GR3034379T3 - L-2',3'-dideoxy nucleoside analogs as anti-hepatitis b (hbv) and anti-hiv agents - Google Patents
L-2',3'-dideoxy nucleoside analogs as anti-hepatitis b (hbv) and anti-hiv agentsInfo
- Publication number
- GR3034379T3 GR3034379T3 GR20000402067T GR20000402067T GR3034379T3 GR 3034379 T3 GR3034379 T3 GR 3034379T3 GR 20000402067 T GR20000402067 T GR 20000402067T GR 20000402067 T GR20000402067 T GR 20000402067T GR 3034379 T3 GR3034379 T3 GR 3034379T3
- Authority
- GR
- Greece
- Prior art keywords
- hbv
- dideoxy
- present
- hepatitis
- replication
- Prior art date
Links
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 title abstract 2
- 229940124411 anti-hiv antiviral agent Drugs 0.000 title abstract 2
- 208000006454 hepatitis Diseases 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 150000003833 nucleoside derivatives Chemical class 0.000 title 1
- 241000700721 Hepatitis B virus Species 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 231100000053 low toxicity Toxicity 0.000 abstract 2
- 230000003389 potentiating effect Effects 0.000 abstract 2
- 230000010076 replication Effects 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229960004413 flucytosine Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6729993A | 1993-05-25 | 1993-05-25 | |
| US08/098,650 US5627160A (en) | 1993-05-25 | 1993-07-28 | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
| PCT/US1994/005790 WO1994027616A1 (en) | 1993-05-25 | 1994-05-23 | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis b (hbv) and anti-hiv agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3034379T3 true GR3034379T3 (en) | 2000-12-29 |
Family
ID=26747712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20000402067T GR3034379T3 (en) | 1993-05-25 | 2000-09-08 | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis b (hbv) and anti-hiv agents |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5627160A (el) |
| EP (1) | EP0707481B1 (el) |
| JP (2) | JPH08510747A (el) |
| KR (1) | KR100279953B1 (el) |
| CN (1) | CN1076021C (el) |
| AT (1) | ATE195423T1 (el) |
| CA (1) | CA2163520C (el) |
| DE (1) | DE69425574T2 (el) |
| DK (1) | DK0707481T3 (el) |
| ES (1) | ES2150993T3 (el) |
| GR (1) | GR3034379T3 (el) |
| PT (1) | PT707481E (el) |
| WO (1) | WO1994027616A1 (el) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
| US6069252A (en) | 1990-02-01 | 2000-05-30 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers |
| US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
| US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
| AU7954694A (en) * | 1993-09-10 | 1995-03-27 | Centre National De La Recherche Scientifique (Cnrs) | Nucleosides with anti-hepatitis b virus activity |
| US20020120130A1 (en) * | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
| US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
| US5512431A (en) * | 1994-06-29 | 1996-04-30 | Darwin Molecular Corporation | Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing |
| IL115156A (en) | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
| US5559101A (en) * | 1994-10-24 | 1996-09-24 | Genencor International, Inc. | L-ribofuranosyl nucleosides |
| US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
| US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
| US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
| WO1996028162A1 (en) * | 1995-03-14 | 1996-09-19 | University Of Medicine & Dentistry Of New Jersey | New drug combination for the treatment of viral diseases |
| US5869461A (en) * | 1995-03-16 | 1999-02-09 | Yale University | Reducing toxicity of L-nucleosides with D-nucleosides |
| JP4413996B2 (ja) * | 1995-06-07 | 2010-02-10 | エモリー・ユニバーシティ | 抗ｂ型肝炎ウィルス活性を有するヌクレオシド |
