GT200000087A - Formas polimorfas de un citrato de azabiciclo(2.2.2) octan - 3 - amina y sus composiciones farmaceuticas. - Google Patents
Formas polimorfas de un citrato de azabiciclo(2.2.2) octan - 3 - amina y sus composiciones farmaceuticas.Info
- Publication number
- GT200000087A GT200000087A GT200000087A GT200000087A GT200000087A GT 200000087 A GT200000087 A GT 200000087A GT 200000087 A GT200000087 A GT 200000087A GT 200000087 A GT200000087 A GT 200000087A GT 200000087 A GT200000087 A GT 200000087A
- Authority
- GT
- Guatemala
- Prior art keywords
- pharmaceutical compositions
- citrate
- amina
- octan
- azabiciclo
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 title abstract 2
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 title abstract 2
- 206010047700 Vomiting Diseases 0.000 abstract 2
- 241000459479 Capsula Species 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001860 citric acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 239000006186 oral dosage form Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UNA SAL CITRATO MONOHIDRATO DE AZOBICICLO[2.2.2.] OCTAN 3 AMINA Y SUS COMPOSICIONES FARMACEUTICAS DE ACUERDO A LA FORMULA I, EN SU FORMA ANHIDRA, A SU FORMA CRISTALINA POLIMORFA A INDIVIDUAL, Y A SUS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. LA INVENCION TAMBIEN SE REFIERE A UN ANTAGONISTA DEL RECEPTOR NK1 ACTIVO DEL SNC PARA EL TRATAMIENTO DE LA EMESIS EN UN MAMIFERO, INCLUYENDO EL SER HUMANO. EN LA FORMA CITRATO DEL COMPUESTO ESTE TIENE LA ESTABILIDAD NECESARIA PARA TRATAR LA EMESIS; Y SU ADMINISTRACION SE REFIERE A UNA FORMA DE DOSIFICACION ORAL DE LIBERACION INMEDIATA, PREFERIBLEMENTE EN FORMA DE COMPRIMIDO O CAPSULA, O INTRAVENOSA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13699299P | 1999-06-01 | 1999-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT200000087A true GT200000087A (es) | 2001-11-22 |
Family
ID=22475338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT200000087A GT200000087A (es) | 1999-06-01 | 2000-05-31 | Formas polimorfas de un citrato de azabiciclo(2.2.2) octan - 3 - amina y sus composiciones farmaceuticas. |
Country Status (48)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1713506A1 (en) * | 2004-01-30 | 2006-10-25 | Pfizer Products Incorporated | Pharmaceutical compositions of neurokinin receptor antagonists and cyclodextrin and methods for improved injection site toleration |
| JP2007519701A (ja) * | 2004-01-30 | 2007-07-19 | ファイザー・プロダクツ・インク | 麻酔回復を改善するためのｎｋ−１受容体拮抗剤 |
| RU2332997C2 (ru) * | 2004-01-30 | 2008-09-10 | Пфайзер Продактс Инк. | АНТИМИКРОБНЫЕ КОНСЕРВАНТЫ ДЛЯ ДОСТИЖЕНИЯ МУЛЬТИДОЗОВЫХ РЕЦЕПТУР С ИСПОЛЬЗОВАНИЕМ β-ЦИКЛОДЕКСТРИНОВ ДЛЯ ЖИДКИХ ЛЕКАРСТВЕННЫХ ФОРМ |
| RU2320659C9 (ru) * | 2004-02-02 | 2008-07-20 | Пфайзер Продактс Инк. | Способы получения 1-(2s, 3s)-2-бензгидрил-n-(5-трет-бутил-2-метоксибензил)хинуклидин-3-амина в виде камфорсульфатной соли, цитратной соли и свободного основания и промежуточное соединение |
| EP2968152B2 (en) * | 2013-03-15 | 2022-06-22 | Pearl Therapeutics, Inc. | Methods and systems for conditioning of particulate crystalline materials |
| CN110577522B (zh) * | 2018-06-07 | 2022-12-27 | 东莞市东阳光动物保健药品有限公司 | 马罗匹坦柠檬酸盐新晶型及其制备方法 |
| CN112979639B (zh) * | 2019-12-16 | 2025-08-08 | 凯默斯医药科技(上海)有限公司 | 一种马罗皮坦新晶型及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0733386B2 (ja) * | 1991-05-31 | 1995-04-12 | フアイザー・インコーポレイテツド | キヌクリジン誘導体 |
| US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
