GR3017778T3 - Immunogenic complexes, in particular iscoms. - Google Patents

Immunogenic complexes, in particular iscoms.

Info

Publication number: GR3017778T3
Authority: GR; Greece
Prior art keywords: pct; iscoms; immunogenic; quil; fractions
Prior art date: 1990-10-23

Application number

GR950402880T

Other languages

English (en)

Inventor

Gideon Frank Anne Kersten

Arjen Spiekstra

Gerrit Van De Werken

Eduard Coen Beuvery

Original Assignee

Nederlanden Staat

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-23

Filing date

1995-10-18

Publication date

1996-01-31

1995-10-18 Application filed by Nederlanden Staat filed Critical Nederlanden Staat

1996-01-31 Publication of GR3017778T3 publication Critical patent/GR3017778T3/el

Links

230000002163 immunogen Effects 0.000 title abstract 6
UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 abstract 3
239000001397 quillaja saponaria molina bark Substances 0.000 abstract 3
229930182490 saponin Natural products 0.000 abstract 3
150000007949 saponins Chemical class 0.000 abstract 3
229930182558 Sterol Natural products 0.000 abstract 1
239000000427 antigen Substances 0.000 abstract 1
230000000890 antigenic effect Effects 0.000 abstract 1
102000036639 antigens Human genes 0.000 abstract 1
108091007433 antigens Proteins 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1
238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 1
230000008105 immune reaction Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
150000003432 sterols Chemical class 0.000 abstract 1
235000003702 sterols Nutrition 0.000 abstract 1
229960005486 vaccine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Microbiology (AREA)
Mycology (AREA)
Biotechnology (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

GR950402880T 1990-10-23 1995-10-18 Immunogenic complexes, in particular iscoms. GR3017778T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL9002314A NL9002314A (nl)	1990-10-23	1990-10-23	Immunogene complexen, in het bijzonder iscoms.
PCT/NL1991/000211 WO1992006710A1 (en)	1990-10-23	1991-10-23	Immunogenic complexes, in particular iscoms

Publications (1)

Publication Number	Publication Date
GR3017778T3 true GR3017778T3 (en)	1996-01-31

Family

ID=19857870

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR950402880T GR3017778T3 (en)	1990-10-23	1995-10-18	Immunogenic complexes, in particular iscoms.

Country Status (10)

