GB834248A - Improvements in or relating to process of reducing 3-hydroxypyridine and derivatives thereof - Google Patents
Improvements in or relating to process of reducing 3-hydroxypyridine and derivatives thereofInfo
- Publication number
- GB834248A GB834248A GB1878056A GB1878056A GB834248A GB 834248 A GB834248 A GB 834248A GB 1878056 A GB1878056 A GB 1878056A GB 1878056 A GB1878056 A GB 1878056A GB 834248 A GB834248 A GB 834248A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxypiperidine
- substituted
- hydroxypyridinium
- substituent
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
3-Hydroxypiperidine, or an N-substituted-3-hydroxypiperidine, or acid additions salts thereof, the N-substituent being an alkyl group of not more than 8 carbon atoms or an aralkyl group in which the alkyl moiety is greater than methyl, are prepared by a process including the step of hydrogenating under elevated temperature and pressure and in the presence of a nickel catalyst (1) 3-hydroxypiperidine or an N-benzyl - 3 - hydroxypyridinium salt to produce the 3-hydroxypiperidine, or (2) an N-substituted 3-hydroxypyridinium salt in which the N-substituent is as described above, to produce said N - substituted - 3 - hydroxypiperidine. The 3-hydroxypiperidine compound is dissolved in a solvent such as water, methanol, ethanol dioxane or mixtures thereof and hydrogenated preferably at pressures of 200 to 4000 pounds per square inch and temperatures ranging from 80 DEG to 250 DEG C. or higher in the presence of a Raney nickel catalyst.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1878056A GB834248A (en) | 1956-06-18 | 1956-06-18 | Improvements in or relating to process of reducing 3-hydroxypyridine and derivatives thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1878056A GB834248A (en) | 1956-06-18 | 1956-06-18 | Improvements in or relating to process of reducing 3-hydroxypyridine and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB834248A true GB834248A (en) | 1960-05-04 |
Family
ID=10118293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1878056A Expired GB834248A (en) | 1956-06-18 | 1956-06-18 | Improvements in or relating to process of reducing 3-hydroxypyridine and derivatives thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB834248A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0116255A3 (en) * | 1982-12-10 | 1985-11-06 | Merrell Dow France Et Cie | Treatment of migraine with n-alkyl-piperidinyl benzoate derivatives |
| CN108017572A (en) * | 2017-12-27 | 2018-05-11 | 江苏尚莱特医药化工材料有限公司 | （S）The preparation method of -3- hydroxy piperidines |
| CN110878041A (en) * | 2019-11-13 | 2020-03-13 | 上海星酶生物科技有限公司 | Preparation method of (S) -1-tert-butyloxycarbonyl-3-hydroxypiperidine |
-
1956
- 1956-06-18 GB GB1878056A patent/GB834248A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0116255A3 (en) * | 1982-12-10 | 1985-11-06 | Merrell Dow France Et Cie | Treatment of migraine with n-alkyl-piperidinyl benzoate derivatives |
| CN108017572A (en) * | 2017-12-27 | 2018-05-11 | 江苏尚莱特医药化工材料有限公司 | （S）The preparation method of -3- hydroxy piperidines |
| CN108017572B (en) * | 2017-12-27 | 2023-10-17 | 江苏尚莱特医药化工材料有限公司 | Process for the preparation of (S) -3-hydroxypiperidines |
| CN110878041A (en) * | 2019-11-13 | 2020-03-13 | 上海星酶生物科技有限公司 | Preparation method of (S) -1-tert-butyloxycarbonyl-3-hydroxypiperidine |
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