40	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1385	Sub-41	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1386	Sub-42	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1387	Sub-84	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1388	Sub-43	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1389	Sub-44	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1390	Sub-45	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1391	Sub-46	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1392	Sub-47	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1393	Sub-81	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1394	Sub-48	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1395	Sub-49	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1396	Sub-50	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1397	Sub-51	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1398	Sub-52	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1399	Sub-53	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1400	Sub-54	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1401	Sub-56	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1402	Sub-57	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1403	Sub-58	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1404	Sub-59	4-FPh	-CO-	-CH2-	-CH2C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1405	Sub-82	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1406	Sub-83	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1407	Sub-6l	4-FPh	-CO-	-CH2-	-CH2C(Me)2-
3-1408	Sub-55	4-rPh	-CO-	-CH2-	-CH2C(Me)2-
						3-1409	Sub-33	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1410	Sub-34	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1411	Sub-35	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1412	Sub-36	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1413	Sub-37	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1414	Sub-38	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1415	Sub-39	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1416	Sub-40	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1417	Sub-41	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1418	Sub-42	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1419	Sub-84	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1420	Sub-43	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1421	Sub-44	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1422	Sub-45	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1423	Sub-46	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1424	Sub-47	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1425	Sub-81	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1426	Sub-48	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1427	Sub-49	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1428	Sub-50	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1429	Sub-51	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1430	Sub-52	4-FPh	-CO-	-CH2-	-CH2-cPr-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1431	Sub-53	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1432	Sub-54	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1433	Sub-56	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1434	Sub-57	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1435	Sub-58	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1436	Sub-59	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1437	Sub-82	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1438	Sub-83	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1439	Sub-61	4-FPh	-CO-	-CH2-	-CH2-cPr-
3-1440	Sub-55	4-FPh	-CO-	-CH2-	-CH2-cPr-
						3-1441	Sub-33	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1442	Sub-34	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1443	Sub-35	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1444	Sub-36	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1445	Sub-37	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1446	Sub-38	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1447	Sub-39	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1448	Sub-40	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1449	Sub-41	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1450	Sub-42	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1451	Sub-84	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1452	Sub-43	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1453	Sub-44	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1454	Sub-45	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1455	Sub-46	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1456	Sub-47	4-FPh	-CO-	-CH2-	-CH2-cBu-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1457	Sub-81	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1458	Sub-48	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1459	Sub-49	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1460	Sub-50	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1461	Sub-51	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1462	Sub-52	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1463	Sub-53	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1464	Sub-54	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1465	Sub-56	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1466	Sub-57	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1467	Sub-58	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1468	Sub-59	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1469	Sub-82	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1470	Sub-83	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1471	Sub-61	4-FPh	-CO-	-CH2-	-CH2-cBu-
3-1472	Sub-55	4-FPh	-CO-	-CH2-	-CH2-cBu-
						3-1473	Sub-33	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1474	Sub-34	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1475	Sub-35	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1476	Sub-36	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1477	Sub-37	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1478	Sub-38	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1479	Sub-39	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1480	Sub-40	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1481	Sub-41	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1482	Sub-42	4-FPh	-CO-	-CH2-	-CH2-cPn-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1483	Sub-84	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1484	Sub-43	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1485	Sub-44	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1486	Sub-45	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1487	Sub-46	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1488	Sub-47	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1489	Sub-81	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1490	Sub-48	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1491	Sub-49	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1492	Sub-50	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1493	Sub-51	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1494	Sub-52	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1495	Sub-53	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1496	Sub-54	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1497	Sub-56	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1498	Sub-57	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1499	Sub-58	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1500	Sub-59	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1501	Sub-82	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1502	Sub-83	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1503	Sub-61	4-FPh	-CO-	-CH2-	-CH2-cPn-
3-1504	Sub-55	4-FPh	-CO-	-CH2-	-CH2-cPn-
						3-1505	Sub-33	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1506	Sub-34	4-FPh	-CO-	-CH2-	-CH2-cHx-
						3-1507	Sub-35	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1508	Sub-36	4-FPh	-CO-	-CH2-	-CH2-cHx-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1509	Sub-37	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1510	Sub-38	4-FPh	-CO-	-CH2-	-CH2-cHx-
						3-1511	Sub-39	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1512	Sub-40	4-FPh	-CO-	-CH2-	-CH2-cHx-
						3-1513	Sub-41	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1514	Sub-42	4-FPh	-CO-	-CH2-	-CH2-cHx-
						3-1515	Sub-84	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1516	Sub-43	4-FPh	-CO-	-CH2-	-CH2-cHx-
						3-1517	Sub-44	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1518	Sub-45	4-FPh	-CO-	-CH2-	-CH2-cHx-
						3-1519	Sub-46	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1520	Sub-47	4-FPh	-CO-	-CH2-	-CH2-cHx-
						3-1521	Sub-81	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1522	Sub-48	4-FPh	-CO-	-CH2-	-CH2-cHx-
						3-1523	Sub-49	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1524	Sub-50	4-FPh	-CO-	-CH2-	-CH2-cHx-
						3-1525	Sub-51	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1526	Sub-52	4-FPh	-CO-	-CH2-	-CH2-cHx-
						3-1527	Sub-53	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1528	Sub-54	4-FPh	-CO-	-CH2-	-CH2-cHx-
						3-1529	Sub-56	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1530	Sub-57	4-FPh	-CO-	-CH2-	-CH2-cHx-
						3-1531	Sub-58	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1532	Sub-59	4-FPh	-CO-	-CH2-	-CH2-cHx-
						3-1533	Sub-82	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1534	Sub-83	4-FPh	-CO-	-CH2-	-CH2-cHx-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1535	Sub-61	4-FPh	-CO-	-CH2-	-CH2-cHx-
3-1536	Sub-55	4-FPh	-CO-	-CH2-	-CH2-cHx-
						3-1537	Sub-33	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1538	Sub-34	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1539	Sub-35	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1540	Sub-36	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1541	Sub-37	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1542	Sub-38	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1543	Sub-39	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1544	Sub-40	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1545	Sub-41	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1546	Sub-42	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1547	Sub-84	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1548	Sub-43	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1549	Sub-44	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1550	Sub-45	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1551	Sub-46	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1552	Sub-47	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1553	Sub-81	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1554	Sub-48	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1555	Sub-49	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1556	Sub-50	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1557	Sub-51	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1558	Sub-52	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1559	Sub-53	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1560	Sub-54	3，4-diClPh	-CO-	Single bond	-C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1561	Sub-56	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1562	Sub-57	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1563	Sub-58	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1564	Sub-59	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1565	Sub-82	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1566	Sub-83	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1567	Sub-61	3，4-diClPh	-CO-	Single bond	-C(Me)2-
3-1568	Sub-55	3，4-diClPh	-CO-	Single bond	-C(Me)2-
						3-1569	Sub-33	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1570	Sub-34	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1571	Sub-35	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1572	Sub-36	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1573	Sub-37	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1574	Sub-38	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1575	Sub-39	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1576	Sub-40	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1577	Sub-41	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1578	Sub-42	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1579	Sub-84	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1580	Sub-43	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1581	Sub-44	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1582	Sub-45	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1583	Sub-46	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1584	Sub-47	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1585	Sub-81	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1586	Sub-48	3，4-diClPh	-CO-	-CH2-	-C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1587	Sub-49	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1588	Sub-50	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1589	Sub-51	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1590	Sub-52	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1591	Sub-53	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1592	Sub-54	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1593	Sub-56	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1594	Sub-57	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1595	Sub-58	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1596	Sub-59	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1597	Sub-82	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1598	Sub-83	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1599	Sub-61	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
3-1600	Sub-55	3，4-diClPh	-CO-	-CH2-	-C(Me)2-
						3-1601	Sub-33	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1602	Sub-34	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1603	Sub-35	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1604	Sub-36	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1605	Sub-37	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1606	Sub-38	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1607	Sub-39	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1608	Sub-40	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1609	Sub-41	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1610	Sub-42	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1611	Sub-84	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1612	Sub-43	4-ClPh	-CO-	Single bond	-C(Me)2-

Table 3(cont.)

Chemical combination A serial number.	R1	R2	A	B	E
						3-1613	Sub-44	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1614	Sub-45	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1615	Sub-46	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1616	Sub-47	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1617	Sub-81	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1618	Sub-48	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1619	Sub-49	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1620	Sub-5O	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1621	Sub-51	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1622	Sub-52	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1623	Sub-53	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1624	Sub-54	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1625	Sub-56	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1626	Sub-57	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1627	Sub-58	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1628	Sub-59	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1629	Sub-82	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1630	Sub-83	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1631	Sub-61	4-ClPh	-CO-	Single bond	-C(Me)2-
3-1632	Sub-55	4-ClPh	-CO-	Single bond	-C(Me)2-
						3-1633	Sub-33	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1634	Sub-34	4-ClPh	-CO-	-CH2-	-C(Me)2-
						3-1635	Sub-35	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1636	Sub-36	4-ClPh	-CO-	-CH2-	-C(Me)2-
						3-1637	Sub-37	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1638	Sub-38	4-ClPh	-CO-	-CH2-	-C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1639	Sub-39	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1640	Sub-40	4-ClPh	-CO-	-CH2-	-C(Me)2-
						3-1641	Sub-41	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1642	Sub-42	4-ClPh	-CO-	-CH2-	-C(Me)2-
						3-1643	Sub-84	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1644	Sub-43	4-ClPh	-CO-	-CH2-	-C(Me)2-
						3-1645	Sub-44	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1646	Sub-45	4-ClPh	-CO-	-CH2-	-C(Me)2-
						3-1647	Sub-46	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1648	Sub-47	4-ClPh	-CO-	-CH2-	-C(Me)2-
						3-1649	Sub-81	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1650	Sub-48	4-ClPh	-CO-	-CH2-	-C(Me)2-
						3-1651	Sub-49	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1652	Sub-50	4-ClPh	-CO-	-CH2-	-C(Me)2-
						3-1653	Sub-51	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1654	Sub-52	4-ClPh	-CO-	-CH2-	-C(Me)2-
						3-1655	Sub-53	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1656	Sub-54	4-ClPh	-CO-	-CH2-	-C(Me)2-
						3-1657	Sub-56	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1658	Sub-57	4-ClPh	-CO-	-CH2-	-C(Me)2-
						3-1659	Sub-58	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1660	Sub-59	4-ClPh	-CO-	-CH2-	-C(Me)2-
						3-1661	Sub-82	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1662	Sub-83	4-ClPh	-CO-	-CH2-	-C(Me)2-
						3-1663	Sub-61	4-ClPh	-CO-	-CH2-	-C(Me)2-
3-1664	Sub-55	4-ClPh	-CO-	-CH2-	-C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1665	Sub-33	4-FPh	-CO-	Single bond	-C(Me)2-
3-1666	Sub-34	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1667	Sub-35	4-FPh	-CO-	Single bond	-C(Me)2-
3-1668	Sub-36	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1669	Sub-37	4-FPh	-CO-	Single bond	-C(Me)2-
3-1670	Sub-38	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1671	Sub-39	4-FPh	-CO-	Single bond	-C(Me)2-
3-1672	Sub-40	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1673	Sub-41	4-FPh	-CO-	Single bond	-C(Me)2-
3-1674	Sub-42	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1675	Sub-84	4-FPh	-CO-	Single bond	-C(Me)2-
3-1676	Sub-43	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1677	Sub-44	4-FPh	-CO-	Single bond	-C(Me)2-
3-1678	Sub-45	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1679	Sub-46	4-FPh	-CO-	Single bond	-C(Me)2-
3-1680	Sub-47	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1681	Sub-81	4-FPh	-CO-	Single bond	-C(Me)2-
3-1682	Sub-48	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1683	Sub-49	4-FPh	-CO-	Single bond	-C(Me)2-
3-1684	Sub-50	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1685	Sub-51	4-FPh	-CO-	Single bond	-C(Me)2-
3-1686	Sub-52	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1687	Sub-53	4-FPh	-CO-	Single bond	-C(Me)2-
3-1688	Sub-54	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1689	Sub-56	4-FPh	-CO-	Single bond	-C(Me)2-
3-1690	Sub-57	4-FPh	-CO-	Single bond	-C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1691	Sub-58	4-FPh	-CO-	Single bond	-C(Me)2-
3-1692	Sub-59	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1693	Sub-82	4-FPh	-CO-	Single bond	-C(Me)2-
3-1694	Sub-83	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1695	Sub-61	4-FPh	-CO-	Single bond	-C(Me)2-
3-1696	Sub-55	4-FPh	-CO-	Single bond	-C(Me)2-
						3-1697	Sub-33	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1698	Sub-34	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1699	Sub-35	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1700	Sub-36	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1701	Sub-37	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1702	Sub-38	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1703	Sub-39	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1704	Sub-40	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1705	Sub-41	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1706	Sub-42	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1707	Sub-84	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1708	Sub-43	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1709	Sub-44	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1710	Sub-45	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1711	Sub-46	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1712	Sub-47	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1713	Sub-81	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1714	Sub-48	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1715	Sub-49	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1716	Sub-50	4-FPh	-CO-	-CH2-	-C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1717	Sub-51	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1718	Sub-52	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1719	Sub-53	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1720	Sub-54	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1721	Sub-56	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1722	Sub-57	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1723	Sub-58	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1724	Sub-59	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1725	Sub-82	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1726	Sub-83	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1727	Sub-61	4-FPh	-CO-	-CH2-	-C(Me)2-
3-1728	Sub-55	4-FPh	-CO-	-CH2-	-C(Me)2-
						3-1729	Sub-37	3，4-diClPh	-CH2-	Single bond	-CH2-
3-1730	Sub-38	3，4-diClPh	-CH2-	Single bond	-CH2-
						3-1731	Sub-39	3，4-diClPh	-CH2-	Single bond	-CH2-
3-1732	Sub-40	3，4-diClPh	-CH2-	Single bond	-CH2-
						3-1733	Sub-41	3，4-diClPh	-CH2-	Single bond	-CH2-
3-1734	Sub-42	3，4-diClPh	-CH2-	Single bond	-CH2-
						3-1735	Sub-84	3，4-diClPh	-CH2-	Single bond	-CH2-
3-1736	Sub-81	3，4-diClPh	-CH2-	Single bond	-CH2-
						3-1737	Sub-48	3，4-diClPh	-CH2-	Single bond	-CH2-
3-1738	Sub-37	4-ClPh	-CH2-	Single bond	-CH2-
						3-1739	Sub-38	4-ClPh	-CH2-	Single bond	-CH2-
3-1740	Sub-39	4-ClPh	-CH2-	Single bond	-CH2-
						3-1741	Sub-40	4-ClPh	-CH2-	Single bond	-CH2-
3-1742	Sub-41	4-ClPh	-CH2-	Single bond	-CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1743	Sub-42	4-ClPh	-CH2-	Single bond	-CH2-
3-1744	Sub-84	4-ClPh	-CH2-	Single bond	-CH2-
						3-1745	Sub-81	4-ClPh	-CH2-	Single bond	-CH2-
3-1746	Sub-48	4-ClPh	-CH2-	Single bond	-CH2-
						3-1747	Sub-37	4-FPh	-CH2-	Single bond	-CH2-
3-1748	Sub-38	4-FPh	-CH2-	Single bond	-CH2-
						3-1749	Sub-39	4-FPh	-CH2-	Single bond	-CH2-
3-1750	Sub-40	4-FPh	-CH2-	Single bond	-CH2-
						3-1751	Sub-41	4-FPh	-CH2-	Single bond	-CH2-
3-1752	Sub-42	4-FPh	-CH2-	Single bond	-CH2-
						3-1753	Sub-84	4-FPh	-CH2-	Single bond	-CH2-
3-1754	Sub-81	4-FPh	-CH2-	Single bond	-CH2-
						3-1755	Sub-48	4-FPh	-CH2-	Single bond	-CH2-
3-1756	Sub-37	3，4-diClPh	-CH2-	Single bond	-CH2CH2-
						3-1757	Sub-38	3，4-diClPh	-CH2-	Single bond	-CH2CH2-
3-1758	Sub-39	3，4-diClPh	-CH2-	Single bond	-CH2CH2-
						3-1759	Sub-40	3，4-diClPh	-CH2-	Single bond	-CH2CH2-
3-1760	Sub-41	3，4-diClPh	-CH2-	Single bond	-CH2CH2-
						3-1761	Sub-42	3，4-diClPh	-CH2-	Single bond	-CH2CH2-
3-1762	Sub-84	3，4-diClPh	-CH2-	Single bond	-CH2CH2-
						3-1763	Sub-81	3，4-diClPh	-CH2-	Single bond	-CH2CH2-
3-1764	Sub-48	3，4-diClPh	-CH2-	Single bond	-CH2CH2-
						3-1765	Sub-37	4-ClPh	-CH2-	Single bond	-CH2CH2-
3-1766	Sub-38	4-ClPh	-CH2-	Single bond	-CH2CH2-
						3-1767	Sub-39	4-ClPh	-CH2-	Single bond	-CH2CH2-
3-1768	Sub-40	4-ClPh	-CH2-	Single bond	-CH2CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1769	Sub-41	4-ClPh	-CH2-	Single bond	-CH2CH2-
3-1770	Sub-42	4-ClPh	-CH2-	Single bond	-CH2CH2-
						3-1771	Sub-84	4-ClPh	-CH2-	Single bond	-CH2CH2-
3-1772	Sub-81	4-ClPh	-CH2-	Single bond	-CH2CH2-
						3-1773	Sub-48	4-ClPh	-CH2-	Single bond	-CH2CH2-
3-1774	Sub-37	4-FPh	-CH2-	Single bond	-CH2CH2-
						3-1775	Sub-38	4-FPh	-CH2-	Single bond	-CH2CH2-
3-1776	Sub-39	4-FPh	-CH2-	Single bond	-CH2CH2-
						3-1777	Sub-40	4-FPh	-CH2-	Single bond	-CH2CH2-
3-1778	Sub-41	4-FPh	-CH2-	Single bond	-CH2CH2-
						3-1779	Sub-42	4-FPh	-CH2-	Single bond	-CH2CH2-
3-1780	Sub-84	4-FPh	-CH2-	Single bond	-CH2CH2-
						3-1781	Sub-81	4-FPh	-CH2-	Single bond	-CH2CH2-
3-1782	Sub-48	4-FPh	-CH2-	Single bond	-CH2CH2-
						3-1783	Sub-37	3，4-diClPh	-CH2-	Single bond	-(CH2)3-
3-1784	Sub-38	3，4-diClPh	-CH2-	Single bond	-(CH2)3-
						3-1785	Sub-39	3，4-diClPh	-CH2-	Single bond	-(CH2)3-
3-1786	Sub-40	3，4-diClPh	-CH2-	Single bond	-(CH2)3-
						3-1787	Sub-41	3，4-diClPh	-CH2-	Single bond	-(CH2)3-
3-1788	Sub-42	3，4-diClPh	-CH2-	Single bond	-(CH2)3-
						3-1789	Sub-84	3，4-diClPh	-CH2-	Single bond	-(CH2)3-
3-1790	Sub-81	3，4-diClPh	-CH2-	Single bond	-(CH2)3-
						3-1791	Sub-48	3，4-diClPh	-CH2-	Single bond	-(CH2)3-
3-1792	Sub-37	4-ClPh	-CH2-	Single bond	-(CH2)3-
						3-1793	Sub-38	4-ClPh	-CH2-	Single bond	-(CH2)3-
3-1794	Sub-39	4-ClPh	-CH2-	Single bond	-(CH2)3-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1795	Sub-40	4-ClPh	-CH2-	Single bond	-(CH2)x-
3-1796	Sub-41	4-ClPh	-CH2-	Single bond	-(CH2)3-
						3-1797	Sub-42	4-ClPh	-CH2-	Single bond	-(CH2)3-
3-1798	Sub-84	4-ClPh	-CH2-	Single bond	-(CH2)3-
						3-1799	Sub-81	4-ClPh	-CH2-	Single bond	-(CH2)3-
3-1800	Sub-48	4-ClPh	-CH2-	Single bond	-(CH2)3-
						3-1801	Sub-37	4-FPh	-CH2-	Single bond	-(CH2)3-
3-1802	Sub-38	4-FPh	-CH2-	Single bond	-(CH2)3-
						3-1803	Sub-39	4-FPh	-CH2-	Single bond	-(CH2)3-
3-1804	Sub-40	4-FPh	-CH2-	Single bond	-(CH2)3-
						3-1805	Sub-41	4-FPh	-CH2-	Single bond	-(CH2)3-
3-1806	Sub-42	4-FPh	-CH2-	Single bond	-(CH2)3-
						3-1807	Sub-84	4-FPh	-CH2-	Single bond	-(CH2)3-
3-1808	Sub-81	4-FPh	-CH2-	Single bond	-(CH2)3-
						3-1809	Sub-48	4-FPh	-CH2-	Single bond	-(CH2)3-
3-1810	Sub-37	3，4-diClPh	-CH2-	Single bond	-CH2C(Me)2-
						3-1811	Sub-38	3，4-diClPh	-CH2-	Single bond	-CH2C(Me)2-
3-1812	Sub-39	3，4-diClPh	-CH2-	Single bond	-CH2C(Me)2-
						3-1813	Sub-40	3，4-diClPh	-CH2-	Single bond	-CH2C(Me)2-
3-1814	Sub-41	3，4-diClPh	-CH2-	Single bond	-CH2C(Me)2-
						3-1815	Sub-42	3，4-diClPh	-CH2-	Single bond	-CH2C(Me)2-
3-1816	Sub-84	3，4-diClPh	-CH2-	Single bond	-CH2C(Me)2-
						3-1817	Sub-81	3，4-diClPh	-CH2-	Single bond	-CH2C(Me)2-
3-1818	Sub-48	3，4-diClPh	-CH2-	Single bond	-CH2C(Me)2-
						3-1819	Sub-37	4-ClPh	-CH2-	Single bond	-CH2C(Me)2-
3-1820	Sub-38	4-ClPh	-CH2-	Single bond	-CH2C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1821	Sub-39	4-ClPh	-CH2-	Single bond	-CH2C(Me)2-
3-1822	Sub-40	4-ClPh	-CH2-	Single bond	-CH2C(Me)2-
						3-1823	Sub-41	4-ClPh	-CH2-	Single bond	-CH2C(Me)2-
3-1824	Sub-42	4-ClPh	-CH2-	Single bond	-CH2C(Me)2-
						3-1825	Sub-84	4-ClPh	-CH2-	Single bond	-CH2C(Me)2-
3-1826	Sub-81	4-ClPh	-CH2-	Single bond	-CH2C(Me)2-
						3-1827	Sub-48	4-ClPh	-CH2-	Single bond	-CH2C(Me)2-
3-1828	Sub-37	4-FPh	-CH2-	Single bond	-CH2C(Me)2-
						3-1829	Sub-38	4-FPh	-CH2-	Single bond	-CH2C(Me)2-
3-1830	Sub-39	4-FPh	-CH2-	Single bond	-CH2C(Me)2-
						3-1831	Sub-40	4-FPh	-CH2-	Single bond	-CH2C(Me)2-
3-1832	Sub-41	4-FPh	-CH2-	Single bond	-CH2C(Me)2-
						3-1833	Sub-42	4-FPh	-CH2-	Single bond	-CH2C(Me)2-
3-1834	Sub-84	4-FPh	-CH2-	Single bond	-CH2C(Me)2-
						3-1835	Sub-81	4-FPh	-CH2-	Single bond	-CH2C(Me)2-
3-1836	Sub-48	4-FPh	-CH2-	Single bond	-CH2C(Me)2-
						3-1837	Sub-37	3，4-diClPh	-CH2-	Single bond	-CH2-cPr-
3-1838	Sub-38	3，4-diClPh	-CH2-	Single bond	-CH2-cPr-
						3-1839	Sub-39	3，4-diClPh	-CH2-	Single bond	-CH2-cPr-
3-1840	Sub-40	3，4-diClPh	-CH2-	Single bond	-CH2-cPr-
						3-1841	Sub-41	3，4-diClPh	-CH2-	Single bond	-CH2-cPr-
3-1842	Sub-42	3，4-diClPh	-CH2-	Single bond	-CH2-cPr-
						3-1843	Sub-84	3，4-diClPh	-CH2-	Single bond	-CH2-cPr-
3-1844	Sub-81	3，4-diClPh	-CH2-	Single bond	-CH2-cPr-
						3-1845	Sub-48	3，4-diClPh	-CH2-	Single bond	-CH2-cPr-
3-1846	Sub-37	4-ClPh	-CH2-	Single bond	-CH2-cPr-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1847	Sub-38	4-ClPh	-CH2-	Single bond	-CH2-cPr-
3-1848	Sub-39	4-ClPh	-CH2-	Single bond	-CH2-cPr-
						3-1849	Sub-40	4-ClPh	-CH2-	Single bond	-CH2-cPr-
3-1850	Sub-41	4-ClPh	-CH2-	Single bond	-CH2-cPr-
						3-1851	Sub-42	4-ClPh	-CH2-	Single bond	-CH2-cPr-
3-1852	Sub-84	4-ClPh	-CH2-	Single bond	-CH2-cPr-
						3-1853	Sub-81	4-ClPh	-CH2-	Single bond	-CH2-cPr-
3-1854	Sub-48	4-ClPh	-CH2-	Single bond	-CH2-cPr-
						3-1855	Sub-37	4-FPh	-CH2-	Single bond	-CH2-cPr-
3-1856	Sub-38	4-FPh	-CH2-	Single bond	-CH2-cPr-
						3-1857	Sub-39	4-FPh	-CH2-	Single bond	-CH2-cPr-
3-1858	Sub-40	4-FPh	-CH2-	Single bond	-CH2-cPr-
						3-1859	Sub-41	4-FPh	-CH2-	Single bond	-CH2-cPr-
3-1860	Sub-42	4-FPh	-CH2-	Single bond	-CH2-cPr-
						3-1861	Sub-84	4-FPh	-CH2-	Single bond	-CH2-cPr-
3-1862	Sub-81	4-FPh	-CH2-	Single bond	-CH2-cPr-
						3-1863	Sub-48	4-FPh	-CH2-	Single bond	-CH2-cPr-
3-1864	Sub-37	3，4-diClPh	-CH2-	Single bond	-C(Me)2-
						3-1865	Sub-38	3，4-diClPh	-CH2-	Single bond	-C(Me)2-
3-1866	Sub-39	3，4-diClPh	-CH2-	Single bond	-C(Me)2-
						3-1867	Sub-40	3，4-diClPh	-CH2-	Single bond	-C(Me)2-
3-1868	Sub-41	3，4-diClPh	-CH2-	Single bond	-C(Me)2-
						3-1869	Sub-42	3，4-diClPh	-CH2-	Single bond	-C(Me)2-
3-1870	Sub-84	3，4-diClPh	-CH2-	Single bond	-C(Me)2-
						3-1871	Sub-81	3，4-diClPh	-CH2-	Single bond	-C(Me)2-
3-1872	Sub-48	3，4-diClPh	-CH2-	Single bond	-C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1873	Sub-37	4-ClPh	-CH2-	Single bond	-C(Me)2-
3-1874	Sub-38	4-ClPh	-CH2-	Single bond	-C(Me)2-
						3-1875	Sub-39	4-ClPh	-CH2-	Single bond	-C(Me)2-
3-1876	Sub-40	4-ClPh	-CH2-	Single bond	-C(Me)2-
						3-1877	Sub-41	4-ClPh	-CH2-	Single bond	-C(Me)2-
3-1878	Sub-42	4-ClPh	-CH2-	Single bond	-C(Me)2-
						3-1879	Sub-84	4-ClPh	-CH2-	Single bond	-C(Me)2-
3-1880	Sub-81	4-ClPh	-CH2-	Single bond	-C(Me)2-
						3-1881	Sub-48	4-ClPh	-CH2-	Single bond	-C(Me)2-
3-1882	Sub-37	4-FPh	-CH2-	Single bond	-C(Me)2-
						3-1883	Sub-38	4-FPh	-CH2-	Single bond	-C(Me)2-
3-1884	Sub-39	4-FPh	-CH2-	Single bond	-C(Me)2-
						3-1885	Sub-40	4-FPh	-CH2-	Single bond	-C(Me)2-
3-1886	Sub-41	4-FPh	-CH2-	Single bond	-C(Me)2-
						3-1887	Sub-42	4-FPh	-CH2-	Single bond	-C(Me)2-
3-1888	Sub-84	4-FPh	-CH2-	Single bond	-C(Me)2-
						3-1889	Sub-81	4-FPh	-CH2-	Single bond	-C(Me)2-
3-1890	Sub-48	4-FPh	-CH2-	Single bond	-C(Me)2-
						3-1891	Sub-37	3，4-diClPh	-CH2-	-CH2-	-CH2-
3-1892	Sub-38	3，4-diClPh	-CH2-	-CH2-	-CH2-
						3-1893	Sub-39	3，4-diClPh	-CH2-	-CH2-	-CH2-
3-1894	Sub-40	3，4-diClPh	-CH2-	-CH2-	-CH2-
						3-1895	Sub-41	3，4-diClPh	-CH2-	-CH2-	-CH2-
3-1896	Sub-42	3，4-diClPh	-CH2-	-CH2-	-CH2-
						3-1897	Sub-84	3，4-diClPh	-CH2-	-CH2-	-CH2-
3-1898	Sub-81	3，4-diClPh	-CH2-	-CH2-	-CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1899	Sub-48	3，4-diClPh	-CH2-	-CH2-	-CH2-
3-1900	Sub-37	4-ClPh	-CH2-	-CH2-	-CH2-
						3-1901	Sub-38	4-ClPh	-CH2-	-CH2-	-CH2-
3-1902	Sub-39	4-ClPh	-CH2-	-CH2-	-CH2-
						3-1903	Sub-40	4-ClPh	-CH2-	-CH2-	-CH2-
3-1904	Sub-41	4-ClPh	-CH2-	-CH2-	-CH2-
						3-1905	Sub-42	4-ClPh	-CH2-	-CH2-	-CH2-
3-1906	Sub-84	4-ClPh	-CH2-	-CH2-	-CH2-
						3-1907	Sub-81	4-ClPh	-CH2-	-CH2-	-CH2-
3-1908	Sub-48	4-ClPh	-CH2-	-CH2-	-CH2-
						3-1909	Sub-37	4-FPh	-CH2-	-CH2-	-CH2-
3-1910	Sub-38	4-FPh	-CH2-	-CH2-	-CH2-
						3-1911	Sub-39	4-FPh	-CH2-	-CH2-	-CH2-
3-1912	Sub-40	4-FPh	-CH2-	-CH2-	-CH2-
						3-1913	Sub-41	4-FPh	-CH2-	-CH2-	-CH2-
3-1914	Sub-42	4-FPh	-CH2-	-CH2-	-CH2-
						3-1915	Sub-84	4-FPh	-CH2-	-CH2-	-CH2-
3-1916	Sub-81	4-FPh	-CH2-	-CH2-	-CH2-
						3-1917	Sub-48	4-FPh	-CH2-	-CH2-	-CH2-
3-1918	Sub-37	3，4-diClPh	-CH2-	-CH2-	-CH2CH2-
						3-1919	Sub-38	3，4-diClPh	-CH2-	-CH2-	-CH2CH2-
3-1920	Sub-39	3，4-diClPh	-CH2-	-CH2-	-CH2CH2-
						3-1921	Sub-40	3，4-diClPh	-CH2-	-CH2-	-CH2CH2-
3-1922	Sub-41	3，4-diClPh	-CH2-	-CH2-	-CH2CH2-
						3-1923	Sub-42	3，4-diClPh	-CH2-	-CH2-	-CH2CH2-
3-1924	Sub-84	3，4-diClPh	-CH2-	-CH2-	-CH2CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1925	Sub-81	3，4-diClPh	-CH2-	-CH2-	-CH2CH2-
3-1926	Sub-48	3，4-diClPh	-CH2-	-CH2-	-CH2CH2-
						3-1927	Sub-37	4-ClPh	-CH2-	-CH2-	-CH2CH2-
3-1928	Sub-38	4-ClPh	-CH2-	-CH2-	-CH2CH2-
						3-1929	Sub-39	4-ClPh	-CH2-	-CH2-	-CH2CH2-
3-1930	Sub-40	4-ClPh	-CH2-	-CH2-	-CH2CH2-
						3-1931	Sub-41	4-ClPh	-CH2-	-CH2-	-CH2CH2-
3-1932	Sub-42	4-ClPh	-CH2-	-CH2-	-CH2CH2-
						3-1933	Sub-84	4-ClPh	-CH2-	-CH2-	-CH2CH2-
3-1934	Sub-81	4-ClPh	-CH2-	-CH2-	-CH2CH2-
						3-1935	Sub-48	4-ClPh	-CH2-	-CH2-	-CH2CH2-
3-1936	Sub-37	4-FPh	-CH2-	-CH2-	-CH2CH2-
						3-1937	Sub-38	4-FPh	-CH2-	-CH2-	-CH2CH2-
3-1938	Sub-39	4-FPh	-CH2-	-CH2-	-CH2CH2-
						3-1939	Sub-40	4-FPh	-CH2-	-CH2-	-CH2CH2-
3-1940	Sub-41	4-FPh	-CH2-	-CH2-	-CH2CH2-
						3-1941	Sub-42	4-FPh	-CH2-	-CH2-	-CH2CH2-
3-1942	Sub-84	4-FPh	-CH2-	-CH2-	-CH2CH2-
						3-1943	Sub-81	4-FPh	-CH2-	-CH2-	-CH2CH2-
3-1944	Sub-48	4-FPh	-CH2-	-CH2-	-CH2CH2-
						3-1945	Sub-37	3，4-diClPh	-CH2-	-CH2-	-(CH2)3-
3-1946	Sub-38	3，4-diClPh	-CH2-	-CH2-	-(CH2)3-
						3-1947	Sub-39	3，4-diClPh	-CH2-	-CH2-	-(CH2)3-
3-1948	Sub-40	3，4-diClPh	-CH2-	-CH2-	-(CH2)3-
						3-1949	Sub-41	3，4-diClPh	-CH2-	-CH2-	-(CH2)3-
3-1950	Sub-42	3，4-diClPh	-CH2-	-CH2-	-(CH2)3-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1951	Sub-84	3，4-diClPh	-CH2-	-CH2-	-(CH2)3-
3-1952	Sub-81	3，4-diClPh	-CH2-	-CH2-	-(CH2)3-
						3-1953	Sub-48	3，4-diClPh	-CH2-	-CH2-	-(CH2)3-
3-1954	Sub-37	4-ClPh	-CH2-	-CH2-	-(CH2)3-
						3-1955	Sub-38	4-ClPh	-CH2-	-CH2-	-(CH2)3-
3-1956	Sub-39	4-ClPh	-CH2-	-CH2-	-(CH2)3-
						3-1957	Sub-40	4-ClPh	-CH2-	-CH2-	-(CH2)3-
3-1958	Sub-41	4-ClPh	-CH2-	-CH2-	-(CH2)3-
						3-1959	Sub-42	4-ClPh	-CH2-	-CH2-	-(CH2)3-
3-1960	Sub-84	4-ClPh	-CH2-	-CH2-	-(CH2)3-
						3-1961	Sub-81	4-ClPh	-CH2-	-CH2-	-(CH2)3-
3-1962	Sub-48	4-ClPh	-CH2-	-CH2-	-(CH2)3-
						3-1963	Sub-37	4-FPh	-CH2-	-CH2-	-(CH2)3-
3-1964	Sub-38	4-FPh	-CH2-	-CH2-	-(CH2)3-
						3-1965	Sub-39	4-FPh	-CH2-	-CH2-	-(CH2)3-
3-1966	Sub-40	4-FPh	-CH2-	-CH2-	-(CH2)3-
						3-1967	Sub-41	4-FPh	-CH2-	-CH2-	-(CH2)3-
3-1968	Sub-42	4-FPh	-CH2-	-CH2-	-(CH2)3-
						3-1969	Sub-84	4-FPh	-CH2-	-CH2-	-(CH2)3-
3-1970	Sub-81	4-FPh	-CH2-	-CH2-	-(CH2)3-
						3-1971	Sub-48	4-FPh	-CH2-	-CH2-	-(CH2)3-
3-1972	Sub-37	3，4-diClPh	-CH2-	-CH2-	-CH2C(Me)2-
						3-1973	Sub-38	3，4-diClPh	-CH2-	-CH2-	-CH2C(Me)2-
3-1974	Sub-39	3，4-diClPh	-CH2-	-CH2-	-CH2C(Me)2-
						3-1975	Sub-40	3，4-diClPh	-CH2-	-CH2-	-CH2C(Me)2-
3-1976	Sub-41	3，4-diClPh	-CH2-	-CH2-	-CH2C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-1977	Sub-42	3，4-diClPh	-CH2-	-CH2-	-CH2C(Me)2-
3-1978	Sub-84	3，4-diClPh	-CH2-	-CH2-	-CH2C(Me)2-
						3-1979	Sub-81	3，4-diClPh	-CH2-	-CH2-	-CH2C(Me)2-
3-1980	Sub-48	3，4-diClPh	-CH2-	-CH2-	-CH2C(Me)2-
						3-1981	Sub-37	4-ClPh	-CH2-	-CH2-	-CH2C(Me)2-
3-1982	Sub-38	4-ClPh	-CH2-	-CH2-	-CH2C(Me)2-
						3-1983	Sub-39	4-ClPh	-CH2-	-CH2-	-CH2C(Me)2-
3-1984	Sub-40	4-ClPh	-CH2-	-CH2-	-CH2C(Me)2-
						3-1985	Sub-41	4-ClPh	-CH2-	-CH2-	-CH2C(Me)2-
3-1986	Sub-42	4-ClPh	-CH2-	-CH2-	-CH2C(Me)2-
						3-1987	Sub-84	4-ClPh	-CH2-	-CH2-	-CH2C(Me)2-
3-1988	Sub-81	4-ClPh	-CH2-	-CHx-	-CH2C(Me)2-
						3-1989	Sub-48	4-ClPh	-CH2-	-CH2-	-CH2C(Me)2-
3-1990	Sub-37	4-FPh	-CH2-	-CH2-	-CH2C(Me)2-
						3-1991	Sub-38	4-FPh	-CH2-	-CH2-	-CH2C(Me)2-
3-1992	Sub-39	4-FPh	-CH2-	-CH2-	-CH2C(Me)2-
						3-1993	Sub-40	4-FPh	-CH2-	-CH2-	-CH2C(Me)2-
3-1994	Sub-41	4-FPh	-CH2-	-CH2-	-CH2C(Me)2-
						3-1995	Sub-42	4-FPh	-CH2-	-CH2-	-CH2C(Me)2-
3-1996	Sub-84	4-FPh	-CH2-	-CH2-	-CH2C(Me)2-
						3-1997	Sub-81	4-FPh	-CH2-	-CH2-	-CH2C(Me)2-
3-1998	Sub-48	4-FPh	-CH2-	-CH2-	-CH2C(Me)2-
						3-1999	Sub-37	3，4-diClPh	-CH2-	-CH2-	-CH2-cPr-
3-2000	Sub-38	3，4-diClPh	-CH2-	-CH2-	-CH2-cPr-
						3-2001	Sub-39	3，4-diClPh	-CH2-	-CH2-	-CH2-cPr-
3-2002	Sub-40	3，4-diClPh	-CH2-	-CH2-	-CH2-cPr-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2003	Sub-41	3，4-diClPh	-CH2-	-CH2-	-CH2-cPr-
3-2004	Sub-42	3，4-diClPh	-CH2-	-CH2-	-CH2-cPr-
						3-2005	Sub-84	3，4-diClPh	-CH2-	-CH2-	-CH2-cPr-
3-2006	Sub-81	3，4-diClPh	-CH2-	-CH2-	-CH2-cPr-
						3-2007	Sub-48	3，4-diClPh	-CH2-	-CH2-	-CH2-cPr-
3-2008	Sub-37	4-ClPh	-CH2-	-CH2-	-CH2-cPr-
						3-2009	Sub-38	4-ClPh	-CH2-	-CH2-	-CH2-cPr-
3-2010	Sub-39	4-ClPh	-CH2-	-CH2-	-CH2-cPr-
						3-2011	Sub-40	4-ClPh	-CH2-	-CH2-	-CH2-cPr-
3-2012	Sub-41	4-ClPh	-CH2-	-CH2-	-CH2-cPr-
						3-2013	Sub-42	4-ClPh	-CH2-	-CH2-	-CH2-cPr-
3-2014	Sub-84	4-ClPh	-CH2-	-CH2-	-CH2-cPr-
						3-2015	Sub-81	4-ClPh	-CH2-	-CH2-	-CH2-cPr-
3-2016	Sub-48	4-ClPh	-CH2-	-CH2-	-CH2-cPr-
						3-2017	Sub-37	4-FPh	-CH2-	-CH2-	-CH2-cPr-
3-2018	Sub-38	4-FPh	-CH2-	-CH2-	-CH2-cPr-
						3-2019	Sub-39	4-FPh	-CH2-	-CH2-	-CH2-cPr-
3-2020	Sub-40	4-FPh	-CH2-	-CH2-	-CH2-cPr-
						3-2021	Sub-41	4-FPh	-CH2-	-CH2-	-CH2-cPr-
3-2022	Sub-42	4-FPh	-CH2-	-CH2-	-CH2-cPr-
						3-2023	Sub-84	4-FPh	-CH2-	-CH2-	-CH2-cPr-
3-2024	Sub-81	4-FPh	-CH2-	-CH2-	-CH2-cPr-
						3-2025	Sub-48	4-FPh	-CH2-	-CH2-	-CH2-cPr-
3-2026	Sub-37	3，4-diClPh	-CH2-	-CH2-	-C(Me)2-
						3-2027	Sub-38	3，4-diClPh	-CH2-	-CH2-	-C(Me)2-
3-2028	Sub-39	3，4-diClPh	-CH2-	-CH2-	-C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2029	Sub-40	3，4-diClPh	-CH2-	-CH2-	-C(Me)2-
3-2030	Sub-41	3，4-diClPh	-CH2-	-CH2-	-C(Me)2-
						3-2031	Sub-42	3，4-diClPh	-CH2-	-CH2-	-C(Me)2-
3-2032	Sub-84	3，4-diClPh	-CH2-	-CH2-	-C(Me)2-
						3-2033	Sub-81	3，4-diClPh	-CH2-	-CH2-	-C(Me)2-
3-2034	Sub-48	3，4-diClPh	-CH2-	-CH2-	-C(Me)2-
						3-2035	Sub-37	4-ClPh	-CH2-	-CH2-	-C(Me)2-
3-2036	Sub-38	4-ClPh	-CH2-	-CH2-	-C(Me)2-
						3-2037	Sub-39	4-ClPh	-CH2-	-CH2-	-C(Me)2-
3-2038	Sub-40	4-ClPh	-CH2-	-CH2-	-C(Me)2-
						3-2039	Sub-41	4-ClPh	-CH2-	-CH2-	-C(Me)2-
3-2040	Sub-42	4-ClPh	-CH2-	-CH2-	-C(Me)2-
						3-2041	Sub-84	4-ClPh	-CH2-	-CH2-	-C(Me)2-
3-2042	Sub-81	4-ClPh	-CH2-	-CH2-	-C(Me)2-
						3-2043	Sub-48	4-ClPh	-CH2-	-CH2-	-C(Me)2-
3-2044	Sub-37	4-FPh	-CH2-	-CH2-	-C(Me)2-
						3-2045	Sub-38	4-FPh	-CH2-	-CH2-	-C(Me)2-
3-2046	Sub-39	4-FPh	-CH2-	-CH2-	-C(Me)2-
						3-2047	Sub-40	4-FPh	-CH2-	-CH2-	-C(Me)2-
3-2048	Sub-41	4-FPh	-CH2-	-CH2-	-C(Me)2-
						3-2049	Sub-42	4-FPh	-CH2-	-CH2-	-C(Me)2-
3-2050	Sub-84	4-FPh	-CH2-	-CH2-	-C(Me)2-
						3-2051	Sub-81	4-FPh	-CH2-	-CH2-	-C(Me)2-
3-2052	Sub-48	4-FPh	-CH2-	-CH2-	-C(Me)2-
						3-2053	Sub-37	3，4-diClPh	-SO2-	Single bond	-CH2-
3-2054	Sub-38	3，4-diClPh	-SO2-	Single bond	-CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2055	Sub-39	3，4-diClPh	-SO2-	Single bond	-CH2-
3-2056	Sub-40	3，4-diClPh	-SO2-	Single bond	-CH2-
						3-2057	Sub-41	3，4-diClPh	-SO2-	Single bond	-CH2-
3-2058	Sub-42	3，4-diClPh	-SO2-	Single bond	-CH2-
						3-2059	Sub-84	3，4-diClPh	-SO2-	Single bond	-CH2-
3-2060	Sub-81	3，4-diClPh	-SO2-	Single bond	-CH2-
						3-2061	Sub-48	3，4-diClPh	-SO2-	Single bond	-CH2-
3-2062	Sub-37	4-ClPh	-SO2-	Single bond	-CH2-
						3-2063	Sub-38	4-ClPh	-SO2-	Single bond	-CH2-
3-2064	Sub-39	4-ClPh	-SO2-	Single bond	-CH2-
						3-2065	Sub-40	4-ClPh	-SO2-	Single bond	-CH2-
3-2066	Sub-41	4-ClPh	-SO2-	Single bond	-CH2-
						3-2067	Sub-42	4-ClPh	-SO2-	Single bond	-CH2-
3-2068	Sub-84	4-ClPh	-SO2-	Single bond	-CH2-
						3-2069	Sub-81	4-ClPh	-SO2-	Single bond	-CH2-
3-2070	Sub-48	4-ClPh	-SO2-	Single bond	-CH2-
						3-2071	Sub-37	4-FPh	-SO2-	Single bond	-CH2-
3-2072	Sub-38	4-FPh	-SO2-	Single bond	-CH2-
						3-2073	Sub-39	4-FPh	-SO2-	Single bond	-CH2-
3-2074	Sub-40	4-FPh	-SO2-	Single bond	-CH2-
						3-2075	Sub-41	4-FPh	-SO2-	Single bond	-CH2-
3-2076	Sub-42	4-FPh	-SO2-	Single bond	-CH2-
						3-2077	Sub-84	4-FPh	-SO2-	Single bond	-CH2-
3-2078	Sub-81	4-FPh	-SO2-	Single bond	-CH2-
						3-2079	Sub-48	4-FPh	-SO2-	Single bond	-CH2-
3-2080	Sub-37	3，4-diClPh	-SO2-	Single bond	-CH2CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2081	Sub-38	3，4-diClPh	-SO2-	Single bond	-CH2CH2-
3-2082	Sub-39	3，4-diClPh	-SO2-	Single bond	-CH2CH2-
						3-2083	Sub-40	3，4-diClPh	-SO2-	Single bond	-CH2CH2-
3-2084	Sub-41	3，4-diClPh	-SO2-	Single bond	-CH2CH2-
						3-2085	Sub-42	3，4-diClPh	-SO2-	Single bond	-CH2CH2-
3-2086	Sub-84	3，4-diClPh	-SO2-	Single bond	-CH2CH2-
						3-2087	Sub-81	3，4-diClPh	-SO2-	Single bond	-CH2CH2-
3-2088	Sub-48	3，4-diClPh	-SO2-	Single bond	-CH2CH2-
						3-2089	Sub-37	4-ClPh	-SO2-	Single bond	-CH2CH2-
3-2090	Sub-38	4-ClPh	-SO2-	Single bond	-CH2CH2-
						3-2091	Sub-39	4-ClPh	-SO2-	Single bond	-CH2CH2-
3-2092	Sub-40	4-ClPh	-SO2-	Single bond	-CH2CH2-
						3-2093	Sub-41	4-ClPh	-SO2-	Single bond	-CH2CH2-
3-2094	Sub-42	4-ClPh	-SO2-	Single bond	-CH2CH2-
						3-2095	Sub-84	4-ClPh	-SO2-	Single bond	-CH2CH2-
3-2096	Sub-81	4-ClPh	-SO2-	Single bond	-CH2CH2-
						3-2097	Sub-48	4-ClPh	-SO2-	Single bond	-CH2CH2-
3-2098	Sub-37	4-FPh	-SO2-	Single bond	-CH2CH2-
						3-2099	Sub-38	4-FPh	-SO2-	Single bond	-CH2CH2-
3-2100	Sub-39	4-FPh	-SO2-	Single bond	-CH2CH2-
						3-2101	Sub-40	4-FPh	-SO2-	Single bond	-CH2CH2-
3-2202	Sub-41	4-FPh	-SO2-	Single bond	-CH2CH2-
						3-2103	Sub-42	4-FPh	-SO2-	Single bond	-CH2CH2-
3-2104	Sub-84	4-FPh	-SO2-	Single bond	-CH2CH2-
						3-2105	Sub-81	4-FPh	-SO2-	Single bond	-CH2CH2-
3-2106	Sub-48	4-FPh	-SO2-	Single bond	-CH2CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2107	Sub-37	3，4-diClPh	-SO2-	Single bond	-(CH2)3-
3-2108	Sub-38	3，4-diClPh	-SO2-	Single bond	-(CH2)3-
						3-2109	Sub-39	3，4-diClPh	-SO2-	Single bond	-(CH2)3-
3-2110	Sub-40	3，4-diClPh	-SO2-	Single bond	-(CH2)3-
						3-2111	Sub-41	3，4-diClPh	-SO2-	Single bond	-(CH2)3-
3-2112	Sub-42	3，4-diClPh	-SO2-	Single bond	-(CH2)3-
						3-2113	Sub-84	3，4-diClPh	-SO2-	Single bond	-(CH2)3-
3-2114	Sub-81	3，4-diClPh	-SO2-	Single bond	-(CH2)3-
						3-2115	Sub-48	3，4-diClPh	-SO2-	Single bond	-(CH2)3-
3-2116	Sub-37	4-ClPh	-SO2-	Single bond	-(CH2)3-
						3-2117	Sub-38	4-ClPh	-SO2-	Single bond	-(CH2)3-
3-2118	Sub-39	4-ClPh	-SO2-	Single bond	-(CH2)3-
						3-2119	Sub-40	4-ClPh	-SO2-	Single bond	-(CH2)3-
3-2120	Sub-41	4-ClPh	-SO2-	Single bond	-(CH2)3-
						3-2121	Sub-42	4-ClPh	-SO2-	Single bond	-(CH2)3-
3-2122	Sub-84	4-ClPh	-SO2-	Single bond	-(CH2)3-
						3-2123	Sub-81	4-ClPh	-SO2-	Single bond	-(CH2)3-
3-2124	Sub-48	4-ClPh	-SO2-	Single bond	-(CH2)3-
						3-2125	Sub-37	4-FPh	-SO2-	Single bond	-(CH2)3-
3-2126	Sub-38	4-FPh	-SO2-	Single bond	-(CH2)3-
						3-2127	Sub-39	4-FPh	-SO2-	Single bond	-(CH2)3-
3-2128	Sub-40	4-FPh	-SO2-	Single bond	-(CH2)3-
						3-2129	Sub-41	4-FPh	-SO2-	Single bond	-(CH2)3-
3-2130	Sub-42	4-FPh	-SO2-	Single bond	-(CH2)3-
						3-2131	Sub-84	4-FPh	-SO2-	Single bond	-(CH2)3-
3-2132	Sub-81	4-FPh	-SO2-	Single bond	-(CH2)3-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2133	Sub-48	4-FPh	-SO2-	Single bond	-(CH2)3-
3-2134	Sub-37	3，4-diClPh	-SO2-	Single bond	-CH2C(Me)2-
						3-2135	Sub-38	3，4-diClPh	-SO2-	Single bond	-CH2C(Me)2-
3-2136	Sub-39	3，4-diClPh	-SO2-	Single bond	-CH2C(Me)2-
						3-2137	Sub-40	3，4-diClPh	-SO2-	Single bond	-CH2C(Me)2-
3-2138	Sub-41	3，4-diClPh	-SO2-	Single bond	-CH2C(Me)2-
						3-2139	Sub-42	3，4-diClPh	-SO2-	Single bond	-CH2C(Me)2-
3-2140	Sub-84	3，4-diClPh	-SO2-	Single bond	-CH2C(Me)2-
						3-2141	Sub-81	3，4-diClPh	-SO2-	Single bond	-CH2C(Me)2-
3-2142	Sub-48	3，4-diClPh	-SO2-	Single bond	-CH2C(Me)2-
						3-143	Sub-37	4-ClPh	-SO2-	Single bond	-CH2C(Me)2-
3-2144	Sub-38	4-ClPh	-SO2-	Single bond	-CH2C(Me)2-
						3-2145	Sub-39	4-ClPh	-SO2-	Single bond	-CH2C(Me)2-
3-2146	Sub-4O	4-ClPh	-SO2-	Single bond	-CH2C(Me)2-
						3-2147	Sub-41	4-ClPh	-SO2-	Single bond	-CH2C(Me)2-
3-2148	Sub-42	4-ClPh	-SO2-	Single bond	-CH2C(Me)2-
						3-2149	Sub-84	4-ClPh	-SO2-	Single bond	-CH2C(Me)2-
3-2150	Sub-81	4-ClPh	-SO2-	Single bond	-CH2C(Me)2-
						3-2151	Sub-48	4-ClPh	-SO2-	Single bond	-CH2C(Me)2-
3-2152	Sub-37	4-FPh	-SO2-	Single bond	-CH2C(Me)2-
						3-2153	Sub-38	4-FPh	-SO2-	Single bond	-CH2C(Me)2-
3-2154	Sub-39	4-FPh	-SO2-	Single bond	-CH2C(Me)2-
						3-2155	Sub-40	4-FPh	-SO2-	Single bond	-CH2C(Me)2-
3-2156	Sub-41	4-FPh	-SO2-	Single bond	-CH2C(Me)2-
						3-2157	Sub-42	4-FPh	-SO2-	Single bond	-CH2C(Me)2-
3-2158	Sub-84	4-FPh	-SO2-	Single bond	-CH2C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2159	Sub-81	4-FPh	-SO2-	Single bond	-CH2C(Me)2-
3-2160	Sub-48	4-FPh	-SO2-	Single bond	-CH2C(Me)2-
						3-2161	Sub-37	3，4-diClPh	-SO2-	Single bond	-CH2-cPr-
3-2162	Sub-38	3，4-diClPh	-SO2-	Single bond	-CH2-cPr-
						3-2163	Sub-39	3，4-diClPh	-SO2-	Single bond	-CH2-cPr-
3-2164	Sub-40	3，4-diClPh	-SO2-	Single bond	-CH2-cPr-
						3-2165	Sub-41	3，4-diClPh	-SO2-	Single bond	-CH2-cPr-
3-2166	Sub-42	3，4-diClPh	-SO2-	Single bond	-CH2-cPr-
						3-2167	Sub-84	3，4-diClPh	-SO2-	Single bond	-CH2-cPr-
3-2168	Sub-81	3，4-diClPh	-SO2-	Single bond	-CH2-cPr-
						3-2169	Sub-48	3，4-diClPh	-SO2-	Single bond	-CH2-cPr-
3-2170	Sub-37	4-ClPh	-SO2-	Single bond	-CH2-cPr-
						3-2171	Sub-38	4-ClPh	-SO2-	Single bond	-CH2-cPr-
3-2172	Sub-39	4-ClPh	-SO2-	Single bond	-CH2-cPr-
						3-2173	Sub-40	4-ClPh	-SO2-	Single bond	-CH2-cPr-
3-2174	Sub-41	4-ClPh	-SO2-	Single bond	-CH2-cPr-
						3-2175	Sub-42	4-ClPh	-SO2-	Single bond	-CH2-cPr-
3-2176	Sub-84	4-ClPh	-SO2-	Single bond	-CH2-cPr-
						3-2177	Sub-81	4-ClPh	-SO2-	Single bond	-CH2-cPr-
3-2178	Sub-48	4-ClPh	-SO2-	Single bond	-CH2-cPr-
						3-2179	Sub-37	4-FPh	-SO2-	Single bond	-CH2-cPr-
3-2180	Sub-38	4-FPh	-SO2-	Single bond	-CH2-cPr-
						3-2181	Sub-39	4-FPh	-SO2-	Single bond	-CH2-cPr-
3-2182	Sub-40	4-FPh	-SO2-	Single bond	-CH2-cPr-
						3-2183	Sub-41	4-FPh	-SO2-	Single bond	-CH2-cPr-
3-2184	Sub-42	4-FPh	-SO2-	Single bond	-CH2-cPr-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2185	Sub-84	4-FPh	-SO2-	Single bond	-CH2-cPr-
3-2186	Sub-81	4-FPh	-SO2-	Single bond	-CH2-cPr-
						3-2187	Sub-48	4-FPh	-SO2-	Single bond	-CH2-cPr-
3-2188	Sub-37	3，4-diClPh	-SO2-	Single bond	-C(Me)2-
						3-2189	Sub-38	3，4-diClPh	-SO2-	Single bond	-C(Me)2-
3-2190	Sub-39	3，4-diClPh	-SO2-	Single bond	-C(Me)2-
						3-2191	Sub-40	3，4-diClPh	-SO2-	Single bond	-C(Me)2-
3-2192	Sub-41	3，4-diClPh	-SO2-	Single bond	-C(Me)2-
						3-2193	Sub-42	3，4-diClPh	-SO2-	Single bond	-C(Me)2-
3-2194	Sub-84	3，4-diClPh	-SO2-	Single bond	-C(Me)2-
						3-2195	Sub-81	3，4-diClPh	-SO2-	Single bond	-C(Me)2-
3-2196	Sub-48	3，4-diClPh	-SO2-	Single bond	-C(Me)2-
						3-2197	Sub-37	4-ClPh	-SO2-	Single bond	-C(Me)2-
3-2198	Sub-38	4-ClPh	-SO2-	Single bond	-C(Me)2-
						3-2199	Sub-39	4-ClPh	-SO2-	Single bond	-C(Me)2-
3-2200	Sub-40	4-ClPh	-SO2-	Single bond	-C(Me)2-
						3-2201	Sub-41	4-ClPh	-SO2-	Single bond	-C(Me)2-
3-2202	Sub-42	4-ClPh	-SO2-	Single bond	-C(Me)2-
						3-2203	Sub-84	4-ClPh	-SO2-	Single bond	-C(Me)2-
3-2204	Sub-81	4-ClPh	-SO2-	Single bond	-C(Me)2-
						3-2205	Sub-48	4-ClPh	-SO2-	Single bond	-C(Me)2-
3-2206	Sub-37	4-FPh	-SO2-	Single bond	-C(Me)2-
						3-2207	Sub-38	4-FPh	-SO2-	Single bond	-C(Me)2-
3-2208	Sub-39	4-FPh	-SO2-	Single bond	-C(Me)2-
						3-2209	Sub-40	4-FPh	-SO2-	Single bond	-C(Me)2-
3-2210	Sub-41	4-FPh	-SO2-	Single bond	-C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2211	Sub-42	4-FPh	-SO2-	Single bond	-C(Me)2-
3-2212	Sub-84	4-FPh	-SO2-	Single bond	-C(Me)2-
						3-2213	Sub-81	4-FPh	-SO2-	Single bond	-C(Me)2-
3-2214	Sub-48	4-FPh	-SO2-	Single bond	-C(Me)2-
						3-2215	Sub-37	3，4-diClPh	-SO2-	-CH2-	-CH2-
3-2216	Sub-38	3，4-diClPh	-SO2-	-CH2-	-CH2-
						3-2217	Sub-39	3，4-diClPh	-SO2-	-CH2-	-CH2-
3-2218	Sub-40	3，4-diClPh	-SO2-	-CH2-	-CH2-
						3-2219	Sub-41	3，4-diClPh	-SO2-	-CH2-	-CH2-
3-2220	Sub-42	3，4-diClPh	-SO2-	-CH2-	-CH2-
						3-2221	Sub-84	3，4-diClPh	-SO2-	-CH2-	-CH2-
3-2222	Sub-81	3，4-diClPh	-SO2-	-CH2-	-CH2-
						3-2223	Sub-48	3，4-diClPh	-SO2-	-CH2-	-CH2-
3-2224	Sub-37	4-ClPh	-SO2-	-CH2-	-CH2-
						3-2225	Sub-38	4-ClPh	-SO2-	-CH2-	-CH2-
3-2226	Sub-39	4-ClPh	-SO2-	-CH2-	-CH2-
						3-2227	Sub-40	4-ClPh	-SO2-	-CH2-	-CH2-
3-2228	Sub-41	4-ClPh	-SO2-	-CH2-	-CH2-
						3-2229	Sub-42	4-ClPh	-SO2-	-CH2-	-CH2-
3-2230	Sub-84	4-ClPh	-SO2-	-CH2-	-CH2-
						3-2231	Sub-81	4-ClPh	-SO2-	-CH2-	-CH2-
3-2232	Sub-48	4-ClPh	-SO2-	-CH2-	-CH2-
						3-2233	Sub-37	4-FPh	-SO2-	-CH2-	-CH2-
3-2234	Sub-38	4-FPh	-SO2-	-CH2-	-CH2-
						3-2235	Sub-39	4-FPh	-SO2-	-CH2-	-CH2-
3-2236	Sub-40	4-FPh	-SO2-	-CH2-	-CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2237	Sub-41	4-FPh	-SO2-	-CH2-	-CH2-
3-2238	Sub-42	4-FPh	-SO2-	-CH2-	-CH2-
						3-2239	Sub-84	4-FPh	-SO2-	-CH2-	-CH2-
3-2240	Sub-81	4-FPh	-SO2-	-CH2-	-CH2-
						3-2241	Sub-48	4-FPh	-SO2-	-CH2-	-CH2-
3-2242	Sub-37	3，4-diClPh	-SO2-	-CH2-	-CH2CH2-
						3-2243	Sub-38	3，4-diClPh	-SO2-	-CH2-	-CH2CH2-
3-2244	Sub-39	3，4-diClPh	-SO2-	-CH2-	-CH2CH2-
						3-2245	Sub-40	3，4-diClPh	-SO2-	-CH2-	-CH2CH2-
3-2246	Sub-41	3，4-diClPh	-SO2-	-CH2-	-CH2CH2-
						3-2247	Sub-42	3，4-diClPh	-SO2-	-CH2-	-CH2CH2-
3-2248	Sub-84	3，4-diClPh	-SO2-	-CH2-	-CH2CH2-
						3-2249	Sub-81	3，4-diClPh	-SO2-	-CH2-	-CH2CH2-
3-2250	Sub-48	3，4-diClPh	-SO2-	-CH2-	-CH2CH2-
						3-2251	Sub-37	4-ClPh	-SO2-	-CH2-	-CH2CH2-
3-2252	Sub-38	4-ClPh	-SO2-	-CH2-	-CH2CH2-
						3-2253	Sub-39	4-ClPh	-SO2-	-CH2-	-CH2CH2-
3-2254	Sub-40	4-ClPh	-SO2-	-CH2-	-CH2CH2-
						3-2255	Sub-4l	4-ClPh	-SO2-	-CH2-	-CH2CH2-
3-2256	Sub-42	4-ClPh	-SO2-	-CH2-	-CH2CH2-
						3-2257	Sub-84	4-ClPh	-SO2-	-CH2-	-CH2CH2-
3-2258	Sub-81	4-ClPh	-SO2-	-CH2-	-CH2CH2-
						3-2259	Sub-48	4-ClPh	-SO2-	-CH2-	-CH2CH2-
3-2260	Sub-37	4-FPh	-SO2-	-CH2-	-CH2CH2-
						3-2261	Sub-38	4-FPh	-SO2-	-CH2-	-CH2CH2-
3-2262	Sub-39	4-FPh	-SO2-	-CH2-	-CH2CH2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2263	Sub-40	4-FPh	-SO2-	-CH2-	-CH2CH2-
3-2264	Sub-41	4-FPh	-SO2-	-CH2-	-CH2CH2-
						3-2265	Sub-42	4-FPh	-SO2-	-CH2-	-CH2CH2-
3-2266	Sub-84	4-FPh	-SO2-	-CH2-	-CH2CH2-
						3-2267	Sub-81	4-FPh	-SO2-	-CH2-	-CH2CH2-
3-2268	Sub-48	4-FPh	-SO2-	-CH2-	-CH2CH2-
						3-2269	Sub-37	3，4-diClPh	-SO2-	-CH2-	-(CH2)3-
3-2270	Sub-38	3，4-diClPh	-SO2-	-CH2-	-(CH2)3-
						3-2271	Sub-39	3，4-diClPh	-SO2-	-CH2-	-(CH2)3-
3-2272	Sub-40	3，4-diClPh	-SO2-	-CH2-	-(CH2)3-
						3-2273	Sub-41	3，4-diClPh	-SO2-	-CH2-	-(CH2)3-
3-2274	Sub-42	3，4-diClPh	-SO2-	-CH2-	-(CH2)3-
						3-2275	Sub-84	3，4-diClPh	-SO2-	-CH2-	-(CH2)3-
3-2276	Sub-81	3，4-diClPh	-SO2-	-CH2-	-(CH2)3-
						3-2277	Sub-48	3，4-diClPh	-SO2-	-CH2-	-(CH2)3-
3-2278	Sub-37	4-ClPh	-SO2-	-CH2-	-(CH2)3-
						3-2279	Sub-38	4-ClPh	-SO2-	-CH2-	-(CH2)3-
3-2280	Sub-39	4-ClPh	-SO2-	-CH2-	-(CH2)3-
						3-2281	Sub-40	4-ClPh	-SO2-	-CH2-	-(CH2)3-
3-2282	Sub-41	4-ClPh	-SO2-	-CH2-	-(CH2)3-
						3-2283	Sub-42	4-ClPh	-SO2-	-CH2-	-(CH2)3-
3-2284	Sub-84	4-ClPh	-SO2-	-CH2-	-(CH2)3-
						3-2285	Sub-81	4-ClPh	-SO2-	-CH2-	-(CH2)3-
3-2286	Sub-48	4-ClPh	-SO2-	-CH2-	-(CH2)3-
						3-2287	Sub-37	4-FPh	-SO2-	-CH2-	-(CH2)3-
3-2288	Sub-38	4-FPh	-SO2-	-CH2-	-(CH2)3-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2289	Sub-39	4-FPh	-SO2-	-CH2-	-(CH2)3-
3-2290	Sub-40	4-FPh	-SO2-	-CH2-	-(CH2)3-
						3-2291	Sub-41	4-FPh	-SO2-	-CH2-	-(CH2)3-
3-2292	Sub-42	4-FPh	-SO2-	-CH2-	-(CH2)3-
						3-2293	Sub-84	4-FPh	-SO2-	-CH2-	-(CH2)3-
3-2294	Sub-81	4-FPh	-SO2-	-CH2-	-(CH2)3-
						3-2295	Sub-48	4-FPh	-SO2-	-CH2-	-(CH2)3-
3-2296	Sub-37	3，4-diClPh	-SO2-	-CH2-	-CH2C(Me)2-
						3-2297	Sub-38	3，4-diClPh	-SO2-	-CH2-	-CH2C(Me)2-
3-2298	Sub-39	3，4-diClPh	-SO2-	-CH2-	-CH2C(Me)2-
						3-2299	Sub-40	3，4-diClPh	-SO2-	-CH2-	-CH2C(Me)2-
3-2300	Sub-41	3，4-diClPh	-SO2-	-CH2-	-CH2C(Me)2-
						3-2301	Sub-42	3，4-diClPh	-SO2-	-CH2-	-CH2C(Me)2-
3-2302	Sub-84	3，4-diClPh	-SO2-	-CH2-	-CH2C(Me)2-
						3-2303	Sub-81	3，4-diClPh	-SO2-	-CH2-	-CH2C(Me)2-
3-2304	Sub-48	3，4-diClPh	-SO2-	-CH2-	-CH2C(Me)2-
						3-2305	Sub-37	4-ClPh	-SO2-	-CH2-	-CH2C(Me)2-
3-2306	Sub-38	4-ClPh	-SO2-	-CH2-	-CH2C(Me)2-
						3-2307	Sub-39	4-ClPh	-SO2-	-CH2-	-CH2C(Me)2-
3-2308	Sub-40	4-ClPh	-SO2-	-CH2-	-CH2C(Me)2-
						3-2309	Sub-41	4-ClPh	-SO2-	-CH2-	-CH2C(Me)2-
3-2310	Sub-42	4-ClPh	-SO2-	-CH2-	-CH2C(Me)2-
						3-2311	Sub-84	4-ClPh	-SO2-	-CH2-	-CH2C(Me)2-
3-2312	Sub-81	4-ClPh	-SO2-	-CH2-	-CH2C(Me)2-
						3-2313	Sub-48	4-ClPh	-SO2-	-CH2-	-CH2C(Me)2-
3-2314	Sub-37	4-FPh	-SO2-	-CH2-	-CH2C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2315	Sub-38	4-FPh	-SO2-	-CH2-	-CH2C(Me)2-
3-2316	Sub-39	4-FPh	-SO2-	-CH2-	-CH2C(Me)2-
						3-2317	Sub-40	4-FPh	-SO2-	-CH2-	-CH2C(Me)2-
3-2318	Sub-41	4-FPh	-SO2-	-CH2-	-CH2C(Me)2-
						3-2319	Sub-42	4-FPh	-SO2-	-CH2-	-CH2C(Me)2-
3-2320	Sub-84	4-FPh	-SO2-	-CH2-	-CH2C(Me)2-
						3-2321	Sub-81	4-FPh	-SO2-	-CH2-	-CH2C(Me)2-
3-2322	Sub-48	4-FPh	-SO2-	-CH2-	-CH2C(Me)2-
						3-2323	Sub-37	3，4-diClPh	-SO2-	-CH2-	-CH2-cPr-
3-2324	Sub-38	3，4-diClPh	-SO2-	-CH2-	-CH2-cPr-
						3-2325	Sub-39	3，4-diClPh	-SO2-	-CH2-	-CH2-cPr-
3-2326	Sub-40	3，4-diClPh	-SO2-	-CH2-	-CH2-cPr-
						3-2327	Sub-41	3，4-diClPh	-SO2-	-CH2-	-CH2-cPr-
3-2328	Sub-42	3，4-diClPh	-SO2-	-CH2-	-CH2-cPr-
						3-2329	Sub-84	3，4-diClPh	-SO2-	-CH2-	-CH2-cPr-
3-2330	Sub-81	3，4-diClPh	-SO2-	-CH2-	-CH2-cPr-
						3-2331	Sub-48	3，4-diClPh	-SO2-	-CH2-	-CH2-cPr-
3-2332	Sub-37	4-ClPh	-SO2-	-CH2-	-CH2-cPr-
						3-2333	Sub-38	4-ClPh	-SO2-	-CH2-	-CH2-cPr-
3-2334	Sub-39	4-ClPh	-SO2-	-CH2-	-CH2-cPr-
						3-2335	Sub-40	4-ClPh	-SO2-	-CH2-	-CH2-cPr-
3-2336	Sub-41	4-ClPh	-SO2-	-CH2-	-CH2-cPr-
						3-2337	Sub-42	4-ClPh	-SO2-	-CH2-	-CH2-cPr-
3-2338	Sub-84	4-ClPh	-SO2-	-CH2-	-CH2-cPr-
						3-2339	Sub-81	4-ClPh	-SO2-	-CH2-	-CH2-cPr-
3-2340	Sub-48	4-ClPh	-SO2-	-CH2-	-CH2-cPr-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2341	Sub-37	4-FPh	-SO2-	-CH2-	-CH2-cPr-
3-2342	Sub-38	4-FPh	-SO2-	-CH2-	-CH2-cPr-
						3-2343	Sub-39	4-FPh	-SO2-	-CH2-	-CH2-cPr-
3-2344	Sub-40	4-FPh	-SO2-	-CH2-	-CH2-cPr-
						3-2345	Sub-41	4-FPh	-SO2-	-CH2-	-CH2-cPr-
3-2346	Sub-42	4-FPh	-SO2-	-CH2-	-CH2-cPr-
						3-2347	Sub-84	4-FPh	-SO2-	-CH2-	-CH2-cPr-
3-2348	Sub-81	4-FPh	-SO2-	-CH2-	-CH2-cPr-
						3-2349	Sub-48	4-FPh	-SO2-	-CH2-	-CH2-cPr-
3-2350	Sub-37	3，4-diClPh	-SO2-	-CH2-	-C(Me)2-
						3-2351	Sub-38	3，4-diClPh	-SO2-	-CH2-	-C(Me)2-
3-2352	Sub-39	3，4-diClPh	-SO2-	-CH2-	-C(Me)2-
						3-2353	Sub-40	3，4-diClPh	-SO2-	-CH2-	-C(Me)2-
3-2354	Sub-41	3，4-diClPh	-SO2-	-CH2-	-C(Me)2-
						3-2355	Sub-42	3，4-diClPh	-SO2-	-CH2-	-C(Me)2-
3-2356	Sub-84	3，4-diClPh	-SO2-	-CH2-	-C(Me)2-
						3-2357	Sub-81	3，4-diClPh	-SO2-	-CH2-	-C(Me)2-
3-2358	Sub-48	3，4-diClPh	-SO2-	-CH2-	-C(Me)2-
						3-2359	Sub-37	4-ClPh	-SO2-	-CH2-	-C(Me)2-
3-2360	Sub-38	4-ClPh	-SO2-	-CH2-	-C(Me)2-
						3-2361	Sub-39	4-ClPh	-SO2-	-CH2-	-C(Me)2-
3-2362	Sub-40	4-ClPh	-SO2-	-CH2-	-C(Me)2-
						3-2363	Sub-41	4-ClPh	-SO2-	-CH2-	-C(Me)2-
3-2364	Sub-42	4-ClPh	-SO2-	-CH2-	-C(Me)2-
						3-2365	Sub-84	4-ClPh	-SO2-	-CH2-	-C(Me)2-
3-2366	Sub-81	4-ClPh	-SO2-	-CH2-	-C(Me)2-

