GT200100113AA - NEW PROCEDURE FOR THE PREPARATION OF PIRAZOLOPIRIMIDINONAS. - Google Patents
NEW PROCEDURE FOR THE PREPARATION OF PIRAZOLOPIRIMIDINONAS.Info
- Publication number
- GT200100113AA GT200100113AA GT200100113AK GT200100113K GT200100113AA GT 200100113A A GT200100113A A GT 200100113AA GT 200100113A K GT200100113A K GT 200100113AK GT 200100113 K GT200100113 K GT 200100113K GT 200100113A A GT200100113A A GT 200100113AA
- Authority
- GT
- Guatemala
- Prior art keywords
- new procedure
- pirazolopirimidinonas
- preparation
- alquilpiperazinil
- pirimidin
- Prior art date
Links
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- BNRNXUUZRGQAQC-UHFFFAOYSA-N Sildenafil Natural products CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 229940094720 viagra Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
ESTA INVENCION SE REFIERE A UN NUEVO PROCEDIMIENTO PARA LA PRODUCCIÓN DE DERIVADOS DE 4-ALQUILPIPERAZINIL-SULFONILFENIL- Y 4-ALQUILPIPERAZINIL-SULFONIL-PIRIDINIL-DIHIDROPIRAZOLO[4,3D]PIRIMIDIN-7-ONA Y EN PARTICULAR EL FARMACO ANTIIMPOTENCIA SILDENAFILO Y SUS ANÁLOGOS. EL SIDENAFILO (5-[2-ETOXI-5-(4-METILPIPERAZIN-1-ILSULFONIL)FENIL]-1-METIL-3-N-PROPIL-1,6-DIHIDRO-7H-PIRAZOLO[4,3-D]PIRIMIDIN-7-ONA) QUE ES EL INGREDIENTE ACTIVO EN EL VIAGRA.THIS INVENTION CONCERNS A NEW PROCEDURE FOR THE PRODUCTION OF DERIVATIVES OF 4-ALQUILPIPERAZINIL-SULFONILFENIL- AND 4-ALQUILPIPERAZINIL-SULFONIL-PIRIDINIL-DIHIDROPIRAZOLO [4,3D] PIRIMIDIN-7-ANTIOOSPANO SILICA AND PARAFILO ANCIENTO FARM . SIDENAFILO (5- [2-ETOXI-5- (4-METHYLPIPERAZIN-1-ILSULPHONYL) PHENYL] -1-METHYL-3-N-PROPIL-1,6-DIHYDRO-7H-PIRAZOLO [4,3-D] PIRIMIDIN-7-ONA) WHAT IS THE ACTIVE INGREDIENT IN THE VIAGRA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0015462A GB0015462D0 (en) | 2000-06-22 | 2000-06-22 | Novel process for the preparation of pyrazolopyrimidinones |
| GB0105878A GB0105878D0 (en) | 2001-03-09 | 2001-03-09 | Novel process for the preparation of pyrazoloprimidinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT200100113AA true GT200100113AA (en) | 2006-04-10 |
Family
ID=26244537
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT200100113AK GT200100113AA (en) | 2000-06-22 | 2001-06-14 | NEW PROCEDURE FOR THE PREPARATION OF PIRAZOLOPIRIMIDINONAS. |
| GT200100113A GT200100113A (en) | 2000-06-22 | 2001-06-14 | NEW PROCEDURE FOR THE PREPARATION OF PIRAZOLOPIRIMIDINONAS |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT200100113A GT200100113A (en) | 2000-06-22 | 2001-06-14 | NEW PROCEDURE FOR THE PREPARATION OF PIRAZOLOPIRIMIDINONAS |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1296983B1 (en) |
| JP (1) | JP2004501154A (en) |
| KR (1) | KR100525699B1 (en) |
| AP (1) | AP2001002195A0 (en) |
| AR (1) | AR028729A1 (en) |
| AT (1) | ATE282619T1 (en) |
| AU (2) | AU6259201A (en) |
| BR (1) | BR0111864A (en) |
| CA (1) | CA2411957C (en) |
| CZ (1) | CZ20024130A3 (en) |
| DE (1) | DE60107248T2 (en) |
| ES (1) | ES2231498T3 (en) |
| GT (2) | GT200100113AA (en) |
| HU (1) | HUP0301207A3 (en) |
| IL (1) | IL152983A0 (en) |
| MX (1) | MXPA02012887A (en) |
| MY (1) | MY127737A (en) |
| PA (1) | PA8520001A1 (en) |
| PE (1) | PE20020091A1 (en) |
| PL (1) | PL360299A1 (en) |
| PT (1) | PT1296983E (en) |
| SV (1) | SV2002000502A (en) |
| TN (1) | TNSN01092A1 (en) |
| WO (1) | WO2001098303A1 (en) |
