GB826668A - Process for manufacturing basic carboxamides - Google Patents
Process for manufacturing basic carboxamidesInfo
- Publication number
- GB826668A GB826668A GB1848155A GB1848155A GB826668A GB 826668 A GB826668 A GB 826668A GB 1848155 A GB1848155 A GB 1848155A GB 1848155 A GB1848155 A GB 1848155A GB 826668 A GB826668 A GB 826668A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- hydrogen
- dimethylanilide
- carbon atoms
- hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003857 carboxamides Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 abstract 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 N - methylhexahydropicolyl Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003883 ointment base Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Carboxamides of the general formulae <FORM:0826668/IV (b)/1> <FORM:0826668/IV (b)/2> and their acid addition salts (R3 and R4 represent hydrogen atoms or alkyl groups, R5 represents an alkyl group containing from 1 to 5 carbon atoms, and of the symbols X, Y and Z two are hydrogen or alkyl (and may be different) and the other represents the group -CONR1R2 wherein R1 is aryl which may be substituted e.g. by alkyl or alkoxy groups of from 1 to 7 carbon atoms, and R2 is hydrogen) are prepared by forming by mixed anhydride synthesis a carboxamide of formulae <FORM:0826668/IV (b)/3> <FORM:0826668/IV (b)/4> reacting the carboxamide with an alkylating agent R5A (A is an acid residue) and then selectively hydrogenating the product. Detailed examples illustrate the preparation of N - methylhexahydropicolyl - 2,6 - dimethylanilide hydriodide, N - methylhexahydroisonicotinyl-2,6-dimethylanilide hydrochloride, Nmethylhexahydronicotinyl 2,6-dimethylanilide hydriodide, N - ethylhexahydroisonicotinyl2,6 - dimethylanilide hydrochloride and Nmethyltetrahydroquinaldinyl - 2,6 - dimethylanilide and its hydrochloride. Specification 770,129 is referred to.ALSO:Anaesthetic compositions comprise carboxamides of the formulae <FORM:0826668/VI/1> and their acid addition salts (R3 and R4 are hydrogen or alkyl groups, R5 is alkyl containing less than 6 carbon atoms, two or X, Y and Z are hydrogen or alkyl and the third is -CONR1R2, where R1 is aryl and R2 is hydrogen) together with a pharmaceutical carrier, e.g. an aqueous or non-aqueous solvent for injection, or an ointment base for topical application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1848155A GB826668A (en) | 1955-06-27 | 1955-06-27 | Process for manufacturing basic carboxamides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1848155A GB826668A (en) | 1955-06-27 | 1955-06-27 | Process for manufacturing basic carboxamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB826668A true GB826668A (en) | 1960-01-20 |
Family
ID=10113167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1848155A Expired GB826668A (en) | 1955-06-27 | 1955-06-27 | Process for manufacturing basic carboxamides |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB826668A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2355826A1 (en) * | 1976-06-22 | 1978-01-20 | Bofors Ab | PROCESS FOR THE PREPARATION OF 2,6-XYLYLIDE HYDROCHLORIDE FROM N-METHYL-PIPERIDINE-2-CARBOXYLIC ACID |
| US11406738B2 (en) | 2013-07-30 | 2022-08-09 | Teoxane | Composition comprising hyaluronic acid and mepivacaine |
-
1955
- 1955-06-27 GB GB1848155A patent/GB826668A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2355826A1 (en) * | 1976-06-22 | 1978-01-20 | Bofors Ab | PROCESS FOR THE PREPARATION OF 2,6-XYLYLIDE HYDROCHLORIDE FROM N-METHYL-PIPERIDINE-2-CARBOXYLIC ACID |
| US11406738B2 (en) | 2013-07-30 | 2022-08-09 | Teoxane | Composition comprising hyaluronic acid and mepivacaine |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB826668A (en) | Process for manufacturing basic carboxamides | |
| ES358689A1 (en) | Process for making 2-benzimidazolecarbamic acid alkyl esters | |
| GB959203A (en) | Indole derivatives and salts thereof | |
| GB1124441A (en) | Novel noralkaloids and process for preparing same | |
| US2930799A (en) | Bicyclic anhydride of meso-alpha, alpha'-dithioadipic acid and method of making the same | |
| GB948175A (en) | Process for the production of 2, 4-diamino-6-trichloromethyl-úË-triazines | |
| GB978550A (en) | Acylacetylaminobenzene compounds containing sulphonic acid groups and process for their manufacture | |
| GB930676A (en) | Process for the preparation of 20-alkylamino steroid derivatives and novel 20-alkylamino steroid derivatives prepared thereby | |
| ES297620A1 (en) | Procedure for obtaining derivatives of phenoxyactic acid (Machine-translation by Google Translate, not legally binding) | |
| GB673413A (en) | New local anaesthetics which are substituted benzoic esters and processes for making the same | |
| GB823338A (en) | Diquaternary salts of aminoalkyl piperidines | |
| GB665675A (en) | Process for the manufacture of derivatives of hydroxy acids | |
| GB771151A (en) | Method for the preparation of aminoacyl-anilides | |
| GB923895A (en) | New carboxylic acid amides and process for their manufacture | |
| ES314090A1 (en) | Procedure for the preparation of amidas of carboxilic acids. (Machine-translation by Google Translate, not legally binding) | |
| US2460224A (en) | Biotin intermediate | |
| GB784892A (en) | Piperidine derivatives and process for their manufacture | |
| GB904680A (en) | Process for the production of o-quinones | |
| ES229816A1 (en) | Procedure for the preparation of some derivatives of dialkilditiofosforic acids with a double amid function in the molecule (Machine-translation by Google Translate, not legally binding) | |
| GB845499A (en) | Improvements in and relating to aminoalkyl-and aminoaralkyl-cycloplutadecenyl iron compounds | |
| GB837008A (en) | Basically substituted butyric acid amides and a process for their manufacture | |
| GB899385A (en) | Improvements in or relating to new hydrazine derivatives and process for their preparation | |
| GB717213A (en) | Method of preparing anaesthetics | |
| GB866432A (en) | New carboxylic acid amides substituted at the nitrogen atom and ª--carbon atom | |
| GB917940A (en) | ª--spiro-glutarimides |