GB929405A - Processes for the encapsulation of particles - Google Patents
Processes for the encapsulation of particlesInfo
- Publication number
- GB929405A GB929405A GB3916159A GB3916159A GB929405A GB 929405 A GB929405 A GB 929405A GB 3916159 A GB3916159 A GB 3916159A GB 3916159 A GB3916159 A GB 3916159A GB 929405 A GB929405 A GB 929405A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- gelatine
- aqueous solution
- gallic acid
- tannic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002245 particle Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000005538 encapsulation Methods 0.000 title 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 abstract 4
- 239000001263 FEMA 3042 Substances 0.000 abstract 4
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 abstract 4
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 abstract 4
- 229940074391 gallic acid Drugs 0.000 abstract 4
- 238000002360 preparation method Methods 0.000 abstract 4
- 235000015523 tannic acid Nutrition 0.000 abstract 4
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 abstract 4
- 229940033123 tannic acid Drugs 0.000 abstract 4
- 229920002258 tannic acid Polymers 0.000 abstract 4
- 239000001828 Gelatine Substances 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 3
- 239000000084 colloidal system Substances 0.000 abstract 3
- 239000000839 emulsion Substances 0.000 abstract 3
- 229920000159 gelatin Polymers 0.000 abstract 3
- 235000019322 gelatine Nutrition 0.000 abstract 3
- 238000005354 coacervation Methods 0.000 abstract 2
- 235000004515 gallic acid Nutrition 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 239000003921 oil Substances 0.000 abstract 2
- PYSRRFNXTXNWCD-UHFFFAOYSA-N 3-(2-phenylethenyl)furan-2,5-dione Chemical compound O=C1OC(=O)C(C=CC=2C=CC=CC=2)=C1 PYSRRFNXTXNWCD-UHFFFAOYSA-N 0.000 abstract 1
- 102000008946 Fibrinogen Human genes 0.000 abstract 1
- 108010049003 Fibrinogen Proteins 0.000 abstract 1
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 108010039918 Polylysine Proteins 0.000 abstract 1
- 229920000147 Styrene maleic anhydride Polymers 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000003899 bactericide agent Substances 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 239000002285 corn oil Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003337 fertilizer Substances 0.000 abstract 1
- 229940012952 fibrinogen Drugs 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 239000002778 food additive Substances 0.000 abstract 1
- 235000013373 food additive Nutrition 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002480 mineral oil Substances 0.000 abstract 1
- 239000000575 pesticide Substances 0.000 abstract 1
- 230000008635 plant growth Effects 0.000 abstract 1
- 229920000768 polyamine Polymers 0.000 abstract 1
- 229920000656 polylysine Polymers 0.000 abstract 1
- 108010055896 polyornithine Proteins 0.000 abstract 1
- 229920002714 polyornithine Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- HFFLGKNGCAIQMO-UHFFFAOYSA-N trichloroacetaldehyde Chemical compound ClC(Cl)(Cl)C=O HFFLGKNGCAIQMO-UHFFFAOYSA-N 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
- A01N25/28—Microcapsules or nanocapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/10—Complex coacervation, i.e. interaction of oppositely charged particles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Dispersion Chemistry (AREA)
- Environmental Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Agronomy & Crop Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Colloid Chemistry (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
Membranes formed by the coacervation of a material comprising at least one gelable hydrophilic colloid having amino groups and peptide linkages (e.g. proteins and polyamines) are treated with an aqueous solution of one or more of tannic acid, gallic acid or di-gallic acid to improve their physical characteristics, in particular their impermeability to fluids. The membranes may be formed by simple or complex coacervation of one or more of the above colloids by any process and they may encapsulate solids, oils, hydrophilic liquid-in-oil and oil-in-hydrophilic liquid emulsions which may contain "active" ingredients which render the preparations suitable as fertilizers, plant growth hormone preparations, bactericides, pesticides, vitamin preparations, medicines