GB985206A - Improvements in or relating to therapeutic iron preparation - Google Patents
Improvements in or relating to therapeutic iron preparationInfo
- Publication number
- GB985206A GB985206A GB4569061A GB4569061A GB985206A GB 985206 A GB985206 A GB 985206A GB 4569061 A GB4569061 A GB 4569061A GB 4569061 A GB4569061 A GB 4569061A GB 985206 A GB985206 A GB 985206A
- Authority
- GB
- United Kingdom
- Prior art keywords
- iron
- complex
- polyisomaltose
- hydroxide
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title abstract 12
- 229910052742 iron Inorganic materials 0.000 title abstract 6
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 239000000243 solution Substances 0.000 abstract 5
- 239000000725 suspension Substances 0.000 abstract 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 3
- 229910000288 alkali metal carbonate Inorganic materials 0.000 abstract 3
- 150000008041 alkali metal carbonates Chemical class 0.000 abstract 3
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 3
- 150000002506 iron compounds Chemical class 0.000 abstract 3
- 229920002307 Dextran Polymers 0.000 abstract 2
- 229910002588 FeOOH Inorganic materials 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000003456 ion exchange resin Substances 0.000 abstract 2
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 2
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 abstract 1
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 239000003929 acidic solution Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 239000003792 electrolyte Substances 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 239000007972 injectable composition Substances 0.000 abstract 1
- 150000002505 iron Chemical class 0.000 abstract 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A polymeric g -ferric oxide-hydroxide of formula (g -FeOOH)n is said to be formed in the preparation of a ferric hydroxide-polyisomaltose complex. An aqueous solution of an alkali metal carbonate or bicarbonate is added to an aqueous solution of polyisomaltose and an iron salt at 15-25 DEG C., to give a pH of about 2.6. Alkali metal hydroxide is then added to form a suspension of pH 11 or more, and the suspension is heated to form a solution.ALSO:A ferric hydroxide-polyisomaltose (i.e. water-soluble dextran) complex comprises 2 mols. of iron per anhydroglucose unit. The complex, which contains about 33% of iron, is made by adding to an acidic solution of polyisomaltose and a water-soluble iron compound at 15 DEG to 25 DEG C., an aqueous solution of an alkali metal carbonate or bicarbonate, subsequently adding an alkali metal hydroxide, heating the resulting suspension to form a solution and neutralizing the solution. Specified iron compounds are ferric chloride, acetate, sulphate or nitrate. The solution of the complex may be neutralized, e.g. addition of acids or ion-exchange resins. Electrolytes may be removed by further addition of ion-exchange resins or by dialysis, and the complex may be isolated by precipitation with organic solvents or by evaporation of the solution. The viscosity of the polyisomaltose may be reduced, if necessary, by heating and subsequently cooling the acids olution of iron compound and polyisomaltose. Preferably, alkali metal carbonate or bicarbonate is added to give a pH of about 2.6, and alkali metal hydroxide to give a suspension of pH not less than 11. The suspension may be heated to e.g. 90-100 DEG C. The polysaccharide is said to complex with a polymeric g -ferric oxide-hydroxide (g -FeOOH)n (Division C1). The complex is non-colloidal, and has therapeutic properties (Division A5). Specifications 748,024, Canadian Specifications 623,411, 623,412 and U.S.A. Specification 2,885,393 are referred to.ALSO:A parenterally-injectable composition for the treatment of iron-deficiency anaemia contains an iron hydroxide-polyisomaltose (a water-soluble dextran) complex comprising 2 moles of iron per anhydroglucose unit and containing about 33% by weight of iron. Specification 748,024 is referred to.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEL40581A DE1196629B (en) | 1961-11-30 | 1961-11-30 | Process for the production of nonionic, therapeutically usable ferric hydroxide-dextran complexes |
| GB4569061A GB985206A (en) | 1961-12-20 | 1961-12-20 | Improvements in or relating to therapeutic iron preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4569061A GB985206A (en) | 1961-12-20 | 1961-12-20 | Improvements in or relating to therapeutic iron preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB985206A true GB985206A (en) | 1965-03-03 |
Family
ID=10438178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4569061A Expired GB985206A (en) | 1961-11-30 | 1961-12-20 | Improvements in or relating to therapeutic iron preparation |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB985206A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11123321B2 (en) | 2002-10-23 | 2021-09-21 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11344568B2 (en) | 2006-01-06 | 2022-05-31 | American Regent, Inc. | Methods and compositions for administration of iron |
-
1961
- 1961-12-20 GB GB4569061A patent/GB985206A/en not_active Expired
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11123321B2 (en) | 2002-10-23 | 2021-09-21 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11291645B2 (en) | 2002-10-23 | 2022-04-05 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11590097B2 (en) | 2002-10-23 | 2023-02-28 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11344568B2 (en) | 2006-01-06 | 2022-05-31 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11364260B2 (en) | 2006-01-06 | 2022-06-21 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11406656B2 (en) | 2006-01-06 | 2022-08-09 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11433091B2 (en) | 2006-01-06 | 2022-09-06 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11478502B2 (en) | 2006-01-06 | 2022-10-25 | American Regent, Inc. | Methods and compositions for administration of iron |
| US12329772B2 (en) | 2006-01-06 | 2025-06-17 | American Regent, Inc. | Methods and compositions for administration of iron |
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