HK1085393A - Remedies or preventives for allergic diseases comprising processed peanut seed coat - Google Patents

Description

Substance for treating or preventing allergic diseases comprising treated peanut seed coat product

Technical Field

The present invention relates to a substance for treating or preventing allergic diseases, which contains an active ingredient derived from peanut seed coats.

Background

Pollinosis exhibits symptoms such as sneezing or a continuous nasal discharge due to the inhalation of pollen, and the cause thereof is not completely understood. Since pollinosis often occurs in urban areas, the hypothesis that pollinosis involves dust or metal debris or reduction of parasites is a helpful factor. As far as the pathogenesis is concerned, pollinosis is an allergic reaction, and the onset of pollinosis is explained by the release of inflammatory substances caused by the binding of antigens and IgE to mast cells (columnar cells) in the form of bridges. Currently, as a medical method for treating pollinosis, administration of an antihistamine substance, oral immunological tolerance method, and the like are medically employed, but these methods are not decisive. Methods such as using a mask or a pollen inhalation prevention device are generally used, but these methods are not very effective.

For the treatment of allergic diseases such as pollinosis, allergic rhinitis, atopic dermatitis or bronchial asthma, steroid substances are widely used, but short-term use of such substances is desired due to the problem of side effects. However, in the case of discontinuing the use of steroids, it worsens the symptoms, and, in some cases, a condition known as a rebound phenomenon may occur in which the symptoms become worse than before the use of the steroids.

A treated peanut seed coat product is known to have myeloproliferative activity, anti-HIV activity, etc. (Japanese patent application Nos. JP-A-10-120588 and 11-246431, but there is no report on antiallergic activity.

Disclosure of the invention

The purpose of the present invention is to provide a substance that is effective for the treatment or prevention of allergic diseases.

That is, the present invention includes the following inventions.

(1) A substance for treating or preventing allergic disease, comprising a treated peanut seed coat product as an active ingredient.

(2) The substance for the treatment or prevention of allergic diseases as described in (1) above, wherein the treated peanut seed coat product is an extract obtained from peanut seed coats or a treated product thereof.

(3) The substance for the treatment or prevention of allergic diseases as described in the above (2), wherein the extract from peanut seed coat is an aqueous extract.

(4) A substance for treating or preventing allergic diseases, which comprises a water-soluble substance derived from peanut seed coats as an active ingredient.

(5) A substance for treating or preventing allergic diseases, which comprises a lower alcohol-soluble substance derived from peanut seed coats as an active ingredient.

(6) A substance for treating or preventing allergic diseases, which comprises water and a lower alcohol-soluble substance obtained from peanut seed coats as an active ingredient.

(7) The substance for treating or preventing allergic diseases as described in any one of (1) to (6) above, which is used for addition to foods, chewing gums or drinks.

(8) The substance for use in the treatment or prevention of an allergic disease as described in any of (1) to (7) above, wherein the allergic disease is pollinosis, allergic rhinitis, atopic dermatitis or bronchial asthma.

(9) A method for treating or preventing an allergic disease, comprising administering to a subject a pharmaceutical composition, a food, a chewing gum, or a beverage comprising a treated peanut seed coat product.

The peanut fruit has a hard pericarp and there are typically two seeds within the pericarp. The seeds are covered by seed coats. In the present invention, these seed coats are used.

In the present invention, the peanut seed coat may be applied in the form of a powdery product obtained by crushing, pulverizing or the like, but is preferably applied in the form of an extract or a treated product thereof.

Examples of the extraction solvent include water; lower alcohols such as methanol, ethanol, propanol, isopropanol, butanol and isobutanol; ethers such as diethyl ether and dioxane; ketones such as acetone, but water, ethanol or a mixed solvent of water and ethanol is preferred.

In extraction, the peanut seed coat may be applied untreated, or it may be crushed or powdered to allow more complete contact with the solvent.

The waste water obtained during washing with water to separate the peanut seed coat from the peanut seed is then purified or dried, if necessary as an extract, but preferably 1kg of peanut seed coat is extracted with 5 to 25L of solvent.

The extraction temperature is not particularly limited, but is usually from room temperature to the boiling point of the solvent under normal pressure. The extraction period depends on the extraction temperature and the like, but is preferably one day.

