GB958186A - Salicylamide derivatives - Google Patents
Salicylamide derivativesInfo
- Publication number
- GB958186A GB958186A GB4440362A GB4440362A GB958186A GB 958186 A GB958186 A GB 958186A GB 4440362 A GB4440362 A GB 4440362A GB 4440362 A GB4440362 A GB 4440362A GB 958186 A GB958186 A GB 958186A
- Authority
- GB
- United Kingdom
- Prior art keywords
- salicylamide
- salicylamide derivatives
- derivatives
- diethylaminobutyl
- acylates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical class NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000001805 chlorine compounds Chemical class 0.000 abstract 1
- 150000001860 citric acid derivatives Chemical class 0.000 abstract 1
- JILXUIANNUALRZ-UHFFFAOYSA-N n',n'-diethylbutane-1,4-diamine Chemical compound CCN(CC)CCCCN JILXUIANNUALRZ-UHFFFAOYSA-N 0.000 abstract 1
- YDHWQDXJNDFHJI-UHFFFAOYSA-N n-[4-(diethylamino)butyl]-2-hydroxybenzamide Chemical compound CCN(CC)CCCCNC(=O)C1=CC=CC=C1O YDHWQDXJNDFHJI-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention comprises N-(4-diethylaminobutyl)-salicylamide and O-acylates thereof, and their citrates. They may be prepared from the acid chlorides and 4-diethylamino-butylamine. Examples are given. The amides of the invention, which are analgesics, may be made up into pharmaceutical compositions, e.g. pills, suppositories or injectable solutions, with suitable carriers. German Specification 1,098,001 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR67007532 | 1962-10-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB958186A true GB958186A (en) | 1964-05-21 |
Family
ID=9694012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4440362A Expired GB958186A (en) | 1962-10-02 | 1962-11-23 | Salicylamide derivatives |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH399486A (en) |
| DE (1) | DE1179556B (en) |
| GB (1) | GB958186A (en) |
| LU (1) | LU42765A1 (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2038251A4 (en) * | 2006-07-09 | 2010-04-21 | Techfields Biochem Co Ltd | WATER-SOLUBLE PRODRUGS WITH POSITIVE ASPIRIN LOAD |
| AU2013206215A1 (en) * | 2006-07-09 | 2013-06-27 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aspirin |
| CN103922946A (en) * | 2006-07-09 | 2014-07-16 | 于崇曦 | Positively-charged water-soluble prodrugs of aspirin |
| CN104276962A (en) * | 2013-07-08 | 2015-01-14 | 浙江越甲药业有限公司 | Aspirin derivative and its composition and use |
| CN105439877A (en) * | 2006-07-26 | 2016-03-30 | 于崇曦 | Positively charged water-soluble prodrug of diflunisal and related compound |
| JP2016047841A (en) * | 2015-12-03 | 2016-04-07 | テックフィールズ バイオケム カンパニー リミテッド | Positively-charged-water soluble prodrug of aspirin |
| US9371284B2 (en) | 2007-06-04 | 2016-06-21 | Techfields Pharma Co., Ltd. | Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses |
| JP2017119704A (en) * | 2017-02-21 | 2017-07-06 | テックフィールズ バイオケム カンパニー リミテッド | Positively-charged-water soluble prodrug of aspirin |
| US9872846B2 (en) | 2006-07-09 | 2018-01-23 | Techfields Pharma Co., Ltd. | High penetration compositions and uses thereof |
| JP2018058899A (en) * | 2018-01-04 | 2018-04-12 | テックフィールズ バイオケム カンパニー リミテッド | Positively charged water-soluble prodrug of aspirin |
| AU2016219617B2 (en) * | 2006-07-09 | 2018-05-17 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aspirin |
| US11135153B2 (en) | 2006-07-09 | 2021-10-05 | Techfields Pharma Co., Ltd. | High penetration composition and uses thereof |
| US11541029B2 (en) | 2008-12-04 | 2023-01-03 | Techfields Pharma Co., Ltd. | High penetration compositions and their applications |
| WO2023134732A1 (en) * | 2022-01-17 | 2023-07-20 | Techfields Pharma Co., Ltd. | Prevention or treatment of cardiovascular diseases with high penetration prodrugs of aspirin and other nsaids |