Table 3(cont.)

Compound (I) A serial number.	R1	R2	A	B	E
						3-2367	Sub-48	4-ClPh	-SO2-	-CH2-	-C(Me)2-
3-2368	Sub-37	4-FPh	-SO2-	-CH2-	-C(Me)2-
						3-2369	Sub-38	4-FPh	-SO2-	-CH2-	-C(Me)2-
3-2370	Sub-39	4-FPh	-SO2-	-CH2-	-C(Me)2-
						3-2371	Sub-40	4-FPh	-SO2-	-CH2-	-C(Me)2-
3-2372	Sub-41	4-FPh	-SO2-	-CH2-	-C(Me)2-
						3-2373	Sub-42	4-FPh	-SO2-	-CH2-	-C(Me)2-
3-2374	Sub-84	4-FPh	-SO2-	-CH2-	-C(Me)2-
						3-2375	Sub-81	4-FPh	-SO2-	-CH2-	-C(Me)2-
3-2376	Sub-48	4-FPh	-SO2-	-CH2-	-C(Me)2-

Among the compounds listed above, the following compounds, i.e., compounds No.1-1025 to 1-1536, 2-1537 to 2-1728, 2-1825 to 2-19202-1969 to 2-2016, 2-2113 to 2-2160, 2-2257 to 2-2352, 3-1 to 3-64, and 3-97 to 3-160 are preferred.

More preferred are the compounds No.1-1089 to 1-1120, 1-1217 to 1-1280, 1-1313 to 1-1344, 1-1505 to 1-1536, 2-1825 to 2-1920, 2-1969 to 2-2016, 2-2257 to 2-2352, 3-5 to 3-11, 3-17, 3-18, 3-37 to 3-43, 3-49, 3-50, 3-101 to 3-107, 3-113, 3-114, 3-133 to 3-139, 3-145 and 3-146.

Still more preferred are the compounds No.1-1089 to 1-1120, 1-1313 to 1-1344, 2-1969 to 2-2016, 3-7, 3-8, 3-10, 3-11, 3-39, 3-40, 3-42, 3-43, 3-103,3-104, 3-106, 3-107, 3-135, 3-136, 3-138, and 3-139.

The most preferred compounds of the invention are:

1- {2- [5- (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4-phenylpiperidine-4-carboxamide;

1- {2- [5- (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide;

1- {2- [5- (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (2-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (3-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (4-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (4-chlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4-phenylpiperidine-4-carboxamide;

1- {2- [5- (4-chlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide;

1- {2- [5- (4-chlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (2-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (4-chlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (3-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (4-chlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (4-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (4-fluorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4-phenylpiperidine-4-carboxamide;

1- {2- [5- (4-fluorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide);

1- {2- [5- (4-fluorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (2-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (4-fluorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (3-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (4-fluorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (4-pyridyl) piperidine-4-carboxamide;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4-carboxamide;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4-N, N-dimethylformamide;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-phenyl-4 (pyrrol-1-ylcarbonyl) piperidine;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-morpholinocarbonyl-4-phenylpiperidine;

1- {2- [2- (4-chlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4-carboxamide;

1- {2- [2- (4-chlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide);

1- {2- [2- (4-fluorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4-carboxamide;

1- {2- [2- (4-fluorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide);

1- {2- [2- (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4-carboxamide;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide);

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ isobenzofuran-1 (3H), 4' -piperidine];

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine];

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]-2-oxide;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ isoquinoline-1 (2H), 4' -piperidin]-3(4H) -one;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl]ethyl } spiro [ isobenzofuran-1 (3H), 4' -piperidine];

1- {2- [2- (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine];

1- {2- [2- (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]-2-oxide;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl]ethyl } spiro [ isoquinoline-1 (2H), 4' -piperidin]-3(4H) -one;

1- {2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (5R) - (4-chlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (5R) - (4-fluorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (4-chlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (4-fluorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) hexahydro-1, 4-oxazepin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (4-chlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) hexahydro-1, 4-oxazepin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (4-fluorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) hexahydro-1, 4-oxazepin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3-isopropoxyphenylacetyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (4-chlorophenyl) -4- (3-isopropoxyphenylacetyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide; and

1- {2- [ (2R) - (4-fluorophenyl) -4- (3-isopropoxyphenylacetyl) morpholin-2 yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4-piperidine]- (2S) -oxide;

1- {2- [ (2R) - (3, 4-dichlorophenyl) -5, 5-dimethyl-4- (3, 4, 5) -trimethoxybenzoyl) -morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

the compounds of the present invention can be prepared according to known methods for preparing such compounds, for example, as shown in reaction schemes A and J below.

Reaction scheme A:wherein R is¹，R²A, B, D, E, G and L are as defined above.

X, X ', Y, Y ' and Y ' may be any group or atom capable of being eliminated as a nucleophilic residue, without particular limitation. Examples of preferred such groups and atoms include: halogen atoms such as chlorine, bromine and iodine atoms; trihalomethoxy, such as trichloromethoxy; alkylsulfonyloxy groups having 1 to 6 carbon atoms, such as methylsulfonyloxyand ethylsulfonyloxy; haloalkanesulfonyloxy having 1 to 6 carbon atoms, such as trifluoromethanesulfonyloxy and pentafluoroethanesulfonyloxy; and arylsulfonyloxy groups such as benzenesulfonyloxy, p-toluenesulfonyloxy and p-nitrobenzenesulfonyloxy. Among these groups, a halogen atom and an alkylsulfonyloxy group are preferable.

X may be bound to R¹⁰The bonds form single bonds. In this case, the compound of formula (III) becomes an acid anhydride.

The group represented by E' corresponds to the group represented by E, but the number of carbon atoms therein is one less than that in an alkylene or cycloalkane-1, 1-diylmethyl or cycloalkane-1, 1-di (ylmethyl) group having 1 to 4 carbon atoms.

The group represented by G' corresponds to the group represented by G, but the number of carbon atoms therein is one less than that in an alkylene group having 1 to 4 carbon atoms or an alkenylene group having 2 to 4 carbon atoms.

R¹⁰Represents a carboxyl protecting group which can be eliminated chemically, for example by hydrogenolysis, hydrolysis, electrolysis or photolysis. Examples of such protecting groups preferred in the reaction include:

alkyl groups having 1 to 6 carbon atoms, e.g. those at R⁵The examples listed in (1);

alkenyl groups having 2 to 6 carbon atoms such as vinyl, 1-propenyl, 2-propenyl, 1-methyl-1-propenyl, 2-methyl-2-propenyl, 2-ethyl-2-propenyl, 1-butenyl, 2-butenyl, 1-methyl-1-butenyl, 3-methyl-2-butenyl, 1-ethyl-2-butenyl, 3-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 1-ethyl-3-butenyl, 1-pentenyl, 2-pentenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-pentenyl, 1-methylalen-3-pentenyl, 2-methyl-3-pentenyl, 4-pentenyl, 1-methyl-4-pentenyl, 2-methyl-4-pentenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, and 5-hexenyl.

Alkynyl having 2 to 6 carbon atoms such as ethynyl, 2-propynyl, 1-methyl-2-propynyl, 2-butynyl, 1-methyl-2-butynyl, 1-ethyl-2-butynyl, 3-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 1-ethyl-3-butynyl, 2-pentynyl, 1-methyl-2-pentynyl, 4-methyl-2-pentynyl, 3-pentynyl, 1-methyl-3-pentynyl, 2-methyl-3-pentynyl, 4-pentynyl, 1-methyl-4-pentynyl, 2-methyl-4-pentynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, and 5-hexynyl groups;

haloalkyl having 1 to 6 carbon atoms as exemplified above for substituent α;

hydroxyalkyl groups such as hydroxymethyl, 2-hydroxyethyl, 2, 3-dihydroxypropyl, 3-hydroxypropyl, 3, 4-dihydroxybutyl, and 4-hydroxybutyl;

fatty acyl substituted alkyl groups such as an acetylmethyl group;

aralkyl radicals, such as those previously mentioned R⁵The examples listed in (1) and the like; and silyl groups such as those exemplified in the aforementioned ester groups.

R¹¹Represents a hydroxyl protecting group which can be removed by chemical means, such as hydrogenolysis, hydrolysis, electrolysis, or photolysis. Examples of preferred protecting groups such as hydroxyl include:

acyl (including alkanoyl, haloalkanoyl, alkoxyalkyl acyl, alkenylacyl and alkynoyl) groups, such as those described above for R⁵The examples listed in (1);

arylacyl (including halo-substituted, alkyl-substituted, alkoxy-substituted, nitro-substituted, alkoxycarbonyl-substituted and aryl-substituted aromatic acyl groups), such as those described above for R⁵The examples listed in (1);

tetrahydrofuran or tetrahydrothiopyran groups, such as those exemplified above for the ester groups;

tetrahydrofuran or tetrahydrothienyl, such as those exemplified above forthe ester group;

silyl groups such as those exemplified in the above ester groups;

alkoxymethyl groups such as those exemplified in the above ester groups;

substituted ethyl groups such as those exemplified in the above ester groups;

aralkyl radicals, such as those mentioned above for R⁵Examples of which are listed above;

alkoxycarbonyl groups such as those exemplified above for substituent α;

alkenyloxycarbonyl radicals, such as those exemplified above for the ester radical; and

an aralkyloxycarbonyl group such as those exemplified above for the ester group.