The extract thus obtained can be directly used as an active ingredient of the substance for treating or preventing allergic diseases of the present invention. Alternatively, the extract may be used in the form of a treated product having higher activity after being treated with various purification means such as ion exchange chromatography, gel filtration chromatography and dialysis. In this case, the purification is preferably carried out by exploiting the chemical nature of the active ingredient. That is, the preferable active ingredient of the substance for treating or preventing allergic diseases of the present invention has a property of being dissolved in water and/or lower alcohol (e.g., ethanol), and thus, by utilizing this property, an active ingredient having higher purity can be obtained by collecting a substance having water solubility, a substance having lower alcohol solubility, or a substance dissolved in water and lower alcohol.

The material for treating or preventing allergic diseases according to the present invention can be prepared into a pharmaceutical preparation by using the treated peanut seed coat product and a known pharmaceutical carrier. The dosage form is not particularly limited and may be suitably selected, but the substance of the present invention is generally used in the form of an oral preparation such as a tablet, capsule, granule, fine granule, powder, solution, syrup, suspension, emulsion or elixir, or a parenteral preparation such as an injection, drop, suppository, inhalant, transdermal absorbent, transmucosal absorbent or poultice (poultice).

The dose of the substance for treating or preventing allergic diseases of the present invention may vary depending on the age, body weight, degree of disease, or administration route of a patient. In oral administration, the dose of the substance as a dry powder of peanut seed coat extract is usually 50 to 1,000mg per day, and the frequency of administration in oral administration is one to three times a day.

Such oral formulations may be prepared by conventional methods using excipients such as starch, lactose, sucrose, mannitol, carboxymethylcellulose, corn starch or inorganic salts.

In such formulations, binders, disintegrants, surfactants, lubricants, glidants, flavoring agents, colorants, flavors, and the like may be suitably used in addition to the above-mentioned excipients.

Examples of the binder may include crystalline cellulose, crystalline cellulose/sodium carboxymethylcellulose, methylcellulose, hydroxypropylcellulose having a low degree of substitution, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, sodium carboxymethylcellulose, ethylcellulose, carboxymethylethylcellulose, hydroxyethylcellulose, wheat starch, rice starch, corn starch, potato starch, dextrin, gelatinized starch, partially gelatinized starch, hydroxypropyl starch, pullulan, polyvinylpyrrolidone, aminoalkyl methacrylate copolymer E, aminoalkyl methacrylate copolymer RS, methacrylate copolymer L, methacrylate copolymer S, methacrylate copolymer LD, polyvinyl acetal diethylaminoacetate (polyvinyl acetate) copolymer, Polyvinyl alcohol, acacia, powdered acacia, agar, gelatin, shellac, tragacanth, refined sucrose, polyethylene glycol 200, polyethylene glycol 300 and polyethylene glycol 6000.

Examples of the disintegrant may include crystalline cellulose, methylcellulose, hydroxypropyl cellulose having a low degree of substitution, carboxymethylcellulose calcium (carmelosacarcicum), carboxymethylcellulose sodium, croscarmellose sodium, wheat starch, rice starch, corn starch, potato starch, partially gelatinized starch, hydroxypropyl starch, sodium carboxymethyl starch, and tragacanth gum.

Examples of the surfactant may include soybean lecithin, sucrose fatty acid ester, polyoxyl stearate 40(polyoxyl stearate-40), polyoxyethylene hardened castor oil 100, polyoxyethylene hardened castor oil 40, polyoxyethylene hardened castor oil 50, polyoxyethylene hardened castor oil 60, polyoxyethylene [42] polyoxypropylene [67] diol, polyoxyethylene [54] polyoxypropylene [39] diol, polyoxyethylene [105] polyoxypropylene [5] diol, polyoxyethylene [160] polyoxypropylene [80] diol, polyoxyethylene [196] polyoxypropylene [67] diol, sorbitan sesquioleate, sorbitan trioleate, sorbitan monostearate, sorbitan monopalmitate, sorbitan monolaurate, polysorbate 40, polysorbate 60, polysorbate 65, polysorbate 80, glycerol monostearate, polyoxyethylene sorbitan monolaurate 40, polysorbate 60, polysorbate 65, polysorbate 80, glycerol monostearate, Sodium lauryl sulfate and lauromacrogol.

Examples of the lubricant may include wheat starch, rice starch, corn starch, stearic acid, calcium stearate, magnesium stearate, hydrated silicon dioxide, light anhydrous silicic acid, synthetic aluminum silicate, dry aluminum hydroxide gel, talc, magnesium aluminum silicate (magnesium aluminate silicate), calcium hydrogen phosphate, anhydrous calcium hydrogen phosphate, sucrose fatty acid ester, waxes, hydrogenated vegetable oil, and polyethylene glycol.

