GB908282A - Coated pharmaceutical granules and tablets thereof - Google Patents
Coated pharmaceutical granules and tablets thereofInfo
- Publication number
- GB908282A GB908282A GB523358A GB523358A GB908282A GB 908282 A GB908282 A GB 908282A GB 523358 A GB523358 A GB 523358A GB 523358 A GB523358 A GB 523358A GB 908282 A GB908282 A GB 908282A
- Authority
- GB
- United Kingdom
- Prior art keywords
- granules
- coated
- tabletted
- medicament
- mixed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008187 granular material Substances 0.000 title abstract 15
- 239000003814 drug Substances 0.000 abstract 4
- CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical compound CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 abstract 4
- 239000000126 substance Substances 0.000 abstract 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 3
- 229930006000 Sucrose Natural products 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000005720 sucrose Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 2
- 239000001856 Ethyl cellulose Substances 0.000 abstract 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 230000001079 digestive effect Effects 0.000 abstract 2
- 229920001249 ethyl cellulose Polymers 0.000 abstract 2
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 2
- 239000012530 fluid Substances 0.000 abstract 2
- 239000008101 lactose Substances 0.000 abstract 2
- 229940113116 polyethylene glycol 1000 Drugs 0.000 abstract 2
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 abstract 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 abstract 1
- 239000001836 Dioctyl sodium sulphosuccinate Substances 0.000 abstract 1
- BALXUFOVQVENIU-GNAZCLTHSA-N Ephedrine hydrochloride Chemical compound Cl.CN[C@@H](C)[C@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-GNAZCLTHSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 239000001506 calcium phosphate Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 229920002301 cellulose acetate Polymers 0.000 abstract 1
- 229920003086 cellulose ether Polymers 0.000 abstract 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 abstract 1
- 229940038472 dicalcium phosphate Drugs 0.000 abstract 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 abstract 1
- 229960002534 ephedrine hydrochloride Drugs 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 abstract 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
Prolonged acting granules of a medicament consist of granules of the medicament coated with a composition comprising a non-toxic, impermeable cellulose ether or cellulose ester which is very sparingly soluble in the digestive fluids of the alimentary tract and a substance which is readily soluble in the digestive fluids of the alimentary tract and is present as 5 to 30% by weight of the coating. The granules of the medicament are prepared in a conventional manner. The medicament may be mixed with a diluent such as sucrose or lactose before granulating. The granules are coated by rotating them in a coating pan and spraying on to them a solution in a volatile solvent, e.g. acetone or alcohol of the film-forming substance and the readily soluble substance. The granules are used as such or put up into capsules or caskets or compressed into tablets. They may be mixed with uncoated granules or an inert substance such as lactose, sucrose, glucose or dicalcium phosphate and then compressed into tablets. In examples: (a) granules of acetyl-salicylic acid are coated with ethyl cellulose and polyethylene glycol 1000 and a mix of coated and uncoated granules tabletted; (b) granules of ephedrine hydrochloride, sodium chloride and sucrose are coated with cellulose acetate, polyethylene glycol 1000 and polyoxy-ethylene sorbitan monolaurate, and a mixture of coated and uncoated granules are tabletted; (c) granules of acetylsalicylic acid are coated with ethyl cellulose and dioctyl sodium sulpho-succinate and granules of p-ethoxyacetanilide and methyltheobromine are likewise coated, the granules mixed and tabletted; (d) acetyl-salicylic acid, p-ethoxyacetanilide and methyl-theobromine are coated as in (c), mixed with uncoated granules and tabletted.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE575775D BE575775A (en) | 1958-02-18 | ||
| GB523358A GB908282A (en) | 1958-02-18 | 1958-02-18 | Coated pharmaceutical granules and tablets thereof |
| ES0247237A ES247237A1 (en) | 1958-02-18 | 1959-02-14 | Coated pharmaceutical granules and tablets thereof |
| BR10848459A BR5908484D0 (en) | 1958-02-18 | 1959-02-16 | IMPROVEMENTS IN OR RELATING TO PHARMACEUTICAL PREPARATIONS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB523358A GB908282A (en) | 1958-02-18 | 1958-02-18 | Coated pharmaceutical granules and tablets thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB908282A true GB908282A (en) | 1962-10-17 |
Family
ID=9792213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB523358A Expired GB908282A (en) | 1958-02-18 | 1958-02-18 | Coated pharmaceutical granules and tablets thereof |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE575775A (en) |
| BR (1) | BR5908484D0 (en) |
| ES (1) | ES247237A1 (en) |