R¹²Represents a hydrogen atom or¹¹The hydroxyl protecting groups listed in (1). Step A1

In this step, the Friedel-Crafts reaction of the compound of the formula (II) with the acid derivative of the formula (III) is carried out in a solvent in the presence of a Lewis acid (step A1a), optionally with R when the acid derivative of the formula (III) is an acid anhydride¹⁰Esterifying the resulting free carboxylic acid group (step A1b), and then converting the carbonyl group by a Wittig reaction in a solvent in the presence of a baseExomethylene (step A1c), thus producing a compound of formula (IV). Step A1a

There is no particular restriction on the nature of the Lewis acid used in the Friedel-Crafts reaction, and any Lewis acid commonly used in this type of reaction may be used. Examples of such Lewis acids include: III (C)₁-C₆Alkyl) silyl triflates, such as trimethylsilyl triflate; aluminum salts such as aluminum chloride; tin salts, such as tin tetrachloride; zinc salts, such as zinc bromide; titanium salts, such astitanium tetrachloride; perchlorates, such as trimethylsilyl perchlorate or triphenylmethyl perchlorate. Among them, aluminum salts and titanium salts are preferable, and aluminum chloride is particularly preferable.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers such as diethyl ether, isopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitro compounds, such as nitromethane and nitrobenzene. Among them, halogenated hydrocarbons are particularly preferable.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the purposes of the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. In general, however, we carry out the reaction at a temperature in the range from-10 to 150 ℃ and preferably from 0 to 100 ℃. The reaction time may also vary over a wide time range, depending on many factors, such as, inter alia, the reaction temperature and the nature of the reagents and solvents used. However, assuming that the reaction is carried out under the above-mentioned preferable conditions, the reaction is generally carried out for 30 minutes to 24 hours, preferably 1 to 12 hours. Step A1b

When the esterification in this step is an alkylation reaction, the reaction can be completed by any of the following steps. Step A1b (i)

The resulting carboxylic acids may be used with formulaWherein:

R¹⁰is as defined above, and

x' represents a residue which can be eliminated as a nucleophile, such as a halogen atom (e.g., chlorine, bromine or iodine atom), an alkylcarbonacyloxy group having 1 to 6 carbon atoms (e.g., methanesulfonyloxy or ethanesulfonyloxy); haloalkanesulfonyloxy having 1 to 6 carbon atoms (e.g., trifluoromethanesulfonyloxy or pentafluoroethanesulfonyloxy); arylsulfonyloxy (e.g., benzenesulfonyloxy, p-toluenesulfonyloxy, or p-nitrobenzenesulfonyloxy).

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane or heptane; aromatic hydrocarbons such as benzene, toluene or xylene; halogenated hydrocarbons, such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene or dichlorobenzene; an ether; such as diethyl ether, isopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane or diglyme; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isopropyl ketone or cyclohexanone; nitriles, such as acetonitrile or isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone and hexamethylphosphoric triamide.

The reaction is generally and preferably carried out in the presence of a base. Likewise, there is no particular limitation on the nature of the base used, and any base that has been used in this type of reaction may be used here. Examples of such bases include: alkali metal carbonates, sodium carbonate, potassium carbonate and lithium carbonate; alkali metal bicarbonates, such as sodium bicarbonate, carbocyclic potassium bicarbonate and lithium bicarbonate; alkali metal hydrides such as lithium hydride, sodium hydride, potassium hydride; alkali metal hydroxides such as sodium hydroxide, potassium hydroxide, barium hydroxide, lithium hydroxide; alkali metal fluorides such as lithium fluoride, sodium fluoride and potassium fluoride; alkali metal alkoxides such as sodium methoxide, sodium ethoxide, potassium methoxide, potassium ethoxide, potassium tert-butoxide, and lithium methoxide; alkali metal mercaptides such as sodium methyl mercaptide and sodium ethyl mercaptide; organic bases, such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyridopyridine, picoline, 4- (N, N-dimethylamino) pyridine, 2, 6-di (tert-butyl) -4-methylpyridine, quinoline, N-dimethylaniline, N-diethylaniline, 1, 5-diazabicyclo [4, 3, 0]non-5-ene (DBN), 1, 4-diazabicyclo [2, 2, 2]octane (DABCO), 1, 8-diazabicyclo [5, 4, 0]undec-7-ene (DBU); and organometallic bases such as butyllithium, lithium diisopropylamide and lithium bis (trimethylsilyl) amide.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. In general, however, we carry out the reaction at a temperature in the range from-20 to 120 ℃ and preferably from 0 to 80 ℃. The reaction time may also vary over a wide time range, depending on many factors, such as, inter alia, the reaction temperature and the nature of the reagents and solvents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 0.5 to 10 hours. Step A1b (ii)

The resulting carboxylic acids may be used with formulaCompound of [ in which R¹⁰As defined above]The alkylation is accomplished using a condensation reagent reaction.

There are no particular restrictions on the nature of the condensing agent used, and any condensing agent which has been used in reactions of this type can be used here. Examples of such condensing agents include: (1) a combination of phosphate esters including (e.g., diphenylphosphoryl azide or diethylcyanophosphate) and one or more of the following bases; (2) carbodiimides (e.g., 1, 3-dicyclohexylcarbodiimide, 1, 3-diisopropylcarbodiimide or 1-2 yl-3- (3-dimethylaminopropyl) carbodiimide); a combination of one or more of the above carbodiimides and one or more of the following bases; or a combination of one or more of the above carbodiimides and an N-hydroxy compound (e.g., N-hydroxysuccinimide, 1-hydroxybenzotriazole or N-hydroxy-5-norbornene-2, 3-dicarboximide); (3) combinations of disulfides (e.g., 2, 2 '-dipyridyl disulfide or 2, 2' -dibenzothiazolyl disulfide, etc.) and phosphines (e.g., triphenylphosphine or tributylphosphine); (4) carbonates [ e.g. N, N-disuccinimidyl carbonate, di-2-pyridyl carbonate or S, S' -bis (1-phenyl-1H-tetrazol-5-yl) dithiocarbonate](ii) a (5) Phosphinophosphonic acid chlorides [ e.g., N, N' -bis (2-oxo-3-oxazolidinyl) phosphinic acid chloride phosphonic acid chloride](ii) a (6) Oxalate [ e.g., N, N '-disuccinimidyl oxalate, N, N' -diphosphthalimide oxalate, N, N '-bis (5-norbornene-2, 3-dienimiyl) oxalate, 1, 1' -bis (benzotriazolyl) oxalate, 1, 1 '-bis (6-chlorobenzotriazolyl) oxalate or 1, 1' -bis (6-trifluoromethylbenzotriazolyl) oxalate](ii) a (7) One or more of the above phosphines and one or more of azodicarboxylate or azodicarboxylate amide (e.g. diethyl azodicarboxylate, 1, 1' - (azodicarbonyl) dipiperidine]Or a mixture of one or more of the above phosphines with one or more of the following bases; (8) n-alkyl-5-aryl isoxazolium-3' -iodates with the alkyl moiety having 1-6 carbon atoms and the aryl moiety as defined above for R¹Examples of which are listed above. (e.g., N-ethyl-5-phenylisoxazolium-3' -sulfonate); (9) a diheterocyclic aryl diselenide (e.g., bis-2-pyridyl diselenide); (10) arylsulfonyltriazoles in which the aryl radical is as defined for R above¹Examples of which are listed above. (for example,p-nitrobenzenesulfonyltriazolate); (11) 2-halo-1-alkylpyridinium halides in which the alkyl moiety has 1 to 6 carbon atoms (e.g., 2-chloro-1-methylpyridinium iodide); (12) imidazoles (e.g., 1, 1 '-oxalyl diimidazole, N' -carbonyldiimidazole); (13) 3-alkyl-2-halo-benzothiazolium fluoroborates in which the alkyl moiety has 1 to 6 carbon atoms (e.g., 3-ethyl-2-chloro-benzothiazolium fluoroborate); (14) 3-alkylbenzothiazol-2-Serone wherein the alkyl moiety has 1 to 6 carbon atoms (e.g., 3-methylbenzothiazole-2-Serone); (15) phosphate esters (e.g., phenyl dichlorophosphate or polyphosphate) (16) halosulfonylisocyanates (e.g., chlorosulfonyl isocyanate); (17) halosilanes (e.g., trimethylsilyl chloride or triethylsilyl chloride); (18) combinations of alkyl sulfonyl halides having 1 to 6 carbon atoms (e.g., methanesulfonyl chloride) and one or more of the following bases; and (19) N, N, N ', N' -tetraalkylhaloformamidinium chlorides wherein each alkyl group has from 1 to 6 carbon atoms (e.g., N, N, N ', N' -tetramethylchloroformamidinium chloride).

Of these, we prefer compositions of carbodiimides or phosphines with azodicarboxylic acid esters or azodicarboxylic acid amides.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, so long as it does not adversely affect the reaction or the reagents used, and at leastsome amount of the reagents may be dissolved. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and glyme; nitriles such as acetonitrile and isobutyl nitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide.

Likewise, there is no particular limitation on the nature of the base used, and any base commonly used in this type of reaction may be used here. Examples of such bases include: organic bases, such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine, 2, 6-di (tert-butyl) -4-methylpyridine, quinoline, N, N-dimethylaniline, N, N-diethylaniline.

If desired, 4- (N, N-dimethylamino) pyridine or 4-pyrrolidinopyridine may be used in catalytic amounts, in combination with one or more other bases. If desired, the reaction may be carried out in the presence of one or more of the following reagents to enhance the efficiency of the reaction: a dehydrating agent (e.g., a molecular sieve), a quaternary ammonium salt (e.g., benzyltriethylammonium chloride or tetrabutylammonium chloride), a crown ether (e.g., dibenzo-18-crown-6), and an acid scavenger (e.g., 3, 4-dihydro-2H-pyrido [1, 2-a]pyrimidin-2-one).

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularlyrequired for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 80 ℃ and preferably 0 ℃ to room temperature. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 3 days, preferably 30 minutes to 1 day. Step A1b (iii)

The resulting carboxylic acid may be alkylated by reaction with the corresponding alcohol (e.g., methanol, ethanol, propanol, or butanol) to introduce a lower alkyl protecting group.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: the same alcohols as the reactants; aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane or glyme; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone or cyclohexanone; nitriles such as acetonitrile and isobutyl nitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) or hexamethylphosphoric triamide. Among them, the same alcohol as the reactant is preferable.

The reaction is carried out in the presence of an acid catalyst. Likewise, there is no particular limitation on the nature of the acid catalyst used, and any acid catalyst commonly used in this type of reaction may be used here. Examples of such acid catalysts include: bronsted acids such as inorganic acids (e.g., hydrochloric acid, hydrobromic acid, sulfuric acid, perchloric acid or phosphoric acid) and organic acids (e.g., acetic acid, formic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, trifluoroacetic acid or trifluoromethanesulfonic acid); and Lewis acids (e.g., boron trichloride, boron trifluoride, boron tribromide) or acid ion exchange resins.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of from 0 to 150 ℃ and preferably from 50 to 100 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 24 hours, preferably 30 minutes to 5 hours. Step A1c

In the Wittig reaction, too, there is no particular restriction on the nature of the Wittig reagent used, and any Wittig-type reagent commonly used in this type of reaction can be used here. Examples of such Wittig reagents include: methyl triphenyl halides such as methyl triphenyl phosphonium bromide and methyl triphenyl phosphonium iodide.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran; nitriles such as acetonitrile and isobutyl nitrile; amides such as formamide, dimethylformamide, dimethylacetamide, and hexamethylphosphoric triamide; and sulfoxides such as dimethyl sulfoxide and sulfolane. Among them, we prefer aromatic hydrocarbons, and particularly prefer benzene.

Likewise, there is no particular limitation on the nature of the base used, and any base commonly used in this type of reaction may be used here. Examples of such bases include: alkali metal carbonates such as sodium carbonate, potassium carbonate and lithium carbonate; alkali metal bicarbonates, such as sodium bicarbonate, potassium bicarbonate and lithium bicarbonate; alkali metal hydrides such as lithium hydride, sodium hydride, potassium hydride; alkali metal and alkaline earth metal hydroxides such as sodium hydroxide, potassium hydroxide, barium hydroxide and lithium hydroxide; alkali metal fluorides such as sodium fluoride, potassium fluoride; and alkali metal alcoholates such as sodium methylate, sodium ethylate, potassium methylate, potassium ethylate, potassium tert-butylate and lithium methylate. Among them, alkali metal hydrides and alkali metal alcoholates are preferred, and metal alcoholates are particularly preferred.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, thestarting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 100 ℃ and preferably 0 to 50 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the reagents and solvents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 24 hours, preferably 30 minutes to 12 hours. Step A2

In this step, the ester group in the compound of formula (IV) (prepared from step A1) is reduced in a solvent using a reducing agent to convert it to a primary hydroxyl group, and R is used¹¹The hydroxyl group is protected.

There is no particular limitation on the nature of the reducing agent used, and any reducing agent commonly used in this type of reaction may be used here. Examples of such reducing agents include: hydride reagents such as alkali metal borohydrides (e.g., sodium borohydride or lithium borohydride), aluminum hydride compounds (e.g., lithium aluminum hydride or lithium tri-t-butoxide hydride), sodium tellurite hydride, and organic aluminum hydride reducing agents [ e.g., diisobutylaluminum hydride or sodium bis (methoxyethoxy) aluminum hydride]. Among them, we prefer an aluminum hydride compound and an organic aluminum hydride reducing agent, and particularly prefer an aluminum hydride compound.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; and ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and glyme. Among them, we prefer ethers, and particularly prefer diethyl ether and tetrahydrofuran.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, the reaction is generally carried out at a temperature of-78 to 50 ℃ and preferably-20 to 20 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the reagents and solvents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 5 minutes to 24 hours, preferably 10 minutes to 2 hours.

The protecting group R may be introduced by any of the following methods¹¹. Step A2(i)

Can be used without protectionWith a suitable amount, preferably 1-4 equivalents (more preferably 2-3 equivalents), of a compound of the formulaCompound orCompound (in the latter compound)R¹¹Acyl) to introduce a protecting group R¹¹. Wherein the content of the first and second substances,

R¹¹as defined above, silyl groups are preferred, with tert-butyldimethylsilyl group being particularly preferred;

x' represents any group which can be eliminated as a nucleophilic residue, for example, a halogen atom such as a chlorine, bromine or iodine atom; an alkoxycarbonyloxy group such as a methoxycarbonyloxy group or an ethoxycarbonyloxy group having 1 to 6 carbon atoms in the alkoxy moiety; haloalkoyloxy having 2 to 6 carbon atoms, such as chloroacetyloxy, dichloroacetoxy, trichloroacetoxy or trifluoroacetyloxy; alkylsulfonyloxy groups having 1 to 6 carbon atoms, such as methanesulfonyloxy or ethanesulfonyloxy groups; haloalkanesulfonyloxy having 1 to 6 carbon atoms, such as trifluoromethanesulfonyloxy or pentafluoroethanesulfonyloxy; arylsulfonyloxy groups in which the aryl moiety is as above R¹Examples of the above-mentioned groups include benzenesulfonyloxy, p-toluenesulfonyloxy and p-nitrobenzenesulfonyloxy groups. Among them, we prefer a halogen atom, an alkylsulfonyloxy group and an arylsulfonyloxy group.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, so long as it does not adversely affect the reaction or the reagents used, and at least some of the reactants are soluble. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles such as acetonitrile and isobutyl nitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide. Among them, we prefer amides.

The reaction may be carried out in the presence of a base. Likewise, there is no particular limitation on the nature of the base used, and any base commonly used in this type of reaction may be used here. Examples of such bases include: organic bases, such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine, 2, 6-di (tert-butyl) -4-methylpyridine, imidazole, quinoline, N, N-dimethylaniline, N, N-diethylaniline. Among them, 4- (N, N-dimethylamino) pyridine is preferable.

Additionally, 4- (N, N-dimethylamino) pyridine or 4-pyrrolidinopyridine may be used in catalytic amounts, in combination with one or more other bases. If desired, the reaction may be carried out in the presence of one or more of the following reagents to enhance the efficiency of the reaction: quaternary ammonium salts (e.g., benzyltriethylammonium chloride or tetrabutylammonium chloride), crown ethers (e.g., dibenzo-18-crown-6).

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 100 ℃, preferably-10 to 50 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 1 day, preferably 30 minutes to 10 hours.

General formula (VII)Specific examples of the representative compounds include: acyl halides such as aliphatic acyl halides (e.g., acetyl chloride, propionyl chloride, butyryl chloride, valeryl chloride and hexanoyl chloride); alkoxycarbonyl halides having 1 to 6 carbon atoms in the alkoxy moiety (e.g., methoxycarbonyl chloride, methoxycarbonyl bromide, ethoxycarbonyl chloride, propoxycarbonyl chloride, butoxycarbonyl chloride and hexyloxycarbonyl chloride); aryl carbonylRadical halides (e.g., benzoyl chloride, benzoyl bromide, naphthoyl chloride); and silyl halides, and tert-butyldimethylsilyl chloride, trimethylsilyl chloride, triethylsilyl bromide, triisopropylsilyl chloride, dimethylisopropylsilyl chloride, diethylisopropylsilyl chloride, tert-butyldiphenylsilyl chloride, diphenylmethylsilyl chloride, triphenylsilyl chloride, or the corresponding silyl triflates; aralkyl halides such as benzyl chloride and benzyl bromide; carbonyloxyalkyl halides having from 1 to 6 carbon atoms in the alkyl moiety, such as pivaloyloxymethyl chloride and ethoxycarbonyloxymethyl chloride.

General formula (VII)Specific examples of the representative compounds include: aliphatic carboxylic anhydrides, such as acetic anhydride, propionic anhydride, valeric anhydride and hexanoic anhydride. Mixed anhydrides (e.g., of formic acid and acetic acid) may also be used. Step A2(ii)

By reacting an unprotected compound with a compound of formula[ wherein R¹¹Groups which are in acyl form include those defined above]The reaction of the compound (2) is carried out in a solvent in the presence of a condensing agent, which is exemplified by the above-mentioned step A1b (ii), and the reaction may be carried out in the presence or absence of a base, and a protecting group R may be introduced¹¹。

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does notadversely affect the reagents used in the reaction and can dissolve at least some amount of the reactants. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; nitriles such as acetonitrile and isobutyl nitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide.

The base used in step a2(ii) may be any of the bases listed in step a2 (i).

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 80 ℃ and preferably 0 ℃ to room temperature. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 3 days, preferably 30 minutes to 1 day. Step A2(iii)

By reacting an unprotected compound with a compound of formula[ wherein R¹¹Groups which are in acyl form include those defined above]In a solvent and in the presence of a dialkyl halophosphate (e.g., diethyl chlorophosphate) and a base, a protecting group R may be introduced¹¹。

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and can dissolve at least some of the reactants. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; quinones such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; nitriles such as acetonitrile and isobutyl nitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide.

The base used in step a2(iii) may be any of the bases listed in step a2 (i).

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, we carry out the reaction at a temperature ranging from 0 ℃ to the reflux temperature using the solvent, preferably from room temperature to 50 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 3 days, preferably 30 minutes to 1 day. Step A3

In this step, exomethylene group in the compound of formula (V) is oxidized in a solvent using an oxidizing agent to convert the compound into a diol form to prepare a compound of formula (VI).

Likewise, there is no particular limitation on the nature of the oxidizing agent used, and any oxidizing agent commonly used in this type of reaction may be used here. Examples of such oxidizing agents include: oxides of manganese, such as potassium permanganate and manganese dioxide; ruthenium oxides, such as ruthenium (IV) oxide; selenium compounds, such as selenium dioxide; and osmium compounds, e.g. osmium tetroxide and potassium osmate dihydrate: (). We prefer to use catalytic amounts of osmium tetroxide and reoxidant agents of osmium compounds. Examples of such reoxidants include: metal ferricyanides such as potassium ferricyanide (III); amine oxides such as 4-methylmorpholine oxide; inorganic oxidizing agents such as persulfate salts (e.g., potassium persulfate or sodium persulfate); peroxides, such as tert-butyl hydroperoxide; hypochlorite compounds such as tert-butyl hypochlorite; and nitrites, methyl nitrite. Among them, we prefer metal ferricyanides and amine oxides.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons, in particular halogenated aliphatic hydrocarbons, such as dichloromethane, chloroform; ethers such as diethyl ether, tetrahydrofuran, dioxane and dimethoxyethane; amides such as dimethylformamide, dimethylacetamide and hexamethylphosphoric triamide; sulfoxides, such as dimethyl sulfoxide; alcohols such as methanol, ethanol, propanol, isopropanol, butanol, isobutanol, tert-butanol and isoamyl alcohol; esters such as ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; dilute acids, such as aqueous sulfuric acid; dilute bases such as aqueous sodium hydroxide; water; ketones such as acetone and methyl ethyl ketone; organic bases, such as pyridine, nitriles, such as acetonitrile; or a mixture of any two or more of the above solvents. Among these, we prefer acetone and a mixture of acetone and water.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 80 ℃ and preferably 5 to 50 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 1 to 24 hours, preferably 2 to 12 hours.

An optically active diol derivative having a specific absolute configuration can be prepared by an asymmetric dihydroxylation reaction using a chiral ligand. This asymmetric dihydroxylation reaction can be carried out, for example, as described by Sharpless et al (chemical review, Vol.94, page2483 (1994)).

Examples of the oxidizing agent used for this reaction include 0.0001 to 0.1 equivalent (more preferably 0.001 to 0.005 equivalent) of osmium tetroxide. Examples of chiral ligands include hydrogenated quinidine 1, 4-phthalazinediyl diether (DHQD)2-PHAL) and hydrogenated quinidine 2, 5-diphenyl-4, 6-pyrimidinediyl diether (DHQD)2-PYR) (preferably (DHQD) 2-PHAL). Examples of the oxidizing agent used for reoxidizing the osmium compound include potassium ferricyanide (III) and potassium carbonate.

Examples of the solvent used include water and a mixture of one or more of the following organic solvents: halogenated hydrocarbons, in particular halogenated aliphatic hydrocarbons, such as dichloromethane, chloroform; ethers such as diethyl ether, tetrahydrofuran, dioxane and dimethoxyethane; amides such as dimethylformamide, dimethylacetamide and hexamethylphosphoric triamide; sulfoxides, such as dimethyl sulfoxide; alcohols such as methanol, ethanol, propanol, isopropanol, butanol, isobutanol, tert-butanol and isoamyl alcohol; ketones such as acetone and methyl ethyl ketone; an ester; such as ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; nitriles, such as acetonitrile; mixtures of water and alcohols are preferred. Among these, a mixture of water and t-butanol is particularly preferable.

The compound of formula (VI) wherein D represents a sulfur atom can be prepared by converting the exomethylene group of the compound of formula (V) into thiirane by a conventional method and then opening the ring with a hydroxyl ion. Step A4

In this step a compound of formula (VII) is prepared by: (a) converting the primary hydroxyl group in formula (VI) into an eliminable group (this reaction is carried out in the presence of a base, with or without a solvent); and (b) then reacting the resulting compound with an azidation reagent, the reaction being carried out in a solvent, with or without a catalyst, to convert it to an azido group.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons, particularly halogenated aliphatic hydrocarbons such as dichloromethane and chloroform; ethers such as diethyl ether, tetrahydrofuran, dioxane and dimethoxyethane; nitriles such as acetonitrile and amides such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone and hexamethylphosphoric triamide; more preferred are halogenated hydrocarbons or ethers in the first reaction step or amides in the second reaction step.

There is no particular limitation on the nature of the base used in the first step, and any base commonly used in this type of reaction may be used here. Examples of such bases include: organic bases, such as N-methylmorpholine, triethylamine, tripropylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine, 2, 6-di (tert-butyl) -4-methylpyridine, quinoline, N, N-dimethylaniline, N, N-diethylaniline, 1, 5-diazabicyclo [4, 3, 0]non-5-ene (DBN), 1, 4-diazabicyclo [2, 2, 2]octane (DABCO) and 1, 8-diazabicyclo [5, 4, 0]undec 7-ene (DBU). Among them, triethylamine, pyridine and 4- (N, N-dimethylamino) pyridine are preferable.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 50 ℃ and preferably 10 to 20 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature andthe nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 15 minutes to 24 hours, preferably 30 minutes to 6 hours.

Groups which can be eliminated are the same as those defined for X above. Reagents for forming the eliminating group, preferably corresponding halides, examples of such reagents include sulfonyl halides such as methanesulfonyl chloride and p-toluenesulfonyl chloride. The reaction may be carried out with introduction of a protecting group R¹¹The same conditions were used.

Likewise, there is no particular limitation on the nature of the azidation reagent used in the second step, and any azidation reagent commonly used in this type of reaction may be used here. Examples of such azidation reagents include: diarylphosphoryl azides, such as diphenylphosphoryl azide; trialkylsilyl azides, such as trimethylsilyl azide and triethylsilyl azide; and alkali metal azides such as sodium azide, potassium azide and lithium azide. Among them, we prefer alkali metal azides.

Examples of useful catalysts include trialkylsilyl triflates, such as trimethylsilyl triflate, trimethylsilyl triflate; lewis acids, such as boron trifluoride etherate, aluminum chloride and zinc chloride.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of 20 to 180 ℃, preferably 50 to 150 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 24 hours, preferably 30 minutes to 8 hours. Step A5

In this step, the amino compound of the general formula (VIII) is prepared by reducing the compound of the general formula (VII) in a solvent.

Any reagent that can reduce an azide group to an amino group can be used in the reaction, and is not particularly limited. Preferably, the reaction is carried out at 20 to 150 deg.C (more preferably 50 to 100 deg.C) for 15 minutes to 1 day (more preferably 1 to 12 hours), and the reaction is carried out in an aqueous solvent (preferably an ether such as tetrahydrofuran) using triphenylphosphine as a reducing agent.

In addition, the reaction may be carried out by catalytic hydrogenation at-10 to 100 ℃ (preferably 0 to 50 ℃) for 1 hour to 4 days (preferably 2 hours to 2 days), in an organic solvent such as an alcohol (e.g., methanol or ethanol), an ester (e.g., ethyl acetate, propyl acetate, butyl acetate or diethyl carbonate), an ether (e.g., tetrahydrofuran or dioxane) or a fatty acid (e.g., acetic acid) or a mixture of any one or more organic solvents with water (preferably an alcohol), using a catalyst such as palladium on carbon, platinum or Raney nickel. Step A6

In this step, a compound of the formula (X) is prepared, and the amino group in the compound of the formula (VIII) is acylated with a compound of the formula (IX) in a solvent in the presence of a base (step A6a), followed by ring closure of the alkylated DH group to form a cyclic amide (step A6 b). Step A6a

The acylation reaction in this step is generally and preferably carried out in a solvent. There is no particular limitation on the natureof the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; nitriles such as acetonitrile and isobutyl nitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide.

Likewise, there is no particular limitation on the nature of the base used, and any base commonly used in this type of reaction may be used here. Examples of such bases include: organic bases, such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine, 2, 6-di (tert-butyl) -4-methylpyridine, quinoline, N, N-dimethylaniline, N, N-diethylaniline.

If desired, 4- (N, N-dimethylamino) pyridine or 4-pyrrolidinopyridine may be used in catalytic amounts, in combination with one or more other bases. If desired, the reaction may be carried out in the presence of one or more of the following reagents to enhance the efficiency of the reaction: a dehydrating agent (e.g., a molecular sieve), a quaternary ammonium salt (e.g., benzyltriethylammonium chloride or tetrabutylammonium chloride), a crown ether (e.g., dibenzo-18-crown-6), and an acid scavenger (e.g., 3, 4-dihydro-2H-pyrido [1, 2-a]pyrimidin-2-one).

The reaction can be carried out over a widetemperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 80 ℃ and preferably 0 ℃ to room temperature. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 3 days, preferably 30 minutes to 1 day.

In the case where the group X' in the carboxylic acid derivative of the formula (IX) represents a hydroxyl group, the reaction is carried out by reacting the compound of the formula (VIII) with the compound of the formula (IX) in the presence of the condensing agent described in step A1b (ii) in the above-mentioned solvent in the presence or absence of the above-mentioned base. Step A6b

The cycloalkylation reaction in this step is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; nitriles such as acetonitrile, propionitrile, and isobutyl nitrile; amides such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide; and sulfoxides such as dimethyl sulfoxide and sulfolane. Among them, we prefer ethers and amides, and particularly prefer tetrahydrofuran and dimethylformamide.

Likewise, there is no particular limitation on the nature of the base used, and any base commonly used in this type of reaction may be used here. Examples of such bases include: alkali metal carbonates such as sodium carbonate, potassium carbonate and lithium carbonate; alkali metal bicarbonates, such as sodium bicarbonate, potassium bicarbonate and lithium bicarbonate; alkali metal hydrides such as lithium hydride, sodium hydride, potassium hydride; alkali metal hydroxides such as sodium hydroxide, potassium hydroxide, barium hydroxide and lithium hydroxide; alkali metal fluorides such as sodium fluoride, potassium fluoride; and alkali metal alcoholates such as sodium methylate, sodium ethylate, potassium methylate, potassium ethylate, potassium tert-butylate and lithium methylate. Among them, alkali metal hydrides and alkali metal alcoholates are preferred.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 100 ℃ and preferably 0 to 50 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the reagents and solvents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 24 hours, preferably 30 minutes to 12 hours. Step A7

In this step, the amide group in the general formula (X) is converted into an imino group by reducing it in a solvent using a reducing agent, and then optionally with the group R¹²Protection is carried out to prepare the compound of the general formula (XI).

The reaction is generally and preferably carried out in a solvent in the main step. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme. Among these, we prefer ethers, particularly diethyl ether or tetrahydrofuran.

Likewise, there is no particular limitation on the nature of the reducing agent used, and any reducing agent commonly used in this type of reaction may be used here. Examples of such reducing agents include: hydride reagents such as alkali metal borohydrides (e.g., sodium borohydride or lithium borohydride), aluminum hydride compounds (e.g., lithium aluminum hydride or lithium tri-t-butoxide hydride), sodium tellurite hydride and organic aluminum hydride reducing agents [ e.g., diisobutylaluminum hydride or sodium bis (methoxyethoxy) aluminum hydride]and borane reducing agents (e.g., borane-dimethyl sulfide complex, or borane-tetrahydrofuran complex, etc.). Among them, we prefer an aluminum hydride compound and a borane reducing agent, and particularly prefer a borane-dimethyl sulfide complex.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-78 to 150 ℃, preferably-20 to 100 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the reagents and solvents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 5 minutes to 24 hours, preferably 10 minutes to 2 hours. Step A8

In this step, a compound of the formula (XIII) is prepared by using the imino group of the formula (XI) with-A-B-R¹(A, B and R₁Same as defined above) is prepared by reacting a compound of formula (XI) with a compound of formula (XII) in a solvent in the presence of a base.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane and heptane, ligroin and petroleum ether; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; nitro compounds such as nitroethane and nitrobenzene; nitriles such as acetonitrile and isobutyl nitrile. Among them, halogenated hydrocarbons and ethers are preferable, and dichloromethane and tetrahydrofuran are particularly preferable.

Likewise, there is no particular limitation on the nature of the base used, and any base commonly used in this type of reaction may be used here. Examples of such bases include: organic bases, such as N-methylmorpholine, triethylamine, tripropylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine, 2, 6-di (tert-butyl) -4-methylpyridine, quinoline, N, N-dimethylaniline, N, N-diethylaniline, 1, 5-diazabicyclo [4, 3, 0]non-5-ene (DBN), 1, 4-diazabicyclo [2, 2, 2]octane (DABCO) and, 1, 8-diazabicyclo [5, 4, 0]undec-7-ene (DBU). Among them, triethylamine or diisopropylethylamine is preferable.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 100 ℃ and preferably 0 to 20 ℃. The reaction time may also vary within wide limits depending on many factors, the main reaction temperature and the nature of the reagents and solvents used, but, assuming that the reaction is carried out under the conditions described above, it is sufficient to carry out the reaction generally from 5 minutes to 24 hours, preferably from 10 minutes to 12 hours.

When A represents a carbonyl group, this step can also be carried out by reacting a compound of the formula (XI) with a compound of the formula(wherein A, B, R¹As defined above) is completed, the reaction is carried out in the presence of a condensing agent, in a solvent, with or without a base.

Examples of the condensing agent that can be used include those exemplified in the above-mentioned reaction step A1b (ii). Among these, we prefer a combination of phosphate and one or more of the following bases.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; nitriles such as acetonitrile and isobutyl nitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide.

Likewise, there is no particular limitation on the nature of the base used, and any base commonly used in this type of reaction may be used here. Examples of such bases include: organic bases, such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine, 2, 6-di (tert-butyl) -4-methylpyridine, quinoline, N, N-dimethylaniline and N, N-diethylaniline.

If desired, 4- (N, N-dimethylamino) pyridine or 4-pyrrolidinopyridine may be used in catalytic amounts, in combination with one or more other bases. If desired, the reaction may be carried out in the presence of one or more of the following reagents to enhance the efficiency of the reaction: a dehydrating agent (e.g., a molecular sieve), a quaternary ammonium salt (e.g., benzyltriethylammonium chloride or tetrabutylammonium chloride), a crown ether (e.g., dibenzo-18-crown-6), and an acid scavenger (e.g., 3, 4-dihydro-2H-pyrido [1, 2-a]pyrimidin-2-one).

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 80 ℃ and preferably 0 ℃ to room temperature. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 3 days, preferably 30 minutes to 1 day. Step A9

In this step, a compound of formula (XIV) is prepared by reacting R in a compound of formula (XIII)¹²(R¹²Not a hydrogen atom) and converting the resulting hydroxyl group into an eliminating group Y' which can be passed through the second step in step A4The one step method is completed.

Depending on the nature of the radical, R can be removed by different methods¹². However, methods for removing such groups are known in the art.

For example, when R is¹²When it is a silyl group, it is generally removed by treatment with a compound capable of forming a fluoride ion (e.g., tetrabutylammonium fluoride, hydrogen fluoride-pyridine or potassium fluoride), or with an organic acid (e.g., acetic acid, methanesulfonic acid, p-toluenesulfonic acid, trifluoromethanesulfonic acid or B-bromocatechol borane), or with an inorganic salt (e.g., hydrochloric acid).

When the group R¹²When removed by fluoride ion, the reaction may be accelerated by the addition of an organic acid such as formic acid, acetic acid or propionic acid.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; nitriles such as acetonitrile and isobutyl nitrile; water; and an organic acid, such as acetic acid, or a mixture of any two or more thereof.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of from 0 to 150 ℃, preferably from 10 to 150 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, the reaction is carried out for generally 1 to 48 hours, preferably 2 to 12 hours, sufficiently.

When R is¹²In the case of an aralkyl group or an aralkyloxy group, it is preferable to remove this group by contacting with a reducing agent (preferably catalytic hydrogenation in the presence of a catalyst at room temperature) in a solvent, or to use an oxidizing agent.

The catalytic hydrogenation reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: alcohols, such as methanol, ethanol, propanol; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran and dioxane; aromatic hydrocarbons such as benzene, toluene and xylene; aliphatic hydrocarbons such as hexane and cyclohexane; esters, such as ethyl acetate and propyl acetate; amides such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone and hexamethylphosphoric triamide; fatty acids such as formic acid and acetic acid; water; or a mixture of any two or more thereof. Among these, we prefer alcohols, mixtures of fatty acids and alcohols and ethers, mixtures of alcohols and water or mixtures of fatty acids and water.

Likewise, there is no particular limitation on the nature of the catalyst used, and any catalyst commonly used in this type of reaction may be used here. Examples of such catalysts include: palladium on carbon, palladium black, Raney nickel, platinum oxide, platinum black, alumina-rhodium, triphenylphosphine-rhodium chloride and palladium-barium sulfate.

The pressure of the reaction is not particularly limited, but the reaction is generally carried out in the range of 1 to 10 atmospheres.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, the reaction is generally carried out at a temperature of 0 to 100 ℃ and preferably20 to 70 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 5 minutes to 48 hours, preferably 1 to 24 hours.

If the protecting group is removed by oxidation, the reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Preferably, an aqueous organic solvent is used. Examples of suitable solvents include: ketones, such as acetone; halogenated hydrocarbons, preferably halogenated aliphatic hydrocarbons, such as dichloromethane, chloroform and carbon tetrachloride; nitriles, such as acetonitrile; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran and dioxane; amides such as dimethylformamide, dimethylacetamide and hexamethylphosphoric triamide; and sulfoxides, such as dimethyl sulfoxide.

Likewise, there is no particular limitation on the nature of the oxidizing agent used, and any oxidizing agent commonly used in this type of reaction may be used here. Examples of such oxidizing agents include: potassium persulfate, sodium persulfate, Cesium Ammonium Nitrate (CAN), and 2, 3-dichloro-5, 6-dicyano-p-benzoquinone (DDQ).

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature in the range of 0 to 150 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 24 hours.

It is also possible to remove the protecting group by reaction with an alkali metal (e.g., metallic lithium or metallic sodium) in liquid ammonia or with an alcohol (e.g., methanol or ethanol) at a temperature in the range of-78 to-20 ℃.

The protecting group may also be removed using reaction with aluminum chloride-sodium iodide or an alkylsilyl halide (e.g., trimethylsilyliodide) in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: nitriles, such as acetonitrile; halogenated hydrocarbons, preferably halogenated aliphatic hydrocarbons, such as dichloromethane, chloroform; or a mixture of any two or more thereof.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of 0 to 50 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 5 minutes to 3 days.

When the reaction substrate contains a sulfur atom, aluminum chloride-sodium iodide is preferably used.

When R is¹²When the group is an aliphatic acyl group, an aromatic acyl group or an alkoxycarbonyl group, the protecting group is preferably removed in a solvent using a base.

Likewise, there is no particular limitation on the nature of the base used, and any base commonly used in this type of reaction may be used here. Examples of such bases include: alkali metal alcoholates, such as sodium methylate; alkali metal carbonates such as sodium carbonate, potassium carbonate and lithium carbonate; alkali metal hydroxides such as sodium hydroxide, potassium hydroxide, lithium hydroxide and barium hydroxide; or various forms of ammonia such as aqueous ammonia or concentrated ammonia-methanol.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and can dissolve at least some amount of the reactants. Any solvent commonly used in this type of reaction may be used here. Examples of suitable solvents include: water; organic solvents such as alcohols (e.g., methanol, ethanol, propanol) and ethers (e.g., tetrahydrofuran and dioxane); or preferably a mixture of water and one or more of the above organic solvents.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in order to avoid side reactions, the reaction is generally carried out at a temperature of 0 to 150 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 1 to 10 hours.

When R is¹²When it is an alkoxymethyl group, a tetrahydropyranyl group, a tetrahydrothiopyranyl group, a tetrahydrofuranyl group, a tetrahydrothiofuranyl group or a substituted ethyl group, the protecting group is removed in a solvent using an acid.

Likewise, there is no particular limitation on the nature of the acid used, and any acid commonly used in this type of reaction may be used here. Examples of such acids include: bronsted acids such as mineral acids (e.g., hydrochloric acid, sulfuric acid, or nitric acid); organic acids (e.g., acetic acid, trifluoroacetic acid, methanesulfonic acid, or p-toluenesulfonic acid); and Lewis acids such as boron trifluoride. Strong acid ion exchange resins such as Dowex (trade mark) 50W may also be used.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane, heptane, ligroin and petroleum ether; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; alcohols, methanol, ethanol, propanol, isopropanol, butanol, isobutanol, tert-butanol, isoamyl alcohol, diethylene glycol, glycerol,octanol, cyclohexanol and methyl cellosolve; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; water; and mixtures of any one or more thereof. Among these, halogenated hydrocarbons, esters and ethers are preferred.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-10 to 100 ℃, preferably-5 to 50 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 5 minutes to 48 hours, preferably 30 minutes to 10 hours.

When R is¹²When it is an alkenyloxycarbonyl radical, it is preferred to use a base in combination with the removal of R¹²Is an aliphatic acyl group, an aromatic acyl group or an alkoxycarbonyl group, under the same conditions to remove R¹²。

In the case of allyloxycarbonyl, palladium and triphenylphosphine or bis (methyldiphenylphosphine) (1, 5-cyclooctadiene) -iridium (I) hexafluorophosphate can be used for removal, so that the reaction can be carried out simply and few side reactions occur. Step A10

In this step, the compound of the present invention of the general formula (I) is prepared by reacting the compound of the general formula (XIV) with the compound of the general formula (XV) in a solvent in the presence of a base.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane and heptane, ligroin and petroleum ether; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene, esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; nitro compounds such as nitroethane and nitrobenzene; nitriles such as acetonitrile and isobutyl nitrile; amides such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide; and sulfoxides such as dimethyl sulfoxide and sulfolane. Among them, we prefer amides, ethers, nitriles, and particularly prefer amides.

Likewise, there is no particular limitation on the nature of the base used, and any base commonly used in this type of reaction may be used here. Examples of such bases include: a combination of a metal iodide (e.g., potassium iodide) and an inorganic base, such as an alkali metal carbonate (e.g., sodium carbonate, potassium carbonate and lithium carbonate), an alkali metal hydrogencarbonate, (e.g., sodium hydrogencarbonate, potassium hydrogencarbonate and lithium hydrogencarbonate), an alkali metal hydride, (e.g., lithium hydride, sodium hydride, potassium hydride), an alkali metal hydroxide, (e.g., sodium hydroxide, potassium hydroxide, barium hydroxide and lithium hydroxide) or an alkali metal fluoride, (e.g., sodium fluoride or potassium fluoride); or an organic base such as N-methylmorpholine, triethylamine, tripropylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine, 2, 6-di (tert-butyl) -4-methylpyridinoquinoline, N, N-dimethylaniline, N, N-diethylaniline, 1, 5-diazabicyclo [4, 3, 0]non-5-ene (DBN), 1, 4-diazabicyclo [2, 2, 2]octane (DABCO) and 1, 8-diazabicyclo [5, 4, 0]undec-7-ene (DBU). Among them, we prefer a combination of a metal iodide and an inorganic base, and particularly prefer a combination of a metal iodide and an alkali metal bicarbonate.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of from 0 to 150 ℃, preferably from 20 to 120 ℃. The reaction time can also be within a wide range, depending on many factors, the main reaction temperature and the nature of the reagents and solvents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 30 minutes to 48 hours, preferably 1 to 12 hours.

