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GR20010100397A - Μεθοδος παρασκευης της σιταλοπραμης. - Google Patents

Μεθοδος παρασκευης της σιταλοπραμης.

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Publication number
GR20010100397A
GR20010100397A GR20010100397A GR2001100397A GR20010100397A GR 20010100397 A GR20010100397 A GR 20010100397A GR 20010100397 A GR20010100397 A GR 20010100397A GR 2001100397 A GR2001100397 A GR 2001100397A GR 20010100397 A GR20010100397 A GR 20010100397A
Authority
GR
Greece
Prior art keywords
formula
citalopram
compound
preparation
halo
Prior art date
Application number
GR20010100397A
Other languages
English (en)
Other versions
GR1004635B (el
Inventor
Ahmadian Haleh
Petersen Hans
Dancer Robert
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Priority to GR20010100397A priority Critical patent/GR1004635B/el
Publication of GR20010100397A publication Critical patent/GR20010100397A/el
Publication of GR1004635B publication Critical patent/GR1004635B/el

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ποκαλύπτεται μία μέθοδος παρασκευής της σιταλοπράμης περιλαμβάνουσα την αντίδραση 5-καρβοξυφθαλιδίου διαδοχικά με ένα αντιδραστήριο Grignard του 4-αλογονο-φθοροφαινυλίου και ένα αντιδραστήριο Grignard της 3-αλογονο-Ν,Ν-διμεθυλ-προπυλ-αμίνης και εν συνεχεία την πραγματοποίηση κλεισίματος δακτυλίου της προκυπτούσης ενώσεως Τύπου ΧΙ προς μία ένωση Τύπου IV ακολουθούμενη από μετατροπή της ενώσεως Τύπου IV σε σιταλοπράμη. Αποκαλύπτονται επίσης μέθοδοι για την παρασκευή και τη μετατροπή της ενώσεως Τύπου IV. ΰ
GR20010100397A 2001-08-14 2001-08-14 Μεθοδοσαπαρασκευησατησασιταλοπραμης@αα GR1004635B (el)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR20010100397A GR1004635B (el) 2001-08-14 2001-08-14 Μεθοδοσαπαρασκευησατησασιταλοπραμης@αα

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20010100397A GR1004635B (el) 2001-08-14 2001-08-14 Μεθοδοσαπαρασκευησατησασιταλοπραμης@αα

Publications (2)

Publication Number Publication Date
GR20010100397A true GR20010100397A (el) 2002-05-24
GR1004635B GR1004635B (el) 2004-07-14

Family

ID=10944802

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20010100397A GR1004635B (el) 2001-08-14 2001-08-14 Μεθοδοσαπαρασκευησατησασιταλοπραμης@αα

Country Status (1)

Country Link
GR (1) GR1004635B (el)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998019513A2 (en) * 1997-07-08 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
WO2000044738A1 (en) * 1999-01-29 2000-08-03 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998019513A2 (en) * 1997-07-08 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
WO2000044738A1 (en) * 1999-01-29 2000-08-03 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide

Also Published As

Publication number Publication date
GR1004635B (el) 2004-07-14

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