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GEP20166457B - Low-oil pharmaceutical emulsion compositions comprising progestogen - Google Patents

Low-oil pharmaceutical emulsion compositions comprising progestogen

Info

Publication number
GEP20166457B
GEP20166457B GEAP201112903A GEAP2011012903A GEP20166457B GE P20166457 B GEP20166457 B GE P20166457B GE AP201112903 A GEAP201112903 A GE AP201112903A GE AP2011012903 A GEAP2011012903 A GE AP2011012903A GE P20166457 B GEP20166457 B GE P20166457B
Authority
GE
Georgia
Prior art keywords
progestogen
low
emulsion compositions
pharmaceutical emulsion
oil
Prior art date
Application number
GEAP201112903A
Inventor
Laura Pickersgill
Hoiser Eva-Maria Di
Georg Achleitner
Original Assignee
Bisains Heltqea Luqsemburg Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bisains Heltqea Luqsemburg Sarl filed Critical Bisains Heltqea Luqsemburg Sarl
Publication of GEP20166457B publication Critical patent/GEP20166457B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

An invention relates to sterile applicable form of pharmaceutical composition as oil-in-water emulsion for parenteral administration comprising progesterone, triglyceride, phospholipid, aqueous medium and polyethylene glycol 15-hydroxy¬stea¬rate. The invention relates to a method for said composition preparation and application thereat therapeutic or prophylactic treatment for mam¬malian, as well.
GEAP201112903A 2010-04-26 2011-04-26 Low-oil pharmaceutical emulsion compositions comprising progestogen GEP20166457B (en)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US32796310P 2010-04-26 2010-04-26
US32795910P 2010-04-26 2010-04-26
US32796810P 2010-04-26 2010-04-26
EP10161034 2010-04-26
EP10161032 2010-04-26
EP10161029 2010-04-26
US201061424402P 2010-12-17 2010-12-17
US201061424407P 2010-12-17 2010-12-17
US201061424411P 2010-12-17 2010-12-17
EP10195766 2010-12-17
EP10195760 2010-12-17
EP10195764 2010-12-17

Publications (1)

Publication Number Publication Date
GEP20166457B true GEP20166457B (en) 2016-04-11

Family

ID=44001967

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP201112903A GEP20166457B (en) 2010-04-26 2011-04-26 Low-oil pharmaceutical emulsion compositions comprising progestogen

Country Status (22)

Country Link
US (4) US8765149B2 (en)
EP (4) EP2563335B1 (en)
JP (1) JP5886273B2 (en)
KR (1) KR101822680B1 (en)
CN (2) CN102946865B (en)
AR (1) AR081542A1 (en)
AU (1) AU2011246527B2 (en)
BR (1) BR112012027279B1 (en)
CA (2) CA2797141C (en)
EA (1) EA022460B1 (en)
ES (4) ES2531646T3 (en)
GE (1) GEP20166457B (en)
IL (2) IL222710A (en)
MX (1) MX2012012491A (en)
MY (1) MY156858A (en)
NZ (1) NZ603176A (en)
PH (1) PH12012502120B1 (en)
PL (1) PL2563335T3 (en)
PT (1) PT2563335E (en)
SG (1) SG185025A1 (en)
TW (1) TW201138782A (en)
WO (2) WO2011134937A2 (en)

