GR900100076A - Preparation method of novel pharmaceutical forms of cyclosporine - Google Patents
Preparation method of novel pharmaceutical forms of cyclosporineInfo
- Publication number
- GR900100076A GR900100076A GR90100076A GR900100076A GR900100076A GR 900100076 A GR900100076 A GR 900100076A GR 90100076 A GR90100076 A GR 90100076A GR 900100076 A GR900100076 A GR 900100076A GR 900100076 A GR900100076 A GR 900100076A
- Authority
- GR
- Greece
- Prior art keywords
- cyclosporine
- alkylene
- glycol
- preparation
- pharmaceutical forms
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
- 108010036949 Cyclosporine Proteins 0.000 title abstract 2
- 229960001265 ciclosporin Drugs 0.000 title abstract 2
- 229930182912 cyclosporin Natural products 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 2
- -1 GELUCIR product) Chemical class 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000012188 paraffin wax Substances 0.000 abstract 1
- 229920001515 polyalkylene glycol Polymers 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 229920001296 polysiloxane Polymers 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Pharmaceutical composites containing a) cyclosporine as an active ingredient b) a fatty acid saccharite monoester, and c) a carrier or diluting agent. The ingredients in (c) are, usually, ethanol, one alkylene-glycol (e.g. 1,2-propylene glycol), one alkylene -polyol (e.g. glycerine), one polyalkylene-glycol (e.g. FEG), one alkylene-polyol-ether or ester (e.g. GELUCIR product), hyperfluid or hypofluid paraffin, an organic silicone oxide polymer, whereas ethanol is not such a preferred choice.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898901898A GB8901898D0 (en) | 1989-01-28 | 1989-01-28 | Cane protection caps |
| GB898902901A GB8902901D0 (en) | 1989-02-09 | 1989-02-09 | Improvements in or relating to organic compounds |
| GB898902898A GB8902898D0 (en) | 1989-02-09 | 1989-02-09 | Improvements in or relating to organic compounds |
| GB898903147A GB8903147D0 (en) | 1989-02-13 | 1989-02-13 | Improvements in or relating to organic compounds |
| GB898903663A GB8903663D0 (en) | 1989-02-17 | 1989-02-17 | Improvements in or relating to organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GR900100076A true GR900100076A (en) | 1991-06-28 |
| GR1000466B GR1000466B (en) | 1992-07-30 |
Family
ID=27516885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR900100076A GR1000466B (en) | 1989-01-28 | 1990-02-07 | Preparation method of novel pharmaceutical forms of cyclosporine |
Country Status (1)
| Country | Link |
|---|---|
| GR (1) | GR1000466B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2015339A (en) * | 1978-03-07 | 1979-09-12 | Sandoz Ltd | Compositions comprising mono-cyclic peptides |
| EP0230332A1 (en) * | 1986-01-13 | 1987-07-29 | N.V. Sanico | A pharmaceutical composition with sustained release of the active component and a process for the preparation thereof |
| FR2620336A1 (en) * | 1987-09-15 | 1989-03-17 | Sandoz Sa | USE OF WATER-SOLUBLE MONOESTERS OF FATTY ACIDS AS SOLUBILISANTS OF MEDICAMENTS |
| FR2636534A1 (en) * | 1988-09-16 | 1990-03-23 | Sandoz Sa | PHARMACEUTICAL COMPOSITIONS BASED ON CYCLOSPORINS |
-
1990
- 1990-02-07 GR GR900100076A patent/GR1000466B/en not_active IP Right Cessation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2015339A (en) * | 1978-03-07 | 1979-09-12 | Sandoz Ltd | Compositions comprising mono-cyclic peptides |
| EP0230332A1 (en) * | 1986-01-13 | 1987-07-29 | N.V. Sanico | A pharmaceutical composition with sustained release of the active component and a process for the preparation thereof |
| FR2620336A1 (en) * | 1987-09-15 | 1989-03-17 | Sandoz Sa | USE OF WATER-SOLUBLE MONOESTERS OF FATTY ACIDS AS SOLUBILISANTS OF MEDICAMENTS |
| FR2636534A1 (en) * | 1988-09-16 | 1990-03-23 | Sandoz Sa | PHARMACEUTICAL COMPOSITIONS BASED ON CYCLOSPORINS |
Non-Patent Citations (2)
| Title |
|---|
| CLAIMS SEARCHED: ALL * |
| PHARMACEUTICAL RESEARCH, vol. 6, no. 1, November 1989, pages 958-960, Plenum Publishing Corp., New York, US; L. HAHN et al.: "Solid surfactant solutions of active ingredients in sugar esters" * |
Also Published As
| Publication number | Publication date |
|---|---|
| GR1000466B (en) | 1992-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Right expired |