HK1070372A1 - Immunological adjuvant compounds - Google Patents
Immunological adjuvant compounds Download PDFInfo
- Publication number
- HK1070372A1 HK1070372A1 HK05100598.1A HK05100598A HK1070372A1 HK 1070372 A1 HK1070372 A1 HK 1070372A1 HK 05100598 A HK05100598 A HK 05100598A HK 1070372 A1 HK1070372 A1 HK 1070372A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- added
- mixture
- solution
- methylene chloride
- minutes
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (9)
- Verbindung der Formel (I): wobei :R1 ausgewählt ist aus der Gruppe bestehend aus -C(O)-, -C(O) (CH2)2-C(O)- und -C(O) (CH2)4-C(O)-.
- Verbindung nach Anspruch 1, wobei R1 -C(O)- ist.
- Verbindung der Formel (II) wobei:R1 ausgewählt ist aus der Gruppe bestehend aus -C(O)- und -C(O) (CH2)2-C(O)-.
- Verbindung der Formel: oder
- Verbindung der Formel (V): wobei:R1 ausgewählt ist aus der Gruppe bestehend aus -C(O)-, -C(O) (CH2)-C(O)-, -C(O)(CH2)2-C(O)-, -C(O)(CH2)4-C(O)-, -C(O)(CH2)6-C(O)-, -C(O)(CH2)8-C(O)- und -C(O)(CH(R2))-C(O)-;R2ist;R3 ausgewählt ist aus der Gruppe bestehend aus -H und -(CH2)2NHBoc.
- Verbindung nach Anspruch 5 mit der Formel:
- Verbindung der Formel (VI): wobei:R1 ausgewählt ist aus der Gruppe bestehend aus -C(O)-, -C(O) (CH2)-C(O)- und -C(O) (CH(R2))-C(O)-;R2 ausgewählt ist aus der Gruppe bestehend aus (CH2)4NHBoc undR3 ausgewählt ist aus der Gruppe bestehend aus -(CH2)2NHBoc, -(CH2)2NH2, -(CH2)2NH(CO)(CH2)4C(O)OH.
- Verbindung der Formel (VI): wobei:R1 ist.
- Verbindung mit der Formel oder
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11813199P | 1999-02-01 | 1999-02-01 | |
| US118131P | 1999-02-01 | ||
| HK02102786.2A HK1043132B (en) | 1999-02-01 | 2000-02-01 | Immunological adjuvant compounds |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK02102786.2A Addition HK1043132B (en) | 1999-02-01 | 2000-02-01 | Immunological adjuvant compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK02102786.2A Division HK1043132B (en) | 1999-02-01 | 2000-02-01 | Immunological adjuvant compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HK1070372A1 true HK1070372A1 (en) | 2005-06-17 |
| HK1070372B HK1070372B (en) | 2011-04-01 |
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