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GT199800075A - Derivados de macrolidos c-4" sustituidos. - Google Patents

Derivados de macrolidos c-4" sustituidos.

Info

Publication number
GT199800075A
GT199800075A GT199800075A GT199800075A GT199800075A GT 199800075 A GT199800075 A GT 199800075A GT 199800075 A GT199800075 A GT 199800075A GT 199800075 A GT199800075 A GT 199800075A GT 199800075 A GT199800075 A GT 199800075A
Authority
GT
Guatemala
Prior art keywords
substituted
derivatives
macrolides
birds
mammals
Prior art date
Application number
GT199800075A
Other languages
English (en)
Inventor
Brian Scott Bronk
Takushi Kaneko
Michael Anthony Letavic
Hengmiao Cheng
Edward Alan Glazer
Bingwei Vera Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT199800075A publication Critical patent/GT199800075A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

ESTA INVENCION SE REFIERE A LOS NUEVOS DERIVADOS DE MACROLIDOS C4" SUSTITUIDOS QUE SON UTILES COMO AGENTES ANTIBACTERIANOS Y ANTIPROTOZOOS EN MAMIFEROS, INCLUYENDO EL HOMBRE, ASI COMO EN PECES Y AVES. ESTA INVENCION TAMBIEN SE REFIERE A LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS NUEVOS COMPUESTOS Y A LOS METODOS PARA EL TRATAMIENTO DE LAS INFECCIONES BACTERIANAS Y PROTOZOARIAS EN MAMIFEROS, PECES Y AVES, MEDIANTE LA ADMINISTRACION DE LOS COMPUESTOS NUEVOS. ESTOS COMPUESTOS TIENEN LA ESTRUCTURA QUIMICA (I), DESCRITA EN EL EXPEDIENTE.
GT199800075A 1997-06-11 1998-06-08 Derivados de macrolidos c-4" sustituidos. GT199800075A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4998097P 1997-06-11 1997-06-11

Publications (1)

Publication Number Publication Date
GT199800075A true GT199800075A (es) 1999-11-30

Family

ID=21962765

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199800075A GT199800075A (es) 1997-06-11 1998-06-08 Derivados de macrolidos c-4" sustituidos.

Country Status (39)

Country Link
EP (1) EP0988309B1 (es)
JP (1) JP3262806B2 (es)
KR (1) KR100369959B1 (es)
CN (1) CN1145636C (es)
AP (1) AP1189A (es)
AR (1) AR013085A1 (es)
AT (1) ATE310742T1 (es)
AU (1) AU745006C (es)
BG (1) BG64357B1 (es)
BR (1) BR9810097A (es)
CA (1) CA2293397C (es)
CO (1) CO4950584A1 (es)
DE (1) DE69832486T2 (es)
DZ (1) DZ2515A1 (es)
EA (1) EA002440B1 (es)
ES (1) ES2251081T3 (es)
GT (1) GT199800075A (es)
HN (1) HN1998000074A (es)
HR (1) HRP980315A2 (es)
HU (1) HUP0004076A3 (es)
ID (1) ID24530A (es)
IL (1) IL132808A (es)
IS (1) IS1979B (es)
MA (1) MA24563A1 (es)
MY (1) MY133027A (es)
NO (1) NO315560B1 (es)
NZ (1) NZ500652A (es)
OA (1) OA11226A (es)
PA (1) PA8452001A1 (es)
PE (1) PE79999A1 (es)
PL (1) PL337497A1 (es)
SK (1) SK168299A3 (es)
TN (1) TNSN98084A1 (es)
TW (2) TWI224106B (es)
UA (1) UA70298A (es)
UY (1) UY25041A1 (es)
WO (1) WO1998056801A1 (es)
YU (1) YU62999A (es)
ZA (1) ZA985016B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU731842B2 (en) * 1997-09-10 2001-04-05 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
BR9914998A (pt) 1998-11-03 2001-07-10 Pfizer Prod Inc Antibióticos macrólidos
CA2292359C (en) * 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
AU6748500A (en) * 1999-08-24 2001-03-19 Abbott Laboratories 9a-azalides with antibacterial activity
AU779748C (en) * 2000-01-27 2005-12-08 Zoetis Services Llc Azalide antibiotic compositions
RU2263117C2 (ru) * 2001-04-27 2005-10-27 Пфайзер Продактс Инк. Способ получения 4"-замещенных производных 9-деоксо-9а-аза-9а-гомоэритромицина а
JP2003040782A (ja) * 2001-05-31 2003-02-13 Pfizer Prod Inc アザリド抗生物質組成物
BR0312634A (pt) 2002-07-08 2005-05-10 Pliva Istrazivacki Inst D O O Novos compostos, composições e métodos para tratamento de doenças e condições inflamatórias
HRP20050002A2 (en) 2002-07-08 2006-03-31 Pliva-Istra�iva�ki institut d.o.o. Novel compounds, compositions as carriers for steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
JP2005536488A (ja) * 2002-07-08 2005-12-02 プリヴァ−イストラジヴァキ・インスティトゥ・ディー・オー・オー 新規な非ステロイド抗炎症物質、組成物、およびその使用方法
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
EP3738591A3 (en) * 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
WO2005085266A2 (en) 2004-02-27 2005-09-15 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US8293715B2 (en) 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
WO2009055557A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
EP2287173A4 (en) 2008-05-15 2013-06-19 Taisho Pharmaceutical Co Ltd 10A AZALIDE COMPOUND WITH 4-LOW RING STRUCTURE
HRP20160222T1 (hr) 2008-10-24 2016-04-08 Cempra Pharmaceuticals, Inc. Biozaštite uporabom makrolida koji sadrže triazol
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US8940880B2 (en) * 2010-09-20 2015-01-27 Novartis Ag Process for the preparation of 9-deoxo-9a-homoerythromycin A, modified in the C-4″ of the cladinose ring by an epoxide group
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
HK1205939A1 (en) 2012-03-27 2015-12-31 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 Ｃ−４”位置換マクロライド誘導体を含有する医薬
CA3130061C (en) * 2013-04-04 2024-05-28 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
CN105669798B (zh) * 2013-08-23 2019-07-26 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN103965273B (zh) * 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
US10633407B2 (en) 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
JP2018509452A (ja) 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CA3175087A1 (en) * 2020-03-12 2021-09-16 Zoetis Services Llc Immunomodulating o-het/aryl azalides