and food additives. Treatment is preferably carried out subsequent to the gelling (e.g. by cooling) of the concervate under conditions of time and pH (generally acid) which allow the properties of the product to be varied. Specified colloids of the above type are gelatine, fibrinogen, polylysine and polyornithine. Specific examples relate to the treatment of: (a) particles of an aqueous solution of urea-in-corn oil emulsion encapsulated in gelatine with tannic acid, gallic acid and di-gallic acid; (b) a similar preparation comprising 1,2,4,5,6,7,8,8-octachloro-4,17-methano-3a ,4,7, p 7a -tetrahydroindan in place of the urea of (a) with tannic acid; (c) particles of an aqueous solution of chloral hydrate-in-mineral oil emulsion encapsulated in a complex coacervate of gelatine and styrene-maleic anhydride copolymer with tannic acid. Specifications 476,869, 483,550, 573,678, 751,600, 911,483, 929,401, 929,402, 929,403, 929,408, and 929,409 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78193058A | 1958-12-22 | 1958-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB929405A true GB929405A (en) | 1963-06-19 |
Family
ID=25124414
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3916259A Expired GB929406A (en) | 1958-12-22 | 1959-11-18 | A process for the production of encapsulated material |
| GB3916159A Expired GB929405A (en) | 1958-12-22 | 1959-11-18 | Processes for the encapsulation of particles |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3916259A Expired GB929406A (en) | 1958-12-22 | 1959-11-18 | A process for the production of encapsulated material |
Country Status (3)
| Country | Link |
|---|---|
| CH (1) | CH396845A (en) |
| DE (1) | DE1141263B (en) |
| GB (2) | GB929406A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3965033A (en) * | 1970-07-27 | 1976-06-22 | Fuji Photo Film Co., Ltd. | Process for the production of oil-containing microcapsules |
| FR2464093A1 (en) * | 1979-08-30 | 1981-03-06 | Roussel Uclaf | PROCESS FOR THE PREPARATION OF SUSPENSIONS OR STABLE POWDERS OF STABLE MICROCAPSULES WITH VARIABLE POROSITY AND THE PRODUCTS OBTAINED THEREBY |
| EP0038985A1 (en) * | 1980-04-26 | 1981-11-04 | Bayer Ag | Microcapsules having a specific opening temperature, method for their preparation and their application |
| FR2857592A1 (en) * | 2003-07-18 | 2005-01-21 | Sod Conseils Rech Applic | NEW PROCESS FOR THE PREPARATION OF MICROPARTICLES |
| WO2005105057A1 (en) * | 2004-04-23 | 2005-11-10 | Amgen Inc. | Sustained release formulations |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1044134A (en) * | 1975-04-09 | 1978-12-12 | Minnesota Mining And Manufacturing Company | Microcapsule insecticide composition |
| US4808408A (en) * | 1983-05-11 | 1989-02-28 | Bend Research, Inc. | Microcapsules prepared by coacervation |
| EP1220657A1 (en) * | 1999-10-14 | 2002-07-10 | 1170535 Ontario Inc. | Liposome encapsulated silver salt compositions |
| US9822364B2 (en) | 2008-03-11 | 2017-11-21 | Yale University | Compositions and methods for controlled delivery of inhibitory ribonucleic acids |
| WO2013123492A2 (en) | 2012-02-17 | 2013-08-22 | Massachusetts Institute Of Technology | Glucose-responsive microgels for closed loop insulin delivery |
| US10159743B2 (en) | 2012-03-16 | 2018-12-25 | The Johns Hopkins University | Non-linear multiblock copolymer-drug conjugates for the delivery of active agents |
| CA2867381C (en) | 2012-03-16 | 2016-09-20 | The Johns Hopkins University | Controlled release formulations for the delivery of hif-1 inhibitors |
| WO2014160404A1 (en) | 2013-03-13 | 2014-10-02 | The Regents Of The University Of California | Improved oral drug devices and drug formulations |
| JP2017503860A (en) | 2014-01-10 | 2017-02-02 | チャンバー ワークス，エルエルシー | Individualized substances for application to the skin or addition to tattoo inks and methods for their production |
| WO2015138951A1 (en) | 2014-03-14 | 2015-09-17 | Chamber Works, Llc | Articles of jewelry containing a personalizing additive such as dna and methods of making |
| US10722468B2 (en) | 2014-08-14 | 2020-07-28 | Brown University | Compositions for stabilizing and delivering proteins |
| BR112017012706A2 (en) | 2014-12-15 | 2018-03-13 | The Johns Hopkins University | sunitinib formulations and methods for their use in the treatment of eye disorders |
