GB828522A - Purine derivatives and a process for the preparation thereof - Google Patents
Purine derivatives and a process for the preparation thereofInfo
- Publication number
- GB828522A GB828522A GB33640/57A GB3364057A GB828522A GB 828522 A GB828522 A GB 828522A GB 33640/57 A GB33640/57 A GB 33640/57A GB 3364057 A GB3364057 A GB 3364057A GB 828522 A GB828522 A GB 828522A
- Authority
- GB
- United Kingdom
- Prior art keywords
- purine
- amino
- preparation
- ethyl
- purine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title 1
- MSEHBVKOXAMOFB-UHFFFAOYSA-N 2-ethyl-1h-indol-3-amine Chemical compound C1=CC=C2C(N)=C(CC)NC2=C1 MSEHBVKOXAMOFB-UHFFFAOYSA-N 0.000 abstract 2
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
- FAIXYKHYOGVFKA-UHFFFAOYSA-N Kinetin Natural products N=1C=NC=2N=CNC=2C=1N(C)C1=CC=CO1 FAIXYKHYOGVFKA-UHFFFAOYSA-N 0.000 abstract 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229910000039 hydrogen halide Inorganic materials 0.000 abstract 1
- 239000012433 hydrogen halide Substances 0.000 abstract 1
- QANMHLXAZMSUEX-UHFFFAOYSA-N kinetin Chemical compound N=1C=NC=2N=CNC=2C=1NCC1=CC=CO1 QANMHLXAZMSUEX-UHFFFAOYSA-N 0.000 abstract 1
- 229960001669 kinetin Drugs 0.000 abstract 1
- 229960001428 mercaptopurine Drugs 0.000 abstract 1
- 229940072033 potash Drugs 0.000 abstract 1
- 235000015320 potassium carbonate Nutrition 0.000 abstract 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises 6 - [211 - indolyl - (21) - ethyl - amino] - purine and 6 - [211 - (51 - hydroxy - indolyl - 21) - ethyl - amino] - purine and their preparation by heating a 6-alkyl-mercapto-purine or a 6-halogene-purine with the appropriate amino-ethyl-indole, in the latter instance in the presence of a hydrogen halide binding agent, e.g. an excess of the amino-ethylindole or potash. An example is given. The products are stated to be antagonists to 6-furfurylamino - purine. Specifications 813,777 and 828,521 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH828522X | 1956-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB828522A true GB828522A (en) | 1960-02-17 |
Family
ID=4540127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB33640/57A Expired GB828522A (en) | 1956-11-02 | 1957-10-29 | Purine derivatives and a process for the preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB828522A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997018212A1 (en) * | 1995-11-14 | 1997-05-22 | Pharmacia & Upjohn S.P.A. | Aryl and heteroaryl purine compounds |
-
1957
- 1957-10-29 GB GB33640/57A patent/GB828522A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997018212A1 (en) * | 1995-11-14 | 1997-05-22 | Pharmacia & Upjohn S.P.A. | Aryl and heteroaryl purine compounds |
| US5965563A (en) * | 1995-11-14 | 1999-10-12 | Pharmacia & Upjohn S.P.A. | Aryl and heteroaryl purine compounds |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB828522A (en) | Purine derivatives and a process for the preparation thereof | |
| AU209956B2 (en) | Improvements in or relating to systems for high-frequency heating of work-pieces | |
| AU203853B2 (en) | Improvements in or relating to process for preparing alkali metal starch phosphate | |
| CA505164A (en) | Amino-ether gas treating process | |
| AU1630856A (en) | Improvements in or relating to systems for high-frequency heating of work-pieces | |
| GB801669A (en) | Process to produce model-pictures to be used, for example, in teaching drawing and painting | |
| AU1171655A (en) | Improvements in or relating to process for preparing alkali metal starch phosphate | |
| AU200499B2 (en) | Improvements in or relating to process for the recovery of tyrosine | |
| AU2377553A (en) | Improvements in or relating to heat balanced hydroforming process | |
| AU209333B2 (en) | Improvements in or relating to process for preparing lysergic acid amides | |
| ES224536A1 (en) | A procedure for the manufacture of knives and other domestic items with handles (Machine-translation by Google Translate, not legally binding) | |
| AU213099B2 (en) | Improvements in or relating to process forthe manufacture of oil-gas | |
| GB836543A (en) | Treating petroleum residues | |
| CA530609A (en) | Copper-lined ferrous article | |
| AU1570756A (en) | Improvements in or relating tothe manufacture of composite metal articles | |
| AU167939B2 (en) | Improvements in or relating to methods of making cylindrical, more particularly stylus-shaped articles | |
| AU2400056A (en) | Improvements in or relating to methods of induction heating of workpieces | |
| CA528479A (en) | Process for the production of brown chrome containing dyestuffs | |
| AU208404B2 (en) | Improvements in or relating tothe production of heparin | |
| AU207340B2 (en) | Improvements in or relating tothe production of heparin | |
| ES240777A1 (en) | Procedure for obtaining intermediate coloring products (Machine-translation by Google Translate, not legally binding) | |
| AU215052B2 (en) | Improvements in the production of articles | |
| AU1514256A (en) | Improvements in or relating to process forthe manufacture of oil-gas | |
| AU217068B2 (en) | Improvements in or relating to chemical process | |
| CA518842A (en) | Process of preparing hexachlorobenzene |