GB960167A - Improvements in or relating to diagnostic compositions - Google Patents
Improvements in or relating to diagnostic compositionsInfo
- Publication number
- GB960167A GB960167A GB30938/61A GB3093861A GB960167A GB 960167 A GB960167 A GB 960167A GB 30938/61 A GB30938/61 A GB 30938/61A GB 3093861 A GB3093861 A GB 3093861A GB 960167 A GB960167 A GB 960167A
- Authority
- GB
- United Kingdom
- Prior art keywords
- composition
- glucose
- oxidation
- hydrogen peroxide
- dihydroxybenzaldazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 8
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 3
- 239000003054 catalyst Substances 0.000 abstract 3
- 239000008103 glucose Substances 0.000 abstract 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 abstract 3
- 108010015776 Glucose oxidase Proteins 0.000 abstract 2
- 239000004366 Glucose oxidase Substances 0.000 abstract 2
- 229920000159 gelatin Polymers 0.000 abstract 2
- 235000019322 gelatine Nutrition 0.000 abstract 2
- 229940116332 glucose oxidase Drugs 0.000 abstract 2
- 235000019420 glucose oxidase Nutrition 0.000 abstract 2
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 abstract 1
- 108010076119 Caseins Proteins 0.000 abstract 1
- 102000016938 Catalase Human genes 0.000 abstract 1
- 108010053835 Catalase Proteins 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 239000001828 Gelatine Substances 0.000 abstract 1
- 108010058846 Ovalbumin Proteins 0.000 abstract 1
- 102000003992 Peroxidases Human genes 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000005018 casein Substances 0.000 abstract 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 1
- 235000021240 caseins Nutrition 0.000 abstract 1
- 229920002301 cellulose acetate Polymers 0.000 abstract 1
- 229940069078 citric acid / sodium citrate Drugs 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- IQDXAJNQKSIPGB-HQSZAHFGSA-N geranyllinalool Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CCC(C)(O)C=C IQDXAJNQKSIPGB-HQSZAHFGSA-N 0.000 abstract 1
- 239000011521 glass Substances 0.000 abstract 1
- BTIJJDXEELBZFS-QDUVMHSLSA-K hemin Chemical compound CC1=C(CCC(O)=O)C(C=C2C(CCC(O)=O)=C(C)\C(N2[Fe](Cl)N23)=C\4)=N\C1=C/C2=C(C)C(C=C)=C3\C=C/1C(C)=C(C=C)C/4=N\1 BTIJJDXEELBZFS-QDUVMHSLSA-K 0.000 abstract 1
- 229940025294 hemin Drugs 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000000123 paper Substances 0.000 abstract 1
- 108040007629 peroxidase activity proteins Proteins 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000004033 plastic Substances 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 239000011684 sodium molybdate Substances 0.000 abstract 1
- 235000015393 sodium molybdate Nutrition 0.000 abstract 1
- TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 abstract 1
- 210000002700 urine Anatomy 0.000 abstract 1
- 239000002023 wood Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
- C12Q2326/30—2,2'-Azinobis (3-ethylbenzothiazoline-6-sulfonic acid), i.e. ABTS
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/206664—Ozone or peroxide
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A composition for detecting glucose in urine comprises glucose oxidase, an oxidation-catalyst, and an indicator which is oxidized by hydrogen peroxide, changes colour on oxidation and has the general formula AR-X-AR wherein Ar is a phenyl group which may have one or more hydroxy and methoxy substituents and X is the radical -(CH=CH)m-CH=(N-N)n=CH-(CH=CH)p-in which m, n and p are each each to 0 or to 1, and a catalyst for causing the oxidation of the indicator by hydrogen peroxide. The glucose oxidase converts glucose to gluoconic acid in the presence of atmospheric oxygen and at the same time forms hydrogen peroxide. Suitable indicators are 4,41-dihydroxystilbene, 4,41-dihydroxybenzaldazine, vanillinazine, 3,31,5,51-tetramethoxy-4, 41-dihydroxybenzaldazine, 3,31-dimethoxy-4,41-dihydroxystilbene, and bis-gamma(4-hydroxyphenyl)acroleinazine. Splinters, sticks or strips of wood, paper or cellulose acetate may be impregnated with the composition; or the composition may be applied to glass, metal or plastic using gelatin as adhesive. Such test pieces will change colour when moistened with a glucose-containing liquid. Suitable catalysts are peroxidase, catalase, blood, hemin, uroferriporphrin chloride, and a mixture of potassium iodide and sodium molybdate. A buffer composition, e.g. citric acid/sodium citrate may be added to the test composition in order to keep the pH of the reactants at a predetermined value. Gelatine, dog plasma, bovine albumin, egg albumin and casein may be incorporated in the compositions. Specification 808,742 is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US218868A US3233974A (en) | 1961-08-28 | 1962-08-23 | Diagnostic compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2149470A | 1970-03-20 | 1970-03-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB960167A true GB960167A (en) | 1964-06-10 |