| US5576317A (en) * | 1994-12-09 | 1996-11-19 | Pfizer Inc. | NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis |
-
2000
- 2000-05-08 US US09/566,307 patent/US6255320B1/en not_active Expired - Lifetime
- 2000-05-17 HN HN2000000077A patent/HN2000000077A/es unknown
- 2000-05-18 DK DK00925528T patent/DK1181290T3/da active
- 2000-05-18 SI SI200030161T patent/SI1181290T1/xx unknown
- 2000-05-18 AP APAP/P/2001/002349A patent/AP2001002349A0/en unknown
- 2000-05-18 MX MXPA01012325A patent/MXPA01012325A/es unknown
- 2000-05-18 EA EA200101108A patent/EA003731B1/ru active Protection Beyond IP Right Term
- 2000-05-18 IL IL14640600A patent/IL146406A0/xx not_active IP Right Cessation
- 2000-05-18 UA UA2001118214A patent/UA66925C2/uk unknown
- 2000-05-18 WO PCT/IB2000/000665 patent/WO2000073304A1/en not_active Ceased
- 2000-05-18 AU AU44248/00A patent/AU767334B2/en not_active Expired
- 2000-05-18 DE DE60003679T patent/DE60003679T2/de not_active Expired - Lifetime
- 2000-05-18 CZ CZ20014269A patent/CZ295819B6/cs not_active IP Right Cessation
- 2000-05-18 HR HR20010904A patent/HRP20010904A2/hr not_active Application Discontinuation
- 2000-05-18 PT PT00925528T patent/PT1181290E/pt unknown
- 2000-05-18 YU YU81101A patent/YU81101A/sh unknown
- 2000-05-18 PL PL00352716A patent/PL196046B1/pl not_active IP Right Cessation
- 2000-05-18 HU HU0201301A patent/HUP0201301A3/hu unknown
- 2000-05-18 BR BR0011094-9A patent/BR0011094A/pt not_active Application Discontinuation
- 2000-05-18 KR KR10-2001-7015494A patent/KR100476606B1/ko not_active Expired - Fee Related
- 2000-05-18 AT AT00925528T patent/ATE244239T1/de not_active IP Right Cessation
- 2000-05-18 CN CNB008082782A patent/CN1146565C/zh not_active Expired - Lifetime
- 2000-05-18 EP EP00925528A patent/EP1181290B1/en not_active Expired - Lifetime
- 2000-05-18 ES ES00925528T patent/ES2199825T3/es not_active Expired - Lifetime
- 2000-05-18 EE EEP200100656A patent/EE200100656A/xx unknown
- 2000-05-18 JP JP2001500629A patent/JP3830816B2/ja not_active Expired - Lifetime
- 2000-05-18 CA CA002372238A patent/CA2372238C/en not_active Expired - Lifetime
- 2000-05-18 NZ NZ515349A patent/NZ515349A/xx unknown
- 2000-05-18 OA OA1200100318A patent/OA11956A/en unknown
- 2000-05-18 SK SK1733-2001A patent/SK285820B6/sk not_active IP Right Cessation
- 2000-05-18 TR TR2001/03473T patent/TR200103473T2/xx unknown
- 2000-05-23 PA PA20008496101A patent/PA8496101A1/es unknown
- 2000-05-26 CO CO00039195A patent/CO5170463A1/es not_active Application Discontinuation
- 2000-05-26 TW TW089110206A patent/TWI285204B/zh not_active IP Right Cessation
- 2000-05-29 UY UY26176A patent/UY26176A1/es not_active Application Discontinuation
- 2000-05-30 AR ARP000102663A patent/AR033331A1/es active IP Right Grant
- 2000-05-30 MY MYPI20002409A patent/MY133508A/en unknown
- 2000-05-30 PE PE2000000520A patent/PE20010209A1/es not_active Application Discontinuation
- 2000-05-31 TN TNTNSN00120A patent/TNSN00120A1/fr unknown
- 2000-05-31 GT GT200000087A patent/GT200000087A/es unknown
- 2000-05-31 SV SV2000000093A patent/SV2001000093A/es unknown
- 2000-05-31 MA MA25997A patent/MA26742A1/fr unknown
- 2000-05-31 DZ DZ000101A patent/DZ3050A1/xx active
- 2000-06-01 EC EC2000003508A patent/ECSP003508A/es unknown
-
2001
- 2001-11-28 ZA ZA200109775A patent/ZA200109775B/en unknown
- 2001-11-30 NO NO20015848A patent/NO20015848L/no not_active Application Discontinuation
- 2001-12-10 BG BG106204A patent/BG65240B1/bg unknown
-
2007
- 2007-03-27 CY CY2007011C patent/CY2007011I2/el unknown
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