| CN107206099A (en) | 2015-01-20 | 2017-09-26 | 约翰霍普金斯大学 | Compositions for sustained release of antiglaucoma agents for controlling intraocular pressure |
| ES2908479T3 (en) | 2015-08-26 | 2022-04-29 | Achillion Pharmaceuticals Inc | Compounds for the treatment of immune and inflammatory disorders |
| AR106018A1 (en) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | ARYL, HETEROARYL AND HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS |
| PL3347794T3 (en) | 2015-09-04 | 2024-01-03 | Yale University | Polymeric bile acid nanocompositions targeting the pancreas and colon |
| CN114469872A (en) | 2015-11-12 | 2022-05-13 | 灰色视觉公司 | Aggregate microparticles for therapy |
| EP3416976A2 (en) | 2016-02-16 | 2018-12-26 | Yale University | Compositions for enhancing targeted gene editing and methods of use thereof |
| AU2017221424A1 (en) | 2016-02-16 | 2018-09-20 | Yale University | Compositions and methods for treatment of cystic fibrosis |
| US20190022016A1 (en) | 2016-03-02 | 2019-01-24 | The Johns Hopkins University | Compositions for sustained release of anti-glaucoma agents to control intraocular pressure |
| EP3448389B1 (en) | 2016-06-27 | 2021-09-29 | Achillion Pharmaceuticals, Inc. | Quinazoline and indole compounds to treat medical disorders |
| CA3036693A1 (en) | 2016-09-13 | 2018-03-22 | North Carolina State University | Platelet compositions and methods for the delivery of therapeutic agents |
| US20200113821A1 (en) | 2017-04-04 | 2020-04-16 | Yale University | Compositions and methods for in utero delivery |
| JP2020519585A (en) | 2017-05-10 | 2020-07-02 | グレイバグ ビジョン インコーポレイテッド | Extended release microparticles and suspensions thereof for medical therapy |
| WO2020028907A1 (en) | 2018-08-03 | 2020-02-06 | Brown University | Compositions and methods for improving the bioavailability of glp1 and analogues thereof |
| WO2020033951A1 (en) | 2018-08-10 | 2020-02-13 | Yale University | Compositions and methods for embryonic gene editing in vitro |
| EP4167958A1 (en) | 2020-06-19 | 2023-04-26 | Yale University | Polymeric bile acid ester nanoparticles comprising an immunomodulator agent to induce antigen-specific tolerance |
| US20240042024A1 (en) | 2020-11-27 | 2024-02-08 | David A. Horwitz | Methods and compositions for treatment of immune-mediated diseases |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2800457A (en) * | 1953-06-30 | 1957-07-23 | Ncr Co | Oil-containing microscopic capsules and method of making them |
-
1959
- 1959-11-18 GB GB3916259A patent/GB929406A/en not_active Expired
- 1959-11-18 GB GB3916159A patent/GB929405A/en not_active Expired
- 1959-12-16 DE DEU6742A patent/DE1141263B/en active Pending
- 1959-12-19 CH CH8206059A patent/CH396845A/en unknown
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3965033A (en) * | 1970-07-27 | 1976-06-22 | Fuji Photo Film Co., Ltd. | Process for the production of oil-containing microcapsules |
| FR2464093A1 (en) * | 1979-08-30 | 1981-03-06 | Roussel Uclaf | PROCESS FOR THE PREPARATION OF SUSPENSIONS OR STABLE POWDERS OF STABLE MICROCAPSULES WITH VARIABLE POROSITY AND THE PRODUCTS OBTAINED THEREBY |
| EP0025379A3 (en) * | 1979-08-30 | 1981-09-02 | Roussel-Uclaf | Process for the preparation of suspensions or stable powders of stable microcapsules having a variable porosity, and products so obtained |
| EP0038985A1 (en) * | 1980-04-26 | 1981-11-04 | Bayer Ag | Microcapsules having a specific opening temperature, method for their preparation and their application |
| US4402856A (en) | 1980-04-26 | 1983-09-06 | Bayer Aktiengesellschaft | Microcapsules with a defined opening temperature, a process for their production and their use |
| FR2857592A1 (en) * | 2003-07-18 | 2005-01-21 | Sod Conseils Rech Applic | NEW PROCESS FOR THE PREPARATION OF MICROPARTICLES |
| WO2005009415A3 (en) * | 2003-07-18 | 2005-04-07 | Sod Conseils Rech Applic | Novel method for microparticles production |
| WO2005105057A1 (en) * | 2004-04-23 | 2005-11-10 | Amgen Inc. | Sustained release formulations |
| US7323169B2 (en) | 2004-04-23 | 2008-01-29 | Amgen Inc. | Sustained release formulations |
| US7732399B2 (en) | 2004-04-23 | 2010-06-08 | Amgen Inc. | Sustained release formulations |
Also Published As
| Publication number | Publication date |
|---|---|
| GB929406A (en) | 1963-06-19 |
| DE1141263B (en) | 1962-12-20 |
| CH396845A (en) | 1965-08-15 |
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