| US11813256B2 (en) | 2012-01-18 | 2023-11-14 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical compositon thereof for treatment of pulmonary conditions |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4256664A (en) * | 1973-03-12 | 1981-03-17 | Colgate-Palmolive Company | Substantive sunscreen agents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2810718A (en) * | 1953-07-02 | 1957-10-22 | Abbott Lab | Basic salicylamides |
| DE1098001B (en) * | 1957-09-12 | 1961-01-26 | Knoll Ag | Process for the preparation of N- (Diaethylaminoalkyl) -salicylamiden |
-
1962
- 1962-11-16 CH CH1342162A patent/CH399486A/en unknown
- 1962-11-23 GB GB4440362A patent/GB958186A/en not_active Expired
- 1962-11-26 LU LU42765D patent/LU42765A1/xx unknown
- 1962-12-31 DE DE1962S0083125 patent/DE1179556B/en active Pending
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013206215C9 (en) * | 2006-07-09 | 2018-03-08 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aspirin |
| AU2006346195B2 (en) * | 2006-07-09 | 2013-03-07 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aspirin |
| AU2013206215A1 (en) * | 2006-07-09 | 2013-06-27 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aspirin |
| EP2610242A1 (en) * | 2006-07-09 | 2013-07-03 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aspirin |
| CN101484415B (en) * | 2006-07-09 | 2013-08-14 | 于崇曦 | Positively charged water-soluble aspirin prodrugs |
| CN103922946A (en) * | 2006-07-09 | 2014-07-16 | 于崇曦 | Positively-charged water-soluble prodrugs of aspirin |
| US11135153B2 (en) | 2006-07-09 | 2021-10-05 | Techfields Pharma Co., Ltd. | High penetration composition and uses thereof |
| EP2038251A4 (en) * | 2006-07-09 | 2010-04-21 | Techfields Biochem Co Ltd | WATER-SOLUBLE PRODRUGS WITH POSITIVE ASPIRIN LOAD |
| AU2016219617B2 (en) * | 2006-07-09 | 2018-05-17 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aspirin |
| US9872846B2 (en) | 2006-07-09 | 2018-01-23 | Techfields Pharma Co., Ltd. | High penetration compositions and uses thereof |
| CN105439877A (en) * | 2006-07-26 | 2016-03-30 | 于崇曦 | Positively charged water-soluble prodrug of diflunisal and related compound |
| CN105439877B (en) * | 2006-07-26 | 2019-07-23 | 于崇曦 | The prodrug of positively charged water-soluble Diflunisal and related compound |
| US10233198B2 (en) | 2007-06-04 | 2019-03-19 | Techfields Pharma Co., Ltd. | Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses |
| US9371284B2 (en) | 2007-06-04 | 2016-06-21 | Techfields Pharma Co., Ltd. | Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses |
| US11541029B2 (en) | 2008-12-04 | 2023-01-03 | Techfields Pharma Co., Ltd. | High penetration compositions and their applications |
| US11813256B2 (en) | 2012-01-18 | 2023-11-14 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical compositon thereof for treatment of pulmonary conditions |
| US11857545B2 (en) | 2012-01-18 | 2024-01-02 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions |
| CN104276962B (en) * | 2013-07-08 | 2019-04-12 | 浙江越甲药业有限公司 | A kind of aspirin derivatives and combinations thereof and application |
| CN104276962A (en) * | 2013-07-08 | 2015-01-14 | 浙江越甲药业有限公司 | Aspirin derivative and its composition and use |
| JP2016047841A (en) * | 2015-12-03 | 2016-04-07 | テックフィールズ バイオケム カンパニー リミテッド | Positively-charged-water soluble prodrug of aspirin |
| JP2017119704A (en) * | 2017-02-21 | 2017-07-06 | テックフィールズ バイオケム カンパニー リミテッド | Positively-charged-water soluble prodrug of aspirin |
| JP2018058899A (en) * | 2018-01-04 | 2018-04-12 | テックフィールズ バイオケム カンパニー リミテッド | Positively charged water-soluble prodrug of aspirin |
| WO2023134732A1 (en) * | 2022-01-17 | 2023-07-20 | Techfields Pharma Co., Ltd. | Prevention or treatment of cardiovascular diseases with high penetration prodrugs of aspirin and other nsaids |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1179556B (en) | 1964-10-15 |
| LU42765A1 (en) | 1963-01-26 |
| CH399486A (en) | 1965-09-30 |
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