GB832017A - Senna preparations - Google Patents
Senna preparationsInfo
- Publication number
- GB832017A GB832017A GB3089157A GB3089157A GB832017A GB 832017 A GB832017 A GB 832017A GB 3089157 A GB3089157 A GB 3089157A GB 3089157 A GB3089157 A GB 3089157A GB 832017 A GB832017 A GB 832017A
- Authority
- GB
- United Kingdom
- Prior art keywords
- product
- senna
- metal
- organic solvent
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 235000006693 Cassia laevigata Nutrition 0.000 title abstract 4
- 241000522641 Senna Species 0.000 title abstract 4
- 229940124513 senna glycoside Drugs 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 3
- 229910021645 metal ion Inorganic materials 0.000 abstract 3
- 239000003960 organic solvent Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 238000001556 precipitation Methods 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 241000792859 Enema Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 229940112822 chewing gum Drugs 0.000 abstract 1
- 235000015218 chewing gum Nutrition 0.000 abstract 1
- 235000019219 chocolate Nutrition 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000007920 enema Substances 0.000 abstract 1
- 229940079360 enema for constipation Drugs 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000007937 lozenge Substances 0.000 abstract 1
- -1 oxalic acid Chemical class 0.000 abstract 1
- 235000006408 oxalic acid Nutrition 0.000 abstract 1
- 235000010603 pastilles Nutrition 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
An extract of senna is prepared by extracting senna leaf or pod (with or without seed) with an aqueous organic solvent and adding to the separated liquid extract a metal salt and an anhydrous organic solvent to cause precipitation of a water-soluble product comprising the active principles of senna in intimate association with the metal ion of the salt. The product may be further treated to remove metal ions, e.g. by precipitation with an organic acid, e.g. oxalic acid, or by means of a strongly acid ion exchange resin. The product freed from metal ions may be further purified, e.g. by chromatography to give a stable crystalline product. The aqueous organic solvent may be water and ethanol, acetone or isopropanol (50 to 80%, preferably 70% v/w.) and may also contain an organic acid. The anhydrous solvent may be ethanol, acetone or isopropanol and the metal salt is preferably one of an alkaline earth metal, e.g. calcium. The product may be incorporated in conventional pharmaceutical forms, e.g. tablets, pills, capsules, cachets, chocolate, chewing gum, pastilles, lozenges, granules, suppositories, enemas, syrups, elixirs or injections, alone or with other therapeutic agents.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3089157A GB832017A (en) | 1957-10-02 | 1957-10-02 | Senna preparations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3089157A GB832017A (en) | 1957-10-02 | 1957-10-02 | Senna preparations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB832017A true GB832017A (en) | 1960-04-06 |
Family
ID=10314739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3089157A Expired GB832017A (en) | 1957-10-02 | 1957-10-02 | Senna preparations |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB832017A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1158211B (en) * | 1961-09-02 | 1963-11-28 | Ludwig Heumann & Co Chemisch P | Process for the production of dry powders with active ingredients from senna leaves or pods |
| US3519655A (en) * | 1963-05-24 | 1970-07-07 | Westminster Lab Ltd | Lithium rheinanthrone and lithium rheinanthrone complex salt |
| FR2519253A1 (en) * | 1982-01-05 | 1983-07-08 | Madaus & Co Dr | METHOD FOR ISOLATING SENE MEDICINAL LAXATIVE EFFECT COMPOUNDS, THESE COMPOUNDS AND THEIR THERAPEUTIC USES |
| DE4120991A1 (en) * | 1991-06-25 | 1993-01-07 | Madaus Ag | PROCESS FOR OBTAINING SENNOSIDES A, B AND A1 |
| CN1037684C (en) * | 1991-06-25 | 1998-03-11 | 马道斯有限公司 | Selected sennosides, processes for their preparation and pharmaceutical compositions containing them |
-
1957
- 1957-10-02 GB GB3089157A patent/GB832017A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1158211B (en) * | 1961-09-02 | 1963-11-28 | Ludwig Heumann & Co Chemisch P | Process for the production of dry powders with active ingredients from senna leaves or pods |
| US3519655A (en) * | 1963-05-24 | 1970-07-07 | Westminster Lab Ltd | Lithium rheinanthrone and lithium rheinanthrone complex salt |
| FR2519253A1 (en) * | 1982-01-05 | 1983-07-08 | Madaus & Co Dr | METHOD FOR ISOLATING SENE MEDICINAL LAXATIVE EFFECT COMPOUNDS, THESE COMPOUNDS AND THEIR THERAPEUTIC USES |
| DE4120991A1 (en) * | 1991-06-25 | 1993-01-07 | Madaus Ag | PROCESS FOR OBTAINING SENNOSIDES A, B AND A1 |
| CN1037684C (en) * | 1991-06-25 | 1998-03-11 | 马道斯有限公司 | Selected sennosides, processes for their preparation and pharmaceutical compositions containing them |
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