Examples of glidants may include hydrous silicon dioxide, light anhydrous silicic acid, dry aluminum hydroxide gel, synthetic aluminum silicate and magnesium silicate.

In the case where the substance for treating or preventing allergic diseases of the present invention is administered in the form of a solution, syrup, suspension, emulsion or elixir, it may contain a flavoring agent or a coloring agent.

The substance for treating or preventing allergic diseases according to the present invention can be added to foods, chewing gums, beverages, etc. to prepare a so-called specific supplementary food.

The inventive substance for treating or preventing allergic diseases can be used for treating or preventing various allergic diseases such as pollinosis, allergic rhinitis, atopic dermatitis, and bronchial asthma.

The peanut seed coat is a raw material for producing the material for treating or preventing allergic diseases of the present invention, which is used as food together with peanut seeds, so that the safety of the material has been determined.

Brief Description of Drawings

FIG. 1 is a graph showing the nuclear magnetic resonance spectrum of an extract derived from peanut seed coat.

This specification includes the disclosure disclosed in the specification of Japanese patent application No. 2001-263795, which is a priority document of this specification.

Best Mode for Carrying Out The Invention

The invention is further described in the following examples. However, these examples are not intended to limit the scope of the present invention.

(example 1)

(1) Preparation of extract from peanut seed coat

Seeds of peanuts (groundnut, leguminous) produced in China are dried for about one month, and then their seed coats are separated. Twenty-five grams of dried seed coats were accurately weighed and placed in a 2 liter Erlenmeyer flask. One liter of purified water was added thereto and left at room temperature (22. + -. 3 ℃ C.) for 24 hours. The resulting mixture was filtered with a filter cotton, and the filtrate was freeze-dried to obtain a peanut seed coat extract powder (yield: 4.4484g per 25g of peanut seed coat). The powder is a hygroscopic reddish-brown fine powder which is odorless and bitter. This powder is readily soluble in both water and ethanol.

FIG. 1 shows NMR spectra of peanut seed coat extract. From the nmr spectrum, it is predicted that the main component of peanut seed coat extract is polyphenol.

(2) Human clinical data obtained using peanut seed coat extract

The powder of peanut seed coat extract obtained in the above-mentioned (1) is dissolved in mineral water, and the resulting solution is orally administered to patients with allergic diseases, and then the progress thereof is observed.

(case A)

Patients with pollinosis for 20 years. The patient is blocked and can only breathe through the mouth during months from mid february to the end of the May continuous holiday each year. The patient also suffered from severe ocular itching and severe ocular congestion. The patient has been suffering from various symptoms such as itching even in the ear.

Starting from about 2/14/2001, when symptoms of pollinosis appear, 500mg of peanut seed coat extract powder is dissolved in 1,500ml of mineral water, and then the patient starts to take the peanut seed coat extract powder at a rate of 500mg for 3 days. On the first day, there was no significant change, but after 2 or 3 days, symptoms were greatly reduced, and after 1 week, symptoms such as nasal congestion or itching of the eyes almost disappeared. Some symptoms continue to appear for several days when getting up in the morning, but they disappear after a short time of taking the peanut seed coat extract powder solution.

In the case where the patient does not use the peanut seed coat extract powder solution for about half a day, nasal congestion or itching of the eyes may occur again. However, after taking the solution, such symptoms are alleviated. Initially, it is effective to administer a small amount (about 100ml) of this solution every 2 or 3 hours.

After about 1 month, although the dose was slightly reduced, the symptoms did not appear. In addition, the schedule of administration of the extract powder was also reduced to once in the morning, noon and evening (100 mg peanut seed coat extract powder per day), but symptoms did not appear.

(case B)

Patients suffer from itching and runny eyes from pollinosis from the beginning of two months to the end of four months in about 10 years. Patients are administered with injections for the treatment of pollinosis when symptoms are severe, but patients stop administration of injections 3 years ago due to consideration of side effects.

From 2 months and 22 days 2001, 500mg of peanut seed coat extract powder was dissolved in 1,500ml of mineral water, and the patient began to take the peanut seed coat extract powder on a schedule of 500mg for 3 days.

