GB988008A - - Google Patents
Info
- Publication number
- GB988008A GB988008A GB988008DA GB988008A GB 988008 A GB988008 A GB 988008A GB 988008D A GB988008D A GB 988008DA GB 988008 A GB988008 A GB 988008A
- Authority
- GB
- United Kingdom
- Prior art keywords
- reacting
- prepared
- bases
- ester
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002148 esters Chemical class 0.000 abstract 5
- VYAUHXUVIULAOQ-UHFFFAOYSA-N 1,6-dihydrobenzo[b][4,1]benzothiazepine Chemical compound C1=CC=CC=2N=C3C(SCC=21)=CC=CC3 VYAUHXUVIULAOQ-UHFFFAOYSA-N 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- ZYHQGITXIJDDKC-UHFFFAOYSA-N 2-[2-(2-aminophenyl)ethyl]aniline Chemical group NC1=CC=CC=C1CCC1=CC=CC=C1N ZYHQGITXIJDDKC-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 230000000911 decarboxylating effect Effects 0.000 abstract 1
- 150000008509 dibenzothiazepines Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008016 pharmaceutical coating Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 150000003902 salicylic acid esters Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
Landscapes
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
988,008. Dibenzothiazepine derivatives. RHONE-POULENC S.A. May 15, 1962 [May 15, 1961; March 20, 1962], No. 18719/62. Heading C2C. The invention comprises bases of the general formula (wherein A represents a straight or branched chain C 2-6 alkylene group with at least 2 carbon atoms between the nucleus and the group Z, and Z represents an amino or mono- or di-alkylamino group or a 4-, 5- or 6-membered nitrogencontaining heterocyclic group attached to A by a nitrogen atom) and their non-toxic acid addition and quaternary ammonium salts, and pharmaceutical compositions containing these compounds in association with a pharmaceutical carrier or coating, and the preparation of the bases by reacting 6,11-dihydro-dibenzo- [b,e][l,4]-thiazepine (II) with a reactive ester of an alcohol Z-A-OH, or by decarboxylating an ester of the general formula by heating above 100‹ C. until evolution of carbon dioxide ceases. The bases can also be prepared by reacting a compound of formula (I), wherein Z represents the acid residue of a reactive ester, with a compound H-Z. Esters (III) are prepared by reacting (II) with phosgene and reacting the resulting carboxylic chloride (or other halide or a corresponding carboxylic ester) with an alcohol Z-A-OH. 6,11 - Dihydrodibenzo - [b,e][1,4] - thiazepine (II) is prepared by cyclizing 2-aminophenyl 2<SP>1</SP>- bromobenzyl sulphide by heating it in the presence of anhydrous potassium carbonate and copper powder. The pharmaceutical compositions, which have antidepressant and, in some cases, spasmolytic activity, may be in forms suitable for oral or parenteral administration, e.g. tablets, pills, dispersible powders, granules, emulsions, solutions, suspensions, syrups or elixirs. Acid addition salts specified include theophyllinates, theophyllinacetates, salicylates, phenolphthalinates and methylene -bis-(p-hydroxynaphthoates).
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB988008A true GB988008A (en) | 1900-01-01 |
Family
ID=1754693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB988008D Expired GB988008A (en) |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB988008A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0404359A1 (en) * | 1989-05-27 | 1990-12-27 | Pfizer Limited | Dibenzothiazepine derivatives useful as antispasmodic agents |
-
0
- GB GB988008D patent/GB988008A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0404359A1 (en) * | 1989-05-27 | 1990-12-27 | Pfizer Limited | Dibenzothiazepine derivatives useful as antispasmodic agents |
| US5071844A (en) * | 1989-05-27 | 1991-12-10 | Pfizer Inc. | 5,11-dihydrodibenzo[b,e][1,4]-thiazepines useful as gastro intestinal selective calcium antagonists |
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