Country	Link
US (1)	US5620690A (el)
EP (1)	EP0555276B1 (el)
AT (1)	ATE127024T1 (el)
CA (1)	CA2094600C (el)
DE (1)	DE69112634T2 (el)
DK (1)	DK0555276T3 (el)
ES (1)	ES2075964T3 (el)
GR (1)	GR3017778T3 (el)
NL (1)	NL9002314A (el)
WO (1)	WO1992006710A1 (el)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU677977B2 (en) *	1992-10-30	1997-05-15	Seed Capital Investments (Sci) B.V.	Cultured cells of Quillaja sp.
NL9301690A (nl) *	1993-08-12	1995-04-18	Seed Capital Investments	Verbindingen met adjuvans-activiteit.
AU1077795A (en) *	1993-09-30	1995-04-18	Seed Capital Investments (Sci) B.V.	Compounds with adjuvant activity
AUPM500494A0 (en) *	1994-04-12	1994-05-05	Minister For Agriculture & Rural Affairs For The State Of New South Wales, The	Composition for use in increasing mucosal immunity
AUPM873294A0 (en) *	1994-10-12	1994-11-03	Csl Limited	Saponin preparations and use thereof in iscoms
GB9620795D0 (en) *	1996-10-05	1996-11-20	Smithkline Beecham Plc	Vaccines
UA56132C2 (uk) *	1995-04-25	2003-05-15	Смітклайн Бічем Байолоджікалс С.А.	Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
SE9600648D0 (sv) *	1996-02-21	1996-02-21	Bror Morein	Receptorbimdande enhet
RU2127605C1 (ru) *	1996-05-22	1999-03-20	Юрий Леонидович Криворутченко	Способ стимулирования гуморального и клеточного иммунного ответа на целевой антиген
AUPO517897A0 (en) *	1997-02-19	1997-04-11	Csl Limited	Chelating immunostimulating complexes
ATE435661T1 (de) *	1997-08-29	2009-07-15	Antigenics Inc	Adjuvant qs-21 enthaltende zusammensetzungen mit polysorbate oder cyclodextrin als hilfsmittel
GB9817052D0 (en)	1998-08-05	1998-09-30	Smithkline Beecham Biolog	Vaccine
ATE409495T1 (de)	2001-04-04	2008-10-15	Nordic Vaccine Technology As	Polynukleotide-bindende komplexe die sterolen und saponine enthalten
US7713942B2 (en)	2001-04-04	2010-05-11	Nordic Vaccine Technology A/S	Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides
SE0202110D0 (sv)	2002-07-05	2002-07-05	Isconova Ab	Iscom preparation and use thereof
DE60330257D1 (de) *	2002-10-02	2010-01-07	Nordic Vaccine Technology As	Zusammensetzung zur impfung
SE0300795D0 (sv)	2003-03-24	2003-03-24	Isconova Ab	Composition comprising iscom particles and live micro-organisms
SE0301998D0 (sv)	2003-07-07	2003-07-07	Isconova Ab	Quil A fraction with low toxicity and use thereof
EP1838341B1 (en)	2005-01-20	2013-08-14	Isconova AB	Vaccine composition comprising a fibronectin binding protein or a fibronectin binding peptide
CN101160527B (zh) *	2005-04-14	2013-04-03	松下电器产业株式会社	血红蛋白衍生物的测定方法、该法中使用的试剂组合物、测定试剂盒、分析设备以及分析系统
EP2387414A1 (en)	2009-01-13	2011-11-23	Transgene SA	Use of a saccharomyces cerevisiae mitochondrial nucleic acids fraction for immune stimulation
WO2013051994A1 (en)	2011-10-03	2013-04-11	Moreinx Ab	Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrophobic molecules in fields of medicine including cancer treatment and food related compounds
RU2730625C2 (ru)	2015-09-03	2020-08-24	Новавакс, Инк.	Вакцинные композиции, характеризующиеся улучшенной стабильностью и иммуногенностью
EP3658118B1 (en)	2017-07-24	2025-03-19	Novavax, Inc.	Methods and compositions for treating respiratory disease
CN112469436B (zh)	2018-03-19	2025-03-14	诺瓦瓦克斯股份有限公司	多价流感纳米颗粒疫苗
US10953089B1 (en)	2020-01-27	2021-03-23	Novavax, Inc.	Coronavirus vaccine formulations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8205892D0 (sv) *	1982-10-18	1982-10-18	Bror Morein	Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
SE8405493D0 (sv) *	1984-11-01	1984-11-01	Bror Morein	Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
ATE71303T1 (de) *	1986-01-14	1992-01-15	Nederlanden Staat	Verfahren zur herstellung immunologischer komplexe und diese enthaltende pharmazeutische zusammensetzung.
US5057540A (en) *	1987-05-29	1991-10-15	Cambridge Biotech Corporation	Saponin adjuvant
CA1331443C (en) *	1987-05-29	1994-08-16	Charlotte A. Kensil	Saponin adjuvant
NZ230747A (en) *	1988-09-30	1992-05-26	Bror Morein	Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina
US4981684A (en) *	1989-10-24	1991-01-01	Coopers Animal Health Limited	Formation of adjuvant complexes
US5273965A (en) *	1992-07-02	1993-12-28	Cambridge Biotech Corporation	Methods for enhancing drug delivery with modified saponins