On day one, the patient did not feel any special effect, but the itching of the eyes was reduced on day 2, and almost no itching was felt on day 3. The patient continued to sneeze when getting up in the morning before administration of the peanut seed coat extract powder solution. However, both sneezing and nasal discharge stopped after administration. The administration of the peanut seed coat extract powder solution is stopped after about half a month, but symptoms of pollinosis do not appear.

(case C)

Approximately from the spring of 1984, patients had significant symptoms of hay fever (itching eyes and nasal congestion). However, because pollinosis has not been recognized at that time, patients have been diagnosed with allergic rhinitis. Approximately in 1990, with the recognition of pollinosis, patients were diagnosed with severe pollinosis. The patient is treated with medication for symptoms such as itching of the eyes and nasal congestion. Due to the "drowsy" side effect, patients have difficulty concentrating on work and have been through painful lives.

In month 2 of 2001, patients went to the hospital once a week and were dependent on treatment with drugs for some years ago, because they had significant symptoms of hay fever.

Starting from 3/16 in 2001, the patients began to use a bottled peanut seed coat extract powder solution obtained by dissolving 500mg of peanut seed coat extract powder in 1,500ml of mineral water, at the dosage shown in fig. 1.

TABLE 1

Date	Dosage (bottle)	Status of state
			3/16/2001	1	Symptoms such as severe ocular itching and nasal congestion due to discontinuation of drug administration
3 month and 17 days 2001	1	Suffering the same severe symptoms as the previous day
			3/18/2001	1	The itching of eyes is slightly relieved
3/19/2001	0.5	Although the degree is subtle, the symptoms are gradually relieved
			3/20/2001	0.5	Same as above
3/21/2001	0.5	Same as above
			3 month and 22 days 2001	0.5	Same as above
3/23/2001	0.5	Same as above
			24 days 3 month in 2001	0.5	Same as above
3/25/2001	0.5	Same as above
			3/26/2001	0.5	Same as above
3 month and 27 days 2001	1	There was a marked sign of improvement. The state of the nose was improved in the afternoon and the taste was restored.
			3 month and 28 days 2001	1	The state of the nose and throat is further improved.
3 month 29 year 2001	1
			3 month and 30 days 2001	1
3/31/2001	1	The symptoms of pollinosis disappear almost completely.
			4 month and 1 day of 2001	1
4.4.2.2001	1
			4 month and 3 days in 2001	1	Although pollen levels were high, the patient had only slight eye itching and was less painful.
2001 year, 4 months and 4 days	1	Same as above
			4/month/5/2001	1	Although pollen levels were high, the patient was normal.
4/6/2001	1
			4/7/2001	1

As described above, since severe symptoms of pollinosis are alleviated without side effects, the patient can maintain the willingness to work.

(case D)

In month 2 of this year (2001), the patient was suddenly affected by pollinosis. First, the patient is runny and has no symptoms such as sneezing or itchy eyes. Over time, symptoms such as sneezing, itchy eyes, and pain due to a runny nose occur as if water were entering the nose. Patients of this type have inflammation and pain under the nose because they blow their nose all day. Thus, the patient is treated for rhinitis with a commercially available drug. Rhinitis is thus relieved, but the patient suffers from severe symptoms such as nausea, dry mouth, drowsiness, etc. Thus, the patient stops using the drug.

The patient then begins to use the peanut seed coat extract powder.

First, 500mg of peanut seed coat extract powder was dissolved in 1,500ml of mineral water, and then about 50ml of peanut seed coat extract powder solution was administered to a patient. After a period of time, the nasal discharge ceases, and then the pain, sneezing and eye itching disappear as if water had entered the nose. Nausea, dry mouth and drowsiness, which occur when patients use commercially available drugs, do not occur at all. Since symptoms of pollinosis appear after about 3 hours, the patient repeatedly takes the same amount of peanut seed coat extract solution. After a period of time, the duration of the extract solution is extended from 3 hours to 4 hours, then to 5 hours, and finally, the symptoms of pollinosis can be eliminated by administering only in the morning.

(case E)

A47 year old male

On day 8/3 of 2001, the male patients developed pustules on the hands and feet due to chronic atopic dermatitis. The patient is orally administered an antihistamine and vitamin formulation, and also a steroid ointment.

Symptoms become quite apparent starting approximately at 5 months 2001. Thus, the patient is occasionally injected intravenously with steroids, the symptoms are thus temporarily improved and the patient appears to be recovering. However, symptoms reappear and become worse than before.

