GB929985A - - Google Patents
Info
- Publication number
- GB929985A GB929985A GB929985DA GB929985A GB 929985 A GB929985 A GB 929985A GB 929985D A GB929985D A GB 929985DA GB 929985 A GB929985 A GB 929985A
- Authority
- GB
- United Kingdom
- Prior art keywords
- treatment
- steroids
- nov
- methylene
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000011282 treatment Methods 0.000 abstract 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000012445 acidic reagent Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
929,985. 6-Methylene-steroids. BRITISH DRUG HOUSES Ltd. Nov. 3, 1961 [Nov. 7. 1960], No. 39535/61. Divided out of 929,983. Class 2(3). The invention comprises 6-methylene-3- oxo-#<SP>4</SP>-steroids and the preparation thereof by treating a 3-enol ether of a 6-hydroxymethyl steroid wih an acidic reagent. Such treatments include solution of the steroid in acetic acid followed by dilution with water, treatment with catalytic quantities of acids such as toluene p-sulphonic acid in solvents such as dioxan, treatment with sulphuric acid in ethanol and treatment with Lewis acids in acetone. A large number of examples are provided and an extensive list of starting materials and groups which may be present therein is given. These groups are the same as those detailed in Specification 929,983. Specification 929,984 also is referred to.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB929985A true GB929985A (en) |
Family
ID=1753695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB929985D Active GB929985A (en) |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB929985A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2584725A1 (en) * | 1985-07-09 | 1987-01-16 | Erba Farmitalia | SUBSTITUTED ANDROSTA-1,4-DIENE-3,17-DIONES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING SAME |
| EP0253591A1 (en) * | 1986-07-14 | 1988-01-20 | FARMITALIA CARLO ERBA S.r.l. | New 6- or 7-methylenandrosta-1, 4-diene-3,17-dione derivatives and process for their preparation |
| EP0307135A1 (en) * | 1987-09-11 | 1989-03-15 | FARMITALIA CARLO ERBA S.r.l. | 17-substituted androsta-1,4-dien-3-one derivatives |
| US4822528A (en) * | 1986-09-17 | 1989-04-18 | Farmitalia Carlo Erba S.R.L. | 4-substituted 6-alkylidenandrosteine-3,17-dione derivatives and process for their preparation |
| US4840943A (en) * | 1986-06-20 | 1989-06-20 | Farmitalia Carlo Ebra S.R.L. | Androst-4-ene-3,17-diones and process for their preparation |
-
0
- GB GB929985D patent/GB929985A/en active Active
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2584725A1 (en) * | 1985-07-09 | 1987-01-16 | Erba Farmitalia | SUBSTITUTED ANDROSTA-1,4-DIENE-3,17-DIONES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING SAME |
| US4808616A (en) * | 1985-07-09 | 1989-02-28 | Farmitalia Carlo Erba S.R.L. | 6-substituted androsta-1,4-diene-3,17-diones |
| US4904650A (en) * | 1985-07-09 | 1990-02-27 | Farmitalia Carlo Erba S.P.A. | Substituted androsta-1,4-diene-3,17-diones |
| US4840943A (en) * | 1986-06-20 | 1989-06-20 | Farmitalia Carlo Ebra S.R.L. | Androst-4-ene-3,17-diones and process for their preparation |
| EP0253591A1 (en) * | 1986-07-14 | 1988-01-20 | FARMITALIA CARLO ERBA S.r.l. | New 6- or 7-methylenandrosta-1, 4-diene-3,17-dione derivatives and process for their preparation |
| US4824830A (en) * | 1986-07-14 | 1989-04-25 | Farmitalia Carlo Erba S.R.L. | 6- or 7-methylenandrosta-1,4-diene-3,17-dione derivatives and process for their preparation |
| US4822528A (en) * | 1986-09-17 | 1989-04-18 | Farmitalia Carlo Erba S.R.L. | 4-substituted 6-alkylidenandrosteine-3,17-dione derivatives and process for their preparation |
| EP0307135A1 (en) * | 1987-09-11 | 1989-03-15 | FARMITALIA CARLO ERBA S.r.l. | 17-substituted androsta-1,4-dien-3-one derivatives |
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