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150220A (en) * 1977-02-04 1979-04-17 Pfizer Inc. Semi-synthetic 4"-erythromycin A derivatives
SE445223B (sv) * 1977-02-04 1986-06-09 Pfizer Sett att framstella 4"-amino-erytomylin-a-derivat
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
GR80277B (en) * 1983-09-06 1985-01-04 Pfizer Azahomoerythromycin b derivatives and intermediates therefor
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US5412982A (en) * 1994-03-10 1995-05-09 Potts; James K. Windsock support

Also Published As

Publication number Publication date
TW200418871A (en) 2004-10-01
JP2000514097A (ja) 2000-10-24
NO996107D0 (no) 1999-12-10
DE69832486D1 (de) 2005-12-29
AP1189A (en) 2003-07-16
OA11226A (en) 2003-07-16
EP0988309A1 (en) 2000-03-29
HRP980315A2 (en) 1999-04-30
PE79999A1 (es) 1999-08-25
IL132808A0 (en) 2001-03-19
AR013085A1 (es) 2000-12-13
CN1259955A (zh) 2000-07-12
PL337497A1 (en) 2000-08-28
KR100369959B1 (ko) 2003-02-12
IS1979B (is) 2005-01-14
ID24530A (id) 2000-07-20
DE69832486T2 (de) 2006-07-27
TNSN98084A1 (fr) 2005-03-15
PA8452001A1 (es) 2000-05-24
NO315560B1 (no) 2003-09-22
NO996107L (no) 2000-02-10
AU745006B2 (en) 2002-03-07
SK168299A3 (en) 2000-09-12
ES2251081T3 (es) 2006-04-16
HN1998000074A (es) 1999-01-08
EA199901014A1 (ru) 2000-06-26
IS5250A (is) 1999-11-16
CO4950584A1 (es) 2000-09-01
NZ500652A (en) 2001-10-26
ZA985016B (en) 1999-12-10
BG103969A (en) 2000-07-31
CA2293397C (en) 2004-08-31
HUP0004076A3 (en) 2003-05-28
EA002440B1 (ru) 2002-04-25
DZ2515A1 (fr) 2003-02-01
AU7228198A (en) 1998-12-30
WO1998056801A1 (en) 1998-12-17
UA70298C2 (uk) 2004-10-15
TWI224106B (en) 2004-11-21
JP3262806B2 (ja) 2002-03-04
UA70298A (uk) 2004-10-15
ATE310742T1 (de) 2005-12-15
YU62999A (sh) 2002-10-18
KR20010013633A (ko) 2001-02-26
EP0988309B1 (en) 2005-11-23
IL132808A (en) 2004-08-31
BG64357B1 (bg) 2004-11-30
MY133027A (en) 2007-10-31
HUP0004076A2 (hu) 2001-04-28
AP9801254A0 (en) 1998-06-30
MA24563A1 (fr) 1998-12-31
HK1025974A1 (en) 2000-12-01
CN1145636C (zh) 2004-04-14
AU745006C (en) 2006-02-23
UY25041A1 (es) 2000-09-29
BR9810097A (pt) 2000-08-08
CA2293397A1 (en) 1998-12-17

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