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GEP20002300B - Purified Forms of Dnase, Method for Its Production, Pharmaceutical Composition and Use Thereof - Google Patents

Purified Forms of Dnase, Method for Its Production, Pharmaceutical Composition and Use Thereof

Info

Publication number
GEP20002300B
GEP20002300B GEAP19932382A GEAP1993002382A GEP20002300B GE P20002300 B GEP20002300 B GE P20002300B GE AP19932382 A GEAP19932382 A GE AP19932382A GE AP1993002382 A GEAP1993002382 A GE AP1993002382A GE P20002300 B GEP20002300 B GE P20002300B
Authority
GE
Georgia
Prior art keywords
dnase
pharmaceutical composition
production
treatment
purified forms
Prior art date
Application number
GEAP19932382A
Inventor
Mary B Sliwkowski
John Frenz
Steven J Shire
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of GEP20002300B publication Critical patent/GEP20002300B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C12Y301/21001—Deoxyribonuclease I (3.1.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

1. Technical Result Widening of assortment of the means for treatment of pulmonary distress and increase in treatment efficiency. 2. Essence Recombinant deamidated and non-deamidated Dnase forms are identified and characterized. There is provided the method for purifying these forms and pharmaceutical composition containing non-deamidated Dnase, which is disclosed within a plastic vial and is used for treatment of pulmonary distress. 3. Field of Application Medicine, therapy.
GEAP19932382A 1992-06-08 1993-05-28 Purified Forms of Dnase, Method for Its Production, Pharmaceutical Composition and Use Thereof GEP20002300B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/895,300 US5279823A (en) 1992-06-08 1992-06-08 Purified forms of DNASE

Publications (1)

Publication Number Publication Date
GEP20002300B true GEP20002300B (en) 2000-11-25

Family

ID=25404292

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP19932382A GEP20002300B (en) 1992-06-08 1993-05-28 Purified Forms of Dnase, Method for Its Production, Pharmaceutical Composition and Use Thereof

Country Status (30)

