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GT201400285A - Formulacion de anticuerpos - Google Patents

Formulacion de anticuerpos

Info

Publication number
GT201400285A
GT201400285A GT201400285A GT201400285A GT201400285A GT 201400285 A GT201400285 A GT 201400285A GT 201400285 A GT201400285 A GT 201400285A GT 201400285 A GT201400285 A GT 201400285A GT 201400285 A GT201400285 A GT 201400285A
Authority
GT
Guatemala
Prior art keywords
antibodies
formulation
antibody
sugars
waterproof
Prior art date
Application number
GT201400285A
Other languages
English (en)
Inventor
Cosenza Marta
Stark Christoph
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48914378&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT201400285(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT201400285A publication Critical patent/GT201400285A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A LOS ANTICUERPOS ANTI-BAFFR EN FORMULACIÓN LÍQUIDA QUE COMPRENDE UNA ALTA CONCENTRACIÓN DEL INGREDIENTE ACTIVO DE ANTICUERPO PARA LA ENTREGA EN UN PACIENTE SIN ALTOS NIVELES DE AGREGACIÓN DE ANTICUERPOS. LA COMPOSICIÓN FARMACÉUTICA ACUOSA PUEDE INCLUIR UNO O MÁS AZÚCARES, UN AGENTE AMORTIGUADOR, UN SURFACTANTE, Y/O UN AMINOÁCIDO LIBRE
GT201400285A 2012-06-12 2014-12-11 Formulacion de anticuerpos GT201400285A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261658472P 2012-06-12 2012-06-12

Publications (1)

Publication Number Publication Date
GT201400285A true GT201400285A (es) 2015-10-15

Family

ID=48914378

Family Applications (1)

Application Number Title Priority Date Filing Date
GT201400285A GT201400285A (es) 2012-06-12 2014-12-11 Formulacion de anticuerpos

Country Status (35)

Country Link
US (4) US9216219B2 (es)
EP (2) EP3593814B1 (es)
JP (1) JP6265978B2 (es)
KR (1) KR102124820B1 (es)
CN (1) CN104363920B (es)
AR (1) AR091413A1 (es)
AU (1) AU2013276112B2 (es)
BR (1) BR112014030820B1 (es)
CA (1) CA2875386C (es)
CL (1) CL2014003370A1 (es)
CO (1) CO7151487A2 (es)
CY (1) CY1122181T1 (es)
DK (1) DK2858671T3 (es)
EA (1) EA033373B1 (es)
EC (1) ECSP15017314A (es)
ES (1) ES2751659T3 (es)
GT (1) GT201400285A (es)
HR (1) HRP20191827T1 (es)
HU (1) HUE045523T2 (es)
IL (1) IL235966B (es)
LT (1) LT2858671T (es)
MA (1) MA37616A1 (es)
MX (1) MX363380B (es)
MY (1) MY179818A (es)
NZ (1) NZ630885A (es)
PE (1) PE20150200A1 (es)
PH (1) PH12014502778B1 (es)
PL (1) PL2858671T3 (es)
PT (1) PT2858671T (es)
SG (1) SG11201408174UA (es)
SI (1) SI2858671T1 (es)
TN (1) TN2014000488A1 (es)
TW (1) TWI653983B (es)
WO (1) WO2013186700A1 (es)
ZA (1) ZA201408547B (es)

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Also Published As

Publication number Publication date
WO2013186700A1 (en) 2013-12-19
PH12014502778A1 (en) 2015-02-02
PL2858671T3 (pl) 2020-01-31
AR091413A1 (es) 2015-02-04
EA033373B1 (ru) 2019-10-31
AU2013276112B2 (en) 2015-07-09
JP2015521593A (ja) 2015-07-30
EP3593814B1 (en) 2026-01-21
IL235966A0 (en) 2015-01-29
NZ630885A (en) 2016-01-29
DK2858671T3 (da) 2019-10-21
EP2858671A1 (en) 2015-04-15
HUE045523T2 (hu) 2020-01-28
CA2875386C (en) 2022-09-13
PT2858671T (pt) 2019-10-28
US10689451B2 (en) 2020-06-23
MA37616A1 (fr) 2017-08-31
JP6265978B2 (ja) 2018-01-24
US20180051092A1 (en) 2018-02-22
US9216219B2 (en) 2015-12-22
PH12014502778B1 (en) 2015-02-02
PE20150200A1 (es) 2015-02-08
ES2751659T3 (es) 2020-04-01
HK1203146A1 (en) 2015-10-23
CY1122181T1 (el) 2020-11-25
MY179818A (en) 2020-11-16
IL235966B (en) 2020-05-31
US20130344088A1 (en) 2013-12-26
CN104363920A (zh) 2015-02-18
HRP20191827T1 (hr) 2019-12-27
CL2014003370A1 (es) 2015-02-06
SI2858671T1 (sl) 2019-11-29
EA201492292A1 (ru) 2015-04-30
KR102124820B1 (ko) 2020-06-22
EP3593814A1 (en) 2020-01-15
MX363380B (es) 2019-03-21
ECSP15017314A (es) 2018-06-30
AU2013276112A1 (en) 2014-12-18
MX2014015262A (es) 2015-06-23
US20180251564A1 (en) 2018-09-06
LT2858671T (lt) 2019-10-25
SG11201408174UA (en) 2015-01-29
ZA201408547B (en) 2015-12-23
EP2858671B1 (en) 2019-07-24
BR112014030820B1 (pt) 2023-02-07
US9751951B2 (en) 2017-09-05
TW201402144A (zh) 2014-01-16
TWI653983B (zh) 2019-03-21
BR112014030820A2 (pt) 2017-07-25
CN104363920B (zh) 2018-05-04
CA2875386A1 (en) 2013-12-19
KR20150029683A (ko) 2015-03-18
US20160145341A1 (en) 2016-05-26
CO7151487A2 (es) 2014-12-29
TN2014000488A1 (en) 2016-03-30

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