Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3903758A
Inventor
Emilio Testa
Luigi Fontanella
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Gruppo Lepetit SpA
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Lepetit SpA
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Publication date
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Priority to GB3903758ApriorityCriticalpatent/GB911591A/en
Publication of GB911591ApublicationCriticalpatent/GB911591A/en
C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J75/00—Processes for the preparation of steroids in general
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Chemical & Material Sciences
(AREA)
Organic Chemistry
(AREA)
Health & Medical Sciences
(AREA)
General Health & Medical Sciences
(AREA)
Steroid Compounds
(AREA)
Abstract
The invention comprises 16a -methyl-desoxy-corticosterone 21-acetate and 16a -methyl-4-pregnene-3,20-dione, and the preparation of 16a -methyl-desoxycorticosterone 21-acetate by treating 16a -methyl-4-pregnene-3,20-dione with iodine and calcium oxide to form the corresponding 21-iodo compound and replacing the 21-iodine atom by an acetoxy group. The above process may be modified in that the 16a -methyl-4-pregnene-3,20-dione is prepared by oxidising 16a -methyl-3b -hydroxy-5-pregnen-20-one by the Oppenauer method.
Procedure for the preparation of 9-alpha-16 - fluor-16 - metilenprednisolona or prednisona and its 21-esteres. (Machine-translation by Google Translate, not legally binding)