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GB808701A - Production of tetracyclinonitrile - Google Patents

Production of tetracyclinonitrile

Info

Publication number
GB808701A
GB808701A GB3038/56A GB303856A GB808701A GB 808701 A GB808701 A GB 808701A GB 3038/56 A GB3038/56 A GB 3038/56A GB 303856 A GB303856 A GB 303856A GB 808701 A GB808701 A GB 808701A
Authority
GB
United Kingdom
Prior art keywords
tetracyclinonitrile
catalyst
hydrogenation
production
tetracyclino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3038/56A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB808701A publication Critical patent/GB808701A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Tetracyclinonitrile is prepared by reducing chlor- or brom-tetracyclinonitrile by hydrogenation in the presence of a hydrogenation catalyst, preferably a palladium charcoal catalyst and an inert organic solvent such as 2-ethoxyethanol. Preferably a tertiary amine base such as triethylamine or pyridine should be present. When the take-up of hydrogen ceases, the catalyst is filtered off and ethanolic hydrochloric acid is added until the pH drops to 3.0 to 3.5, the tetracyclino-nitrile crystals which separate being removed. Specification 808,702 is referred to. Reference has been directed by the Comptroller to Specification 766,512.
GB3038/56A 1955-02-14 1956-01-31 Production of tetracyclinonitrile Expired GB808701A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US808701XA 1955-02-14 1955-02-14

Publications (1)

Publication Number Publication Date
GB808701A true GB808701A (en) 1959-02-11

Family

ID=22160170

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3038/56A Expired GB808701A (en) 1955-02-14 1956-01-31 Production of tetracyclinonitrile

Country Status (1)

Country Link
GB (1) GB808701A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3030377A (en) * 1959-08-27 1962-04-17 Hoechst Ag Process for the manufacture of nitriles of tetracyclines
US3159631A (en) * 1960-08-30 1964-12-01 Smith Kline French Lab Nu-aminomethyltetracycline derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3030377A (en) * 1959-08-27 1962-04-17 Hoechst Ag Process for the manufacture of nitriles of tetracyclines
US3159631A (en) * 1960-08-30 1964-12-01 Smith Kline French Lab Nu-aminomethyltetracycline derivatives

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