In 7 months of 2001, 500mg of peanut seed coat extract powder was dissolved in 1,500ml of mineral water to prepare an aqueous solution, and then 500ml of the solution was administered to the patient daily in three divided portions. Thereafter, the patient stopped the steroid injection while using the aqueous solution obtained from the peanut seed coat extract powder every day. The symptoms are thereby improved.

Data of 5 months in 2001

IgE 740IU/ml

Eosinophil 20% leucocyte image

Neutrophil leucocyte 40% leucocyte image

Data of 9 months in 2001

IgE 520IU/ml

Eosinophil 15%

Neutrophil leucocyte 43%

(case F)

A 25 year old female

From its 15 years of age, this female patient suffers from diffuse atopic dermatitis. It has been treated with Chinese herbal medicines and Chinese ointment, but because the symptoms begin to worsen from about 11 months in 2000, she is even unable to work, and is very depressed. Therefore, she also had occasional intravenous injections of steroids, and she also applied steroid ointments.

Symptoms temporarily improved, but then recurred. Thus, patients stopped the administration of steroids in month 4 of 2001. 500mg of peanut seed coat extract powder was dissolved in 1,500ml of mineral water to prepare an aqueous solution, and then the patient started to use 500ml of the solution every day for three times.

Approximately 11 months in 2001, the symptoms subsided and she had no more repeat appearance of the disease.

Data of 4 months in 2001

IgE 950IU/ml

Eosinophil 36%

Neutrophil leucocyte 43%

Lymphocyte 15%

Data of 8 months in 2001

IgE 430IU/ml

Eosinophil 25%

Neutrophil leucocyte 45%

20% of lymphocytes

(case G)

A 57 year old female

This woman has been suffering from pollinosis for a long time and she also developed atopic dermatitis in 7 months in 2000. She had a good treatment progress with the steroid-free ointment.

In 4 months 2001, patients used steroid ointments and started to take steroid drugs orally, because atopic dermatitis and pollinosis were both worsening. The symptoms are thereby alleviated. However, at about 9 months, the symptoms become worse than before, so the patient stops using the steroid ointment and the steroid drug. An aqueous solution was prepared by dissolving 500mg of peanut seed coat extract powder in 1,500ml of mineral water, and then the patient started to use 500ml of the solution every day for three times. Then, the symptoms disappeared.

Data from 2001

IgE 650IU/ml

Strong positive for house dust and mite

11 month data of 2001

IgE 500IU/ml

White blood cells were normal.

(case H)

A 58 year old female

The patient has been treated for a long time for bronchial asthma and atopic dermatitis. She was treated with bronchodilators, antitussives and inhalants.

In 2001, skin symptoms worsened, so patients were administered steroids.

Symptoms disappeared temporarily, but since atopic dermatitis and asthma attacks became severe in 9 months of 2001, patients were discontinued from all the medications used. 500mg of peanut seed coat extract powder was dissolved in 1,500ml of mineral water to prepare an aqueous solution, and then the patient started to use 500ml of the solution every day for three times. The symptoms of atopic dermatitis and asthma were all alleviated. The patients were in good condition to date.

Data of 1 month in 2001

IgE 450IU/mL

Data of 10 months in 2001

IgE 400IU/ml

(case I)

A 21 year old female

The patient had bronchial asthma from about the age of 9. Symptoms worsen approximately 4 years ago. Its onset is severe and is hospitalized 4 or 5 times a year. The dosage of the drug is increasing year by year, so she is heavily afflicted with the side effects of the drugs used, such as trembling hands, palpitations, insomnia and dysfunctional uterine bleeding.

Prednine (5mg) tablets (adrenocortical hormone):

one tablet is taken in the morning and another tablet is taken in the evening for 12 years.

Diclofenac tablet (bronchodilator):

one tablet is taken in the morning and another tablet is taken in the evening for 12 years.

Theodur (200mg) tablets (bronchodilators):

one tablet is taken in the morning and another tablet is taken in the evening for 12 years.

Ambroxol tablet (expectorant):

one tablet was taken in the morning, noon and evening for 10 years.

One bottle (13.5ml) of albuterol inhalant (bronchodilator) was administered for 12 years.

One vial of beclomethasone dipropionate 100D (steroid inhalant) was administered for 12 years.

Singulair 10 (asthma preventative) was administered in the evening for approximately 10 years.

One cramit tablet (macrolide antibiotic; only used when bronchitis occurs) was taken in the morning, noon and evening 1 to 3 times a day for 4 years.