After completion of the above-mentioned reaction steps, the reaction product can be collected from the reaction mixture using a conventional method.

For example, in one suitable separation method, the reaction mixture is neutralized, if insoluble, filtered to remove, and any water-immiscible solvent (e.g., ethyl acetate) is added. The organic layer is separated, and then washed with, for example, water, and the desired compound is dried using, for example, anhydrous magnesium sulfateor anhydrous sodium sulfate. The solvent was then distilled off to give the desired compound.

The resulting compound may, if desired, be purified by one or more of the following methods: recrystallizing; then precipitating; or other methods commonly used for separation and purification of organic compounds, for example, adsorption column chromatography using a chromatographic column, adsorption column chromatography using a carrier such as silica gel, alumina or magnesium-silica gel, Florisil; a partition column chromatography using a synthetic adsorbent, for example, Sephadex (trademark) LH-20 (manufactured by Pharmacia Co., Ltd.), Diaion (trademark) HP-20 (manufactured by Mitsubishi Kasei Co., Ltd.); methods using ion exchange chromatography; or normal/reverse phase liquid chromatography (preferably high performance liquid chromatography) using silica gel or alkylated silica gel.

When it is necessary to separate isomers, the separation can be carried out using the above separation and purification methods after completion of each reaction described above or after completion of the desired step. Reaction scheme B:

an alternative process for the preparation of compounds of the general formula (IV) is provided, after which the preparation of the compounds according to the invention can also be continued using step A.

In the above formula R²As defined above. Step B1

In this step, the compound of formula (IV) is prepared as follows: grignard reagents are prepared by reacting a compound of general formula (XVI) with magnesium metal according to the method described by Ito et al [ Bull. chem. Soc. Jpn., Vol.64, page 3746(1991)]; coupling the Grignard reagent with a compound of general formula (XVII) in a solvent, in the presence or absenceof a Lewis acid, and in the presence of a catalytic amount (preferably 0.1 to 0.5 equivalent) of a palladium catalyst; the resulting carboxylic acid was esterified according to any of the steps of step A1.

This is preferred because the reaction can be carried out in good yield in the presence of a Lewis acid with almost no by-products. There is no particular restriction on the nature of the Lewis acid used, and any Lewis acid commonly used in this type of reaction may be used here. Examples of such Lewis acids include: trialkylsilyl trifluoromethanesulfonate having 1 to 6 carbon atoms in the alkyl moiety; aluminum salts such as aluminum chloride; tin salts, such as tin tetrachloride; zinc salts, such as zinc bromide or zinc chloride; titanium salts, such as titanium tetrachloride; or perchlorate, trimethylsilyl perchlorate or triphenylmethyl perchlorate. Among them, zinc salts are preferable, and zinc chloride is particularly preferable.

Any palladium-containing palladium catalyst may be used without particular limitation. Preferred examples include organophosphinic palladium compounds such as dichlorobis (triphenylphosphine) palladium (II).

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and glyme. Among them, diethyl ether is preferred.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or thereagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 50 ℃ and preferably 0 to 20 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 15 minutes to 8 hours, preferably 30 minutes to 2 hours.

After completion of the above reaction, the desired compound of the formula (IV) can be isolated from the reaction mixture by a conventional method.

For example, in one suitable separation method, the reaction mixture is neutralized, if insoluble, filtered to remove, and any water-immiscible solvent (e.g., ethyl acetate) is added. The organic layer is separated, and then washed with, for example, water, and the resulting compound is dried using, for example, anhydrous magnesium sulfate or anhydrous sodium sulfate. The solvent was then distilled off to give the desired compound.

The resulting compound may, if desired, be purified by one or more of the following methods: recrystallizing; then precipitating; or other methods commonly used for the separation and purification of organic compounds, for example, using a carrier such as silica gel, alumina or magnesium-silica gel; florisil adsorption column chromatography; a partition column chromatography using a synthetic adsorbent, for example, Sephadex (trademark) LH-20 (manufactured by Pharmacia Co., Ltd.), Diaion (trademark) HP-20 (manufactured by Mitsubishi Kasei Co., Ltd.); using ion exchange chromatography; or normal/reverse phase liquid chromatography (preferably high performance liquid chromatography) using silica gel or alkylated silica gel. Scheme C

An alternative process for the preparation of compounds of the general formula (XI) is provided, after which the preparation of the compounds of the invention can also be continued using step A.

In the above formula R²，R¹¹，R¹²D, E and G are as defined above.

R¹³A hydrogen atom or a hydroxyl protecting group, and may be substituted with R as described above¹¹The groups listed in (a) are the same.

R¹⁴Represents an amino-protecting group, and examples thereof include aliphatic acyl groups, aromatic acyl groups, alkoxycarbonyl groups, alkenyloxycarbonyl groups, aralkyloxycarbonyl groups and silyl groups as defined below, with alkoxycarbonyl groups being preferred. Among these, tert-butoxycarbonyl is particularly preferable.

Step C1

In this step, the exomethylene group in the compound of the general formula (V) is reacted with an oxidizing agent in a solvent to prepare an epoxy compound of the general formula (XVIII).

Likewise, there is no particular limitation on the nature of the oxidizing agent used, and any oxidizing agent commonly used in olefin epoxidation reactions can be used here. Examples of such oxidizing agents include: peracids, such as m-chloroperbenzoic acid, 3, 5-dinitroperbenzoic acid, o-carboxyperbenzoic acid, peracetic acid, pertrifluoroacetic acid and perphthalic acid; a hydroperoxide; peroxides, such as t-butyl hydroperoxide (which may be used in combination with vanadium or molybdenum complexes); and a combination of a succinimide (e.g., N-bromosuccinimide) and a base. Among them, peracids are preferable, and m-chloroperbenzoic acid is particularly preferable.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons, particularly halogenated aliphatic hydrocarbons such as dichloromethane and chloroform; ethers, such as diethyl ether, tetrahydrofuran, dioxane, dimethoxyethane; amides such as dimethylformamide, dimethylacetamide and hexamethylphosphoric triamide; sulfoxides, such as dimethyl sulfoxide; alcohols such as methanol, ethanol, propanol, isopropanol, butanol, isobutanol, tert-butanol and isoamyl alcohol; dilute acids, such as aqueous sulfuric acid; dilute bases such as aqueous sodium hydroxide; water; ketones such as acetone and methyl ethyl ketone; organic bases, such as pyridine, nitriles, such as acetonitrile; or a mixture of any two or more of the above solvents. Among them, methylene chloride is preferred.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, the reaction is generally carried out at a temperature of-20 to 80 ℃ and preferably at a temperature of-5 to 50 ℃ to room temperature. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 1 to 24 hours, preferably 2 to 12 hours.

Optically active epoxy compounds having a specific absolute configuration can be prepared by asymmetric epoxidation using chiral ligands. This reaction can be carried out, for example, by Sharpless et al or by Jacobsen et al [ see catalysis A systematic Synthesis, VCH Publishers Inc. (1993) The process is complete. Step C2

In this step, the ring opening of the epoxide group in the compound of the formula (XVIII) is carried out using an amino alcohol of the formula (XIX) in the presence or absence of a base (step C2a) and the secondary ammonia is then protectedRadical-forming radicals R¹⁴(step C2b) to prepare a compound of formula (XX). Step C2a

The ring-opening reaction of the first step is generally preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; nitriles such as acetonitrile, propionitrile, and isobutyl nitrile; amides such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide; sulfoxides, such as dimethyl sulfoxide and sulfolane. Among them, we prefer nitrile.

Likewise, there is no particular limitation on the nature of the base used, and any base commonly used in this type of reaction may be used here. Examples of such bases include: alkali metal perchlorates such as lithium perchlorate and sodium perchlorate; alkali metal carbonates such as sodium carbonate, potassium carbonate and lithium carbonate; alkali metal bicarbonates, such as sodium bicarbonate, potassium bicarbonate and lithium bicarbonate; alkali metal hydrides such as lithium hydride, sodium hydride, potassium hydride; alkali metal hydroxides such as sodium hydroxide, potassium hydroxide, barium hydroxide and lithium hydroxide; alkali metal fluorides such as sodium fluoride, potassium fluoride; and alkali metal alcoholates such as sodium methylate, sodium ethylate, potassium methylate, potassium ethylate, potassium tert-butylate and lithium methylate; alkali metal mercaptides, such as sodium methyl mercaptide, sodium ethyl mercaptide; and organic bases such as N-methylmorpholine, triethylamine, tripropylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine, 2, 6-di (tert-butyl) -4-methylpyridine, quinoline, N, N-dimethylaniline, N, N-diethylaniline, 1, 5-diazabicyclo [4, 3, 0]non-5-ene (DBN), 1, 4-diazabicyclo [2, 2, 2]octane (DABC0) and 1, 8-diazabicyclo [5, 4, 0]undec-7-ene (DBI).

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 150 ℃ and preferably from room temperature to 100 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 3 days, preferably 30 minutes to 1 day. Step C2b

In this step, a secondary amino-protecting group R is introduced as follows¹⁴. Step C2b (i)

The unprotected compound is admixed with a suitable amount, for example, 1 to 4 equivalents (preferably 2 to 3 equivalents) of the compound of the formula in a solvent, in the presence or absence of a baseCompound (wherein R¹⁴As defined above, and X' represents a group capable of elimination as a nucleophilic residue, with special restrictions), or with the general formulaCompound of (2) (wherein R is¹⁴Selected from the group consisting of R as defined above¹⁴Acyl type group of (1). Examples of preferred such scavenging groups include: a halogen atom such as a chlorine, bromine or iodine atom; alkoxycarbonyloxy having 1 to 6 carbon atoms in the alkoxy moiety, such as methoxycarbonyloxy and ethoxycarbonyloxy; haloalkylcarbonyloxy having 1 to 6 carbon atoms in the alkyl moiety, such as chloroacetyloxy, dichloroacetoxy, trichloroacetoxy and trifluoroacetyloxy; alkylsulfonyloxy groups having 1 to 6 carbon atoms, such as methanesulfonyloxy and ethanesulfonyloxy groups; halogenated alkylsulfonyloxy groups having 1 to 6 carbon atoms, such as trifluoromethanesulfonyloxy and pentafluoroethanesulfonyloxy groups; arylsulfonyloxy groups in which the aryl moiety is as above R¹Examples of the above-mentioned groups include benzenesulfonyloxy, p-toluenesulfonyloxy and p-nitrobenzenesulfonyloxy groups. Among them, we prefer a halogen atom, a haloalkylsulfonyloxy group and an arylsulfonyloxy group.

General formula (VII)Specific examples of (a) include: acyl halides such as aliphatic acyl halides (e.g., acetyl chloride, propionyl chloride, butyryl chloride, valeryl chloride and hexanoyl chloride); in thatAlkoxycarbonyl halides in which the alkoxy moiety has 1 to 6 carbon atoms (e.g., methoxycarbonyl chloride, methoxycarbonyl bromide, ethoxycarbonyl chloride, propoxycarbonyl chloride, butoxycarbonyl chloride and hexyloxycarbonyl chloride); arylcarbonyl halides (e.g., benzoyl chloride, benzoyl bromide, naphthoyl chloride); silyl halides, such as tert-butyldimethylsilyl chloride, trimethylsilyl chloride, triethylsilyl bromide, triisopropylsilyl chloride, dimethylisopropylsilyl chloride, diethylisopropylsilyl chloride, tert-butyldiphenylsilyl chloride, diphenylmethylsilyl chloride, triphenylsilyl chloride or the corresponding silyl triflates; aralkyl halides such as benzyl chloride and benzyl bromide; or carbonyloxyalkyl halides, such as pivaloyloxymethyl chloride and ethoxycarbonyloxymethyl chloride.

General formula (VII)Specific examples of the representative compounds include: aliphatic carboxylic anhydrides, such as acetic anhydride, propionic anhydride or valeric anhydride, and carbonates, such as di-tert-butyl dicarbonate or hexanoic anhydride. Mixed anhydrides (e.g., a mixed anhydride of formic acid and acetic acid) may also be used.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane and heptane, ligroin and petroleum ether; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; nitriles such as acetonitrile and isobutyl nitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide.

Likewise, there is no particular limitation on the nature of the base used, and any base commonly used in this type of reaction may be used here. Examples of such bases include: organic bases, such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4- (N, N-dimethylamino) pyridine, 2, 6-di (tert-butyl) -4-methylpyridine, quinoline, N, N-dimethylaniline, N, N-diethylaniline.

If desired, 4- (N, N-dimethylamino) pyridine or 4-pyrrolidinopyridine may be used in catalytic amounts in combination with one or more other bases, and if desired, in the presence of one or more of the following reagents to enhance the efficiency of the reaction: quaternary ammonium salts (e.g., benzyltriethylammonium chloride or tetrabutylammonium chloride), crown ethers (e.g., dibenzo-18-crown-6).

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. In general, however, we carry out the reaction at temperatures ranging from-20 ℃ to the reflux temperature of the solvent used, preferably from 0 ℃ to room temperature. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 3 days, preferably 1 hour to 1 day. Step C2b (ii)

Unprotected compound with general formula (I) in solvent in the presence of condensing agent and in the presence or absence of base(wherein R is¹⁴Is selected from R as defined above¹⁴Acyl type group) of (a).

The condensing agents given above in step A1b (ii) may be used.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; nitriles such as acetonitrile and isobutyl nitrile; and amides such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide.

Bases which can be used in this step are the bases given above in step C2b (i).

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly critical to the present invention, and is preferably determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 80 ℃ and preferably 0 ℃ to room temperature. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 3 days, preferably 30 minutes to 1 day. Step C2b (iii)

Preferably, when R is¹⁴Is tert-butoxycarbonyl or benzyloxycarbonyl, by reacting the compound formed in step C1b with a tert-butoxycarbonylating agent or a benzyloxycarbonylating agent in a solvent in the presence of a base and then reacting with R¹⁴The group protects the secondary amino group.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; nitriles such as acetonitrile and isobutyl nitrile; amides such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide; water; and mixtures of water with any one or more of the above organic solvents.

Any of the bases given above for step C1C (i) may be used in this step.

Likewise, there is no particular limitation on the nature of the t-butyloxycarbonylating agent used, and any t-butyloxycarbonylating agent commonly used in reactions of this type may be used here. Examples of such t-butyloxycarbonylating agents include: di-tert-butyl dicarbonate, 2- (tert-butoxycarbonyloxyimino) -2-phenylacetonitrile, tert-butyl S- (4, 6-dimethylpyridin-2-yl) thiocarboxylate and 1, 2, 2, 2-tetrachloroethyl tert-butyl carbonate, more preferably di-tert-butyl dicarbonate.

Likewise, there is no particular limitation on the nature of the benzyloxycarbonylating reagent used, and any benzyloxycarbonylating reagent commonly used in this type of reaction can be used here. Examples of such benzyloxycarbonylation reagents include: benzyloxycarbonyl chloride, benzyloxycarbonyl cyanide and dibenzyl dicarbonate.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 80 ℃ and preferably 0 ℃ to room temperature. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 3 days, preferably 30 minutes to 24 hours. Step C3

In this step, the compound of formula (XXI) is prepared by dehydrating the compound of formula (XX) using a Mitsunobu reaction.

There is no particular limitation on the nature of the reagent used in the Mitsunobu reaction, and any reagent commonly used in this type of reaction may be used here. Examples of such agentsThe sub-steps include: compositions of azo compounds, such as dialkyl azodicarboxylates having 1-6 carbon atoms in the alkyl moiety (e.g., diethyl azodicarboxylate or diisopropyl azodicarboxylate) or azodicarbonyl compounds [ e.g., 1, 1- (azodicarbonyl) bipiperidine](ii) a And phosphines, e.g. triarylphosphines, wherein the aryl moiety is as R above¹A trialkyl phosphine (e.g., tributylphosphine) having 1 to 6 carbon atoms per alkyl moiety or (e.g., triphenylphosphine). Among these, we prefer a combination of dialkyl azodicarboxylate and triarylphosphine, and particularly prefer a combination of diethyl azodicarboxylate and triphenylphosphine.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; nitriles such as acetonitrile and isobutyl nitrile; amides such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide; and sulfoxides such as dimethyl sulfoxide and sulfolane. Among them, we prefer aromatic hydrocarbons and ethers.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 100 ℃ and preferably 0 to50 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 3 days, preferably 30 minutes to 12 hours.

In carrying out the reaction of this step, R is sometimes removed¹¹. In this case, the hydroxyl group may be re-protected as in the second part of step a 2. Step C4

In this step, the following steps are carried out simultaneously or separately to prepare the compound of formula (XI):

(i) removal of the amino-protecting group R¹⁴Exposing the amino group, and

(ii) when R is¹²In the case of a hydroxyl-protecting group, the hydroxyl group is optionally removed. Step C4(i)

The radical R can be removed by various reactions, depending on the nature of the radical¹⁴Reactions useful for removing such groups are known in the art. Step C4(i) a

For example, if the amino protecting group is a silyl group, the group is typically removed by treatment with a fluoride ion-forming compound, such as tetrabutylammonium fluoride.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: ethers, such as tetrahydrofuran or dioxane.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly requiredfor the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general we carry out the reaction at about room temperature. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 18 hours. Step C4(i) b

When the amino protecting group is an aliphatic acyl group, an aromatic acyl group, an alkoxycarbonyl group or a substituted methylene group to form a Sohiff base, it can be treated with an acid or a base in an aqueous solvent.

There are no particular restrictions on the nature of the acid used, and any acid commonly used in reactions of this type may be used here. Examples of such acids include: inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid and hydrobromic acid; and Lewis acids such as B-bromocatechol borane. Among them, B-bromocatechol borane or hydrochloric acid is preferable.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and can dissolve at least some amount of the reactants. Examples of suitable solvents include: aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and ethylene glycol dimethyl ether; nitro compounds, such as nitroethane and nitrobenzene. Among them, halogenated hydrocarbons are particularly preferable.

Likewise, there is no particular limitation on the nature of the base used, and any base commonly used in this type of reaction may be used here. Examples of such bases include: alkali metal alcoholates, such as sodium methylate; alkali metal carbonates such as sodium carbonate, potassium carbonate and lithium carbonate; alkali metal bicarbonates, such as sodium bicarbonate, potassium bicarbonate and lithium bicarbonate; alkali metal hydroxides such as sodium hydroxide, potassium hydroxide and lithium hydroxide; different forms of ammonia, such as aqueous ammonia and concentrated methanolic ammonia.

When a base is used for hydrolysis, isomerization sometimes occurs.

The reaction is preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, provided that it adversely affects the reaction or the reagents used, and that at least some amount of the reactants may be dissolved. Examples of suitable solvents include: water; organic solvents such as alcohols (e.g., methanol, ethanol or propanol) and ethers (e.g., tetrahydrofuran or dioxane); or a mixture of water and one or more of the above organic solvents.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature in the range of 0 to 150 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferable conditions, it is sufficient that the reaction is carried out for 1 to 10 hours in general. Step C4(i) C

When the amino protecting group is an aralkyl or aralkyloxycarbonyl group, we prefer to remove the protecting group by treatment with a reducing agent in a solvent (preferably catalytic hydrogenation at room temperature in the presence of a catalyst) or treatment with an oxidizing agent.

The catalytic hydrogenation reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: organic solvents such as alcohols (e.g. methanol, ethanol or isopropanol), ethers (e.g. diethyl ether, tetrahydrofuran or dioxane), aromatic hydrocarbons (e.g. benzene, toluene, xylene), esters (e.g. ethyl acetate or ethyl propyl acetate) and fatty acids (e.g. acetic acid) or mixtures of any one or more of these organic solvents with water.

Likewise, there is no particular limitation on the nature of the catalyst used in the catalytic hydrogenation reaction, and any catalyst commonly used in this type of reaction may be used here. Examples of such catalysts include: palladium on carbon, palladium black, Raney nickel, platinum oxide, platinum black, rhodium-aluminum oxide, triphenylphosphine-rhodium chloride and palladium-barium sulfate.

The pressure of the reaction is not particularly limited, and the reaction is generally carried out in the range of 1 to 10 atmospheres.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of 0 to 100 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for 1 to 24 hours in general.

The oxidation reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable organic solvents include: ketones, such as acetone; halogenated hydrocarbons, in particular aliphatic halogenated hydrocarbons, such as dichloromethane, chloroform and carbon tetrachloride; nitriles, such as acetonitrile; ethers such as diethyl ether, tetrahydrofuran and dioxane; amides such as dimethylformamide, dimethylacetamide and hexamethylphosphoric triamide.

Likewise, there is no particular limitation on the nature of the oxidizing agent used, and any oxidizing agent commonly used in this type of reaction may function here. Examples of such oxidizing agents include: potassium persulfate, sodium persulfate, Cesium Ammonium Nitrate (CAN) and 2, 3-dichloro-5, 6-dicyano-p-benzoquinone (DDQ).

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature in the range of 0 to 150 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and thenature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 24 hours. Step C4(i) d

When the amino protecting group is an alkenyloxycarbonyl group, the amino protecting group is preferably removed using a base which is treated under the same conditions as when the amino protecting group is an aliphatic acyl group, an aromatic acyl group or an alkoxycarbonyl group or a substituted methylene group to form a Schiff base.

In the case of allyloxycarbonyl, palladium and triphenylphosphine or nickel tetracarbonyl can be used for removal, so that the reaction can be carried out simply and few side reactions occur. Step C4(ii)

The removal of the group R can be carried out in the same manner as in step A9¹²。

After completion of the above-mentioned reaction steps, the desired reaction product can be collected from the reaction mixture using a conventional method.

For example, in one suitable separation method, the reaction mixture is neutralized, if insoluble, filtered off and a water-immiscible solvent (e.g., ethyl acetate) is added. The organic layer is separated, and then washed with, for example, water, and the resulting compound is dried using, for example, anhydrous magnesium sulfate or anhydrous sodium sulfate. The solvent was then distilled off to give the desired compound.

The resulting compound may, if desired, be purified by one or more of the following methods: recrystallizing; then precipitating; or other methods commonly used for the separation and purification of organic compounds, for example, adsorption column chromatography using a carrier such as silica gel, alumina or magnesium-silica gel, Florisil; partition column chromatography using a synthetic adsorbent, for example, Sephadex (trademark) LH-20 (manufactured by Pharmacia Co., Ltd.), Amberlite (trademark) XAD-11 (manufactured by Rohm&Hass Co., Ltd.), Diaion (trademark) HP-20 (manufactured by Mitsubishi Kasei Co., Ltd.); using ion exchange chromatography; or normal/reverse phase liquid chromatography (preferably high performance liquid chromatography) using silica gel or alkylated silica gel. Reaction scheme D

In this reaction scheme, the compound of formula (I) wherein E represents methylene is prepared from the compound of formula (VIII), i.e. the compound of formula (Ia) and the compound of formula (VIII)Can be prepared from the above reaction scheme a.Step D1

In this step, paraformaldehyde is reacted with the amino group and DH group in the compound of formula (VIII) in the presence or absence of an acid catalyst and in the presence or absence of a solvent to form an oxazolidine or thiazolidine ring, to prepare the compound of formula (XIa).

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane, heptane, ligroin and petroleum ether; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; nitro compounds such as nitroethane and nitrobenzene; nitriles such as acetonitrile and isobutyl nitrile; amides such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrollidone) and hexamethylphosphoric triamide; and sulfoxides such as dimethyl sulfoxide and sulfolane. Among them, we prefer aromatic hydrocarbons, and particularly prefer benzene and toluene.

Likewise, there is no particular limitation on the nature of the acid catalyst used, and any acid catalyst commonly used in this type of reaction may be used here. Examples of such acid catalysts include: bronsted acids such as inorganic acids (e.g., hydrochloric acid, hydrobromic acid, sulfuric acid, perchloric acid or phosphoric acid) and organic acids (e.g., acetic acid, formic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, camphorsulfonic acid, trifluoroacetic acid or trifluoromethanesulfonic acid). Among them, we prefer organic acids, and particularly prefer p-toluenesulfonic acid.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature in the range of 50 to 200 ℃ and preferably 80 to 150 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 30 minutes to 48 hours, preferably 1 to 12 hours. Steps D2, D3 and D4

Corresponding to steps A8, a9 and a10, respectively, and using the same reagents and reaction conditions, the compound of formula (Ia) is finally obtained.

The resulting compound may, if desired, be purified by one or more of the following methods: recrystallizing; then precipitating; or other methods commonly used for separation and purification of organic compounds, for example, adsorption column chromatography using a carrier such as silica gel, alumina or magnesium-silica gel, Florisil, using a synthetic adsorbent, for example, partition column chromatography using Sephadex (trademark) LH-20 (manufactured by phamaoi co.), Amberlite (trademark) XAD-11 (manufactured by Rohm&Hass co.), Diaion (trademark) HP-20 (manufactured by Mitsubishi Kasei co., ltd.); using ion exchange chromatography; or normal/reverse phase liquid chromatography (preferably high performance liquid chromatography) using silica gel or alkylated silica gel. Reaction scheme E

In this reaction scheme, a particularly preferred compound of the general formula (I) wherein L represents a fused ring system having a sulfoxide group wherein the sulfur atom is in the S configuration, that is, an optically active sulfoxide compound of the general formula (Ib) is produced.

In the above formula, Ar, R¹，R²A, B, D, E, J and Y are as defined above.

Represents a sulfoxide group in which the configuration of the sulfur atom is S configuration.

This reaction corresponds to step a10 and the same reagents and reaction conditions can be used to prepare compounds of general formula (Ib). Reaction scheme F

This reaction scheme provides an alternative method for preparing optically active sulfoxide compounds of the general formula (Ib).

In the above formula, R¹，R²A, B, D, E, G, J, Ar andas defined above. Step F1

In this step, the aldehyde derivative of the formula (XXIII) is prepared by oxidation of the alcohol derivative of the formula (XIIif). This reaction is generally carried out in a solvent in the presence of an oxidizing agent.

There is no particular limitation on the nature of the oxidation reaction used, and any reaction commonly used to oxidize primary alcohols to form aldehydes may be used herein. Examples of such oxidation reactions include: collins oxidation using pyridine and chromic acid in dichloromethane; PCC oxidation reaction using pyridinium chlorochromate (PCC) in dichloromethane; oxidation of Pyridinium Dichromate (PDC) in dichloromethane using PDC; DMSO oxidation reactions such as the Swem oxidation reaction in dichloromethane using electrophiles (e.g., acetic anhydride, trifluoroacetic anhydride, thionyl chlorosulfonyl chloride, oxalyl chloride, but cyclohexyl carbodiimide, diphenylketene-p-tolylimine, N-diethylaminoacetylene, sulfur trioxide and pyridine complex) and dimethyl sulfoxide (DMSO); and manganese dioxide oxidation using manganese dioxide in dichloromethane or benzene.

Preference is given to using the Swem oxidation in dichloromethane using oxalyl chloride and DMSO.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carriedout at a temperature ranging from-100 ℃ to room temperature, preferably from-78 ℃ to-20 ℃. The reaction time may also vary over a wide range, depending on a number of factors, mainly reflecting the temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 2 days, preferably 10 minutes to 6 hours. Step F2

In this step, an optically active sulfoxide derivative of the general formula (Ib) is prepared by subjecting a compound of the general formula (XXIII) and a compound of the general formula (XXII) to reductive amination.

Likewise, there is no particular limitation on the nature of the solvent used, so long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants can be dissolved. Examples of suitable solvents include: alcohols, such as methanol, ethanol, propanol; ethers, such as diethyl ether, tetrahydrofuran and dioxane. Among these, we prefer alcohols, particularly methanol or ethanol.

Likewise, there is no particular limitation on the nature of the reducing agent used, and any reducing agent commonly used in this type of reaction may function here. Examples of such reducing agents include: hydride reagents such as alkali metal borohydrides, e.g., sodium cyanoborohydride, sodium borohydride and lithium borohydride, aluminum hydride compounds, e.g., lithium aluminum hydride and lithium tri-t-butoxyaluminum hydride, sodium tellurium hydride and organic aluminum hydride reducing agents, e.g., diisobutylaluminum hydride and sodium bis (methoxyethoxy) aluminum hydride. Among these, we prefer alkali metal borohydride, and particularly prefer sodium cyanoborohydride.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-10 to 100 ℃ and preferably at room temperature to 80 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 2 days, preferably 1 to 6 hours. Reaction scheme G

There is provided an alternative process for the preparation of compounds of formula (XI) which are useful in the preparation of the compounds of the invention.In the above formula:

R²，R¹¹，R¹²，R¹³，R¹⁴d, E and G are as defined above; and this reaction scheme describes compounds of the general formula (XI) having 6-to 8-membered rings. Step G1

In this step, the primary hydroxyl group in the diol compound of the general formula (VI) is converted into an eliminated group (step G1a), and then substituted with an amino group in the amino alcohol compound of the general formula (XIX) to form a secondary amino group (step G1b), and then protected with an R14 group (step G1c), to prepare a compound of the general formula (XX). Step G1a

The primary hydroxyl group in the diol compound of formula (VI) may be converted to an eliminated group according to the first step in step A4. Step G1b

The substitution of the eliminated group in the resulting compound with the amino group in the aminoalcohol compound of the general formula (XIX) is usually carried out in a solvent using a metal salt.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; nitriles such as acetonitrile, propionitrile, and isobutyl nitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide. Among them, we prefer nitrile, and particularly prefer acetonitrile.

Likewise, there is no particular restriction on the nature of the metal salt used, and any metal salt commonly used in reactions of this type may function here. Examples of such metal salts include: metal perchlorates such as lithium perchlorate, magnesium perchlorate and sodium perchlorate; metal chlorides such as calcium chloride, zinc chloride and cobalt chloride; metal tetrafluoroborates such as lithium tetrafluoroborate, and potassium tetrafluoroborate; and zinc trifluoromethanesulfonate, preferably, a metal perchlorate, more preferably lithium perchlorate.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature isdetermined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 150 ℃ and preferably from room temperature to 100 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 30 minutes to 2 days, preferably 2 to 24 hours. Step G1c

The final use of R can be carried out according to the method described in step C2b¹⁴And (3) protecting an amino group. Step G2

In this step, the compound of the formula (XX) is subjected to a Mitsunobu reaction to dehydrate and ring-close it, to prepare a compound of the formula (XXI).

The reaction essentially uses the method described in step C3, and the same reagents and reaction conditions can be used.

It is to be noted that R¹¹And R¹⁴Can be eliminated in this step. In this case, if necessary, R may be used in accordance with the method of step G1c¹⁴Protecting imino; and the hydroxyl group can be replaced with R according to the method of steps A2(i) to (iii)¹¹And (4) protecting. Step G3

In this step, R in the compound of the formula (XXI) is removed¹²And R¹⁴Group (XI) preparation of the compound of formula (XI). This reaction may use essentially the method described in step C4, and the same reagents and reaction conditions may be used. Reaction scheme H

This reaction scheme illustrates a process for the preparation of compounds of formula (XXXII), which is a compound of formula (V) wherein G is two carbon atoms.

In the above formula, R²，R¹⁰And R¹¹As defined above;

R¹⁵represents an alkyl group having 1 to 6 carbon atoms, such as R⁵Examples listed in (b) are preferably methyl, ethyl, propyl and isopropyl, or two R¹⁵The radicals together represent an alkylene radical having 1 to 6 carbon atoms, preferably a methylene, ethylene or 1, 3-propylene radical; and is

W represents a halogen atom, particularly preferably a chlorine atom. Step H1

In this step, β -ketoester derivatives of formula (XXIX) are prepared from compounds of formula (XXVIII.) this reaction may be carried out according to conventional methods, for example, as described in J.Wemple et al [ Synthesis, 290(1993)]. step H2

In this step, β -ketoester derivatives of the formula (XXIX) and of the formulaAlcohol (R) of¹⁵As defined above) of the general formulaAlkane diol of (2)(wherein R is^15′Represents two R¹⁵Formed alkylene) or of the formulaOrthoformate of (R)¹⁵As defined above). The reaction can be carried out, for example, in an alcohol or an alkane diol with heating in the presence or absence of an acid catalyst.

General formula (VII)Examples of the alcohol of (b) include methanol, ethanol, propanol and isopropanol, with ethanol being preferred.

General formula (VII)Examples of the alkane diol of (2) include ethylene glycol, propylene glycol.

General formula (VII)Examples of the orthoformate of (b) include trimethoxymethane and triethoxymethane, preferably triethoxymethane.

This step can be carried out by heating in ethanol in the presence of ethyl orthoformate using p-toluenesulfonic acid as catalyst.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature in the range of 40 to 150 ℃ and preferably 50 to 100 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 30 minutes to 2 days, preferably 2 to 12 hours. Step H3

In this step, the ester of formula (XXX) is reduced to form a primary hydroxyl group, the ketal group is deprotected and then treated with R¹¹Protecting the primary hydroxyl group with a group to prepare a compound of formula (XXXI).

The reaction to reduce the orthoester is essentially the same as the first step in step a2, and the same reagents and reaction conditions can be used.

The deprotection of the ketal group is generally carried out in a solvent in the presence of an acid, preferably in the presence of trifluoroacetic acid in chloroform.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, the reaction is generally carried out at a temperature of-20 to 100 ℃, preferably-10 ℃ to room temperature, and the reaction time can also be in a wide range, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 24 hours, preferably 30 minutes to 2 hours.

The reaction for protecting the primary hydroxyl group can be carried out according to the method of steps A2(i) to (iii), preferably according to the method of step A2 (i). Step H4

In this step, a compound of formula (XXXI) is subjected to a Wittig reaction in a solvent in the presence of a base to convert the carbonyl group therein to an exomethylene group to produce a compound of formula (XXXII). The reaction for this step is essentially the same as for step A1c, and the same reagents and reaction conditions can be used. Reaction scheme I

In the above formula, G, R²And R¹¹As defined above.

This is another method for preparing the compound of formula (V), which can be used in reaction scheme A or C. Step I1

In this step, the compound of the general formula (XVI) is reacted with metallic magnesium using any conventional method to prepare a Grignard reagent, and then the above Grignard reagent is subjected to a cross-coupling reaction with thecompound of the general formula (XXXIII) and palladium or nickel is used as a catalyst to prepare the compound of the general formula (V).

There is no particular limitation on the nature of the palladium catalyst used, and any palladium catalyst commonly used in this type of reaction may be used here. Examples of such palladium catalysts include: tetrakis (diphenylphosphino) palladium (o) (tetrakis (triphenylphosphine) palladium (o)), bis (acetonitrile) palladium (II) chloride, bis (triphenylphosphine) palladium (II) chloride, [1, 1-bis (triphenylphosphine) -ferrocene]palladium (II) chloride, tris (dibenzylideneacetone) dipalladium (0), [1, 2-bis (diphenylphosphino) ethane]palladium (II) dichloride and palladium (II) acetate.

There is no particular limitation on the nature of the nickel catalyst used, and any nickel catalyst commonly used in this type of reaction may be used here. Examples of such nickel catalysts include: bis (triphenylphosphine) nickel (II) chloride, [1, 3-bis (diphenylphosphino) propane]nickel (II) chloride and palladium (II) acetoacetate.

The reaction is preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme, particular preference being given to diethyl ether and tetrahydrofuran.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at atemperature of 0 to 120 ℃ and preferably from room temperature to 80 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 24 hours, preferably 30 minutes to 5 hours. Reaction scheme J

This reaction scheme illustrates a method for preparing an optically active sulfoxide compound of the general formula (XXII) as a starting material in reaction scheme E.

In the above formula:

R¹⁴j, ring Ar and formulaAs defined above.

Q represents a hydroxyl group or a halogen atom such as a chlorine, bromine, iodine or fluorine atom; and is

Q represents a halogen atom, preferably a bromine atom. Step J1

In this step, a compound of formula (XXXV) is prepared from a compound of formula (XXXIV). Step J1a

When Q is hydroxy, this step may be accomplished by converting the hydroxy group in the compound of formula (XXXIV) to an acetylthio group and then hydrolyzing the acetylthio group with a base to remove the acetyl group.

The first step of the reaction can be accomplished by:

(a) converting the hydroxy group in the compound of formula (XXXIV) to an eliminated group and then reacting the eliminated group with a thioacetate salt; or

(b) The mitussubu reaction was performed using thioacetic acid.

The conversion of the hydroxyl group into an eliminated group in the reaction (a) may be carried out according to the latter reaction of step A9; the thioacetyl substitution is generally accomplished by reaction with a thioacetate in a solvent.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone or cyclohexanone; nitriles such as acetonitrile, propionitrile, and isobutyl nitrile; and amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) or hexamethylphosphoric triamide. Among them, we prefer amides, and particularly prefer dimethylformamide.

Examples of thioates that can be used in this reaction include lithium thioacetate, sodium thioacetate and potassium thioacetate.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 150 ℃ and preferably from room temperature to 100 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 30 minutes to 2 days, preferably 2 hours to 24 hours.

The Mitsunobu reaction of (b) can be carried out in the same manner as in step C3, except that a compound of formula (XXXIV) and thioacetic acid are used.

The reaction for eliminating the acetyl moiety in the acetylthio group can be accomplished by treatment with a base in a solvent.

Likewise, there is no particular limitation on the nature of the base used, and any base commonly used in this type of reaction may be used here. Examples of such bases include: metal alcoholates, such as sodium methylate; alkali metal carbonates such as sodium carbonate, potassium carbonate and lithium carbonate; alkali metal and alkaline earth metal hydroxides, such as sodium hydroxide, potassium hydroxide and lithium hydroxide and barium hydroxide; and different forms of ammonia such as aqueous ammonia and concentrated methanolic ammonia.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, and any solvent that has been used in the hydrolysis reaction may be used as long as it does not adversely affect the reaction or the reagents used, and can dissolve at least some amount of the reactants. Examples of suitable solvents include: water; organic solvents, for example alcohols (such as methanol, ethanol and propanol), ethers (such as tetrahydrofuran or dioxane) or mixtures of water with any one or more of these organic solvents.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature in the range of 0 to 150 ℃. The reaction time can also vary over a wide range, depending on a number of factors. The main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 1 to 10 hours. Step J1b

When Q is a halogen atom, the compound of formula (XXXIV) and thiourea may be heated in a solvent to react them, followed by hydrolysis to complete the reaction.

This reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: alcohols such as methanol, ethanol or isopropanol.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, the reaction is generally carried out at a temperature ranging from room temperature to 150 ℃, preferably from 50 ℃ to 100 ℃ to room temperature. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 30 minutes to 4 days,preferably 12 hours to 24 hours.

The hydrolysis reaction of the latter step is generally carried out in a mixture of water and any one of the above formulae and several alcohols.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, the reaction is generally carried out at a temperature ranging from room temperature to 150 ℃, preferably from 50 ℃ to 100 ℃ to room temperature. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 30 minutes to 6 hours, preferably 30 minutes to 2 hours. Step J2

In this step, a compound of formula (XXXV) is reacted with a compound of formula (XXXVI) in the presence of a base in a solvent to produce a compound of formula (XXXVII).

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diglyme; nitriles such as acetonitrile and isobutyl nitrile;amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) and hexamethylphosphoric triamide. Among them, we prefer ethers, and particularly prefer tetrahydrofuran.

Likewise, there is no particular limitation on the nature of the base used, and any base commonly used in this type of reaction may be used here. Examples of such bases include: alkali metal hydrides such as lithium hydride, sodium hydride, potassium hydride; and organometallic bases such as butyllithium, sec-butyllithium, tert-butyllithium, lithium diisopropylamide and lithium bis (trimethylsilyl) amide. Among these, we prefer an organometallic base, particularly preferably butyl lithium.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-100 to 100 ℃, preferably-78 to 0 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 0.5 to 10 hours, preferably 1 to 6 hours. Step J3

In this step, the compound of formula (XXXVII) is dehydrated to ring closure in the presence of an acid with or without a solvent to prepare the compound of formula (XXXVIII).

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagentsused, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: alcohols such as methanol and ethanol; aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane or diglyme; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone or cyclohexanone; nitriles such as acetonitrile and isobutyl nitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidone (pyrrolidone) or hexamethylphosphoric triamide. Among them, methanol and ethanol are preferred.

Likewise, there is no particular limitation on the nature of the acid used, and any acid commonly used in this type of reaction may be used here. Examples of such acids include: bronsted acids such as inorganic acids (e.g., hydrochloric acid, hydrobromic acid, sulfuric acid, perchloric acid or phosphoric acid) and organic acids (e.g., acetic acid, formic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, trifluoroacetic acid or trifluoromethanesulfonic acid); and Lewis acids such as boron trichloride, boron trifluoride, boron tribromide, or acid ion exchange resins. Among them, inorganic acids are preferable, and sulfuric acid is particularly preferable.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of from 0 to 150 ℃, preferably from 50 to 120 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 24 hours, preferably 5 hours to 24 hours. Step J4

In this step, optically active sulphoxide compounds of the general formula (XXXIX) are prepared from compounds of the general formula (XXXVIII)

(a) By direct asymmetric oxidation of compounds of the general formula (XXXVIII) or

(b) The compound of formula (XXXVIII) is oxidized and then optically resolved using a diastereomeric method.

(a) Wherein the asymmetric oxidation of the sulfoxide compound is prepared from a sulfide, is a method using an optically active oxidizing agent, is a chemical method using a combination of an optically active ligand and an oxidizing agent, or is a biological method using baker's yeast and microorganisms. Such asymmetric oxidations are described, for example, in the following references.

