GB834984A - Optically active aryl-(2-pyridyl) aryl-substituted tertiary amines - Google Patents
Optically active aryl-(2-pyridyl) aryl-substituted tertiary aminesInfo
- Publication number
- GB834984A GB834984A GB21467/58A GB2146758A GB834984A GB 834984 A GB834984 A GB 834984A GB 21467/58 A GB21467/58 A GB 21467/58A GB 2146758 A GB2146758 A GB 2146758A GB 834984 A GB834984 A GB 834984A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- optically active
- aryl
- radical
- pyridyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises optically active forms of compounds of the general formula <FORM:0834984/IV (b)/1> wherein Py is a 2-pyridyl residue, R represents a phenyl or a halogenated phenyl radical, and R1 represents a dialkylamino group or a morpholino, piperidino, or pyrrolidino radical; and acid addition salts thereof, particularly phenyl succinates, maleates, gluconates 8-halogenotheophyllinates, and 8-halogenoxanthinates; and the preparation thereof by resolution of appropriate racemates by means of optically active substituted succinic acids, especially phenyl- or substituted phenyl-succinic acids or, in the cases where R is phenyl, by dehalohydrogenation of optically active compounds of the above general formula where R is a halogenated phenyl radical using palladium on carbon or Raney nickel as catalyst; and, if desired, conversion of the products into acid addition salts by customary methods. The d-isomers have antihistaminic activity and the l-isomers have local anaesthetic properties and are useful as anti-emetics.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US834984XA | 1958-03-04 | 1958-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB834984A true GB834984A (en) | 1960-05-18 |
Family
ID=22178735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB21467/58A Expired GB834984A (en) | 1958-03-04 | 1958-07-04 | Optically active aryl-(2-pyridyl) aryl-substituted tertiary amines |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE1268620B (en) |
| GB (1) | GB834984A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111499567A (en) * | 2020-04-26 | 2020-08-07 | 上海新华联制药有限公司 | Chlorpheniramine maleate, preparation method and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE538932A (en) * | 1954-06-15 |
-
1958
- 1958-07-04 GB GB21467/58A patent/GB834984A/en not_active Expired
- 1958-11-12 DE DEP1268A patent/DE1268620B/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111499567A (en) * | 2020-04-26 | 2020-08-07 | 上海新华联制药有限公司 | Chlorpheniramine maleate, preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1268620B (en) | 1968-05-22 |
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