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GB958574A - Clostridium perfringens ª‰-toxoid vaccines - Google Patents

Clostridium perfringens ª‰-toxoid vaccines

Info

Publication number
GB958574A
GB958574A GB3974159A GB3974159A GB958574A GB 958574 A GB958574 A GB 958574A GB 3974159 A GB3974159 A GB 3974159A GB 3974159 A GB3974159 A GB 3974159A GB 958574 A GB958574 A GB 958574A
Authority
GB
United Kingdom
Prior art keywords
formaldehyde
clostridium perfringens
toxoid
toxoid vaccines
welchii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3974159A
Inventor
Max Sterne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB3974159A priority Critical patent/GB958574A/en
Priority to ES0262655A priority patent/ES262655A1/en
Publication of GB958574A publication Critical patent/GB958574A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to a stable vaccine containing Clostridium perfringens (Cl. welchii) b -toxoid from which most or all of the free formaldehyde has been removed. The formaldehyde is removed by (a) dialysis especially against polyethylene glycol; (b) ultra-filtration using membranes which retain proteins but allow molecules of smaller molecular weight to pass; or (c) addition of sodium metabisulphite or other pharmaceutically acceptable reagent capable of reacting with formaldehyde, provided that the aldehyde-reaction products are suitable for injection and harmless to the immunizing agent.
GB3974159A 1959-11-23 1959-11-23 Clostridium perfringens ª‰-toxoid vaccines Expired GB958574A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB3974159A GB958574A (en) 1959-11-23 1959-11-23 Clostridium perfringens ª‰-toxoid vaccines
ES0262655A ES262655A1 (en) 1959-11-23 1960-11-22 Clostridium perfringens -toxoid vaccines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3974159A GB958574A (en) 1959-11-23 1959-11-23 Clostridium perfringens ª‰-toxoid vaccines

Publications (1)

Publication Number Publication Date
GB958574A true GB958574A (en) 1964-05-21

Family

ID=10411216

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3974159A Expired GB958574A (en) 1959-11-23 1959-11-23 Clostridium perfringens ª‰-toxoid vaccines

Country Status (2)

Country Link
ES (1) ES262655A1 (en)
GB (1) GB958574A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4264588A (en) * 1979-05-10 1981-04-28 The Charles River Breeding Laboratories, Inc. Vaccine for Clostridium perfringens type E enterotoxemia of rabbits
US4292307A (en) * 1977-09-30 1981-09-29 Zemlyakova Valentina P Vaccine and method for prophylaxis and treatment of clostridioses of animals and poultry
EP0892054A1 (en) * 1997-06-20 1999-01-20 Akzo Nobel N.V. Clostridium perfringens vaccine
CN107789622A (en) * 2017-10-18 2018-03-13 山东农业大学 A kind of calf enterotoxemia C.perfringens β2The preparation method of toxin toxoid vaccine

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292307A (en) * 1977-09-30 1981-09-29 Zemlyakova Valentina P Vaccine and method for prophylaxis and treatment of clostridioses of animals and poultry
US4264588A (en) * 1979-05-10 1981-04-28 The Charles River Breeding Laboratories, Inc. Vaccine for Clostridium perfringens type E enterotoxemia of rabbits
EP0892054A1 (en) * 1997-06-20 1999-01-20 Akzo Nobel N.V. Clostridium perfringens vaccine
US6610300B1 (en) 1997-06-20 2003-08-26 Akzo Nobel N.V. Clostridium perfringens vaccine
CN107789622A (en) * 2017-10-18 2018-03-13 山东农业大学 A kind of calf enterotoxemia C.perfringens β2The preparation method of toxin toxoid vaccine

Also Published As

Publication number Publication date
ES262655A1 (en) 1961-03-01

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