| YU (1) | YU84702A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2310144B1 (en) | 2007-06-15 | 2010-01-12 | Galenicum Health, S.L. | INTERMEDIATES FOR THE PREPARATION OF A TYPE 5 PHOSPHODIESTERASE INHIBITOR. |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9013750D0 (en) * | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| GB9612514D0 (en) * | 1996-06-14 | 1996-08-14 | Pfizer Ltd | Novel process |
| US6087368A (en) * | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
| AU5995699A (en) * | 1998-10-23 | 2000-05-15 | Bunnage, Mark Edward | Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction |
-
2001
- 2001-06-07 JP JP2002504259A patent/JP2004501154A/en not_active Ceased
- 2001-06-07 AU AU6259201A patent/AU6259201A/en active Pending
- 2001-06-07 ES ES01936729T patent/ES2231498T3/en not_active Expired - Lifetime
- 2001-06-07 DE DE60107248T patent/DE60107248T2/en not_active Expired - Fee Related
- 2001-06-07 AP APAP/P/2001/002195A patent/AP2001002195A0/en unknown
- 2001-06-07 YU YU84702A patent/YU84702A/en unknown
- 2001-06-07 AT AT01936729T patent/ATE282619T1/en not_active IP Right Cessation
- 2001-06-07 EP EP01936729A patent/EP1296983B1/en not_active Expired - Lifetime
- 2001-06-07 WO PCT/IB2001/001038 patent/WO2001098303A1/en not_active Ceased
- 2001-06-07 CZ CZ20024130A patent/CZ20024130A3/en unknown
- 2001-06-07 HU HU0301207A patent/HUP0301207A3/en unknown
- 2001-06-07 IL IL15298301A patent/IL152983A0/en unknown
- 2001-06-07 PL PL36029901A patent/PL360299A1/en not_active Application Discontinuation
- 2001-06-07 PT PT01936729T patent/PT1296983E/en unknown
- 2001-06-07 CA CA002411957A patent/CA2411957C/en not_active Expired - Fee Related
- 2001-06-07 KR KR10-2002-7017475A patent/KR100525699B1/en not_active Expired - Fee Related
- 2001-06-07 MX MXPA02012887A patent/MXPA02012887A/en active IP Right Grant
- 2001-06-07 AU AU2001262592A patent/AU2001262592B2/en not_active Ceased
- 2001-06-07 BR BR0111864-1A patent/BR0111864A/en not_active IP Right Cessation
- 2001-06-14 GT GT200100113AK patent/GT200100113AA/en unknown
- 2001-06-14 GT GT200100113A patent/GT200100113A/en unknown
- 2001-06-15 AR ARP010102878A patent/AR028729A1/en unknown
- 2001-06-18 PE PE2001000586A patent/PE20020091A1/en not_active Application Discontinuation
- 2001-06-19 PA PA20018520001A patent/PA8520001A1/en unknown
- 2001-06-19 MY MYPI20012890A patent/MY127737A/en unknown
- 2001-06-21 SV SV2001000502A patent/SV2002000502A/en not_active Application Discontinuation
- 2001-06-21 TN TNTNSN01092A patent/TNSN01092A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1079198A1 (en) | 2006-03-31 |
| KR100525699B1 (en) | 2005-11-03 |
| HUP0301207A2 (en) | 2003-08-28 |
| AU2001262592B2 (en) | 2006-07-06 |
| SV2002000502A (en) | 2002-07-03 |
| WO2001098303A1 (en) | 2001-12-27 |
| BR0111864A (en) | 2003-07-01 |
| PT1296983E (en) | 2005-02-28 |
| ES2231498T3 (en) | 2005-05-16 |
| DE60107248D1 (en) | 2004-12-23 |
| YU84702A (en) | 2005-09-19 |
| CA2411957C (en) | 2007-09-18 |
| KR20030017556A (en) | 2003-03-03 |
| HUP0301207A3 (en) | 2006-02-28 |
| MY127737A (en) | 2006-12-29 |
| GT200100113A (en) | 2002-06-04 |
| DE60107248T2 (en) | 2005-12-01 |
| AP2001002195A0 (en) | 2002-12-21 |
| MXPA02012887A (en) | 2003-05-14 |
| AU6259201A (en) | 2002-01-02 |
| EP1296983B1 (en) | 2004-11-17 |
| PA8520001A1 (en) | 2003-09-05 |
| PL360299A1 (en) | 2004-09-06 |
| CZ20024130A3 (en) | 2004-01-14 |
| PE20020091A1 (en) | 2002-02-21 |
| CA2411957A1 (en) | 2001-12-27 |
| JP2004501154A (en) | 2004-01-15 |
| IL152983A0 (en) | 2003-06-24 |
| EP1296983A1 (en) | 2003-04-02 |
| TNSN01092A1 (en) | 2005-11-10 |
| AR028729A1 (en) | 2003-05-21 |
| ATE282619T1 (en) | 2004-12-15 |
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