In 9 months 2001, the patient had severe attacks, suffered from hand trembling, palpitations, and insomnia as side effects of the drugs used, and in particular, the patient had 2 months of continuous dysfunctional uterine bleeding.

The patient discontinued all medications. Then, 500mg of the peanut seed coat extract powder was dissolved in 1,500ml of mineral water to prepare a solution, and then the patient started to use 500ml of the solution every day for three times. The patient's asthma was relieved from the first day and after 3 days dysfunctional bleeding ceased. In addition, allergic rhinitis disappeared and no asthma symptoms appeared until 1 month in 2002. Even if the patient had a cold, symptoms did not appear.

Steroids (external application, oral administration, intravenous injection, and inhalation) are widely used for the treatment of atopic dermatitis (particularly adult type), bronchial asthma, allergic rhinitis, etc., and antihistamines are used together. There is no special provision for the application, but it is only certain that it is used until the symptoms disappear. For this reason, long-term application of the substance is often observed at present. It is particularly desirable to use topical steroid substances in descending order and eventually replace the substance with a topical non-steroidal substance. For steroid substances for oral administration, intravenous injection or inhalation, it is desirable to use these substances for a short period of time, but since the symptoms are difficult to relieve, they are often required to be used for a long period of time.

In such cases, the use of the product of treated peanut coats makes it possible to carry out the treatment of allergic diseases without the occurrence of rebound phenomena, even if the administration of the steroid substance is stopped.

(example 2)

After 1,100mg of peanut seed coats were soaked in 100ml of boiled water at 85 ℃ for 1.5 minutes, the extracted reddish-blood solution was filtered, and the filtrate was filled into a bottle. This bottle was heated at 110 ℃ for 10 minutes to degas the air contained in the solution. After degassing, the bottle was capped with a stainless steel crown cap and then sealed with the cap. The bottle sealed with a cap containing the solution was soaked in boiling water at 90 ℃ for 2 hours to be sterilized. By this heating process, the solution in the bottle became a clear red-blood beverage.

(example 3)

1,500mg of peanut seed coat and 500ml of water were put into a pottery bottle, which was then boiled with a gray fire for 30 minutes to reduce the mixture to half amount. The resulting blood red solution was filtered and the resulting extract was determined to be administered to a human daily.

(example 4)

An amount of peanut seed coat was placed in 99.9% ethanol at 18 ℃ so that the amount deposited was 30% alcohol by volume, and was left for 40 days. Freeze drying the obtained extract to obtain powder.

The powder thus obtained is directly used as an active ingredient of the substance for treating or preventing allergic diseases of the present invention.

(example 5)

10g of the powder from example 4 was mixed with 490g of corn starch, and water was further added thereto, followed by kneading. Thereafter, the mixture was granulated with a sieve having a mesh of 1mm × 1mm and dried to obtain granules.

1g of granules comprises 20mg of the powder obtained in example 4. According to the symptoms, 5 to 10g of each granule is administered three times a day.

All publications, patents, and patent applications cited herein are incorporated by reference in their entirety.

Industrial applicability

The present invention provides a substance effective for treating or preventing various allergic diseases such as pollinosis, allergic rhinitis, atopic dermatitis and bronchial asthma.

Claims (9)

1. A substance for treating or preventing allergic disease, comprising a treated peanut seed coat product as an active ingredient.

2. The substance for treating or preventing allergic diseases according to claim 1, wherein the treated peanut seed coat product is an extract from peanut seed coat or a treated product thereof.

3. The substance for treating or preventing allergic diseases according to claim 2, wherein the extract from peanut seed coat is an aqueous extract.

4. A substance for treating or preventing allergic diseases, which comprises a water-soluble substance derived from peanut seed coats as an active ingredient.

5. A substance for treating or preventing allergic diseases, which comprises a lower alcohol-soluble substance derived from peanut seed coats as an active ingredient.

6. A substance for treating or preventing allergic diseases, which comprises water and a lower alcohol-soluble substance obtained from peanut seed coats as an active ingredient.

7. The substance for treating or preventing allergic diseases according to any one of claims 1 to 6, which is used for addition to foods, chewing gums or beverages.

8. The substance for use in the treatment or prevention of allergic diseases according to any of claims 1 to 7, wherein the allergic diseases are pollinosis, allergic rhinitis, atopic dermatitis or bronchial asthma.

9. A method for treating or preventing an allergic disease, comprising administering to a subject a pharmaceutical composition, food, chewing gum, or beverage comprising a treated peanut seed coat product.