1)G.Solladie，Synthesis 185(1981)；

2)K.K.Andersen，The Chemistry of Sulfones and Sulfoxides：S.Patai，Z.Rappoport，C.J.M.Stirling.，Eds.Wiley&Sons，Ltd.，Chichester，England，1988，Chapter 3，pp 55-94：G.H.Posner.，ibid，Chapter 16，pp 823-849；

3)H.B.Kagan et al.，Synlett 643(1990)；

4)H.B.Kagan，Asymmetric Oxidation of Sulfides in CatalyticAsymmetric Synthesis 1，Ojima Ed.VCH，pp 203-226(1993)；

5)F.A.Davis et al.，J.Am.Chem.Soc.，114，1428(1992)。

Among them, the asymmetric oxidation preferably uses (3S, 2R) - (-) -N-phenylsulfonyl) (3, 3-dichlorocamphoryl) oxazolidine or (+) - [ (8, 8-dimethoxycamphoryl) sulfonyl]oxazolidine reported by F.A. Davis et al.

The asymmetric oxidation method is used according to f.a. davis et al, and the reaction is preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and can dissolve at least some amount of the reactants. Examples of suitable solvents include: water; alcohols such as methanol, ethanol, propanol, isopropanol, butanol, isobutanol and isoamyl alcohol; aliphatic hydrocarbons such as hexane and heptane; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters such as ethyl formate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane or diglyme; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone or cyclohexanone; nitriles such as acetonitrile and isobutyl nitrile; and pyridine.

The reaction can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-50 to 50 ℃ and preferably at a temperature of-20 ℃ to room temperature. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 10 minutes to 3 days, preferably 2 hours to 1 day.

(b) When the diastereomer method is used for optical resolution, first, the compound of the general formula (XXXVIII) is oxidized to synthesize a racemate of a sulfoxide derivative using a conventional method. Then, the protecting group is removed as described in step C4(i) to give an optically active sulfoxide derivative (XXXIX), which is then salified using an appropriate optically active carboxylic acid as an optical resolving agent and subjected to fractional recrystallization.

The oxidation in the preceding step is carried out with an oxidizing agent with or without a solvent.

Also, there is no particular limitation on the nature of the oxidizing agent used, and any oxidizing agent commonly used for oxidizing sulfides to prepare sulfoxide compounds can be used here. Examples of such oxidizing agents include: peracids, such as m-chloroperbenzoic acid, 2, 5-dinitroperbenzoic acid, o-carboxyperbenzoic acid, peracetic acid, pertrifluoroacetic acid and perphthalic acid; and succinimides such as, for example, N-bromosuccinimide and a base. Among them, peracids are preferable, and m-chloroperbenzoic acid is particularly preferable.

The reaction is generally and preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used, as long as it does not adversely affect the reaction or the reagents used, and at least some amount of the reactants may be dissolved. Examples of suitable solvents include: aromatic hydrocarbons such as benzene, toluene and xylene; a halogenated hydrocarbon; such as dichloromethane, chloroform; ethers such as diethyl ether, tetrahydrofuran, dioxane and dimethoxyethane; amides such as dimethylformamide, dimethylacetamide and hexamethylphosphoric triamide; sulfoxides, such as dimethyl sulfoxide; alcohols such as methanol, ethanol, propanol, isopropanol, butanol, isobutanol, and isoamyl alcohol; dilute acids, such as aqueous sulfuric acid; dilute bases such as aqueous sodium hydroxide; water; ketones such as acetone and methyl ethyl ketone; organic bases, such as pyridine, nitriles, such as acetonitrile; or a mixture of any two or more of the above solvents. Among them, halogenated hydrocarbons are preferable, and methylene chloride is particularly preferable.

The reaction is generally and can be carried out over a wide temperature range, and the precise reaction temperature is not particularly required for the present invention. The preferred reaction temperature is determined by the nature of the solvent, the starting materials or the reagents used, and the like. However, in general, the reaction is carried out at a temperature of-20 to 80 ℃, preferably-5 to 50 ℃. The reaction time can also vary within wide limits, depending on many factors, the main reaction temperature and the nature of the solvents and reagents used. However, assuming that the reaction is carried out under the above-mentioned preferred conditions, it is sufficient that the reaction is carried out for generally 1 to 24 hours, preferably 2 to 12 hours.

The optical resolving agent for carrying out optical resolution is not particularly limited, and examples thereof include tartaric acid, camphor-10-sulfonic acid and mandelic acid, and mandelic acid is particularly preferred.

The reaction is preferably carried out in a solvent. There is no particular limitation on the nature of the solvent used. Provided that it does not adversely affect the reaction or the reagents used and that at least some amount of the reactants may be dissolved. Examples of suitable solvents include: and (3) acetonitrile.

The resulting salt is resolved into the corresponding amine using an appropriate aqueous base such as aqueous sodium hydroxide, followed by extraction with a water-insoluble solvent (e.g., an aromatic hydrocarbon such as benzene, toluene, or xylene, a halogenated hydrocarbon such as dichloromethane or chloroform, or an ether such as diethyl ether), and isolation of the optically active sulfoxide derivative of formula (XXXIX). Step J5

In this step, the compound of formula (XXXIX) is prepared by removing the protecting group R¹⁴A compound of the formula (XXII) is prepared. This reaction can be carried out according to the method described in step C4 (i).

After completion of each of the above reactions, the desired compound can be isolated from the reaction mixture using conventional methods.

For example, in one suitable separation method, the reaction mixture is neutralized, if insoluble, filtered off and then a water-immiscible solvent (e.g., ethyl acetate) is added. The organic layer is separated, and then washed with, for example, water, and the resulting compound is dried using, for example, anhydrous magnesium sulfate or anhydrous sodium sulfate. The solvent was then distilled off to give the desired compound.

The resulting compound may, if desired, be purified by one or more of the following methods: recrystallizing and precipitating again; or other methods commonly used for separation and purification of organic compounds, for example, adsorption column chromatography using a carrier such as silica gel, alumina or magnesium-silica gel, Florisil; using a synthetic adsorbent, for example, partition column chromatography using Sephadex (trademark) LH-20 (manufactured by pharmacia Co., Ltd.), Amberlite (trademark) XAD-11 (manufactured by Rohm&Hass Co., Ltd.), Diaion (trademark) HP-20 (manufactured by Mitsubishi Kasei Co., Ltd.); using ion exchange chromatography; or normal/reverse phase liquid chromatography (preferably high performance liquid chromatography) using silica gel or alkylated silica gel.

The starting materials [ e.g., compounds of formula (XXXIV)]are commercially available or can be readily synthesized from known methods.

Biological activity

The novel compounds of the present invention have excellent antagonistic action against substance P and neurokinin A receptors, and further, due to their low toxicity, are useful for the prevention and treatment of diseases caused by the transfer of tachykinins, such as central nervous system diseases including anxiety, depression, psychosis and schizophrenia; neurodegenerative diseases including AIDS dementia, Alzheimer's senile dementia, Alzheimer's disease, Down's syndrome, demyelinating diseases, amyotrophic lateral sclerosis, neuropathy, peripheral neuropathy and neuralgia; respiratory diseases including chronic obstructive pulmonary disease, bronchitis, pneumonia, bronchoconstriction, asthma and cough; inflammatory diseases such as Inflammatory Bowel Disease (IBD), psoriasis, fibrosis, arthritis, osteoarthritis and rheumatoid arthritis; allergic diseases including eczema and rhinitis; allergic diseases, including allergy to vines; ophthalmic diseases including conjunctivitis, vernal mucositis, disruption of the aqueous blood barrier caused by various ocular inflammatory diseases, elevated intraocular pressure and miosis; skin diseases, including contact dermatitis, allergic dermatitis, urticaria and other eczematoid dermatitis; addiction, including alcohol addiction; physical illness caused by stress; sympathetic reflex type malnutrition, including hand and shoulder syndromes; dysthymia; undesirable immune responses, including transplant rejection; diseases associated with enhanced immunity including systemic lupus erythematosus or immunosuppression; digestive system diseases including diseases caused by abnormalities in the neuromodulatory apparatus, colitis, ulcerative colitis and Crohn'sdisease; emesis, including emesis caused by X-ray radiation and chemotherapy, poisons, toxins, pregnancy, vestibular disorders, post-operative disorders, gastrointestinal occlusion, gastrointestinal hypomotility, visceral pain disorders, migraine headaches, increased intracranial pressure, decreased intracranial pressure, or administration of various medications; disorders of bladder function including cystitis and urinary incontinence; eosinophilia caused by collagen disease, palpebral induration and Fasciola liver infection; diseases caused by abnormal blood flow due to vasodilation or vasoconstriction, including angina pectoris, migraine and Reynauds' disease; and nociceptive pain, including migraine, headache, and toothache.

The compounds of the invention may be formulated as oral preparations, for example as tablets, capsules, granules, powders and syrups, or as parenteral preparations, for example as injections or suppositories, these preparations being prepared in a manner known per se using additives such as excipients [ for example sugar derivatives such as lactose, sucrose, glucose, mannitol or sorbitol, starch derivatives such as corn starch, potato starch, α -starch, dextrin or carboxymethyl starch, cellulose derivatives such as crystalline cellulose, low-substituted hydroxypropylcellulose, hydroxypropylmethyl cellulose, carboxymethylcellulose calcium or internally crosslinked carboxymethylcellulose sodium, acacia, dextran, organic excipients such as pullulan, silicate derivatives such as light anhydrous silicic acid, synthetic aluminium or magnesium aluminates (maganesinuline metasiliciicalie), phosphates such as calcium phosphate, carbonates such as calcium carbonate, inorganic excipients such as sulfates (for example calcium sulfate), lubricants [ for example stearic acid and stearic acid metal salts, such as calcium stearate and magnesium stearate, talc, propolis, cetyl wax, and cetyl alcohol], or calcium phosphate, carbonates such ascalcium carbonate, inorganic excipients such as calcium carbonate, such as inorganic excipients such as sulfates (for example calcium sulfate), lubricants [ for example calcium sulfate, magnesium sulfate, sodium stearate, sodium lauryl sulfate, sodium stearate, sodium benzoate, sodium lauryl sulfate, sodium benzoate, sodium lauryl benzoate, sodium.

The dosage will vary depending on the severity of the disease, as well as the age and weight of the patient, and the route of administration. For example, when administered orally, the compound of the present invention is preferably administered once to several times daily at a dose of from 0.01mg/kg body weight (preferably 0.1mg/kg body weight, lower limit) to 100mg/kg body weight (preferably 50mg/kg body weight, upper limit), depending on the severity of the disease. When intravenous urea is administered, the dose is from 0.01mg/kg body weight (preferably 0.05mg/kg body weight, lower limit) to 100mg/kg body weight (preferably 50mg/kg body weight, upper limit) depending on the severity of the disease.

The biological activity of the compounds of the invention can be assessed by the following assay

NK₁Receptor binding assay (a) preparation of native Lung Membrane fraction

The natural lung membrane fraction was prepared from the lungs of male guinea pigs of the species Hartley. The guinea pigs were abdominally dissected under chloroform anesthesia and lung airway tissue was rapidly removed.

The extracted buffer (1) (50 mM) for lungpH7.4) pouring into a pot, and cutting. Then, the buffer (2) [ buffer (1) containing 120mM sodium chloride and 5mM potassium chloride]was treated with a Polytro homogen]And (4) stirring and homogenizing. Large pieces of tissue were filtered from the homogenate using a nylon sieve (50μm) and the supernatant was centrifuged (30,000Xg, 30 min, 4 ℃). The resulting pellets were resuspended in ice-cooled buffer (3) [ containing 10 mM%EDTA and 300mM potassium chloride buffer (1)]After standing at 4 ℃ for 60 minutes, the mixture was washed twice by centrifugation (30,000Xg, 15 minutes, 4 ℃).

The native lung membrane fraction was stored at-80 ℃ prior to use. (b) Receptor binding assays

The natural lung membrane fraction solution (250. mu.l) was added to the test drug and³H]substance P (final concentration: 1nM) (50 mM)pH 7.4; 6mM manganese dichloride, 800. mu.g/ml BSA, 8. mu.g/ml chymostatin, 8. mu.g/ml leupeptin, 80. mu.g/ml bacitracin, 20. mu.g/ml phosphoramidon), followed by incubation at room temperature for 30 minutes.

At the end of the culture, the lung membrane fraction was recovered using an automatic filter (manufactured by Brandel co.) equipped with a GF/B glass fiber filter (manufactured by Whatman co).

The glass filter was pretreated with 0.1% polyethyleneimine solution for about 4 hours before use to suppress nonspecific binding as little as possible. The filter from which the membrane components were recovered was transferred to a small plastic tube-shaped vial containing picoflow (4ml) and the radioactivity was measured using a liquid scintillation counter (LSC 3000, manufactured by Beckman co. The results are shown in Table 4

TABLE 4

Test compounds	IC50(ng/ml)
		Example 75 Compounds	5.9
Compound A	38
		Compound B	＞1000
Compound C	6.5

From the above results, it can be seen that the compounds of the present invention have antagonistic Nk₁The activity of the receptor, which is at least equal to the activity of the closest compound with the strongest activity in the prior art, compound C.

NK₂Receptor binding assay (a) preparation of native ileal membrane fraction

The native membrane fraction was prepared from the ileum of male guinea pigs of the species Hartley. The guinea pigs were abdominal incised under chloroform anesthesia and rapidly harvested to the ileum.

After scraping the contents, secretions and epithelium from the lumen using a glass slide, the ileum removed was buffered (1) (50 mM)pH7.4) and then in a buffer (2) [ buffer (1) containing 120mM sodium chloride and 5mM potassium chloride]And (4) homogenizing.

Large pieces of tissue were filtered from the homogenate using a nylon sieve (50 μm) and the supernatant was centrifuged (30,000Xg, 30 min, 4 ℃). The resulting pellet was resuspended in ice-cooled buffer (3) [ buffer (1) containing 10mM EDTA and 30mM potassium chloride], and left to stand at 4 ℃ for 60 minutes. Then washed twice by centrifugation (30,000Xg, 15 min, 4 ℃).

The natural membrane fraction was stored at-80 ℃ before use. (b) Receptor binding assays

The natural membrane portion solution (250. mu.l) was added to the test drug and [2]³H]SR-48968 (manufactured by Amasham Co., final concentration: 1nM) (50 mM)pH7.4; 4.6mM manganese dichloride, 800. mu.g/ml BSA, 8. mu.g/ml chymostatin, 8. mu.g/ml leupeptin, 80. mu.g/ml bacitracin, 20. mu.g/ml phosphoramidon), followed by incubation at room temperature for 30 minutes.

At the end of the culture, membrane fractions were recovered using an automatic transition apparatus (manufactured by Brandel Co.) equipped with GF/B glass fiber filters (manufactured by Whatman Co.). The glass filter was pretreated with 0.1% polyethyleneimine solution for about 4 hours before use to minimize inhibition of non-specific binding. The filter from which the membrane component was recovered was transferred to a small plastic tube-shaped bottle containing pico flow (4ml) and the radioactivity was measured using a liquid scintillation counter (LSC 3000, manufactured by beckmanco).

Comparison of the Compounds of the present invention to the NK₁And NK₂The receptor showed goodActivity of (2).

The results are shown in Table 5

TABLE 5

Test compounds	IC50(ng/ml)
		Example 75 Compounds	0.85
Compound A	18
		Compound B	2.2
Compound C	31

As can be seen from the above results, NK antagonism to the compounds of the present invention₂The activity of the receptor, which is greater than any of the closest compounds in the prior art. In addition, NK₁The most active compound C was bound in this assay, which was very weak.

Inhibition of SP-induced elevated vascular permeability

Guinea pig (volume: about 400g, male Hartley guinea pig) was used as the test animal, and leakage of pigment was used as the test animalIndex evaluation pair consisting of Substance P (SP), an NK₁Inhibition of the increase in vascular permeability induced by receptor agonists. SP (1mg/kg, i.v.) was used immediately after addition of pigment (Evans blue: 20mg/kg, i.v.) and test drug to the guinea pig femoral vein under pentobarbital anesthesia (25mg/kg, i.p.) to induce an increase in vascular permeability. Fifteen minutes later, the guinea pigs were sacrificed under chloroform anesthesia and the amount of pigment permeating into the main bronchi was measured according to the method of Harada (j.pharm. pharmacol., 23, 218, 1971). Inhibition was measured in terms of the amount of pigment penetration found in guinea pigs not treated with the test drug and is expressed in terms of percent inhibition (%) and the dose (ID50) that resulted in 50% inhibition.

The results are shown in Table 6

TABLE 6

Test compounds	ID(mg/kg.iv)
		Example 75 Compounds	0.025
Example 77 Compounds	0.047
		Compound A	5.8
Compound B	＞10
		Compound C	0.019

From the above results, it can be seen that the compounds of the invention have an inhibitory effect on the increase in vascular permeability induced by substance p, with an action strength at least equal to that of the closest compound of the prior art, compound C, which is the most active.

Inhibition of NKA-induced bronchiectasis

Guinea pigs (body weight: about 500g, male Hartley guinea pigs were used as test animals according to the modified method of Konzett-Rossler [ Nauyn-Schmiedeebergs Arch.Exp.Pathol.Pharmakol.195, 71, (1940)]Using airway pressure as index to specify the general formula [ Nle¹⁰]-NKA (4-10), an NK specific for neurokinin A (NKA) higher₂Receptor agonists, inhibition of induced bronchodilation.

Pentobarbital anesthesia (30mg/kg, s.c.) followed by tracheal intubation in guinea pigs and treatment with Carlamine (20mg/kg, i.v.), at a frequency of 60 per minute and a tide of 8ml/kgVolume, experimental animals were artificially ventilated with a constant volume respiratory pump (Ugo Basile, 7025). Airway pressure during artificial ventilation was amplified by a pressure transducer (Nihon Koden. tp-200T) mounted on the endotracheal tube branch, measured (Nihon Koden, AP-610G), and recorded with a recorder (Nihon Koden, WT-685G). Test drugs were injected intravenously after pretreatment with atropine (1mg/kg, i.v.) and propranolol (1 mg/kg.i.v.). Five minutes later, [ Nle]at 4mg/kg.i.v¹⁰]-NKA[4-10]Bronchodilation was induced and airway pressure was then measured over a period of 10 minutes. The inhibition was determined from the intensity of bronchodilation in guinea pigs not treated with test drug, and the percent inhibition (%) and the dose (ID) resulting in 50% inhibition were used₅₀) To indicate.

The results are shown in Table 7:

TABLE 7

Test compounds	ID50(mg/kg.iv.)
		Example 75 Compounds	0.074
Example 77 Compounds	0.047
		Compound A	＞10
Compound B	0.37
		Compound C	1.7

As can be seen from the above results, the compounds of the present invention have antagonistic NK activity₂The activity of the receptor, which is greater than any of the closest compounds in the prior art.

As can be seen from the above data, the compounds of the present invention are directed to NK₁And NK₂All receptors have strong antagonismAnd (4) resisting activity. In addition, the compounds of the present invention are useful for NK₁Antagonistic activity against receptors at least equal to that of the closest compounds of the prior art, and against NK₂The antagonistic activity of the receptor is greater than that of the closest compounds in the prior art.

Preparation example 1

N, N-dimethyl-1-tert-butyloxycarbonyl-4-phenylpiperidine-4-carboxamide

1.0g (3.27mmole) of tert-butoxycarbonyl-4-phenylpiperidine-4-carboxylic acid are dissolved in 20ml of anhydrous dichloromethane, and 690mg (3.6mmole) of 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride, 490mg (3.6mmol) of 1-hydroxybenzotriazole, 1.3ml (7.53mmole) of diisopropylethylamine and 295mg (3.93mmole) of diethylamine hydrochloride are added to the resulting solution, which is then stirred at room temperature under a nitrogen atmosphere for 15 hours. At the end of the stirring, the reaction mixture was diluted with dichloromethane, washed sequentially with water and saturated solution of sodium chloride, and then dried over anhydrous sodium sulfate.

The solvent was removed by distillation under the reduced pressure, and the residue was purified by silica gel column chromatography using a gradient elution method with a mixture of ethyl acetate and hexane in a volume of 10: 1 to 7: 1 as an eluent, to give 925mg (yield 85%) of the title compound as white crystals. Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃) δ ppm: (the following and following preparations and examples have the following meanings in English words in nuclear magnetic data: double triplets for double doublets, multiplets for multiplets, broad singlets for broad Singlet, doublets for doublets, singlets for Singlet, triplets for doublets, doublets for doublets, and the like.

7.34(2H，doublet of triplets，J＝6.7&1.9Hz)；

7.26-7.21(3H，multiplet)；

3.96(2H，broad singlet)；

3.21(2H，broad singlet)；

2.85(3H，broad singlet)；

2.60(3H，broad singlet)；

2.31(2H，doublet，J＝12.05Hz)；

1.87(2H，broad singlet)；

1.45(9H, singlets). Mass Spectrometry (EI) m/z: 332 (M)⁺). "EI" means "electron impact ionization"

Preparation example 2

N, N-dimethyl-4-phenylpiperidine-4-carboxamide hydrochloride

900mg (2.7mmole) of N, N-dimethyl-1-tert-butoxycarbonyl-4-phenylpiperidine-4-carboxamide (prepared as described in preparation example 1) are dissolved in 10ml of ethyl acetate under ice cooling, and 5ml of a 4N hydrogen chloride solution in dioxane are added thereto. The mixture was then stirred at 0 ℃ for 1 hour. At the end of the stirring, the precipitated crystals were collected by filtration to yield 690mg (yield 95%) of the title compound as white crystals. Nuclear magnetic resonance spectrum (400MHz, hexadeuterium dimethyl sulfoxide (δ ppm):

9.02(1H，broad singlet)；

7.43(2H，triplet，J＝7.6Hz)；

7.31(1H，doublet，J＝7.2Hz)；

7.23(2H，doublet，J＝7.1Hz)；

3.25(2H，doublet，J＝13.1Hz)；

3.03(2H，triplet，J＝12.1Hz)；

2.79(3H，broad singlet)；

2.54(3H，broad singlet)；

2.37(2H，doublet，J＝12.9Hz)；

2.11(2H，doublet of triplets，

J＝13.4&3.3Hz) mass spectrometry (EI) m/z: 232 (free form, M)⁺)

Preparation example 3

Spiro (benzo [ C]thiophene-1 (3H), 4' -piperidine]hydrochloride

3(a)1 '-Cyanospiro [ benzo [ C]thiophene-1 (3H), 4' -piperidine]

2.34g (22.1mmol) of cyanogen bromide are dissolved in 20ml of anhydrous chloroform and 2.2g (10mmole) of an anhydrous chloroform solution of 1 '-methylspiro [ benzo [ c]thiophene-3 (H), 4'-piperidine][ synthesized as described in J.org.chem., Vol.41.page 2628(1976)]are added dropwise over a period of 20 minutes under nitrogen atmosphere under reflux. The mixture was then heated under reflux for 9 hours, after which the reaction mixture was cooled and poured into ice-cooled 1N aqueous hydrochloric acid solution. The chloroform layer was separated, washed with water and dried over anhydrous sodium sulfate.

The solvent was evaporated under reduced pressure and the residue was purified by column chromatography on silica gel using a 1: 9 by volume mixture of ethyl acetate and hexane as eluent to give 1.3g (56% yield) of the title compound as white crystals. Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.38-7.27(3H，multiplet)；

7.21(1H，doublet of doublets，

J＝1.9&6.4Hz)；

4.20(2H，singlet)；

3.51(2H，multiplet)；

3.37(2H，doublet，of triplets

J＝2.2&12.9Hz)；

2.29(2H，doublet of triplets，

J＝4.6&12.9Hz)；

1.91(2H, multiplex). Mass Spectrometry (FAB) m/z: 231(M + M)⁺) FAB is "fast atom bombardment" 3(b) 1' -tert-butyloxycarbonyl spiro [ benzo [ C]]Thiophene-1 (3H), 4' -piperidines]1.3g (5.64mmole) of 1' -cyanospiro [ benzo [ C]]Thiophene-1 (3H),4' -piperidines][ preparation according to the above step (a)]Dissolved in 20% w/v aqueous hydrochloric acid and the solution heated to reflux for 20 hours. At the end of the heating, the reaction mixture was cooled and washed with ethyl acetate. The aqueous layer was separated and basified with 10% w/v aqueous sodium hydroxide; it was then extracted three times with chloroform. The solvent of the combined extracts was removed by distillation under reduced pressure, and the residue was dissolved in anhydrous dichloromethane; under ice-cooling, 1.15ml (8.18mmol) of triethylamine and 1.45g (6.64mmol) of di-tert-butylcarbonate were added. The mixture was then stirred at room temperature for 2 hours. At the end of the stirring, the reaction mixture was diluted with dichloromethane and washed sequentially with water and saturated aqueous sodium chloride solution. The organic layer was separated and dried over anhydrous sodium sulfate, and then the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography using ethyl acetate and hexane in a volume ratio of 3: 97 as an eluent to give 1.65g (yield 96%) of the title compound as white crystals. Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.28-7.24(3H，multiplet)；

7.17-7.15(1H，multiplet)；

4.23(2H，broad singlet)；

4.19(2H，singlet)；

3.02(2H，broad singlet)；

2.07(2H，doublet，of triplets

J＝4.4&13Hz)；

1.88(2H，multiplet)；

1.49(9H, singlet). Mass Spectrometry (EI) m/z: 305 (M)⁺)

3(C) spiro [ benzo [ C]]Thiophene-1 (3H), 4¹-piperidine (III)]Hydrochloride salt

150mg (0.49mmole) of 1 '-tert-butoxycarbonylspiro [ benzo [ C]thiophene 1(3H), 4' -piperidine][ prepared as in step (b) above]was dissolved in 3ml of anhydrous dichloromethane, and 1ml of 4N dioxane hydrochloride solution was added. The mixture was then stirred at room temperature for 1 hour. At the end of the stirring, the crystals deposited were collected by filtration to yield 108mg (yield 91%) of the title compound as white crystals. Nuclear magnetic resonance spectrum (400MHz, hexadeuterium dimethyl sulfoxide) δ ppm:

9.77(2H，broad singlet)；

7.37-7.25(4H，multiplet)；

4.24(2H，singlet)；

3.67(2H，doublet，J＝12.6Hz)；

3.26(2H，doublet of triplets，

J＝12.6&2.5Hz)；

2.74(2H，doublet of triplets，

J＝3.8&14.0Hz)；

2.09(2H, doublet, J ═ 14.0 Hz). Mass Spectrometry (FAB) m/z: 206(M + H)⁺(free form)

Preparation example 4

Spiro [ benzo [ C]thiophene-1 (3H), 4' -piperidine]-2-oxide hydrochloride

4(a)1 '-tert-Butoxycarbonylspiro [ benzo [ C]thiophene-1 (3H), 4'

-piperidine]-2-oxide

485mg (1.59mmole) of 1' -tert-butoxycarbonylspiro [ benzo [ C]was added under ice-cooling]Thiophene-1 (3H), 4' -piperidines][ preparation according to the above preparation example 3(b)]]Dissolved in 5ml of anhydrous dichloromethane, 148mg (1.76mmole) of sodium hydrogencarbonate and subsequently 325mg (1.88mmole, content: 85%) of m-chloroperbenzoic acid were added. The reaction mixture was stirred for 30 minutes under ice-cooling, after which it was diluted with dichloromethane and washed sequentially with water and a saturated aqueous solution of sodium chloride. The solution was dried over anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure. The resulting residue was purified by thin layer chromatography using ethyl acetate and hexane in a 2: 1volume ratio as developing solvent to give 498mg (98% yield) of the title compound as white crystals. Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.37-7.32(3H，multiplet)；

7.25-7.23(1H，multiplet)；

4.37(1H，doublet，J＝16.7Hz)；

4.13(2H，broad singlet)；

4.05(2H，doublet，J＝16.7Hz)；

3.21(2H，broad singlet)；

2.43(1H，multiplet)；

2.21(1H，multiplet)；

1.70(1H，multiplet)；

1.61(1H，multiplet)；

1.50(9H, single); mass Spectrometry (FAB) m/z: 322(M + H)⁺

4(b) spiro [ benzo [ C]thiophene-1 (3H), 4' -piperidine]-2-

Hydrochloride of an oxide

295mg (0.92mmol) of 1 '-tert-butoxycarbonylspiro [ benzo [ C]]thiophene 1(3H), 4' -piperidine]-2-oxide (prepared as in the above step (a)) was dissolved in 3ml of dichloromethane, and 1ml of 4N hydrogen chloride dioxane solution was added under ice-cooling, the mixture was stirred for 1 hour, and then the deposited crystals were collected by filtration to give 173mg (yield 75%) of the title compound as white crystals under ice-cooling, nuclear magnetic resonance spectroscopy (400MHz, deuterium dimethyl sulfoxide) δ ppm:

9.13(2H，broad singlet)；

7.44-7.36(3H，multiplet)；

7.33-7.31(1H，multiplet)；

4.66(1H，doublet，J＝17Hz)；

4.08(1H，doublet，J＝17Hz)；

3.49-3.37(2H，multiplet)；

3.15-3.00(2H，multiplet)；

2.66-2.57(1H，multiplet)；

2.27-2.23(1H，multiplet)；

2.18-2.10(1H，multiplet)；

1.97-1.93(1H, multiplex); mass Spectrometry (FAB) m/z: 222(M + H)⁺(free form)

Preparation example 5

Spiro [ benzo [ C]thiophene-1 (3H), 4' -piperidine]-2, 2-dioxide hydrochloride

5(a) 1' -tert-butoxycarbonylspiro [ benzo [ C]thiophene-1 (3H),

4' -piperidine]-2, 2-dioxide

190mg (0.59mmole) of 1' -tert-butoxycarbonylspiro [ benzo [ C]]Thiophene 1(3H), 4' -piperidines]-2-oxide [ prepared as in preparation 4(a) above]Dissolved in 30ml of methanol, and then dissolved in the solvent,and 10ml of an aqueous solution containing 270mg (1.77mmole) of Oxone (trade mark) were added. The reaction mixture was stirred at room temperature for 5 days, after which it was poured into water and extracted twice with chloroform. The organic extract was separated, dried over anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure. The resulting residue was purified by thin layer chromatography using a 1: 1 volume ratio mixture of ethyl acetate and hexane as a developing solvent to give 175mg (88% yield) of the title compound as white crystals. Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.52-7.27(3H，multiplet)；

7.23-7.20(1H，multiplet)；

4.36(2H，singlet)；

4.10(2H，broad singlet)；

3.44(2H，broad singlet)；

2.38(2H，multiplet)；

2.00(2H，multiplet)；

1.50(9H, singlets). Mass Spectrometry (FAB) m/z: 337 (M)⁺)

5(b) spiro [ benzo [ C]thiophene-1 (3H), 4' -piperidine]-2, 2-

Dioxide hydrochloride

170mg (0.5mmole) of 1 '-tert-butoxycarbonylspiro [ benzo [ C]thiophene-1 (3H), 4' -piperidine]-2, 2-dioxide [ prepared as in step (a) above]was dissolved in 3ml of dichloromethane under ice-cooling, and 1ml of 4N hydrogen chloride dioxane solution was added. The mixture was then stirred under ice-cooling for 1 hour, after which the deposited crystals were collected by filtration to give 131mg (yield 95%) of the title compound as white crystals. Nuclear magnetic resonance spectrum (400MHz, hexadeuterium dimethyl sulfoxide) δ ppm:

9.32(2H，broad singlet).

7.51-7.35(4H，multiplet).

4.74(2H，singlet).

3.45-3.67(2H，multiplet).

3.24-3.12(2H，multiplet).

2.47-2.43(4H, multiplex). Mass Spectrometry (FAB) m/z: 238(M + H)⁺(Game)From type)

Preparation example 6

Spiro [ benzo [ C]thiophene-1 (3H), 4' -piperidine]- (2S) -oxidations

Substance hydrochloride

6(a) Spiro 1 '-Boc-Spiro [ benzo [ C]thiophene-1 (3H), 4' -piperidine]

81.0g (0.40mole) of 2-bromobenzylthiol are dissolved in 800ml of tetrahydrofuran and 0.84mole of butyllithium (solution in 1.6M hexane) is added dropwise at a temperature of-78 ℃ over a period of 6 hours. Then, the mixture was stirred at this temperature for 1.5 hours, after which 800ml of a tetrahydrofuran solution containing 79.5g (0.40mole) of 1-t-butoxycarbonyl-4-piperidone was added dropwise over a period of 3 hours. The solution was stirred for another 1 hour, and then a saturated aqueous solution of ammonium chloride was added. And the mixture was extracted with ethyl acetate. The organic extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. To the residue was added 2 liters of a 4N aqueous sulfuric acid solution, and the mixture was heated under reflux for 14 hours. At the end of heating, 350g (8.75mole) of sodium hydroxide was added under ice cooling to basify the solution, and then 102g (0.47mole) of di-t-butyl carbonate (di-t-butyl carbonate) was added.The mixture was stirred for 1 hour. At the end of the stirring, it is extracted with dichloromethane and the organic extract is washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by column chromatography on silica gel using a 97: 3 volume ratio mixture of hexane and ethyl acetate as eluent to give 56g of the title compound as white crystals with a melting point of 131.0-132.5 deg.C (after crystallization from hexane/ethyl acetate). Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.28-7.24(3H，multiplet)；

7.17-7.15(1H，multiplet)；

4.23(2H，broad singlet)；

4.19(2H，singlet)；

3.02(2H，broad singlet)；

2.07(2H，doublet of triplets，

J＝4.4&13Hz)；

1.88(2H，multiplet)；

1.49(9H, singlets.) Infrared absorption Spectrum v_maxcm^-1(KBr): 2970, 1680, 1428, 1234, 1163. Mass Spectrometry (FAB) m/z: 306(M + H)⁺

6(b) 1' -Boc-Spiro [ benzo [ C]thiophene-1 (3H)

4' -piperidine]-2-oxide

42.0g (0.14mole) of 1' -tert-butoxycarbonylspiro [ benzo [ C]]Thiophene-1 (3H), 4' -piperidines][ preparation according to the above step (a)]Dissolved in 420ml chloroform and added with 12.7g (0.15mole) sodium bicarbonate. Under ice-cooling, 28.0g (0.14mole) of m-chloroperbenzoic acid (purity 95%) was added little by little. Then, the mixture was stirred for 30 minutes under ice-cooling, after which 10g of potassium iodide was added, and the mixture was stirred for another 30 minutes at room temperature. The reaction mixture was washed with water and then saturated aqueous solution of sodium chloride, and anhydrous magnesium sulfateAnd (5) drying. Thereafter, the solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography using a 1: 1 volume ratio mixture of hexane and ethyl acetate as an eluent to give 42g of the title compound as white crystals having a melting point of 103 ℃ and 107 ℃ (crystallization from diisopropyl ether). Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.37-7.32(3H，multiplet)；

7.25-7.23(1H，multiplet)；

4.37(1H，doublet，J＝16.7Hz)；

4.13(2H，broab singlet)；

4.05(2H，doublet，J＝16.7Hz)；

3.21(2H，broad singlet)；

2.43(1H，multiplet)；

2.21(1H，multiplet)；

1.70(1H，multiplet)；

1.61(1H，multiplet)；

1.50(9H, singlets.) Infrared absorption Spectrum v_maxcm^-1(KBr): 2985, 1686, 1429, 1368, 1286, 1167. Mass spectrometric analysis(FAB)m/z：322(M＋H)⁺

6(C) spiro [ benzo [ C]thiophene-1 (3H), 4' -piperidine]-2-oxide

42.0g (0.13mole) of 1 '-tert-butoxycarbonylspiro [ benzo [ C]thiophene-1 (3H), 4' -piperidine]-2-oxide [ prepared as in step (b) above]was dissolved in 420ml of 2-propanol under ice-cooling, and 150ml of a 4N hydrogen chloride dioxane solution was added. The mixture was then stirred for 4 hours. At the end of the stirring, 200ml of ether was added to the mixture under ice-cooling, and it was left for l hours. The precipitated crystals were collected by filtration. The crystals were dissolved in 200ml of 5% w/v aqueous sodium hydroxide solution. The resulting product was extracted with dichloromethane and the organic extracts were dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain 21.7g of the title compound in the form of a white amorphous.

6(d) Spiro [ benzo [ C]thiophene-1 (3H), 4' -piperidine]- (2S)

(S) - (+) -mandelate salt as monoxide

33.51g (0.15mole) of spiro [ benzo [ C]thiophene-1 (3H), 4' -piperidine]-2-oxide [ prepared as described in step (C) above]were dissolved in 3350ml of acetonitrile with heating. 11.52g (75.7mmole) (S) - (+) -mandelic acid was then dissolved in the solution obtained. The mixture was allowed to stand at room temperature overnight, and the precipitated crystals were collected by filtration to give 19.62g of the title compound as white crystals. The mother liquor was concentrated by evaporation under reduced pressure and the residue obtained was dissolved in 5% w/v aqueous sodium hydroxide solution; it was then extracted with dichloromethane. The organic extract was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain 22.01g (99.5mmole) of a residue. The residue was dissolved in 2200ml of acetonitrile by heating, and then 7.22g (47.5mmole) (R) - (-) -mandelic acid was dissolved therein. The mixture was allowed to stand at room temperature overnight, and the precipitated crystals were collected by filtration to give 15.91g of spiro [ benzo [ C]thiophene-1 (3H), 4' -piperidine]- (2R) -oxide (R) - (-) -mandelate as white crystals. The mother liquor was concentrated by evaporation under reduced pressure, and the resulting residue was dissolved in 5% w/v aqueous sodium hydroxide solution and extracted with dichloromethane. The organic extract was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain 11.51g (52.0mmole) of a residue. The residue was dissolved in 1100ml of acetonitrile by heating, and 3.95g (26.0mmole) (S) - (+) -mandelic acid was dissolved therein. The mixture was left at room temperature overnight. The precipitated crystals were collected by filtration to obtain 4.73g of the title compound as white crystals.

All the resulting title compounds were combined, heated to redissolve 24.00g of the compound in 9.6 liters of acetonitrile, and the solution was allowed to stand overnight at room temperature. 20.13g of precipitated crystals were obtained, having a melting point of 197-. Converting it into a 1' -tert-butoxycarbonylspiro [ benzo [ C]]Thiophene-1 (3H), 4' -piperidines]- (2S) -oxide, HPLC (high Performance liquid chromatography) analysis showed 99.8% ee in optical purity [ α]]_D ²⁴+ 78.3 (C1, methanol) infrared absorption spectrum v_maxcm^-1(KBr): 3388, 3029, 1629, 1332, 1017. Mass Spectrometry (EI) m/z: 221(free form, M)⁺)

6- (e) 1' -tert-butoxyspiro [ benzo [ C]thiophene-1 (3H),

4' -piperidine]- (2S) -oxide

19.88g (53.2mmole) of spiro [ benzo (C)]Thiophene-1 (3H) 4' -piperidines]- (2S) -oxide (S) - (+) -mandelate salt prepared according to step (d) above]Dissolving in 200ml of 5% w/v aqueous sodium hydroxide solution and extracting three times with 200ml of dichloromethane each time, drying the combined organic extracts over anhydrous magnesium sulfate, then evaporating off the solvent under reduced pressure, dissolving 11.80g of the residue in 300ml of dichloromethane under ice cooling, and adding 11.2ml (79.8mmole) of triethylamine and 17.4g (79.8mmole) of di-tert-butyl carbonate in succession, stirring the mixture at room temperature overnight, at the end of the stirring, diluting the reaction mixture with 200ml of dichloromethane, washing it with 10% w/v aqueous citric acid and then with saturated aqueous sodium bicarbonate, drying it over anhydrous magnesium sulfate, evaporating off the solvent under reduced pressure, eluting with a mixture of hexane and ethyl acetate in a volume ratio of 4: 6 to 3: 7, purifying the residue by column chromatography using gradient elution, then recrystallizing it with diisopropyl ether to give 13.1g of the title compound in the form of white crystals, m.p. 129.0-130.5 ℃ [ α]]_D ²⁴+ 57.1(C ═ 1, methanol) HPLC analysis

Column: chiral Cel OD (250X 4.6mm phi)

Eluent: hexane: 2-propanol 80: 20 by volume

Flow rate: 0.8 ml/min

Retention time: 18.1 minutes

The NMR spectrum, IR absorption spectrum and mass spectrum analysis data of this isomer were in agreement with those of the racemate described in preparation example6 (b).

6(f) Spiro [ benzo [ C]thiophene-1 (3H), 4' -piperidine]-2(S)

-oxide hydrochloride

Under ice-cooling, 13.0g (40.4mmole) of 1' -tert-butoxycarbonylspiro [ benzo [ C]]Thiophene-1 (3H), 4' -piperidines]- (2S) -oxide [ prepared as in step (e) above]Dissolved in 130ml of 2-propanol and 50ml of 4N hydrogen chloride in dioxane were added. The mixture was stirred at the same temperature for 1 hour, and then at room temperature for another 6 hours. The reaction mixture was concentrated by evaporation under reduced pressure. 200ml of diethyl ether are added to the residue and the solvent is distilled off under reduced pressure;this procedure was repeated three times and the residue was recrystallized from 300ml of a 1: 2 by volume mixture of methanol and diethyl ether to give 9.10g of the title compound as white crystals having a melting point of 209.5-210.5 ℃ [ α]]_D ²⁴+63.8(C ═ 1, methanol) nuclear magnetic resonance spectrum (400MHz, CD)₃OD)δppm：

7.38-7.46(4H，multiplet)；

4.69(1H，doublet，J＝17.2Hz)；

4.17(1H，doublet，J＝17.2Hz)；

3.52-3.63(2H，multiplet)；

3.25-3.40(2H，multiplet)；

2.62(1H，multiplet)；

2.51(1H，multiplet)；

2.22(1H，multiplet)；

2.06(1H，multiplet).

6(g) 1' -tert-butoxycarbonylspiro [ benzo [ C]thiophene-1 (3H).

