GB938828A - Improvements in or relating to pharmaceutical capsules comprising radioactive materials - Google Patents
Improvements in or relating to pharmaceutical capsules comprising radioactive materialsInfo
- Publication number
- GB938828A GB938828A GB33882/61A GB3388261A GB938828A GB 938828 A GB938828 A GB 938828A GB 33882/61 A GB33882/61 A GB 33882/61A GB 3388261 A GB3388261 A GB 3388261A GB 938828 A GB938828 A GB 938828A
- Authority
- GB
- United Kingdom
- Prior art keywords
- vehicle
- oil
- radioactive
- pharmaceutical capsules
- incorporated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002775 capsule Substances 0.000 title abstract 2
- 239000012857 radioactive material Substances 0.000 title 1
- 239000003981 vehicle Substances 0.000 abstract 4
- 239000003921 oil Substances 0.000 abstract 3
- 235000019198 oils Nutrition 0.000 abstract 3
- 230000002285 radioactive effect Effects 0.000 abstract 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 abstract 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 abstract 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 abstract 1
- 240000004385 Centaurea cyanus Species 0.000 abstract 1
- 239000001828 Gelatine Substances 0.000 abstract 1
- 239000005642 Oleic acid Substances 0.000 abstract 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 abstract 1
- 235000019485 Safflower oil Nutrition 0.000 abstract 1
- 240000006474 Theobroma bicolor Species 0.000 abstract 1
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 abstract 1
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 abstract 1
- 235000013871 bee wax Nutrition 0.000 abstract 1
- 239000012166 beeswax Substances 0.000 abstract 1
- 229940092738 beeswax Drugs 0.000 abstract 1
- 229960000541 cetyl alcohol Drugs 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 229940075507 glyceryl monostearate Drugs 0.000 abstract 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000155 melt Substances 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 229920000609 methyl cellulose Polymers 0.000 abstract 1
- 239000001923 methylcellulose Substances 0.000 abstract 1
- 235000010981 methylcellulose Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 abstract 1
- 235000021313 oleic acid Nutrition 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- -1 radioactive Substances 0.000 abstract 1
- 235000005713 safflower oil Nutrition 0.000 abstract 1
- 239000003813 safflower oil Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000012177 spermaceti Substances 0.000 abstract 1
- 229940084106 spermaceti Drugs 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 229920001169 thermoplastic Polymers 0.000 abstract 1
- 239000004416 thermosoftening plastic Substances 0.000 abstract 1
- 229940035722 triiodothyronine Drugs 0.000 abstract 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 abstract 1
- 229940117972 triolein Drugs 0.000 abstract 1
- 239000001993 wax Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1262—Capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Pharmaceutical capsules composed of a water-soluble, thermoplastic, non-toxic material (e.g. gelatine, methyl cellulose or P.V.A.) contain a vehicle which melts at about 37 DEG C. and has incorporated therein a radioactive compound. The vehicle is a mixture of a wax, e.g. carbowax, spermaceti, beeswax, glyceryl monostearate or cetyl alcohol and an "oil" e.g. theobroma oil or a hydrogenated or partially hydrogenated vegetable oil, the proportions of each being chosen so that the vehicle has the desired melting point. The radioactive compound may be an oil, e.g. glyceryl trioleate, corn and safflower oils, or oleic acid tagged with I131 or a solid, e.g. radioactive, iodine or triiodothyronine, which may be incorporated into the vehicle as such or in suspension or emulsion form. Specification 767,073 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60312A US3159545A (en) | 1960-10-04 | 1960-10-04 | Radioactive capsules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB938828A true GB938828A (en) | 1963-10-09 |
Family
ID=22028701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB33882/61A Expired GB938828A (en) | 1960-10-04 | 1961-09-21 | Improvements in or relating to pharmaceutical capsules comprising radioactive materials |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3159545A (en) |
| BE (1) | BE608721A (en) |
| FR (1) | FR1712M (en) |
| GB (1) | GB938828A (en) |
| NL (1) | NL269886A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE29474E (en) * | 1966-06-02 | 1977-11-15 | Pharmacia Ab | Method for the determination of proteins and polypeptides |
| EP0001822A3 (en) * | 1977-11-03 | 1979-08-22 | Hoechst Aktiengesellschaft | Process for the manufacture of pharmaceutical preparations |
| DE3115053A1 (en) * | 1980-04-14 | 1982-02-18 | E.R. Squibb & Sons, Inc., 08540 Princeton, N.J. | CAPSULES CONTAINING RADIOACTIVE CONNECTIONS AND METHOD FOR FILLING THE SAME |
| EP0974346A3 (en) * | 1998-07-23 | 2000-05-24 | Nyl Service s.r.l. | Self-sealing capsule and method of producing same |
