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GT200300231A - Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso - Google Patents

Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso

Info

Publication number
GT200300231A
GT200300231A GT200300231A GT200300231A GT200300231A GT 200300231 A GT200300231 A GT 200300231A GT 200300231 A GT200300231 A GT 200300231A GT 200300231 A GT200300231 A GT 200300231A GT 200300231 A GT200300231 A GT 200300231A
Authority
GT
Guatemala
Prior art keywords
integress
hiv
inhibitors
methods
pharmaceutical compositions
Prior art date
Application number
GT200300231A
Other languages
English (en)
Inventor
Qiyue Hu
Atsuo Kuki
Dawn Marie Nowlin
Michael Bruno Plewe
Hai Wang
Junhu Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200300231A publication Critical patent/GT200300231A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE AL COMPUESTO DE FORMULA GENERAL I QUE APARECE EN EL PRESENTE RESUMEN Y QUE ESTA DIRIGIDO A LA MODULACION O INHIBICION DE LA ENZIMA HIVINTEGRASA POR LO QUE SON DE UTILIDAD EN EL SINDROME DE INMUNODEFICIENCIA ADQUIRIDA (SIDA).
GT200300231A 2002-10-31 2003-10-24 Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso GT200300231A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42251302P 2002-10-31 2002-10-31

Publications (1)

Publication Number Publication Date
GT200300231A true GT200300231A (es) 2004-06-23

Family

ID=32230367

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200300231A GT200300231A (es) 2002-10-31 2003-10-24 Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso

Country Status (16)