4' -piperidine]-2(S) -oxide

250mg (0.82mmole) of 1 ' -tert-butoxycarbonylspiro [ benziso [ C]thiophene-1 (3H), 4 ' -piperidine]was dissolved in 5ml of methylene chloride, and 308mg (0.82mmole) of (3 ' S, 2R) - (-) -N- (benzenesulfonyl) (3, 3-dichlorocamphoryl) oxaziridine synthesized by the procedure of F.A.Davis et al [ J.Am.chem.Soc., 114.1428(1992)]was added to the resulting solution. The resulting mixture was then stirred at room temperature overnight. 500mg of potassium iodide was added to the mixture, and the mixture was stirred for 30 minutes. Then, it was washed with water and a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography using a 1: 2 volume ratio mixture of hexane and ethyl acetate as an eluent to give 245mg of the title compound.

Optical purity: 94% ee

Preparation example 7

3- (3, 4-dichlorophenyl) -3-butenol tert-butyl dimethyl

Silyl ethers

7(a)3- (3, 4-dichlorophenyl) -3-oxo-1-propanol

L19g (0.46mole) ethyl 3- (3, 4-dichlorophenyl) -3-oxopropanoate was dissolved in 2.4 l ethanol and 115ml (0.68mole) ethyl orthoformate and 4.4g (22.8mmole) p-toluenesulphonic acid were added. The mixture was heated to reflux for 8 hours. At the end of the reflux, the reaction solution was poured into 1 l of saturated aqueous sodium bicarbonate solution and extracted three times with 700ml of ethyl acetate each time. The combined organic extracts were washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was dissolved in 800ml of tetrahydrofuran, and then 4 liters of a tetrahydrofuran suspension containing 25.9g (0.68mole) of lithium aluminum hydride was added dropwise thereto under ice-cooling over a period of 1 hour. The mixture was stirred at 0 ℃ for 2 hours, then 250ml of water and 125ml of 10% w/sodium hydroxide aqueous solution were added and the mixture was stirred at room temperature for a further 1 hour. It was filtered through a Celite (trade name) filter, and the filtrate was poured into 1L of a saturated aqueous solution of sodium chloride and extracted with ethyl acetate. The organic extracts were dried over anhydrous sodium sulfate and concentrated by evaporation under reduced pressure. The residue obtained is dissolved in 500ml of chloroform. 500ml of 50% v/v trifluoro were added over a period of 30 minutes under ice coolingAn aqueous acetic acid solution was added to the resulting solution. And the mixture was stirred at the same temperature for another 30 minutes. At the end of the stirring, the reaction solution was diluted with 300ml of chloroform, and the organic layer was washed with water and then with an aqueous solution of sodium hydrogencarbonate, followed by drying over anhydrous sodium sulfate. The solvent was removed under reduced pressure and the resulting residue was purified by column chromatography on silica gel using a 9: 1 by volume mixture of hexane and ethyl acetate as eluent to give 46g of the title compound as white crystals. Nuclear magnetic resonance spectroscopy (270MHz, CDCl)₃)δppm：

8.05(1H，doublet，J＝2.0Hz)；

7.79(1H，doublet of doublets，

J＝2.0&8.1Hz)；

7.57(1H，doublet，J＝8.1Hz)；

4.04(2H，multiplet)；

3.19(2H，triplet，J＝5.3Hz)；

2.44(1H, triplet, J ═ 6.6Hz), this peak was spiked with D₂ODisappear when necessary)

7(b)3- (3, 4-dichlorophenyl) -3-oxo-1-propanol

Tert-butyldimethylsilyl ether

46.0g (0.21mole) of 3- (3, 4-dichlorophenyl) -3-oxo-1-propanol [ prepared according to step (a) above]Dissolved in 460ml of methylformamide and added with 35ml (0.25mole) of triethylamine and 38.0g (0.25mole) of tert-butyldimethylsilyl chloride. The mixture was then stirred at 0 ℃ for 2 hours. At the end of stirring, the reaction mixture was poured into water and extracted with ethyl acetate. The organic extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography using hexane and ethyl acetate in a 96: 4 volume ratio as an eluent to give 66.1g of the title compound as white crystals. Nuclear magnetic resonance spectroscopy (270MHz, CDCl)₃)δppm：

8.06(1H，doublet，J＝2.0Hz)；

7.80(1H，doublet of doublets，

J＝2.0&8.3Hz)；

7.55(1H，doublet，J＝8.3Hz)；

4.04(2H，triplet，J＝6.3Hz)；

3.13(2H，triplet，J＝6.3Hz)；

0.85(9H，singlet)；

0.04(6H，singlet).

7(C)3- (3, 4-dichlorophenyl) -3-butenol tert-butyl bis

Methyl silyl ethers

215g (0.60mole) of methyltriphenyl bromide and 54g (0.48mole) of potassium tert-butoxide were added to 2 liters of anhydrous benzene, and the mixture was stirred at room temperature for 9 hours. At the end of the stirring, a solution of 40g (0.12mole) of 3- (3, 4-dichlorophenyl) -3-oxo-1-propanol tert-butyldimethylsilyl ether [ prepared according to the above step (b)]dissolved in 800ml of benzene was slowly dropped into the mixture over a period of 2.5 hours. Then, 1 liter of water was added to the reaction mixture, and the reaction mixture was stirred for 30 minutes under ice-cooling. The organic phase was separated, washed with water and saturated aqueous solution of sodium chloride, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the resulting residue was purified by silica gel column chromatography using hexane as an eluent to give 23.5g of the title compound. The physicochemical properties of this product were the same as the product prepared in example 1 (b).

Preparation example 8

3- (3, 4-dichlorophenyl) -3-butenol tert-butyl dimethyl

Silyl ethers

129mg (5.31mmole) of magnesium flakes are added to 2ml of diethyl ether and a small amount of iodine is added to the mixture. A solution of 1.01g (4.47 mmoles) of 3, 4-dichlorobromobenzene in 1ml of diethyl ether was then added dropwise to the mixture, and the mixture was stirred at room temperature for 1 hour under a nitrogen atmosphere to give the Grignard reagent.

500mg (1.60mmole) of 3-iodo-3-butanol tert-butyldimethylsilyl ether and 34mg (0.048mmole) of dichlorobis (triphenylphosphine) palladium (II) were dissolved in 5ml of tetrahydrofuran and the Grignard reagent previously prepared was added dropwise at room temperature under nitrogen. As the reaction temperature rose, diethyl ether was distilled off and the reaction mixture was heated at 60 ℃ for 1 hour. At the end of the heating, the reaction mixture was poured into aqueous ammonium chloride solution and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatographyusing hexane as an eluent to give 422mg of the title compound. The physicochemical properties of this product are identical to those of the product of example 1 (b).

Example 11- {2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4-phenylpiperidine-4-carboxamide 1(a) methyl 3- (3, 4-dichlorophenyl) -3-butanoate

To 300ml of diethyl ether was added 11.31g (0.47mole) of magnesium flakes followed by a small amount of iodine. The mixture was then left to stand for 1 hour, after which a solution of 102.87g (0.46mole) of 1-bromo-3, 4-dichlorobenzene in 150ml of diethyl ether was slowly added dropwise. 150ml of diethyl ether are additionally added, then 60.33g (44.3mmole) of anhydrous zinc chloride are slowly added and the mixture is stirred for 1 hour. Then 3.10g (4.42mmole) are addedDichlorobis (triphenylphosphine) palladium (II) and a solution of 34.15ml (42.8mmole) of diketene in 600ml of diethyl ether is added dropwise. The reaction mixture is stirred at room temperature for 30 minutes, then poured into 1 l of ice-cooled 1N aqueous hydrochloric acid and extracted three times with 500ml of diethyl ether each time. The combined organic extracts were extracted three times with 700ml of 1N aqueous sodium hydroxide solution each time. The combined aqueous extracts were acidified with concentrated aqueous hydrochloric acid and extracted three times with 500ml of ether each time under ice cooling, and the combined organic extracts were dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was dissolved in 350ml of methanol. 10ml of concentrated sulfuric acid aqueous solution was added, and the solution was heated under reflux for 30 minutes. At the end of the reflux, the reaction mixture was cooled in air and neutralized with a saturated aqueous solution of sodium bicarbonate. Methanol was distilled off under reduced pressure and the residue was extracted three times with 200ml of dichloromethane each time. The combined organic extracts were dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure. The resulting residue was distilled under reduced pressure to give 69.13g (yield 62%) of the title compound as a pale yellow oil having a boiling point of 144 ℃ and 146 ℃ (5 mmHg). CoreMagnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.51(1H，doublet，J＝2.2Hz)；

7.40(1H，doublet，J＝8.2Hz)；

7.25(1H，doublet，of doublets，

J＝8.2&2.2Hz)；

5.55(1H，singlet)；

5.30(1H，singlet)；

3.67(3H，singlet)；

3.49(2H, singlet). 1(b)3- (3, 4-dichlorophenyl) -3-butenol tert-butyldimethylsilyl ether

11.76g (0.28mole) of lithium aluminum hydride was suspended in 500ml of anhydrous tetrahydrofuran, and 69.06g (0.28mole) of methyl 3- (3, 4-dichlorophenyl) -3-butanoate [ prepared according to step (a) above]was slowly added dropwise at 0 ℃ under a nitrogen atmosphere over 15 minutes]Solution in 500ml of anhydrous tetrahydrofuran. The reaction mixture was stirred at the same temperature for 30 minutes, then 500ml of water and 500ml of 10% w/v hydrogen were slowly addedAn aqueous sodium oxide solution. The mixture was stirred at room temperature for 1 hour. It is then filtered through Celite (trade mark) filter aid and the filtrate is extracted three times with 500ml of ethyl acetate each time. The combined organic extracts were dried over anhydrous magnesium sulfate. The solvent in the extract was distilled off under reduced pressure, and the resulting residue was dried under reduced pressure. The residuewas dissolved in 250ml of anhydrous dimethylformamide, and then 47.12ml (0.34mole) of triethylamine, 6.88g (0.06mole) of 4-dimethylaminopyridine and 50.96g (0.34mole) of t-butyldimethylsilyl chloride were sequentially added under ice-cooling. The mixture was then stirred under ice-cooling for 2 hours. At the end of the stirring, 1 l of ethyl acetate was added to the reaction mixture and the mixture was washed successively with ice-cooled 10% w/v aqueous hydrochloric acid and saturated aqueous sodium chloride solution. It was then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by flash column chromatography on silica gel using a gradient elution method with a mixture of hexane and ethyl acetate in a volume ratio of 50: 1 to 20: 1 as an eluent, to give 43.52g (yield 47%) of the title compound as a colorless oil. Nuclear magnetic resonance spectroscopy (400MHz,CDCl₃)δppm：

7.50(1H，doublet，J＝2.1Hz)；

7.38(1H，doublet，J＝8.1Hz)；

7.24(1H，doublet of doublets，

J＝8.1&2.1Hz)；

5.35(1H，singlet)；

5.16(1H，singlet)；

3.70(2H，triplet，J＝6.9Hz)；

2.67(2H，triplet，J＝6.9Hz)；

0.86(9H，singlet)；

0.00(6H, singlet).1(C) 4-tert-butyldimethylsilyloxy- (2R) - (3, 4-dichlorophenyl) butane-1, 2-diol

790mg (1.01mmole) of hydroquinidine 1, 4-naphthyridinediyldiether (hydroquinidine 1, 4-phthalazinediyldiether), 100.19g (0.30mole) of potassium ferricyanide (III),42.06g (0.30mole) potassium carbonate and 0.516ml (0.20mmole) osmium tetroxide (solution in 0.393M toluene) are dissolved in 500ml of tert-butanol and 500ml of water, and 33.61g (0.10mole) of 3- (3, 4-dichlorophenyl) -3-butenol tert-butyldimethylsilyl ether [ prepared according to step (b) above]are added while cooling at 0 deg.C]The mixture was stirred at 0 ℃ for 5 hours, at the end of the stirring 150g of sodium sulfite were added and the reaction mixture was stirred at room temperature for 1 hour, then it was extracted three times with 800ml of ethyl acetate each time, and the combined organic extracts were dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, and the resulting residue was purified by flash column chromatography on silica gel using a gradient elution method with a 5: 1 to 1: 1 volume ratio mixture of hexane and ethyl acetate as eluent to give 32.3g (yield 87%) of the title compound as a colorless oil with an optical purity of 97% ee [ α]]_D ²⁴+ 11.39(C ═ 1.01, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.57(1H，doublet，J＝2.1Hz)；

7.43(1H，doublet，J＝8.1Hz)；

7.24(1H，doublet of doublets，

J＝8.1&2.1Hz)；

5.00(1H，singlet)；

3.80(1H，doubled doublet of

doublets，J＝10.4，3.8&3.8Hz)；

3.5-3.7(3H，multiplet)；

2.51(1H，doublet of doublets，

J＝8.0&5.2Hz)；

2.37(1H，doubled doublet of

doublets，J＝15.0，11.1&4.0Hz)；

1.86(1H，doubled doublet of

doublets，J＝15.0，2.9&2.9Hz)；

0.89(9H，singlet)；

0.04(3H，singlet)；

-0.01(3H, singlet).1(d) 1-azido-4-tert-butyldimethylsilyloxy- (2R) - (3, 4-dichlorophenyl) -2-butanol

32.07g (87.8 mmoles) of 4-tert-butyldimethylsilyloxy- (2R) - (3, 4-dichlorophenyl) butane-1, 2-diol [ prepared as in step (C) above]And 1.07g (8.76mmole) of 4-dimethylaminopyridine were dissolved in 320ml of pyridine, and 10.19ml (0.132mole) of methanesulfonyl chloride was slowly dropped under ice-cooling. The mixture was stirred at the same temperature under nitrogen atmosphere for 2 hours. The reaction mixture is then poured into 1500ml of ice-cooled 10% w/v aqueous hydrochloric acid and extracted three times with 200ml of ethyl acetate each time. The combined organic extracts were washed with saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was dried under reduced pressure. It is then dissolved in 300ml of anhydrous dimethylformamide and 11.41g (0.18mole) of sodium azide are added. The mixture was heated at 120 ℃ for 4 hours under nitrogen atmosphere. At the end of the heating. The reaction mixture was cooled to room temperature, poured into 1000ml of saturated aqueous sodium chloride solution and then extracted three times with 500ml of ethyl acetate each time. Drying the combined organic extracts with anhydrous magnesium sulfate, and removing solvent by evaporation under reduced pressure at a ratio of 10: 1 to 5: 1The residue was purified by flash column chromatography on silica gel using a gradient elution method using a 1 volume ratio mixture of hexane and ethyl acetate as an eluent to give 29.3g (yield 85%) of the title compound as a colorless oil [ α]]_D ²⁴-48.56 (C ═ 1.04, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.59(1H，doublet，J＝2.2Hz)；

7.44(1H，doublet，J＝8.3Hz)；

7.24(1H，doublet of doublets，

J＝8.3&2.2Hz)；

5.12(1H，singlet)；

3.81(1H，doubled doublet of

doublets，J＝10.6，4.1&3.0Hz)；

3.51(1H，doubled doublet of

doublets，J＝10.6，10.6&2.8Hz)；

3.40(1H，doublet，J＝12.5Hz)；

3.31(1H，doublet，J＝12.5Hz)；

2.35(1H，doublet，of doublets，

J＝15.8，10.6&4.1Hz)；

1.91(1H，doublet of doublets，

J＝15.8，3.0&2.8Hz)；

0.88(9H，singlet)；

0.02(3H，singlet)；

-0.04(3H, singlet).1(e) 1-amino-4-tert-butyldimethylsilyloxy- (2R) - (3, 4-dichlorophenyl) -2-butanol

10.00g (25.6 mmoles) of 1-azido-4-tert-butyldimethylsilyloxy- (2R) - (3, 4-dichlorophenyl) -2-butanol [ prepared according to step (d) above]Dissolved in 100ml of tetrahydrofuran and 0.6ml of water, and 7.39g (28.2mmole) of triphenylphosphine was added to the resulting solution. The mixture was then stirred at 80 ℃ under nitrogen for 4 hours. After the stirring, the solvent was distilled off under reduced pressure, and hexane was added to the residueThe precipitated crystals were filtered off, the filtrate was concentrated by evaporation under reduced pressure, and the resulting residue was purified by flash column chromatography on silica gel using a gradient elution method using a mixture of dichloromethaneand methanol in a volume ratio of 30: 1 to 10: 1 as an eluent to give 3.83g (yield 41%) of the title compound [ α]as a colorless oil]_D ²⁴+ 3.94(C ═ 0.71, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.56(1H，doublet，J＝2.2Hz)；

7.42(1H，doublet，J＝8.6Hz)；

7.22(1H，doublet of doublets，

J＝8.6&2.2Hz)；

4.91(1H，broad singlet)；

3.73(1H，doubled doublet of

doublets，J＝10.3，4.6&3.7Hz)；

3.53(1H，doubled doublet of

doublets，J＝10.3，10.2&3.7Hz)；

2.91(1H，doublet，J＝13.1Hz)；

2.86(1H，doublet，J＝13.1Hz)；

2.16(1H，doublet，of doublets，

J＝14.6，10.2&4.6Hz)；

1.88(1H，doublet of doublets，

J＝14.6，3.7&3.7Hz)；

1.44(2H，broad singlet)；

0.87(9H，singlet)；

0.01(3H，singlet)；

0.04(3H, singlets). 1(f)2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethanol tert-butyldimethylsilyl ether

1.35g (3.71mmole) of 1-amino-4-tert-butyldimethylsilyloxy- (2R) - (3, 4-dichlorophenyl) -2-butanol [ prepared as in step (e) above]Dissolved in 50ml of benzene and in the resulting solutionTo this mixture were added 167mg (5.57mmole) of paraformaldehyde and 13mg of p-toluenesulfonyl chloride. The mixture was heated to reflux for 3 hours at 100 ℃ under nitrogen using a Dean-Stark instrument. At the end of the heating reflux, the solvent was distilled off under reduced pressure, and 100ml of ethyl acetate was added to the residue. The resulting solution was washed with a saturated aqueous solution of sodium hydrogencarbonate and dried over anhydrous magnesium sulfate. Distilling under reduced pressure to remove solvent to obtain 2- [ (5R) - (3, 4-dichlorophenyl) oxazolidin-5-yl]Ethyl tert-butyl dimethyl silyl ether. This compound was dissolved in 50ml of dichloromethane, and 0.62ml (4.45mmole) of triethylamine and 45mg (0.37mmole) of 4-dimethylaminopyridine were added to the resulting solution. Then, under ice-cooling, 1.03g (4.47mmole) of 3, 4, 5-trimethoxybenzoyl chloride was added, and the mixture was stirred at 0 ℃ for 1 hour. 100ml of methylene chloride was added to the reaction mixture, and the mixture was washed successively with a 10% w/v aqueous hydrochloric acid solution, a saturated aqueous solution of sodium hydrogencarbonate and saturated aqueous solution of sodium chloride. It was dried over anhydrous magnesium sulfate. The solvent is distilled off under reduced pressure and the ratio of the solvent to the solvent is from 1: 5 to 2: 1The residue was purified by flash column chromatography on silica gel using a gradient elution method using a mixture of ethyl acetate and hexane in volume ratio as eluent to give 1.27g (60% yield) of the title compound as a white amorphous substance [ α]]_D ²⁴+ 61.73(C ═ 1.39, methanol) 1(g)2[ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]Ethanol methanesulfonate

3.95g (6.92mmole) of 2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]Ethanol tert-butyldimethylsilyl ether [ prepared according to step (f) above]Dissolved in 70ml of a mixture of acetic acid, tetrahydrofuran and water in a volume ratio of 3: 1. Themixture was heated at 80 ℃ for 8 hours under nitrogen atmosphere. At the end of the heating, the solution was neutralized with a saturated aqueous solution of sodium hydrogencarbonate and extracted with ethyl acetate. The organic layer was then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was dissolved in 30ml of pyridine. To the resulting solution were added 70mg (0.57mmole) of 4-dimethylaminopyridine and 0.66ml (8.53mmole) of methanesulfonyl chloride under ice-cooling, and the mixture was stirred at 0 ℃ for 2 hours under nitrogen atmosphere. At the end of the stirring, the reaction mixture is poured into 200ml of iceThe combined organic extracts were washed with saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulphate, the solvent was evaporated off under reduced pressure and the residue was purified by flash column chromatography on silica gel using a gradient eluent with a mixture of hexane and ethyl acetate in a volume ratio of 5: 1 to 1: 1 to give 3.02g (82% yield) of the title compound as a white amorphous substance [ α]]_D ²⁴+ 53.1(C-1.0, methanol) 1(h)1- {2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]Ethyl } -4-phenylpiperidine-4-carboxamide

150mg (0.28mmole) of 2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]Ethanol ASulfonate [ prepared according to the above step (g)]]And 75mg (0.31mmole) of 4-phenylpiperidine-4-carboxamide hydrochloride in 3ml of anhydrous dimethylformamide, to the solution 71mg (0.85mmole) of sodium hydrogencarbonate and 70mg (0.42mmole) of potassium iodide were added, the mixture was heated at 80 ℃ for 6 hours under a nitrogen atmosphere, at the end of the heating, 50m of 1 saturated aqueous solution of sodium chloride was added to the reaction mixture, which was then extracted three times with 50ml of ethyl acetate eachtime, the organic extracts were combined and dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, a mixture of dichloromethane and methanol in a volume ratio of 10: 1 was used as a developing agent, and the resultant residue was subjected to silica gel thin layer chromatography to obtain 127mg (yield: 71%) of the title compound as a white amorphous substance [ α]]_D ²⁴+ 25.2(C ═ 0.48, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.50-7.10(8H，multiplet)；

6.67(2H，singlet)；

5.30-4.85(2H，multiplet)；

5.18(2H，singlet)；

4.13-3.70(2H，multiplet)；

3.87(3H，Singlet)；

3.85(6H，singlet)；

2.67-1.93(12H, multiplex). Infrared absorption Spectrum v_max(KBr)cm^-1: 2940, 1678, 1640, 1584, 1456, 1416, 1236, 1128. Elemental analysis:

calculated value：

：60.77％；：5.83％；：6.45％；：

10.89％；

Actually measuring:：60.63％；：5.94％；：6.39％；：

10.93% Mass Spectrometry (FAB) m/z: 642(M +)⁺

The following compounds of examples 2-4 were prepared in the same manner as in example 1 above.

Example 21- {2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]Ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide) in 76% yield [ α]]_D ²⁴+ 19.2(c 1.05, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.60-7.10(8H，multiplet)；

6.71(2H，broad singlet)；

5.50-4.90(2H，multiplet)；

3.88(9H，singlet)；

3.40-1.40(20H, multiplex). Infrared absorption spectrum v_max(KBr)cm^-1：

2938, 1633, 1584, 1464, 1416, 1236, 1128. Elemental analysis:

calculated value：

：61.05％；：6.29％；：6.10％；：

10.30％；

Actually measuring:：60.66％；：6.25％；：5.80％；：

10.65％。

example 3

1- {2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethyl

Oxybenzoyl) oxazolidin-5-yl ethyl } -4- (pyrrolidin-1-ylcarbonyl)

Yield of 4-phenylpiperidine 82% [ α]]_D ²⁴+ 23.2(c 0.49 methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.52-7.40(2H，multiplet)；

7.33-7.00(6H，multiplet)；

6.68(2H，singlet)；

5.30-4.85(2H，multiplet)；

4.09-3.65(2H，multiplet)；

3.87(3H，singlet)；

3.86(6H，singlet)；

3.56-3.41(2H，broad singlet)；

2.89-2.60(4H，multiplet)；

2.48-2.29(4H，multiplet)；

2.20-1.98(10H, multiplex). Infrared absorption spectrum v_max(KBr)cm^-1：

2948, 1625, 1584, 1464, 1415, 1235, 1128. Elemental analysis:

calculated value：

：62.98％；：6.28％；：5.95％；：

10.04％；

Actually measuring:：63.01％；：6.43％；：5.97％；：

9.71 percent. Mass Spectrometry (FAB) m/z: 696(M + H)⁺

Example 41- {2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) -oxazolidin-5-yl]Ethyl } -4-morpholinocarbonyl-4-phenylpiperidine in 63% yield [ α]]_D ²⁴+ 20.5(c ═ 1.04, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.60-7.10(8H，multiplet)；

6.70(2H，singlet)；

5.40-4.90(2H，multiplet)；

3.87(9H，singlet)；

4.10-1.40(2H, multiplex); infrared absorption spectrum v_max(KBr)cm^-1：

2966, 1637, 1584, 1455, 1416, 1233, 1128. Elemental analysis:

calculated value：

：61.58％；：6.15％；：5.82％；：

9.83％；

Actually measuring:：61.47％；：6.62％；：5.45％；：

9.67 percent. Mass Spectrometry (FAB) m/z: 712(M + H)⁺

Examples 5 to 40

The compounds represented by the following formulas (A-1) and (A-2) can also be prepared in the same manner as described above. The meanings of the substituents shown in these formulae are summarized in tables A-1 and A-2. For convenience, the products of examples 1 to 4 are also listed in these tables.

TABLE A-1

TABLE A-1 (continuation)

TABLE A-1 (continuation)

TABLE A-1 (continuation)

TABLE A-1 (continuation)

TABLE A-2

TABLE A-2 (continuation)

TABLE A-2 (continuation)

TABLEA-2 (continuation)

Example 411{3- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) -oxazolidin-5-yl]propyl } -4-phenylpiperidine-4-carboxamide 41(a) methyl 4- (3, 4-dichlorophenyl) -4-chlorobutanoate

1.00g (6.80mmole) of dichlorobenzene and 0.72g (7.14mmole) of succinic anhydride are suspended in 3ml of dichloroethane and 1.36g (10.2mmole) of aluminum chloride powder are added. The mixture was stirred at 60 ℃ for 3 hours. At the end of the stirring, the reaction mixture was cooled with ice and 1N aqueous hydrochloric acid was added. And then extracted with dichloromethane. The organic extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The residue obtained is dissolved in 30ml of methanol and 0.20ml of aqueous sulfuric acid solution is added. The solution was then heated to reflux for 2 hours, after which the reaction mixture was cooled to room temperature, poured into water and extracted with ether. The organic extract was washed successively with a saturated aqueous solution of sodium hydrogencarbonate and saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The residue was purified by column chromatography on silica gel using a gradient elution method using a mixture of hexane and diethyl ether at a volume ratio of 17: 3 to 7: 3 as an eluent to give 0.25g (yield 14%) of the title compound as light orange crystals. Nuclear magnetismResonance spectra (400MHz, CDCl)₃)δppm：

8.07(1H，doublet，J＝2Hz)；

7.81(1H，doublet of doublets，

J＝2&8Hz)；

7.56(1H，doublet，J＝8Hz)；

3.71(3H，singlet)；

3.27(2H，triplet，J＝7Hz)；

2.78(2H, triplet, J ═ 7 Hz). 41(b) methyl 4- (3, 4-dichlorophenyl) -4-pentenoate

330mg (0.92mmole) of methyltriphenylbromide and 105mg (0.94mmole) of potassium tert-butoxide are suspended in 4ml of anhydrous benzene and the mixture is stirred under a stream of nitrogen at room temperature for 4 hours. 200mg of 4- (3, 4-dichlorophenyl) -4-oxobutyric acid methyl ester [ prepared according to the above step (a)]]A solution prepared by dissolving in 1ml of benzene was added to the reactionThe mixture was then stirred for 18 hours. At the end of the stirring, the reaction mixture was filtered through Celite (trade mark) filter aid and washed with diethyl ether. The filtrate was concentrated by evaporation under reduced pressure. The resulting residue was purified by silica gel column chromatography using a 23: 2 volume ratio mixture of hexane and diethyl ether as an eluent to give 95mg (64% yield) of the title compound as a pale yellow oil. Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.48(1H，doublet，J＝2Hz)；

7.40(1H，doublet，J＝8Hz)；

7.23(1H，doublet of doublets，

J＝2&8Hz)；

5.32(1H，singlet)；

5.14(1H，singlet)；

3.67(3H，singlet)；

2.79(2H，triplet，J＝8Hz)；

2.48(2H, triplet, J ═ 8 Hz). 41(C)4- (3, 4-dichlorophenyl) -4-penten-1-ol tert-butyldimethylsilyl ether

Except that methyl 4- (3, 4-dichlorophenyl) -4-pentenoate [ was used as in step (b) above) Preparation of]In addition, the title compound was obtained in 93% yield by operating in a similar manner to the procedure described in example 1 (b). Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.49(1H，doublet，J＝2Hz)；

7.38(1H，doublet，J＝9Hz)；

7.24(1H，doublet of doublets，

J＝2&9Hz)；

5.30(1H，singlet)；

5.13(1H，doublet，J＝1Hz)；

3.62(2H，triplet，J＝6Hz)；

2.52(2H，triplet，J＝8Hz)；

1.60-1.68(2H，multiplet)；

0.90(9H，singlet)；

0.04(6H, singlets). 41(d) (2R) -5- (tert-butyldimethylsilyloxy) -2- (3, 4-dichlorophenyl) pentane-1, 2-diol

Except that 4- (3, 4-dichlorophenyl) -4-penten-1-ol tert-butyldimethylsilyl ether [ prepared by the above step (C)]]In addition, by operating in a similar manner to the procedure described in example 1(C), the title compound was obtained in 90% yield with an optical purity of 98% ee [ α]]_D ²⁴-2.08(C ═ 0.48, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.56(1H，doublet，J＝2Hz)；

7.41(1H，doublet，J＝8Hz)；

7.23(1H，doublet of doublets，

J＝2&8Hz)；

4.96(1H，singlet)；

3.53-3.70(4H，multiplet)：

1.98-2.14(3H，multiplet)：

1.35-1.57(2H，multiplet)；

0.91(9H，singlet)：

0.082(3H，singlet)；

0.078(3H, singlet). 41(e) (2R) -1-azido-5- (tert-butyldisilyloxy) -2- (3, 4-dichlorophenyl) -2-pentanol

Except that (2R) -5- (tert-butyldimethylsilyloxy) -2- (3, 4-dichlorophenyl) pentane-1, 2-diol [ prepared as in step (d) above]is used]Otherwise, the same procedure as in example 1(d)) Similar procedure, the title compound was obtained in 86% yield [ α]]_D ²⁴-48.2(C ═ 0.61, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.58(1H，doublet，J＝2Hz)；

7.42(1H，doublet，J＝9Hz)；

7.23(1H，doublet of doublets，

J＝2&9Hz)；

4.93(1H，singlet)；

3.67(1H，multiplet)；

3.58(1H，multiplet)；

3.43(1H，doublet，J＝12Hz)；

3.31(1H，doublet，J＝12Hz)；

2.13(1H，multiplet)；

2.04(1H，multiplet)；

1.54(1H，multiplet)；

1.40(1H，multiplet)；

0.91(9H，singlet)

0.09(3H，singlet)

0.08(3H, singlets). 41(f) (2R) -1-amino-5- (tert-butyldimethylsilyloxy) -2- (3, 4-dichlorophenyl) -2-pentanol

Prepared as described in step (e) above, except that (2R) -1-azido-5- (tert-butyldimethylsilyloxy) -2- (3, 4-dichlorophenyl) -2-pentanol [ is used]The title compound was obtained in 76% yield by operating in a similar manner to the procedure described in example 1(e) [ α]_D ²⁴-8.13 (C ═ 0.48, methanol)Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.54(1H，doublet，J＝2Hz)；

7.40(1H，doublet，J＝9Hz)；

7.21(1H，doublet of doublets，

J＝2&9Hz)；

4.57(1H，broad singlet)；

3.50-3.62(2H，multiplet)；

2.96(1H，doublet，J＝13Hz)；

2.82(1H，doublet，J＝13Hz)；

1.93(1H，multiplet)；

1.80(1H，multiplet)；

1.33-1.60(2H，multiplet)；

0.89(9H，singlet)；

0.04(6H, singlets). 41(g)3- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]-1-propanol tert-butyldimethylsilyl ether

Except that (2R) -1-amino-5- (tert-butyldimethylsilyloxy) -2- (3, 4-dichlorophenyl) -2-pentanol [ is used, the preparation is carried out in the above step (f)]In addition, the title compound was obtained in 48% yield by operating in a similar manner to the procedure described in example 1(f) [ α]_D ²⁴+ 37.73(C ═ 0.44, methanol) 41(h)3- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]-1-propanol methanesulfonate

Except using 3- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]-1-propanol tert-butyldimethylsilyl ether [ prepared according to step (g) above]In addition, the title compound was obtained in 93% yield by operating in a similar manner to the procedure described in example 1 (g).[α]_D ²⁴+ 52.90(C ═ 0.62, methanol) 41(i)1- {3- (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]Propyl } -4-phenylpiperidine-4-carboxamide

Except using 3- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]-1-propanol methanesulfonate [ prepared as described in step (h) above]In addition, in a similar manner to that described in example 1(h), a yield of 66% was obtainedRate preparation of the title compound [ α]]_D ²⁴+ 35.9(C ═ 0.48, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.60-7.10(8H，multiplet)；

6.68(2H，broad singlet)；

5.40-4.90(4H，multiplet)；

3.88(9H，singlet)；

3.87(9H，singlet)

4.10-1.10(16H, multiplex). Infrared absorption Spectrum v_max(KBr)cm^-1：

3440, 3353, 2940, 1676, 1641, 1585 element analysis:

calculated value：

：61.35％；：6.06％；：6.31％；：

10.65％；

Actually measuring:：61.81％；：6.22％；：6.50％；：

10.26 percent. Mass Spectrometry (FAB) m/z: 656(M + H)⁺

Examples 42 to 50

A compound represented by the following formula (A-3) was prepared in the same manner as in example 41 above. The various substituents shown in the formula are summarized in Table A-3. For convenience, the products of example 41 are also listed in the table.

TABLE A-3

TABLE A-3 (continuation)

TABLE A-3 (continuation)

Example 51

1- {2- (2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4-carboxamide (Compound 2-1969)51(a)3- (3, 4-dichlorophenyl) -3, 4-epoxy-1-butanol tert-butyldimethylsilyl ether

3.00g (9.05mmole) of 3- (3, 4-dichlorophenyl) -3-butenol tert-butyldimethylsilyl ether prepared as described in example 1(b)]Dissolved in 60ml of methylene chloride, and to the solution were added 2.52g (30.0mmole) of sodium hydrogencarbonate and 3.88g (15.7mmole) of 3-chloroperbenzoic acid (content: 70%). The mixture was stirred at room temperature for 3 hours. At the end of the stirring, the reaction mixture was diluted with dichloromethane and washed with 1N aqueous sodium hydroxide solution and saturated aqueous sodium chloride solution. The organic layer was thendried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by column chromatography on silica gel using gradient elution with hexane and ether at a volume ratio of 24: 1 to 19: 1 as an eluent to give 2.70g of the title compound. Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.47(1H，doublet，J＝2Hz)；

7.38(1H，doublet，J＝8Hz)；

7.21(1H，doublet of doublets，

J＝2&8Hz)；

3.57-3.72(2H，multiplet)；

3.01(1H，doublet，J＝5Hz)；

2.68(1H，doublet，J＝5Hz)；

2.27(1H，multiplet)；

2.01(1H，multiplet)；

0.84(9H，singlet)；

-0.016(3H，singlet)；

-0.024(3H, singlet). 51(b)4- (tert-butyldimethylsilyloxy) -2- (3, 4-dichlorophenyl-1- [ N- (tert-butoxycarbonyl) -N- (2-hydroxyethyl) amino]-2-butanol

1.50g (4.32mmole) of 3- (3, 4-dichlorophenyl) -3, 4-epoxy-1-butanol tert-butyldimethylsilyl ether [ prepared according to step (a) above]and 1.84g (17.3mmole) of lithium perchlorate are dissolved in 30ml of nitrile. The mixture was stirred at room temperature for 10 minutes under nitrogen atmosphere. 2.11g (34.5mmole) of 2-aminoethanol are added to the reaction mixture and the mixture is heated under reflux for 5 hours. At the end of stirring, the reaction mixture was cooled to room temperature, diluted with ethyl acetate and washed with saturated aqueous solution of sodium chloride. The organic layer was partitioned and dried over anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure.

The resulting residue was dissolved in 30ml of methylene chloride, and 0.89ml (6.42mmole) of triethylamine and 943mg (4.32mmole) of di-tert-butyl dicarbonate were added to the resulting solution. The mixture was stirred at room temperature for 16 hours. At the end of the stirring, the reaction mixture was poured into water and extracted with dichloromethane. The extract was then washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The residue was purified by column chromatography on silica gel using a mixture of hexane and ethyl acetate in a volume ratio of 3: 2 as an eluent to give 1.94g of the title compound. Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.30-7.75(3H，multiplet)；

5.30 and 5.57 (total 1H, each wide singlet);

3.05-4.00(9H，multiplet)；

2.00-2.40(2H，multiplet)；

1.53(9H，singlet)；

0.94(9H，singlet)；

0.09(3H，singlet)；

0.07(3H, singlet); infrared absorption spectrum v_max(KBr)cm^-1: 3298, 2955, 2936, 2885, 2857, 1659. Mass spectrometry analysis: (FAB) m/z: 508(M + H)⁺51(c)2- [ 4-tert-Butoxycarbonyl-2- (3, 4-dichlorophenyl) morpholin-2-yl]Ethanol tert-butyl dimethyl silyl ether

10.4g (20.5 mmoles) of 4- (tert-butyldimethylsilyloxy) -2- (3, 4-dichlorophenyl) -1- [ N- (tert-butoxycarbonyl-N- (2-hydroxyethyl) amino group]-2-Butanol [ prepared according to step (b) above]And 8.03g (30.6mmole) of triphenylphosphine were dissolved in 180ml of anhydrous toluene and a solution of 5.33g (30.6mmole) of diethyl azodicarboxylate in 20ml of toluene was added dropwise under a nitrogen atmosphere at room temperature. The mixture was stirred for 2 hours. At the end of the stirring, the reaction mixture was poured into aqueous ammonium chloride solution and extracted with ethyl acetate. The mixture was then washed with a saturated aqueous solution of sodium chloride. The organic extract was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by column chromatography on silica gel using a gradient elution method using a mixture of hexane and ethyl acetate in a volume ratio of 23: 2 to 9: 1 as an eluent to give 8.85g of the title compound. Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.56(1H，broad singlet)；

7.43(1H，doublet，J＝9Hz)；

7.28(1H，doublet of doublets，

J＝2&9Hz)；

4.20-4.55(1H，borad singlet)；

3.00-3.80(8H，multiplet)；

1.80-2.10(2H，multiplet)；

1.35-1.60(9H，broad singlet)；

0.85(9H，multiplet)；

0.01(6H, singlets). Infrared absorption spectrum v_maxcm^-1()：

2957, 2931, 2859, 1730, 1687. Mass spectrometry analysis: (FAB) m/z: 490(M + H)⁺51(d)2- [2- (3, 4-dichlorophenyl) morpholin-2-yl]Ethanol

7.80g (15.9mmole) of 2- [ 4-tert-butoxycarbonyl-2- (3, 4, dichlorophenyl) -morpholin-2-yl]Ethanol t-butyldimethylsilyl ether [ prepared according to the above step (C)]]Dissolved in 150ml of dichloromethane and 7.05g (35.5mmole) of B-bromocatechol borane were added. The mixture was stirred at room temperature for 2 hours under a nitrogen stream. At the end of the stirring, 150ml of water were added to the reaction mixture, which was then stirred for a further 2 hours. The reaction mixture was basified by the addition of 1N aqueous sodium hydroxide solution. It was extracted with dichloromethane and the extract was washed with saturated aqueous solution of sodium chloride, the solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography using a mixture of dichloromethane and methanol at a volume ratio of 19: 1 to 17: 3 as an eluent to give 4.40g of the title compound. Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.51(1H，doublet，J＝2Hz)；

7.48(1H，doublet，J＝8Hz)；

7.24(1H，doublet of doublets，

J＝2&8Hz)；

3.76(1H，doublet of triplets，

J＝3&12Hz)；

3.66(1H，multiplet)；

3.58(2H，triplet，J＝6Hz)；

3.36(1H，doublet，J＝13Hz)；

3.11(1H，doublet，J＝13Hz)；

2.97(1H，multiplet)；

2.79(1H，doublet of triplets，

J＝3&13Hz)；

2.14(1H，doublet of triplets，

J＝6&15Hz)；

1.79(1H，doublet of triplets，

J ═ 6&15Hz)51(e)2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethanol

1.28g (4.63mmole) of 2- (2- (3,4-dichlorophenyl) morpholin-2-yl]Ethanol [ prepared according to step (d) above)]Dissolved in 30ml of methylene chloride, and to the resulting solution were added 2.66g (26.3mmole) of triethylamine, 1.28g (5.55mmole) of 3, 4, 5-trimethoxybenzoyl chloride and 5mg of 4-dimethylaminopyridine. The mixture was stirred at room temperature for 6 hours. At the end of the stirring, the reaction mixture was poured into aqueous sodium bicarbonate and extracted with dichloromethane. The extract was washed with a saturated aqueous solution of sodium chloride. The organic extract was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was subjected to silica gel column chromatography using a gradient elution method using a mixture of dichloromethane and acetone in a volume ratio of 4: 1 to 7: 3 as an eluent to give 1.72g of the title compound. Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

6.80-7.80(3H，multiplet)；

6.47(2H，singlet)；

3.40-4.80(8H，multiplet)；

3.84 and 3.86 (total 9H, each singlet);

1.75-2.25(2H, multiplex). Infrared absorption spectrum v_maxcm^-1(KBr)3429，2940，2838，

1630, 1585. Mass spectrometry analysis: (EI) m/z: 469(M)⁺51(f)2- [2-3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl) ethanol methanesulfonate]

388mg (0.83mmole) of 2- [2- (3, 4-dichlorophenyl) -4-3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethanol [ prepared according to the above step (e)]]Dissolved in 5ml of dichloromethane, and to the resulting solution 126mg (1.25mmole) of triethylamine and 0.078ml (1.01mmole) of methanesulfonyl chloride were added. Mixing the mixtureStirred at room temperature for 2 hours. The reactionmixture was diluted with dichloromethane and then washed sequentially with a 1N aqueous hydrochloric acid solution and a saturated aqueous solution of sodium chloride. The organic extract was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. Purifying the residue by silica gel column chromatography using a gradient elution method using a mixture of hexane and ethyl acetate at a volume ratio of 1: 4 to 0: 1 as an eluentThis gave 424mg of the title compound. Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

6.90-7.80(3H，multiplet)；

6.52(2H，singlet)；

3.40-4.35(8H，multiplet)；

3.86 and 3.87 (total 9H, each singlet);

2.93(3H，singlet)；

2.10-2.55(2H, multiplex). Infrared absorption spectrum v_maxcm^-1(RBv)：

2999, 2966, 2939, 2875, 1634, 1585. Mass Spectrometry (FAB) m/z: 548(M + H)⁺51(g)1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } -4-phenylpiperidine-4-carboxamide

200mg (0.36mmole) of 2- [2-3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethanol methanesulfonate [ prepared as described in step (f) above]105mg (0.44mmole) of 4-phenylpiperidine-4-carboxamide hydrochloride, 100mg (1.19mmole) of sodium hydrogen carbonate and 100mg (0.60mmole) of potassium iodide are suspended in 2ml of dimethylformamide and the mixture is stirred at 80 ℃ for 6 hours under a nitrogen stream. The reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed successively with an aqueous solution of sodium thiosulfate, water and a saturated aqueous solution of sodium chloride. The organic extract was then evaporated with anhydrous sodium sulfate and the solvent was removed under reduced pressure. The resulting residue was subjected to thin layer chromatography using a 9: 1 mixture of dichloromethane and methanol as a developing solvent, followed by crystallization from hexane to give 205mg (yield 86%) of the titled compound.Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

6.80-7.75(8H，multiplet)；

6.48(2H，singlet)；

5.18(2H，singlet)；

1.80-4.70(18H，multiplet)；

3.83 and 3.85 (total 9H, each singlet). Infrared absorption spectrum v_maxcm^-1(KBr)：

3440，3356，2937，2831，1679，1631，

1584. Mass Spectrometry (FAB) m/z: 656(M + H)⁺Elemental analysis:

calculated value：

：62.02％；：6.00％；：6.38％；：

10.76％；

Actually measuring:：61.54％；：6.07％；：6.25％；：

11.35％。

the following compounds of examples 52 to 69 were prepared in the same manner as in example 1 above.

