GB917456A - Suppository composition and preparation thereof - Google Patents
Suppository composition and preparation thereofInfo
- Publication number
- GB917456A GB917456A GB36137/59A GB3613759A GB917456A GB 917456 A GB917456 A GB 917456A GB 36137/59 A GB36137/59 A GB 36137/59A GB 3613759 A GB3613759 A GB 3613759A GB 917456 A GB917456 A GB 917456A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid phosphate
- polyethylene glycol
- carrier material
- salt
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 239000000829 suppository Substances 0.000 title abstract 3
- 239000012876 carrier material Substances 0.000 abstract 4
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 abstract 4
- 229910019142 PO4 Inorganic materials 0.000 abstract 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 3
- 239000010452 phosphate Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 235000019980 sodium acid phosphate Nutrition 0.000 abstract 3
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 150000001340 alkali metals Chemical class 0.000 abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Substances OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 abstract 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 125000005588 carbonic acid salt group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000004310 lactic acid Substances 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 abstract 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 abstract 1
- 229940048086 sodium pyrophosphate Drugs 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 abstract 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Sodium acid phosphate is heated, e.g. for 12 hours at 150 DEG C. or for 24 hours at 130 DEG C. to produce a "dehydrated sodium acid phosphate" by the reaction: <FORM:0917456/III/1> Analysis of the product indicates that it is an equilibrium mixture of sodium acid phosphate and anhydrous sodium pyrophosphate.ALSO:A suppository composition of low surface activity consists essentially of polyethylene glycol which is solid at normal temperatures (as carrier material), a salt of carbonic acid and an alkali metal acid phosphate or a dehydrated alkali metal acid phosphate or a salt of lactic, citric or tartaric acid. The suppository is preferably prepared by blending together two mixtures, one of which contains the carbonic acid salt and the carrier material and the other of which contains the carrier material and the phosphate or other reactive salt, whereby the particles of the two components of the CO2-producing couple are each enclosed in a protective film and are prevented from coming into contact until the carrier material dissolves. A preferred composition consists essentially of 15 to 44% polyethylene glycol 6000, 9 to 26% polyethylene glycol 1540, 6 to 17.4% polyethylene glycol 400, 7 to 38% sodium acid phosphate and 5 to 30% sodium bicarbonate.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77061558A | 1958-10-30 | 1958-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB917456A true GB917456A (en) | 1963-02-06 |
Family
ID=25089162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB36137/59A Expired GB917456A (en) | 1958-10-30 | 1959-10-26 | Suppository composition and preparation thereof |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE584120A (en) |
| FR (1) | FR316M (en) |
| GB (1) | GB917456A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3358687A (en) * | 1965-12-06 | 1967-12-19 | Sterling Drug Inc | Suppositories |
| US4265874A (en) * | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US5223246A (en) * | 1990-02-14 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Effervescent composition, its production and use |
| EP0858326A4 (en) * | 1996-05-08 | 1999-09-29 | Graig A Aronchick | Non-aqueous colonic purgative formulations |
| US6488961B1 (en) | 1996-09-20 | 2002-12-03 | Ethypharm, Inc. | Effervescent granules and methods for their preparation |
| US6649186B1 (en) | 1996-09-20 | 2003-11-18 | Ethypharm | Effervescent granules and methods for their preparation |
| WO2010143004A3 (en) * | 2009-06-10 | 2011-12-22 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Glycerol-free osmotic laxative suppository |
| IT201700054380A1 (en) * | 2017-05-19 | 2018-11-19 | Aboca Spa Societa Agricola | COMPOSITIONS CONTAINING CARBON DIOXIDE RELEASE SYSTEMS OBTAINED FROM VEGETABLE JUICES |
| IT201900000265A1 (en) * | 2019-01-09 | 2020-07-09 | Caprika Srl | "USE OF POLYETHYLENGLYCOL BY RECTAL WAY IN THE TREATMENT OF CONSTIPATION" |
| WO2021105792A1 (en) * | 2019-11-28 | 2021-06-03 | Caprika Srl | Rectal-use composition for the treatment of constipation |
-
1959
- 1959-10-26 GB GB36137/59A patent/GB917456A/en not_active Expired
- 1959-10-29 BE BE584120A patent/BE584120A/en unknown
-
1960
- 1960-08-26 FR FR836873A patent/FR316M/en active Active
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3358687A (en) * | 1965-12-06 | 1967-12-19 | Sterling Drug Inc | Suppositories |
| US4265874A (en) * | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US5223246A (en) * | 1990-02-14 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Effervescent composition, its production and use |
| EP0858326A4 (en) * | 1996-05-08 | 1999-09-29 | Graig A Aronchick | Non-aqueous colonic purgative formulations |
| US6488961B1 (en) | 1996-09-20 | 2002-12-03 | Ethypharm, Inc. | Effervescent granules and methods for their preparation |
| US6649186B1 (en) | 1996-09-20 | 2003-11-18 | Ethypharm | Effervescent granules and methods for their preparation |
| WO2010143004A3 (en) * | 2009-06-10 | 2011-12-22 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Glycerol-free osmotic laxative suppository |
| EA021632B1 (en) * | 2009-06-10 | 2015-07-30 | Эгиш Дьёдьсердьяр Ньильваношан Мюкеде Ресвеньтаршашаг | Glycerol-free osmotic laxative suppository and process for preparation thereof |
| IT201700054380A1 (en) * | 2017-05-19 | 2018-11-19 | Aboca Spa Societa Agricola | COMPOSITIONS CONTAINING CARBON DIOXIDE RELEASE SYSTEMS OBTAINED FROM VEGETABLE JUICES |
| WO2018211372A1 (en) * | 2017-05-19 | 2018-11-22 | Aboca S.P.A Società Agricola | Compositions containing systems of release of carbon dioxide obtained from plant juices |
| CN110650725A (en) * | 2017-05-19 | 2020-01-03 | 阿波卡-阿格里科拉共同股份公司 | Compositions comprising carbon dioxide release systems obtained from plant juices |
| US11083691B2 (en) * | 2017-05-19 | 2021-08-10 | Aboca S.P.A. Società Agricola | Compositions containing systems of release of carbon dioxide obtained from plant juices |
| EA038832B1 (en) * | 2017-05-19 | 2021-10-26 | Абока С.П.А. Сосиета' Агрикола | Compositions containing systems of release of carbon dioxide obtained from plant juices |
| CN110650725B (en) * | 2017-05-19 | 2023-04-07 | 阿波卡-阿格里科拉共同股份公司 | Composition obtained from plant juice comprising a carbon dioxide releasing system |
| IT201900000265A1 (en) * | 2019-01-09 | 2020-07-09 | Caprika Srl | "USE OF POLYETHYLENGLYCOL BY RECTAL WAY IN THE TREATMENT OF CONSTIPATION" |
| WO2021105792A1 (en) * | 2019-11-28 | 2021-06-03 | Caprika Srl | Rectal-use composition for the treatment of constipation |
Also Published As
| Publication number | Publication date |
|---|---|
| FR316M (en) | 1961-03-20 |
| BE584120A (en) | 1960-04-29 |
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