| US5753789A (en) * | 1996-07-26 | 1998-05-19 | Yale University | Oligonucleotides containing L-nucleosides |
| HUP0001186A3 (en) * | 1996-10-16 | 2002-04-29 | Icn Pharmaceuticals Inc Costa | Purine l-nucleosides,analogs and pharmaceutical compositions thereof |
| KR100398923B1 (ko) | 1996-10-16 | 2003-09-19 | 아이씨엔 파마슈티컬스, 인코포레이티드 | 모노시클릭 ｌ-누클레오시드, 이의 유사체 및 이들의 용도 |
| US6509320B1 (en) * | 1996-10-16 | 2003-01-21 | Icn Pharmaceuticals, Inc. | Purine L-nucleosides, analogs and uses thereof |
| EP1132393B1 (en) * | 1996-10-16 | 2003-04-09 | ICN Pharmaceuticals, Inc. | L-Ribavirin and uses thereof |
| US6090602A (en) * | 1998-02-18 | 2000-07-18 | Promelas Research Corporation | Levo-monosaccharide in a nucleoside analog for use as an anti-retroviral agent |
| CN1257912C (zh) * | 1998-08-10 | 2006-05-31 | 艾丹尼克斯(开曼)有限公司 | 用于治疗乙型肝炎的β－L－2′－脱氧－核苷 |
| US7115584B2 (en) * | 1999-01-22 | 2006-10-03 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
| US7635690B2 (en) | 1999-01-22 | 2009-12-22 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
| US6525191B1 (en) * | 1999-05-11 | 2003-02-25 | Kanda S. Ramasamy | Conformationally constrained L-nucleosides |
| US6436948B1 (en) | 2000-03-03 | 2002-08-20 | University Of Georgia Research Foundation Inc. | Method for the treatment of psoriasis and genital warts |
| AU2002255707A1 (en) | 2001-03-15 | 2002-10-03 | Trustees Of Boston College, The | Selective anti-viral nucleoside chain terminators |
| WO2003087119A1 (en) * | 2002-04-12 | 2003-10-23 | Achillion Pharmaceuticals, Inc. | METHOD FOR SYNTHESIZING β-L-FLUORO-2´,3´DIDEHYDROCYTIDINE (β-L-FD4C) |
| US20040067877A1 (en) * | 2002-08-01 | 2004-04-08 | Schinazi Raymond F. | 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections |
| WO2005026186A1 (de) * | 2003-09-12 | 2005-03-24 | Max-Delbrück-Centrum für Molekulare Medizin | Β-l-nucleoside und ihre verwendung als pharmazeutische mittel zur behandlung viraler erkrankungen |
| EP2266579A1 (en) | 2004-10-19 | 2010-12-29 | Achillion Pharmaceuticals, Inc. | Pharmaceutical composition comprising elvucitavine |
| GB0513835D0 (en) * | 2005-07-07 | 2005-08-10 | Medivir Ab | HIV inhibitors |
| CN102066369B (zh) | 2007-06-18 | 2013-05-29 | 广东东阳光药业有限公司 | 一种溴苯基-取代的噻唑二氢嘧啶 |
| US8816074B2 (en) * | 2009-11-16 | 2014-08-26 | University of Georgia Foundation, Inc. | 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections |
| CA2782524A1 (en) * | 2009-12-17 | 2011-06-23 | Novadex Pharmaceuticals Ab | 3'-deoxy-3'-methylidene-.beta.-l-nucleosides |
| CN102234280B (zh) * | 2010-04-26 | 2014-01-08 | 北京大学 | D,l-鸟嘌呤核苷类似物及其制备方法和应用 |
| WO2018092728A1 (ja) | 2016-11-16 | 2018-05-24 | 国立研究開発法人国立国際医療研究センター | 抗ウイルス活性等の生理活性を有するヌクレオシド誘導体 |
| KR102077833B1 (ko) | 2018-12-10 | 2020-02-14 | 류형준 | 기능성 식품조성물 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3817982A (en) * | 1971-12-29 | 1974-06-18 | Syntex Inc | 2{40 ,3{40 -unsaturated nucleosides and method of making |
| DE3689976T2 (de) * | 1985-05-15 | 1995-03-16 | Wellcome Found | Therapeutische Nucleoside und deren Herstellung. |
| US4879277A (en) * | 1985-08-26 | 1989-11-07 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral compositions and methods |
| AU570853B2 (en) * | 1985-08-26 | 1988-03-24 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Inhibition of infectivity and cytopathic effect of htlv-111/ lav by purine bases |
| SE8602981D0 (sv) * | 1986-07-04 | 1986-07-04 | Astra Laekemedel Ab | Novel medicinal use |
| US4788181A (en) * | 1986-09-29 | 1988-11-29 | The United States Of America As Represented By The Department Of Health And Human Services | 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity |
| EP0285884A3 (en) * | 1987-03-20 | 1990-07-04 | Bristol-Myers Squibb Company | process to produce 2', 3'-dideoxynucleosides |
| JPH01100191A (ja) * | 1987-10-13 | 1989-04-18 | Sanyo Kokusaku Pulp Co Ltd | ２′，３′−ジデオキシシチジン類の製造方法 |
| SE8704298D0 (sv) * | 1987-11-03 | 1987-11-03 | Astra Ab | Compounds for use in therapy |
| US4997926A (en) * | 1987-11-18 | 1991-03-05 | Scripps Clinic And Research Foundation | Deaminase-stable anti-retroviral 2-halo-2',3'-dideoxy |
| JPH07103149B2 (ja) * | 1987-11-30 | 1995-11-08 | ヤマサ醤油株式会社 | シトシン誘導体の製造法 |
| JPH02152976A (ja) * | 1988-05-06 | 1990-06-12 | Bristol Myers Co | ２´，３´―ジデヒドロ―２´，３´―ジデオキシヌクレオシドのプロドラッグ |
| SE8802687D0 (sv) * | 1988-07-20 | 1988-07-20 | Astra Ab | Nucleoside derivatives |
| JPH0269476A (ja) * | 1988-09-06 | 1990-03-08 | Kohjin Co Ltd | ピリミジン誘導体の製法 |
| DD293498A5 (de) * | 1989-07-20 | 1991-09-05 | Zi Fuer Molekularbiologie Der Adw,De | Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier |
| US5128458A (en) * | 1990-04-20 | 1992-07-07 | Southern Research Institute | 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents |
| US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
| IL100965A (en) * | 1991-02-22 | 1999-12-31 | Univ Emory | 2-Hydroxymethyl-5-(5-fluorocytosin-l-yl)-1,3-oxathiolane its resolution and pharmaceutical compositions containing it |
| ZA923641B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| EP0640091A4 (en) * | 1992-05-13 | 1995-07-26 | Ribozyme Pharm Inc | SYNTHESIS OF NUCLEOTIDE MONOMERS. |
| DE4224737A1 (de) * | 1992-07-27 | 1994-02-03 | Herbert Prof Dr Schott | Neue Cytosinnucleosidanaloga, Verfahren zu ihrer Herstellung und ihre Verwendung |
| HU214980B (hu) * | 1992-09-01 | 1998-08-28 | Eli Lilly And Co. | Eljárás nukleozidok anomerizálására |
| GB9226927D0 (en) * | 1992-12-24 | 1993-02-17 | Iaf Biochem Int | Dideoxy nucleoside analogues |
-
1993
- 1993-07-28 US US08/098,650 patent/US5627160A/en not_active Expired - Lifetime
-
1994
- 1994-05-23 PT PT94919207T patent/PT707481E/pt unknown
- 1994-05-23 DE DE69425574T patent/DE69425574T2/de not_active Expired - Lifetime
- 1994-05-23 KR KR1019950705353A patent/KR100279953B1/ko not_active Expired - Lifetime
- 1994-05-23 JP JP7500872A patent/JPH08510747A/ja active Pending
- 1994-05-23 AT AT94919207T patent/ATE195423T1/de not_active IP Right Cessation
- 1994-05-23 CA CA002163520A patent/CA2163520C/en not_active Expired - Fee Related
- 1994-05-23 DK DK94919207T patent/DK0707481T3/da active
- 1994-05-23 EP EP94919207A patent/EP0707481B1/en not_active Expired - Lifetime
- 1994-05-23 WO PCT/US1994/005790 patent/WO1994027616A1/en not_active Ceased
- 1994-05-23 ES ES94919207T patent/ES2150993T3/es not_active Expired - Lifetime
- 1994-05-24 CN CN94106188A patent/CN1076021C/zh not_active Expired - Lifetime
-
2000
- 2000-09-08 GR GR20000402067T patent/GR3034379T3/el unknown
-
2004
- 2004-03-31 JP JP2004106919A patent/JP2004244422A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0707481B1 (en) | 2000-08-16 |
| DE69425574T2 (de) | 2001-01-04 |
| JPH08510747A (ja) | 1996-11-12 |
| CN1076021C (zh) | 2001-12-12 |
| US5627160A (en) | 1997-05-06 |
| PT707481E (pt) | 2001-02-28 |
| CA2163520C (en) | 2006-01-10 |
| JP2004244422A (ja) | 2004-09-02 |
| HK1013257A1 (en) | 1999-10-22 |
| CA2163520A1 (en) | 1994-12-08 |
| KR100279953B1 (ko) | 2001-02-01 |
| EP0707481A1 (en) | 1996-04-24 |
| EP0707481A4 (el) | 1996-05-29 |
| DE69425574D1 (en) | 2000-09-21 |
| AU693795B2 (en) | 1998-07-09 |
| CN1100303A (zh) | 1995-03-22 |
| DK0707481T3 (da) | 2000-10-30 |
| ES2150993T3 (es) | 2000-12-16 |
| WO1994027616A1 (en) | 1994-12-08 |
| ATE195423T1 (de) | 2000-09-15 |
| AU7043094A (en) | 1994-12-20 |
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