Example 52

1{2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide) (compound No.2-1971) yield: 84% Mass Spectrometry (FAB) m/z: 684(M + H)⁺Elemental analysis:

calculated value：

：63.16％；：6.33％；：6.14％；：

10.36％；

Actually measuring:：63.28％；：6.64％；：5.79％；：

9.96％。

example 53

1{2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } -4-phenyl-4- (pyrrolidin-1-ylcarbonyl) piperazine (compound No.2-1972) yield: 76% Mass Spectrometry (FAB) m/z: 710(M + H)⁺Elemental analysis:

calculated value：

：64.06％；：6.39％；：5.90％；：

9.95％；

Actually measuring:：63.62％；：6.37％；：5.75％；：

9.96％。

example 54

1{2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } -4-morpholinocarbonyl-4-phenylpiperidine (compound No. 2-1973)) Yield: 68% Mass Spectrometry (FAB) m/z: 726(M + H)⁺Elemental analysis:

calculated value：

：62.65％；：6.25％；：5.77％；：

9.73％；

Actually measuring:：62.26％；：6.18％；：5.66％；：

9.87％。

example 55

1{2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } spiro [ isobenzofuran-1 (3H), 4' -piperidine](Compound No.2-2006) yield: 63% Mass Spectrometry (FAB) m/z: 641(M + H)⁺Elemental analysis:

calculated value：

：63.47％；：5.98％；：4.35％；：

11.02％；

Actually measuring:：63.04％；：6.10％；：4.24％；：

11.10％。

example 56

1{2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } -1-methanesulfonylspiro (indoline-3, 4' -piperidine) (compound No.2-2014) yield: 85% Mass Spectrometry (FAB) m/z: 718(M + H)⁺)Elemental analysis:

calculated value：

：58.49％；：5.75％；：5.85％；：

9.87％；：4.46％。

Actually measuring:：58.26％；：5.8O％；：5.74％；：

10.02％；：4.33％。

example 57

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } spiro [ benzo [ C]]Thiophene-1 (3H),4' -piperidines](Compound No.2-2008) yield: 78% Mass Spectrometry (FAB) m/z: 657(M + H)⁺Elemental analysis:

calculated value：

：60.44％；：5.97％；：4.15％；：

10.49％；：4.74％；

Actually measuring:：60.68％；：5.95％；：3.92％；：

10.60％；：4.85％。

example 58

1{2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } spiro [ benzo [ C]]Thiophene-1 (3H), 4' -piperidines]2-oxide (compound 2-2010) yield: 60% Mass Spectrometry (FAB) m/z: 673(M + H)⁺Elemental analysis:

calculated values:：

：60.62％；：5.69％；：4.16％；：10.53％；：4.76％；

actually measuring:：60.50％；：5.94％；：4.09％；：10.35％；：4.71％。

example 59

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } spiro [ isoquinoline-1 (2H), 4' -piperidine]-3(4H) -one (compound No.2-2015) yield: 80% Mass Spectrometry (FAB) m/z: 668(M + H)⁺Elemental analysis:

calculated values:：

：62.87％；：5.88％；：6.29％；：10.61％；

actually measuring:：62.95％；：5.98％；：6.07％；：10.77％。

example 60

1- {2- [2- (3, 4-dichlorophenyl) -4- (2-pyridinecarbonyl) morpholin-2-yl]Ethyl } -4-phenylpiperidine-4-carboxamide (compound No.2-2353) yield: 73% Mass Spectrometry (FAB) m/z: 567(M + H)⁺Elemental analysis：

Calculated values:：

：62.50％；：5.77％；：9.72％；：12.30％；

actually measuring:：62.19％；：5.88％；：9.39％；：13.12％。

example 61

1- {2- [2- (3, 4-dichlorophenyl) -4- (2-pyridinecarbonyl) morpholin-2-yl]Ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide) (compound No.2-2355) yield: 70% Mass Spectrometry (FAB) m/z: 595(M + H)⁺Elemental analysis:

calculated values:：

：63.57％；：6.17％；：9.27％；：11.73％；

actually measuring:：63.34％；：6.26％；：9.23％；：11.97％。

example 62

1- {2- [2- (3, 4-dichlorophenyl) -4- (2-methoxybenzoyl) morpholin-2-yl]Ethyl } -4-phenylpiperidine-4-carboxamide (compound No.2-1585) yield: 75% Mass Spectrometry (FAB) m/z: 596(M + H)⁺Elemental analysis:

calculated values:：

：63.47％；：5.99％；：6.94％；：11.71％；

actually measuring:：63.02％；：6.12％；：6.74％；：12.97％。

example 63

1- {2- [2- (3, 4-dichlorophenyl) -4- (2-methoxybenzoyl) morpholin-2-yl]Ethyl } -4-phenylpiperidine- (N, N-dimethylformamide) (compound No.2586) yield: 77% Mass Spectrometry (FAB) m/z: 624(M + H)⁺Elemental analysis:

calculated values:：

：64.45％；：6.36％；：6.63％；：11.19％；

actually measuring:：64.29％；：6.42％；：6.68％；：11.57％。

example 64

1- {2- [2- (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl]Ethyl } -4-phenylpiperidine-4-carboxamide (compound No.2-1633) yield: 80% Mass Spectrometry (FAB) m/z: 596(M + H)⁺Elemental analysis

Calculated values:：

：63.47％；：5.99％；：6.94％；：11.71％；

actually measuring:：63.44％；：5.79％；：6.79％；：11.47％。

example 65

1- {2- [2- (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl]Ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide) (compound No.2-1635) yield: 80% Mass Spectrometry (FAB) m/z: 624(M + H)⁺Elemental analysis:

calculated values:：

：65.01％；：6.32％；：6.69％；：11.29％；

actually measuring:：64.79％；：6.47％；：6.42％；：10.93％。

example 66

1- {2- [2- (3, 4-dichlorophenyl) -4- (4-methoxybenzoyl) morpholin-2-yl]Ethyl } -4-phenylpiperidine-4-carboxamide (compound No.2-1681) yield: 94% Mass Spectrometry (FAB) m/z: 596(M + H)⁺Elemental analysis:

calculated values:：

：64.04％；：5.95％；：7.00％；：11.82％；

actually measuring:：63.67％；：5.97％；：6.70％；：12.20％。

example 67

1- {2- [2- (3, 4-dichlorophenyl) -4- (4-methoxybenzoyl)Morpholin-2-yl]Ethyl } -4-phenylpyridine-4- (N, N-di)Methylformamide (compound No.2-1683) yield: 78% Mass Spectrometry (FAB) m/z: 624(M + H)⁺Elemental analysis:

calculated values:：

：65.38％；：6.29％；：6.73％；：11.35％；

actually measuring:：65.32％；：6.94％；：6.61％；：10.97％。

example 68

1- {2- [2- (3, 4-dichlorophenyl) -4- (2-pyrazinylcarbonyl) morpholin-2-yl]Ethyl } -4-phenylpiperidine-4-carboxamide (compound No.2-2497) yield: 31% Mass Spectrometry (FAB) m/z: 568(M + H)⁺Elemental analysis:

calculated values:：

：59.39％；：5.67％；：11.87％；：12.09％；

actually measuring:：59.58％；：5.82％；：11.30％；：12.56％。

example 69

1- {2- [2- (3, 4-dichlorophenyl) -4- (2-pyrazinylcarbonyl) morpholin-2-yl]Ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide) (Compound No.2-2499)Yield: 33% Mass Spectrometry (FAB) m/z: 596(M + H)⁺Elemental analysis:

calculated values:：

：60.58％；：6.07％；：11.40％；：11.54％；

actually measuring:：60.57％；：5.95％；：9.97％；：12.88％。

example 70

1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl) -4-phenylpiperidine-4-carboxamide (Compound No.2-1969)70(a)1- (chloroacetyl) amino-4-tert-butyldimethylsilyloxy- (2R) - (3, 4-dichlorophenyl) -2-butanol

3.60g (9.88mmole) of 1-amino-4-tert-butyldimethylsilyloxy- (2R) - (3, 4-dichlorophenyl) -2-butanol [ prepared as described in example 1(e)]]1.64ml (11.8mmole) of triethylamine and 121mg (0.99mmole) of 4-dimethylaminopyridine are dissolved in 100ml of dichloromethane and 0.94(11.8mmole) of chloroacetyl chloride is added dropwise under ice cooling. The mixture was stirred at the same temperature for 2 hours. At the end of the stirring, 100ml of dichloromethane are added to the reaction mixture and the reaction mixture is filteredThe mixture was washed with ice-cooled 10% w/v aqueous hydrochloric acid, saturated aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution in this order. It was then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was subjected to flash silica gel column chromatography using a gradient elution method using a mixture of ethyl acetate and hexane in a volume ratio of 1: 5 to 1: 2 as an eluent, to give 3.32g (yield 76%) of the title compound as a colorless oil. Nuclear magnetic resonance spectroscopy (270MHz, CDCl)₃)δppm：

7.64(1H，doublet，J＝2.1Hz)；

7.47(1H，doublet，J＝8.4Hz)；

7.28(1H，doublet of doublets，J＝8.4&2.1Hz)；

7.03(1H，broad triplet)，

5.27(1H，singlet)；

4.04(2H, AB-quartet, J15.1 Hz, Δ δ 0.08 ppm);

3.81(1H，doublet of triplets，J＝10.5&3.7Hz)；

3.72(1H，doublet of doublets，J＝13.5&6.2Hz)；

3.53(1H，doublet of doublets，J＝10.9&2.3Hz)；

3.45(1H，doublet of doublets，J＝13.5&5.4Hz)；

2.24(1H，doublet of doublets，J＝14.8，10.9&4.1Hz)；

1.93(1H，doublet of triplets，J＝14.8&2.8Hz)；

0.92(9H，singlet)；

0.06(3H，singlet)；

0.00(3H, singlets). 70(b)2- [ (2R) - (3, 4-dichlorophenyl) -5-oxomorpholin-2-yl]ethanol tert-butyldimethylsilyl ether

219mg (5.48mmole) of sodium hydride (suspension in 60% w/v mineral oil) are suspended in 30ml of anhydrous tetrahydrofuran and, under ice-cooling, 1.61g (3.65mmole) of 1- (chloroacetyl) amino-4-tert-butyldimethylsilyloxy- (2R- (3, 4-dichlorophenyl) -2-butanol [ as described above]are slowly added dropwise over a period of 30 minutes

(a) Prepared]dissolved in 30ml of anhydrous tetrahydrofuran. The mixture was stirred at the same temperature for 4 hours. At the end of the stirring, the reaction mixture was poured into ice-cooled 10% w/v aqueous hydrochloric acid and extracted three times with 100ml of ethyl acetate each time. The combined organic extracts were washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was subjected to flash silica gel column chromatography using a mixture of ethyl acetate and hexane in a volume of 1: 4 to 2: 1 as an eluent to obtain 700mg (yield 47%) of the title compound.

[α]_D ²⁴Nuclear magnetic resonance spectrum (270MHz, CDCl) of +67.65(c 0.81 methanol)₃)δppm：

7.532(1H，doublet，J＝2.2Hz)；

7.526(1H，doublet，J＝8.1Hz)；

7.27(1H，doublet of doublets，J＝8.1&2.2Hz)；

6.76(1H，broad singlet)；

4.17(2H, AB-quartet, J17.3 Hz, Δ δ 0.24 ppm);

3.98(1H，doublet of doublets，J＝13.0&3.9Hz)；

3.76(1H，doublet of doublets，J＝13.0&2.0Hz)；

3.63(1H，multiplet)；

3.29(1H，multiplet)；

2.12(2H，multiplet)；

0.91(9H，singlet)；

0.04(3H，singlet)；

0.03(3H, singlets). 70(c)2- [ (2R) - (3, 4-dichlorophenyl) morpholin-2-yl]ethanol

580mg (1.43mmole) of 2- [ (2R) - (3, 4-dichlorophenyl) -5-oxomorpholin-2-yl]ethanol tert-butyldimethylsilyl ether [ prepared as in step (b) above]was dissolved in 6ml of anhydrous tetrahydrofuran. The solution is heated to reflux under a stream of nitrogen and 0.60ml (6.0mmole) of 10M borane-dimethyl sulfite complex are added dropwise. The mixture was stirred for 2 hours. At the end of the stirring, the solvent was distilled off under reduced pressure and 5ml of a 1N aqueous hydrochloric acid solution were added. The mixture was then stirred at 100 ℃ for 1 hour. The reaction mixture was air-cooled, basified by addition of a 1N aqueous solution of sodium hydroxide, diluted with a saturated aqueous solution of sodium chloride, and extracted with ethyl acetate. The organic extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The residue was purified by column chromatography on silica gel using a gradient elution method using a mixture of dichloromethane and methanol in a volume ratio of 9: 1 to 17: 3 as an eluent to yield 360mg of the title compound.

[α]_D ²⁴= 16.22(c ═ 0.45, methanol)

NMR spectroscopy, IR spectroscopy and mass spectroscopy were consistent with those for the racemic product described in example 51 (d). 70(d)2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethanol

The title compound was obtained in 92% yield by the same procedures as described in example 51(e) except for using 2- [ (2R) - (3, 4-dichlorophenyl) morpholin-2-yl]ethanol [ prepared as in step (c) above].

[α]_D ²⁴30.65(c is 0.56 methanol)

NMR spectroscopy, IR spectroscopy and mass spectroscopy were consistent with those for the racemic product described in example 51 (e). 70(e)2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethanol methanesulfonate

30.0g (63.8mmole) of 2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethanol [ prepared according to step (d) above)]Dissolved in 500ml of dichloromethane. To the mixture were added 11.5ml (83.0mmole) of triethylamine and 5.93ml (76.6 ml) in this order under ice-coolingmmole) methanesulfonyl chloride, the mixture was stirred at room temperature for 2 hours under an ammonia atmosphere. The reaction mixture was diluted with dichloromethane and washed with a 1N aqueous hydrochloric acid solution, a saturated aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate. The solvent is distilled off under reduced pressure andthe product is distilled off at a ratio of 1: 4 to 1: 9The residue was purified by column chromatography on silica gel using a mixture of an alkane and ethyl acetate as eluent to give 34.8g of the title compound [ α]]_D ²⁴+26.36(c ═ 0.66, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

6.90-7.80(3H，multiplet)；

6.52(2H，singlet)；

3.40-4.35(8H，multiplet)；

3.86&3.87 (9H total, each unimodal);

2.93(3H，singlet)；

2.10-2.55(2H, multiplex). Infrared absorption spectrum v_maxcm^-1(KBr)：

2999, 2966, 2939, 2875, 1634, 1585 mass spectrometry (FAB) m/z: 548(M + H)⁺70(f)1- {2- [ (2R- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } -4-phenylpiperidine-4-carboxamide

Except using 2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethanol methanesulfonate [ prepared as described in step (e) above]In addition, the title compound was obtained in 79% yield by operating in a similar manner to example 51(g) [ α]_D ²⁴= 7.53(c ═ 0.50, methanol)Elemental analysis:

calculated values:：

：61.85％；：6.01％；：6.36％；：10.74％；

actually measuring:：61.51％；：6.18％；：6.13％；：10.72％。

NMR, IR, and mass spectral analyses were consistent with the racemic product described in example 51 (g).

The following compounds of examples 71-74 were prepared by the same procedure as in example 70 above.

Example 71

1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide (Compound No. 2-1971)) yield 84% [ α]]_D ²⁴Elemental analysis of +7.04(c 0.45, methanol):

calculated values:：

：62.69％；：7.02％；：6.09％；：10.28％；

actually measuring:：62.37％；：6.42％；：5.94％；：10.72％。

example 72

1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } spiro [ benzo [ c]]Thiophene-1- (3H),4' -piperidines]Yield of-2-oxide (Compound No.2-2010) 66% [ α%]_D ²⁴Elemental analysis (2.50 (c 0.50, methanol):

calculated values:：

：60.62％；：5.69％；：4.16％；：10.53％；：4.76％；

actually measuring:：60.17％；：5.68％；：4.00％；：10.47％；：4.55％。

example 73

1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } spiro [ isoquinoline-1 (2H), 4' -piperidine]Yield of (E) -3(4H) -one (Compound No.2-2015) 75% [ α]]_D ²⁴Elemental analysis +2.58(c ═ 0.40, methanol):

calculated values:：

：62.87％；：5.88％；：6.29％；：10.61％；

actually measuring:：62.46％；：6.01％；：6.08％；：9.63％。

example 74

78% yield of 1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl } -4-phenylpiperidine-4- (N, N-dimethylformamide) (compound No.2-1635) [ α%]_D ²⁴Elemental analysis +9.67(c 0.50, methanol):

calculated values:：

：65.01％；：6.32％；：6.69％；：11.29％；

actually measuring:：64.84％；：6.46％；：6.52％；：11.58％。

example 75

1- {2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide (Compound No.3-10)

600mg of (1.12mmole)2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]Ethanol methanesulfonate [ prepared as described in example 1(g)]]318mg (1.23mmole) of spiro [ benzo [ c]]Thiophene-1 (3H), 4' -piperidines]- (2S) -oxide hydrochloride [ prepared as described in preparation 6]283mg (3.37mmole) of sodium bicarbonate, and 280mg (169mmole) of sodium iodide are suspended in 10ml of anhydrous dimethylformamide, and the mixture is heated at 80 ℃ for 8 hours under a nitrogen atmosphere. Then will beThe reaction mixture was poured into 100ml of a saturated aqueous solution of sodium chloride and extracted with ethyl acetate. The organic extract was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by column chromatography on silica gel using a gradient elution method using a mixture of dichloromethane and methanol in a volume ratio of 40: 1 to 20: 1 as an eluent, and then crystallized from diisopropyl ether to give 496mg of the title compound as white crystals.[α]_D ²⁴+41.0(c ═ 1, methanol) HPLC analysis

Column: YMC-Pack ODS-A (250X 4.6 mm. RTM.)

Eluent:：＝40∶60，0.1％

flow rate: 1.0ml/min

Retention time: 28.6min NMR spectra (400MHz, CDCl)₃)δppm：

7.1-7.6(7H，multiplet)；

6.70(2H，singlet)；

4.9-5.3 (total 2H, broad singlet);

4.32(1H，doublet，J＝16.7Hz)；

4.00(1H，doublet，J＝16.7Hz)；

3.7-4.2(2H，multiplet)；

3.87&3.89 (total 9H, each unimodal);

1.5-3.1(12H, multiplex). Infrared absorption spectrum v_maxcm^-1(KBr)：

2940, 1642, 1584, 1416, 1237, 1128. Mass Spectrometry (FAB) M/z659(M + H)⁺Elemental analysis

Calculated values:：

：59.28％；：5.58％；：4.19％；：4.79％；：10.60％；

actually measuring:：59.36％；：5.58％；：4.12％；：4.73％；：10.60％。

example 76

1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide (Compound No.3-42)76(a)4- (tert-butyldimethylsilyloxy) - (2R) - (3, 4-dichlorophenyl) -1- [ N- (tert-butoxycarbonyl) -N- (2-hydroxyethyl) amino]-2-butanol

39.9g (109mmole) of 4-tert-butyldimethylsilyloxy- (2R) - (3, 4-dichlorophenyl) butane-1, 2-diol [ prepared as described in example 1(c)]]Dissolved in 80ml of pyridine, and 31.3g (164mmole) of p-toluenesulfonyl chloride was added to the resulting solution. The mixture was stirred at room temperature under nitrogen atmosphere for 2 days. At the end of the stirring, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic extract was washed successively with water and saturated aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The residue obtained is dissolved in 600ml of acetonitrile and 35.0g (329mmole) of lithium perchlorate and 33.4g (547mmole) of 2-aminoethanol are added to the solution obtained. The mixture was heated to reflux for 16 hours. At the end of the heating, the reaction mixture was cooled to room temperature, diluted with ethyl acetate and washed with saturated aqueous solution of sodium chloride. The organic phase was separated and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was dissolved in 700ml of dichloromethane. To the resulting solution were added 22.8ml (164mmole) of triethylamine and 26.3g (120mmole)Di-tert-butyl dicarbonate, and the mixture is stirred at room temperature for 12 hours, then the reaction mixture is poured into water and extracted with dichloromethane, the organic extract is washed with saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate, the solvent is distilled off under reduced pressure, the residue obtained is subjected to silica gel column chromatography using a mixture of hexane and ethyl hexanoate in a volume ratio of 4: 1 to 7: 3 as eluent, using gradient elution to give 49.9g of the title compound [ α]]_D ²⁴+3.92(c ═ 0.72, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.30-7.75(3H，multiplet)；

5.30&5.57 (total 1H, each wide singlet);

3.05-4.00(9H，multiplet)；

2.00-2.40(2H，multiplet)；

1.53(9H，singlet)；

0.94(9H，singlet)；

0.09(3H，singlet)；

0.07(3H, singlet). Infrared absorption spectrum v_maxcm^-1(KBr)：

3420, 2957, 2933, 2885, 2861, 1687. Mass Spectrometry (FAB) m/z: 508(M + H)⁺76(b)2- [ 4-tert-Butoxycarbonyl- (2R) - (3, 4-dichlorophenyl) morpholin-2-yl]Ethanol tert-butyl dimethyl silyl ether

49.9g (98.1mmole) of 4-tert-butyldimethylsilyloxy- (2R) - (3, 4-dichlorophenyl) -1- [ N- (tert-butoxycarbonyl) -N- (2-hydroxyethyl) amino]-2-Butanol [ prepared according to step (a) above]And 30.9g (118mmole) of triphenylphosphine in 600ml of anhydrous toluene, 51.3g of a 40% w/v toluene solution containing 118mmole of diethyl azodicarboxylate was added dropwise to the resulting solution at room temperature under a nitrogen atmosphere, and the mixture was stirred for 2 hours, at the end of the stirring, the solvent was distilled off under reduced pressure, and the resulting residue was subjected to silica gel column chromatography purification using a gradient elution method with a mixture of hexane and ethyl acetate in a volume ratio of 47: 3 to 23: 2 as an eluent, to give 43.2g of the title compound [ α]]_D ²⁴+32.67(c ═ 0.60, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.56(1H，broad singlet)；

7.43(1H，doublet，J＝9Hz)；

7.28(1H，doublet of doublets，J＝2&9Hz)；

3.00-4.55(8H，multiplet)；

1.80-2.10(2H，multiplet)；

1.35-1.60(9H，broad singlet)；

0.85(9H，singlet)；

0.01(6H, singlets). Infrared absorption spectrum v_maxcm^-1()：

2957, 2931, 2859, 1687. Mass Spectrometry (FAB) m/z: 490(M + H)⁺76(c) (2R- (3, 4-dichlorophenyl) -2- (2-hydroxyethyl) morpholine hydrochloride

43.1g (87.9mmole) of 2- [ 4-tert-butoxycarbonyl- (2R) - (3, 4-dichlorophenyl) morpholin-2-yl]Ethanol tert-butyldimethylsilyl ether [ prepared according to step (b) above]Dissolving in 600ml of 4N hydrogen chloride in dioxane, stirring the mixture at 60 ℃ for 4 hours, distilling off the solvent under reduced pressure at the end of the stirring, adding diethyl ether to the residue, distilling off the solvent under reduced pressure, recrystallizing the residue from ethanol/ethyl acetate to give 24.1g of the title compound [ α]]_D ²⁴+48.07(c ═ 0.57, methanol) nuclear magnetic resonance spectrum (400MHz, hexafluorodimethyl sulfoxide) δ ppm:

8.60-9.80(2H，broad singlet)；

7.72(1H，singlet)；

7.70(1H，doublet，J＝9Hz)；

7.44(1H，doublet of doublets，J＝2&9Hz)；

4.53(1H，broad singlet)；

3.89(1H，doublet of triplets，J＝4&

13Hz)；

3.75(1H，doublet，J＝14Hz)；

3.68(1H，multiplet)；

3.30-3.45(2H，multiplet)；

2.93-3.13(3H，multiplet)；

2.09(1H，multiplet)；

1.90(1H, multiplex). Infrared absorption spectrum v_maxcm^-1(KBr)：

3378, 2966, 2893, 2812, 2783, 2724, 2656, 2530, 1598. MassSpectrometry (FAB) m/z: 276(M + H)⁺76(d)2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl (free form)]Ethanol

22.9g (82.9mmole) (2R- (3, 4-dichlorophenyl) -2- (2-hydroxyethyl) morpholine hydrochloride [ prepared as described in step (c) above]]Suspending in 500ml of dichloromethane, adding 27.6ml (199mmole) of triethylamine, 21.0g (91.0mmole) of 3, 4, 5-trimethoxybenzoyl chloride and 100mg of 4-dimethylaminopyridine to the suspension, and stirring the mixture at room temperature for 12 hours, pouring the reaction mixture into water and extracting with dichloromethane at the end of the stirring, washing the organic extract with a saturated aqueous solution of sodium chloride, drying it with anhydrous sodium sulfate, evaporating the solvent under reduced pressure, and purifying the residue by column chromatography on silica gel using a gradient elution method using a mixture of dichloromethane and acetone in a volume ratio of 4: 1 to 7: 3 as an eluent to obtain 30.0g of the title compound [ α]]_D ²⁴+30.65(c ═ 0.56, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

6.80-7.80(3H，multiplet)；

6.47(2H，singlet)；

3.40-4.80(8H，multiplet)；

3.84&3.86 (total 9H, each singlet);

1.75-2.25(2H, multiplex). Infrared absorption spectrum v_maxcm^-1(KBr)：

3429, 2940, 2838, 1630, 1585. Mass Spectrometry (EI) m/z: 469(M)⁺76(e) [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Acetaldehyde

0.88ml (10.1mmole) of oxalyl chloride was dissolved in 10ml of dichloromethane, and 5ml of a dichloromethane solution containing 0.79ml (11.1mmole) ofdimethyl sulfoxide was added dropwise to the above-obtained solution at-78 ℃ under a nitrogen atmosphere. The mixture was stirred for 30 minutes. To the resulting mixture was added dropwise 10ml of a mixture containing 950mg (2.02mmole) of 2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethanol [ prepared according to step (d) above)]And the mixture was stirred for 4 hours, when stirring was completed, 2.24ml (16.2mmole) of triethylamine was further added, and the mixture was stirred at room temperature for 2 hours, then the reaction mixture was poured into water and extracted with dichloromethane, the organic phase was washed successively with water and a saturated solution of sodium chloride, then dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure, and the resulting residue was subjected to silica gel column chromatography purification using a gradient elution method with a mixture of dichloromethane and acetone in a volume ratio of 23: 2 to 21: 4 as an eluent, to give 878mg of the title compound [ α]]_D ²⁴+36.15(c ═ 0.65, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

9.56(1H，singlet)；

6.90-7.80(3H，multiplet)；

6.50(2H，singlet)；

3.40-4.60(6H，multiplet)；

3.85-3.87 (9H total, each unimodal);

2.70-3.05(2H, multiplex). Infrared absorption spectrum v_maxcm^-1(KBr)：

2962, 2930, 2838, 1723, 1636, 1585. Mass Spectrometry (FAB) m/z: 468(M + H)⁺76(f)1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } spiro [ benzo [ c]]Thiophene-1 (3H) 4' -piperidines]- (2S) -oxides

15.00g (274mmole) of 2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethanol methanesulfonate [ prepared as described in example 70(e)]]7.76(30.1mmole) spiro [ benzo [ c]]Thiophene-1 (3H), 4' -piperidines]- (2S) oxide hydrochloride [ prepared as described in preparation example 6]，6.89g(82.0mmole) Sodium bicarbonate, and 6.81g (41.0mmole) of potassium iodide suspended in 150ml of anhydrous dimethylformamide, the mixture was heated at 80 ℃ for 8 hours under nitrogen, then the reaction mixture was poured into 400ml of saturated aqueous solution of sodium chloride and extracted with ethyl acetate, the organic extract was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, the resulting residue was subjected to silica gel column chromatography purification using a mixture of dichloromethane and methanol in a volume ratio of 40: 1 to 20: 1 as an eluent, and crystallized with hexane to give 15.5g of the title compound [ α]as white crystals]_D ²⁴+14.0(c ═ 1, methanol)HPLC analysis

Column: YMC-Pack ODS-A (250X 4.6 mm. RTM.)

Eluent:∶＝40∶60，0.1％

flow rate: 1.0ml/min

Retention time: 23.7min Nuclear magnetic resonance Spectroscopy (400MHz, CDCl)₃)δppm：

7.1-7.8(7H，multiplet)；

6.49(2H，broad singlet)；

4.31(1H，doublet，J＝16.8Hz)；

3.99(1H，doublet，J＝16.8Hz)；

3.86&3.84 (total 9H, each singlet);

3.3-4.0(6H，multiplet)

1.5-3.1(12H, multiplex). Infrared absorption spectrum v_maxcm^-1(KBr)：

2939, 1636, 1584, 1464, 1426, 1329, 1237, 1128. Mass Spectrometry (FAB) m/z: 673(M + H)⁺Elemental analysis:

calculated values:：

：59.82％；：5.76％；：4.10％；：4.7％；，10.39％；

actually measuring:：60.20％；：6.14％；：4.04％；：4.54％；10.38 percent. 76(g)1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4,5-Trimethoxybenzoyl) morpholin-2-yl]Ethyl } spiro [ benzo [ c]]Thiophene-1 (3H), 4' -piperidines]- (2S) -oxides

150mg (0.32mmole) [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]acetaldehyde [ prepared as in step (e) above]and 99mg (0.38mmole) of spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide hydrochloride [ prepared as in preparation 6]were dissolved in 1ml of methanol. To the resulting solution were added 100mg of molecular sieve 3A (powder) and 209mg (3.33mmole) of sodium cyanoborohydride, and the mixture was heated under reflux for 8 hours under a nitrogen atmosphere. The reaction mixture was filtered through Celire (trade mark) filter aid. The filtrate was poured into water and extracted with ethyl acetate. The organic extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by column chromatography on silica gel using a mixture of methylene chloride and methanol in a volume ratio of 97: 3 to 19: 1 as an eluent to give 184mg of the title compound. The physico-chemical properties of this product are in accordance with those of the product described in example 76 (f).

Example 771- {2- [ (2R) - (3, 4-dichlorophenyl) -4- [ (3-isopropoxyphenyl) acetyl]morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide (Compound No.3-811)77(a)2- { (2R) - (3, 4-dichlorophenyl) -4- [ (3-isopropoxyphenyl) acetyl]morpholin-2-yl } ethanol

1.03g (5.28mmole) of 3-isopropoxyphenylacetic acid was dissolved in 50ml of methylene chloride, and 1.10g (5.76mmole) of WSC-(Water-soluble carbodiimide-) 780mg (5.76mmole) of 1-hydroxybenzotriazole-1.61ml (11.5mmole) of triethylamine and 1.50g (4.80mmole) of (2R) - (3, 4-dichlorophenyl) -2- (2-hydroxyethyl) morpholine hydrochloride are prepared as described in example 76(c)]. The mixture was then stirred at room temperature under nitrogen for 15 hours. At the end of the stirring, a saturated aqueous solution of ammonium chloride was added to the reaction mixture, which was then extracted with ethyl acetate. The organic extract was washed with a saturated aqueous solution of sodium hydrogencarbonate and saturated aqueous solution of sodium chloride in this order, and then dried over anhydrous magnesium sulfate. The solvent is distilled off under reduced pressure,and subjecting the residue to silica gel column chromatography using a mixture of hexane and ethyl acetate in a volume ratio of 3: 1 to 2: 1 as an eluent to obtain 1.81g of the title compound [ α]]_D ²⁴-8.2(c ═ 0.60, methanol) nuclear magnetic resonance spectrum (270MHz, CDCl)₃)δppm：

6.45-7.57(7H，multiplet)；

4.74(1H，doublet，J＝13.9Hz)；

4.37-4.52(1H，multiplet)；

3.22-3.90(9H，multiplet)；

2.10-2.21(1H，broad singlet)；

1.87-2.09(2H，multiplet)；

1.30(3H，singlet)；

1.28(3H, singlet). Infrared absorption spectrum v_maxcm^-1(KBr)：

3693, 3622, 3589, 2981, 2934, 1645, 1608, 1583. Mass Spectrometry (FAB) m/z: 452(M + H)⁺77(b)2- { (2R) - (3, 4-dichloro-N-methyl-N-ethyl-N-methyl-N-ethyl-N-methyl-N-Phenyl) -4- [ (3-isopropoxyphenyl) acetyl]Morpholin-2-yl } ethanol methanesulfonate

1.81g (4.00mmole) of 2- { (2R) - (3, 4-dichlorophenyl) -4- [ (3-isopropoxyphenyl) acetyl]Morpholin-2-yl } ethanol [ prepared as described in step (a) above]Dissolved in 5ml of pyridine, and 45mg (0.40mmole) of 4-dimethylaminopyridine and 0.46ml (6.00mmole) of methanesulfonyl chloride were added to the resulting solution under ice-cooling. The mixture was stirred at 0 ℃ for 2 hours under nitrogen and at the end of stirring, the reaction mixture was poured into ice-cooled 10% w/v aqueous hydrochloric acid and extracted with ethyl acetate. Organic extractThe extract was washed with saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, and the obtained residue was purified by silica gel column chromatography using a mixture of hexane and ethyl acetate in a volume ratio of 1: 1 to 1: 2 as an eluent to give 2.00g of the title compound as a colorless oil [ α]]_D ²⁴-6.3(c ═ 0.70, methanol) nuclear magnetic resonance spectrum (270MHz, CDCl)₃)δppm：

6.51-7.59(7H，multiplet)；

4.40-4.63(2H，multiplet)；

3.17-4.26(9H，multiplet)；

2.93(3H，singlet)；

2.08-2.32(2H，multiplet)；

1.31(3H，singlet)；

1.29(3H, singlet). Infrared absorption spectrum v_maxcm^-1(KBr)：

2981, 2934, 1645, 1608, 1583. Mass Spectrometry (FAB) m/z: 530(M + H)⁺77(c)1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- [ (3-isopropoxyphenyl) acetyl]Morpholin-2-yl]Ethyl } spiro [ benzo [ c]]Thiophene-1 (3H), 4' -piperidines]- (2S) -oxides

630mg of (1.19mmole)2- { (2R) - (3, 4-dichlorophenyl) -4- [ (3-isopropoxyphenyl) acetyl]Morpholin-2-yl]Ethanol methanesulfonate [ prepared according to the above step (b)]]367mg (1.43mmole) of spiro [ benzo [ c]]Thiophene-1 (3H), 4' -piperidines]- (2S) -oxide hydrochloride [ prepared as described in preparation 6]299mg (3.56mmole) of sodium bicarbonate and 296mg (1.78mmole) of potassium iodide were suspended in 6ml of ethanolIn aqueous dimethylformamide under nitrogen atmosphereThis suspension was heated at 80 ℃ for 6 hours, at the end of the heating, the reaction mixture was poured into saturated aqueous sodium chloride solution and extracted with ethyl acetate, the organic extract was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, the residue obtained was purified by column chromatography on silica gel using a mixture of dichloromethane and methanol in a volume ratio of 25: 1 as eluent and then crystallized from hexane to give 400mg of the title compound in the form of white crystals having an alkane point of 85-88 ℃ [ α]]_D ²⁴+2.5(c ═ 0.51, methanol) HPLC analysis

Column: YMC-Pack ODS-A (250X 4.6 mm. RTM.)

Eluent:∶＝60∶40，0.1％

flow rate: 1.0ml/min

Retention time: 23.7min Nuclear magnetic resonance Spectroscopy (400MHz, CDCl)₃)δppm：

6.55-7.61(11H，multiplet)；

4.71(1H，doublet，J＝13.8Hz)；

4.40-4.51(1H，multiplet)；

4.31(1H，doublet，J＝16.8Hz)；

3.99(1H，doublet，J＝16.8Hz)；

3.25-3.85(8H，multiplet)；

2.56-2.97(2H，multiplet)；

2.01-2.45(6H，multiplet)；

1.88-2.45(2H，multiplet)；

1.48-1.59(1H，multiplet)；

1.30(3H，singlet)；

1.29(3H, singlet). Infrared absorption spectrum v_maxcm^-1(KBr)：

2975, 2923, 1645, 1607, 1582, 1047. Mass Spectrometry (FAB) m/z: 655(M + H)⁺Elemental analysis

Calculated values:：

：63.25％；：6.22％；：4.21％；：4.82％；：10.67％；

actually measuring:：62.96％；：6.38％；：4.08％；：4.71％；：10.41％。

example 781- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl]hexahydro-1, 4-oxazepin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide (Compound No.3-74)78(a)4- (tert-butyldimethylsilyloxy) - (2R) - (3, 4-dichlorophenyl) -1- [ N- (tert-butoxycarbonyl) -N- (3-hydroxypropyl) amino-2-butanol

Except that 5.00g (13.7mmole) of 4-tert-butyldimethylsilyloxy) - (2R) - (3, 4-dichlorophenyl) -butane-1, 2-diol [ prepared as in example 1(c)]]And 5.15g (68.6mmole) of 3-amino-1-propanol as starting material, in a manner similar to example 76(a), to give 6.00g of the title compound [ α]]_D ²⁴-1.31(c ═ 1.22, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.20-7.70(3H，multiplet)；

5.04&5.32 (total 1H, each unimodal);

3.15-3.85(9H，multiplet)；

1.95-2.30(2H，multiplet)；

1.65-1.85(2H，multiplet)；

1.45(9H，singlet)；

0.86(9H，singlet)；

-0.08&0.01 (total 6H, each singlet). Infrared absorption spectrum v_maxcm^-1()：

3432, 2957, 2885, 2861, 1675. Mass Spectrometry (FAB) m/z: 522(M + H)⁺78(b)2- [ 4-tert-Butoxycarbonyl- (2R) - (3, 4-dichlorophenyl) hexahydro-1, 4-oxazepin-2-yl]Ethanol tert-butyl dimethyl silyl ether

300mg (0.57mmole) of 4- (tert-butyldimethylsilyloxy) - (2R) - (3, 4-dichlorophenyl) -1- [ N- (tert-butoxycarbonyl) -N- (3-hydroxypropyl) amino]-2-Butanol [ prepared according to step (a) above]Dissolving in 2ml pyridine, adding 196mg (1.03mmole) of p-toluenesulfonyl chloride to the resulting solution, stirring the mixture at room temperature under nitrogen for 16 hours, at the end of the stirring, pouring the reaction mixture into water and extracting with ethyl acetate, washing the organic extracts with water and saturated aqueous sodium chloride solution in that order, drying with anhydrous sodium sulfate, evaporating the solvent under reduced pressure, dissolving the residue in 3ml 2-methyl-2-propanol, adding 67mg (0.58mmole) of potassium tert-butoxide to the solution, heating the mixture at 80 ℃ for 8 hours under nitrogen, at the end of the heating, cooling the reaction mixture to room temperature, pouring into water and extracting with ethyl acetate, washing the organic extracts with saturated aqueous sodium chloride solution and drying with anhydrous sodium sulfate, evaporating the solvent under reduced pressure, eluting with a mixture of hexane and ethyl acetate in a volume ratio of 47: 3 to 23: 2, and purifying the residue by gradient elution to obtain 56mg of the title compound [ α]]_D ²⁴+14.19(c ═ 0.74, methanol) nuclear magnetic resonance spectrum (270MHz, CDCl)₃)δppm：

7.17-7.65(3H，multiplet)；

3.10-4.10(8H，multiplet)；

1.75-2.30(4H，multiplet)；

1.37&1.44 (total 9H, each singlet);

0.82(9H，singlet)；

-0.07&0.05 (total 6H, each singlet). Mass Spectrometry (FAB) m/z: 504(M + H)⁺78(c)2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) hexahydro-1, 4-oxazepin-2-yl]Ethanol methanesulfonate

Except using 2- [ 4-tert-butoxycarbonyl- (2R) - (3, 4-dichlorophenyl) hexahydro-1, 4-oxazepin-2-yl]Ethanol tert-butyldimethylsilyl ether [ prepared according to step (b) above]In addition, the title compound was obtained in 65% yield by operating in a similar manner to the procedures described in examples 76(c), 76(d) and 70(e) [ α]]_D ²⁴+19.41(c ═ 0.45, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.20-7.65(3H，multiplet)；

6.62(2H，singlet)；

0.75-4.90(12H，multiplet)；

3.87&3.89 (9H total, each unimodal);

2.86(3H, singlet). Infrared absorption spectrum v_maxcm^-1(KBr)：

2935, 1637, 1585. Mass Spectrometry (FAB) m/z: 562(M + H)⁺78(d)1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) hexahydro-1, 4-oxazepin-2-yl]Ethyl } spiro [ benzo [ c]]Thiophene-1 (3H), 4' -piperidines]- (2S) -oxides

Except using 2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) hexahydro-1, 4-oxazepin-2-yl]Ethanol methanesulfonate [ prepared as described in step (c) above]In addition, the title compound was obtained in 59% yield by operating in a similar manner to the procedure described in example 76(f) [ α]_D ²⁴+19.33(c ═ 0.1, methanol) HPLC analysis

Column: YMC-Pack ODS-A (250X 4.6 mm. RTM.)