1990
- 1990-10-23 NL NL9002314A patent/NL9002314A/nl not_active Application Discontinuation
1991
- 1991-10-23 AT AT91918619T patent/ATE127024T1/de not_active IP Right Cessation
- 1991-10-23 EP EP91918619A patent/EP0555276B1/en not_active Expired - Lifetime
- 1991-10-23 WO PCT/NL1991/000211 patent/WO1992006710A1/en not_active Ceased
- 1991-10-23 DE DE69112634T patent/DE69112634T2/de not_active Expired - Lifetime
- 1991-10-23 DK DK91918619.7T patent/DK0555276T3/da active
- 1991-10-23 US US08/039,294 patent/US5620690A/en not_active Expired - Lifetime
- 1991-10-23 ES ES91918619T patent/ES2075964T3/es not_active Expired - Lifetime
- 1991-10-23 CA CA002094600A patent/CA2094600C/en not_active Expired - Lifetime
1995
- 1995-10-18 GR GR950402880T patent/GR3017778T3/el unknown

Also Published As

Publication number	Publication date
ATE127024T1 (de)	1995-09-15
DK0555276T3 (da)	1995-09-18
NL9002314A (nl)	1992-05-18
EP0555276B1 (en)	1995-08-30
ES2075964T3 (es)	1995-10-16
DE69112634D1 (de)	1995-10-05
EP0555276A1 (en)	1993-08-18
US5620690A (en)	1997-04-15
DE69112634T2 (de)	1996-02-08
CA2094600A1 (en)	1992-04-24
WO1992006710A1 (en)	1992-04-30
CA2094600C (en)	1998-12-08

Publication	Publication Date	Title
GR3017778T3 (en)	1996-01-31	Immunogenic complexes, in particular iscoms.
EP0109942A3 (en)	1985-08-14	Immunogenic protein or peptide complex, method of producing said complex and the use thereof as an immune stimulant and as a vaccine
HU9500571D0 (en)	1995-04-28	Retro-, inverso-, and retro-inverso synthetic peptide analogues
AU1934088A (en)	1988-12-21	Saponin adjuvant
MY134811A (en)	2007-12-31	A vaccine composition comprising an antigen, a saponin and a sterol
ES8203226A1 (es)	1982-04-16	Procedimiento de preparar complejos vacunantes por reaccion de arn ribonosales y de antigenos especificos.
MY103182A (en)	1993-05-29	Vaccines against acquired immune deficiency syndrome.
HUT67055A (en)	1995-01-30	Vaccine compositions containing liposomes
CA2185470A1 (en)	1995-09-21	Compositions and methods for vaccines comprising .alpha.-galactosyl epitopes
AU5646101A (en)	2001-10-08	Immunotherapeutic methods and compositions
GR3029774T3 (en)	1999-06-30	Method of preparing a radioactive rhenium complex solution.
IL97709A0 (en)	1992-06-21	Peptides and pharmaceutical compositions for treating multiple sclerosis containing the same
HUT72923A (en)	1996-06-28	Immunogenic formulation of ospc antigen vaccines for the prevention and treatment of lyme disease and recombinant methods for the preparation of such antigens
ES2114064T3 (es)	1998-05-16	Inmunoanalisis para la deteccion de colageno o fragmentos de colageno.
AU6078399A (en)	2000-04-17	Ligand presenting assembly (lpa), method of preparation and uses thereof
IL76271A0 (en)	1986-01-31	Cross-reactive and protective epitopes of circumsporozoite proteins
IL106407A0 (en)	1993-11-15	Antigens,vaccines containing them and their preparation
EP1020516A3 (en)	2000-10-11	Leptospira vaccine antigens for the prevention of leptospirosis
DE69615537D1 (en)	2001-10-31	Helicobacter pylori antigen
WO1990015132A3 (en)	1991-01-24	Cloned treponema hyodysenteriae endoflagellar antigen
MX9710523A (es)	1998-09-30	Vacunas contra hepatitis c.