| US8298575B2 (en) | 1998-08-05 | 2012-10-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Two-part capsule to accept pharmaceutical preparations for powder inhalers |
| US8662076B2 (en) | 2005-01-11 | 2014-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3421282A (en) * | 1963-09-28 | 1969-01-14 | Daiichi Kagaku Yakuhin Co Ltd | Method for obtaining capsules having oily drugs closed therein |
| US3474777A (en) * | 1966-02-10 | 1969-10-28 | Amp Inc | Method of administering therapeutic agents |
| NL6808619A (en) * | 1968-06-19 | 1969-12-23 | ||
| US4331654A (en) * | 1980-06-13 | 1982-05-25 | Eli Lilly And Company | Magnetically-localizable, biodegradable lipid microspheres |
| DD160448B1 (en) * | 1981-03-13 | 1987-01-14 | Adw Ddr | PROCESS FOR THE PREPARATION OF HIGH 131JOD MEDICALLY APPLICABLE PREPARATIONS |
| US4505888A (en) * | 1983-05-27 | 1985-03-19 | E. I. Du Pont De Nemours & Company | Tracer for circulation determinations |
| US4610868A (en) * | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
| US4663148A (en) * | 1984-03-21 | 1987-05-05 | Alza Corporation | Dispenser comprising telescopically engaging members |
| US4716031A (en) * | 1984-03-21 | 1987-12-29 | Alza Corporation | Drug dispenser comprising a multiplicity of members acting together for successfully dispensing drug |
| US4692326A (en) * | 1984-03-21 | 1987-09-08 | Alza Corporation | Dispenser comprising inner positioned soft or hard capsule |
| US4663149A (en) * | 1984-03-21 | 1987-05-05 | Alza Corporation | Dispenser comprising inner and outer walls functioning as cooperative unit |
| FR2622110A1 (en) * | 1987-10-26 | 1989-04-28 | Marty Georges | Battery designed to utilise the radioactive power of plants for medical purposes |
| US5227165A (en) * | 1989-11-13 | 1993-07-13 | Nova Pharmaceutical Corporation | Liposphere delivery systems for local anesthetics |
| US5188837A (en) * | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
| US5221535A (en) * | 1989-11-13 | 1993-06-22 | Nova Pharmaceutical Corporation | Sustained release formulations of insect repellent |
| IE904098A1 (en) * | 1989-11-13 | 1991-05-22 | Nova Pharm Corp | Lipospheres for controlled delivery of substances |
| US5314678A (en) * | 1992-01-28 | 1994-05-24 | Mallinckrodt Medical, Inc. | Sodium iodide 131 I capsules |
| US5514869A (en) * | 1994-02-22 | 1996-05-07 | Martin, Jr.; James A. | Method for estimating the probabilities of digestive tract doses due to the passage of a solid radioactive particle |
| GB2320456B (en) * | 1996-12-18 | 2001-09-05 | Fip Holdings Ltd | Polymer processing method |
| US5993374A (en) * | 1997-06-17 | 1999-11-30 | Radiance Medical Systems, Inc. | Microcapsules for site-specific delivery |
| GB2340835B (en) | 1998-08-26 | 2003-01-15 | Pvax Ploymers Ltd | PVA-containing compositions |
| GB0005016D0 (en) * | 2000-03-01 | 2000-04-26 | Jumik Technologies Limited | PVA-Containing compositions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2780355A (en) * | 1953-11-09 | 1957-02-05 | Scherer Corp R P | Gelatin capsule containing water soluble substances |
| US2911338A (en) * | 1954-03-09 | 1959-11-03 | Abbott Lab | Capsules and method of producing |
| US2830010A (en) * | 1956-05-14 | 1958-04-08 | American Cyanamid Co | Powder-filled hexylresorcinol capsules |
| US2969331A (en) * | 1958-06-04 | 1961-01-24 | Ncr Co | Process of making dual-walled oil containing capsules |
| US2956926A (en) * | 1958-09-23 | 1960-10-18 | American Cyanamid Co | Coated citric acid particles |
| US2973301A (en) * | 1959-03-12 | 1961-02-28 | Lloyd Brothers Inc | Soft gelatin capsule |
-
0
- NL NL269886D patent/NL269886A/xx unknown
-
1960
- 1960-10-04 US US60312A patent/US3159545A/en not_active Expired - Lifetime
-
1961
- 1961-09-21 GB GB33882/61A patent/GB938828A/en not_active Expired
- 1961-10-02 BE BE608721A patent/BE608721A/en unknown
- 1961-12-28 FR FR883228A patent/FR1712M/en active Active
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE29474E (en) * | 1966-06-02 | 1977-11-15 | Pharmacia Ab | Method for the determination of proteins and polypeptides |
| EP0001822A3 (en) * | 1977-11-03 | 1979-08-22 | Hoechst Aktiengesellschaft | Process for the manufacture of pharmaceutical preparations |
| EP0049909A1 (en) * | 1977-11-03 | 1982-04-21 | Hoechst Aktiengesellschaft | Pharmaceutical compositions in the shape of solid dosage units, as well as method of preparing the same |
| DE3115053A1 (en) * | 1980-04-14 | 1982-02-18 | E.R. Squibb & Sons, Inc., 08540 Princeton, N.J. | CAPSULES CONTAINING RADIOACTIVE CONNECTIONS AND METHOD FOR FILLING THE SAME |
| EP0974346A3 (en) * | 1998-07-23 | 2000-05-24 | Nyl Service s.r.l. | Self-sealing capsule and method of producing same |
| US8298575B2 (en) | 1998-08-05 | 2012-10-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Two-part capsule to accept pharmaceutical preparations for powder inhalers |
| US8662076B2 (en) | 2005-01-11 | 2014-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers |
Also Published As
| Publication number | Publication date |
|---|---|
| BE608721A (en) | 1962-04-02 |
| NL269886A (en) | |
| FR1712M (en) | 1963-02-25 |
| US3159545A (en) | 1964-12-01 |
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