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TW201138782A (en) 2010-04-26 2011-11-16 Besins Healthcare Lu Sarl Low-oil pharmaceutical emulsion compositions comprising progestogen
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
CA2856520C (en) 2011-11-23 2021-04-06 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
EP2819650A1 (en) * 2012-02-29 2015-01-07 B. Braun Melsungen AG Hormone containing emulsion comprising krill phospholipids
TW201334808A (en) * 2012-02-29 2013-09-01 Braun Melsungen Ag Hormone containing emulsion comprising krill phospholipids
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
HK1219228A1 (en) * 2013-03-15 2017-03-31 制药创源有限公司 Intravenous emulsions of triptolide as immunomodulators and anticancer agents i
US10801070B2 (en) 2013-11-25 2020-10-13 The Broad Institute, Inc. Compositions and methods for diagnosing, evaluating and treating cancer
US11725237B2 (en) 2013-12-05 2023-08-15 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
WO2015085233A1 (en) * 2013-12-06 2015-06-11 The Broad Institute Inc. Formulations for neoplasia vaccines
AU2014368898B2 (en) 2013-12-20 2020-06-11 Dana-Farber Cancer Institute, Inc. Combination therapy with neoantigen vaccine
MX2016014281A (en) 2014-05-22 2017-02-22 Therapeuticsmd Inc Natural combination hormone replacement formulations and therapies.
BR112016029338A2 (en) 2014-07-29 2017-08-22 Therapeuticsmd Inc transdermal cream
AU2015315051B2 (en) * 2014-09-12 2018-11-08 Drexel University Toughening of anhydride cured thermosetting epoxy polymers using grafted triglycerides
US10993997B2 (en) 2014-12-19 2021-05-04 The Broad Institute, Inc. Methods for profiling the t cell repertoire
US10975442B2 (en) 2014-12-19 2021-04-13 Massachusetts Institute Of Technology Molecular biomarkers for cancer immunotherapy
AU2016240201A1 (en) * 2015-03-31 2017-05-25 Fresenius Kabi Deutschland Gmbh Emulsions for parenteral administration
PE20180670A1 (en) 2015-05-20 2018-04-19 Broad Inst Inc SHARED NEOANTIGENS
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
MX2018011705A (en) 2016-04-01 2019-06-10 Therapeuticsmd Inc Steroid hormone pharmaceutical composition.
CN106074383B (en) * 2016-07-27 2019-03-08 武汉科福新药有限责任公司 Progestational hormone medicine lipid microsphere injection and preparation method thereof
US20180207264A1 (en) * 2017-01-23 2018-07-26 Government Of The United States As Represented By The Secretary Of The Air Force Porcine immune modulation model
US11549149B2 (en) 2017-01-24 2023-01-10 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
US20220023314A1 (en) * 2018-12-10 2022-01-27 Halo Science LLC Stable formulations of anesthetics and associated dosage forms
ES2993472T3 (en) 2019-12-20 2024-12-30 Fresenius Kabi Austria Gmbh Method for manufacturing oil-in-water emulsions
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
EP3878434A1 (en) * 2020-03-12 2021-09-15 Lipoid GmbH Sunflower phospholipid composition containing phosphatidylcholine
WO2023034317A1 (en) * 2021-08-30 2023-03-09 Premier Nutrition Company, Llc Sleep-inducing beverage composition, its method of production and the method of use

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JPS60258110A (en) * 1984-06-05 1985-12-20 Daigo Eiyou Kagaku Kk Progesterone emulsified parenteral solution injectable intravenously
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Also Published As

Publication number Publication date
ES2531646T3 (en) 2015-03-18
EP2563335A2 (en) 2013-03-06
EA022460B1 (en) 2016-01-29
BR112012027279A2 (en) 2018-05-15
CN102946865A (en) 2013-02-27
EP2857042A1 (en) 2015-04-08
NZ603176A (en) 2014-05-30
EP2801353B1 (en) 2016-03-30
US20110262494A1 (en) 2011-10-27
KR101822680B1 (en) 2018-01-26
ES2576190T3 (en) 2016-07-06
EP2857042B1 (en) 2016-08-31
WO2011134944A2 (en) 2011-11-03
EP2563334A2 (en) 2013-03-06
PH12012502120A1 (en) 2013-02-04
BR112012027279B1 (en) 2020-12-29
US8476252B2 (en) 2013-07-02
SG185025A1 (en) 2012-11-29
AU2011246527B2 (en) 2016-09-15
IL222710A0 (en) 2012-12-31
US20140147474A1 (en) 2014-05-29
MX2012012491A (en) 2013-02-15
WO2011134937A3 (en) 2012-02-02
IL222738A (en) 2015-11-30
ES2606585T3 (en) 2017-03-24
CA2797141A1 (en) 2011-11-03
EP2801353A1 (en) 2014-11-12
WO2011134937A2 (en) 2011-11-03
HK1181998A1 (en) 2013-11-22
ES2514690T3 (en) 2014-10-28
CN102946864A (en) 2013-02-27
IL222710A (en) 2015-11-30
PL2563335T3 (en) 2015-05-29
US8765149B2 (en) 2014-07-01
AR081542A1 (en) 2012-10-03
PH12012502120B1 (en) 2018-01-12
IL222738A0 (en) 2012-12-31
JP2013525402A (en) 2013-06-20
JP5886273B2 (en) 2016-03-16
EP2563335B1 (en) 2014-12-17
EA201291108A1 (en) 2013-04-30
WO2011134944A3 (en) 2012-02-09
AU2011246527A1 (en) 2012-11-15
CA2797253A1 (en) 2011-11-03
CA2797253C (en) 2019-02-05
PT2563335E (en) 2015-03-31
MY156858A (en) 2016-04-15
KR20130069638A (en) 2013-06-26
EP2563334B1 (en) 2014-07-16
CN102946865B (en) 2016-06-22
TW201138782A (en) 2011-11-16
US20140335133A1 (en) 2014-11-13
US20110262495A1 (en) 2011-10-27
US9572818B2 (en) 2017-02-21
CA2797141C (en) 2018-05-15

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