GB801856A - The production of lyophilised preparations - Google Patents
The production of lyophilised preparationsInfo
- Publication number
- GB801856A GB801856A GB6062/56A GB606256A GB801856A GB 801856 A GB801856 A GB 801856A GB 6062/56 A GB6062/56 A GB 6062/56A GB 606256 A GB606256 A GB 606256A GB 801856 A GB801856 A GB 801856A
- Authority
- GB
- United Kingdom
- Prior art keywords
- solution
- freeze
- flask
- drying
- layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000243 solution Substances 0.000 abstract 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- 229930006000 Sucrose Natural products 0.000 abstract 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 238000004108 freeze drying Methods 0.000 abstract 2
- 238000007710 freezing Methods 0.000 abstract 2
- 230000008014 freezing Effects 0.000 abstract 2
- 229960004793 sucrose Drugs 0.000 abstract 2
- 241000167854 Bourreria succulenta Species 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- USKZELCAOLQCES-UHFFFAOYSA-N N-[8-hydroxy-5-[(2-sulfamoylphenyl)diazenyl]naphthalen-2-yl]acetamide Chemical compound C(C)(=O)NC1=CC=C2C(=CC=C(C2=C1)O)N=NC1=C(C=CC=C1)S(N)(=O)=O USKZELCAOLQCES-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 235000019693 cherries Nutrition 0.000 abstract 1
- 239000000975 dye Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
A process for producing stable chemical preparations including at least two components which are incompatible in common solution consists in successively freezing separate solutions comprising said components within a common vessel to form a stratified frozen mass and thereafter freeze-drying said frozen mass. In one example of the process, a flask of 5 c.c. capacity was filled with 3 c.c. of an aqueous solution of 20 mg. of glycine and 2 mg. of gelatin per c.c. and placed upon a metal plate cooled to about -85 DEG C. by a mixture of carbon dioxide and acetone so as to freeze the solution. Thereupon, 1 c.c. of a similar solution, together with 10 mg. of a sodium salt of 7-acetamido-4-(sulphamyl-phenylazo) - 1 - naphthol - 3,6 - disulphonic acid, a strong red dyestuff is added to the flask. Upon freezing of the added solution, the whole is freeze-dried at an initial temperature of -40 DEG C. and an absolute pressure of 0.01 mm. of Hg, the temperature being gradually raised to 40 DEG C. The resulting product has a lower white layer and an upper cherry red layer. In another example, the above process was repeated with 2 c.c. of an aqueous solution of 45 mg. of sodium bicarbonate and 40 mg. of cane sugar per c.c. as a lower layer, and 2 c.c. of a solution of 25 mg. of citric acid and 40 mg. of cane sugar. Following freeze-drying there was obtained a finely-structured mass consisting of two distinct layers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE801856X | 1955-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB801856A true GB801856A (en) | 1958-09-24 |
Family
ID=6717089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6062/56A Expired GB801856A (en) | 1955-02-25 | 1956-02-27 | The production of lyophilised preparations |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB801856A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4754597A (en) * | 1981-12-11 | 1988-07-05 | John Wyeth & Brother Ltd. | Solid shaped articles |
-
1956
- 1956-02-27 GB GB6062/56A patent/GB801856A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4754597A (en) * | 1981-12-11 | 1988-07-05 | John Wyeth & Brother Ltd. | Solid shaped articles |
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