Country Link
US (3) US7135482B2 (es)
EP (1) EP1558611B1 (es)
JP (1) JP2006506398A (es)
AR (1) AR041864A1 (es)
AT (1) ATE454385T1 (es)
AU (1) AU2003269421A1 (es)
BR (1) BR0315820A (es)
CA (1) CA2500487A1 (es)
DE (1) DE60330890D1 (es)
GT (1) GT200300231A (es)
MX (1) MXPA05004343A (es)
NL (1) NL1024676C2 (es)
PA (1) PA8586801A1 (es)
TW (1) TW200424199A (es)
UY (1) UY28048A1 (es)
WO (1) WO2004039803A2 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
MXPA05007563A (es) 2003-01-27 2005-09-21 Pfizer Inhibidores de la integrasa del vih, composiciones farmaceuticas y metodos para su uso.
ES2292123T3 (es) * 2004-04-26 2008-03-01 Pfizer Inc. Inhibidores de la enzima integrasa de vih.
BRPI0510319A (pt) * 2004-04-26 2007-10-16 Pfizer inibidores da enzima integrase de hiv
EP1873155A1 (en) * 2004-04-26 2008-01-02 Pfizer Inc. Inhibitors of the HIV integrase enzyme
US20070232644A1 (en) * 2004-09-07 2007-10-04 Pfizer Inc. Inhibitors of the Hiv Integrase Enzyme
US7745459B2 (en) 2004-09-21 2010-06-29 Japan Tobacco Inc. Quinolizinone compound and use thereof as HIV integrase inhibitor
DE102005015005A1 (de) * 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
CA2607151C (en) * 2005-05-10 2012-06-19 Merck & Co., Inc. Hiv integrase inhibitors
US20090170846A1 (en) * 2005-10-03 2009-07-02 Pfizer Inc Inhibitors of the hiv integrase enzyme
AP2008004400A0 (en) * 2005-10-07 2008-04-30 Pfizer Prod Inc Inhibitors of HIV integrase enzyme
US20080079207A1 (en) * 2006-09-28 2008-04-03 Williams Controils Industries, Inc. Methods and apparatus for a lever control
AU2009253812A1 (en) * 2008-06-04 2009-12-10 Ambrilia Biopharma Inc. HIV integrase inhibitors from pyridoxine
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
EP2516008B1 (en) * 2009-12-23 2014-04-16 Katholieke Universiteit Leuven Novel antiviral compounds
JP2013542243A (ja) 2010-11-15 2013-11-21 カトリーケ ウニヴェルシテイト ルーヴェン 新規な抗ウイルス性化合物
WO2013082476A1 (en) 2011-11-30 2013-06-06 Emory University Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections
GB201321735D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
GB8720125D0 (en) 1987-08-26 1987-09-30 Roussel Lab Ltd Chemical compounds
EP0627436A1 (en) * 1991-08-08 1994-12-07 TSUMURA & CO. Carcinostatic compound and production thereof
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
US5262537A (en) * 1993-03-19 1993-11-16 Anaquest, Inc. Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid
EP0713877A1 (en) * 1993-07-19 1996-05-29 LUO, Xuande Qinghaosu derivatives against aids
GB2306476A (en) * 1995-10-27 1997-05-07 Merck & Co Inc Hiv integrase inhibitors
US6057297A (en) 1996-08-06 2000-05-02 Polifarma S.P.A. Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof
FR2754262B1 (fr) 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
WO1998018473A1 (en) * 1996-10-31 1998-05-07 Merck & Co., Inc. Benzodiazepine hydrazide derivatives as inhibitors of hiv integrase
GB2327674A (en) * 1997-07-29 1999-02-03 Merck & Co Inc HIV integrase inhibitors
US6403347B1 (en) * 1998-02-03 2002-06-11 Merck & Co., Inc. HIV integrase inhibitors
AU761020B2 (en) 1998-06-12 2003-05-29 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Beta-carboline compounds
CA2372791A1 (en) * 1999-05-12 2000-11-16 Nouri Neamati Thiazepine and oxazepine inhibitors of hiv-1 integrase
US6245806B1 (en) * 1999-08-03 2001-06-12 Merck & Co., Inc. HIV integrase inhibitors
WO2001027309A1 (en) * 1999-10-13 2001-04-19 Merck & Co., Inc. Hiv integrase inhibitors
EP1209158A1 (en) 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substituted beta-carbolines
EP1322599A2 (en) * 2000-06-16 2003-07-02 Bristol-Myers Squibb Company Hiv integrase inhibitors
WO2002002516A2 (en) * 2000-06-30 2002-01-10 Thomas Jefferson University Inhibitors of hiv integrase
JP4176477B2 (ja) * 2001-03-01 2008-11-05 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環誘導体
IL157638A0 (en) 2001-03-01 2004-03-28 Shionogi & Co Nitrogen-containing heteroaryl compounds having hiv integrase inhibitory activity
JP2003171381A (ja) 2001-09-25 2003-06-20 Takeda Chem Ind Ltd エントリー阻害剤
JP2003119137A (ja) 2001-10-10 2003-04-23 Japan Tobacco Inc Ｈｉｖ阻害剤
US6933303B2 (en) 2001-10-19 2005-08-23 Transtech Pharma, Inc. Heteroaryl-fused nitrogen heterocycles as therapeutic agents
SI1441734T1 (sl) 2001-10-26 2007-08-31 Angeletti P Ist Richerche Bio Dihidropirimidin karboksamidni inhibitorji HIV-integraze
WO2003047564A1 (en) 2001-12-05 2003-06-12 Shionogi & Co., Ltd. Derivative having hiv integrase inhibitory activity
CN1617849A (zh) 2001-12-12 2005-05-18 布里斯托尔-迈尔斯斯奎布公司 Hiv整合酶抑制剂
ATE370948T1 (de) 2002-01-17 2007-09-15 Merck & Co Inc Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen
JP4494020B2 (ja) 2002-03-15 2010-06-30 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラーゼ阻害剤として有用なｎ−（置換ベンジル）−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミド
WO2003082881A2 (en) * 2002-03-28 2003-10-09 Procyon Biopharma Inc. Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors
WO2003086319A2 (en) * 2002-04-10 2003-10-23 Merck & Co., Inc. Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant
WO2004035076A1 (en) 2002-10-15 2004-04-29 Chiron Corporation Treatment of tnf-alpha-mediated disorders with casein kinase i epsilon inhibitors
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
MXPA05007563A (es) 2003-01-27 2005-09-21 Pfizer Inhibidores de la integrasa del vih, composiciones farmaceuticas y metodos para su uso.
BRPI0510319A (pt) 2004-04-26 2007-10-16 Pfizer inibidores da enzima integrase de hiv
ES2292123T3 (es) 2004-04-26 2008-03-01 Pfizer Inc. Inhibidores de la enzima integrasa de vih.
US20070232644A1 (en) 2004-09-07 2007-10-04 Pfizer Inc. Inhibitors of the Hiv Integrase Enzyme

Also Published As

Publication number Publication date
AR041864A1 (es) 2005-06-01
TW200424199A (en) 2004-11-16
AU2003269421A1 (en) 2004-05-25
DE60330890D1 (de) 2010-02-25
AU2003269421A8 (en) 2004-05-25
US20070004768A1 (en) 2007-01-04
EP1558611A2 (en) 2005-08-03
US20080221154A1 (en) 2008-09-11
WO2004039803A2 (en) 2004-05-13
JP2006506398A (ja) 2006-02-23
NL1024676C2 (nl) 2005-12-14
WO2004039803A3 (en) 2004-09-16
PA8586801A1 (es) 2005-02-04
UY28048A1 (es) 2004-05-31
MXPA05004343A (es) 2005-08-03
US20040147547A1 (en) 2004-07-29
BR0315820A (pt) 2005-09-13
CA2500487A1 (en) 2004-05-13
EP1558611B1 (en) 2010-01-06
NL1024676A1 (nl) 2004-05-06
ATE454385T1 (de) 2010-01-15
US7135482B2 (en) 2006-11-14
US7368571B2 (en) 2008-05-06

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