GB927666A - Process for the manufacture of a sulphur-containing derivative of vitamin b - Google Patents
Process for the manufacture of a sulphur-containing derivative of vitamin bInfo
- Publication number
- GB927666A GB927666A GB2961461A GB2961461A GB927666A GB 927666 A GB927666 A GB 927666A GB 2961461 A GB2961461 A GB 2961461A GB 2961461 A GB2961461 A GB 2961461A GB 927666 A GB927666 A GB 927666A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- disulphide
- hydroxy
- water
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title 1
- 239000005864 Sulphur Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- SRRKNRDXURUMPP-UHFFFAOYSA-N sodium disulfide Chemical compound [Na+].[Na+].[S-][S-] SRRKNRDXURUMPP-UHFFFAOYSA-N 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- MGOOVKWSWIYTIO-UHFFFAOYSA-N 4,5-dibromo-2,6-dimethylpyridin-3-ol Chemical compound CC1=NC(C)=C(Br)C(Br)=C1O MGOOVKWSWIYTIO-UHFFFAOYSA-N 0.000 abstract 1
- NNPYXLKBSNYATK-UHFFFAOYSA-N 5-(bromomethyl)-4-(hydroxymethyl)-2-methylpyridin-3-ol Chemical compound CC1=NC=C(CBr)C(CO)=C1O NNPYXLKBSNYATK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Bis-[4-hydroxy-methyl-5-hydroxy-6-methyl-pyridyl-(3) -methyl]-disulphide is obtained by reacting an acid addition salt of 3,4-bis-bromo-methyl-5-hydroxy-6-methyl-pyridine or 3-bromomethyl-4-hydroxymethyl-5-hydroxy-6-methyl-pyridine in the presence of water and/or a water miscible organic solvent with a water-soluble inorganic disulphide preferably sodium disulphide. The dibromide is preferably heated in aqueous solution to 5070 DEG C. for about 15 minutes and then added drop by drop to sodium disulphide at room temperature; the required disulphide precipitating from the reaction mixture. Specified water miscible solvents are methanol, ethanol, isopropanol, acetone, dioxane, tetrahydrofuran, dimethyl formamide, glycerol and glycol. The disulphide is washed with acetone or methanol and then dried and recrystallised from butanol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEM0004639 | 1960-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB927666A true GB927666A (en) | 1963-05-29 |
Family
ID=7292784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2961461A Expired GB927666A (en) | 1960-08-27 | 1961-08-16 | Process for the manufacture of a sulphur-containing derivative of vitamin b |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB927666A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2466728C1 (en) * | 2011-09-12 | 2012-11-20 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) | Phosphonium salts on basis of pyridoxine derivatives |
-
1961
- 1961-08-16 GB GB2961461A patent/GB927666A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2466728C1 (en) * | 2011-09-12 | 2012-11-20 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) | Phosphonium salts on basis of pyridoxine derivatives |
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