Eluent:∶＝40∶60，0.1％

flow rate: 1.0ml/min

Retention time: 17.7min Nuclear magnetic resonance Spectroscopy (400MHz, CDCl)₃)δppm：

7.15-7.75(7H，multiplet)；

6.62(2H，broad singlet)；

0.75-4.80(29H，multiplet)；

4.29(1H，doublet，J＝17Hz)；

3.97(1H, doublet, J ═ 17 Hz); infrared absorption spectrum v_maxcm^-1(KBr)：

2928, 2855, 2836, 1637, 1584. Mass Spectrometry (FAB) m/z: 687(M + H)⁺

Example 791 methyl- {3- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl]morpholin-2-yl]propyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide (Compound No.3-42)79(a)4- (3, 4-dichlorophenyl) -4-oxobutanoate

8.50g (84.9mmole) of succinic anhydride and 24.8g (93.0mmole) of aluminum bromide are added successively to 150ml of 1, 2-dichlorobenzene, and the mixture is stirred at room temperature for 5 hours. At the end of stirring, the reaction mixture was poured into ice-cooled water and extracted with dichloromethane. The organic extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was dissolved in 100ml of methanol. To the resulting solution was added 1.0ml of sulfuric acid, and the mixture was heated under reflux for 4 hours. At the end of heating, the reaction mixture was cooled to room temperature, poured into water and extracted with ethyl acetate. The organic extract was washed successively with a saturated aqueous solution of sodium hydrogencarbonate and saturated aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate. Evaporating under reduced pressure to remove solvent, eluting with mixture of hexane and diethyl ether at volume ratio of 17: 3 to 7: 3, and purifying the residue by silica gel column chromatography to obtain 9.10g light orangeThe title compound was in the form of a colored crystal. Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

8.07(1H，doublet，J＝2Hz)；

7.81(1H，doublet of doublets，J＝2&8Hz)；

7.56(1H，doublet，J＝8Hz)；

3.71(3H，singlet)；

3.27(2H，triplet，J＝7Hz)；

2.78(2H, triplet, J ═ 7 Hz). Infrared absorption spectrum v_maxcm^-1(KBr)：

3093, 3061, 2954, 1746, 1678, 1583. Mass Spectrometry (EI) m/z: 260(M)⁺79(b) methyl 4- (3, 4-dichlorophenyl) -4-pentenoate

1.75g (49.0mmole) of methyltriphenyl bromide and 5.50g (49.0mmole) of potassium tert-butoxide are suspended in 200 g of anhydrous benzene, and the mixture is stirred at room temperature for 6 hours under a nitrogen atmosphere. At the end of the stirring, 8.50g of methyl 4- (3, 4-dichlorophenyl) -4-oxobutanoate [ prepared according to step (a) above]were added to the reaction mixture]Dissolved in 40ml of benzene. The mixture was stirred for 1 hour. The reaction mixture was then poured into water and extracted with ethyl acetate. The organic extract was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The residue was subjected to a silica gel column using a gradient elution method using a mixture of hexane and ethyl acetate at a volume ratio of 19: 1 to 23: 2 as an eluent, to give 4.20g of the title compound as a pale orange oil. Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.48(1H，doublet，J＝2Hz)；

7.40(1H，doublet，J＝8Hz)；

7.23(1H，doublet of doublets，J＝2&8Hz)；

5.32(1H，singlet)；

5.14(1H，singlet)；

3.67(3H，singlet)；

2.79(2H，triplet，J＝8Hz)；

2.48(2H, triplet, J ═ 8 Hz). Infrared absorption spectrum v_maxcm^-1(film)：

2952, 1740, 1630, 1550. Mass Spectrometry (EI) m/z: 258 (M)⁺)79(c)4- (3, 4-dichlorophenyl) -4-penten-1-ol tert-butyldimethylsilyl ether

Except that 4- (3, 4-dichlorophenyl) -4-pentenoate [ prepared by the above step (b)]Prepare for]In addition, the title compound was obtained in 93% yield by operating in a similar manner to the procedure described in example 1 (b). Nuclear magnetic resonance spectroscopy (400MHz, CDCl)₃)δppm：

7.49(1H，doublet，J＝2Hz)；

7.38(1H，doublet，J＝9Hz)；

7.24(1H，doublet of doublets，J＝2&9Hz)；

5.30(1H，singlet)；

5.13(1H，doublet，J＝1Hz)；

3.62(2H，triplet，J＝6Hz)；

2.52(2H，triplet，J＝8Hz)；

1.60-1.68(2H，multiplet)；

0.90(9H，singlet)；

0.04(6H, singlets). Infrared absorption spectrum v_maxcm^-1(film)：

2954, 2929, 2887, 2858, 1627, 1550. Mass Spectrometry (FAB) m/z: 345(M + H)⁺79(d) (2R) -5-tert-butyldimethylsilyloxy-2- (3, 4-dichlorophenyl) pentane-1, 2-diol

Except that 4- (3, 4-dichlorophenyl) -4-penten-1-ol tert-butylsilyl ether [ prepared as in step (c) above]is used]In addition, by operating in a similar manner to example 1(c), the title compound was obtained in 94% yield. Optical purity: 98% ee[α]_D ²⁴-2.08(c ═ 0.48, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.56(1H，doublet，J＝2Hz)；

7.41(1H，doublet，J＝8Hz)；

7.23(1H，doublet of doublets，J＝2&8Hz)；

4.96(1H，singlet)；

3.53-3.70(4H，multiplet)；

1.98-2.14(3H，multiplet)；

1.35-1.57(2H，multiplet)；

0.91(9H，singlet)；

0.082(3H，singlet)；

0.078(3H, singlet). Infrared absorption spectrum v_maxcm^-1()：

3584, 3311, 2956, 2932, 2861. Mass Spectrometry (FAB) m/z: 379 (M)⁺)79(e) (2R) -5- (tert-butyldimethylsilyloxy) -2- (3, 4-dichlorophenyl) -1- [ N- (tert-butoxycarbonyl) -N- (2-hydroxyethyl) amino]-2-pentanol

Except that (2R) -5-tert-butyldimethylsilyloxy-2- (3, 4-dichlorophenyl) pentane-1, 2-diol [ prepared as in step (d) above]is used]In addition, the title compound was obtained in 95% yield by operating in a similar manner to the procedure described in example 76(a) [ α]_D ²⁴-14.75(c ═ 0.61, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.15-7.65(3H，multiplet)；

5.30&5.79 (total 1H, each unimodal);

2.50-3.95(9H，multiplet)；

1.85-2.25(2H，multiplet)；

1.30-1.60(2H，multiplet)；

1.43(9H，singlet)；

0.89(9H，singlet)；

0.04&0.05 (total 6H, each singlet). Infrared absorption spectrum v_maxcm^-1(KBr)：

3355, 2955, 2931, 2894, 2858, 1668. Mass Spectrometry (FAB) m/z: 522(M + H)⁺79(f) (2R) -3- [ 4-tert-butoxycarbonyl-2- (3, 4-dichlorophenyl) morpholin-2-yl]-1-propanol tert-butyldimethylsilyl ether

Except that (2R) -5-, (Tert-butyldimethylsiloxy group]-2- (3, 4-dichlorophenyl) -1- [ N- (tert-butoxycarbonyl) -N- (2-hydroxyethyl) amino]-2-pentanol [ prepared according to step (e) above]In addition, the title compound was obtained in 92% yield by operating in a similar manner to that described in example 76(b) [ α]_D ²⁴+58.15(c ═ 0.54, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.40-7.65(3H，multiplet)；

4.14(1H，doublet，J＝14Hz)；

3.42-3.75(5H，multiplet)；

3.23(2H，doublet，J＝14Hz)；

1.15-2.00(4H，multiplet)；

1.44&1.52 (total 9H, each wide singlet);

0.85(9H，singlet)；

0.00&0.01 (total 6H, each singlet). Infrared absorption spectrum v_maxcm^-1()：

2957, 2931, 2860, 1668. Mass Spectrometry (FAB) m/z: 504(M + H)⁺79(g)3- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]-1-propanol

3.43g (6.80mmole) of (2R) -3- [ 4-tert-butoxycarbonyl-2- (3, 4-dichlorophenyl) morpholin-2-yl]-1-propanol tert-butyldimethylsilyl ether [ prepared according to step (f) above]Dissolved in 60ml of methylene chloride, and 2.98g (15.0mmole) of B-bromocatechol borane was added to the resulting solution. The mixture was stirred at room temperature for 2 hours under nitrogen atmosphere. At the end of the stirring, 60ml of water were poured into it, which was then stirred for a further 2 hours. The mixture was basified by the addition of 1N aqueous sodium hydroxide solution and then extracted with dichloromethane. The organic extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resulting residue was dissolved in 40ml of methylene chloride, and to the resulting solution were added 1.23ml (8.87mmole) of triethylamine, 1.65g (7.15mmole) of 3, 4, 5-trimethoxybenzoyl chloride and 10mg of 4-dimethylaminopyridine. The resulting mixture was stirred at room temperature 12 hours at the end of the stirring, the reaction mixturewas poured into water and extracted with dichloromethane, the organic extract was washed with saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure, the resulting residue was purified by column chromatography on silica gel using a mixture of dichloromethane and acetone in a volume ratio of 7: 3 as an eluent to give 2.13g of the title compound [ α]]_D ²⁴+30.78(c ═ 0.51, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

6.80-7.80(3H，multiplet)；

6.48(2H，broad singlet)；

3.30-4.80(8H，multiplet)；

3.84&3.86 (total 9H, each singlet);

1.10-2.35(4H, multiplex). Infrared absorption spectrum v_maxcm^-1(KBr)：

3426, 2942, 2872, 1632, 1584. Mass Spectrometry (FAB) m/z: 484(M + H)⁺79(h)3- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]-1-propanol methanesulfonate

Except using 3- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]-1-propanol [ prepared according to step (g) above)]In addition, the title compound was obtained in 84% yield by operating in a similar manner to the procedure described in example 70(e) [ α]_D ²⁴+27.87(c ═ 0.54, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

6.80-7.80(3H，multiplet)；

6.50(2H，singlet)；

3.20-4.50(8H，multiplet)；

3.85&3.86 (total 9H, each singlet);

2.97(3H，singlet)；

1.35-2.35(4H, multiplex). Infrared absorption spectrum v_maxcm^-1(KBr)：

3001, 2939, 2875, 2839, 1634, 1585. Mass Spectrometry (FAB) m/z: 562(M + H)⁺79(i)1{3- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Propyl } spiro [ benzo [ c]]Thiophene-1 (3H), 4' -piperidines]- (2S) -oxides

Except using 3- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]-1-propanol methanesulfonate [ prepared as in step (h) above]In addition, the title compound was obtained in 68% yield by operating in a similar manner to the procedure described in example 76(g) [ α]]_D ²⁴+26.97(c ═ 0.55, methanol) HPLC analysis

Column: YMC-Pack ODS-A (250X 4.6 mm. RTM.)

Eluent:∶＝40∶60，0.1％

flow rate: 1.0ml/min

Retention time: 23.4min Nuclear magnetic resonance Spectroscopy (400MHz, CDCl)₃)δppm：

6.80-7.80(7H，multiplet)；

6.48(2H，broad singlet)；

0.80-4.70(20H，multiplet)；

4.32(1H，doublet，J＝17Hz)；

4.00(1H，doublet，J＝17Hz)；

3.84&3.86 (9H in total, each singlet); infrared absorption spectrum v_maxcm^-1(KBr)：

2940, 2872, 2834, 2771, 1636, 1584. Mass Spectrometry (FAB) m/z: 687(M + H)⁺

EXAMPLE 801- {2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4-dimethoxybenzenesulfonyl l oxazolidin-5-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide (Compound No.3-2055)80(a)2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4-dimethoxybenzenesulfonyl) oxazolidin-5-yl]ethanol tert-butyldimethylsilyl ether

1.00g (2.72mmole) of 2- [ (5R) - (3, 4-dichlorophenyl) are added) Oxazolidin-5-yl]Ethanol tert-butyldimethylsilyl ether [ prepared as in example 1(f) first part]Dissolving in 10ml of pyridine, adding 773mg (3.27mmole) of 3, 4-dimethoxybenzenesulfonyl chloride to the resulting solution under ice-cooling, stirring the mixture under nitrogen for 2 hours, pouring the reaction mixture into 100ml of ice-cooled 10% w/v aqueous hydrochloric acid solution and extracting with ethyl acetate, washing the organic extract with saturated aqueous sodium chloride solution and then drying over anhydrous magnesium sulfate, evaporating the solvent under reduced pressure, eluting with a mixture of hexane and ethyl acetate in a volume ratio of 10: 1 to 2: 1, and purifying the resulting residue by silica gel column chromatography using a gradient elution method to obtain 1.27g of the title compound [ α]as a white crystal]_D ²⁴-5.74(c ═ 1.29, methanol) infrared absorption spectrum ν_maxcm^-1(KBr)：

1588, 1510, 1468, 1264, 1155, 1140. 80(b)2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4-dimethoxybenzenesulfonyl) oxazolidin-5-yl]ethanol methanesulfonate

1.19g (2.06mmole) of 2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4-dimethoxybenzenesulfonyl) oxazolidin-5-yl]Ethanol tert-butyl dimethylBasilyl ethers [ prepared according to step (a) above]Dissolved in 20ml of a 3: 1 by volume mixture of acetic acid, tetrahydrofuran and water and the mixture heated at 80 ℃ for 2 hours under nitrogen. At the end of the heating, the reaction mixture wasneutralized with a saturated aqueous solution of sodium hydrogencarbonate and extracted with ethyl acetate. The organic extract was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was dissolved in 10ml of pyridine. To the resulting solution, 23mg (0.19mmole) of 4-dimethylaminopyridine and 0.22ml (2.84mmole) of methanesulfonyl chloride were added under ice-cooling. The mixture was stirred at 0 ℃ for 2 hours under nitrogen atmosphere. At the end of the stirring, the reaction mixture was poured into 200ml of ice-cooled 10% w/v aqueous hydrochloric acid solution and extracted with ethyl acetate. The organic phase was washed with a saturated solution of sodium chloride and dried over anhydrous magnesium sulfate. Evaporating under reduced pressure to remove solvent, eluting with 2: 1 to 1: 2 volume ratio mixture of hexane and ethyl acetate, and purifying the residue by silica gel column chromatography to obtain 992mg of white crystalThe title compound [ α]]_D ²⁴-3.80(c ═ 0.5, methanol) nuclear magnetic resonance spectrum (400MHz, CDCl)₃)δppm：

7.33(1H，doublet，J＝8.6Hz)；

7.30(1H，doublet of doublets，J＝8.6&2.1Hz)；

7.14(1H，doublet，J＝2.2Hz)；

7.11(1H，doublet，J＝2.1Hz)；

6.92(1H，doublet of doublets，J＝8.7&2.2Hz)；

6.80(1H，doublet，J＝8.7Hz)；

5.08(1H，doublet，J＝5.7Hz)；

4.98(1H，doublet，J＝5.7Hz)；

4.11(1H，multiplet)；

3.94(3H，singlet)；

3.86(3H，singlet)；

3.82(1H，multiplet)；

3.70(2H, AB-quartet, J11.3 Hz, Δ δ 0.08 ppm);

2.88(3H，singlet)；

2.16(2H, multiplex). Mass Spectrometry (FAB) m/z: 540(M + H)⁺80(c)1- {2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4-dimethoxybenzenesulfonyl) oxazolidin-5-yl]Ethyl } spiro [ benzo [ c]]Thiophene-1 (3H), 4' -piperidines]- (2S) -oxides

105mg (0.19mmole) of 2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4-dimethoxybenzenesulfonyl) oxazolidin-5-yl group]Ethanol methanesulfonate [ prepared according to the above step (b)]]55mg (0.21mmole) of spiro [ benzo [ c]]Thiophene-1 (3H), 4' -piperidines]- (2S) -oxide hydrochloride (prepared as described in preparation 6), 49mg (0.58mmole) of sodium hydrogencarbonate, and 48mg (0.29mmole) of potassium iodide were suspended in 2ml of anhydrous dimethylformamide. The resulting mixture was heated at 80 ℃ for 8 hours under nitrogen atmosphere. At the end of the heating, the reaction mixture was poured into 10ml of saturated aqueous solution of sodium chloride and extracted with ethyl acetate. The organic extract was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. Dichloro in a volume ratio of 40: 1 to 20: 1The residue was purified by column chromatography on silica gel using a mixture of methane and methanol as eluent to give 82mg of the title compound as white crystals [ α]]_D ²⁴+2.5(c ═ 0.52, methanol) HPLC analysis

Column: YMC-Pack ODS-A (250X 4.6 mm. RTM.)

Eluent:∶＝40∶60，0.1％

flow rate: 1.0ml/min

Retention time: 21.4min infrared absorption spectrum v_maxcm^-1(KBr)：

1674, 1587, 1509, 1469, 1350, 1264, 1155, 1140, 1039. Mass Spectrometry (FAB) m/z: 665(M + H)⁺

Example 811- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl]morpholin-2-yl]ethyl } -1-methylspiro [ benzo [ c]thiophene-1 (3H), 4' -piperidinium]- (2S) -oxide iodide (methyl iodide salt of Compounds No.3-42)

300mg (0.45mmole) of 1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]Ethyl } spiro [ benzo [ c]]Thiophene-1 (3H), 4' -piperidines]- (2S) -oxide [ prepared as described in example 76]Dissolved in 3ml of acetonitrile, 30. mu.l (0.48mmole) of methyl iodide were added to the resulting solution, the mixture was stirred at room temperature overnight under nitrogen atmosphere, at the end of the stirring, the solvent was distilled off under reduced pressure, and the resulting residue was crystallized from diisopropyl ether to give 312mg of the title compound as pale yellow crystals [ α]]_D ²⁴+42.0(c ═ 1.0, methanol) HPLC analysis

Column: YMC-Pack ODS-A (250X 4.6 mm. RTM.)

Eluent:∶＝40∶60，0.1％

flow rate: 1.0ml/min

Retention time: 9.9min Infrared absorption Spectrum v_maxcm^-1(KBr)：

3444，1632，1584，1464，1126。Mass Spectrometry (FAB) m/z: 687 (free form, M)⁺) Elemental analysis:

calculated values:：

：51.54％；：5.07％；：3.44％；：3.93％；：8.69％；：15.56％。

actually measuring:：51.14％；：5.39％；：3.42％；：4.01％；：8.50％；：15.96％。

Claims (56)

1. a compound of formula (I) and its quaternary ammonium derivatives of formula (Ia):wherein R is¹And R²Which may be the same or different, each represents a carbocyclic aryl or an aromatic heterocyclic group, the aryl and heterocyclic groups being unsubstituted or substituted by at least one substituent preferably selected from the group consisting of α, A represents a methylene group, a carbonyl group or a sulfonyl group, B represents the groups A and R¹An alkylene group having 1 to 4 carbon atoms or an alkenylene group having 2 to 4 carbon atoms; d represents an oxygen or sulfur atom; e represents an alkylene group having 1 to 6 carbon atoms, a haloalkylene group having 1 to 6 carbon atoms, a cycloalkane-1, 1-diyl group having 3 to 6 carbon atoms, a cycloalkane-1, 1-diyl methyl group having 3 to 6 carbon atoms in the cycloalkane moiety or a cycloalkane-1, 1-di (C) group having 3 to 6 carbon atoms in the cycloalkane moietyAn oxymethyl group); g represents an alkylene group having 1 to 4 carbon atoms or an alkenylene group having 2 to 4 carbon atoms; l representsGroup or formulaGroup wherein R³Denotes a carbocyclic aryl or aromatic heterocyclic radical, which aryl and aromatic heterocyclic radicals are unsubstituted or substituted by at least one substituent preferably selected from the group of substituents α⁴Represents a hydrogen atom, a carbocyclic aryl or aromatic heterocyclic group which is unsubstituted or substituted by at least one substituent preferably selected from the group consisting of α⁵Expression formula (I)A group, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an amino group, an amido group, an amino group, anAn alkyl group having 1 to 6 carbon atoms and substituted with an amido group, an amido group having a nitrogen atom substituted with an alkyl group having 1 to 6 carbon atoms, a hydroxyl group, a hydroxyalkyl group having 1 to 6 carbon atoms, an alkoxyalkyl group having both an alkoxy moiety and an alkyl group each having 1 to 6 carbon atoms, or an aralkyloxyalkyl group wherein an oxyalkyl moiety has 1 to 6 carbon atoms, an alkyl moiety of an aralkyl moiety has 1 to 4 carbon atoms and is substituted with 1 to 3 carbocyclic aryl groups which are unsubstituted or substituted with at least one substituent preferably defined by α below,

wherein R is⁶Represents an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, formulaA group, a carbocyclic aryl or heterocyclic group, the aryl and heterocyclic groups being unsubstituted or substituted by at least one substituent preferably customized to the substituent α,

wherein R is^aRepresents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an aliphatic carboxylic acid group having 1 to 6 carbon atoms, an alkylsulfonyl group having 1 to 6 carbon atoms, an haloalkylsulfonyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, a carbocyclic aryl group which is unsubstituted or substituted by at least one substituent preferably defined as α below, or an aralkyl group in which the alkyl moiety has 1 to 4 carbon atoms and is substituted by 1 to 3 carbocyclic aryl groups defined as below, and

R^brepresents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an aliphatic carboxylic acid group having 1 to 6 carbon atoms, an alkylsulfonyl group having 1 to 6 carbon atoms, an haloalkylsulfonyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, a carbocyclic aryl group or an aromatic heterocyclic group which are unsubstituted or substituted by at least one substituent preferably defined as α below, or an aralkyl group in which the alkyl moiety has 1 to 4 carbon atoms and is substituted by 1 to 3 carbocyclic aryl groups as defined above, or

R^aAnd R^bTogether with the nitrogen atom to which they are attachedNitrogen-containing heterocyclic group, or R⁴And R⁵Together with the carbon atom to which they are attached represent a cycloalkyl group having 5 to 10 ring atoms, which is unsubstituted or substituted by at least one substituent selected from the group consisting of substituents β as defined below, and which has one heteroatom selected from nitrogen, oxygen and sulfur atoms, or R⁴And R⁵Together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclyl group as defined above and fused to a carbocyclic aryl or aromatic heterocyclyl group, which aryl or aromatic heterocyclyl group is unsubstituted or substituted by at least one substituent preferably defined as substituent α⁷Represents an alkyl group having 1 to 6 carbon atoms, and the above-mentioned substituent α is selected from the group consisting of a halogen atom, an alkyl group having 1 to 6 carbon atoms, a haloalkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an aliphatic carboxylic acid group having 1 to 6 carbon atoms, an alkylsulfonyl group having 1 to 6 carbon atoms, an haloalkylsulfonyl group having 1 to 6 carbon atoms, a hydroxyl group, a carboxyl group, an alkoxycarbonyl group having 1 to 6 carbon atoms in the alkoxy moiety, an acylamino group having 1 to 6 carbon atoms, an alkylsulfonylamino group having 1 to 6 carbon atoms, an haloalkylsulfonyl group having 1 to 6 atoms, an amino group, a cyano group, and an alkylene group having 1 to 8 carbonatoms (forming a cycloalkyl group fused with an aryl group or a heterocyclic group), the above-mentioned substituent β is:

when substituting carbon atoms, oxo

When a nitrogen atom is substituted, it is selected from the group consisting of an alkylsulfonyl group having 1 to 6 carbon atoms, an alkyl group having 1 to 6 carbon atoms which is unsubstituted or substituted with at least one substituent preferably self-defined as the substituent γ, an aliphatic acyl group, a carbocyclic aryl group which is unsubstituted or substituted with at least one substituent preferably self-defined as the substituent α above, an aralkyl group in which the alkyl moiety has 1 to 4 carbon atoms and is substituted with 1 to 3 carbocyclic aryl groups as defined above, and when a sulfur atom is substituted, one or two oxygen atoms to form a sulfoxide or sulfone group, and the above-mentioned substituent γ is selected from the group consisting of a halogen atom, an alkoxy group having 1 to 6 carbon atoms, an aliphatic carboxyacyl group having 1 to 6 carbon atoms, an alkylsulfonyl group having 1 to 6 carbon atoms, a haloalkylsulfonyl group having 1 to 6 carbon atoms, a hydroxyl group, a carboxyl group, an alkoxycarbonyl group having 1 to 6 carbon atoms in the alkoxy moiety, an aliphatic acylamino group having 1 to 6 carbon atoms, an amino group, and a cyano group.

2. A compound according to claim 1, wherein E represents methylene.

3. The compound of claim 2, wherein R¹And R²May be the same or different and each represents a carbocyclic aromatic groupAn aromatic heterocyclic group or a carbocyclic aryl group substituted with 1 to 3 substituents α.

4. The compound of claim 2, wherein R²Represents a carbocyclic aryl group or a carbocyclic aryl group substituted with 1 to 3 substituents α.

5. A compound according to claim 2, wherein a represents a carbonyl group.

6. A compound according to claim 2, wherein B represents a single bond.

7. A compound according to claim 2, wherein D represents an oxygen atom.

8. The compound of claim 2, wherein G is alkylene having 1 to 4 carbon atoms.

9. The compound of claim 2, wherein G is alkylene having 2 or 3 carbon atoms.

10. The compound of claim 2, wherein R³Represents an aromatic heterocyclic group or a carbocyclic aryl group substituted with 1 to 3 substituents α.

11. A compound according to claim 2 wherein L represents formula (la)A group.

12. The compound of claim 2, wherein R⁴Represents a carbocyclic aryl or aromatic heterocyclic radical。

13. The compound of claim 2, wherein R⁵Expression formula (I)Group, wherein R⁶Represents an alkyl group having 1 to 6 carbon atoms or formulaA group.

14. The compound of claim 2, wherein R⁵Represents amino, amido or hydroxyl.

15. The compound of claim 2, wherein R⁴To R⁵Together with the carbon atom to which they are attached represent a cycloalkyl group having 5 to 10 ring atoms, which is unsubstituted or substituted by at least one substituent β, or a heterocyclyl group having a single heteroatom selected from nitrogen, oxygen and sulfur atoms⁴And R⁵Together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclyl group as defined above fused to a carbocyclic aryl or aromatic heterocyclyl group, which aryl or aromatic heterocyclyl group is unsubstituted or substituted by at least one substituent preferably selected from substituent α.

16. The compound of claim 2, wherein:

R¹and R²The same or different each represents a carbocyclic aryl group, an aromatic heterocyclic group or a carbocyclic aryl group substituted with 1 to 3 substituents α;

a represents a carbonyl group;

b represents a single bond;

d represents an oxygen atom;

g represents an alkylene group having 1 to 4 carbon atoms;

l representsA group;

R⁴represents a carbocyclic aryl or aromatic heterocyclic group, and

R⁵expression formula (I)The radical(s) is (are),wherein R is⁶Represents an alkyl group having 1 to 6 carbon atoms or formulaA group.

17. The compound of claim 2, wherein:

R¹and R²The same or different, each represents a carbocyclic aryl group, an aromatic heterocyclic group or a carbocyclic aryl group substituted with 1 to 3 substituents α;

a represents a carbonyl group;

b represents a single bond;

d represents an oxygen atom;

g represents an alkylene group having 1 to 4 carbon atoms;

l representsA group; and

R⁴and R⁵Together with the carbon atom to which they are attached represent a cycloalkyl group having 5 to 10 ring atoms, which is unsubstituted or substituted by at least one substituent β, and which has a single heteroatom selected from nitrogen, oxygen and sulfur, or R⁴And R⁵Together with the carbon atom to which they are attached represent the above cycloalkyl or heterocyclyl group fused to a carbocyclic aryl or aromatic heterocyclyl group, which aryl and aromatic heterocyclyl group are unsubstituted or substituted by at least one substituent selected from the group consisting of substituents α.

18. A compound according to claim 1 wherein E represents formula (la)A group wherein n is an integer from 2 to 4.

19. The compound of claim 18, wherein R¹And R²The same or different, each represents a carbocyclic aryl group, an aromatic heterocyclic group or a carbocyclic aryl group substituted with 1 to 3 substituents α.

20. The compound of claim 18, wherein R²Represents a carbocyclic aryl group or a carbocyclic aryl group substituted with 1 to 3 substituents.

21. A compound according to claim 18, wherein a represents carbonyl.

22. A compound according to claim 18, wherein B represents a single bond.

23. A compound according to claim 18, wherein D represents an oxygen atom.

24. A compound according to claim 18, wherein G represents an alkylene group having from 1 to 4 carbon atoms.

25. A compound according to claim 18, wherein G represents an alkylene group having 2 or 3 carbon atoms.

26. The compound of claim 18, wherein R³Represents an aromatic heterocyclic group or a carbocyclic aryl group substituted with 1 to 3 substituents α.

27. A compound according to claim 18 wherein L represents formula (la)A group.

28. The compound of claim 18, wherein R⁴Represents a carbocyclic aryl or aromatic heterocyclic group.

29. The compound of claim 18, wherein R⁵Expression formula (I)Group, wherein R⁶Represents an alkyl group having1 to 6 carbon atoms or formulaA group.

30. The compound of claim 18, wherein R⁵Represents amino, amido or hydroxyl.

31. The compound of claim 18, wherein R⁴And R⁵Together with the carbon atom to which they are attached, represent a group having 5 to 10Cycloalkyl or heterocyclyl of a ring atom, which group is unsubstituted or substituted by at least one substituent β, so as to have a single heteroatom in the heterocyclyl selected from nitrogen, oxygen and sulphur, or R⁴And R³Together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclyl group as defined above fused to a carbocyclic aryl or aromatic heterocyclyl group, which aryl or aromatic heterocyclyl group is unsubstituted or substituted by at least one substituent preferably selected from substituent α.

32. The compound of claim 18, wherein n is 2 or 3.

33. The compound of claim 18, wherein n is 2.

34. The compound of claim 18, wherein:

R¹and R²The same or different, each represents a carbocyclic aryl group, an aromatic heterocyclic group or a carbocyclic aryl group substituted with 1 to 3 substituents α;

a represents a carbonyl group;

b represents a single bond;

d represents an oxygen atom;

g represents an alkylene group having 1 to 4 carbon atoms;

l represents a group of the formulaA group;

R⁴represents an aryl group or an aromatic heterocyclic group;

R⁵expression formula (I)Group, wherein R⁶Represents an alkyl group having 1 to 6 carbon atoms or formulaA group; and

n is 2 or 3.

35. The compound of claim 18, wherein:

R¹and R²The same or different, each represents a carbocyclic aryl group, an aromatic heterocyclic group or a carbocyclic aryl group substituted with 1 to 3 substituents α;

a represents a carbonyl group;

r represents a single bond;

d represents an oxygen atom;

g represents an alkylene group having 1 to 4 carbon atoms;

l represents a group of the formulaA group of (a);

R⁴and R⁵Together with the carbon atom to which they are attached represent a cycloalkyl group having 5 to 10 ring atoms, which is unsubstituted or substituted by at least one substituent β, and which has a single heteroatom selected from nitrogen, oxygen and sulfur, or R⁴And R⁵Together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclyl group as defined above fused to a carbocyclic aryl or aromatic heterocyclyl group, which aryl and aromatic heterocyclyl group are unsubstituted or substituted by at least one substituent preferably selected from the group consisting of substituent α,and

n is 2 or 3.

36. The compound of claim 1, wherein R⁴And R⁵Together with the carbon atom to which they are attached represent a group of the formula

J represents an alkylene group having 1 to 6 carbon atoms;

ar represents a carbocyclic aromatic group or aromatic heterocyclic group fused to a ring containing J and S, the aromatic group or aromatic heterocyclic group being unsubstituted or substituted with at least one substituent preferably defined as the above substituent α, and

is shown in whichThe sulfur atom is a sulfoxide group of S-configuration.

37. The compound of claim 36, wherein R¹Represents a carbocyclic aryl group, an aromatic heterocyclic group, or a carbocyclic aryl group substituted with 1 to 3 substituents α.

38. RightsThe compound of claim 36, wherein R¹Represents a carbocyclic aryl group or from 1 to 3 substituents α¹Substituted carbocyclic aryl, and substituent α¹Selected from alkyl groups having 1 to 6 carbon atoms, havingHaloalkyl of 1 to 6 carbon atoms, and alkoxy of 1 to 6 carbon atoms.

39. The compound of claim 36, wherein R²Represents a carbocyclic aryl group or a carbocyclic aryl group substituted with 1 to 3 substituents α.

40. The compound of claim 36, wherein R²Represents a carbocyclic aryl group or a carbocyclic aryl group substituted by 1 to 3 halogen atoms.

41. A compound according to claim 36, wherein a represents carbonyl.

42. A compound according to claim 36, wherein B represents a single bond.

43. A compound according to claim 36, wherein D represents an oxygen atom.

44. A compound according to claim 36, wherein E represents C_1-4Alkylene or containing C therein_3-6C of cycloalkane-1, 1-diyl group_3-8An alkylene group.

45. A compound according to claim 36, wherein E represents methylene, ethylene, dimethylmethylene, 1, 1-dimethylethylene, 2, 2-dimethylethylene, cyclopropane-1, 1-diyl, cyclobutane-1, 1-diyl, cyclopentane-1, 1-diyl, cyclohexane-1, 1-diyl, cyclopropane-1, 1-diyl methyl, cyclobutane-1, 1-diyl methyl, cyclopentane-1, 1-diyl methyl or cyclohexane-1, 1-diyl methyl.

46. A compound according to claim 36, wherein G represents C_1-4An alkylene group;

47. the process of claim 36A compound wherein G represents C_2-3An alkylene group.

48. A compound according to claim 36, wherein J represents C_1-4An alkylene group.

49. A compound according to claim 36, wherein J represents methylene or ethylene.

50. The compound of claim 36, wherein ring Ar represents an aryl group, an aryl group substituted with 1 to 3 substituents α, or an aromatic heterocyclic group.

51. The compound of claim 36, wherein ring Ar represents a carbocyclic aryl group or a carbocyclic aryl group substituted with 1 to 3 substituents α.

52. The compound of claim 36, wherein:

R¹represents aryl, aromatic heterocyclic group, or carbocyclic aryl substituted with 1 to 3 substituents α;

R²represents a carbocyclic aryl group or a carbocyclic aryl group substituted with 1 to 3 substituents α;

a represents a carbonyl group;

b represents a single bond;

d represents an oxygen atom;

e represents C_1-4Alkylene or containing C therein_3-6Of cycloalkane-1, 1-diyl groupsC_3-8An alkylene group;

g represents C_1-4An alkylene group;

j represents C_1-4An alkylene group; and

ring Ar represents a carbocyclic aryl group, a carbocyclic aryl group substituted with 1 to 3 substituents α, or an aromatic heterocyclic group.

53. The compound of claim 36, wherein:

R¹represents a carbocyclic aryl group or from 1 to 3 substituents α¹Substituted carbocyclic aryl, and substituent α¹Selected from alkyl groups having 1 to 6 carbon atoms, halogen having 1 to 6 carbon atomsAlkyl substituents, and alkoxy groups having 1 to 6 carbon atoms;

R²represents a carbocyclic aryl group or a carbocyclic aryl group substituted by 1 to 3 halogen atoms;

a represents a carbonyl group;

b represents a single bond;

d represents an oxygen atom;

e represents methylene, ethylene, dimethylmethylene, 1, 1-dimethylethylene, 2, 2-dimethylethylene, cyclopropane-1, 1-diyl, cyclobutane-1, 1-diyl, cyclopentane-1, 1-diyl, cyclohexane-1, 1-diyl, cyclopropane-1, 1-diyl methyl, cyclobutane-1, 1-diyl methyl, cyclopentane-1, 1-diyl methyl or cyclohexane-1, 1-diyl methyl;

g represents C_2-3An alkylene group;

j represents a methylene group or an ethylene group; and

ring Ar represents a carbocyclic aryl group or a carbocyclic aryl group substituted with 1 to 3 substituents α.

54. The following compound of claim 1;

1- {2- [5- (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4-phenylpiperidine-4-carboxamide;

1- {2- [5- (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide);

1- {2- [5- (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (2-pyridyl) piperidine-4-carboxamide;

1{2- [5- (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (3-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (4-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (4-chlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4-phenylpiperidine-4-carboxamide;

1- {2- [5- (4-chlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide);

1- {2- [5- (4-chlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (2-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (4-chlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (3-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (4-chlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl) -4- (4-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (4-fluorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4-phenylpiperidine-4-carboxamide;

1- {2- [5- (4-fluorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide);

1- {2- [5- (4-fluorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (2-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (4-fluorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (3-pyridyl) piperidine-4-carboxamide;

1- {2- [5- (4-fluorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } -4- (4-pyridyl) piperidine-4-carboxamide;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4-carboxamide;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide);

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4- (pyrrolidin-1-ylcarbonyl) piperidine;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-morpholinocarbonyl-4-phenylpiperidine;

1- {2- [2- (4-chlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4-carboxamide;

1- {2- [2- (4-chlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide);

1- {2- [2- (4-fluorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4-carboxamide;

1- {2- [2- (4-fluorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide);

1- {2- [2- (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4-carboxamide;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl]ethyl } -4-phenylpiperidine-4- (N, N-dimethylformamide);

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzofuran-1 (3H), 4' -piperidine];

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine];

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ isobenzo [ c]thiophene-1 (3H), 4' -piperidine]-2-oxide;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ isoquinoline-1 (2H), 4' -piperidin]-3(4H) -one;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl]ethyl } spiro [ isobenzofuran-1 (3H), 4' -piperidine];

1- {2- [2- (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine];

1- {2- [2- (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]-2-oxide;

1- {2- [2- (3, 4-dichlorophenyl) -4- (3-methoxybenzoyl) morpholin-2-yl]ethyl } spiro [ isoquinoline-1 (2H), 4' -piperidin]-3(4H) -one;

1- {2- [ (5R) - (3, 4-dichlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H) 4' -piperidine]- (2S) -oxide;

1- {2- [ (5R) - (4-chlorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (5R) - (4-fluorophenyl) -3- (3, 4, 5-trimethoxybenzoyl) oxazolidin-5-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (4-chlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (4-fluorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) hexahydro-1, 4-oxazepin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (4-chlorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) hexahydro-1, 4-oxazepin-2-yl]ethyl } spiro[ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (4-fluorophenyl) -4- (3, 4, 5-trimethoxybenzoyl) hexaoxy-1, 4-oxazepin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (3, 4-dichlorophenyl) -4- (3-isopropoxyphenylacetyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine 1- (2S) -oxide;

1- {2- [ (2R) - (4-chlorophenyl) -4- (3-isopropoxyphenylacetyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (4-fluorophenyl) -4- (3-isopropoxyphenylacetyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide;

1- {2- [ (2R) - (3, 4-dichlorophenyl) -5, 5-dimethyl-4- (3, 4, 5-trimethoxybenzoyl) morpholin-2-yl]ethyl } spiro [ benzo [ c]thiophene-1 (3H), 4' -piperidine]- (2S) -oxide; and salts and esters thereof.

55. A composition for the treatment or prophylaxis of central nervous system disorders, neurodegenerative disorders, respiratory disorders, inflammatory disorders, allergy, allergic disorders, ophthalmic disorders, dermatological disorders, drug addiction, physical disorders due to stress, sympatholytic dystrophy, dysthymia, unwanted immune responses, disorders associated with increased immunity, digestive disorders, emesis, bladder dysfunction, eosinophilia, disorders due to abnormal blood flow, and pain, which comprises an active compound of formula (I) or (Ia), or a pharmaceutically acceptable salt or ester thereof, in admixture with a pharmaceutically acceptable carrier or diluent.

56. Use of a compound of formula (I) or (Ia) as defined in any one of claims 1 to 54, or a pharmaceutically acceptable salt or ester thereof, for the manufacture of a medicament for the treatment or prophylaxis of: central nervous system diseases, neurodegenerative diseases, respiratory diseases, inflammatory diseases, allergies, allergic diseases, ophthalmic diseases, skin diseases, drug addiction, physical diseases caused by stress, sympathoreflex dystrophy, dysthymia, undesired immune reactions, diseases associated with intensified immunity, digestive system diseases, emesis, bladder functional diseases, eosinophilia, diseases caused by abnormal blood flow, and pain.