Country Link
US (4) US5279823A (en)
EP (2) EP0644932B1 (en)
JP (1) JP3383307B2 (en)
KR (2) KR100302092B1 (en)
AT (2) ATE455557T1 (en)
AU (1) AU682822B2 (en)
BG (1) BG62335B1 (en)
BR (1) BR9306670A (en)
CA (1) CA2137237C (en)
CZ (1) CZ293105B6 (en)
DE (3) DE69329200T2 (en)
DK (1) DK0644932T3 (en)
ES (1) ES2150447T3 (en)
FI (1) FI945549A0 (en)
GB (1) GB2282140B (en)
GE (1) GEP20002300B (en)
GR (1) GR3034718T3 (en)
HU (1) HU219549B (en)
IL (1) IL105724A (en)
MD (1) MD960288A (en)
NO (1) NO318644B1 (en)
NZ (1) NZ253559A (en)
PL (1) PL175873B1 (en)
PT (1) PT644932E (en)
RO (1) RO117188B1 (en)
RU (1) RU2238320C2 (en)
SK (1) SK282957B6 (en)
TJ (1) TJ396B (en)
UA (1) UA46693C2 (en)
WO (1) WO1993025670A1 (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0449968B1 (en) * 1988-12-23 1999-02-24 Genentech, Inc. Process for the preparation of human dnase
US5279823A (en) * 1992-06-08 1994-01-18 Genentech, Inc. Purified forms of DNASE
ATE268605T1 (en) 1994-03-04 2004-06-15 Genentech Inc PHARMACEUTICAL ACCEPTABLE DNASE COMPOSITION
JP3009224B2 (en) 1994-03-04 2000-02-14 ジェネンテック インコーポレイテッド Improved DNase liquid solution
US5830744A (en) * 1995-06-06 1998-11-03 Human Genome Sciences, Inc. Gene encoding human Dnase
US6251648B1 (en) 1998-04-03 2001-06-26 Human Genome Sciences, Inc. Gene encoding human Dnase
JPH09512715A (en) * 1994-05-05 1997-12-22 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド Human DNASE
US5602110A (en) * 1994-08-31 1997-02-11 Case Western Reserve University Method and composition for treating cystic fibrosis
WO1996007735A1 (en) * 1994-09-06 1996-03-14 Seiichi Tanuma Novel deoxyribonuclease
US5863563A (en) * 1994-10-20 1999-01-26 Alphagene Inc. Treatment of pulmonary conditions associated with insufficient secretion of surfactant
SK284191B6 (en) 1995-02-24 2004-10-05 Genentech, Inc. Human DNASE I variants
US6348343B2 (en) 1995-02-24 2002-02-19 Genentech, Inc. Human DNase I variants
US6482626B2 (en) * 1996-02-05 2002-11-19 Genentech, Inc. Human DNase
WO1997028266A1 (en) * 1996-02-05 1997-08-07 Genentech, Inc. Human dnase resistant to actin inhibition
US6391607B1 (en) 1996-06-14 2002-05-21 Genentech, Inc. Human DNase I hyperactive variants
ES2292682T3 (en) * 1998-05-06 2008-03-16 Genentech, Inc. PURIFICATION OF ANTIBODIES THROUGH IONIC EXCHANGE CHROMATOGRAPHY.
CA2399464C (en) * 2000-02-11 2008-10-07 Medic-Aid Limited Drug delivery apparatus
US8820316B2 (en) * 2000-02-11 2014-09-02 Respironics Respiratory Drug Delivery (Uk) Ltd Drug delivery apparatus
US6767699B2 (en) 2000-05-31 2004-07-27 Chiron Corporation Method for the quantitation of alphavirus replicon particles
MD20010375A (en) * 2001-11-19 2003-06-30 АНДРИЕВСКИ Сергей Mixer
MD2260C2 (en) * 2001-11-22 2004-03-31 АНДРИЕВСКИ Сергей Mixer
CA2496060C (en) 2002-09-11 2015-08-04 Genentech, Inc. Protein purification by ion exchange chromatography
US7067298B2 (en) 2003-03-31 2006-06-27 Ambion, Inc. Compositions and methods of using a synthetic Dnase I
US7595179B2 (en) 2004-04-19 2009-09-29 Applied Biosystems, Llc Recombinant reverse transcriptases
WO2006084111A2 (en) * 2005-02-04 2006-08-10 Glaxo Group Limited Optimization of heterologous polypeptide expression
KR100655438B1 (en) * 2005-08-25 2006-12-08 삼성전자주식회사 Magnetic memory element and its formation method
WO2007143206A2 (en) * 2006-06-02 2007-12-13 Epicentre Technologies Compositions and methods for removal of dna from a sample
DK2086642T3 (en) 2006-10-18 2014-09-29 Periness Ltd DNASE FOR TREATMENT OF SUBFERTILITY BY MEN
HRP20150282T4 (en) 2007-10-30 2018-08-10 Genentech, Inc. Antibody purification by cation exchange chromatography
WO2009123950A2 (en) * 2008-03-31 2009-10-08 The Trustees Of The University Of Pennsylvania Chimera comprising bacterial cytotoxin and methods of using the same
CA2870511C (en) 2011-04-21 2023-08-08 University Of Massachusetts Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
US9603906B2 (en) 2012-02-01 2017-03-28 Protalix Ltd. Inhalable liquid formulations of DNase I
CN103920144B (en) * 2013-01-15 2016-09-14 吴庄民 The new opplication of the deoxyribonuclease I of recombined human
TW201617360A (en) * 2014-06-25 2016-05-16 桂格 史考特 布蘭克 Methods and reagents for purification of proteins
JP6071018B2 (en) 2014-10-31 2017-02-01 Ｊｃｒファーマ株式会社 Method for producing recombinant human DNase I
US20180214576A1 (en) * 2015-07-28 2018-08-02 University Of Massachusetts Transgenic expression of dnasei in vivo delivered by an adeno-associated virus vector
US11060088B2 (en) 2016-02-12 2021-07-13 University Of Massachusetts Anti-angiogenic miRNA therapeutics for inhibiting corneal neovascularization
TWI788307B (en) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion
US11401507B2 (en) 2016-11-17 2022-08-02 Iovance Biotherapeutics, Inc. Remnant tumor infiltrating lymphocytes and methods of preparing and using the same
EP3351263A1 (en) 2017-01-20 2018-07-25 Universitätsklinikum Hamburg-Eppendorf Pharmaceutical preparation for treating or preventing tissue adhesion
EP4157309A1 (en) 2020-06-01 2023-04-05 Black Cat Bio Limited Compositions and methods for treating infections and netopathy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2801956A (en) * 1954-08-24 1957-08-06 Merck & Co Inc Process for preparing pancreatic desoxyribonuclease
US2834710A (en) * 1955-06-29 1958-05-13 Merck & Co Inc Pancreatic desoxyribonuclease penicillin composition and process of preparation
US3208908A (en) * 1961-11-16 1965-09-28 Parke Davis & Co Fibrinolysin-desoxyribonuclease for enzymatic debridement
US3663690A (en) * 1969-08-12 1972-05-16 Hoechst Co American Mucolytic composition and method of treatment of broncho-pulmonary disorders therewith
CA1059937A (en) * 1975-03-25 1979-08-07 Boen T. Khouw Isolation and purification of deoxyribonuclease
US5077211A (en) * 1988-07-06 1991-12-31 Applied Genetics, Inc. Purification and administration of dna repair enzymes
EP0449968B1 (en) * 1988-12-23 1999-02-24 Genentech, Inc. Process for the preparation of human dnase
US5279823A (en) * 1992-06-08 1994-01-18 Genentech, Inc. Purified forms of DNASE