| GB (1) | GB908282A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4101651A (en) * | 1975-09-29 | 1978-07-18 | Meiji Seika Kaisha, Ltd. | Process for preparing preparations for oral administration |
| FR2385388A1 (en) * | 1977-04-01 | 1978-10-27 | Hoechst Ag | |
| FR2430766A1 (en) * | 1978-07-15 | 1980-02-08 | Boehringer Sohn Ingelheim | DELAYED DRUG FORM COMPRISING AN INSOLUBLE POROUS BROADCASTING ENVELOPE |
| EP0355247A3 (en) * | 1988-08-22 | 1990-12-12 | Ss Pharmaceutical Co., Ltd. | Compressed-molded preparations |
| GB2241168A (en) * | 1990-02-26 | 1991-08-28 | Int Medical Research Limited | Controlled release product containing salicylate |
| WO2005084457A1 (en) * | 2004-03-04 | 2005-09-15 | Goekhan Cem | Artificial fruit |
| EP1286662A4 (en) * | 2000-05-19 | 2009-08-05 | Yamanouchi Pharma Tech Inc | TABLETS AND METHODS FOR MODIFIED RELEASE OF HYDROPHILIC AGENTS OR OTHER AGENTS |
| CN110882281A (en) * | 2019-11-30 | 2020-03-17 | 江苏艾兰得营养品有限公司 | Probiotic enteric-coated tablet and preparation method thereof |
-
0
- BE BE575775D patent/BE575775A/xx unknown
-
1958
- 1958-02-18 GB GB523358A patent/GB908282A/en not_active Expired
-
1959
- 1959-02-14 ES ES0247237A patent/ES247237A1/en not_active Expired
- 1959-02-16 BR BR10848459A patent/BR5908484D0/en unknown
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4101651A (en) * | 1975-09-29 | 1978-07-18 | Meiji Seika Kaisha, Ltd. | Process for preparing preparations for oral administration |
| FR2385388A1 (en) * | 1977-04-01 | 1978-10-27 | Hoechst Ag | |
| FR2430766A1 (en) * | 1978-07-15 | 1980-02-08 | Boehringer Sohn Ingelheim | DELAYED DRUG FORM COMPRISING AN INSOLUBLE POROUS BROADCASTING ENVELOPE |
| US4578264A (en) * | 1978-07-15 | 1986-03-25 | Boehringer Ingelheim Gmbh | Retard form of pharmaceuticals with insoluble porous diffusion coatings |
| US5186943A (en) * | 1988-08-22 | 1993-02-16 | Ss Pharmaceutical Co., Ltd. | Compressed-molded preparations |
| EP0355247A3 (en) * | 1988-08-22 | 1990-12-12 | Ss Pharmaceutical Co., Ltd. | Compressed-molded preparations |
| US5275825A (en) * | 1988-08-22 | 1994-01-04 | Ss Pharmaceutical Co., Ltd. | Compressed-molded preparations |
| US5156849A (en) * | 1990-02-26 | 1992-10-20 | Byrne Rynne Holdings Limited | Pharmaceutical composition |
| GB2241168A (en) * | 1990-02-26 | 1991-08-28 | Int Medical Research Limited | Controlled release product containing salicylate |
| EP1286662A4 (en) * | 2000-05-19 | 2009-08-05 | Yamanouchi Pharma Tech Inc | TABLETS AND METHODS FOR MODIFIED RELEASE OF HYDROPHILIC AGENTS OR OTHER AGENTS |
| WO2005084457A1 (en) * | 2004-03-04 | 2005-09-15 | Goekhan Cem | Artificial fruit |
| GB2427993A (en) * | 2004-03-04 | 2007-01-17 | Cem Goekhan | Artificial fruit |
| GB2427993B (en) * | 2004-03-04 | 2008-06-11 | Cem Goekhan | Low glycaemic index sugar |
| CN110882281A (en) * | 2019-11-30 | 2020-03-17 | 江苏艾兰得营养品有限公司 | Probiotic enteric-coated tablet and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| BE575775A (en) | |
| ES247237A1 (en) | 1959-06-16 |
| BR5908484D0 (en) | 1973-06-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SU1706373A3 (en) | Method for obtaining a means with controlled release of active substance | |
| US3080294A (en) | Sustained release type of pharmaceutical vehicles | |
| FI97445C (en) | Process for the preparation of a slow-release pharmaceutical composition | |
| US4478819A (en) | Novel oral preparations | |
| US3082154A (en) | Improved free-flowing coated antimalarial salts in particulate form | |
| US3131123A (en) | Enteric tablets and manufacture thereof | |
| KR840000230A (en) | Method for Preparation of Bromexene Sustained-Release Formulation | |
| EP0247983A2 (en) | New pharmaceutical preparation for oral use | |
| UA29513C2 (en) | PHARMACEUTICAL COMPOSITION, CONTAINING (E)-3,5-DIHYDROXY-7-[4¦-4"-FLUOROPHENYL-2'-CYCLOPRO PYL-QUINOLIN-3'-YL]-6-HEPTENOIC ACID</font> | |
| FI86373B (en) | Coating for a pharmaceutical tablet with delayed action and a method for the production of a tablet | |
| GB908282A (en) | Coated pharmaceutical granules and tablets thereof | |
| US5322698A (en) | Process for the preparation of a tablet or dragee composition containing a heat-, light- and moisture-sensitive active ingredient having monoclinic crystal structure | |
| US3128226A (en) | Composition for relieving pain | |
| US2298122A (en) | Digitalis capsule | |
| GB760403A (en) | Improvements in or relating to enteric coatings | |
| GB630439A (en) | Improvements in or relating to pharmaceutical preparations | |
| US3398225A (en) | Coated 2, 2-dichlorovinyl phosphate and polyvinyl chloride resin anthelmintic compositions | |
| KR20030081027A (en) | Coated solid preparation having hypnotic action | |
| US3197370A (en) | Pyrilamine tannate compositions | |
| US3326760A (en) | Choline salicylate polygalacturonate therapy | |
| US4900559A (en) | Stabilized enteric coated aspirin granules and process of preparation | |
| GB2061111A (en) | Long acting pharmaceutical composition | |
| EP0159735A1 (en) | Pharmaceutical composition containing tetracyclin or doxycyclin salts and a process of preparing such a composition | |
| GB764342A (en) | Improvements in or relating to coated water soluble tablets | |
| US2282290A (en) | Anthelmintic tablet |