GB920866A - Process for the manufacture of minute capsules and the capsules obtained by such process - Google Patents
Process for the manufacture of minute capsules and the capsules obtained by such processInfo
- Publication number
- GB920866A GB920866A GB29392/61A GB2939261A GB920866A GB 920866 A GB920866 A GB 920866A GB 29392/61 A GB29392/61 A GB 29392/61A GB 2939261 A GB2939261 A GB 2939261A GB 920866 A GB920866 A GB 920866A
- Authority
- GB
- United Kingdom
- Prior art keywords
- liquid
- polymer material
- solution
- solvent
- ambient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002775 capsule Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000007788 liquid Substances 0.000 abstract 14
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 8
- 239000002861 polymer material Substances 0.000 abstract 8
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract 6
- 239000002904 solvent Substances 0.000 abstract 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- 239000000463 material Substances 0.000 abstract 4
- 239000001856 Ethyl cellulose Substances 0.000 abstract 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 2
- 238000013019 agitation Methods 0.000 abstract 2
- JOSWYUNQBRPBDN-UHFFFAOYSA-P ammonium dichromate Chemical compound [NH4+].[NH4+].[O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O JOSWYUNQBRPBDN-UHFFFAOYSA-P 0.000 abstract 2
- 229920006217 cellulose acetate butyrate Polymers 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 238000005538 encapsulation Methods 0.000 abstract 2
- 229920001249 ethyl cellulose Polymers 0.000 abstract 2
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 2
- 239000007791 liquid phase Substances 0.000 abstract 2
- 239000003094 microcapsule Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 239000003208 petroleum Substances 0.000 abstract 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 abstract 2
- 239000004926 polymethyl methacrylate Substances 0.000 abstract 2
- 230000000717 retained effect Effects 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
Microcapsules, each composed of a solid nucleous enclosed and retained by a wall of a water-insoluble, film-forming polymer material, are made by dissolving the polymer material in a first organic solvent liquid, adding, with agitation at a temperature above ambient, a second organic liquid which is miscible at least to a large extent with the first liquid but which is a non-solvent for the polymer material, thus causing a liquid phase composed of the first solvent liquid rich in dissolved polymer material to separate from the solution and deposit on the particles of nucleus material introduced at any time up to this point into the system, and thereafter lowering the temperature of the system to ambient and repeatedly adding more of the second liquid which removes the first liquid from the deposited material and brings the capsule walls to a rigid and self-supporting condition. Specified systems are a toluene/ethanol (4:1) solution of ethyl cellulose, methyl ethyl ketone or benzene solution of polymethyl methacrylate and an acetone solution of cellulose acetate butyrate, a petroleum fraction (B.P. 70+ DEG C.) being used as the second (nonsolvent) liquid in each case. Specific examples relate to the encapsulation of ammonium dichromate and reference is also made to pharmaceuticals.ALSO:Microcapsules, each composed of a solid nucleous enclosed and retained by a wall of a water-insoluble, film-forming polymer material, are made by dissolving the polymer material in a first organic solvent liquid, adding with agitation at a temperature above ambient a second organic liquid which is miscible at least to a large extent with the first liquid but which is a non-solvent for the polymer material, thus causing a liquid phase composed of the first solvent liquid rich in dissolved polymer material to separate from the solution and deposit on the particles of nucleus material introduced at any time up to this point into the system, and thereafter lowering the temperature of the system to ambient and repeatedly adding more of the second liquid which removes the first liquid from the deposited material and brings the capsule walls to a rigid and self-supporting condition. Specified systems are a toluene/ethanol (4 : 1) solution of ethyl cellulose, methyl ethyl ketone or benzene solution of polymethylmethacrylate and an acetone solution of cellulose acetate butyrate, a petroleum fraction (B.P. 70 + DEG C.) being used as the second (non-solvent) liquid in each case. Specific examples relate to the encapsulation of ammonium dichromate and reference is also made to pharmaceuticals.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6558260A | 1960-10-28 | 1960-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB920866A true GB920866A (en) | 1963-03-13 |
Family
ID=22063711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB29392/61A Expired GB920866A (en) | 1960-10-28 | 1961-08-15 | Process for the manufacture of minute capsules and the capsules obtained by such process |
Country Status (7)
| Country | Link |
|---|---|
| BE (2) | BE608763A (en) |
| CH (1) | CH417536A (en) |
| DE (1) | DE1189050B (en) |
| DK (1) | DK105583C (en) |
| FR (1) | FR1304561A (en) |
| GB (1) | GB920866A (en) |
| NL (2) | NL270717A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2126893A5 (en) * | 1971-02-19 | 1972-10-06 | Bayer Ag | |
| EP0099109A1 (en) * | 1982-07-16 | 1984-01-25 | Tanabe Seiyaku Co., Ltd. | Process for preparing free-flowing ethylcellulose microcapsules |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002057273A1 (en) * | 2001-01-20 | 2002-07-25 | Trigen Limited | Serine protease inhibitors comprising a hydrogen-bond acceptor |
-
0
- BE BE609550D patent/BE609550A/xx unknown
- NL NL129081D patent/NL129081C/xx active
- NL NL270717D patent/NL270717A/xx unknown
- BE BE608763D patent/BE608763A/xx unknown
-
1961
- 1961-08-15 GB GB29392/61A patent/GB920866A/en not_active Expired
- 1961-10-13 DK DK407561AA patent/DK105583C/en active
- 1961-10-24 DE DEN20716A patent/DE1189050B/en active Pending
- 1961-10-27 FR FR877185A patent/FR1304561A/en not_active Expired
- 1961-10-27 CH CH1254661A patent/CH417536A/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2126893A5 (en) * | 1971-02-19 | 1972-10-06 | Bayer Ag | |
| EP0099109A1 (en) * | 1982-07-16 | 1984-01-25 | Tanabe Seiyaku Co., Ltd. | Process for preparing free-flowing ethylcellulose microcapsules |
| US4542042A (en) * | 1982-07-16 | 1985-09-17 | Tanabe Seiyaku Co., Ltd. | Process for preparing free-flowing ethylcellulose microcapsules |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1189050B (en) | 1965-03-18 |
| NL270717A (en) | |
| NL129081C (en) | |
| BE608763A (en) | |
| CH417536A (en) | 1966-07-31 |
| DK105583C (en) | 1966-10-17 |
| BE609550A (en) | |
| FR1304561A (en) | 1962-09-21 |
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