Also Published As

Publication number Publication date
RO117188B1 (en) 2001-11-30
EP1013284A2 (en) 2000-06-28
SK149594A3 (en) 1996-01-10
FI945549L (en) 1994-11-25
BG99234A (en) 1995-07-28
PT644932E (en) 2001-02-28
SK282957B6 (en) 2003-01-09
CA2137237C (en) 2004-10-26
FI945549A7 (en) 1994-11-25
HUT70468A (en) 1995-10-30
HU219549B (en) 2001-05-28
EP0644932B1 (en) 2000-08-09
NO944752D0 (en) 1994-12-08
IL105724A (en) 1997-06-10
US6440412B1 (en) 2002-08-27
WO1993025670A1 (en) 1993-12-23
AU4398193A (en) 1994-01-04
JP3383307B2 (en) 2003-03-04
GB2282140B (en) 1996-04-17
JPH07507455A (en) 1995-08-24
RU2238320C2 (en) 2004-10-20
NO318644B1 (en) 2005-04-25
DE69329200D1 (en) 2000-09-14
DK0644932T3 (en) 2001-01-02
US20030077267A1 (en) 2003-04-24
CA2137237A1 (en) 1993-12-23
NO944752L (en) 1994-12-08
UA46693C2 (en) 2002-06-17
GB9423695D0 (en) 1995-01-11
GB2282140A (en) 1995-03-29
MD960288A (en) 1998-01-31
GR3034718T3 (en) 2001-01-31
CZ293105B6 (en) 2004-02-18
RU94046424A (en) 1997-03-10
PL175873B1 (en) 1999-02-26
KR100323357B1 (en) 2002-02-19
KR100302092B1 (en) 2001-10-22
DE69334317D1 (en) 2010-03-11
US6932965B2 (en) 2005-08-23
US5279823A (en) 1994-01-18
EP0644932A1 (en) 1995-03-29
BR9306670A (en) 1998-12-08
ATE455557T1 (en) 2010-02-15
TJ396B (en) 2004-12-29
ATE195340T1 (en) 2000-08-15
IL105724A0 (en) 1993-09-22
EP1013284A3 (en) 2000-08-30
NZ253559A (en) 1996-11-26
HU9403512D0 (en) 1995-02-28
DE4392749T1 (en) 1995-07-20
EP1013284B1 (en) 2010-01-20
US5783433A (en) 1998-07-21
AU682822B2 (en) 1997-10-23
DE69329200T2 (en) 2001-04-26
CZ303294A3 (en) 1995-06-14
BG62335B1 (en) 1999-08-31
FI945549A0 (en) 1994-11-25
ES2150447T3 (en) 2000-12-01

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