Family
ID=21804551
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB30938/61A Expired GB960167A (en) | 1961-08-28 | 1961-08-28 | Improvements in or relating to diagnostic compositions |
| GB16914/64A Expired GB1068533A (en) | 1970-03-20 | 1964-04-23 | Improvements relating to glucose testing |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB16914/64A Expired GB1068533A (en) | 1970-03-20 | 1964-04-23 | Improvements relating to glucose testing |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US3627698A (en) |
| GB (2) | GB960167A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0247845A1 (en) * | 1986-05-30 | 1987-12-02 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Use of methine dyes for the determination of hydrogen peroxide or analytes producing same |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7208092A (en) * | 1972-06-14 | 1973-12-18 | ||
| US3926732A (en) * | 1973-02-16 | 1975-12-16 | Alfa Laval Ab | Method for assaying catalase in milk and other liquids |
| CS175782B1 (en) * | 1974-10-16 | 1977-05-31 | ||
| US4175923A (en) * | 1978-06-26 | 1979-11-27 | Friend William G | Method and apparatus for occult blood testing in the home |
| US4247297A (en) * | 1979-02-23 | 1981-01-27 | Miles Laboratories, Inc. | Test means and method for interference resistant determination of oxidizing substances |
| US4344439A (en) * | 1980-10-20 | 1982-08-17 | Ulrico Jacobellis | Catheter for use in localizing the origin of idiopathic microscopic hematuria |
| US4956300A (en) * | 1982-01-05 | 1990-09-11 | Helena Laboratories Corporation | Aid for determining the presence of occult blood, method of making the aid, and method of using the aid |
| US5702913A (en) * | 1983-12-21 | 1997-12-30 | Helena Laboratories Corporation | Chromgen-reagent test system |
| US5273888A (en) * | 1984-01-16 | 1993-12-28 | Helena Laboratories Corporation | Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals |
| US4615982A (en) * | 1984-12-11 | 1986-10-07 | Lawrence Paul J | Fecal occult blood test |
| EP0477999A1 (en) * | 1984-12-11 | 1992-04-01 | LAWRENCE, Paul J. | Fecal occult blood test reagent and methods |
| US4818702A (en) * | 1986-06-02 | 1989-04-04 | Litmus Concepts, Inc. | Fecal occult blood test reagent |
| US5081040A (en) * | 1987-06-29 | 1992-01-14 | Helena Laboratories Corporation | Composition and kit for testing for occult blood in human and animal excretions, fluids, or tissue matrixes |
| US5183751A (en) * | 1988-04-20 | 1993-02-02 | Maes Roland F | Stabilization of peroxidase solutions by para-amino-salicyclic acid |
| US5196167A (en) * | 1989-04-04 | 1993-03-23 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
| US5217874A (en) * | 1989-04-04 | 1993-06-08 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
| GB9027131D0 (en) * | 1990-12-14 | 1991-02-06 | Rice Evans Catherine | Diagnostic test |
| US6063631A (en) * | 1997-05-21 | 2000-05-16 | 3M Innovative Properties Company | Sterilization indicator |
| US6238623B1 (en) | 1997-05-21 | 2001-05-29 | 3M Innovative Properties Company | Labels and tracking systems for sterilization procedures |
| US6287518B1 (en) | 1997-06-25 | 2001-09-11 | 3M Innovative Properties Company | Sterilization monitors |
| US9034593B2 (en) | 2010-11-22 | 2015-05-19 | Kimberly-Clark Worldwide, Inc. | Vaginal indicator to detect biomarkers of good health |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3183173A (en) * | 1963-06-10 | 1965-05-11 | Miles Lab | Test composition for detecting hydrogen peroxide |
-
1961
- 1961-08-28 GB GB30938/61A patent/GB960167A/en not_active Expired
-
1964
- 1964-04-23 GB GB16914/64A patent/GB1068533A/en not_active Expired
-
1970
- 1970-03-20 US US21494A patent/US3627698A/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0247845A1 (en) * | 1986-05-30 | 1987-12-02 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Use of methine dyes for the determination of hydrogen peroxide or analytes producing same |
Also Published As
| Publication number | Publication date |
|---|---|
| US3627698A (en) | 1971-12-14 |
| GB1068533A (en) | 1967-05-10 |
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